8364:dctn2
gene id: 8364:dctn2
uniprot id: A0A8J0S7J2
uniprot id: A0A8J0SCH2
uniprot id: A0A8J0T0Q3
uniprot id: Q5FW42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dynactin subunit 2 family.
messages: Membrane
messages: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes (By similarity).
messages: Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3.
messages: centrosome
messages: cytoskeleton

8364:tgm3l.4
gene id: 8364:tgm3l.4
uniprot id: F6YIZ4
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

8364:MGC147172
gene id: 8364:MGC147172
uniprot id: Q0P4K7
names: Similarity
messages: Belongs to the cornifelin family.

8364:olfm3
gene id: 8364:olfm3
uniprot id: A0A803JYW5
uniprot id: F6Y788
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Synapse

8364:LOC116406834
gene id: 8364:LOC116406834
uniprot id: A0A6I8QX50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:rpain
gene id: 8364:rpain
uniprot id: B1H156
names: Subcellular Location Annotation
messages: Nucleus

8364:crx
gene id: 8364:crx
uniprot id: B1H3B9
uniprot id: F7B883
uniprot id: Q28EM7
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription factor involved in anterior and eye development. Promotes the differentiation of both rod and cone photoreceptors cells in the retina. Together with other retinal homeobox proteins, acts as an effector of a cellular clock which, depending on cell cycle progression, establishes the generation of distinct retinal neuronal cell types. Acts synergistically with nrl to activate the rhodopsin promoter. Promotes the formation of anterior regions and represses the formation of posterior structures during development (By similarity).

8364:parg
gene id: 8364:parg
uniprot id: A0A6I8PX69
uniprot id: B1H3J2
names: Similarity
messages: Belongs to the poly(ADP-ribose) glycohydrolase family.

8364:LOC101732669
gene id: 8364:LOC101732669
uniprot id: A0A8J1IXA7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8364:mcidas
gene id: 8364:mcidas
uniprot id: A0A8J0QUM7
uniprot id: A0A8J0QYW9
uniprot id: F7BHS0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the geminin family.
messages: Component of the EDM complex, at least composed of e2f4, e2f5, mcidas and tfdp1.
messages: Nucleus
messages: The TIRT domain mediates interaction with e2f4 and tfdp1.
messages: Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing e2f4 and e2f5 that binds and activate genes required for centriole biogenesis. Activates genes required for centriole assembly (plk4, cep152) and genes specifically required for motile cilia formation (foxj1). Also promotes the deuterosome pathway of centriole biogenesis by activating expression of deup1, but not its paralog cep63.

8364:impa1
gene id: 8364:impa1
uniprot id: A0A8J0SR63
uniprot id: Q28FW1
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

8364:slc26a10
gene id: 8364:slc26a10
uniprot id: A0A8J1J7P4
uniprot id: A0A8J1J8P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

8364:mmp19
gene id: 8364:mmp19
uniprot id: F6TVV1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

8364:LOC116408387
gene id: 8364:LOC116408387
uniprot id: A0A8J1J1Y4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:prkcq
gene id: 8364:prkcq
uniprot id: A0A8J0S8T2
uniprot id: A4IGL9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

8364:LOC100497766
gene id: 8364:LOC100497766
uniprot id: F6U3S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8364:ncan
gene id: 8364:ncan
uniprot id: A0A6I8Q003
uniprot id: F6YUS7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:setdb1
gene id: 8364:setdb1
uniprot id: A0A8J0QGF2
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

8364:dpp4
gene id: 8364:dpp4
uniprot id: A0A8J0SY12
uniprot id: A1L0Z8
uniprot id: Q28CN9
names: Subcellular Location Annotation
messages: Cell membrane
messages: invadopodium membrane
messages: lamellipodium membrane

8364:btf3
gene id: 8364:btf3
uniprot id: A0A8J0PIV1
uniprot id: F6ZEI6
names: Similarity
messages: Belongs to the NAC-beta family.

8364:apoc1
gene id: 8364:apoc1
uniprot id: A0A8J0QYU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C1 family.
messages: Secreted

8364:LOC100489361
gene id: 8364:LOC100489361
uniprot id: A0A8J0T657
names: Similarity
messages: Belongs to the peptidase M14 family.

8364:isca2
gene id: 8364:isca2
uniprot id: A0A8J0QUS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

8364:cnnm4
gene id: 8364:cnnm4
uniprot id: A0A8J0SRV9
uniprot id: A0JPA0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Cell membrane
messages: Membrane
messages: Metal transporter.
messages: Probable metal transporter.
messages: Shares weak sequence similarity with the cyclin family, hence its name. However, it has no cyclin-like function in vivo.

8364:grik1
gene id: 8364:grik1
uniprot id: A0A6I8S113
uniprot id: A0A6I8T0W3
uniprot id: A0A8J0R164
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8364:LOC105945159
gene id: 8364:LOC105945159
uniprot id: A0A8J0SCU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:elovl7
gene id: 8364:elovl7
uniprot id: Q6GLC3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL7 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

8364:fmnl2
gene id: 8364:fmnl2
uniprot id: A0A6I8QPV0
uniprot id: A0A6I8QVV0
uniprot id: A0A6I8S2E4
uniprot id: A0A8J0QPG2
uniprot id: A0A8J0SVY3
uniprot id: A0A8J0SXS7
uniprot id: A0A8J0SYF1
names: Similarity
messages: Belongs to the formin homology family.

8364:hoxc10
gene id: 8364:hoxc10
uniprot id: F7BEF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

8364:hba1
gene id: 8364:hba1
uniprot id: P07428
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.
messages: Red blood cells.

8364:ar
gene id: 8364:ar
uniprot id: A0A6I8RK73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

8364:ebf2
gene id: 8364:ebf2
uniprot id: A0A6I8R0P0
uniprot id: A0A8J0SGV8
uniprot id: G1K3E3
uniprot id: Q6P4K7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: May play a pivotal role in the transcriptional cascade that specifies primary neurons in embryos. Stabilizes the higher neural potential of selected progenitor cells that express neurog2/X-ngnr-1 by maintaining Delta-Notch signaling. Thus ensures the transition between neural competence and irreversible commitment to a neural fate. Also promotes neuronal differentiation by activating neurod1 expression, directly or indirectly (By similarity).
messages: Nucleus

8364:rhbdd2
gene id: 8364:rhbdd2
uniprot id: Q6DEX4
names: Subcellular Location Annotation
messages: Membrane

8364:mettl1
gene id: 8364:mettl1
uniprot id: Q28H76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalytic component of METTL1-WDR4 methyltransferase complex that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop. M7G46 interacts with C13-G22 in the D-loop to stabilize tRNA tertiary structure and protect tRNAs from decay. Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs. Internal N(7)-methylguanine methylation of mRNAs in response to stress promotes their relocalization to stress granules, thereby suppressing their translation. Also methylates a specific subset of miRNAs.
messages: Catalytic component of the METTL1-WDR4 complex, composed of mettl1 and wdr4.
messages: Nucleus

8364:lrwd1
gene id: 8364:lrwd1
uniprot id: B0JZ65
uniprot id: F6V4R8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LRWD1 family.
messages: Component of the ORC complex.
messages: Nucleus
messages: Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability (By similarity).
messages: The entire WD repeat region is required for the interaction with ORC complex components, as well as for association with chromatin and for binding to histone methylation marks.
messages: centromere
messages: centrosome
messages: kinetochore
messages: telomere

8364:LOC100496024
gene id: 8364:LOC100496024
uniprot id: A0A8J1IQ11
names: Similarity
messages: Belongs to the MHC class I family.

8364:LOC116411533
gene id: 8364:LOC116411533
uniprot id: A0A8J1JPM0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:atp13a5l.1
gene id: 8364:atp13a5l.1
uniprot id: A0A6I8RJM3
uniprot id: A0A8J0SP88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

8364:mab21l1
gene id: 8364:mab21l1
uniprot id: B1H177
uniprot id: Q0V9X7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mab-21 family.
messages: Monomer. Homodecamer; composed of 2 back to back homopentamers. The protein may exist as monomer in solution and oiligomerizes upon ligand binding.
messages: Nucleus
messages: Putative nucleotidyltransferase required for several aspects of embryonic development including normal development of the eye (By similarity). It is unclear whether it displays nucleotidyltransferase activity in vivo. Binds single-stranded RNA (ssRNA) (By similarity).

8364:tmtc3
gene id: 8364:tmtc3
uniprot id: A0A8J1JDQ1
uniprot id: F7CL48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

8364:LOC105945397
gene id: 8364:LOC105945397
uniprot id: A0A8J1JUV8
names: Subcellular Location Annotation
messages: Membrane

8364:sin3b
gene id: 8364:sin3b
uniprot id: A0A8J0SQC0
uniprot id: Q0VA09
names: Subcellular Location Annotation
messages: Nucleus

8364:ywhae
gene id: 8364:ywhae
uniprot id: A0A8J0SFA1
uniprot id: Q66IF5
names: Function
names: Similarity
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
messages: Belongs to the 14-3-3 family.

8364:grid1
gene id: 8364:grid1
uniprot id: A0A8J1JUA7
uniprot id: A4IIZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8364:rdh13
gene id: 8364:rdh13
uniprot id: A0A8J0T375
uniprot id: Q640T9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8364:smc6
gene id: 8364:smc6
uniprot id: A0A6I8SJJ1
names: Subcellular Location Annotation
messages: Chromosome

8364:hoxa11
gene id: 8364:hoxa11
uniprot id: A0A8J0QIT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

8364:map2k5
gene id: 8364:map2k5
uniprot id: Q28G43
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:casp9
gene id: 8364:casp9
uniprot id: A0A803JYQ8
uniprot id: B0JZV1
names: Similarity
messages: Belongs to the peptidase C14A family.

8364:add3
gene id: 8364:add3
uniprot id: A0A6I8Q9X6
uniprot id: A0A6I8RRT6
uniprot id: Q28CK2
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

8364:LOC100491800
gene id: 8364:LOC100491800
uniprot id: A0A8J1JAS7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:kdm4b
gene id: 8364:kdm4b
uniprot id: A0A6I8QA80
uniprot id: A0A8J0SG29
uniprot id: A0A8J0SYR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM3 histone demethylase family.
messages: Nucleus

8364:cdx4
gene id: 8364:cdx4
uniprot id: Q90X88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

8364:psd
gene id: 8364:psd
uniprot id: A0A8J1JWD1
uniprot id: A0A8J1JYV0
names: Subcellular Location Annotation
messages: ruffle membrane

8364:LOC105947301
gene id: 8364:LOC105947301
uniprot id: A0A6I8SB07
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:fam221a
gene id: 8364:fam221a
uniprot id: A0A8J0SGA7
uniprot id: A0A8J0SQX3
uniprot id: B0BMN2
uniprot id: Q28J59
names: Similarity
messages: Belongs to the FAM221 family.

8364:ube2g1
gene id: 8364:ube2g1
uniprot id: Q6P888
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8364:tbx2
gene id: 8364:tbx2
uniprot id: Q3SA48
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds DNA as a monomer.
messages: Expressed ventrally in early gastrulae (stage 10.5) and is expressed most strongly in the outer layer of ectodermal cells. At the late gastrula stage (stage 12), expression appears to be up-regulated consistently in a small group of cells clustered around the ventral edge of the closing blastopore. At the early neurula stage (stage 13), four regions of ectodermal expression are clearly detected. At stage 19 (late neurula), expression persists in the cement gland, the ventral epidermis, the proctodeal region, the lens placodes, and in a broad placodal area caudal to the eye anlagen. In addition, expression also detected in the dorsal root ganglia of the future spinal cord. At stage 21/22, expression seen in a wishbone-shaped group of cells situated dorsal and caudal to each developing optic vesicle corresponding to the cranial (profundal and trigeminal) ganglia. Expression persists in these cells through tail bud and into early tadpole stages. From stage 21/22 onward, the bilateral expression in the ectodermal placodes becomes restricted primarily to the otic placode and the developing otic vesicles. At stage 24, also observed in the precursors of the hypaxial muscles and the pronephric duct in the trunk, in the developing branchial arches and in the primordium of the heart. In stage 29 embryos, expression detected in the frontonasal process and continues to be expressed in the same regions of the embryo at stage 33, although its expression becomes clearly regionalized in the looping heart. A higher level of expression seen in the ventricle as compared with the atrium.
messages: Nucleus
messages: Transcription factor which acts as a transcriptional repressor (By similarity). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (By similarity).

8364:sia2
gene id: 8364:sia2
uniprot id: A0A1B4ZDM5
names: Subcellular Location Annotation
messages: Nucleus

8364:capn6
gene id: 8364:capn6
uniprot id: A0A6I8S643
names: Similarity
messages: Belongs to the peptidase C2 family.

8364:gpx7
gene id: 8364:gpx7
uniprot id: Q0IIT7
names: Similarity
messages: Belongs to the glutathione peroxidase family.

8364:MGC75753
gene id: 8364:MGC75753
uniprot id: Q6PBE6
names: Similarity
messages: Belongs to the BTG family.

8364:alg11
gene id: 8364:alg11
uniprot id: Q6P312
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Membrane

8364:pfkfb4
gene id: 8364:pfkfb4
uniprot id: A0A6I8RMH3
uniprot id: A0A6I8SQI0
uniprot id: Q6NVM7
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

8364:LOC100492860
gene id: 8364:LOC100492860
uniprot id: A0A8J0QYA8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:erbb2
gene id: 8364:erbb2
uniprot id: A0A8J0QWV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

8364:ppa1
gene id: 8364:ppa1
uniprot id: A0A8J0PJ34
uniprot id: Q28H25
names: Similarity
messages: Belongs to the PPase family.

8364:tfb2m
gene id: 8364:tfb2m
uniprot id: A0A803J4T1
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:nck2
gene id: 8364:nck2
uniprot id: Q66K98
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

8364:dph5
gene id: 8364:dph5
uniprot id: Q6DEZ3
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

8364:adamts17
gene id: 8364:adamts17
uniprot id: A0A6I8R858
uniprot id: A0A8J0QQU0
uniprot id: A0A8J0QXF4
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:ppp1r3c.1
gene id: 8364:ppp1r3c.1
uniprot id: A9JTM1
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.
messages: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase.

8364:tmed10
gene id: 8364:tmed10
uniprot id: Q28FV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:mtpn
gene id: 8364:mtpn
uniprot id: Q6P1S6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myotrophin family.
messages: Cytoplasm
messages: Nucleus
messages: Regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex (By similarity).
messages: perinuclear region

8364:MGC108322
gene id: 8364:MGC108322
uniprot id: Q569D6
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:smad7
gene id: 8364:smad7
uniprot id: A0A8J0QYV9
uniprot id: F6X8Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

8364:syncrip
gene id: 8364:syncrip
uniprot id: A0A6I8QJW0
uniprot id: A0A8J0QJ86
uniprot id: A0A8J0R1L5
uniprot id: A0A8J0SER8
uniprot id: A0A8J0SLR8
uniprot id: A0A8J0SPD7
uniprot id: A0A8J0SPE2
uniprot id: A0A8J0SPF7
names: Subcellular Location Annotation
messages: Cytoplasm

8364:LOC100498016
gene id: 8364:LOC100498016
uniprot id: A0A8J1IQV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

8364:asxl1
gene id: 8364:asxl1
uniprot id: A0A8J1IX76
uniprot id: A0A8J1IXD3
names: Subcellular Location Annotation
messages: Nucleus

8364:bchel
gene id: 8364:bchel
uniprot id: A0A6I8PZR8
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

8364:iapp
gene id: 8364:iapp
uniprot id: A0A803JC56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcitonin family.
messages: Secreted

8364:tuba1b
gene id: 8364:tuba1b
uniprot id: B0BMH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

8364:elf5
gene id: 8364:elf5
uniprot id: F6RHY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8364:hba2
gene id: 8364:hba2
uniprot id: Q38IW0
names: Similarity
messages: Belongs to the globin family.

8364:fas
gene id: 8364:fas
uniprot id: A5JPX1
uniprot id: B7ZU83
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

8364:fxyd3
gene id: 8364:fxyd3
uniprot id: Q28CV9
names: Similarity
messages: Belongs to the FXYD family.

8364:slc35a1
gene id: 8364:slc35a1
uniprot id: A0A803KI15
uniprot id: F7AZM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8364:dclre1b
gene id: 8364:dclre1b
uniprot id: F7D944
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

8364:prps2
gene id: 8364:prps2
uniprot id: Q5XGI0
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activated by magnesium and inorganic phosphate. Competitively or non-competitively inhibited by ADP, 2,3-bisphosphoglyceride or GDP (By similarity).
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers (By similarity).

8364:LOC100492634
gene id: 8364:LOC100492634
uniprot id: A0A8J0T351
names: Similarity
messages: Belongs to the peptidase C1 family.

8364:dclre1a
gene id: 8364:dclre1a
uniprot id: A0A803J7M3
uniprot id: A0A8J0R840
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

8364:LOC105948131
gene id: 8364:LOC105948131
uniprot id: A0A8J0SVE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:admp
gene id: 8364:admp
uniprot id: F6SJC2
names: Similarity
messages: Belongs to the TGF-beta family.

8364:sptlc2
gene id: 8364:sptlc2
uniprot id: A0A6I8RJE0
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

8364:LOC100491890
gene id: 8364:LOC100491890
uniprot id: A0A803J568
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:LOC105946827
gene id: 8364:LOC105946827
uniprot id: A0A803JW21
names: Subcellular Location Annotation
messages: Nucleus

8364:marchf11
gene id: 8364:marchf11
uniprot id: A0A803J9U4
names: Subcellular Location Annotation
messages: Membrane

8364:psmc2
gene id: 8364:psmc2
uniprot id: Q6P7K3
names: Similarity
messages: Belongs to the AAA ATPase family.

8364:frem3
gene id: 8364:frem3
uniprot id: A0A6I8SNZ5
names: Similarity
messages: Belongs to the FRAS1 family.

8364:cdkn2aipnl
gene id: 8364:cdkn2aipnl
uniprot id: A9JSA0
uniprot id: F6UP40
names: Similarity
messages: Belongs to the CARF family.

8364:sumo3
gene id: 8364:sumo3
uniprot id: Q6DK72
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Cleavage of precursor form by a sentrin-specific protease is necessary for function.
messages: Cytoplasm
messages: Interacts with sae2 and ube2i. Covalently attached to a number of proteins (By similarity).
messages: PML body
messages: Polymeric chains can be formed through Lys-11 cross-linking.
messages: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i (By similarity).

8364:rhbg
gene id: 8364:rhbg
uniprot id: Q0IIV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Cytoplasmic vesicle membrane
messages: Functions as a specific ammonium transporter.

8364:ppp2ca
gene id: 8364:ppp2ca
uniprot id: Q6P365
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

8364:rpl13a
gene id: 8364:rpl13a
uniprot id: Q28HK3
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

8364:atg4d
gene id: 8364:atg4d
uniprot id: F7CGG3
uniprot id: Q28BL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

8364:rnf144a
gene id: 8364:rnf144a
uniprot id: A4IIY1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBR family. RNF144 subfamily.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes ube2l3 and ube2l6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: Lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family.
messages: Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain.
messages: Membrane

8364:tmem181
gene id: 8364:tmem181
uniprot id: A0A803JXL5
uniprot id: A4IIU4
uniprot id: Q28C49
names: Subcellular Location Annotation
messages: Membrane

8364:samd8
gene id: 8364:samd8
uniprot id: A0A6I8RF67
uniprot id: Q28CJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

8364:haghl
gene id: 8364:haghl
uniprot id: B0BMS0
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

8364:gorab
gene id: 8364:gorab
uniprot id: A0A6I8Q8D0
uniprot id: A0A8J0QYL7
names: Similarity
messages: Belongs to the GORAB family.

8364:p2ry13
gene id: 8364:p2ry13
uniprot id: Q5FWR3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:st3gal5
gene id: 8364:st3gal5
uniprot id: D2U4U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8364:wnt6
gene id: 8364:wnt6
uniprot id: A0A803K592
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8364:dgkk
gene id: 8364:dgkk
uniprot id: A0A6I8QSL2
uniprot id: A0A6I8S2Q6
uniprot id: A0A8J0R5N0
uniprot id: A0A8J0R6N0
uniprot id: A0A8J1INJ7
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

8364:tnfrsf1a
gene id: 8364:tnfrsf1a
uniprot id: B0BLZ4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:s1pr2
gene id: 8364:s1pr2
uniprot id: A0A803J917
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC116411995
gene id: 8364:LOC116411995
uniprot id: A0A8J1JUF2
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC101733686
gene id: 8364:LOC101733686
uniprot id: A0A8J0R1Z5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC100485793
gene id: 8364:LOC100485793
uniprot id: A0A8J1J2N8
names: Subcellular Location Annotation
messages: Membrane

8364:ramac
gene id: 8364:ramac
uniprot id: A8WGU7
uniprot id: Q28HC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAM family.
messages: Nucleus
messages: Regulatory subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Promotes the recruitment of the methyl donor, S-adenosyl-L-methionine, to RNMT. Regulates RNMT expression by a post-transcriptional stabilizing mechanism. Binds RNA.

8364:LOC100497309
gene id: 8364:LOC100497309
uniprot id: A0A8J0STY8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:atad3a
gene id: 8364:atad3a
uniprot id: Q6NVR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important role in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis (By similarity).
messages: Mitochondrion inner membrane
messages: mitochondrion nucleoid

8364:nxph4
gene id: 8364:nxph4
uniprot id: A0A6I8QUK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

8364:vstm5
gene id: 8364:vstm5
uniprot id: A0A7D9NK89
uniprot id: A0A8J0QW19
names: Subcellular Location Annotation
messages: Membrane

8364:antxrl
gene id: 8364:antxrl
uniprot id: A0A6I8R0Y5
uniprot id: A0A6I8SNY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

8364:LOC116406841
gene id: 8364:LOC116406841
uniprot id: A0A8J1ISE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100489081
gene id: 8364:LOC100489081
uniprot id: A0A8J1JC74
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

8364:baz2b
gene id: 8364:baz2b
uniprot id: A0A6I8SEY5
uniprot id: A0A8J0QN67
uniprot id: A0A8J0SP59
uniprot id: A0A8J0SP64
uniprot id: A0A8J0SP70
uniprot id: A0A8J0SW73
uniprot id: A0A8J0SW78
uniprot id: A0A8J0SW84
uniprot id: A0A8J0SW90
uniprot id: A0A8J0SY22
uniprot id: A0A8J0SY26
uniprot id: A0A8J0SY33
uniprot id: A0A8J0SYP4
uniprot id: A0A8J0SYP9
uniprot id: A0A8J0SYQ4
uniprot id: A0A8J0SZC0
uniprot id: A0A8J0SZD1
names: Similarity
messages: Belongs to the WAL family.

8364:zdhhc3
gene id: 8364:zdhhc3
uniprot id: A0A803J8Q3
uniprot id: Q5M8I6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8364:LOC101733166
gene id: 8364:LOC101733166
uniprot id: A0A8J1IWL3
names: Subcellular Location Annotation
messages: Nucleus

8364:fam83b
gene id: 8364:fam83b
uniprot id: F6RCU0
names: Similarity
messages: Belongs to the FAM83 family.

8364:mrrf
gene id: 8364:mrrf
uniprot id: Q0V9F8
names: Function
names: Similarity
messages: Belongs to the RRF family.
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

8364:hsd17b10
gene id: 8364:hsd17b10
uniprot id: Q28CR9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8364:mfap5
gene id: 8364:mfap5
uniprot id: A0A803K6Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: extracellular matrix

8364:LOC116409641
gene id: 8364:LOC116409641
uniprot id: A0A8J1J8P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100135185
gene id: 8364:LOC100135185
uniprot id: A9ULC9
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

8364:slc38a9
gene id: 8364:slc38a9
uniprot id: Q5M7S0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated component of the Ragulator complex. Associated component of the Rag GTPases heterodimers.
messages: Belongs to the amino acid/polyamine transporter 2 family. SLC38A9 subfamily.
messages: Glycosylated.
messages: Late endosome membrane
messages: Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids. Acts as an arginine sensor. Following activation by arginine binding, mediates transport of L-glutamine, leucine and tyrosine with high efficiency, and is required for the efficient utilization of these amino acids after lysosomal protein degradation. However, the transport mechanism is not well defined and the role of sodium is not clear. Guanine exchange factor (GEF) that, upon arginine binding, stimulates GDP release from RRAGA and therefore activates the Rag GTPase heterodimer and the mTORC1 pathway in response to nutrient sufficiency.
messages: Lysosome membrane
messages: The cytosolic N-terminus part of the protein mediates interaction with the Ragulator complex. The cytosolic N-terminus part of the protein mediates interaction with the Rag GTPase heterodimer in a RRAGA GDP-loaded state dependent and upon arginine binding, leading to the GDP release and SLC38A9 dissociation from the activated Rag GTPase heterodimer (By similarity). The cytosolic N-terminus part of the protein exists at least in two distinct conformations; The first is when the N-terminus is bound snugly in the arginine binding site (in the absence of arginine, low luminal arginine state) and the second is where the N-terminus is released and the substrate-binding site is occupied by arginine (in the presence of arginine, high luminal arginine state) (By similarity).
messages: the CARC and CRAC motifs mediate binding to cholesterol.

8364:cd81
gene id: 8364:cd81
uniprot id: Q6P351
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8364:rgs5
gene id: 8364:rgs5
uniprot id: A0JM97
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.

8364:gmppa
gene id: 8364:gmppa
uniprot id: A0A5S6N5I2
uniprot id: Q0VFM6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: GMPPA is a close homolog of GMPPB, that has been shown to catalyze the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids. It has been hypothesized that GMPPA might serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose. Alignment of GMPPAs and GMPPBs from various species shows that GMPPAs are characterized by a 2 amino acid-insertion (residues 11-12) in a highly conserved motif that borders the catalytic pocket and binds the nucleotide substrate in homologous enzymes. This insertion might inactivate the ancestral catalytic site, converting it to an allosteric site.
messages: May serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose.

8364:rbm15b
gene id: 8364:rbm15b
uniprot id: F7C1M9
names: Similarity
messages: Belongs to the RRM Spen family.

8364:LOC116406788
gene id: 8364:LOC116406788
uniprot id: A0A8J1ISU2
names: Subcellular Location Annotation
messages: Membrane

8364:hibadh
gene id: 8364:hibadh
uniprot id: Q5BKJ0
names: Similarity
messages: Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.

8364:haus3
gene id: 8364:haus3
uniprot id: A0A803K9B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS3 family.
messages: spindle

8364:LOC108646267
gene id: 8364:LOC108646267
uniprot id: A0A8J0SZQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:cpsf4l
gene id: 8364:cpsf4l
uniprot id: Q28DB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex.
messages: Nucleus

8364:krt8.1
gene id: 8364:krt8.1
uniprot id: Q6NVR6
names: Similarity
messages: Belongs to the intermediate filament family.

8364:st8sia2
gene id: 8364:st8sia2
uniprot id: Q0V9R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8364:atp8a2
gene id: 8364:atp8a2
uniprot id: A0A6I8RVK3
uniprot id: A0A8J0SH27
uniprot id: A0A8J1J5F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

8364:chac1
gene id: 8364:chac1
uniprot id: A0A5S6P2T9
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

8364:cdk14
gene id: 8364:cdk14
uniprot id: A0A6I8RNF5
uniprot id: A0A8J0SFF4
uniprot id: A0A8J0SQ59
uniprot id: A4IIW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Cell membrane
messages: Interacts with ccny; ccny mediates its recruitment to the plasma membrane and promotes phosphorylation of lrp6.
messages: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of lrp6, leading to the activation of the Wnt signaling pathway (By similarity).

8364:rpl18
gene id: 8364:rpl18
uniprot id: Q63ZF9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

8364:LOC100491547
gene id: 8364:LOC100491547
uniprot id: A0A6I8SPW3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

8364:hsd11b1l
gene id: 8364:hsd11b1l
uniprot id: A4IGM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Secreted

8364:mcm7
gene id: 8364:mcm7
uniprot id: A0A1B8Y939
uniprot id: Q6NX31
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. The existence of maternal and zygotic forms of mcm3 and mcm6 suggests that specific forms of mcm2-7 complexes may be used during different stages of development (By similarity).
messages: Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. The existence of maternal and zygotic forms of mcm3 and mcm6 suggests that specific forms of mcm2-7 complexes may be used during different stages of development.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the mcm2-7 complex (RLF-M). The complex forms a toroidal hexameric ring with the proposed subunit order mcm2-mcm6-mcm4-mcm7-mcm3-mcm5. The heterodimer of mmcm3/mcm5 interacts with mcm4, mmcm6, mcm7 and weakly with mcm2. The N-terminus is required for interaction with mmcm3, though this interaction may not be direct, and remains in a complex with mmcm3 throughout the cell cycle. Begins to associate with zmcm6 at the neurula stage (By similarity). Component of the replisome complex (By similarity). Component of the CMG helicase complex, composed of the mcm2-7 complex, the GINS complex and cdc45 (By similarity).
messages: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.
messages: Nucleus
messages: Ubiquitinated by traip when forks converge following formation of DNA interstrand cross-links. Short ubiquitin chains on mcm7 promote recruitment of DNA glycosylase neil3. If the interstrand cross-link cannot be cleaved by neil3, the ubiquitin chains continue to grow on mcm7, promoting the unloading of the CMG helicase complex by the vcp/p97 ATPase.

8364:LOC100497148
gene id: 8364:LOC100497148
uniprot id: A0A6I8QZ05
names: Similarity
messages: Belongs to the dermatopontin family.

8364:dgka
gene id: 8364:dgka
uniprot id: F7DBT3
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic diacylglycerol kinase family.
messages: Monomer.

8364:LOC116410335
gene id: 8364:LOC116410335
uniprot id: A0A8J1JF18
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:LOC116409559
gene id: 8364:LOC116409559
uniprot id: A0A8J1JAQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:txnl4b
gene id: 8364:txnl4b
uniprot id: Q28GF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

8364:cenps
gene id: 8364:cenps
uniprot id: A0A803K543
names: Similarity
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.

8364:LOC116409610
gene id: 8364:LOC116409610
uniprot id: A0A8J1J8L2
names: Subcellular Location Annotation
messages: Membrane

8364:tasp1
gene id: 8364:tasp1
uniprot id: A0A8J0SND4
uniprot id: B1WAX5
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

8364:ces3.1
gene id: 8364:ces3.1
uniprot id: B0BM77
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

8364:LOC619594
gene id: 8364:LOC619594
uniprot id: A0A8J1JW38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8364:pde8b
gene id: 8364:pde8b
uniprot id: A0A7D9NKC6
uniprot id: A0A8J0QZE5
uniprot id: A0A8J0QZT4
uniprot id: A0A8J0SJH6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8364:clcn2
gene id: 8364:clcn2
uniprot id: A0A6I8QHQ1
uniprot id: A0A8J0R4K6
uniprot id: F6V0E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.
messages: Cell membrane
messages: Membrane

8364:six3
gene id: 8364:six3
uniprot id: F7D0D8
names: Subcellular Location Annotation
messages: Nucleus

8364:gpr1
gene id: 8364:gpr1
uniprot id: A0A803JQH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

8364:cpsf2
gene id: 8364:cpsf2
uniprot id: B1H337
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

8364:tox4
gene id: 8364:tox4
uniprot id: A4QNP0
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100486918
gene id: 8364:LOC100486918
uniprot id: A0A7D9NJU9
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

8364:sdc4
gene id: 8364:sdc4
uniprot id: B0BM67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Membrane

8364:sucla2
gene id: 8364:sucla2
uniprot id: Q6P4J7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.
messages: Mitochondrion

8364:dclk2
gene id: 8364:dclk2
uniprot id: A0A6I8R2X1
uniprot id: A0A6I8SG33
uniprot id: A0A8J1J0I1
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

8364:gpr17
gene id: 8364:gpr17
uniprot id: A0A803J9N6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:ndufaf2
gene id: 8364:ndufaf2
uniprot id: F7BZZ2
names: Similarity
messages: Belongs to the complex I NDUFA12 subunit family.

8364:LOC733765
gene id: 8364:LOC733765
uniprot id: Q28FL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

8364:prkx
gene id: 8364:prkx
uniprot id: F6V5J2
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC100490485
gene id: 8364:LOC100490485
uniprot id: A0A8J0SW49
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:slc4a2
gene id: 8364:slc4a2
uniprot id: A0A803JDA2
uniprot id: A0A803K264
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Membrane

8364:LOC116412160
gene id: 8364:LOC116412160
uniprot id: A0A8J1JX88
names: Subcellular Location Annotation
messages: Membrane

8364:LOC116406490
gene id: 8364:LOC116406490
uniprot id: A0A8J1ISZ8
names: Subcellular Location Annotation
messages: Membrane

8364:cdk1
gene id: 8364:cdk1
uniprot id: Q6P7L3
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC100497391
gene id: 8364:LOC100497391
uniprot id: A0A8J0QVJ5
names: Similarity
messages: Belongs to the AccD/PCCB family.

8364:golim4
gene id: 8364:golim4
uniprot id: Q08D19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLIM4 family.
messages: Endosome membrane
messages: Golgi stack membrane
messages: May play a role in endosome to Golgi protein trafficking.

8364:LOC100485137
gene id: 8364:LOC100485137
uniprot id: A0A8J1IYR3
names: Subcellular Location Annotation
messages: Nucleus

8364:fam50a
gene id: 8364:fam50a
uniprot id: Q28BK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM50 family.
messages: Nucleus
messages: Probably involved in the regulation of pre-mRNA splicing.

8364:hnf1a
gene id: 8364:hnf1a
uniprot id: B1WB01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HNF1 homeobox family.
messages: Nucleus

8364:cct5
gene id: 8364:cct5
uniprot id: A0A803KHP1
uniprot id: Q6P2Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

8364:LOC100498440
gene id: 8364:LOC100498440
uniprot id: A0A803JD31
uniprot id: A0A8J0QY68
uniprot id: A0A8J0QYR5
uniprot id: A0A8J0R0A6
uniprot id: A0A8J0R2E2
uniprot id: A0A8J0R356
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

8364:LOC116406645
gene id: 8364:LOC116406645
uniprot id: A0A803K4R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

8364:ube2g2
gene id: 8364:ube2g2
uniprot id: Q28I82
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8364:LOC100485997
gene id: 8364:LOC100485997
uniprot id: A0A803KAD3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:chrng
gene id: 8364:chrng
uniprot id: A4QNB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:dus4l
gene id: 8364:dus4l
uniprot id: A0A8J0T1H5
uniprot id: Q28G52
uniprot id: Q66KJ0
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

8364:LOC101731479
gene id: 8364:LOC101731479
uniprot id: A0A8J0R585
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:clptm1
gene id: 8364:clptm1
uniprot id: A0A6I8Q2F9
uniprot id: A0A8J0R6V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

8364:magi3
gene id: 8364:magi3
uniprot id: A0A6I8R3D1
uniprot id: A1A5G4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes.
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Membrane
messages: tight junction

8364:fam3c
gene id: 8364:fam3c
uniprot id: A0A8J0SIK6
uniprot id: B0BLS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Involved in retinal laminar formation.
messages: Secreted

8364:mtap
gene id: 8364:mtap
uniprot id: A0A5S6KRA5
uniprot id: A0A803KL15
uniprot id: A0A8J0T358
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

8364:pax9
gene id: 8364:pax9
uniprot id: A0A6I8R708
names: Subcellular Location Annotation
messages: Nucleus

8364:lamb1
gene id: 8364:lamb1
uniprot id: A0A8J0QLR4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

8364:LOC116409576
gene id: 8364:LOC116409576
uniprot id: A0A8J1J8G7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:bsk146
gene id: 8364:bsk146
uniprot id: F6VK53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm

8364:LOC116412179
gene id: 8364:LOC116412179
uniprot id: A0A8J1JUX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:gje1
gene id: 8364:gje1
uniprot id: A0A803KD34
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:ctse
gene id: 8364:ctse
uniprot id: F7EHV9
names: Similarity
messages: Belongs to the peptidase A1 family.

8364:LOC116406821
gene id: 8364:LOC116406821
uniprot id: A0A8J1IPS9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:rpa2
gene id: 8364:rpa2
uniprot id: Q6DFS2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
messages: Belongs to the replication factor A protein 2 family.
messages: Component of the replication protein A complex (RPA/RP-A), a heterotrimeric complex composed of RPA1, RPA2 and RPA3.
messages: Differentially phosphorylated throughout the cell cycle, becoming phosphorylated at the G1-S transition and dephosphorylated in late mitosis. Phosphorylation increases upon replication fork stalling (By similarity).
messages: Nucleus
messages: PML body

8364:fgfr1op
gene id: 8364:fgfr1op
uniprot id: A0A6I8PY26
uniprot id: A0A803JKY7
uniprot id: A0A8J0SE77
uniprot id: A0A8J0SNV2
uniprot id: A0A8J0SNX9
uniprot id: A0A8J0T0T6
uniprot id: A0A8J0T2U0
uniprot id: A0A8J0T423
uniprot id: F6XAE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: cilium basal body

8364:elavl1
gene id: 8364:elavl1
uniprot id: Q6GLB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM elav family.
messages: Cytoplasm
messages: Interacts (via RRM3) with cirbp. Unable to form oligomers. Part of a ribonucleoprotein (RNP) complex, at least composed of elavl1/elrA and/or elavl2/elrB, igf2bp3/vg1RBP, ddx6/Xp54, ybx2/frgy2, lsm14b/rap55b and, in a subset of RNP complexes, stau1/staufen (By similarity).
messages: RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Acts cooperatively with cribp to stabilize AU-rich sequence (ARE)-containing mRNAs. May play a role during gastrulation. Required for the vegetal localization of vg1 mRNA (By similarity).
messages: cell cortex

8364:LOC100492139
gene id: 8364:LOC100492139
uniprot id: A0A8J0QT35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8364:ctsc
gene id: 8364:ctsc
uniprot id: Q28H13
uniprot id: Q4QQR0
names: Similarity
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.

8364:faslg
gene id: 8364:faslg
uniprot id: A0A6I8QWZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Cytoplasmic form induces gene transcription inhibition.
messages: Cytoplasmic vesicle lumen
messages: Lysosome lumen
messages: Nucleus
messages: Secreted

8364:wdr18
gene id: 8364:wdr18
uniprot id: Q28IR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat IPI3/WDR18 family.
messages: Dynein axonemal particle
messages: nucleolus
messages: nucleoplasm

8364:slc26a9
gene id: 8364:slc26a9
uniprot id: A0A8J1J358
uniprot id: A0A8J1J455
uniprot id: A4IIF2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Endomembrane system
messages: Homodimer.
messages: Inhibited by ammonium and thiosulfate.
messages: Ion transporter that can act both as an ion channel and anion exchanger. Mainly acts as a chloride channel, which mediate uncoupled chloride anion transport in an alternate-access mechanism where a saturable binding site is alternately exposed to either one or the other side of the membrane. Also acts as a DIDS- and thiosulfate- sensitive anion exchanger the exchange of chloride for bicarbonate ions across the cell membrane.
messages: Membrane

8364:hoxb6
gene id: 8364:hoxb6
uniprot id: F6Q890
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

8364:senp8
gene id: 8364:senp8
uniprot id: L7MUH7
names: Similarity
messages: Belongs to the peptidase C48 family.

8364:sorl1
gene id: 8364:sorl1
uniprot id: F6Y0W9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS10-related sortilin family. SORL1 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Recycling endosome membrane
messages: Secreted
messages: multivesicular body membrane
messages: secretory vesicle membrane
messages: trans-Golgi network membrane

8364:ptger4
gene id: 8364:ptger4
uniprot id: B1WAT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FEM1A.
messages: Membrane
messages: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

8364:cnksr1
gene id: 8364:cnksr1
uniprot id: A0A803JVM8
uniprot id: B1WAU1
names: Similarity
messages: Belongs to the CNKSR family.

8364:LOC100493148
gene id: 8364:LOC100493148
uniprot id: A0A803KA53
uniprot id: A0A8J1J302
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:abcb7
gene id: 8364:abcb7
uniprot id: A0A6I8STI5
names: Subcellular Location Annotation
messages: Membrane

8364:vn1r1
gene id: 8364:vn1r1
uniprot id: A0A803JV72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:ambn
gene id: 8364:ambn
uniprot id: F7A2E2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ameloblastin family.
messages: Involved in the mineralization and structural organization of enamel.
messages: extracellular matrix

8364:anxa1.3
gene id: 8364:anxa1.3
uniprot id: F7B2X0
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

8364:LOC116409648
gene id: 8364:LOC116409648
uniprot id: A0A8J1JC61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:trim54
gene id: 8364:trim54
uniprot id: A0A8J1JIV9
names: Function
names: Subcellular Location Annotation
messages: May bind and stabilize microtubules during myotubes formation.
messages: Z line

8364:golph3l
gene id: 8364:golph3l
uniprot id: A0A803JGJ0
uniprot id: Q5U4Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Homooligomer.
messages: Membrane
messages: Phosphatidylinositol-4-phosphate-binding protein that may play a role in the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane.
messages: trans-Golgi network membrane

8364:surf6
gene id: 8364:surf6
uniprot id: A0A1B8Y594
uniprot id: A0A803KH64
uniprot id: Q68F76
names: Similarity
messages: Belongs to the SURF6 family.

8364:LOC108648772
gene id: 8364:LOC108648772
uniprot id: A0A8J1IT33
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC105946102
gene id: 8364:LOC105946102
uniprot id: A0A8J1JEN6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:sfmbt2
gene id: 8364:sfmbt2
uniprot id: A0A6I8RUF3
uniprot id: F6XFP7
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100495521
gene id: 8364:LOC100495521
uniprot id: A0A8J0T2N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

8364:LOC101733857
gene id: 8364:LOC101733857
uniprot id: A0A803J879
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:fam207a
gene id: 8364:fam207a
uniprot id: A0A8J0T5P9
uniprot id: A8E5T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLX9 family.
messages: nucleolus

8364:mxd1
gene id: 8364:mxd1
uniprot id: Q0VFI9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (By similarity).
messages: Nucleus
messages: Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus antagonizes MYC transcriptional activity by competing for MAX (By similarity).

8364:LOC101731882
gene id: 8364:LOC101731882
uniprot id: A0A8J0R156
uniprot id: A0A8J0R389
names: Similarity
messages: Belongs to the FAM154 family.

8364:tmem218
gene id: 8364:tmem218
uniprot id: B0JYX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM218 family.
messages: May be involved in ciliary biogenesis or function.
messages: Membrane
messages: cilium

8364:palm3
gene id: 8364:palm3
uniprot id: F6WLF6
names: Similarity
messages: Belongs to the paralemmin family.

8364:mon1a
gene id: 8364:mon1a
uniprot id: F6XF57
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

8364:tsr2
gene id: 8364:tsr2
uniprot id: A0A6I8PMW7
uniprot id: A0A8J0SWF1
names: Function
names: Similarity
messages: Belongs to the TSR2 family.
messages: May be involved in 20S pre-rRNA processing.

8364:gosr2
gene id: 8364:gosr2
uniprot id: A0A6I8RQ07
uniprot id: A9UMT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOSR2 family.
messages: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
messages: Membrane

8364:kcnk6
gene id: 8364:kcnk6
uniprot id: F6SQB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Endosome
messages: Membrane
messages: Perikaryon
messages: Recycling endosome
messages: Synaptic cell membrane
messages: Vesicle
messages: dendrite

8364:crebbp
gene id: 8364:crebbp
uniprot id: A0A8J0QHP4
names: Subcellular Location Annotation
messages: Cytoplasm

8364:tes
gene id: 8364:tes
uniprot id: Q6DIR5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prickle / espinas / testin family.
messages: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. May inhibit cell growth (By similarity). Regulates cranial neural crest migration. Acts together with prickle1 to control axial elongation (By similarity).
messages: The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with other proteins.
messages: cell cortex
messages: focal adhesion

8364:smg5
gene id: 8364:smg5
uniprot id: Q05B16
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in nonsense-mediated mRNA decay.

8364:fam122b
gene id: 8364:fam122b
uniprot id: Q28D59
names: Similarity
messages: Belongs to the FAM122 family.

8364:palm
gene id: 8364:palm
uniprot id: F7DG87
uniprot id: F7DKE3
names: Similarity
messages: Belongs to the paralemmin family.

8364:cacna1c
gene id: 8364:cacna1c
uniprot id: A0A6I8SNV9
uniprot id: A0A8J0QX71
uniprot id: A0A8J0QZB1
uniprot id: A0A8J0R253
uniprot id: A0A8J0S9X9
uniprot id: A0A8J1J9B3
uniprot id: A0A8J1J9B4
uniprot id: A0A8J1J9B7
uniprot id: A0A8J1J9B8
uniprot id: A0A8J1J9C2
uniprot id: A0A8J1JBS3
uniprot id: A0A8J1JCV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily.
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic density membrane
messages: T-tubule
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.
messages: dendrite
messages: sarcolemma

8364:LOC105947845
gene id: 8364:LOC105947845
uniprot id: A0A8J0SRL2
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:gfral
gene id: 8364:gfral
uniprot id: A0A8J1JPP7
names: Similarity
messages: Belongs to the GDNFR family.

8364:pih1d1
gene id: 8364:pih1d1
uniprot id: A9ULC5
uniprot id: F6WDA6
names: Similarity
messages: Belongs to the PIH1 family.

8364:syne4
gene id: 8364:syne4
uniprot id: A0A803JPD7
names: Similarity
messages: Belongs to the nesprin family.

8364:ift122
gene id: 8364:ift122
uniprot id: A8WGF4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the IFT complex A (IFT-A) complex.
messages: Required for cilia formation during embryonal development. Acts as a negative regulator of Shh signaling.
messages: cilium
messages: cilium basal body

8364:LOC116406817
gene id: 8364:LOC116406817
uniprot id: A0A8J1ISY3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:t2r23
gene id: 8364:t2r23
uniprot id: Q2AB60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:tsen2
gene id: 8364:tsen2
uniprot id: A0A8J1JGY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

8364:rps15
gene id: 8364:rps15
uniprot id: Q5RJJ6
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Component of the small ribosomal subunit.

8364:LOC100486100
gene id: 8364:LOC100486100
uniprot id: A0A8J0QY95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:smpdl3a
gene id: 8364:smpdl3a
uniprot id: A0A8J0SMS7
uniprot id: F6TK08
uniprot id: Q5BKG9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

8364:brca1
gene id: 8364:brca1
uniprot id: A0A6I8PS34
uniprot id: B0JZF7
names: Subcellular Location Annotation
messages: Chromosome
messages: Cytoplasm
messages: Nucleus

8364:ovca2
gene id: 8364:ovca2
uniprot id: A8E5P8
names: Similarity
messages: Belongs to the LovG family.

8364:LOC100488102
gene id: 8364:LOC100488102
uniprot id: A0A6I8QDZ9
uniprot id: A0A8J1JNB5
names: Similarity
messages: Belongs to the dynein heavy chain family.

8364:rundc3b
gene id: 8364:rundc3b
uniprot id: Q6P631
names: Similarity
messages: Belongs to the RUNDC3 family.

8364:sv2a
gene id: 8364:sv2a
uniprot id: F6QL25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

8364:dhx9
gene id: 8364:dhx9
uniprot id: A0A8J0SM75
uniprot id: F6V9Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Nucleus

8364:pitpnm2
gene id: 8364:pitpnm2
uniprot id: A0A6I8RW11
uniprot id: A0A8J0S8B5
uniprot id: A0A8J0SFH9
uniprot id: A0A8J0SGK1
uniprot id: A0A8J0SGK8
uniprot id: A0A8J1J399
uniprot id: A0A8J1J3B3
uniprot id: A0A8J1J3C2
uniprot id: A0A8J1J3D3
uniprot id: A0A8J1J5T0
uniprot id: A0A8J1J5T9
uniprot id: B5DE79
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

8364:tff3.1
gene id: 8364:tff3.1
uniprot id: A0A7D9N0J2
names: Subcellular Location Annotation
messages: Secreted

8364:get1
gene id: 8364:get1
uniprot id: Q6DD99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WRB/GET1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:arf1
gene id: 8364:arf1
uniprot id: Q6NT85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

8364:slc9a2l
gene id: 8364:slc9a2l
uniprot id: A0A8J1IR07
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

8364:stam
gene id: 8364:stam
uniprot id: A0A6I8SFX0
uniprot id: A0A8J0SMT0
uniprot id: A0A8J1JMP6
uniprot id: Q6P3N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane

8364:tmem87b
gene id: 8364:tmem87b
uniprot id: B4F6P5
uniprot id: Q28EW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LU7TM family. TMEM87 subfamily.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN) (By similarity). In one study, shown to be a component of a novel mechanoelectrical transduction pathway which is involved in cell adhesion and migration, and is thought to act either as a mechanically activated ion channel or as an accessory protein which modulates an unidentified mechanically activated ion channel (By similarity). In another study, neither basal nor mechanically activated channel activity has been observed and, based on structural similarity with WLS, has been suggested to function as a trafficking chaperone for membrane-associated cargo (By similarity).
messages: Membrane

8364:adam11
gene id: 8364:adam11
uniprot id: E2ICL6
uniprot id: F6X3E3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC108644818
gene id: 8364:LOC108644818
uniprot id: A0A8J1IZP8
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:ccr7
gene id: 8364:ccr7
uniprot id: A0A803KBJ4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:LOC100488021
gene id: 8364:LOC100488021
uniprot id: A0A6I8R705
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:slc5a10
gene id: 8364:slc5a10
uniprot id: A0A6I8QS64
uniprot id: A0A6I8RA75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

8364:xrcc4
gene id: 8364:xrcc4
uniprot id: A0A803JCE9
uniprot id: A8WH10
uniprot id: B1H122
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XRCC4 subfamily.
messages: Nucleus

8364:lamtor3-like
gene id: 8364:lamtor3-like
uniprot id: B4F6Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.
messages: Belongs to the LAMTOR3 family.
messages: Late endosome membrane
messages: Part of the Ragulator complex composed of lamtor1, lamtor2, lamtor3, lamtor4 and lamtor5. The Ragulator complex interacts with slc38a9; the probable amino acid sensor. Component of the lysosomal folliculin complex (LFC).

8364:bmpr1a
gene id: 8364:bmpr1a
uniprot id: A0A6I8RP84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

8364:aldh3a2
gene id: 8364:aldh3a2
uniprot id: A0A8J0S7P0
uniprot id: A0A8J0SCN1
uniprot id: Q5BKL3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

8364:lin28a
gene id: 8364:lin28a
uniprot id: A0A8J0SCH7
uniprot id: B4F6Z2
uniprot id: G1K3F3
uniprot id: Q5EB47
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lin-28 family.
messages: Cytoplasm
messages: Monomer.
messages: P-body
messages: RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Suppressor of microRNA (miRNA) biogenesis, including that of let-7. Binds specific target miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in their terminal loop, and recruits uridylyltransferase. This results in the terminal uridylation of target pre-miRNAs. Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation (By similarity). Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins. Binds to and enhances the translation of mRNAs for several metabolic enzymes, increasing glycolysis and oxidative phosphorylation. Which, with the let-7 repression may enhance tissue repair in adult tissue (By similarity).
messages: Rough endoplasmic reticulum
messages: Stress granule
messages: The CCHC zinc fingers interact with the GGAG motif at the 3' end of let-7 miRNAs precursors, more generally they bind the 5'-NGNNG-3' consensus motif with micromolar affinity. The CSD domain recognizes the loop at the 5' end. The flexible linker allows accommodating variable sequences and lengths among let-7 family members (By similarity).
messages: nucleolus

8364:kcnj9
gene id: 8364:kcnj9
uniprot id: A4IIH3
uniprot id: F7AJ43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

8364:LOC116409628
gene id: 8364:LOC116409628
uniprot id: A0A8J1J8M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC733566
gene id: 8364:LOC733566
uniprot id: L7MUK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: nucleoplasm

8364:tmem211
gene id: 8364:tmem211
uniprot id: A9UL59
uniprot id: B7ZUP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM211 family.
messages: Membrane

8364:gal3st4.2
gene id: 8364:gal3st4.2
uniprot id: A0A6I8Q9Y6
uniprot id: A0A8J0SBP8
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

8364:gip
gene id: 8364:gip
uniprot id: A0A6I8PZZ0
uniprot id: A1DPK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
messages: Secreted

8364:slc20a2
gene id: 8364:slc20a2
uniprot id: A0A6I8R9M0
uniprot id: A0A8J1JDV6
uniprot id: Q28E01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane
messages: Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion.
messages: Sodium-phosphate symporter.

8364:LOC116412169
gene id: 8364:LOC116412169
uniprot id: A0A8J1JUV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:rfx3
gene id: 8364:rfx3
uniprot id: A0A6I8RJL4
uniprot id: A0A6I8S2M0
uniprot id: A0A8J0SR24
uniprot id: A0A8J0SR79
uniprot id: A0A8J0SR84
uniprot id: A0A8J0SR89
uniprot id: Q0V9K5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFX family.
messages: Nucleus
messages: Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development.

8364:stab2
gene id: 8364:stab2
uniprot id: A0A8J1JA36
uniprot id: F6QGU9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:lrp1b
gene id: 8364:lrp1b
uniprot id: A0A8J1IUU2
names: Caution
names: Similarity
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:f8
gene id: 8364:f8
uniprot id: A0A8J0SXK5
names: Similarity
messages: Belongs to the multicopper oxidase family.

8364:pros1
gene id: 8364:pros1
uniprot id: B2GUS2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:myo3b
gene id: 8364:myo3b
uniprot id: A0A8J0SPC9
uniprot id: A0A8J1IUD6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:LOC100496837
gene id: 8364:LOC100496837
uniprot id: A0A6I8Q7F2
names: Subcellular Location Annotation
messages: Membrane

8364:h1-3
gene id: 8364:h1-3
uniprot id: Q28FT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:ag1
gene id: 8364:ag1
uniprot id: Q6NVS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AGR family.
messages: Probably involved in cement gland formation.
messages: Secreted

8364:tmem121
gene id: 8364:tmem121
uniprot id: A0A803JHW2
names: Similarity
messages: Belongs to the TMEM121 family.

8364:LOC100486032
gene id: 8364:LOC100486032
uniprot id: A0A6I8QNN8
names: Subcellular Location Annotation
messages: Nucleus

8364:srd5a1
gene id: 8364:srd5a1
uniprot id: Q6DF23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane
messages: Microsome membrane

8364:cript
gene id: 8364:cript
uniprot id: F7CUQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRIPT family.
messages: Cytoplasm

8364:proca1
gene id: 8364:proca1
uniprot id: A0A8J1J3U8
names: Subcellular Location Annotation
messages: Secreted

8364:LOC779590
gene id: 8364:LOC779590
uniprot id: A9JTJ7
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8364:kiaa2013
gene id: 8364:kiaa2013
uniprot id: A4IH88
names: Subcellular Location Annotation
messages: Membrane

8364:arf11l.2
gene id: 8364:arf11l.2
uniprot id: A0A803JBN5
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

8364:LOC108645658
gene id: 8364:LOC108645658
uniprot id: A0A8J0T188
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:mpdz
gene id: 8364:mpdz
uniprot id: A0A6I8RK58
uniprot id: A0A6I8S5T5
uniprot id: A0A6I8SY11
uniprot id: A0A8J0S5F1
uniprot id: A0A8J0S9L6
uniprot id: A0A8J0S9M3
uniprot id: A0A8J0SB63
uniprot id: A0A8J0SB75
uniprot id: A0A8J0SB79
uniprot id: A0A8J0SBT4
uniprot id: A0A8J0T6K0
names: Subcellular Location Annotation
messages: tight junction

8364:ventx1.1
gene id: 8364:ventx1.1
uniprot id: B0BME3
names: Subcellular Location Annotation
messages: Nucleus

8364:st3gal2.2
gene id: 8364:st3gal2.2
uniprot id: F6RJ90
uniprot id: Q70D56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8364:upf1
gene id: 8364:upf1
uniprot id: A0A6I8T1P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Cytoplasm

8364:slc15a2
gene id: 8364:slc15a2
uniprot id: F6U3E4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

8364:tlr2
gene id: 8364:tlr2
uniprot id: A0A803JIX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
messages: Membrane

8364:LOC100493232
gene id: 8364:LOC100493232
uniprot id: A0A6I8RCG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

8364:pcyt1a
gene id: 8364:pcyt1a
uniprot id: A0A8J1JNG7
uniprot id: F7DAV8
names: Function
names: Similarity
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.

8364:foxj2
gene id: 8364:foxj2
uniprot id: A0A803JN51
uniprot id: A0A8J1JSF1
uniprot id: Q28EM1
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed broadly prior to stage 23, after which expression becomes restricted to dorsal tissues. By stage 28, restricted to the notochord and floorplate. Expressed almost exclusively in the most ventral part of the neural tube in anterior regions of the embryo. In posterior regions, expressed more dorsally in the neural tube. At stage 35, expression remains in the notochord, neural tube and brain.
messages: Nucleus
messages: Transcriptional activator.

8364:psip1
gene id: 8364:psip1
uniprot id: A0A6I8SIT5
uniprot id: A0A8J0S6U9
uniprot id: A0A8J0S6V3
uniprot id: A0A8J0SEA4
uniprot id: B1H2S8
uniprot id: F6TAG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HDGF family.
messages: Nucleus

8364:ssbp3
gene id: 8364:ssbp3
uniprot id: A0A8J1JD48
uniprot id: A0JLY6
uniprot id: B4F6Z1
uniprot id: Q28CH5
uniprot id: Q6P4M2
names: Subcellular Location Annotation
messages: Nucleus

8364:epha6
gene id: 8364:epha6
uniprot id: A0A8J0T0X0
uniprot id: A0A8J1J3L3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC100488386
gene id: 8364:LOC100488386
uniprot id: A0A8J0QKR6
uniprot id: A0A8J0SJF7
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:mrpl46
gene id: 8364:mrpl46
uniprot id: A4QNB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Mitochondrion

8364:LOC100497142
gene id: 8364:LOC100497142
uniprot id: A0A803JSS0
uniprot id: A0A8J0QLK8
uniprot id: A0A8J0SXM4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8364:arhgap26
gene id: 8364:arhgap26
uniprot id: A0A6I8QLX2
uniprot id: A0A8J1J6K0
uniprot id: B5DFQ4
names: Function
names: Subcellular Location Annotation
messages: GTPase-activating protein for rhoa and cdc42.
messages: cytoskeleton
messages: focal adhesion

8364:lamtor2
gene id: 8364:lamtor2
uniprot id: Q6DF40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.
messages: Belongs to the GAMAD family.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Part of the Ragulator complex composed of lamtor1, lamtor2, lamtor3, lamtor4 and lamtor5. The Ragulator complex interacts with slc38a9; the probable amino acid sensor. Component of the lysosomal folliculin complex (LFC).

8364:cachd1
gene id: 8364:cachd1
uniprot id: A0A6I8RQX0
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

8364:ighmbp2
gene id: 8364:ighmbp2
uniprot id: A0A6I8Q959
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family.

8364:rbm26
gene id: 8364:rbm26
uniprot id: Q6NVP4
names: Subcellular Location Annotation
messages: Nucleus

8364:ggh
gene id: 8364:ggh
uniprot id: Q5BKJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C26 family.
messages: extracellular space

8364:daxx
gene id: 8364:daxx
uniprot id: F6RWB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAXX family.
messages: Cytoplasm
messages: PML body
messages: centromere
messages: nucleolus
messages: nucleoplasm

8364:LOC100490338
gene id: 8364:LOC100490338
uniprot id: F6YLF9
names: Similarity
messages: Belongs to the ARTD/PARP family.

8364:mtmr10
gene id: 8364:mtmr10
uniprot id: A0A8J1J6Q4
uniprot id: A0A8J1J6Q6
uniprot id: B3DLZ6
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

8364:taf1b
gene id: 8364:taf1b
uniprot id: F7BLM1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Although it shares weak sequence similarity with GTF2B/TFIIB, displays a similar subdomain organization as GTF2B/TFIIB, with a N-terminal zinc finger, a connecting region (composed of B-reader and B-linker regions), followed by 2 cyclin folds. The RRN7-type zinc finger plays an essential postrecruitment role in Pol I transcription at a step preceding synthesis of the first 40 nucleotides (By similarity).
messages: Belongs to the RRN7/TAF1B family.
messages: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment (By similarity).
messages: nucleolus

8364:otop1
gene id: 8364:otop1
uniprot id: A0A8J0SE01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

8364:nr2f6
gene id: 8364:nr2f6
uniprot id: Q6GL59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

8364:scarf1
gene id: 8364:scarf1
uniprot id: F6YYE2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:xkr7
gene id: 8364:xkr7
uniprot id: A0A8J1IYH1
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:usp14
gene id: 8364:usp14
uniprot id: A0A6I8RB51
uniprot id: F6XN95
names: Similarity
names: Subunit
messages: Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
messages: Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS.

8364:mindy1
gene id: 8364:mindy1
uniprot id: A0A6I8PUD6
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

8364:LOC100488377
gene id: 8364:LOC100488377
uniprot id: A0A8J0QYQ1
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC116409623
gene id: 8364:LOC116409623
uniprot id: A0A8J1JC36
names: Subcellular Location Annotation
messages: Membrane

8364:c6.1
gene id: 8364:c6.1
uniprot id: A0A6I8Q310
uniprot id: A0A8J1IX91
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:t2r13
gene id: 8364:t2r13
uniprot id: Q2AB69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:kdr
gene id: 8364:kdr
uniprot id: A0A6I8SF46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

8364:agap1
gene id: 8364:agap1
uniprot id: A0A6I8R0Y4
uniprot id: A0A6I8RJK7
uniprot id: A0A6I8SFK2
uniprot id: A0A6I8SSI0
uniprot id: A0A8J0QHS3
uniprot id: A0A8J0R4X3
names: Similarity
messages: Belongs to the centaurin gamma-like family.

8364:slc25a4
gene id: 8364:slc25a4
uniprot id: Q6P7N0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

8364:gclc
gene id: 8364:gclc
uniprot id: Q0V9R9
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

8364:atp11a
gene id: 8364:atp11a
uniprot id: A0A6I8R5Q1
uniprot id: A0A6I8R9L4
uniprot id: A0A8J1J793
uniprot id: A0A8J1J893
uniprot id: F6XT62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

8364:fam47e
gene id: 8364:fam47e
uniprot id: A9JTP4
names: Similarity
messages: Belongs to the FAM47 family.

8364:minar2
gene id: 8364:minar2
uniprot id: A0A6I8Q300
names: Similarity
messages: Belongs to the MINAR family.

8364:slc12a2
gene id: 8364:slc12a2
uniprot id: A0A6I8SIE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

8364:nfasc
gene id: 8364:nfasc
uniprot id: A0A6I8S169
uniprot id: A0A6I8T0W7
uniprot id: A0A8J0QZU1
uniprot id: A0A8J1J491
uniprot id: A0A8J1J499
uniprot id: A0A8J1J4A3
uniprot id: A0A8J1J4A4
uniprot id: A0A8J1J4A9
uniprot id: A0A8J1J4B4
uniprot id: A0A8J1J6N3
uniprot id: A0A8J1J6N9
uniprot id: A0A8J1J6P5
uniprot id: A0A8J1J7Q8
uniprot id: A0A8J1J7R3
names: Similarity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

8364:bckdha
gene id: 8364:bckdha
uniprot id: A0A8J0SRZ7
uniprot id: A0JPC4
names: Function
names: Similarity
messages: Belongs to the BCKDHA family.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

8364:vcl
gene id: 8364:vcl
uniprot id: A0A8J1JRL3
uniprot id: A0A8J1JRL4
uniprot id: A0A8J1JU22
uniprot id: A1L0Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction
messages: podosome

8364:camkmt
gene id: 8364:camkmt
uniprot id: A0A803KEW6
uniprot id: B7FEW8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:themis
gene id: 8364:themis
uniprot id: F6UMP6
names: Similarity
messages: Belongs to the themis family.

8364:dcaf11
gene id: 8364:dcaf11
uniprot id: A0A8J0S9X4
uniprot id: Q6DJB8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat LEC14B family.
messages: Interacts with DDB1 and CUL4A.
messages: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

8364:LOC100498331
gene id: 8364:LOC100498331
uniprot id: A0A6I8RHZ8
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

8364:LOC105946314
gene id: 8364:LOC105946314
uniprot id: A0A8J1J2J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC108648075
gene id: 8364:LOC108648075
uniprot id: A0A8J0T5J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:ppp4c
gene id: 8364:ppp4c
uniprot id: A0A1B8XWE3
uniprot id: Q6P861
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPP phosphatase family.
messages: Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Nucleus
messages: Protein phosphatase that regulates many processes such as microtubule organization at centrosomes.
messages: Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits.
messages: centrosome

8364:mat2b
gene id: 8364:mat2b
uniprot id: Q566L8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
messages: Heterotrimer; composed of a catalytic mat2a homodimer that binds one regulatory mat2b chain. Heterohexamer; composed of a central, catalytic mat2a homotetramer flanked on either side by a regulatory mat2b chain. NADP binding increases the affinity for mat2a.
messages: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. Can bind NADP (in vitro).

8364:LOC116406455
gene id: 8364:LOC116406455
uniprot id: A0A8J0QWK3
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:LOC100493218
gene id: 8364:LOC100493218
uniprot id: A0A803J3A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

8364:asxl2
gene id: 8364:asxl2
uniprot id: A0A803JBP5
uniprot id: A0A803KDS4
uniprot id: A0A8J0SZK4
uniprot id: A0A8J0T050
uniprot id: A0A8J1JM64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Asx family.
messages: Nucleus

8364:sgsm1
gene id: 8364:sgsm1
uniprot id: A0A6I8R496
uniprot id: A0A8J0T5Q7
uniprot id: A0A8J1JSI4
names: Similarity
messages: Belongs to the RUTBC family.

8364:dnah5
gene id: 8364:dnah5
uniprot id: A0A8J0SS00
uniprot id: A0A8J1JNU6
uniprot id: A0A8J1JSK5
names: Similarity
messages: Belongs to the dynein heavy chain family.

8364:arid3b
gene id: 8364:arid3b
uniprot id: A0A8J0R4Y4
uniprot id: F7B3D8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer.
messages: Nucleus
messages: Transcription factor.

8364:gabrg3
gene id: 8364:gabrg3
uniprot id: A0A803JLM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:LOC101731855
gene id: 8364:LOC101731855
uniprot id: A0A8J1J5C0
names: Similarity
messages: Belongs to the CD200R family.

8364:sgk2
gene id: 8364:sgk2
uniprot id: F6XY49
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC116406800
gene id: 8364:LOC116406800
uniprot id: A0A8J1IPQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8364:med4
gene id: 8364:med4
uniprot id: A0A7D9NJS9
uniprot id: Q5M8Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8364:LOC116411534
gene id: 8364:LOC116411534
uniprot id: A0A803JS36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

8364:elp4
gene id: 8364:elp4
uniprot id: A0A6I8QCJ1
uniprot id: A0A803K7V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP4 family.
messages: Cytoplasm
messages: Nucleus

8364:rhot2
gene id: 8364:rhot2
uniprot id: A0A8J0T6R6
uniprot id: Q6DIS1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).
messages: Mitochondrion outer membrane
messages: Ubiquitinated by PRKN in a PINK1-dependent manner, leading to its degradation.

8364:ppp1r14d
gene id: 8364:ppp1r14d
uniprot id: A0A803JM08
names: Similarity
messages: Belongs to the PP1 inhibitor family.

8364:dhrs7c
gene id: 8364:dhrs7c
uniprot id: A9UM79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Putative oxidoreductase.
messages: Secreted

8364:zbtb8a.1
gene id: 8364:zbtb8a.1
uniprot id: B1WAZ8
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

8364:neu3.2
gene id: 8364:neu3.2
uniprot id: A0A1B8Y474
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

8364:nmur2
gene id: 8364:nmur2
uniprot id: F7CAM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

8364:LOC116406636
gene id: 8364:LOC116406636
uniprot id: A0A6I8Q1H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Membrane
messages: Microsome membrane

8364:arl2
gene id: 8364:arl2
uniprot id: F7BJL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

8364:sgce
gene id: 8364:sgce
uniprot id: A0A6I8RWP5
uniprot id: A0A6I8T1M4
uniprot id: A0A803JDX1
uniprot id: A0A803KEP0
uniprot id: A0A8J0SQV6
uniprot id: A0A8J1JQ04
uniprot id: A0A8J1JTQ3
names: Function
names: Similarity
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

8364:orai2
gene id: 8364:orai2
uniprot id: A0A803KD49
uniprot id: A0A8J0SLK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

8364:gabarapl1
gene id: 8364:gabarapl1
uniprot id: Q5BIZ2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG8 family.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: The precursor molecule is cleaved by ATG4 (atg4a, atg4b, atg4c or atg4d) to expose the glycine at the C-terminus and form the cytosolic form, gabarapl1-I. The processed form is then activated by apg7l/atg7, transferred to atg3 and conjugated to phosphatidylethanolamine (PE) phospholipid to form the membrane-bound form, gabarapl1-II. During non-canonical autophagy, the processed form is conjugated to phosphatidylserine (PS) phospholipid. Atg4 proteins also mediate the delipidation of PE-conjugated forms required for gabarapl1 recycling when autophagosomes fuse with lysosomes. In addition, some atg4 proteins mediate delipidation of ATG8 proteins conjugated to PS during non-canonical autophagy.
messages: Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.
messages: autophagosome
messages: cytoskeleton

8364:gtf2a2
gene id: 8364:gtf2a2
uniprot id: Q6DEQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.

8364:nosip
gene id: 8364:nosip
uniprot id: Q6P829
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOSIP family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face (By similarity). Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity (By similarity).
messages: Nucleus

8364:tpm1
gene id: 8364:tpm1
uniprot id: A0A6I8RUR1
uniprot id: A0A6I8S6I6
uniprot id: A0A8J0SIH7
uniprot id: A0A8J0SQK2
uniprot id: A0A8J0SQK7
uniprot id: A0A8J0ST72
uniprot id: A0A8J0STI5
uniprot id: A0A8J1J751
uniprot id: A0A8J1J753
uniprot id: A0A8J1J755
uniprot id: A0A8J1JAL5
uniprot id: B1H2X3
uniprot id: Q6DFM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

8364:aste1
gene id: 8364:aste1
uniprot id: B2GUH0
names: Similarity
messages: Belongs to the asteroid family.

8364:sh2b1
gene id: 8364:sh2b1
uniprot id: A0A8J1IT86
uniprot id: A0A8J1IT88
uniprot id: A0A8J1IT95
uniprot id: A0A8J1IVN1
names: Similarity
messages: Belongs to the SH2B adapter family.

8364:cbr1.2
gene id: 8364:cbr1.2
uniprot id: A0A803JII7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8364:rab27b
gene id: 8364:rab27b
uniprot id: F6X4D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

8364:LOC116407943
gene id: 8364:LOC116407943
uniprot id: A0A219UQI0
names: Subcellular Location Annotation
messages: Secreted

8364:muc4
gene id: 8364:muc4
uniprot id: A0A6I8RGP7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:crybb3
gene id: 8364:crybb3
uniprot id: A0A8J0SXP8
uniprot id: A0A8J1IQA5
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:or11l1
gene id: 8364:or11l1
uniprot id: A0A8J0QPH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC105946248
gene id: 8364:LOC105946248
uniprot id: A0A8J0S6K8
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:LOC116411637
gene id: 8364:LOC116411637
uniprot id: B5DDY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:fcho1
gene id: 8364:fcho1
uniprot id: A0A6I8R644
uniprot id: A0A8J0QG37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FCHO family.
messages: clathrin-coated pit

8364:cep63
gene id: 8364:cep63
uniprot id: A0A803J758
uniprot id: A0A8J1JPF3
names: Similarity
messages: Belongs to the CEP63 family.

8364:smpd3
gene id: 8364:smpd3
uniprot id: F7BUA3
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

8364:umod.3
gene id: 8364:umod.3
uniprot id: A0A7D9NLQ9
names: Caution
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: cilium membrane

8364:gramd1b
gene id: 8364:gramd1b
uniprot id: A0A6I8RLG0
uniprot id: A0A6I8S9G7
uniprot id: A0A8J1JX07
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:mvb12a
gene id: 8364:mvb12a
uniprot id: A9JTN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MVB12 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

8364:LOC105946896
gene id: 8364:LOC105946896
uniprot id: A0A8J1INM4
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:des.1
gene id: 8364:des.1
uniprot id: Q6P869
names: Similarity
messages: Belongs to the intermediate filament family.

8364:gab3
gene id: 8364:gab3
uniprot id: A0A8J0SW96
uniprot id: A0A8J1IQA3
uniprot id: F6WU19
names: Similarity
messages: Belongs to the GAB family.

8364:tgm2
gene id: 8364:tgm2
uniprot id: B3DM72
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

8364:slc8b1
gene id: 8364:slc8b1
uniprot id: A0A8J0PIZ1
names: Subcellular Location Annotation
messages: Membrane

8364:st3gal3
gene id: 8364:st3gal3
uniprot id: A0A6I8S7N4
uniprot id: A0A8J0SJM2
uniprot id: A0A8J0SKT6
uniprot id: A0A8J0SKX6
uniprot id: A4IGP6
uniprot id: F6Z9V9
uniprot id: Q0P4X4
uniprot id: Q702R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8364:apln
gene id: 8364:apln
uniprot id: A9ULR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apelin family.
messages: extracellular space

8364:hk2
gene id: 8364:hk2
uniprot id: B1WAR7
names: Similarity
messages: Belongs to the hexokinase family.

8364:adamts14
gene id: 8364:adamts14
uniprot id: A0A6I8SGR0
uniprot id: A0A8J1JW31
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:bmp7.1
gene id: 8364:bmp7.1
uniprot id: Q6P4J4
names: Similarity
messages: Belongs to the TGF-beta family.

8364:pym1
gene id: 8364:pym1
uniprot id: B1WB17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pym family.
messages: Cytoplasm
messages: Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex (By similarity).
messages: Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions (By similarity).
messages: nucleolus
messages: nucleoplasm

8364:LOC116409818
gene id: 8364:LOC116409818
uniprot id: A0A8J1JBK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:LOC100497196
gene id: 8364:LOC100497196
uniprot id: A0A8J1K137
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

8364:clmp
gene id: 8364:clmp
uniprot id: Q640U3
names: Subcellular Location Annotation
messages: Cell membrane
messages: tight junction

8364:mafb
gene id: 8364:mafb
uniprot id: Q504L8
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional activator or repressor. Implicated in the regulation of cell-type specific gene expression and play a role in inductive events during lens development (By similarity).
messages: Belongs to the bZIP family. Maf subfamily.
messages: Expressed in the somites at stage 19 onwards. Expressed in the developing hindbrain between neural plate at stage 32. Expressed in the ventral blood islands from stage 22 until stage 28. Expressed in the condensing pronephros at stage 24. Expressed in the pronephric tubules at stage 33. Expressed in the presumptive lens-forming ectoderm (PLE) at stage 22 and during lens formation. Expressed in the invaginating placode at stage 28. Expressed in lens epithelia at stage 33. Expressed in the rhombencephalon at least until stage 40. Expressed in the olfactory bulb and the thalamus at stage 43. Expressed in the neural crest cells.
messages: Homodimer or heterodimer with other bHLH-Zip transcription factors. Binds DNA as a homodimer or a heterodimer (By similarity).
messages: Nucleus

8364:fam210a
gene id: 8364:fam210a
uniprot id: A4IJ20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM210 family.
messages: Cytoplasm
messages: May play a role in the structure and strength of both muscle and bone.
messages: Membrane
messages: Mitochondrion

8364:dynlt1
gene id: 8364:dynlt1
uniprot id: Q5I0R5
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

8364:LOC100491808
gene id: 8364:LOC100491808
uniprot id: A0A8J0QZ62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:rnasek
gene id: 8364:rnasek
uniprot id: F7DYQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase K family.
messages: Membrane

8364:rab3b
gene id: 8364:rab3b
uniprot id: A0A803KJM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

8364:crybg1
gene id: 8364:crybg1
uniprot id: A0A803JDJ1
uniprot id: A0A803JZ21
uniprot id: A0A803K060
uniprot id: F7AXB9
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:kmt5b
gene id: 8364:kmt5b
uniprot id: A0A7D9N0F6
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

8364:LOC100498180
gene id: 8364:LOC100498180
uniprot id: A0A8J1IPS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:psd3
gene id: 8364:psd3
uniprot id: A0A8J0QN33
uniprot id: A0A8J0S6D7
uniprot id: A0A8J1JQ85
uniprot id: A0A8J1JQ87
names: Subcellular Location Annotation
messages: ruffle membrane

8364:crybg2
gene id: 8364:crybg2
uniprot id: A0A6I8QIH0
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:e2f3
gene id: 8364:e2f3
uniprot id: Q5XGD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

8364:LOC734092
gene id: 8364:LOC734092
uniprot id: Q28BS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. The existence of maternal and zygotic forms of mcm3 and mcm6 suggests that specific forms of mcm2-7 complexes may be used during different stages of development (By similarity).
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the mcm2-7 complex (RLF-M). The complex forms a toroidal hexameric ring with the proposed subunit order mcm2-mcm6-mcm4-mcm7-mcm3-mcm5. Component of the CMG helicase complex, composed of the mcm2-7 complex, the GINS complex and cdc45.
messages: Nucleus

8364:sult1e1
gene id: 8364:sult1e1
uniprot id: A0A803KJR4
uniprot id: A0A8J0SLQ6
uniprot id: Q28HS2
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8364:rps4x
gene id: 8364:rps4x
uniprot id: A0A8J1IN17
uniprot id: Q6PBC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS4 family.
messages: Component of the small ribosomal subunit.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

8364:fgd3
gene id: 8364:fgd3
uniprot id: A0A6I8S184
uniprot id: A0A8J0R3D3
names: Subcellular Location Annotation
messages: cytoskeleton

8364:nop2
gene id: 8364:nop2
uniprot id: A0A8J0R5R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: nucleolus

8364:nodal1
gene id: 8364:nodal1
uniprot id: Q28GB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Cooperation and regulatory loops of multiple nodals are essential for mesendoderm patterning in early embryos. Essential for mesoderm formation and axial patterning during embryonic development. Activates the activin-like signaling pathway to induce dorsal and ventral mesoderm in animal cap ectoderm. In addition, also dorsalizes ventral marginal zone (VMZ) tissues during gastrulation. Acts in a downstream signaling cascade via cripto and cer1 to mediate cardiogenesis in embryonic mesoderm. Directs the orientation of the left-right axis by driving the left-specific gene cascade in the left lateral plate mesoderm (By similarity).
messages: Homodimer; disulfide-linked. Interacts with, and is inhibited by cer1 and gdf10/bmp3b.
messages: Secreted

8364:dlx1
gene id: 8364:dlx1
uniprot id: A0PJP5
names: Subcellular Location Annotation
messages: Nucleus

8364:cracr2b
gene id: 8364:cracr2b
uniprot id: A0JP75
names: Similarity
messages: Belongs to the EFCAB4 family.

8364:LOC100490478
gene id: 8364:LOC100490478
uniprot id: A0A8J0QJA6
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:LOC594909
gene id: 8364:LOC594909
uniprot id: A0A8J1JJ12
uniprot id: Q28EW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly.
messages: cytoskeleton

8364:rnf20
gene id: 8364:rnf20
uniprot id: A0A6I8QU87
uniprot id: A0A8J0QZL7
uniprot id: F6YPA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRE1 family.
messages: Nucleus

8364:hspe1
gene id: 8364:hspe1
uniprot id: F6QRL5
uniprot id: Q6DDD2
names: Similarity
messages: Belongs to the GroES chaperonin family.

8364:c12orf57
gene id: 8364:c12orf57
uniprot id: A0A8J1JS94
uniprot id: Q6P7L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0456 family.
messages: Cytoplasm

8364:unc13c
gene id: 8364:unc13c
uniprot id: A0A8J0T1X3
uniprot id: A0A8J1JAZ7
names: Subcellular Location Annotation
messages: Cytoplasm

8364:gipc3
gene id: 8364:gipc3
uniprot id: A4QNB3
names: Similarity
messages: Belongs to the GIPC family.

8364:LOC116406818
gene id: 8364:LOC116406818
uniprot id: A0A8J1IPT1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:tbl1x
gene id: 8364:tbl1x
uniprot id: B1H2M5
names: Similarity
messages: Belongs to the WD repeat EBI family.

8364:atr
gene id: 8364:atr
uniprot id: A0A8J1JK39
uniprot id: A0A8J1JMJ1
uniprot id: A0A8J1JNR4
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.

8364:zdhhc14
gene id: 8364:zdhhc14
uniprot id: A0A8J0R4C5
uniprot id: A0A8J0R4V1
uniprot id: A0A8J0SLZ4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8364:LOC116409549
gene id: 8364:LOC116409549
uniprot id: A0A8J1JBR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:capza2
gene id: 8364:capza2
uniprot id: Q07GA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

8364:LOC116406441
gene id: 8364:LOC116406441
uniprot id: A0A6I8T2N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:kcnt2
gene id: 8364:kcnt2
uniprot id: A0A803J638
uniprot id: A0A803JWY4
uniprot id: A0A8J1JIQ7
uniprot id: A0A8J1JJT6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:aldh5a1
gene id: 8364:aldh5a1
uniprot id: B4F708
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
messages: Homotetramer.
messages: Mitochondrion

8364:acox1
gene id: 8364:acox1
uniprot id: F6UF69
uniprot id: Q5EBF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

8364:vasp
gene id: 8364:vasp
uniprot id: Q66IM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: cytoskeleton

8364:LOC116406481
gene id: 8364:LOC116406481
uniprot id: A0A8J1IQ18
names: Similarity
messages: Belongs to the MHC class I family.

8364:htr1a
gene id: 8364:htr1a
uniprot id: F7E4L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:ptpn11
gene id: 8364:ptpn11
uniprot id: A0A6I8SAV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

8364:otulin
gene id: 8364:otulin
uniprot id: A0A8J0QIJ6
uniprot id: A0A8J0R092
uniprot id: A0A8J0R4Y2
uniprot id: A0A8J0R5D5
uniprot id: A0A8J1JTC2
uniprot id: F6S3V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

8364:cat1
gene id: 8364:cat1
uniprot id: A0A803K330
uniprot id: A0A803K997
uniprot id: A0A8J1JWM0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC116412347
gene id: 8364:LOC116412347
uniprot id: A0A8J1JWS3
names: Similarity
messages: Belongs to the FAM13 family.

8364:pex6
gene id: 8364:pex6
uniprot id: A0A8J1JNE8
names: Subcellular Location Annotation
messages: cytosol

8364:unc93b1
gene id: 8364:unc93b1
uniprot id: A0A6I8PYP0
uniprot id: A0A8J1JU84
uniprot id: A4IHH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

8364:fign
gene id: 8364:fign
uniprot id: A0A6I8RKM8
uniprot id: A0A8J0QM07
uniprot id: A0A8J0R2T8
uniprot id: A0A8J1IWE5
names: Similarity
messages: Belongs to the AAA ATPase family.

8364:cd38
gene id: 8364:cd38
uniprot id: Q5M8X2
names: Similarity
messages: Belongs to the ADP-ribosyl cyclase family.

8364:oaf
gene id: 8364:oaf
uniprot id: A0A8J0QMC3
uniprot id: A0A8J0R5P5
uniprot id: A0A8J0SU24
names: Similarity
messages: Belongs to the OAF family.

8364:serpinh1
gene id: 8364:serpinh1
uniprot id: A0A8J0QQ98
names: Function
names: Similarity
messages: Belongs to the serpin family.
messages: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

8364:LOC100492137
gene id: 8364:LOC100492137
uniprot id: A0A8J0SK03
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:star
gene id: 8364:star
uniprot id: A0A6I8Q7U2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: May interact with TSPO.
messages: Mitochondrion
messages: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.

8364:nfix
gene id: 8364:nfix
uniprot id: A0A6I8QTP2
uniprot id: A0A6I8S505
uniprot id: A0A803KKL0
uniprot id: A0A8J1J6N1
uniprot id: A0A8J1J6N6
uniprot id: B2GUB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

8364:jph3
gene id: 8364:jph3
uniprot id: F6RHZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

8364:nkx2-2
gene id: 8364:nkx2-2
uniprot id: A0A8J0R1U3
uniprot id: F6Y5I3
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC101734359
gene id: 8364:LOC101734359
uniprot id: A0A8J1JC81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100495703
gene id: 8364:LOC100495703
uniprot id: A0A8J0QWH3
names: Similarity
messages: Belongs to the MHC class I family.

8364:mcoln1
gene id: 8364:mcoln1
uniprot id: Q5M7Q9
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

8364:smc1b
gene id: 8364:smc1b
uniprot id: A0A803K4U6
uniprot id: A0A8J0QGL9
uniprot id: A0A8J1J6K8
uniprot id: B1H2G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family.
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

8364:hint2
gene id: 8364:hint2
uniprot id: A0A803JAB9
names: Similarity
messages: Belongs to the HINT family.

8364:cldn16
gene id: 8364:cldn16
uniprot id: A0A8J0QPA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8364:ifitm3
gene id: 8364:ifitm3
uniprot id: F7B6X6
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8364:mrpl19
gene id: 8364:mrpl19
uniprot id: F7AWN4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

8364:axin2
gene id: 8364:axin2
uniprot id: A0A8J0R5W6
uniprot id: F7ABT6
names: Subcellular Location Annotation
messages: Cytoplasm

8364:or5au1
gene id: 8364:or5au1
uniprot id: A0A8J0QLA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:stxbp5l
gene id: 8364:stxbp5l
uniprot id: A0A6I8QXN9
uniprot id: A0A6I8R8H1
uniprot id: A0A6I8R8S0
uniprot id: A0A6I8RL54
uniprot id: A0A6I8SC58
uniprot id: A0A8J0QX26
uniprot id: A0A8J0QZ66
uniprot id: A0A8J0R1A9
uniprot id: A0A8J1J369
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

8364:trim69.2
gene id: 8364:trim69.2
uniprot id: A0A803JGN7
uniprot id: Q28BY7
names: Subcellular Location Annotation
messages: Cytoplasm

8364:acadl
gene id: 8364:acadl
uniprot id: Q28BK3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Homotetramer.
messages: Mitochondrion matrix

8364:adipor1
gene id: 8364:adipor1
uniprot id: A0A8J0SK40
uniprot id: Q66KJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

8364:prpf4
gene id: 8364:prpf4
uniprot id: Q6P8A5
names: Subcellular Location Annotation
messages: Nucleus speckle

8364:cyp4f22
gene id: 8364:cyp4f22
uniprot id: A0A803KHH8
uniprot id: A0A8J0S7J6
uniprot id: A0A8J0SEG5
uniprot id: A0A8J0SFF1
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:tbca
gene id: 8364:tbca
uniprot id: A4QNK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
messages: cytoskeleton

8364:ropn1l
gene id: 8364:ropn1l
uniprot id: F6TZ91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ropporin family.
messages: flagellum

8364:chrnb4
gene id: 8364:chrnb4
uniprot id: A0A6I8RWF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:LOC100487899
gene id: 8364:LOC100487899
uniprot id: A0A8J1JF58
uniprot id: F7C448
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

8364:irgq
gene id: 8364:irgq
uniprot id: A0A6I8PNX0
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

8364:slc25a42
gene id: 8364:slc25a42
uniprot id: Q05AQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate.
messages: Mitochondrion inner membrane

8364:cyp2r1
gene id: 8364:cyp2r1
uniprot id: A0A803K6F7
uniprot id: A0A8J1JF51
uniprot id: A8KBH5
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:LOC100493016
gene id: 8364:LOC100493016
uniprot id: A0A8J1JAW3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC116409616
gene id: 8364:LOC116409616
uniprot id: A0A8J1JB00
names: Subcellular Location Annotation
messages: Membrane

8364:mlnr
gene id: 8364:mlnr
uniprot id: A0A8J0QLD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:gnb3
gene id: 8364:gnb3
uniprot id: Q5XGD8
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

8364:prop1
gene id: 8364:prop1
uniprot id: A0A6I8SZT2
names: Subcellular Location Annotation
messages: Nucleus

8364:mrps21
gene id: 8364:mrps21
uniprot id: Q28GG9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

8364:ern1
gene id: 8364:ern1
uniprot id: A0A8J1J021
names: Subcellular Location Annotation
messages: Membrane

8364:grik2
gene id: 8364:grik2
uniprot id: A0A6I8SEA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8364:LOC100496462
gene id: 8364:LOC100496462
uniprot id: A0A8J1JXV5
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

8364:gpr183.1
gene id: 8364:gpr183.1
uniprot id: A0A8J0T146
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:coq4
gene id: 8364:coq4
uniprot id: A0A803JFW9
uniprot id: Q28CM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ4 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least coq3, coq4, coq5, coq6, coq7 and coq9.
messages: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
messages: Mitochondrion inner membrane

8364:c5orf63
gene id: 8364:c5orf63
uniprot id: A0A8J0SKQ4
names: Similarity
messages: Belongs to the glutaredoxin family.

8364:LOC101730817
gene id: 8364:LOC101730817
uniprot id: Q6DK82
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:nr1h4
gene id: 8364:nr1h4
uniprot id: A0A6I8PNY1
uniprot id: A0A6I8QNB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

8364:hus1
gene id: 8364:hus1
uniprot id: Q6DF51
names: Similarity
messages: Belongs to the HUS1 family.

8364:paqr5
gene id: 8364:paqr5
uniprot id: A0A6I8REY1
uniprot id: A0A6I8SAE2
uniprot id: F6Y629
uniprot id: Q08CW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

8364:LOC100490165
gene id: 8364:LOC100490165
uniprot id: A0A8J0SZ58
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC101731623
gene id: 8364:LOC101731623
uniprot id: A0A803JIT8
names: Subcellular Location Annotation
messages: Membrane

8364:mrpl2
gene id: 8364:mrpl2
uniprot id: A4IIM1
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

8364:sox6
gene id: 8364:sox6
uniprot id: B1H349
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: sox5 and sox6 cooperatively bind with sox9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate sox9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube.

8364:ypel5
gene id: 8364:ypel5
uniprot id: Q640U2
names: Similarity
messages: Belongs to the yippee family.

8364:hap1
gene id: 8364:hap1
uniprot id: A0A7D9N0G6
uniprot id: A0A8J0SPK6
uniprot id: A0A8J0SZ39
uniprot id: A0A8J1IW23
uniprot id: A0A8J1IW26
uniprot id: B4F714
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

8364:ppm1a
gene id: 8364:ppm1a
uniprot id: A4IHV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

8364:sod3
gene id: 8364:sod3
uniprot id: F6QT27
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

8364:LOC116407638
gene id: 8364:LOC116407638
uniprot id: A0A8J1IWR7
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:art5
gene id: 8364:art5
uniprot id: Q28GI2
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

8364:slc35f6
gene id: 8364:slc35f6
uniprot id: A9UMH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLC35F solute transporter family.
messages: Interacts with SLC25A5.
messages: May play a role as a nucleotide-sugar transporter.
messages: Membrane
messages: Mitochondrion

8364:htr2b
gene id: 8364:htr2b
uniprot id: A0A7D9NMF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

8364:gpbp1
gene id: 8364:gpbp1
uniprot id: Q28FE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Functions as a GC-rich promoter-specific transactivating transcription factor.
messages: Nucleus

8364:alkbh5
gene id: 8364:alkbh5
uniprot id: Q66JG8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alkB family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (By similarity). Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity). Demethylation of m6A mRNA affects mRNA processing and export (By similarity).
messages: Monomer.
messages: Nucleus speckle

8364:rxfp1
gene id: 8364:rxfp1
uniprot id: A0A7D9NJN6
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:yod1
gene id: 8364:yod1
uniprot id: F7ECX1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin.

8364:vdac2
gene id: 8364:vdac2
uniprot id: Q07G51
names: Similarity
messages: Belongs to the eukaryotic mitochondrial porin family.

8364:rpn2
gene id: 8364:rpn2
uniprot id: A0A6I8RW67
uniprot id: Q5I083
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

8364:slc30a4
gene id: 8364:slc30a4
uniprot id: A1L1E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

8364:gabrb3
gene id: 8364:gabrb3
uniprot id: A0A803KHB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:zc3hc1
gene id: 8364:zc3hc1
uniprot id: Q5M8S7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus
messages: Probable component of a SCF(NIPA) E3 complex.
messages: Probable component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1).

8364:nit2
gene id: 8364:nit2
uniprot id: Q28IE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.
messages: Cytoplasm
messages: Has omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively.
messages: Homodimer.

8364:dst
gene id: 8364:dst
uniprot id: A0A8J0SPC7
uniprot id: A0A8J0T383
uniprot id: A0A8J0T4G3
uniprot id: A0A8J1JLZ2
uniprot id: A0A8J1JLZ5
uniprot id: A0A8J1JLZ7
uniprot id: A0A8J1JLZ8
uniprot id: A0A8J1JM01
uniprot id: A0A8J1JM02
uniprot id: A0A8J1JM03
uniprot id: A0A8J1JM06
uniprot id: A0A8J1JM07
uniprot id: A0A8J1JM08
uniprot id: A0A8J1JM11
uniprot id: A0A8J1JM13
uniprot id: A0A8J1JM14
uniprot id: A0A8J1JM17
uniprot id: A0A8J1JM18
uniprot id: A0A8J1JPE1
uniprot id: A0A8J1JPE6
uniprot id: A0A8J1JPF1
uniprot id: A0A8J1JPF6
uniprot id: A0A8J1JPG4
uniprot id: A0A8J1JQN0
uniprot id: A0A8J1JQN6
uniprot id: A0A8J1JQP1
uniprot id: A0A8J1JQP7
uniprot id: A0A8J1JQQ3
names: Subcellular Location Annotation
messages: cytoskeleton

8364:pnkd
gene id: 8364:pnkd
uniprot id: A0A803J4I4
uniprot id: A8WGF1
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

8364:cpne4
gene id: 8364:cpne4
uniprot id: A0A6I8RH77
names: Similarity
messages: Belongs to the copine family.

8364:cenpa
gene id: 8364:cenpa
uniprot id: Q28I31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H3 family.
messages: Component of centromeric nucleosomes, where DNA is wrapped around a histone octamer core. The octamer contains two molecules each of H2A, H2B, CENPA and H4 assembled in one CENPA-H4 heterotetramer and two H2A-H2B heterodimers. CENPA modulates the DNA-binding characteristics of nucleosomes so that protruding DNA ends have higher flexibility than in nucleosomes containing conventional histone H3.
messages: Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis.
messages: Nucleus
messages: centromere

8364:lrrfip1
gene id: 8364:lrrfip1
uniprot id: A0A6I8QQT6
uniprot id: A0A8J0SP11
uniprot id: A0A8J0SP16
uniprot id: A0A8J0SP21
uniprot id: A0A8J0SP26
uniprot id: A0A8J0SP31
uniprot id: A0A8J0SW32
uniprot id: A0A8J0SW37
uniprot id: A0A8J0SW42
uniprot id: A0A8J0SW47
uniprot id: A0A8J0SW52
uniprot id: A0A8J0SXX3
uniprot id: A0A8J0SXX8
uniprot id: A0A8J0SXY2
uniprot id: A0A8J0SXY7
uniprot id: A0A8J0SXZ1
uniprot id: A0A8J0SYK3
uniprot id: A0A8J0SYK7
uniprot id: A0A8J0SYL1
uniprot id: A0A8J0SYL6
uniprot id: A0A8J0SYM1
uniprot id: A0A8J0SZ74
uniprot id: A0A8J0SZ79
uniprot id: A0A8J0SZ84
uniprot id: A0A8J0SZ88
uniprot id: A0A8J0SZ95
uniprot id: A0A8J1IU70
uniprot id: A0A8J1IU73
uniprot id: A0A8J1IU84
uniprot id: A0A8J1IXB7
names: Similarity
messages: Belongs to the LRRFIP family.

8364:cda
gene id: 8364:cda
uniprot id: Q28II3
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

8364:LOC101730384
gene id: 8364:LOC101730384
uniprot id: A0A8J1JRF8
names: Subcellular Location Annotation
messages: Membrane

8364:wdfy2
gene id: 8364:wdfy2
uniprot id: A0A6I8QPN5
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

8364:ramp1
gene id: 8364:ramp1
uniprot id: Q0IIU7
names: Similarity
messages: Belongs to the RAMP family.

8364:crtac1
gene id: 8364:crtac1
uniprot id: A0A8J0SSQ5
uniprot id: A0A8J1JT24
uniprot id: Q0V9M0
names: Caution
names: Subcellular Location Annotation
messages: It is uncertain whether Met-1 or Met-2 is the initiator.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:insig2
gene id: 8364:insig2
uniprot id: Q5U4Q2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the INSIG family.
messages: Binds oxysterols in a pocket within their transmembrane domains and interacts with scap via transmembrane domains 3 and 4.
messages: Endoplasmic reticulum membrane
messages: Interacts with scap; interaction is direct and only takes place in the presence of sterols; it prevents interaction between scap and the coat protein complex II (COPII). Associates with the SCAP-SREBP complex; association is mediated via its interaction with scap and only takes place in the presence of sterols.
messages: Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of scap and degradation of hmgcr. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs). Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with scap and retention of the SCAP-SREBP complex in the endoplasmic reticulum. In presence of oxysterol, interacts with scap, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing scap from escorting SREBPs to the Golgi. Sterol deprivation reduce oxysterol-binding, disrupting the interaction between insig2 and scap, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBPs. Also regulates cholesterol synthesis by regulating degradation of hmgcr.
messages: The KxHxx motif mediates association with the coatomer complex.

8364:meltf
gene id: 8364:meltf
uniprot id: A0A8J0QP26
names: Similarity
messages: Belongs to the transferrin family.

8364:astl2b
gene id: 8364:astl2b
uniprot id: A0A8J0SCT8
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC116412040
gene id: 8364:LOC116412040
uniprot id: A0A8J1JTN7
uniprot id: A0A8J1JXH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8364:LOC100491805
gene id: 8364:LOC100491805
uniprot id: A0A6I8PZA9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:pdlim3
gene id: 8364:pdlim3
uniprot id: A0A6I8QUD5
uniprot id: A0A803KGJ0
uniprot id: F7BM59
names: Subcellular Location Annotation
messages: Z line

8364:serp2
gene id: 8364:serp2
uniprot id: Q0V9K8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane

8364:nfat5
gene id: 8364:nfat5
uniprot id: A0A6I8Q6G9
uniprot id: A0A6I8R1E5
uniprot id: A0A8J0QYC9
uniprot id: A0A8J0QYD4
uniprot id: A0A8J0R2K1
uniprot id: A0A8J0SK28
uniprot id: F6VKJ6
names: Subcellular Location Annotation
messages: Nucleus

8364:c6.2
gene id: 8364:c6.2
uniprot id: Q6DEX1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:atp23
gene id: 8364:atp23
uniprot id: A0A8J0T2B5
uniprot id: Q5BKJ4
names: Similarity
messages: Belongs to the peptidase M76 family.

8364:gal.2
gene id: 8364:gal.2
uniprot id: A0A6I8RIF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galanin family.
messages: Secreted

8364:dpy19l3
gene id: 8364:dpy19l3
uniprot id: A0A6I8PZW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

8364:fgg
gene id: 8364:fgg
uniprot id: F6SPR7
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

8364:LOC100497764
gene id: 8364:LOC100497764
uniprot id: A0A8J0QY22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:ubr4
gene id: 8364:ubr4
uniprot id: A0A803JFS8
uniprot id: A0A8J1JTV9
uniprot id: A0A8J1JTW2
uniprot id: A0A8J1JTW3
uniprot id: A0A8J1JTW5
uniprot id: A0A8J1JTW6
uniprot id: A0A8J1JTW8
uniprot id: A0A8J1JTX3
uniprot id: A0A8J1JTX4
uniprot id: A0A8J1JWC3
uniprot id: A0A8J1JWD0
uniprot id: A0A8J1JWD5
uniprot id: A0A8J1JXQ1
uniprot id: A0A8J1JXQ5
uniprot id: A0A8J1JXR1
names: Similarity
messages: Belongs to the UBR4 family.

8364:LOC100494536
gene id: 8364:LOC100494536
uniprot id: A0A8J1IYZ0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8364:tmem242
gene id: 8364:tmem242
uniprot id: B7ZTD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM242 family.
messages: Membrane

8364:LOC100379837
gene id: 8364:LOC100379837
uniprot id: A0A6I8QHZ9
uniprot id: A0A8J0QXA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIEAP family.
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion outer membrane

8364:vgll4
gene id: 8364:vgll4
uniprot id: A0A803JEH7
uniprot id: A0A8J1JDY0
uniprot id: Q0IHR7
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

8364:LOC116412276
gene id: 8364:LOC116412276
uniprot id: A0A803JJ42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:hjv
gene id: 8364:hjv
uniprot id: A0A6I8RG06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

8364:pex1
gene id: 8364:pex1
uniprot id: A0A6I8Q6G4
uniprot id: F6SHU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: cytosol

8364:siah3
gene id: 8364:siah3
uniprot id: A0A6I8RL86
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

8364:p2rx5
gene id: 8364:p2rx5
uniprot id: A0A6I8SK99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

8364:dupd1
gene id: 8364:dupd1
uniprot id: A0A6I8RVL6
uniprot id: A0A803JET8
uniprot id: A4IHU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Cytoplasm
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of AMPK and MAPK1/2 signaling pathways (By similarity).
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.
messages: Nucleus

8364:nupr1
gene id: 8364:nupr1
uniprot id: A0A803JUR3
names: Similarity
messages: Belongs to the NUPR family.

8364:phb
gene id: 8364:phb
uniprot id: Q6P850
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

8364:btg2
gene id: 8364:btg2
uniprot id: Q640A4
names: Similarity
messages: Belongs to the BTG family.

8364:fzd8
gene id: 8364:fzd8
uniprot id: A0A803J9G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Membrane

8364:fignl1
gene id: 8364:fignl1
uniprot id: A4IHT0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Hexamer.
messages: May be involved in DNA double-strand break (DBS) repair via homologous recombination (HR). May regulate osteoblast proliferation and differentiation (By similarity).
messages: Nucleus
messages: The N-terminus is necessary for its recruitment to DNA damage sites.
messages: perinuclear region

8364:vps26b
gene id: 8364:vps26b
uniprot id: Q5BKM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity).
messages: Belongs to the VPS26 family.
messages: Component of the heterotrimeric retromer cargo-selective complex (CSC) which is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants (By similarity).
messages: Cytoplasm
messages: Endosome
messages: Membrane

8364:dcn
gene id: 8364:dcn
uniprot id: A4IIC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.
messages: May affect the rate of fibrils formation.
messages: extracellular matrix

8364:LOC116407803
gene id: 8364:LOC116407803
uniprot id: A0A8J1IVR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

8364:sorcs1
gene id: 8364:sorcs1
uniprot id: A0A8J1JUL6
names: Similarity
messages: Belongs to the VPS10-related sortilin family. SORCS subfamily.

8364:hey1
gene id: 8364:hey1
uniprot id: Q66KK8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HEY family.
messages: Downstream effector of Notch signaling. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Acts as a suppressor of neurogenesis by antagonizing proneural gene function. Functions during floorplate development. Plays a role in pronephros formation in the inhibition of distal tubule and duct cell fates and the promotion of glomus and proximal tubule formation (By similarity).
messages: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA in the form of homodimer or more strongly as a heterodimer with hes1/hairy1 or hes4/hairy2b. Also weakly interacts with the bHLH proteins hes2, neurod1 and neurod4/ath3. Interacts (via Orange domain) with ccdc89/boip (via C-terminus) (By similarity).
messages: Nucleus
messages: The C-terminal YRPW motif is not required for transcriptional repressor activity and is unable to recruit groucho.
messages: The Orange domain, downstream sequence and the bHLH are required for efficient heterodimerization with hes/hairy proteins, and for transcriptional repressor activity.

8364:LOC116410323
gene id: 8364:LOC116410323
uniprot id: A0A8J1JEY0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:rida
gene id: 8364:rida
uniprot id: Q28GJ3
names: Function
names: Similarity
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.

8364:runx3
gene id: 8364:runx3
uniprot id: A0A8J0QSL0
names: Subcellular Location Annotation
messages: Nucleus

8364:trpc4
gene id: 8364:trpc4
uniprot id: F6V6Z5
names: Subcellular Location Annotation
messages: Membrane

8364:nfe2l3
gene id: 8364:nfe2l3
uniprot id: A0A6I8SVT3
uniprot id: F6TA02
names: Similarity
messages: Belongs to the bZIP family. CNC subfamily.

8364:LOC105948380
gene id: 8364:LOC105948380
uniprot id: A0A8J1IYV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:rarb
gene id: 8364:rarb
uniprot id: A0A6I8R4R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

8364:btg1
gene id: 8364:btg1
uniprot id: Q6P7M4
names: Similarity
messages: Belongs to the BTG family.

8364:LOC100489456
gene id: 8364:LOC100489456
uniprot id: F6TLZ9
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:atp8b4
gene id: 8364:atp8b4
uniprot id: A0A6I8SMD5
uniprot id: A0A8J0SSG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

8364:mppe1
gene id: 8364:mppe1
uniprot id: A0A6I8QT90
uniprot id: A0A8J1JQX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallophosphoesterase superfamily. MPPE1 family.
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.
messages: cis-Golgi network membrane

8364:ppil3
gene id: 8364:ppil3
uniprot id: Q6DIK1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

8364:ass1
gene id: 8364:ass1
uniprot id: Q5M8Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family.
messages: Homotetramer.
messages: One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.
messages: cytosol

8364:celf3
gene id: 8364:celf3
uniprot id: A0A8J1IP73
uniprot id: A8KBC9
uniprot id: Q28HL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Nucleus

8364:snx30
gene id: 8364:snx30
uniprot id: A8E4U2
uniprot id: Q28E02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Involved in the regulation of endocytosis and in several stages of intracellular trafficking. Together with snx4, involved in autophagosome assembly.

8364:LOC100493950
gene id: 8364:LOC100493950
uniprot id: A0A8J0QTD8
names: Similarity
messages: Belongs to the cystatin family.

8364:cox10
gene id: 8364:cox10
uniprot id: B0BMH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiA prenyltransferase family.
messages: Converts protoheme IX and farnesyl diphosphate to heme O.
messages: Membrane
messages: Mitochondrion membrane

8364:LOC100498119
gene id: 8364:LOC100498119
uniprot id: A0A6I8PV16
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:nfkb2
gene id: 8364:nfkb2
uniprot id: A0A8J0SS56
uniprot id: A0A8J0STJ0
uniprot id: Q6DF61
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:nt5c3b
gene id: 8364:nt5c3b
uniprot id: F7D9T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

8364:cyp3a4.2
gene id: 8364:cyp3a4.2
uniprot id: A0A6I8Q487
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:LOC100490967
gene id: 8364:LOC100490967
uniprot id: A0A6I8QB71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100496053
gene id: 8364:LOC100496053
uniprot id: A0A8J0SG84
uniprot id: F7E5W4
names: Subcellular Location Annotation
messages: Membrane

8364:dnal4
gene id: 8364:dnal4
uniprot id: Q6DIF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

8364:ints14
gene id: 8364:ints14
uniprot id: Q66KD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INTS14 family.
messages: Nucleus
messages: Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

8364:rbm6
gene id: 8364:rbm6
uniprot id: A0A803JEM6
uniprot id: Q6DEQ5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Component of the 40S small ribosomal subunit.

8364:yrdc
gene id: 8364:yrdc
uniprot id: Q5FVA3
names: Similarity
messages: Belongs to the SUA5 family.

8364:krt12.1
gene id: 8364:krt12.1
uniprot id: A0A803JWW7
names: Similarity
messages: Belongs to the intermediate filament family.

8364:impdh2
gene id: 8364:impdh2
uniprot id: A0A5S6LFP1
uniprot id: A0A6I8QIY7
uniprot id: Q66JD5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

8364:katnb1
gene id: 8364:katnb1
uniprot id: Q6NVM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat KATNB1 family.
messages: Cytoplasm
messages: Interacts with katna1. This interaction enhances the microtubule binding and severing activity of katna1 and also targets this activity to the centrosome.
messages: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

8364:mrap
gene id: 8364:mrap
uniprot id: A0A8J0QRQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:LOC100487218
gene id: 8364:LOC100487218
uniprot id: A0A8J1ITD8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inflammasome

8364:cnp
gene id: 8364:cnp
uniprot id: A0A6I8RTA0
uniprot id: A0A8J0QVM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2H phosphoesterase superfamily. CNPase family.
messages: Exists as monomers and homodimers.
messages: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
messages: Melanosome
messages: Membrane

8364:LOC100496494
gene id: 8364:LOC100496494
uniprot id: A0A8J0SZP5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:eif3j
gene id: 8364:eif3j
uniprot id: A0A8J0QGZ9
uniprot id: Q5I0B5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit J family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

8364:midn
gene id: 8364:midn
uniprot id: A0A8J0SLZ0
uniprot id: B5DDY7
uniprot id: Q5EB28
names: Function
names: Subcellular Location Annotation
messages: Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.
messages: Nucleus
messages: cytosol
messages: nucleolus

8364:smarcal1
gene id: 8364:smarcal1
uniprot id: A0A8J1ISP2
uniprot id: Q0P4U8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA (By similarity).
messages: Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.
messages: Nucleus

8364:lmo4.1
gene id: 8364:lmo4.1
uniprot id: Q6DJ06
names: Function
messages: Acts as a positive cofactor of GATA transcription factors to establish the identity of the ventral mesoderm during gastrulation. Down-regulation in the dorsal mesoderm is necessary for the proper formation of this territory since, when present, lmo4 may bind ldb1 and restrict the availability of this cofactor for Spemman organizer transcription factors. At neurula stages, suppresses primary neuron differentiation and modulates gene expression at the Isthmic Organizer of the midbrain-hindbrain boundary (By similarity).

8364:aldh1b1
gene id: 8364:aldh1b1
uniprot id: F7DQF8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

8364:MGC89178
gene id: 8364:MGC89178
uniprot id: A0A803KJI2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:rad50
gene id: 8364:rad50
uniprot id: A0A8J0SAB8
names: Similarity
messages: Belongs to the SMC family. RAD50 subfamily.

8364:sult1c2
gene id: 8364:sult1c2
uniprot id: F7CNN0
uniprot id: Q6DJ68
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8364:ptpn6
gene id: 8364:ptpn6
uniprot id: A0A803KIW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

8364:admp2
gene id: 8364:admp2
uniprot id: A0A6I8QWS3
names: Similarity
messages: Belongs to the TGF-beta family.

8364:nabp2
gene id: 8364:nabp2
uniprot id: Q66K94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SOSS-B family. SOSS-B1 subfamily.
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) (By similarity).
messages: Component of the SOSS complex, composed of soss-b (soss-b1/nabp2 or soss-b2/nabp1), soss-a/ints3 and soss-c/inip. SOSS complexes containing soss-b1/nabp2 are more abundant than complexes containing soss-b2/nabp1 (By similarity).
messages: Nucleus

8364:mgat5b
gene id: 8364:mgat5b
uniprot id: A0A8J0R5E2
uniprot id: F6RM62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 18 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:cd34
gene id: 8364:cd34
uniprot id: A0A8J0QUJ9
names: Subcellular Location Annotation
messages: Membrane

8364:gdpgp1
gene id: 8364:gdpgp1
uniprot id: Q0V9F1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDPGP1 family.
messages: Cytoplasm
messages: Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.
messages: The ortholog in A.thaliana catalyzes the first reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants.

8364:sh3gl1
gene id: 8364:sh3gl1
uniprot id: Q6P836
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

8364:ephb3
gene id: 8364:ephb3
uniprot id: A0A6I8RKK6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:chst10
gene id: 8364:chst10
uniprot id: A0A8J0QZA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:tbx4
gene id: 8364:tbx4
uniprot id: A0A6I8QXA7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8364:aldh8a1
gene id: 8364:aldh8a1
uniprot id: F6UH88
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

8364:mex3d
gene id: 8364:mex3d
uniprot id: B0JZY2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:nrde2
gene id: 8364:nrde2
uniprot id: A0A6I8PV13
uniprot id: A0A8J1IPN1
uniprot id: Q08D48
names: Similarity
messages: Belongs to the NRDE2 family.

8364:LOC100497082
gene id: 8364:LOC100497082
uniprot id: Q28J31
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:slc25a53
gene id: 8364:slc25a53
uniprot id: F6W124
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8364:s100z
gene id: 8364:s100z
uniprot id: F7ELU6
names: Similarity
messages: Belongs to the S-100 family.

8364:sfr1
gene id: 8364:sfr1
uniprot id: A0A8J1JUK9
uniprot id: F6YR00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFR1/MEI5 family.
messages: Nucleus

8364:zw10
gene id: 8364:zw10
uniprot id: B1H3L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZW10 family.
messages: kinetochore

8364:tmem8b
gene id: 8364:tmem8b
uniprot id: A0A8J1IZ58
uniprot id: F6SHJ7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:cops4
gene id: 8364:cops4
uniprot id: Q28J21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN4 family.
messages: Nucleus
messages: Vesicle
messages: synaptic vesicle

8364:shbg
gene id: 8364:shbg
uniprot id: A0A803JL43
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC116412232
gene id: 8364:LOC116412232
uniprot id: A0A8J1JZB4
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8364:med24
gene id: 8364:med24
uniprot id: A0A6I8SGB0
uniprot id: A0A8J0SDT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 24 family.
messages: Nucleus

8364:grb10
gene id: 8364:grb10
uniprot id: A0A6I8QDA8
uniprot id: A0A8J1JMI3
uniprot id: B2GUA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

8364:maf
gene id: 8364:maf
uniprot id: Q0V9K1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional activator or repressor.
messages: Belongs to the bZIP family. Maf subfamily.
messages: Expressed in the presumptive lens ectoderm at stage 24. Expressed in the pronephros from stage 28 onwards. Expressed in the forming tubules but also in the glomus of the pronephros from stage 33. Expressed in cells of the optic vesicle in a dorso-temporal location and in cells showing the expected dorsal location of Rohon-Beard neurons in the neural tube at stage 35.
messages: Homodimer or heterodimer. Binds DNA as a homodimer or a heterodimer (By similarity).
messages: Nucleus

8364:dusp10
gene id: 8364:dusp10
uniprot id: A0A803K4C7
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

8364:LOC116412237
gene id: 8364:LOC116412237
uniprot id: A0A8J1JZE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

8364:LOC116408400
gene id: 8364:LOC116408400
uniprot id: A0A8J1J1Z8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:paqr3
gene id: 8364:paqr3
uniprot id: A0A8J0PH06
uniprot id: F6XNG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

8364:phox2b
gene id: 8364:phox2b
uniprot id: B1WBH8
uniprot id: F6ZB02
names: Subcellular Location Annotation
messages: Nucleus

8364:tmem45b
gene id: 8364:tmem45b
uniprot id: Q5XGD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

8364:ap2s1
gene id: 8364:ap2s1
uniprot id: Q28GD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cell membrane
messages: coated pit

8364:rps9
gene id: 8364:rps9
uniprot id: Q6DFN8
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

8364:hepacam
gene id: 8364:hepacam
uniprot id: F7A8J7
names: Similarity
messages: Belongs to the UPF0524 family.

8364:cemip2
gene id: 8364:cemip2
uniprot id: F7BV94
names: Similarity
messages: Belongs to the CEMIP family.

8364:dgat2l6
gene id: 8364:dgat2l6
uniprot id: F6TLW5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:acod1
gene id: 8364:acod1
uniprot id: A0A6I8PZZ7
uniprot id: A0A8J1J4Z5
names: Similarity
messages: Belongs to the PrpD family.

8364:mkx
gene id: 8364:mkx
uniprot id: A0A803KDG5
uniprot id: A0A8J1JTM0
names: Subcellular Location Annotation
messages: Nucleus

8364:nipal2
gene id: 8364:nipal2
uniprot id: A0A6I8SCX4
uniprot id: Q6DEW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

8364:rpp14
gene id: 8364:rpp14
uniprot id: Q07G50
uniprot id: Q0IIW5
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

8364:gng3
gene id: 8364:gng3
uniprot id: A4IGZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8364:LOC101734517
gene id: 8364:LOC101734517
uniprot id: A0A8J0QWN6
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:LOC116408367
gene id: 8364:LOC116408367
uniprot id: A0A8J1J1V8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:psen2
gene id: 8364:psen2
uniprot id: F7C949
uniprot id: Q28HZ1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: The PAL motif is required for normal active site conformation.

8364:LOC116411561
gene id: 8364:LOC116411561
uniprot id: A0A8J1JPT8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC100492280
gene id: 8364:LOC100492280
uniprot id: A0A6I8RHS2
uniprot id: A0A8J0QNM0
uniprot id: A0A8J1JTY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

8364:kctd10
gene id: 8364:kctd10
uniprot id: A0A8J0PHX9
uniprot id: F6U3U6
uniprot id: Q28HW7
names: Similarity
messages: Belongs to the BACURD family.

8364:scnn1g
gene id: 8364:scnn1g
uniprot id: A0A6I8S1S4
uniprot id: F6W3N3
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Membrane
messages: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.

8364:abcb5
gene id: 8364:abcb5
uniprot id: A0A8J1JMQ2
uniprot id: F6XR15
uniprot id: Q6P3N4
names: Subcellular Location Annotation
messages: Membrane

8364:slc1a5
gene id: 8364:slc1a5
uniprot id: F7C3I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

8364:or52m1
gene id: 8364:or52m1
uniprot id: A0A8J1J6F7
names: Subcellular Location Annotation
messages: Membrane

8364:spata5l1
gene id: 8364:spata5l1
uniprot id: Q0VA52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent chaperone, which plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles.
messages: Belongs to the AAA ATPase family. AFG2 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: spindle

8364:sh3bp5l
gene id: 8364:sh3bp5l
uniprot id: A4IH82
names: Function
names: Similarity
messages: Belongs to the SH3BP5 family.
messages: Functions as guanine nucleotide exchange factor (GEF) for rab11a.

8364:LOC116407060
gene id: 8364:LOC116407060
uniprot id: A0A803JMX7
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

8364:LOC100495907
gene id: 8364:LOC100495907
uniprot id: A0A8J0T6G2
uniprot id: F6UXB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8364:rprd2
gene id: 8364:rprd2
uniprot id: A0A6I8PKD2
uniprot id: A0A803KD13
names: Similarity
messages: Belongs to the UPF0400 (RTT103) family.

8364:eral1
gene id: 8364:eral1
uniprot id: F6WY27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.

8364:mrps16
gene id: 8364:mrps16
uniprot id: Q28GK1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

8364:LOC100494476
gene id: 8364:LOC100494476
uniprot id: A0A8J0T4D4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:LOC116412269
gene id: 8364:LOC116412269
uniprot id: A0A8J1JVS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

8364:atp6v0e1
gene id: 8364:atp6v0e1
uniprot id: B4F6J0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

8364:hsd17b4
gene id: 8364:hsd17b4
uniprot id: A0A803KGH0
uniprot id: F6ZBK6
names: Subcellular Location Annotation
messages: Peroxisome

8364:chmp4c
gene id: 8364:chmp4c
uniprot id: A0A7D9NKB5
names: Similarity
messages: Belongs to the SNF7 family.

8364:LOC116406589
gene id: 8364:LOC116406589
uniprot id: A0A8J1IML1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:pias3
gene id: 8364:pias3
uniprot id: A0A8J1IKV4
uniprot id: B0JZD8
uniprot id: F6ZBV4
names: Similarity
messages: Belongs to the PIAS family.

8364:ppa2
gene id: 8364:ppa2
uniprot id: Q5I093
names: Similarity
messages: Belongs to the PPase family.

8364:LOC105946653
gene id: 8364:LOC105946653
uniprot id: A0A8J0S8Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC116406833
gene id: 8364:LOC116406833
uniprot id: A0A8J1IPX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:znf711
gene id: 8364:znf711
uniprot id: A0A8J0QFH4
uniprot id: A0A8J1K1Y2
uniprot id: F7B6U1
names: Subcellular Location Annotation
messages: Nucleus

8364:chrm5
gene id: 8364:chrm5
uniprot id: A0A6I8PJ30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

8364:cep120
gene id: 8364:cep120
uniprot id: B1H2P5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP120 family.
messages: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome.
messages: centrosome

8364:podxl
gene id: 8364:podxl
uniprot id: A0A6I8SLR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the podocalyxin family.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: filopodium
messages: lamellipodium
messages: microvillus
messages: ruffle

8364:LOC116412338
gene id: 8364:LOC116412338
uniprot id: A0A8J1K0V0
names: Subcellular Location Annotation
messages: Membrane

8364:lmx1b.2
gene id: 8364:lmx1b.2
uniprot id: F7CT16
names: Subcellular Location Annotation
messages: Nucleus

8364:tm4sf19
gene id: 8364:tm4sf19
uniprot id: A0A6I8Q2P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

8364:fam122c
gene id: 8364:fam122c
uniprot id: A0A8J0SKI8
uniprot id: Q6P372
names: Similarity
messages: Belongs to the FAM122 family.

8364:ckb
gene id: 8364:ckb
uniprot id: A0A6I8RD78
uniprot id: Q28GS7
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

8364:flt4
gene id: 8364:flt4
uniprot id: A0A6I8RMQ8
uniprot id: A0A8J0SJK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

8364:LOC100488328
gene id: 8364:LOC100488328
uniprot id: A0A8J1J0E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

8364:LOC101732116
gene id: 8364:LOC101732116
uniprot id: F7AMW9
names: Similarity
messages: Belongs to the cyclin family.

8364:trappc1
gene id: 8364:trappc1
uniprot id: Q642T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

8364:pigw
gene id: 8364:pigw
uniprot id: F6QUR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGW family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.

8364:LOC100496805
gene id: 8364:LOC100496805
uniprot id: A0A8J1JBW9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC101732908
gene id: 8364:LOC101732908
uniprot id: B0JZ06
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:peli2
gene id: 8364:peli2
uniprot id: Q6P4Y5
names: Similarity
messages: Belongs to the pellino family.

8364:smim18
gene id: 8364:smim18
uniprot id: A0A803KC77
names: Subcellular Location Annotation
messages: Membrane

8364:mustn1
gene id: 8364:mustn1
uniprot id: A8E5X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MUSTANG family.
messages: Nucleus

8364:cldn12
gene id: 8364:cldn12
uniprot id: A0A803K7U4
uniprot id: Q5FVA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Membrane
messages: tight junction

8364:LOC116412140
gene id: 8364:LOC116412140
uniprot id: A0A8J1JUS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100489771
gene id: 8364:LOC100489771
uniprot id: A0A8J1ITT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

8364:crygdl.4
gene id: 8364:crygdl.4
uniprot id: A0A8J0QM14
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:f13a1
gene id: 8364:f13a1
uniprot id: A0A6I8QSC0
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

8364:nup98
gene id: 8364:nup98
uniprot id: A0A8J1J4F0
uniprot id: J7I6Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin GLFG family.
messages: Nucleus membrane
messages: nuclear pore complex

8364:trap1
gene id: 8364:trap1
uniprot id: A0A6I8RDG5
names: Similarity
messages: Belongs to the heat shock protein 90 family.

8364:myh3
gene id: 8364:myh3
uniprot id: Q6DIX8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:nup35
gene id: 8364:nup35
uniprot id: A0A8J0SVG9
uniprot id: A0A8J0SYK0
uniprot id: F6RNJ8
uniprot id: Q66IJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nup35 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors (By similarity).
messages: nuclear pore complex

8364:smad4.1
gene id: 8364:smad4.1
uniprot id: A0A8J0QJT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

8364:agap3
gene id: 8364:agap3
uniprot id: A0A803JM32
uniprot id: A0A803KFT7
uniprot id: A0A8J1JSD9
names: Similarity
messages: Belongs to the centaurin gamma-like family.

8364:LOC100486806
gene id: 8364:LOC100486806
uniprot id: A0A803J4L4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:cpa3
gene id: 8364:cpa3
uniprot id: A0A6I8SCX3
names: Similarity
messages: Belongs to the peptidase M14 family.

8364:tbx21
gene id: 8364:tbx21
uniprot id: A0A6I8PUN9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8364:vps45
gene id: 8364:vps45
uniprot id: Q0D2D9
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

8364:LOC116407955
gene id: 8364:LOC116407955
uniprot id: A0A8J1IZS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: nucleoplasm

8364:capn1
gene id: 8364:capn1
uniprot id: Q66IH0
names: Similarity
messages: Belongs to the peptidase C2 family.

8364:ttc38
gene id: 8364:ttc38
uniprot id: A0A1B8Y383
uniprot id: Q6DIV2
names: Similarity
messages: Belongs to the TTC38 family.

8364:mdh2
gene id: 8364:mdh2
uniprot id: F6T7F0
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

8364:mpdu1
gene id: 8364:mpdu1
uniprot id: Q28FR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPDU1 (TC 2.A.43.3) family.
messages: Membrane

8364:wnt11
gene id: 8364:wnt11
uniprot id: B2GUT4
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Glycosylation is required for protein secretion.
messages: Ligand for members of the frizzled family of seven transmembrane receptors (By similarity). Shares much functionality with wnt11b. Signals through a non-canonical Wnt pathway to activate Jun-N-terminal kinase (JNK) to regulate gastrulation movements. Acts in a non-cell-autonomous manner to control neural crest migration, probably acting as an extracellular signal from surrounding tissue, but is not required for neural crest induction. Acts redundantly with wnt11b during pronephros induction. Regulates cardiac morphogenesis through the activation of JNK, but is not required for cardiac differentiation. Essential for dorsal fin development; required for an epithelial to mesenchymal transformation event prior to migration of cells into the fin, and ultimately for maintenance of fin structure. Mediates dorsal fin development through a non-canonical pathway mediated by Ca(2+) (By similarity).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Xenopus and other lower vertebrates contain duplicated wnt11 genes (wnt11 and wnt11b) resulting from an ancient gene duplication event, but the second copy has since been lost in mammals.
messages: extracellular matrix

8364:kcnj3
gene id: 8364:kcnj3
uniprot id: F6R882
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

8364:xpr1
gene id: 8364:xpr1
uniprot id: Q28CY9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYG1 (TC 2.A.94) family.
messages: Cell membrane
messages: Plays a role in phosphate homeostasis. Mediates phosphate export from the cell. Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules.
messages: The SPX domain has high affinity for inositol polyphosphates, such as myo-inositol hexakisphosphate and 5-diphospho-myo-inositol pentakisphosphate (5-InsP7). Its affinity for inorganic phosphate is tow to three orders of magnitude lower.

8364:serpinc1
gene id: 8364:serpinc1
uniprot id: Q66IF8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the serpin family.
messages: Forms protease inhibiting heterodimer with TMPRSS7.
messages: extracellular space

8364:shroom1
gene id: 8364:shroom1
uniprot id: F7B3H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

8364:metap1
gene id: 8364:metap1
uniprot id: A0A8J0T1U8
uniprot id: Q5I0A0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the 60S ribosomal subunit of the 80S translational complex.
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm

8364:selenoi
gene id: 8364:selenoi
uniprot id: A0A8J0PCX5
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

8364:dbt
gene id: 8364:dbt
uniprot id: Q28E15
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

8364:pde11a
gene id: 8364:pde11a
uniprot id: A0A8J1IT46
uniprot id: F7EJP6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8364:LOC116409644
gene id: 8364:LOC116409644
uniprot id: A0A8J1J8N8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:LOC100495184
gene id: 8364:LOC100495184
uniprot id: B5DDY3
uniprot id: Q28DR4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by pak2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

8364:ankh
gene id: 8364:ankh
uniprot id: A0A6I8T1U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKH family.
messages: Membrane
messages: Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.

8364:fez2
gene id: 8364:fez2
uniprot id: A0A6I8PS57
uniprot id: Q28GI7
names: Similarity
messages: Belongs to the zygin family.

8364:rpe
gene id: 8364:rpe
uniprot id: F7BWX1
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

8364:LOC101733847
gene id: 8364:LOC101733847
uniprot id: A0A1B8Y741
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:atp7a
gene id: 8364:atp7a
uniprot id: A0A6I8QF43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane
messages: trans-Golgi network membrane

8364:tmem138
gene id: 8364:tmem138
uniprot id: Q66JC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM138 family.
messages: Required for ciliogenesis.
messages: Vacuole membrane
messages: cilium

8364:retreg3
gene id: 8364:retreg3
uniprot id: A0A8J0T474
uniprot id: A0A8J1IWI2
uniprot id: F7CTN8
uniprot id: Q0P4Z1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RETREG family.
messages: Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress. When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins. Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes.
messages: Endoplasmic reticulum membrane
messages: Interacts with ATG8 family modifier proteins.
messages: Membrane
messages: The LIR motif interacts with ATG8 family proteins.

8364:manba
gene id: 8364:manba
uniprot id: F7EIP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
messages: Lysosome
messages: Monomer.

8364:ptgis
gene id: 8364:ptgis
uniprot id: A0A6I8RA65
uniprot id: A0A8J0R5J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

8364:sgk3
gene id: 8364:sgk3
uniprot id: A0A6I8Q7I4
uniprot id: A0A8J0R030
uniprot id: A0A8J0R284
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

8364:gpi
gene id: 8364:gpi
uniprot id: F6ZHL4
names: Similarity
messages: Belongs to the GPI family.

8364:gdf1
gene id: 8364:gdf1
uniprot id: F6UHX6
names: Similarity
messages: Belongs to the TGF-beta family.

8364:tmem70
gene id: 8364:tmem70
uniprot id: A0A6I8Q349
names: Similarity
messages: Belongs to the TMEM70 family.

8364:rbm15
gene id: 8364:rbm15
uniprot id: F6QUY1
names: Similarity
messages: Belongs to the RRM Spen family.

8364:tom1l1
gene id: 8364:tom1l1
uniprot id: A0A8J0QEJ1
uniprot id: A0A8J0SWR4
uniprot id: F6PP54
names: Similarity
messages: Belongs to the TOM1 family.

8364:snx18
gene id: 8364:snx18
uniprot id: Q5U4P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

8364:pot1
gene id: 8364:pot1
uniprot id: A0A8J0S985
uniprot id: Q6QLL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the telombin family.
messages: Nucleus
messages: telomere

8364:tfeb
gene id: 8364:tfeb
uniprot id: A0A8J1J5S8
uniprot id: Q08D59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

8364:man1c1
gene id: 8364:man1c1
uniprot id: A0A7D9NLA5
uniprot id: A0A8J0SGF4
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

8364:gdf11.1
gene id: 8364:gdf11.1
uniprot id: L7N3U0
names: Similarity
messages: Belongs to the TGF-beta family.

8364:LOC116411018
gene id: 8364:LOC116411018
uniprot id: A0A8J1JL87
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:hrh4.f1
gene id: 8364:hrh4.f1
uniprot id: A0A8J0R589
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:sbk1
gene id: 8364:sbk1
uniprot id: A0A803JKB1
uniprot id: A4IIN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm

8364:vps13a
gene id: 8364:vps13a
uniprot id: F6X0I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS13 family.
messages: Lipid droplet

8364:gnb4
gene id: 8364:gnb4
uniprot id: Q28G20
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

8364:ahdc1
gene id: 8364:ahdc1
uniprot id: F6U3B0
names: Subcellular Location Annotation
messages: Nucleus

8364:sbno1
gene id: 8364:sbno1
uniprot id: A0A6I8QF00
uniprot id: A0A8J0T122
uniprot id: F6YBA0
names: Similarity
messages: Belongs to the SBNO family.

8364:foxn1
gene id: 8364:foxn1
uniprot id: A0A7D9NLH6
names: Subcellular Location Annotation
messages: Nucleus

8364:srd5a2
gene id: 8364:srd5a2
uniprot id: A0A6I8PNY4
uniprot id: A0A8J0PJ13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane
messages: Microsome membrane

8364:ski
gene id: 8364:ski
uniprot id: A0A8J0R5Q3
uniprot id: F6XHC4
names: Similarity
messages: Belongs to the SKI family.

8364:cd44
gene id: 8364:cd44
uniprot id: A0A6I8RHB9
uniprot id: A0A803KIY4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: microvillus

8364:sulf2
gene id: 8364:sulf2
uniprot id: A0A6I8RZC8
uniprot id: Q6GL29
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

8364:gnrh1
gene id: 8364:gnrh1
uniprot id: A0A803KI17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GnRH family.
messages: Secreted
messages: Stimulates the secretion of gonadotropins.

8364:LOC101730868
gene id: 8364:LOC101730868
uniprot id: A0A6I8SPW5
uniprot id: A0A6I8SWC0
uniprot id: A0A6I8SY07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

8364:nthl1
gene id: 8364:nthl1
uniprot id: Q28J05
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nth/MutY family.
messages: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
messages: Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.
messages: Mitochondrion
messages: Nucleus

8364:LOC108648175
gene id: 8364:LOC108648175
uniprot id: A0A8J0T5S4
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:sh3bgrl2
gene id: 8364:sh3bgrl2
uniprot id: Q28FJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SH3BGR family.
messages: Nucleus

8364:c8a
gene id: 8364:c8a
uniprot id: Q6DK87
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted

8364:LOC116411040
gene id: 8364:LOC116411040
uniprot id: A0A8J1JLB8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:cyp20a1
gene id: 8364:cyp20a1
uniprot id: Q28C09
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:cnot1
gene id: 8364:cnot1
uniprot id: A0JP85
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CNOT1 family.
messages: Component of the CCR4-NOT complex.
messages: Contains Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, a motif known to be important for the association with nuclear receptors.
messages: Cytoplasm
messages: Nucleus
messages: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors (By similarity).

8364:LOC100487426
gene id: 8364:LOC100487426
uniprot id: A0A803K9H1
uniprot id: A0A8J1JVG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8364:LOC100494280
gene id: 8364:LOC100494280
uniprot id: A0A8J1JH24
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:parp4.1
gene id: 8364:parp4.1
uniprot id: A0A8J1J615
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

8364:ppm1h
gene id: 8364:ppm1h
uniprot id: Q28DF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Cytoplasm
messages: Nucleus

8364:tubb4b
gene id: 8364:tubb4b
uniprot id: A0A8J0SMF4
uniprot id: Q0IIR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

8364:vta1
gene id: 8364:vta1
uniprot id: Q66IK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTA1 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

8364:unc5b
gene id: 8364:unc5b
uniprot id: A0A6I8RLV7
uniprot id: A0A6I8S6J9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

8364:tmem184c
gene id: 8364:tmem184c
uniprot id: A9UM61
uniprot id: Q28CV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM184 family.
messages: May play a role in cell growth.
messages: Membrane

8364:eif6
gene id: 8364:eif6
uniprot id: Q6DDC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit.
messages: nucleolus

8364:upp2
gene id: 8364:upp2
uniprot id: A0A803KL20
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

8364:capzb
gene id: 8364:capzb
uniprot id: A0A803JBY2
uniprot id: A0A803JI50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein beta subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.
messages: cytoskeleton

8364:ddx18
gene id: 8364:ddx18
uniprot id: Q28D43
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

8364:htatsf1
gene id: 8364:htatsf1
uniprot id: A0A8J0QG56
uniprot id: B1H199
uniprot id: Q5EAL1
names: Similarity
messages: Belongs to the HTATSF1 family.

8364:dusp4
gene id: 8364:dusp4
uniprot id: Q28F83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

8364:celf5
gene id: 8364:celf5
uniprot id: A0JM51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus
messages: RNA-binding protein that may be implicated in the regulation of pre-mRNA alternative splicing.

8364:lrrc8e
gene id: 8364:lrrc8e
uniprot id: Q68F79
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Heterohexamer. Oligomerizes with other LRRC8 proteins (lrrc8a, lrrc8c, lrrc8d and/or lrrc8b) to form a heterohexamer. Detected in a channel complex that contains lrrc8a, lrrc8c and lrrc8e. In vivo, the subunit composition may depend primarily on expression levels, and heterooligomeric channels containing various proportions of the different LRRC8 proteins may coexist.
messages: Lysosome membrane
messages: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Mediates efflux of amino acids, such as aspartate, in response to osmotic stress. The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol. Channel activity requires lrrc8a plus at least one other family member (lrrc8b, lrrc8c, lrrc8d or lrrc8e); channel characteristics depend on the precise subunit composition. Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis.
messages: The volume-regulated anion channel (VRAC) channel forms a trimer of dimers, with symmetry mismatch between the pore-forming domain and the cytosolic LRR repeats, a topology similar to gap junction proteins.

8364:mrpl52
gene id: 8364:mrpl52
uniprot id: A0A6I8PPN1
uniprot id: A0A6I8SFD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL52 family.
messages: Mitochondrion

8364:clcn1
gene id: 8364:clcn1
uniprot id: A0A7D9NJN3
names: Subcellular Location Annotation
messages: Membrane

8364:LOC101732943
gene id: 8364:LOC101732943
uniprot id: A0A8J0SB78
uniprot id: A0A8J0SZT9
names: Subcellular Location Annotation
messages: Secreted

8364:cdadc1
gene id: 8364:cdadc1
uniprot id: F6SQI7
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

8364:naa30
gene id: 8364:naa30
uniprot id: A0A803KF75
uniprot id: F6UW04
names: Similarity
messages: Belongs to the acetyltransferase family. MAK3 subfamily.

8364:LOC780339
gene id: 8364:LOC780339
uniprot id: Q08CX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Binds predominantly GDP, and also GTP.
messages: Homodimer.
messages: perinuclear region

8364:ubiad1
gene id: 8364:ubiad1
uniprot id: A0A6I8Q056
uniprot id: Q28HR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Mitochondrion membrane
messages: Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress.

8364:arhgdib
gene id: 8364:arhgdib
uniprot id: Q6DF26
names: Similarity
messages: Belongs to the Rho GDI family.

8364:LOC100487792
gene id: 8364:LOC100487792
uniprot id: A0A8J1JUQ0
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100496974
gene id: 8364:LOC100496974
uniprot id: A0A8J0R2W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:tmtops2
gene id: 8364:tmtops2
uniprot id: A0A0P0YQA4
uniprot id: A0A8J0T0P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

8364:LOC101733362
gene id: 8364:LOC101733362
uniprot id: F6RFQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:calr3
gene id: 8364:calr3
uniprot id: F7E4B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

8364:gemin2
gene id: 8364:gemin2
uniprot id: F6TG06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gemin-2 family.
messages: Cytoplasm
messages: Part of the core SMN complex.
messages: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.

8364:col4a5
gene id: 8364:col4a5
uniprot id: A0A6I8QYG5
uniprot id: A0A6I8SI48
uniprot id: A0A7D9NK48
uniprot id: A0A8J0R3V1
uniprot id: A0A8J0R6B6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

8364:scn3b
gene id: 8364:scn3b
uniprot id: A0A8J0SIM3
uniprot id: A0A8J1JSL4
uniprot id: F7B7Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

8364:LOC100495591
gene id: 8364:LOC100495591
uniprot id: A0A8J1IT03
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC100495963
gene id: 8364:LOC100495963
uniprot id: A0A8J1J722
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

8364:b3gat1l
gene id: 8364:b3gat1l
uniprot id: F7DRX3
uniprot id: Q599K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:LOC116412262
gene id: 8364:LOC116412262
uniprot id: A0A8J1JVQ5
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8364:ninj2
gene id: 8364:ninj2
uniprot id: A0A803K4K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Membrane

8364:cdc42se2
gene id: 8364:cdc42se2
uniprot id: Q28GG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly.
messages: cytoskeleton

8364:gpc3
gene id: 8364:gpc3
uniprot id: A0A6I8SBK0
uniprot id: A0A8J1INN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

8364:yars1
gene id: 8364:yars1
uniprot id: Q6DIJ1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: The nuclear localization signal, which mediates localization to the nucleus, is also important for interacting with tRNA(Tyr), suggesting that it is sterically blocked when tRNA(Tyr) is bound.

8364:fgf14
gene id: 8364:fgf14
uniprot id: A0A803KJT6
uniprot id: A0A8J0SR72
uniprot id: F7E816
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

8364:alg10
gene id: 8364:alg10
uniprot id: Q08D71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Membrane

8364:ephb1
gene id: 8364:ephb1
uniprot id: A0A6I8R958
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: dendrite

8364:mrps6
gene id: 8364:mrps6
uniprot id: A4IGR2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.

8364:LOC116408371
gene id: 8364:LOC116408371
uniprot id: A0A8J1J1W3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:wdr83os
gene id: 8364:wdr83os
uniprot id: F6QLB4
names: Similarity
messages: Belongs to the Asterix family.

8364:disp3.2
gene id: 8364:disp3.2
uniprot id: A0A8J1JUX8
names: Subcellular Location Annotation
messages: Membrane

8364:cd79a
gene id: 8364:cd79a
uniprot id: A0A6I8PTD9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:miga1
gene id: 8364:miga1
uniprot id: B0JZD1
uniprot id: F6SNJ4
names: Similarity
messages: Belongs to the mitoguardin family.

8364:wnt5a
gene id: 8364:wnt5a
uniprot id: A0A803K929
uniprot id: A0A803KBZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8364:wnk2
gene id: 8364:wnk2
uniprot id: A0A6I8QIM0
uniprot id: A0A6I8RTJ3
uniprot id: A0A8J1JGZ9
uniprot id: A0A8J1JH00
uniprot id: A0A8J1JH05
uniprot id: A0A8J1JKI6
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

8364:cap2
gene id: 8364:cap2
uniprot id: G1K3K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane

8364:b3galt5.2
gene id: 8364:b3galt5.2
uniprot id: A0A6I8PVV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:flna
gene id: 8364:flna
uniprot id: A0A6I8QK80
uniprot id: A0A6I8QUV6
uniprot id: A0A6I8S7R2
uniprot id: A0A8J0SLA0
uniprot id: A0A8J0T665
names: Similarity
messages: Belongs to the filamin family.

8364:LOC116409607
gene id: 8364:LOC116409607
uniprot id: A0A8J1JC20
names: Subcellular Location Annotation
messages: Membrane

8364:phkb
gene id: 8364:phkb
uniprot id: A0A6I8Q841
uniprot id: A0A6I8SAH9
uniprot id: A0A8J0R149
uniprot id: A0A8J0R4C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.

8364:LOC116410980
gene id: 8364:LOC116410980
uniprot id: A0A8J1JNI3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:tsen54
gene id: 8364:tsen54
uniprot id: A0A803JKM6
uniprot id: A4II78
names: Similarity
messages: Belongs to the SEN54 family.

8364:gsr
gene id: 8364:gsr
uniprot id: A0A6I8RRT3
uniprot id: B1WBJ3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Maintains high levels of reduced glutathione in the cytosol.

8364:ltc4s.2
gene id: 8364:ltc4s.2
uniprot id: F7DHS8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:pomt2
gene id: 8364:pomt2
uniprot id: A0A6I8QLH7
uniprot id: A0A8J0R432
uniprot id: A0A8J0SWI8
uniprot id: A0A8J1ITX9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

8364:tmem255a
gene id: 8364:tmem255a
uniprot id: A0A6I8Q258
uniprot id: A0A803KKQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

8364:sdhb
gene id: 8364:sdhb
uniprot id: B0BM36
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) sdha, iron-sulfur protein (IP) sdhb, and a cytochrome b composed of sdhc and sdhd.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

8364:mcl1
gene id: 8364:mcl1
uniprot id: A0A6I8PM94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: nucleoplasm

8364:dipk1a
gene id: 8364:dipk1a
uniprot id: A0A803J8H4
uniprot id: A4IGK1
uniprot id: F7DSB4
names: Similarity
messages: Belongs to the DIPK family.

8364:crygdl.22
gene id: 8364:crygdl.22
uniprot id: A0A8J0QVG3
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:scp2
gene id: 8364:scp2
uniprot id: Q5EBE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Cytoplasm
messages: Mitochondrion

8364:rbks
gene id: 8364:rbks
uniprot id: A0A803JDH6
uniprot id: Q5M7S1
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

8364:nek2
gene id: 8364:nek2
uniprot id: A0A6I8Q0M3
uniprot id: A0A8J1IL35
uniprot id: F7B0N9
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:atp5pd
gene id: 8364:atp5pd
uniprot id: F6W0P9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase d subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

8364:fbn3
gene id: 8364:fbn3
uniprot id: A0A6I8RWU7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:rpl12
gene id: 8364:rpl12
uniprot id: A0A803K2A6
uniprot id: A0A8J1IL95
uniprot id: Q28FK6
uniprot id: Q68F82
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Binds directly to 26S ribosomal RNA.

8364:LOC116412046
gene id: 8364:LOC116412046
uniprot id: A0A8J1JTQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8364:pik3r3
gene id: 8364:pik3r3
uniprot id: Q28IS1
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

8364:c16orf71
gene id: 8364:c16orf71
uniprot id: A0A8J0QM05
names: Function
names: Subcellular Location Annotation
messages: Dynein axonemal particle
messages: In cyliated cells, dynein axonemal particle-specific protein required for deployment of ODA to the axoneme. Interacts with outer dynein arm (ODA) subunits.

8364:nde1
gene id: 8364:nde1
uniprot id: Q66JL0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nudE family.
messages: Phosphorylated in mitosis.
messages: Required for centrosome duplication and formation and function of the mitotic spindle.
messages: Self-associates. Interacts with pafah1b1 (By similarity).
messages: centrosome
messages: cytoskeleton
messages: spindle

8364:plppr1
gene id: 8364:plppr1
uniprot id: A0A8J1JHX1
uniprot id: A4II83
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Cell membrane
messages: Has no 2-lysophosphatidate/LPA phosphatase activity. This is supported by the fact that the phosphatase sequence motifs as well as the His residue acting as a nucleophile in active phosphatases of the PA-phosphatase related phosphoesterase family are not conserved.
messages: May play a role in neurite outgrowth and neurogenesis.
messages: Membrane
messages: neuron projection

8364:slc2a8
gene id: 8364:slc2a8
uniprot id: A0A803JD94
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

8364:hsd17b12
gene id: 8364:hsd17b12
uniprot id: Q28IU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
messages: Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.
messages: Endoplasmic reticulum membrane

8364:icmt
gene id: 8364:icmt
uniprot id: F7EBZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:LOC108645662
gene id: 8364:LOC108645662
uniprot id: A0A8J0SY21
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:gadd45a
gene id: 8364:gadd45a
uniprot id: A0A8J0SK44
uniprot id: Q28FH5
names: Similarity
messages: Belongs to the GADD45 family.

8364:prxl2a
gene id: 8364:prxl2a
uniprot id: A0JPD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
messages: Cytoplasm
messages: Involved in redox regulation of the cell. Acts as an antioxidant (By similarity).

8364:papola
gene id: 8364:papola
uniprot id: A0A8J0SKB9
uniprot id: A0A8J0SSG7
uniprot id: B5DEV0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Binds 2 magnesium ions. Also active with manganese.
messages: Nucleus
messages: Polymerase that creates the 3'-poly(A) tail of mRNA's.

8364:LOC100486384
gene id: 8364:LOC100486384
uniprot id: A0A5S6KTE9
uniprot id: F6U264
names: Subcellular Location Annotation
messages: Nucleus

8364:nek3
gene id: 8364:nek3
uniprot id: Q6DJQ5
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:fktn
gene id: 8364:fktn
uniprot id: A4II65
names: Similarity
messages: Belongs to the LicD transferase family.

8364:med1
gene id: 8364:med1
uniprot id: A1L0Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

8364:spsb4
gene id: 8364:spsb4
uniprot id: A0A6I8RXC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Cytoplasm

8364:dnajc10
gene id: 8364:dnajc10
uniprot id: A0A6I8Q7I8
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.
messages: Endoplasmic reticulum lumen

8364:mbl2
gene id: 8364:mbl2
uniprot id: A0A6I8SN86
names: Similarity
names: Subunit
messages: Belongs to the SFTPD family.
messages: Oligomeric complex of 4 set of homotrimers.

8364:LOC100485533
gene id: 8364:LOC100485533
uniprot id: A0A8J1IPW1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:xdh
gene id: 8364:xdh
uniprot id: F7CQN1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Peroxisome

8364:myo9b
gene id: 8364:myo9b
uniprot id: A0A6I8Q118
uniprot id: A0A8J0SX65
uniprot id: A0A8J0SX70
uniprot id: A0A8J0T438
uniprot id: A0A8J0T445
uniprot id: A0A8J0T6G6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:lta4h
gene id: 8364:lta4h
uniprot id: Q6GL78
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

8364:ces3.5
gene id: 8364:ces3.5
uniprot id: A0A8J1JJ35
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

8364:atp6v0d1
gene id: 8364:atp6v0d1
uniprot id: A0JLY8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

8364:stk35
gene id: 8364:stk35
uniprot id: Q6GLH7
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:abhd11
gene id: 8364:abhd11
uniprot id: Q0V9K2
names: Similarity
messages: Belongs to the AB hydrolase superfamily.

8364:slc30a1
gene id: 8364:slc30a1
uniprot id: Q66KD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

8364:LOC108645185
gene id: 8364:LOC108645185
uniprot id: A0A8J1JYJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8364:LOC100487846
gene id: 8364:LOC100487846
uniprot id: A0A8J0SUU4
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:LOC100496752
gene id: 8364:LOC100496752
uniprot id: F6XTM2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:bix1.2
gene id: 8364:bix1.2
uniprot id: A0A8J1JHR6
uniprot id: B4F6G7
uniprot id: Q4JF50
names: Subcellular Location Annotation
messages: Nucleus

8364:ddit3
gene id: 8364:ddit3
uniprot id: Q28E92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Cytoplasm

8364:tbcc
gene id: 8364:tbcc
uniprot id: A0A8J0QPZ9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCC family.
messages: Cytoplasm
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.

8364:pgr
gene id: 8364:pgr
uniprot id: A0A8J0QL47
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Cytoplasm
messages: Nucleus
messages: Steroid hormone receptor involved in the regulation of eukaryotic gene expression which affects cellular proliferation and differentiation in target tissues.

8364:cyp39a1
gene id: 8364:cyp39a1
uniprot id: F6PLK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

8364:dctn1
gene id: 8364:dctn1
uniprot id: A0A6I8SEY7
uniprot id: A0A6I8SH07
uniprot id: A0A8J0QRY9
uniprot id: A0A8J0QY33
uniprot id: A0A8J0R071
uniprot id: A0A8J0R0Z6
uniprot id: A0A8J0SB49
uniprot id: A0A8J0SD17
uniprot id: A0A8J0SDU8
uniprot id: A0A8J0SE26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin 150 kDa subunit family.
messages: cell cortex
messages: cytoskeleton

8364:cd3g
gene id: 8364:cd3g
uniprot id: F6VBE7
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100491742
gene id: 8364:LOC100491742
uniprot id: A0A1B8Y7U9
uniprot id: A0A803JQT0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Membrane

8364:rps6ka3
gene id: 8364:rps6ka3
uniprot id: A0A6I8R6S5
uniprot id: A0A6I8S147
uniprot id: A0A6I8SAS5
uniprot id: A0A8J1J410
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

8364:LOC100488285
gene id: 8364:LOC100488285
uniprot id: A0A8J0QZ65
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100490735
gene id: 8364:LOC100490735
uniprot id: A0A8J0SD96
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:or13c2
gene id: 8364:or13c2
uniprot id: A0A8J0QMA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:ss18
gene id: 8364:ss18
uniprot id: A0A6I8PTQ5
uniprot id: A0A6I8R740
uniprot id: A0A8J0SRI3
uniprot id: Q0VGY6
names: Similarity
messages: Belongs to the SS18 family.

8364:LOC116411041
gene id: 8364:LOC116411041
uniprot id: A0A8J1JLB7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC105948062
gene id: 8364:LOC105948062
uniprot id: A0A803JY47
names: Similarity
messages: Belongs to the cyclin family.

8364:LOC100488935
gene id: 8364:LOC100488935
uniprot id: F7AIL8
names: Similarity
messages: Belongs to the TGF-beta family.

8364:pigu
gene id: 8364:pigu
uniprot id: A0A8J0SZK9
uniprot id: Q28CK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:LOC101733085
gene id: 8364:LOC101733085
uniprot id: A0A8J0R3J9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: nucleoplasm

8364:LOC116412094
gene id: 8364:LOC116412094
uniprot id: A0A8J1JUA1
names: Similarity
messages: Belongs to the Speedy/Ringo family.

8364:neu3.3
gene id: 8364:neu3.3
uniprot id: F6V078
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

8364:parvb
gene id: 8364:parvb
uniprot id: F6UFK5
uniprot id: Q6GLA6
names: Similarity
messages: Belongs to the parvin family.

8364:renbp
gene id: 8364:renbp
uniprot id: A0A8J0T593
uniprot id: A9JTM3
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

8364:mindy2
gene id: 8364:mindy2
uniprot id: A0A8J0QU02
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

8364:LOC101731006
gene id: 8364:LOC101731006
uniprot id: A0A1B8Y809
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:camk2a
gene id: 8364:camk2a
uniprot id: A0A6I8SFN9
uniprot id: A0A8J0S8U1
uniprot id: A0A8J0SEG8
uniprot id: A0A8J1J692
uniprot id: A0A8J1J695
uniprot id: A4IIE5
uniprot id: F6YQ17
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

8364:cpne5
gene id: 8364:cpne5
uniprot id: A4IIK4
names: Similarity
messages: Belongs to the copine family.

8364:mterf1
gene id: 8364:mterf1
uniprot id: A0A8J0PIX2
names: Similarity
messages: Belongs to the mTERF family.

8364:flnb
gene id: 8364:flnb
uniprot id: A0A6I8T003
uniprot id: A0A8J0QMD8
uniprot id: A0A8J0R1A6
uniprot id: A0A8J0R4G5
uniprot id: A0A8J1JGW0
uniprot id: A0A8J1JJB4
names: Similarity
messages: Belongs to the filamin family.

8364:LOC101730739
gene id: 8364:LOC101730739
uniprot id: A0A8J0SGX6
uniprot id: A0A8J1J7S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:LOC100495473
gene id: 8364:LOC100495473
uniprot id: F6YY56
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

8364:ank1
gene id: 8364:ank1
uniprot id: A0A8J0S9N8
uniprot id: A0A8J0S9P2
uniprot id: A0A8J0SFS3
uniprot id: A0A8J0SFS8
uniprot id: A0A8J0SFT3
uniprot id: A0A8J0SHH4
uniprot id: A0A8J0SHI2
uniprot id: A0A8J0SIN9
uniprot id: A0A8J0SIP1
uniprot id: A0A8J0SIP4
uniprot id: A0A8J0SIP5
uniprot id: A0A8J0SIQ1
uniprot id: A0A8J1JBC8
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

8364:anapc16
gene id: 8364:anapc16
uniprot id: A0A8J0SQH0
uniprot id: A0A8J0ST47
uniprot id: A0A8J0STE2
uniprot id: Q6DJQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APC16 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Cytoplasm
messages: Nucleus
messages: The APC/C is composed of at least 12 subunits. ANAPC16 associates with the rest of the complex independently of ANAPC2 and ANAPC11 (By similarity).
messages: kinetochore

8364:ints9
gene id: 8364:ints9
uniprot id: A0A8J0PIK8
uniprot id: A0A8J1JI75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
messages: Nucleus

8364:zdhhc20
gene id: 8364:zdhhc20
uniprot id: A0A8J0T1I2
uniprot id: Q28H20
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8364:cxcr3
gene id: 8364:cxcr3
uniprot id: Q5XGJ2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:svbp
gene id: 8364:svbp
uniprot id: A0A6I8RF78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVBP family.
messages: Secreted
messages: cytoskeleton

8364:prmt7
gene id: 8364:prmt7
uniprot id: A0A8J0PJW7
uniprot id: A0A8J0ST16
uniprot id: A0A8J1JG43
uniprot id: F7BU82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
messages: Nucleus
messages: cytosol

8364:LOC108648340
gene id: 8364:LOC108648340
uniprot id: A0A8J1ISJ7
names: Similarity
messages: Belongs to the SUA5 family.

8364:LOC100498019
gene id: 8364:LOC100498019
uniprot id: A0A8J1JWY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

8364:LOC101735260
gene id: 8364:LOC101735260
uniprot id: A0A8J0R6C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100144987
gene id: 8364:LOC100144987
uniprot id: B0BM83
uniprot id: F6QI09
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ITPK1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.
messages: Monomer.

8364:c3orf70
gene id: 8364:c3orf70
uniprot id: F6TD01
names: Similarity
messages: Belongs to the UPF0524 family.

8364:cc2d1b
gene id: 8364:cc2d1b
uniprot id: A0A6I8SHI7
uniprot id: A0A8J1JIG3
names: Similarity
messages: Belongs to the CC2D1 family.

8364:LOC100492282
gene id: 8364:LOC100492282
uniprot id: A0A803JDB1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:tpd52l1
gene id: 8364:tpd52l1
uniprot id: A0A803K3J7
uniprot id: F6VG04
names: Similarity
messages: Belongs to the TPD52 family.

8364:LOC100496398
gene id: 8364:LOC100496398
uniprot id: A0A803K601
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:LOC100492550
gene id: 8364:LOC100492550
uniprot id: A0A6I8T260
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

8364:LOC613053
gene id: 8364:LOC613053
uniprot id: A0A6I8QPE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Cell membrane
messages: Membrane
messages: Mitochondrion
messages: Nucleus
messages: Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.
messages: perinuclear region
messages: trans-Golgi network membrane

8364:katnal2
gene id: 8364:katnal2
uniprot id: A0A346BPW0
uniprot id: A0A6I8Q5K9
uniprot id: A0JMA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.
messages: Cytoplasm
messages: Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
messages: cytoskeleton
messages: spindle
messages: spindle pole

8364:terf2
gene id: 8364:terf2
uniprot id: A0A8J0SSY5
uniprot id: B8QB44
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
messages: Homodimer.
messages: Nucleus

8364:pde7a
gene id: 8364:pde7a
uniprot id: A0A6I8S179
uniprot id: A0A6I8SHM8
uniprot id: A0A8J0QX24
uniprot id: A0A8J1JQU6
uniprot id: A0A8J1JTA6
uniprot id: F7BCQ1
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8364:bop1
gene id: 8364:bop1
uniprot id: A4IHS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat BOP1/ERB1 family.
messages: Component of the PeBoW complex, composed of bop1, pes1 and wdr12. The complex is held together by bop1, which interacts with pes1 via its N-terminal domain and with wdr12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The PeBoW complex associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

8364:cers2
gene id: 8364:cers2
uniprot id: F6XWC3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

8364:snx3
gene id: 8364:snx3
uniprot id: F7AZV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome
messages: Endosome
messages: phagosome

8364:gpatch1
gene id: 8364:gpatch1
uniprot id: B1H130
uniprot id: F7C3S1
names: Similarity
messages: Belongs to the GPATCH1 family.

8364:rpn1
gene id: 8364:rpn1
uniprot id: Q6P1S9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

8364:cdh12
gene id: 8364:cdh12
uniprot id: F7CIG1
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane

8364:tmbim4
gene id: 8364:tmbim4
uniprot id: Q6DJB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

8364:spag9
gene id: 8364:spag9
uniprot id: A0A6I8S999
uniprot id: L7N391
names: Similarity
messages: Belongs to the JIP scaffold family.

8364:sec24c
gene id: 8364:sec24c
uniprot id: A0A6I8QZX3
uniprot id: A0A6I8SV10
uniprot id: A0A7D9NMF2
uniprot id: A0A8J0QFY7
uniprot id: A0A8J1JSX4
uniprot id: A0A8J1JWQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

8364:cldn8.1
gene id: 8364:cldn8.1
uniprot id: A0A803K4E8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8364:LOC100135146
gene id: 8364:LOC100135146
uniprot id: A9JSE2
names: Similarity
messages: Belongs to the HEBP family.

8364:cse1l
gene id: 8364:cse1l
uniprot id: A0A6I8QY78
uniprot id: B2GU98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPO2/CSE1 family.
messages: Cytoplasm

8364:il17rd
gene id: 8364:il17rd
uniprot id: F6ZRR0
names: Subcellular Location Annotation
messages: Membrane

8364:LOC101733075
gene id: 8364:LOC101733075
uniprot id: A0A8J1JVD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:brd9
gene id: 8364:brd9
uniprot id: Q6NVM8
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds acetylated histones H3 and H4. Binds butyrylated histone H4.
messages: Nucleus
messages: Plays a role in chromatin remodeling and regulation of transcription. Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated.
messages: The Bromo domain mediates interaction with histones that have acetylated lysine residues at specific positions. Also recognizes and binds histones that are butyrylated.

8364:LOC101730761
gene id: 8364:LOC101730761
uniprot id: Q6DK82
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:unc50
gene id: 8364:unc50
uniprot id: B5DEV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-50 family.
messages: Membrane
messages: Nucleus inner membrane

8364:mars2
gene id: 8364:mars2
uniprot id: A0A6I8QWH4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

8364:KEG17 p07
gene id: 8364:KEG17_p07
uniprot id: Q5G7I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane

8364:polr2l.1
gene id: 8364:polr2l.1
uniprot id: Q28GI6
names: Similarity
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.

8364:kcnk16
gene id: 8364:kcnk16
uniprot id: A0A6I8RSF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

8364:hesx1
gene id: 8364:hesx1
uniprot id: A0A1B8Y6F7
uniprot id: Q28J15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ANF homeobox family.
messages: Interacts (via N-terminus) with zyx.
messages: Nucleus
messages: Regulates the earliest stages of development of the anterior neural plate. Plays a role in forebrain development by inhibiting the expression of otx2 and pax6 in the rostral region of the anterior neural plate. Necessary for both neural differentiation and neural patterning. Controls Spemann organizer development. May act as a transcriptional repressor (By similarity).

8364:LOC116408723
gene id: 8364:LOC116408723
uniprot id: A0A8J1J319
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

8364:LOC108646191
gene id: 8364:LOC108646191
uniprot id: A0A8J1JBD3
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8364:fnta
gene id: 8364:fnta
uniprot id: F7E5Z4
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

8364:rrp15
gene id: 8364:rrp15
uniprot id: A0A803JV35
names: Similarity
messages: Belongs to the RRP15 family.

8364:cdk5rap3
gene id: 8364:cdk5rap3
uniprot id: A0A8J1IWG3
uniprot id: Q5I0B6
names: Similarity
messages: Belongs to the CDK5RAP3 family.

8364:LOC100490227
gene id: 8364:LOC100490227
uniprot id: A0A8J0QYS3
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

8364:bmt2
gene id: 8364:bmt2
uniprot id: A0A8J0S9F4
uniprot id: A0A8J1J7B6
uniprot id: A0A8J1J9Q8
uniprot id: A4IIA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BMT2 family.
messages: Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.
messages: Interacts with the GATOR1 complex; interaction is disrupted when bmt2/samtor binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when bmt2/samtor binds S-adenosyl-L-methionine.
messages: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.

8364:mrpl16
gene id: 8364:mrpl16
uniprot id: A0A8J0PJG1
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

8364:ccny
gene id: 8364:ccny
uniprot id: A0A6I8SQ47
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

8364:LOC100492285
gene id: 8364:LOC100492285
uniprot id: A0A8J0QSZ7
names: Subcellular Location Annotation
messages: Membrane

8364:rab33a
gene id: 8364:rab33a
uniprot id: F7AXL2
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

8364:fam163b
gene id: 8364:fam163b
uniprot id: A0A1B8Y0K4
uniprot id: Q0VFM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

8364:ogfod3
gene id: 8364:ogfod3
uniprot id: Q5XGE0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OGFOD3 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Membrane

8364:scn1b
gene id: 8364:scn1b
uniprot id: A0A6I8Q6I0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

8364:alox12b
gene id: 8364:alox12b
uniprot id: Q5FW07
names: Caution
names: Cofactor
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:itga4
gene id: 8364:itga4
uniprot id: F6Q166
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

8364:arl8a
gene id: 8364:arl8a
uniprot id: Q6P8C8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Late endosome membrane
messages: Lysosome membrane
messages: May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity).

8364:rce1
gene id: 8364:rce1
uniprot id: B7ZT68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U48 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:pnrc2
gene id: 8364:pnrc2
uniprot id: Q68EQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNRC family. PNRC2 subfamily.
messages: Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for upf1/rent1 localization to the P-body. Also acts as a nuclear receptor coactivator (By similarity).
messages: Nucleus
messages: P-body

8364:anapc1
gene id: 8364:anapc1
uniprot id: Q08D52
names: Similarity
messages: Belongs to the APC1 family.

8364:timm23
gene id: 8364:timm23
uniprot id: Q5XH94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of timm23, timm17 and timm50. The complex interacts with the timm44 component of the PAM complex (By similarity).
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Mitochondrion inner membrane

8364:fan1
gene id: 8364:fan1
uniprot id: A0A8J0QQA9
uniprot id: F7DWG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAN1 family.
messages: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
messages: Nucleus

8364:slc31a1
gene id: 8364:slc31a1
uniprot id: Q6NVQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

8364:rtf2
gene id: 8364:rtf2
uniprot id: A0A1B8Y5J8
uniprot id: Q6NVS6
names: Similarity
messages: Belongs to the rtf2 family.

8364:gfra4
gene id: 8364:gfra4
uniprot id: A0A6I8PT46
names: Similarity
messages: Belongs to the GDNFR family.

8364:g6pc.3
gene id: 8364:g6pc.3
uniprot id: F6T2L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

8364:mip
gene id: 8364:mip
uniprot id: A4IGW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

8364:scamp5.1
gene id: 8364:scamp5.1
uniprot id: A0A8J0STA0
uniprot id: Q28F21
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Belongs to the SCAMP family. SCAMP5 subfamily.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Recycling endosome membrane
messages: Required for the calcium-dependent exocytosis of signal sequence-containing cytokines. Probably acts in cooperation with the SNARE machinery (By similarity).
messages: synaptic vesicle membrane
messages: trans-Golgi network membrane

8364:LOC100135367
gene id: 8364:LOC100135367
uniprot id: A0A8J1JMG4
uniprot id: B7ZU46
uniprot id: F6RIB7
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

8364:snrpd3
gene id: 8364:snrpd3
uniprot id: Q28GL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

8364:irx5
gene id: 8364:irx5
uniprot id: A0A803JFD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

8364:LOC105948115
gene id: 8364:LOC105948115
uniprot id: A0A8J1IPT4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:hsp90ab1
gene id: 8364:hsp90ab1
uniprot id: Q5BL42
names: Similarity
messages: Belongs to the heat shock protein 90 family.

8364:zfyve16
gene id: 8364:zfyve16
uniprot id: A0A6I8RHJ5
uniprot id: A0A6I8S5Q9
uniprot id: A0A8J1IV09
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane

8364:gnptab
gene id: 8364:gnptab
uniprot id: A0A8J0S8S2
uniprot id: A0A8J0SHB1
uniprot id: A1A5F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the stealth family.
messages: Membrane

8364:ccdc160
gene id: 8364:ccdc160
uniprot id: A9JSR5
names: Similarity
messages: Belongs to the CCDC160 family.

8364:odam
gene id: 8364:odam
uniprot id: B9UIU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ODAM family.
messages: Cytoplasm
messages: Interacts (via C-terminus) with ARHGEF5.
messages: Nucleus
messages: Secreted
messages: Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.

8364:cuta
gene id: 8364:cuta
uniprot id: F7BR45
names: Similarity
names: Subunit
messages: Belongs to the CutA family.
messages: Homotrimer.

8364:sntg2
gene id: 8364:sntg2
uniprot id: A0A8J1JL57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: cytoskeleton

8364:ints3
gene id: 8364:ints3
uniprot id: A0A8J1IMJ3
uniprot id: A0A8J1IPU0
names: Similarity
messages: Belongs to the Integrator subunit 3 family.

8364:prpf31
gene id: 8364:prpf31
uniprot id: Q6NVP6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRP31 family.
messages: Cajal body
messages: Identified in the spliceosome B complex. Component of the U4/U6-U5 tri-snRNP complex. Component of some MLL1/MLL complex.
messages: Interacts with the snRNP via the Nop domain.
messages: Involved in pre-mRNA splicing as component of the spliceosome. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.
messages: Nucleus
messages: Nucleus speckle
messages: The coiled coil domain is formed by two non-contiguous helices.

8364:cryaa
gene id: 8364:cryaa
uniprot id: F7DB35
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

8364:LOC101730357
gene id: 8364:LOC101730357
uniprot id: A0A8J1JQI0
names: Similarity
messages: Belongs to the apolipoprotein L family.

8364:zfp36l2
gene id: 8364:zfp36l2
uniprot id: A4IIN5
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated (By similarity).
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (By similarity). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (By similarity). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (By similarity). Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Required for tubulogenesis during pronephros development (By similarity).

8364:fam118b
gene id: 8364:fam118b
uniprot id: A0A6I8Q858
uniprot id: A0A6I8REV5
uniprot id: A0A803JUF8
uniprot id: A0A8J1JSI0
uniprot id: A0A8J1JWB4
uniprot id: Q6DF29
names: Similarity
messages: Belongs to the FAM118 family.

8364:pigb
gene id: 8364:pigb
uniprot id: A0A8J0T1D1
uniprot id: B1WBF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:itga2
gene id: 8364:itga2
uniprot id: A0A6I8SH64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

8364:LOC105948119
gene id: 8364:LOC105948119
uniprot id: A0A8J1IT08
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:kcnab3
gene id: 8364:kcnab3
uniprot id: A0A8J1J7P2
uniprot id: Q0IIY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cytoplasm

8364:lyg2
gene id: 8364:lyg2
uniprot id: Q5FW09
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

8364:bcs1l
gene id: 8364:bcs1l
uniprot id: F6RKM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

8364:gabrb2
gene id: 8364:gabrb2
uniprot id: A4IIN3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:ube4b
gene id: 8364:ube4b
uniprot id: A0A6I8Q2W8
uniprot id: A0A6I8RF94
uniprot id: A0A8J0R616
uniprot id: A0A8J0T2H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

8364:arfgef2
gene id: 8364:arfgef2
uniprot id: A0A6I8RM18
uniprot id: A0A8J0T6N2
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

8364:cnga3
gene id: 8364:cnga3
uniprot id: A0A6I8Q4T5
uniprot id: A0A8J1J779
uniprot id: F6TBQ4
names: Subcellular Location Annotation
messages: Membrane

8364:pias1
gene id: 8364:pias1
uniprot id: A0A8J0QZF8
uniprot id: F6YUL3
names: Similarity
messages: Belongs to the PIAS family.

8364:mfge8
gene id: 8364:mfge8
uniprot id: Q0VA62
uniprot id: Q6P1V9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:acyp1
gene id: 8364:acyp1
uniprot id: B7ZSP5
uniprot id: Q28FK7
names: Similarity
messages: Belongs to the acylphosphatase family.

8364:gpr146
gene id: 8364:gpr146
uniprot id: A4QNI7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:hspa4
gene id: 8364:hspa4
uniprot id: Q6P3M8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Interacts with TJP1/ZO-1.

8364:pou4f1.2
gene id: 8364:pou4f1.2
uniprot id: A4IGJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

8364:med10
gene id: 8364:med10
uniprot id: Q6DJ25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

8364:melk
gene id: 8364:melk
uniprot id: A0A8J1JFE7
uniprot id: Q28GW8
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Activated by autophosphorylation of the T-loop at Thr-169 and Ser-173: in contrast to other members of the SNF1 subfamily, phosphorylation at Thr-169 is not mediated by STK11/LKB1 but via autophosphorylation instead.
messages: Autophosphorylated: autophosphorylation of the T-loop at Thr-169 and Ser-173 is required for activation. Phosphorylated by the maturation promoting factor (MPF), composed of cdk1 and a cyclin-B. Also phosphorylated by some MAPK. Phosphorylated during oocyte maturation. Dephosphorylation destabilizes the protein (By similarity).
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Cell membrane
messages: Degraded when cells exit mitosis.
messages: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Also plays a role in primitive hematopoiesis, possibly by affecting the expression of genes critical for hematopoiesis. Plays a role in cytokinesis during early development (By similarity).
messages: The KA1 domain mediates binding to phospholipids and targeting to membranes.

8364:LOC100494139
gene id: 8364:LOC100494139
uniprot id: A0A6I8S7S5
uniprot id: A0A8J1JBY9
uniprot id: A0A8J1JFF6
names: Similarity
messages: Belongs to the NXPE family.

8364:mettl3
gene id: 8364:mettl3
uniprot id: Q28H22
names: Similarity
messages: Belongs to the MT-A70-like family.

8364:chrm1
gene id: 8364:chrm1
uniprot id: A0A6I8SRX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

8364:LOC101734862
gene id: 8364:LOC101734862
uniprot id: A0A6I8QAK0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:prom1
gene id: 8364:prom1
uniprot id: A0A8J1JI96
uniprot id: A0A8J1JLC3
uniprot id: A0A8J1JMN9
uniprot id: A0A8J1JQX2
uniprot id: A0A8J1JRL1
uniprot id: A0A8J1JRS0
uniprot id: A0A8J1JSM3
uniprot id: E9LYZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

8364:slit2
gene id: 8364:slit2
uniprot id: A0A6I8SZ86
uniprot id: A0A8J0QRS5
uniprot id: A0A8J0S6N3
uniprot id: A0A8J1J024
uniprot id: A0A8J1J2E9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:mrps24
gene id: 8364:mrps24
uniprot id: A0A8J0PHV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Mitochondrion

8364:b3gnt10
gene id: 8364:b3gnt10
uniprot id: A0A8J0QKN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:csf3
gene id: 8364:csf3
uniprot id: A0A803JQG8
names: Similarity
messages: Belongs to the IL-6 superfamily.

8364:ppil1
gene id: 8364:ppil1
uniprot id: Q6DFT0
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

8364:suv39h2
gene id: 8364:suv39h2
uniprot id: A0A6I8QZS4
uniprot id: Q28CQ7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates in stable binding to heterochromatin (By similarity).
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes (By similarity).
messages: In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
messages: Nucleus
messages: centromere

8364:camta1
gene id: 8364:camta1
uniprot id: A0A6I8QFA6
uniprot id: A0A6I8SXR7
uniprot id: A0A8J1JTK5
uniprot id: A0A8J1JTK6
uniprot id: A0A8J1JTK7
uniprot id: A0A8J1JTL0
uniprot id: A0A8J1JTL2
uniprot id: A0A8J1JXD3
uniprot id: A0A8J1JXE0
uniprot id: A0A8J1JXE6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CAMTA family.
messages: May interact with calmodulin.
messages: Nucleus

8364:LOC108646289
gene id: 8364:LOC108646289
uniprot id: B5DDY3
uniprot id: Q28DR4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by pak2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

8364:fubp1
gene id: 8364:fubp1
uniprot id: A0A8J0SB87
uniprot id: F7AF96
names: Subcellular Location Annotation
messages: Nucleus

8364:apoh
gene id: 8364:apoh
uniprot id: A0A803J8P5
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:aff4
gene id: 8364:aff4
uniprot id: A0A8J1J9X7
uniprot id: F7B353
names: Similarity
messages: Belongs to the AF4 family.

8364:LOC100487578
gene id: 8364:LOC100487578
uniprot id: A0A803K090
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8364:litaf
gene id: 8364:litaf
uniprot id: Q6P828
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Cell membrane
messages: Cytoplasm
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Nucleus
messages: Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role in the nucleus in regulating the expression of numerous cytokines.
messages: The LITAF domain is stabilized by a bound zinc ion. The LITAF domain contains an amphipathic helix that mediates interaction with lipid membranes.

8364:alyref
gene id: 8364:alyref
uniprot id: Q28FB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation.
messages: Belongs to the ALYREF family.
messages: Component of the transcription/export (TREX) complex; TREX seems to have a dynamic structure involving ATP-dependent remodeling (By similarity).
messages: Cytoplasm
messages: Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm. Involved in the nuclear export of intronless mRNA. Involved in transcription elongation and genome stability (By similarity).
messages: Nucleus
messages: Nucleus speckle

8364:astl2f
gene id: 8364:astl2f
uniprot id: A0A8J0QKZ0
uniprot id: A0A8J0SL91
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:ednrb
gene id: 8364:ednrb
uniprot id: A0A8J0SG48
uniprot id: F6RQM0
uniprot id: Q0P4U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:ppp1r13b
gene id: 8364:ppp1r13b
uniprot id: A0A6I8PXJ0
uniprot id: A0A6I8T0N0
uniprot id: A0A8J0R722
uniprot id: A0A8J0STQ7
uniprot id: A0A8J0SWS5
uniprot id: A0A8J0T5I6
uniprot id: A0A8J1IP14
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100489903
gene id: 8364:LOC100489903
uniprot id: A0A6I8SJ58
uniprot id: A0A8J0T3B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity.
messages: Membrane

8364:chst14
gene id: 8364:chst14
uniprot id: A0A803KBU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:LOC100490822
gene id: 8364:LOC100490822
uniprot id: A0A8J1IPV0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:pdk1
gene id: 8364:pdk1
uniprot id: F6QN91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

8364:ovch2
gene id: 8364:ovch2
uniprot id: A0A8J1JER3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:spred1
gene id: 8364:spred1
uniprot id: Q66JG9
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cell membrane
messages: Palmitoylated by ZDHHC17/HIP14.
messages: Phosphorylated on tyrosine.
messages: Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.
messages: Ubiquitinated.

8364:nme6
gene id: 8364:nme6
uniprot id: B3DL53
names: Function
names: Similarity
messages: Belongs to the NDK family.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

8364:hoxc12
gene id: 8364:hoxc12
uniprot id: F7BEI0
names: Subcellular Location Annotation
messages: Nucleus

8364:t2r45
gene id: 8364:t2r45
uniprot id: Q2AB42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:t2r2
gene id: 8364:t2r2
uniprot id: Q2AB79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:l3mbtl2
gene id: 8364:l3mbtl2
uniprot id: A0A6I8R0A2
uniprot id: A0A8J0SJA3
uniprot id: F7DX49
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus
messages: Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.
messages: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.

8364:fitm1
gene id: 8364:fitm1
uniprot id: A0A6I8SGI6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIT family. FIT1 subfamily.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol.
messages: Membrane

8364:shmt2
gene id: 8364:shmt2
uniprot id: A0A8J0SD81
uniprot id: Q68EQ3
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

8364:ripply2.1
gene id: 8364:ripply2.1
uniprot id: A0A6I8SCR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

8364:mpv17l2
gene id: 8364:mpv17l2
uniprot id: A0A8J0SGD0
uniprot id: A0A8J1JAK7
uniprot id: Q6DIY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Interacts with the large mitochondrial ribosomal subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Required for the assembly and stability of the mitochondrial ribosome (By similarity). Is a positive regulator of mitochondrial protein synthesis (By similarity).

8364:gja9
gene id: 8364:gja9
uniprot id: A0A6I8R8Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8364:LOC105946401
gene id: 8364:LOC105946401
uniprot id: A0A8J1IZJ3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:tmco1
gene id: 8364:tmco1
uniprot id: A0A803KHW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMCO1 family.
messages: Calcium-selective channel required to prevent calcium stores from overfilling.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:flvcr1
gene id: 8364:flvcr1
uniprot id: A0A6I8S2X2
names: Subcellular Location Annotation
messages: Membrane

8364:psmd13
gene id: 8364:psmd13
uniprot id: F6VLC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S11 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

8364:slc7a1
gene id: 8364:slc7a1
uniprot id: A0A6I8SN36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

8364:agtr2
gene id: 8364:agtr2
uniprot id: F6Z3M6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MTUS1.
messages: Membrane

8364:kbtbd8
gene id: 8364:kbtbd8
uniprot id: A0A5S6L6J5
uniprot id: A0A803JQD8
uniprot id: A0A8J0SCR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KBTBD8 family.
messages: Golgi apparatus
messages: spindle

8364:ap1g1
gene id: 8364:ap1g1
uniprot id: A0A6I8QYC5
uniprot id: A0A6I8SWT5
uniprot id: A0A8J0QYE4
uniprot id: A0A8J0STD6
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

8364:prok2
gene id: 8364:prok2
uniprot id: A0A8J0QUZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

8364:rplp2
gene id: 8364:rplp2
uniprot id: Q28IH1
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

8364:impa2
gene id: 8364:impa2
uniprot id: A0A8J0QNR5
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

8364:rps3
gene id: 8364:rps3
uniprot id: Q6P8G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: spindle

8364:ubald2
gene id: 8364:ubald2
uniprot id: Q5XGE4
names: Similarity
messages: Belongs to the UBALD family.

8364:sv2b
gene id: 8364:sv2b
uniprot id: A0A6I8QZ90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

8364:dnmt3a
gene id: 8364:dnmt3a
uniprot id: A0A1B8Y2T5
uniprot id: A0A8J0QYX3
uniprot id: A0A8J0R7R3
uniprot id: A0A8J0R869
uniprot id: A0A8J1JMC5
uniprot id: F7BU15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Nucleus

8364:ano1
gene id: 8364:ano1
uniprot id: B3DLV2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:soat1
gene id: 8364:soat1
uniprot id: A0A6I8QUE6
uniprot id: B1H100
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:tmc1
gene id: 8364:tmc1
uniprot id: A0A8J0QRF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

8364:dhodh
gene id: 8364:dhodh
uniprot id: Q5BKN2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.
messages: Mitochondrion inner membrane

8364:tnpo2
gene id: 8364:tnpo2
uniprot id: A0A1B8Y405
names: Subcellular Location Annotation
messages: Cytoplasm

8364:htr1d
gene id: 8364:htr1d
uniprot id: A0A803JNZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:taf9b
gene id: 8364:taf9b
uniprot id: F6UGW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

8364:adprm
gene id: 8364:adprm
uniprot id: Q66JJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ADPRibase-Mn family.
messages: Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose.
messages: Monomer.

8364:usp2
gene id: 8364:usp2
uniprot id: A0A6I8SRE1
uniprot id: B4F6P0
names: Similarity
messages: Belongs to the peptidase C19 family.

8364:hoxc3
gene id: 8364:hoxc3
uniprot id: F7BJA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

8364:gins1
gene id: 8364:gins1
uniprot id: B5DES7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.

8364:nlgn1
gene id: 8364:nlgn1
uniprot id: A0A6I8QK87
uniprot id: A0A6I8RTS2
uniprot id: D2X2K4
uniprot id: F6WUA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

8364:LOC100493583
gene id: 8364:LOC100493583
uniprot id: A0A6I8QM82
uniprot id: A0A8J0SH15
names: Subcellular Location Annotation
messages: Membrane

8364:cyp21a2.1
gene id: 8364:cyp21a2.1
uniprot id: A0A8J0QV06
uniprot id: A0A8J0SXK9
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:rell1
gene id: 8364:rell1
uniprot id: A9JSN6
names: Similarity
messages: Belongs to the RELT family.

8364:otp
gene id: 8364:otp
uniprot id: A0A8J0QUN7
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100494075
gene id: 8364:LOC100494075
uniprot id: A0A8J0QVT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100494741
gene id: 8364:LOC100494741
uniprot id: A0A8J0QME1
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:pou3f2
gene id: 8364:pou3f2
uniprot id: I0ISM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus

8364:LOC100489121
gene id: 8364:LOC100489121
uniprot id: A0A8J1IZZ8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natural cytotoxicity receptor (NCR) family.
messages: Cell membrane
messages: Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6.
messages: Membrane

8364:LOC100489821
gene id: 8364:LOC100489821
uniprot id: A0A8J1J983
names: Similarity
messages: Belongs to the ARTD/PARP family.

8364:t2r25
gene id: 8364:t2r25
uniprot id: Q2AB58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:MGC108147
gene id: 8364:MGC108147
uniprot id: A0A8J0PH61
uniprot id: A0A8J0SVZ9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC105946911
gene id: 8364:LOC105946911
uniprot id: A0A8J1JAG3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:mdh1
gene id: 8364:mdh1
uniprot id: Q6DIY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS).
messages: Homodimer.
messages: cytosol

8364:incenp
gene id: 8364:incenp
uniprot id: A0A5S6KYG6
uniprot id: Q0IHP2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the INCENP family.
messages: Chromosome
messages: Component of the CPC at least composed of survivin/birc5, incenp, cdca8/borealin and/or cdca9/dasra-A, and aurkb/aurora-B. Interacts (via C-terminus) with aurkb (via N-terminus and kinase domain). Interacts (via N-terminus) with birc5.1, birc5.2, cdca8 and cdca9. Interacts with mtus1 (By similarity).
messages: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with aurkb/aurora-B, the N-terminus associated with cdca8/borealin and/or cdca9/dasra-A tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs aurkb/aurora-B toward substrates near microtubules. Activates aurkb.
messages: Midbody
messages: Nucleus
messages: Originally predicted to contain a coiled coil domain but shown to contain a stable SAH domain instead.
messages: The IN box mediates interaction with aurkb/aurora-B.
messages: The SAH (single alpha-helix) region is characterized by a high content of charged residues which are predicted to stabilize the alpha-helical structure by ionic bonds. It can refold after extension suggesting an in vivo force-dependent function. The isolated SAH domain is monomeric.
messages: centromere
messages: kinetochore
messages: spindle

8364:lztfl1
gene id: 8364:lztfl1
uniprot id: A9ULJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTFL1 family.
messages: Cytoplasm
messages: Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
messages: Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.

8364:LOC116407071
gene id: 8364:LOC116407071
uniprot id: A0A8J1IRP0
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100494756
gene id: 8364:LOC100494756
uniprot id: A0A8J0QTG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100495295
gene id: 8364:LOC100495295
uniprot id: A0A8J0QK88
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:uts2rl3
gene id: 8364:uts2rl3
uniprot id: A0A8J0R573
uniprot id: F6UK24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.
messages: Membrane

8364:anapc11
gene id: 8364:anapc11
uniprot id: Q5RJJ5
names: Similarity
messages: Belongs to the RING-box family.

8364:heatr5b
gene id: 8364:heatr5b
uniprot id: A0A8J1JJR9
uniprot id: A1A5F2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEATR5 family.
messages: Component of clathrin-coated vesicles (By similarity). Plays a role in protein trafficking (By similarity).
messages: clathrin-coated vesicle

8364:LOC100497124
gene id: 8364:LOC100497124
uniprot id: F6TL36
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:LOC100485343
gene id: 8364:LOC100485343
uniprot id: A0A8J1JHX0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

8364:ptpa
gene id: 8364:ptpa
uniprot id: A0A6I8RJ60
uniprot id: A0A8J0QZ06
uniprot id: A0A8J0SWF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

8364:ndst4
gene id: 8364:ndst4
uniprot id: A0A7D9NL22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

8364:LOC100485636
gene id: 8364:LOC100485636
uniprot id: F6ZGF2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homomer. Forms heteromers with ACKR4.
messages: Membrane

8364:LOC101732890
gene id: 8364:LOC101732890
uniprot id: A0A8J1IY37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:gab2
gene id: 8364:gab2
uniprot id: A0A8J0R1Y0
uniprot id: F6ZBI8
names: Similarity
messages: Belongs to the GAB family.

8364:kcnh6
gene id: 8364:kcnh6
uniprot id: A0A803JQ59
uniprot id: A0A803JQ84
uniprot id: A0A8J1JNY0
uniprot id: A0A8J1JNZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily.
messages: Membrane

8364:LOC105946963
gene id: 8364:LOC105946963
uniprot id: A0A8J1J8F5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:gsn
gene id: 8364:gsn
uniprot id: A0A6I8QYJ9
uniprot id: A0A8J1ILH2
uniprot id: A0A8J1IP84
uniprot id: Q28DN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
messages: cytoskeleton

8364:pik3c3
gene id: 8364:pik3c3
uniprot id: A0A8J1J1B5
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

8364:t2r49
gene id: 8364:t2r49
uniprot id: Q2AB38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:foxo4
gene id: 8364:foxo4
uniprot id: A0A6I8SUH1
uniprot id: F6RTU2
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC101734900
gene id: 8364:LOC101734900
uniprot id: F6XTM2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:znf503
gene id: 8364:znf503
uniprot id: Q05AQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Elbow/Noc family.
messages: May function as a transcriptional repressor.
messages: Nucleus

8364:slc6a5
gene id: 8364:slc6a5
uniprot id: A0A7D9NK84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8364:LOC100145000
gene id: 8364:LOC100145000
uniprot id: A0A6I8PV97
uniprot id: B0BM98
names: Similarity
messages: Belongs to the IUNH family.

8364:pdia4
gene id: 8364:pdia4
uniprot id: A0A6I8ST10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

8364:vps29
gene id: 8364:vps29
uniprot id: A0A6I8PY61
uniprot id: Q6DEU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity). Acts also as component of the retriever complex. The retriever complex is an heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrins. In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (By similarity).
messages: Belongs to the VPS29 family.
messages: Component of the heterotrimeric retromer cargo-selective complex (CSC) which is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants (By similarity). Component of the heterotrimeric retriever complex (By similarity).
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

8364:mrps31
gene id: 8364:mrps31
uniprot id: A0A8J0R1P5
uniprot id: Q0V9E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS31 family.
messages: Mitochondrion

8364:LOC101734907
gene id: 8364:LOC101734907
uniprot id: A0A8J1IUN1
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:pcdhga11
gene id: 8364:pcdhga11
uniprot id: A0A6I8QF12
uniprot id: A0A6I8SRQ4
uniprot id: A0A803JVN0
uniprot id: A0A8J0S9S4
uniprot id: A0A8J0SFX6
uniprot id: A0A8J0SFY1
uniprot id: A0A8J0SHM3
uniprot id: A0A8J0SHM9
uniprot id: A0A8J0SHN2
uniprot id: A0A8J0SIU9
uniprot id: A0A8J0SIV3
uniprot id: A0A8J0SIV4
uniprot id: A0A8J0SIV7
uniprot id: A0A8J0SS55
uniprot id: A0A8J0T1L7
uniprot id: A0A8J1J7P1
uniprot id: A0A8J1J7P3
uniprot id: A0A8J1J7P6
uniprot id: A0A8J1J7P9
uniprot id: A0A8J1J7Q0
uniprot id: A0A8J1J7Q1
uniprot id: A0A8J1J7Q5
uniprot id: A0A8J1J7Q7
uniprot id: A0A8J1J7Q9
uniprot id: A0A8J1J7R1
uniprot id: A0A8J1J7R2
uniprot id: A0A8J1J7R6
uniprot id: A0A8J1J7S1
uniprot id: A0A8J1JA48
uniprot id: A0A8J1JA52
uniprot id: A0A8J1JA57
uniprot id: A0A8J1JA63
uniprot id: A0A8J1JB56
uniprot id: A0A8J1JB62
uniprot id: A0A8J1JB77
uniprot id: Q0V9M2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

8364:adamts16
gene id: 8364:adamts16
uniprot id: A0A6I8T1W7
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:rora
gene id: 8364:rora
uniprot id: A0A6I8Q1U3
uniprot id: A0A8J0SU43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

8364:ccser2
gene id: 8364:ccser2
uniprot id: A0A6I8QLQ3
uniprot id: A0A6I8S5D8
uniprot id: A0A8J0QTG7
uniprot id: A0A8J0SR86
uniprot id: A0A8J0SU79
names: Similarity
messages: Belongs to the CCSER family.

8364:ccnj
gene id: 8364:ccnj
uniprot id: A0A803J883
names: Similarity
messages: Belongs to the cyclin family.

8364:LOC100495429
gene id: 8364:LOC100495429
uniprot id: A0A803KLB9
uniprot id: A0A8J0T5Y1
uniprot id: F7DW62
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

8364:slc35c2
gene id: 8364:slc35c2
uniprot id: Q5FW18
names: Subcellular Location Annotation
messages: Membrane

8364:LOC101731580
gene id: 8364:LOC101731580
uniprot id: A0A8J1IX54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

8364:fzd6
gene id: 8364:fzd6
uniprot id: A0A8J0QEP6
uniprot id: F6SSF6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:slc1a1
gene id: 8364:slc1a1
uniprot id: A0A6I8QSR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

8364:dstn
gene id: 8364:dstn
uniprot id: A0A803JPG7
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

8364:cyp1d1
gene id: 8364:cyp1d1
uniprot id: A0A6I8Q0C1
uniprot id: A0A803K2E8
uniprot id: B1H1C5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

8364:adra2c
gene id: 8364:adra2c
uniprot id: A0A803KIZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:lix1
gene id: 8364:lix1
uniprot id: A0A8J0QNE6
names: Similarity
messages: Belongs to the LIX1 family.

8364:atp5f1c
gene id: 8364:atp5f1c
uniprot id: A0A6I8PXM9
uniprot id: A0A8J0PHQ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

8364:atp4b
gene id: 8364:atp4b
uniprot id: F6T938
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

8364:proz
gene id: 8364:proz
uniprot id: A0A6I8PTX3
uniprot id: B1H1C8
uniprot id: Q5M8E7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:nr3c1
gene id: 8364:nr3c1
uniprot id: Q28E31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Mitochondrion
messages: Nucleus
messages: centrosome
messages: spindle

8364:ccni2
gene id: 8364:ccni2
uniprot id: A0A8J1J6C6
uniprot id: A4IIX7
names: Similarity
messages: Belongs to the cyclin family.

8364:mal2
gene id: 8364:mal2
uniprot id: A9JTW0
names: Subcellular Location Annotation
messages: Membrane

8364:nfu1
gene id: 8364:nfu1
uniprot id: A0A803KHA8
uniprot id: F6QZX6
names: Similarity
messages: Belongs to the NifU family.

8364:hmgb2
gene id: 8364:hmgb2
uniprot id: A0A803KH06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

8364:pskh2
gene id: 8364:pskh2
uniprot id: F6RNG6
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:tcp1
gene id: 8364:tcp1
uniprot id: A0A6I8T009
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

8364:masp2
gene id: 8364:masp2
uniprot id: A0A803KHT1
uniprot id: A0A8J0SSA2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC116410967
gene id: 8364:LOC116410967
uniprot id: A0A8J1JPM7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:ampd3
gene id: 8364:ampd3
uniprot id: A0A6I8S4X3
uniprot id: Q561K1
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

8364:MGC146443
gene id: 8364:MGC146443
uniprot id: Q0V9P2
names: Similarity
messages: Belongs to the RNase H family.

8364:LOC100494953
gene id: 8364:LOC100494953
uniprot id: A0A8J1JN79
uniprot id: A0A8J1JQN9
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:lta
gene id: 8364:lta
uniprot id: A0A803KAF3
uniprot id: A9JPI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Membrane

8364:stim1
gene id: 8364:stim1
uniprot id: A0A6I8T1U1
uniprot id: A0A8J1J1F4
uniprot id: A0A8J1J1F6
uniprot id: A0A8J1J1G1
uniprot id: A0A8J1J1G2
uniprot id: A0A8J1J4V0
uniprot id: Q6NZH3
names: Subcellular Location Annotation
messages: Membrane

8364:lancl1
gene id: 8364:lancl1
uniprot id: Q28ES9
names: Similarity
messages: Belongs to the LanC-like protein family.

8364:kcnh2
gene id: 8364:kcnh2
uniprot id: A0A6I8SFD4
uniprot id: A0A8J0SX92
names: Subcellular Location Annotation
messages: Membrane

8364:slc18a1
gene id: 8364:slc18a1
uniprot id: A0A8J0S9N1
uniprot id: Q5BL82
names: Subcellular Location Annotation
messages: Membrane

8364:ibsp
gene id: 8364:ibsp
uniprot id: B9UIT8
names: Function
names: Subcellular Location Annotation
messages: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
messages: Secreted

8364:myadm
gene id: 8364:myadm
uniprot id: Q6DFR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL family.
messages: Membrane

8364:fmc1
gene id: 8364:fmc1
uniprot id: A9UL63
uniprot id: B7ZUM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMC1 family.
messages: Mitochondrion
messages: Plays a role in the assembly/stability of the mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V).

8364:bcl9l
gene id: 8364:bcl9l
uniprot id: A0A6I8SYY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

8364:cdkn1b
gene id: 8364:cdkn1b
uniprot id: A0A803JZK6
names: Similarity
messages: Belongs to the CDI family.

8364:LOC100497863
gene id: 8364:LOC100497863
uniprot id: A0A8J1IR08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

8364:LOC101734961
gene id: 8364:LOC101734961
uniprot id: A0A8J1JTN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8364:cdh6
gene id: 8364:cdh6
uniprot id: A0A6I8R610
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane

8364:ero1a
gene id: 8364:ero1a
uniprot id: A0A8J0SVG6
uniprot id: B1H1F9
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane
messages: Enzyme activity is tightly regulated to prevent the accumulation of reactive oxygen species in the endoplasmic reticulum. Reversibly down-regulated by the formation of disulfide bonds between the active site Cys-99 and Cys-138, and between Cys-104 and Cys-109. Glutathione may be required to regulate its activity in the endoplasmic reticulum (By similarity).
messages: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the folding of immunoglobulins (By similarity).
messages: Predominantly monomer. May function both as a monomer and a homodimer (By similarity).
messages: The Cys-99/Cys-104 and Cys-401/Cys-404 disulfide bonds constitute the redox-active center. The Cys-99/Cys-104 disulfide bond may accept electron from protein disulfide isomerase (PDI) and funnel them to the active site disulfide Cys-401/Cys-404 (By similarity).

8364:gdf10
gene id: 8364:gdf10
uniprot id: A0A6I8R264
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer.
messages: Secreted

8364:fat2
gene id: 8364:fat2
uniprot id: A0A8J0T1T3
uniprot id: A0A8J0T325
uniprot id: A0A8J1J9M2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:kif23
gene id: 8364:kif23
uniprot id: A0A6I8R2R4
uniprot id: A0A6I8SQZ4
uniprot id: A0A8J0S9C6
uniprot id: A0A8J0S9D1
uniprot id: A0A8J0SFC9
uniprot id: A0A8J0SH28
uniprot id: F6U8S9
uniprot id: F6U8W5
uniprot id: Q5XGE1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8364:zdhhc1
gene id: 8364:zdhhc1
uniprot id: A0A8J0SLC0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8364:map3k7
gene id: 8364:map3k7
uniprot id: A0A6I8QTD1
uniprot id: A0A8J0SN69
uniprot id: A0A8J0STN1
uniprot id: A4IIZ7
uniprot id: F6U298
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

8364:hspa1a
gene id: 8364:hspa1a
uniprot id: A0A6I8SRC1
names: Similarity
messages: Belongs to the heat shock protein 70 family.

8364:aldoa
gene id: 8364:aldoa
uniprot id: Q6GL64
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

8364:hgf
gene id: 8364:hgf
uniprot id: A0A6I8R680
uniprot id: A0A8J1JAI7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

8364:tcn2
gene id: 8364:tcn2
uniprot id: A9ULJ2
uniprot id: Q5M8G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

8364:raly
gene id: 8364:raly
uniprot id: A0A8J0QMH3
uniprot id: F6RL63
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

8364:psmd3
gene id: 8364:psmd3
uniprot id: A0A1B8Y9B4
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

8364:hoxa1
gene id: 8364:hoxa1
uniprot id: F7D5S1
names: Subcellular Location Annotation
messages: Nucleus

8364:phospho2
gene id: 8364:phospho2
uniprot id: Q66KD6
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.
messages: Probable phosphatase.

8364:spcs1
gene id: 8364:spcs1
uniprot id: A9ULB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:slc4a3
gene id: 8364:slc4a3
uniprot id: A0A1B8Y266
uniprot id: A0A7D9NL51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Membrane

8364:LOC100497738
gene id: 8364:LOC100497738
uniprot id: A0A8J0QUN1
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

8364:LOC100216007
gene id: 8364:LOC100216007
uniprot id: B0JZZ3
names: Similarity
messages: Belongs to the globin family.

8364:dlgap4
gene id: 8364:dlgap4
uniprot id: A0A803KKK4
uniprot id: A0A8J0SPQ2
uniprot id: F7CFC5
names: Similarity
messages: Belongs to the SAPAP family.

8364:gatm
gene id: 8364:gatm
uniprot id: Q6P832
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amidinotransferase family.
messages: Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development (By similarity).
messages: Homodimer.
messages: Mitochondrion inner membrane

8364:ctla4
gene id: 8364:ctla4
uniprot id: A0A6I8RD47
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
messages: Membrane

8364:id4
gene id: 8364:id4
uniprot id: Q6GL62
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer with other HLH proteins.
messages: Nucleus
messages: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Inhibits the activity of both neurogenic (neurog1/neurogenin, neurod1/neuroD) and myogenic (myod1/myoD) bHLH factors (By similarity).

8364:scoc
gene id: 8364:scoc
uniprot id: A0A6I8RJR4
uniprot id: A0A8J0SAX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCOC family.
messages: Positive regulator of amino acid starvation-induced autophagy.
messages: trans-Golgi network

8364:nop16
gene id: 8364:nop16
uniprot id: Q6NVB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP16 family.
messages: nucleolus

8364:nt5c2
gene id: 8364:nt5c2
uniprot id: A0A6I8R038
uniprot id: A0A6I8SJB3
uniprot id: A0A8J0SSD4
uniprot id: Q5EBF1
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by various compounds including ATP, 2,3-BPG/2,3-Bisphosphoglyceric acid and Ap4A/P1,P4-bis(5'-adenosyl) tetraphosphate. Binding of an allosteric activator is a prerequisiste to magnesium and substrate binding. Inhibited by inorganic phosphate.
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates. In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine. Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP. Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency. Through these activities regulates the purine nucleoside/nucleotide pools within the cell.
messages: Homotetramer.
messages: cytosol

8364:nup188
gene id: 8364:nup188
uniprot id: A0A5S6M1K6
uniprot id: A0A8J0SS94
uniprot id: F6WXT2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nup188 family.
messages: Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Required for proper protein transport into the nucleus.
messages: Expressed in the developing kidney at stages 26-29 and 33-36, and in the branchial arches at stage 33-36.
messages: Morpholino knockdown of the protein causes abnormal heart and gut looping.
messages: Part of the nuclear pore complex (NPC).
messages: nuclear pore complex

8364:fabp7
gene id: 8364:fabp7
uniprot id: Q28CE2
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

8364:LOC100497498
gene id: 8364:LOC100497498
uniprot id: A0A6I8RGR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: lamellipodium

8364:cyp2a6.7
gene id: 8364:cyp2a6.7
uniprot id: A0A6I8PP89
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:slc6a19
gene id: 8364:slc6a19
uniprot id: F6WWA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8364:LOC105946966
gene id: 8364:LOC105946966
uniprot id: A0A8J0SAP0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC100488188
gene id: 8364:LOC100488188
uniprot id: A0A803JIW0
uniprot id: A0A8J1J4N2
names: Similarity
messages: Belongs to the dynein heavy chain family.

8364:l3mbtl3
gene id: 8364:l3mbtl3
uniprot id: A0A6I8RCU5
uniprot id: A0A8J0QVW4
names: Subcellular Location Annotation
messages: Nucleus

8364:fnip1
gene id: 8364:fnip1
uniprot id: A0A6I8R4V3
uniprot id: A0A8J0R2M1
uniprot id: A0A8J1J9W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

8364:atl1
gene id: 8364:atl1
uniprot id: A0A6I8Q8L1
uniprot id: A0A6I8SRS4
uniprot id: A0A8J1IPG1
uniprot id: Q0VFK0
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8364:slc29a2
gene id: 8364:slc29a2
uniprot id: A0A8J0SIK5
uniprot id: A0A8J1JDH4
uniprot id: Q28F84
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Lateral cell membrane
messages: Membrane

8364:LOC101731067
gene id: 8364:LOC101731067
uniprot id: A0A8J0R447
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:LOC100485144
gene id: 8364:LOC100485144
uniprot id: A0A8J1IUI7
names: Similarity
messages: Belongs to the ARTD/PARP family.

8364:mcee
gene id: 8364:mcee
uniprot id: A0A803JSN8
uniprot id: F6UJX4
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

8364:LOC100491305
gene id: 8364:LOC100491305
uniprot id: A0A8J1IVP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:casp8
gene id: 8364:casp8
uniprot id: A0A6I8Q0P2
names: Similarity
messages: Belongs to the peptidase C14A family.

8364:qtrt2
gene id: 8364:qtrt2
uniprot id: A0A8J1J1X2
uniprot id: Q28DX0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Heterodimer of a catalytic subunit qtrt1 and an accessory subunit qtrt2.
messages: Mitochondrion outer membrane
messages: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

8364:usp37
gene id: 8364:usp37
uniprot id: A0A6I8Q2J8
uniprot id: A0A6I8SW45
uniprot id: F7DC76
names: Similarity
messages: Belongs to the peptidase C19 family.

8364:lactb2
gene id: 8364:lactb2
uniprot id: A0A8J1JN59
uniprot id: Q0V9A9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.
messages: Mitochondrion matrix

8364:pisd
gene id: 8364:pisd
uniprot id: A0A6I8QAU2
uniprot id: A0A8J0SGZ0
uniprot id: A0A8J0SNX0
uniprot id: F6VFD4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

8364:trmt5
gene id: 8364:trmt5
uniprot id: A0A803JSY0
uniprot id: A0A803K9K6
uniprot id: A0A8J1IM73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM5 / TYW2 family.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

8364:gabpa
gene id: 8364:gabpa
uniprot id: A0A803KI95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8364:cacna1f
gene id: 8364:cacna1f
uniprot id: A0A8J1IRF3
uniprot id: A0A8J1IS53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

8364:foxc1
gene id: 8364:foxc1
uniprot id: Q68F77
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Required for cell viability and resistance to oxidative stress in the eye. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals. Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion. Involved in chemokine-induced endothelial cell migration. Plays a role in epidermal keratinocyte terminal differentiation. Essential developmental transcriptional factor required for mesoderm-derived tissues formation, such as the somites, skin, bone and cartilage. Plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Plays a role at the gastrula stage for expression of several mesodermal and endodermal genes. At the late neurula stage, regulates expression of adhesion genes to maintain cell adhesion in the mesodermal germ layer.
messages: Monomer.
messages: Nucleus

8364:fzd5
gene id: 8364:fzd5
uniprot id: A0A803K619
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Membrane

8364:myo1e.1
gene id: 8364:myo1e.1
uniprot id: A0A6I8QHU0
uniprot id: A0A8J1J6N8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:LOC100494194
gene id: 8364:LOC100494194
uniprot id: A0A803K186
names: Similarity
messages: Belongs to the syntaxin family.

8364:t2r3
gene id: 8364:t2r3
uniprot id: Q2AB78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:lvrn
gene id: 8364:lvrn
uniprot id: A0A7D9NLG4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

8364:smim15
gene id: 8364:smim15
uniprot id: A0A803J644
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

8364:ikbkb
gene id: 8364:ikbkb
uniprot id: A0A8J0T101
uniprot id: Q6GL53
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:LOC116408383
gene id: 8364:LOC116408383
uniprot id: A0A8J1IZK1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:cdr2
gene id: 8364:cdr2
uniprot id: F6R4S1
names: Similarity
messages: Belongs to the CDR2 family.

8364:elp1
gene id: 8364:elp1
uniprot id: A0A6I8QKB3
uniprot id: A0A8J0SEI4
uniprot id: B2RY98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP1/IKA1 family.
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
messages: Cytoplasm
messages: Nucleus

8364:osmr
gene id: 8364:osmr
uniprot id: A0A803J8Y0
uniprot id: A0A803JIL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

8364:LOC105945589
gene id: 8364:LOC105945589
uniprot id: A0A8J0T573
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:slc15a4
gene id: 8364:slc15a4
uniprot id: A0A7D9NK03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

8364:ddx49
gene id: 8364:ddx49
uniprot id: A0A6I8RGE1
uniprot id: A0A8J0SF09
uniprot id: Q6P1S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family.
messages: Cytoplasm
messages: Nucleus

8364:snx11
gene id: 8364:snx11
uniprot id: B0JZ87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

8364:p2rx1
gene id: 8364:p2rx1
uniprot id: A0A6I8RW96
uniprot id: A0A8J0QLV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

8364:impad1
gene id: 8364:impad1
uniprot id: Q28CL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily.
messages: Membrane

8364:eef1b2
gene id: 8364:eef1b2
uniprot id: Q6DET9
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.
messages: Phosphorylation affects the GDP/GTP exchange rate.

8364:fam135b
gene id: 8364:fam135b
uniprot id: A0A8J0T563
names: Similarity
messages: Belongs to the FAM135 family.

8364:atp8b1
gene id: 8364:atp8b1
uniprot id: Q5BL50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (By similarity). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May also participate in the establishment of the canalicular membrane integrity by ensuring asymmetric distribution of phospholipids in the canicular membrane (By similarity).
messages: Cell membrane
messages: Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit. The flippase ATP8B1:TMEM30A complex can form an intermediate phosphoenzyme in vitro. Also interacts with beta subunit TMEM30B.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: stereocilium

8364:rpl37a
gene id: 8364:rpl37a
uniprot id: Q6AZL0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

8364:chrnb2
gene id: 8364:chrnb2
uniprot id: A4IIS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:foxd4l1.2
gene id: 8364:foxd4l1.2
uniprot id: F6XIK9
names: Subcellular Location Annotation
messages: Nucleus

8364:ajap1
gene id: 8364:ajap1
uniprot id: A0A803JH80
uniprot id: A0A803JVR9
uniprot id: Q0IIY7
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: May play a role in cell adhesion and cell migration.
messages: Membrane
messages: adherens junction

8364:gpat4
gene id: 8364:gpat4
uniprot id: F6ZFQ7
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

8364:trappc3
gene id: 8364:trappc3
uniprot id: Q5BKN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

8364:th2
gene id: 8364:th2
uniprot id: A0A803J5C5
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

8364:LOC101732756
gene id: 8364:LOC101732756
uniprot id: A0A803KAT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Vesicular transporter family.
messages: Membrane

8364:LOC105946953
gene id: 8364:LOC105946953
uniprot id: A0A8J1J8E3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:itih6
gene id: 8364:itih6
uniprot id: A0A6I8S7D8
uniprot id: A0A6I8SLF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

8364:ndrg4
gene id: 8364:ndrg4
uniprot id: A0A6I8R1L8
uniprot id: A0A6I8SGK4
uniprot id: A0A6I8SU95
uniprot id: A0A8J0SI58
uniprot id: A0A8J0SKY0
uniprot id: A0A8J0SL20
uniprot id: Q6DIX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: Contributes to the maintenance of intracerebral BDNF levels within the normal range. May enhance growth factor-induced ERK1 and ERK2 phosphorylation. May attenuate growth factor-promoted ELK1 phosphorylation in a microtubule-dependent manner (By similarity).
messages: cytosol

8364:LOC100494566
gene id: 8364:LOC100494566
uniprot id: A0A6I8Q8V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:adam33
gene id: 8364:adam33
uniprot id: F6XAI3
uniprot id: Q27JK6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:hba4
gene id: 8364:hba4
uniprot id: Q38IV9
names: Similarity
messages: Belongs to the globin family.

8364:foxb1
gene id: 8364:foxb1
uniprot id: F6XYE3
names: Subcellular Location Annotation
messages: Nucleus

8364:slc35a3.1
gene id: 8364:slc35a3.1
uniprot id: F6U699
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8364:KEG17 p05
gene id: 8364:KEG17_p05
uniprot id: Q5G7I2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4L family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane

8364:cdr2l
gene id: 8364:cdr2l
uniprot id: A0A803JSM3
names: Similarity
messages: Belongs to the CDR2 family.

8364:LOC101730405
gene id: 8364:LOC101730405
uniprot id: A0A8J1IPW7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:slc26a6
gene id: 8364:slc26a6
uniprot id: A0A6I8QHX3
uniprot id: Q0VA12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

8364:LOC101730651
gene id: 8364:LOC101730651
uniprot id: A0A803JFB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100498474
gene id: 8364:LOC100498474
uniprot id: A0A8J0T6Y3
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

8364:padi2
gene id: 8364:padi2
uniprot id: A0A7D9NKA7
uniprot id: A4IHA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Cytoplasm

8364:adgrl3
gene id: 8364:adgrl3
uniprot id: A0A803J489
uniprot id: A0A803JEA7
uniprot id: A0A803JXR0
uniprot id: A0A8J1JNM9
uniprot id: A0A8J1JSD2
names: Subcellular Location Annotation
messages: Membrane

8364:LOC116406646
gene id: 8364:LOC116406646
uniprot id: A0A803JCQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

8364:polr2a
gene id: 8364:polr2a
uniprot id: A0A6I8R7L6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

8364:LOC100489930
gene id: 8364:LOC100489930
uniprot id: F6QCC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

8364:LOC100493846
gene id: 8364:LOC100493846
uniprot id: A0A8J0QY97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:arl11l.1
gene id: 8364:arl11l.1
uniprot id: Q6DEQ8
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

8364:fbp1
gene id: 8364:fbp1
uniprot id: Q6P8F7
names: Similarity
messages: Belongs to the FBPase class 1 family.

8364:efnb3
gene id: 8364:efnb3
uniprot id: A8KBG7
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:ldlr
gene id: 8364:ldlr
uniprot id: A0A6I8SL03
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:scfd1
gene id: 8364:scfd1
uniprot id: B4F6K9
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

8364:trim32
gene id: 8364:trim32
uniprot id: F6WAF6
names: Similarity
messages: Belongs to the TRIM/RBCC family.

8364:prpf19
gene id: 8364:prpf19
uniprot id: Q28E36
uniprot id: Q6GLG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Homotetramer.
messages: Lipid droplet
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
messages: nucleoplasm

8364:itk
gene id: 8364:itk
uniprot id: A0A6I8S205
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

8364:anapc2
gene id: 8364:anapc2
uniprot id: F7DMN6
names: Similarity
messages: Belongs to the cullin family.

8364:LOC100170549
gene id: 8364:LOC100170549
uniprot id: A0A6I8PZB9
uniprot id: B3DLV1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

8364:LOC100493455
gene id: 8364:LOC100493455
uniprot id: A0A7D9N0M7
uniprot id: A0A8J1JDI9
names: Similarity
messages: Belongs to the lst-2 family.

8364:smad2
gene id: 8364:smad2
uniprot id: F7AQA6
uniprot id: Q07G47
uniprot id: Q5U4Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

8364:satb1
gene id: 8364:satb1
uniprot id: A0A803KL47
uniprot id: A0A8J1JMA9
uniprot id: F6W9E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

8364:efs
gene id: 8364:efs
uniprot id: A0A6I8RJK2
uniprot id: A0A6I8SWK0
uniprot id: A0A8J0SFT2
uniprot id: A0A8J0SPA2
uniprot id: A0A8J0SQF5
names: Similarity
messages: Belongs to the CAS family.

8364:LOC100488346
gene id: 8364:LOC100488346
uniprot id: A0A6I8R0I3
uniprot id: A0A6I8RM19
uniprot id: A0A6I8RYG4
uniprot id: A0A8J0T1S8
uniprot id: A0A8J1J4C1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:ints8
gene id: 8364:ints8
uniprot id: A4IH10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 8 family.
messages: Nucleus

8364:msx1
gene id: 8364:msx1
uniprot id: Q28CZ3
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC105948066
gene id: 8364:LOC105948066
uniprot id: A0A8J1ILY1
names: Similarity
messages: Belongs to the cyclin family.

8364:dop1b
gene id: 8364:dop1b
uniprot id: G1K3C1
names: Similarity
messages: Belongs to the dopey family.

8364:LOC116406461
gene id: 8364:LOC116406461
uniprot id: A0A803JQI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

8364:slc35d1
gene id: 8364:slc35d1
uniprot id: A0A8J0STF7
uniprot id: A0A8J0T0H0
names: Subcellular Location Annotation
messages: Membrane

8364:mfrp
gene id: 8364:mfrp
uniprot id: A0A6I8Q8S7
uniprot id: A0A8J0T558
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:tmem161b
gene id: 8364:tmem161b
uniprot id: F7CXQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

8364:cfap206
gene id: 8364:cfap206
uniprot id: A0A7D9NJL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP206 family.
messages: cilium axoneme

8364:sftpc
gene id: 8364:sftpc
uniprot id: A0A6I8PPP7
uniprot id: B3DM51
names: Function
names: Subcellular Location Annotation
messages: Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
messages: surface film

8364:med21
gene id: 8364:med21
uniprot id: A0A1B8XTQ2
uniprot id: F6XYZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8364:mapk4
gene id: 8364:mapk4
uniprot id: A0A803J5R0
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

8364:LOC116411020
gene id: 8364:LOC116411020
uniprot id: A0A8J1JNN3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:mrpl54
gene id: 8364:mrpl54
uniprot id: A0A6I8PUR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Mitochondrion

8364:dio1
gene id: 8364:dio1
uniprot id: A0A8J0QER2
uniprot id: A0A8J0QGZ4
names: Function
names: Similarity
messages: Belongs to the iodothyronine deiodinase family.
messages: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).

8364:dtnbp1
gene id: 8364:dtnbp1
uniprot id: A0A6I8QBZ4
uniprot id: A0A8J1JML8
uniprot id: F6VLG3
names: Similarity
messages: Belongs to the dysbindin family.

8364:stim2
gene id: 8364:stim2
uniprot id: A0A803K290
names: Subcellular Location Annotation
messages: Membrane

8364:hnrnpk
gene id: 8364:hnrnpk
uniprot id: A0A8J1J845
uniprot id: Q6P363
names: Subcellular Location Annotation
messages: Cytoplasm
messages: nucleoplasm

8364:celsr1
gene id: 8364:celsr1
uniprot id: A0A6I8RZT9
uniprot id: A0A8J0QIZ2
uniprot id: A0A8J1JDZ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor that may have an important role in cell/cell signaling during nervous system formation.

8364:tspan13
gene id: 8364:tspan13
uniprot id: Q6P4X6
names: Subcellular Location Annotation
messages: Membrane

8364:hdhd2
gene id: 8364:hdhd2
uniprot id: A0A8J1IZB7
uniprot id: B0BMS2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

8364:lage3
gene id: 8364:lage3
uniprot id: A0A6I8QU14
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

8364:yaf2
gene id: 8364:yaf2
uniprot id: Q6PBG0
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100145779
gene id: 8364:LOC100145779
uniprot id: A0A8J1IYE3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

8364:mgme1
gene id: 8364:mgme1
uniprot id: F6SDF8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGME1 family.
messages: Mitochondrion
messages: Single-stranded DNA (ssDNA) metal-dependent exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells (By similarity).
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

8364:LOC108648068
gene id: 8364:LOC108648068
uniprot id: A0A8J1JUV7
names: Subcellular Location Annotation
messages: Membrane

8364:yipf7
gene id: 8364:yipf7
uniprot id: A0A6I8SX36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

8364:pdzk1ip1
gene id: 8364:pdzk1ip1
uniprot id: A0A8J1JG06
names: Subcellular Location Annotation
messages: Membrane

8364:nkx2-1
gene id: 8364:nkx2-1
uniprot id: A0A6I8RFC3
names: Subcellular Location Annotation
messages: Nucleus

8364:agpat5
gene id: 8364:agpat5
uniprot id: Q28E63
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

8364:LOC100495545
gene id: 8364:LOC100495545
uniprot id: A0A8J1J8E6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:tg
gene id: 8364:tg
uniprot id: A0A193GMR8
names: Caution
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC116406815
gene id: 8364:LOC116406815
uniprot id: A0A8J1IPS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:cldn1
gene id: 8364:cldn1
uniprot id: F7DGK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8364:tmem54
gene id: 8364:tmem54
uniprot id: A0A7D9NMG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

8364:acsl5
gene id: 8364:acsl5
uniprot id: Q5XGI9
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.

8364:morn5
gene id: 8364:morn5
uniprot id: Q28FE4
names: Subcellular Location Annotation
messages: flagellum

8364:LOC100493528
gene id: 8364:LOC100493528
uniprot id: A0A8J1ITB1
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8364:xiap
gene id: 8364:xiap
uniprot id: A0A8J1ILI9
uniprot id: A0A8J1ILJ8
uniprot id: Q5BKL8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Degraded in a 2-step mechanism; a caspase-independent first step and a caspase-dependent second step. Stabilized indirectly by MAPK, which acts to delay caspase activation, rather than directly phosphorylating xiap.
messages: Monomer, and homodimer.
messages: Multi-functional protein which regulates not only caspases and apoptosis, but also acts as an E3 ubiquitin-protein ligase mediating ubiquitination and subsequent proteasomal degradation of its target proteins. Acts as a direct caspase inhibitor. E3 ubiquitin-protein ligase that acts as an important regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of ripk2 downstream of NOD1 and NOD2, thereby transforming ripk2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF-kappa-B and MAP kinases signaling (By similarity). A key apoptotic suppressor in eggs. Acts as a positive regulator of Wnt signaling (By similarity).
messages: The BIR and RING-type domains are dispensable for anti-apoptotic function.

8364:tp53bp1
gene id: 8364:tp53bp1
uniprot id: A0A6I8PZS7
uniprot id: A0A6I8QDZ4
uniprot id: A0A8J0R1M2
uniprot id: A0A8J0R2C8
uniprot id: A0A8J0SZI1
names: Subcellular Location Annotation
messages: Nucleus

8364:eme2
gene id: 8364:eme2
uniprot id: Q0IHN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EME1/MMS4 family.
messages: Interacts with mus81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures.
messages: Interacts with mus81.
messages: Nucleus

8364:LOC100490622
gene id: 8364:LOC100490622
uniprot id: A0A8J1J359
names: Similarity
messages: Belongs to the 3-beta-HSD family.

8364:gpr137b
gene id: 8364:gpr137b
uniprot id: A0A8J0PJA0
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

8364:ddt
gene id: 8364:ddt
uniprot id: Q28J83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MIF family.
messages: Cytoplasm
messages: Homotrimer.
messages: Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).

8364:tp53rk
gene id: 8364:tp53rk
uniprot id: F6ZWY1
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

8364:csnk1a1
gene id: 8364:csnk1a1
uniprot id: A0A6I8S330
uniprot id: A0A8J0SF65
uniprot id: A0A8J0SGW3
uniprot id: A0A8J0SI30
uniprot id: Q6NVS7
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC116412041
gene id: 8364:LOC116412041
uniprot id: A0A8J1JTP6
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100498095
gene id: 8364:LOC100498095
uniprot id: A0A8J0QM53
uniprot id: A0A8J0R1I0
uniprot id: A0A8J0R288
uniprot id: A0A8J1JBA9
uniprot id: A0A8J1JDR6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:aqp4
gene id: 8364:aqp4
uniprot id: A0A6I8PZD7
uniprot id: A0A8J0QGX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

8364:ghitm
gene id: 8364:ghitm
uniprot id: A0A8J0PJR2
uniprot id: F6ZFV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

8364:c1r
gene id: 8364:c1r
uniprot id: A0A8J0QSW6
uniprot id: A0A8J0QXY3
uniprot id: A0A8J1JVN6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:abo2
gene id: 8364:abo2
uniprot id: A0A8J0QVZ4
uniprot id: A0A8J1IXW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8364:abcg5
gene id: 8364:abcg5
uniprot id: A0A803KKY9
uniprot id: F7E8L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

8364:ccnb2
gene id: 8364:ccnb2
uniprot id: Q66KA1
names: Similarity
messages: Belongs to the cyclin family.

8364:lmbrd1
gene id: 8364:lmbrd1
uniprot id: Q0VGV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIMR family. LMBRD1 subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors. Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome. Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (By similarity). May play a role in mediating and regulating the internalization of the insulin receptor (By similarity).
messages: Lysosome membrane

8364:LOC100490381
gene id: 8364:LOC100490381
uniprot id: A0A8J0T0Q9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:ndufv2
gene id: 8364:ndufv2
uniprot id: Q28HQ2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.

8364:tns4
gene id: 8364:tns4
uniprot id: A0A803KBS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

8364:nkx3-1
gene id: 8364:nkx3-1
uniprot id: A0A803JP68
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100491571
gene id: 8364:LOC100491571
uniprot id: A0A1B8Y7V0
uniprot id: A0A8J1IQT9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Membrane

8364:map3k15
gene id: 8364:map3k15
uniprot id: A0A8J0SFP8
uniprot id: F7CY76
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

8364:smc5
gene id: 8364:smc5
uniprot id: A0A6I8PRK2
uniprot id: A0A6I8RKA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC5 subfamily.
messages: Nucleus

8364:jmjd1c
gene id: 8364:jmjd1c
uniprot id: A0A6I8QUV0
uniprot id: A0A7D9NLN0
uniprot id: A0A8J1JTJ7
uniprot id: A0A8J1JW00
uniprot id: A0A8J1JXC1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM2 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
messages: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
messages: Nucleus
messages: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.

8364:rab3gap1
gene id: 8364:rab3gap1
uniprot id: A0A6I8T0T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP catalytic subunit family.
messages: Cytoplasm
messages: Endoplasmic reticulum

8364:LOC100493940
gene id: 8364:LOC100493940
uniprot id: A0A803K8D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:dnajc18
gene id: 8364:dnajc18
uniprot id: A4II28
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:myf5
gene id: 8364:myf5
uniprot id: Q8QG50
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

8364:LOC116412177
gene id: 8364:LOC116412177
uniprot id: A0A8J1JYS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:h2bc12
gene id: 8364:h2bc12
uniprot id: Q6AZK7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:slc25a29
gene id: 8364:slc25a29
uniprot id: A0A8J1JXS7
uniprot id: A4IIW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8364:lypla1
gene id: 8364:lypla1
uniprot id: Q6DJB2
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

8364:exosc1
gene id: 8364:exosc1
uniprot id: A0A8J0ST50
uniprot id: F6SHA1
names: Subcellular Location Annotation
messages: Cytoplasm

8364:ckm
gene id: 8364:ckm
uniprot id: Q6P347
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

8364:hba-l4
gene id: 8364:hba-l4
uniprot id: Q38IW2
names: Similarity
messages: Belongs to the globin family.

8364:kcns2
gene id: 8364:kcns2
uniprot id: A0A803JUL8
names: Subcellular Location Annotation
messages: Membrane

8364:LOC108648797
gene id: 8364:LOC108648797
uniprot id: A0A8J0T626
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:bbs2
gene id: 8364:bbs2
uniprot id: A0A6I8RGW5
uniprot id: A0A8J0R2S6
uniprot id: A0A8J0R370
names: Subcellular Location Annotation
messages: centriolar satellite
messages: cilium membrane

8364:slc44a3
gene id: 8364:slc44a3
uniprot id: A0A8J0T0I8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

8364:astl2a
gene id: 8364:astl2a
uniprot id: A0A6I8SEU5
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:lhx2
gene id: 8364:lhx2
uniprot id: A0A1B8YA12
uniprot id: A0A803K5A2
names: Subcellular Location Annotation
messages: Nucleus

8364:ptpru
gene id: 8364:ptpru
uniprot id: A0A6I8Q253
uniprot id: A0A6I8STX0
uniprot id: A0A8J0QT62
uniprot id: A0A8J0SDE3
uniprot id: A0A8J1J4G7
uniprot id: F7EHY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

8364:LOC101733435
gene id: 8364:LOC101733435
uniprot id: A0A1B8Y8S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:nus1
gene id: 8364:nus1
uniprot id: A0A8J0PHK9
names: Similarity
messages: Belongs to the UPP synthase family.

8364:cmtm5
gene id: 8364:cmtm5
uniprot id: A0A6I8Q4K9
names: Subcellular Location Annotation
messages: Membrane

8364:mrap2
gene id: 8364:mrap2
uniprot id: A0A7D9NLE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:uts2rl2
gene id: 8364:uts2rl2
uniprot id: F6Y9G6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.
messages: Membrane

8364:cfap298
gene id: 8364:cfap298
uniprot id: F6ZWN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP298 family.
messages: cilium basal body

8364:xpnpep1
gene id: 8364:xpnpep1
uniprot id: A0A8J1JUH4
uniprot id: A0A8J1JVT4
uniprot id: B1WBJ7
names: Similarity
messages: Belongs to the peptidase M24B family.

8364:traf5
gene id: 8364:traf5
uniprot id: A0A8J1JMU4
uniprot id: F6VTL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

8364:tbce
gene id: 8364:tbce
uniprot id: Q28EJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCE family.
messages: Cytoplasm

8364:fam219b
gene id: 8364:fam219b
uniprot id: A0A8J0SSF6
uniprot id: A0A8J0SZF8
names: Similarity
messages: Belongs to the FAM219 family.

8364:kcnb1
gene id: 8364:kcnb1
uniprot id: A0A803JWF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.
messages: Lateral cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: axon
messages: dendrite
messages: sarcolemma
messages: synaptosome

8364:neu3.1
gene id: 8364:neu3.1
uniprot id: K0PUS8
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

8364:tmem200c
gene id: 8364:tmem200c
uniprot id: A0A6I8PZ32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

8364:msr1
gene id: 8364:msr1
uniprot id: A0A803KE28
names: Subcellular Location Annotation
messages: Membrane

8364:foxe3
gene id: 8364:foxe3
uniprot id: F6PL81
names: Subcellular Location Annotation
messages: Nucleus

8364:or52d1
gene id: 8364:or52d1
uniprot id: F7EIB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:vps13b
gene id: 8364:vps13b
uniprot id: A0A6I8SLD7
uniprot id: F6WB78
names: Similarity
messages: Belongs to the VPS13 family.

8364:has1
gene id: 8364:has1
uniprot id: B1WB39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NodC/HAS family.
messages: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate (By similarity).
messages: Membrane

8364:LOC116412119
gene id: 8364:LOC116412119
uniprot id: A0A8J1JUL2
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:LOC100497718
gene id: 8364:LOC100497718
uniprot id: A0A8J1JL17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP162 family.
messages: centriole

8364:mki67
gene id: 8364:mki67
uniprot id: A0A8J1JV30
uniprot id: A0A8J1JV36
uniprot id: A0A8J1JV37
uniprot id: A0A8J1JV39
uniprot id: A0A8J1JV42
uniprot id: A0A8J1JV43
uniprot id: A0A8J1JV44
uniprot id: A0A8J1JV47
uniprot id: A0A8J1JV48
uniprot id: A0A8J1JXJ5
uniprot id: A0A8J1JZ08
names: Subcellular Location Annotation
messages: Nucleus

8364:rpl14
gene id: 8364:rpl14
uniprot id: Q28CV5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

8364:ttc21b
gene id: 8364:ttc21b
uniprot id: A0A6I8QBQ5
uniprot id: A0A6I8SNT2
names: Similarity
messages: Belongs to the TTC21 family.

8364:entr1
gene id: 8364:entr1
uniprot id: Q28GJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ENTR1 family.
messages: Cytoplasm
messages: Early endosome
messages: Endosome
messages: Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis.
messages: Midbody
messages: Recycling endosome
messages: centrosome
messages: cilium basal body

8364:atl2
gene id: 8364:atl2
uniprot id: A0A8J0QU64
uniprot id: A0A8J0R3R1
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8364:LOC108648861
gene id: 8364:LOC108648861
uniprot id: Q28D68
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:srpx2
gene id: 8364:srpx2
uniprot id: A0A8J1IQD6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:tpmt
gene id: 8364:tpmt
uniprot id: B1H0Z4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.

8364:fam83f
gene id: 8364:fam83f
uniprot id: A0A6I8QNA4
names: Similarity
messages: Belongs to the FAM83 family.

8364:ctu2
gene id: 8364:ctu2
uniprot id: A0A4X2Q847
uniprot id: A0A8J1JDG3
uniprot id: Q28ES8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTU2/NCS2 family.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ctu1/atpbd3 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position.

8364:syngr1
gene id: 8364:syngr1
uniprot id: A8E5R9
uniprot id: Q28CJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

8364:LOC100486623
gene id: 8364:LOC100486623
uniprot id: A0A8J1JVQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:dars2
gene id: 8364:dars2
uniprot id: A0A6I8QQ71
uniprot id: A0A8J1JG20
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.

8364:ppp3ca
gene id: 8364:ppp3ca
uniprot id: A0A6I8R0I5
uniprot id: A0A6I8SW81
uniprot id: A0A8J0SAX0
uniprot id: B0BLZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.
messages: Cytoplasm

8364:LOC116409656
gene id: 8364:LOC116409656
uniprot id: A0A8J1JB47
names: Subcellular Location Annotation
messages: Membrane

8364:ola1
gene id: 8364:ola1
uniprot id: Q66JG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Cytoplasm
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
messages: Monomer.
messages: Nucleus
messages: nucleolus

8364:cfap97
gene id: 8364:cfap97
uniprot id: A4IJ15
names: Similarity
messages: Belongs to the CFAP97 family.

8364:flrt3
gene id: 8364:flrt3
uniprot id: B1H134
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Detected in blastula and gastrula, in dorsal mesoderm.
messages: Endoplasmic reticulum membrane
messages: Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners (By similarity). Modulates cadherin-dependent cell-cell adhesion and cell sorting (By similarity). Plays a role in the spatial organization of brain neurons. Plays a role in vascular development. Plays a role in cell-cell adhesion via its interaction with latrophilins that are expressed at the surface of adjacent cells. Mediates axon attraction towards cells expressing ntn1. mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with unc-5 family members. Plays a role in the regulation of the density of glutamaergic synapses (By similarity). Plays a role in signaling cascades downstream of fgfr1, and possibly also other fgfr family members (By similarity). Plays a role in embryonic morphogenesis, but not in embryonic patterning (PubMed:19492039).
messages: Interacts with fgfr1 and fgfr4. Interacts with rnd1, cdh1 and pcdh8. Interacts (via extracellular domain) with unc5b and unc5d (via extracellular domain) (By similarity).
messages: N-glycosylated.
messages: Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease.
messages: Secreted
messages: axon
messages: focal adhesion
messages: growth cone membrane

8364:glmp
gene id: 8364:glmp
uniprot id: A0A803K3E1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLMP family.
messages: Lysosome membrane
messages: Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.

8364:snrpa1
gene id: 8364:snrpa1
uniprot id: A0A6I8SPP8
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

8364:LOC100492951
gene id: 8364:LOC100492951
uniprot id: A0A6I8SXL7
uniprot id: A0A803JXE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8364:serpinb10
gene id: 8364:serpinb10
uniprot id: A0A6I8Q2E6
names: Similarity
messages: Belongs to the serpin family.

8364:LOC100494293
gene id: 8364:LOC100494293
uniprot id: A0A8J0T6K7
names: Similarity
messages: Belongs to the MHC class I family.

8364:nsdhl
gene id: 8364:nsdhl
uniprot id: A0A8J0PJF2
names: Similarity
messages: Belongs to the 3-beta-HSD family.

8364:LOC100494394
gene id: 8364:LOC100494394
uniprot id: F7ELZ6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:phkg1
gene id: 8364:phkg1
uniprot id: F6T0P4
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

8364:rasgef1a
gene id: 8364:rasgef1a
uniprot id: A0JM95
names: Function
messages: Guanine nucleotide exchange factor (GEF) with specificity for rap2a and other Ras family proteins (in vitro). Plays a role in cell migration (By similarity).

8364:ndufa13
gene id: 8364:ndufa13
uniprot id: Q6PBF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFA13 subunit family.
messages: Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
messages: Mitochondrion inner membrane

8364:rps27a
gene id: 8364:rps27a
uniprot id: Q28FM7
names: Similarity
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.

8364:LOC100125044
gene id: 8364:LOC100125044
uniprot id: A4IIR3
names: Similarity
messages: Belongs to the SCAR/WAVE family.

8364:nlk.2
gene id: 8364:nlk.2
uniprot id: A0A8J1IUB0
uniprot id: B1H3E1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by threonine and tyrosine phosphorylation.
messages: Activated by tyrosine and threonine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Interacts with sox11, hmgxb4/hmg2l1, rnf138/narf, stat3.1 and mef2a.
messages: Negatively regulates Wnt/beta-catenin-signaling during development. Plays a role together with sox11 in neural induction during early embryogenesis. Involved in TGFbeta-mediated mesoderm induction in early embryos, acting downstream of map3k7/tak1 to phosphorylate stat3. Augments the rnf138/narf-directed ubiquitination and degradation of tcf/lef by enhancing the association of rnf138/narf and tcf/lef. Phosphorylates mef2a to play a role in anterior neural development, including eye formation (By similarity).
messages: Nucleus

8364:casp3.1
gene id: 8364:casp3.1
uniprot id: A0A6I8PZK4
uniprot id: A0A8J1J0B2
names: Similarity
messages: Belongs to the peptidase C14A family.

8364:slc19a3.2
gene id: 8364:slc19a3.2
uniprot id: Q28C92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity.
messages: Membrane

8364:LOC101731784
gene id: 8364:LOC101731784
uniprot id: A0A8J1JF29
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:fam189b
gene id: 8364:fam189b
uniprot id: A0A8J1INI8
uniprot id: A0A8J1IQY1
names: Similarity
messages: Belongs to the ENTREP family.

8364:LOC116412270
gene id: 8364:LOC116412270
uniprot id: A0A8J1JZU6
names: Similarity
messages: Belongs to the Izumo family.

8364:nat14
gene id: 8364:nat14
uniprot id: Q28DI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the camello family.
messages: Membrane
messages: Probable acetyltransferase.

8364:adora3.1
gene id: 8364:adora3.1
uniprot id: A0A8J0QJG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

8364:ermn
gene id: 8364:ermn
uniprot id: A0A8J0QM12
names: Function
names: Subunit
messages: Binds actin.
messages: Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS.

8364:hfm1
gene id: 8364:hfm1
uniprot id: A2RUV5
names: Function
names: Similarity
messages: Belongs to the helicase family. SKI2 subfamily.
messages: Required for crossover formation and complete synapsis of homologous chromosomes during meiosis.

8364:gucy1b1
gene id: 8364:gucy1b1
uniprot id: A0A6I8SB16
uniprot id: A0A8J0R0S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

8364:fasn
gene id: 8364:fasn
uniprot id: A0A6I8QT41
names: Function
messages: Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.

8364:h1-0
gene id: 8364:h1-0
uniprot id: Q6NVM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division (By similarity).
messages: Nucleus

8364:wdr46
gene id: 8364:wdr46
uniprot id: A0A8J0QU76
names: Subcellular Location Annotation
messages: nucleolus

8364:npm2
gene id: 8364:npm2
uniprot id: A0A803KGG2
uniprot id: A9UL93
names: Similarity
messages: Belongs to the nucleoplasmin family.

8364:dnase1l2
gene id: 8364:dnase1l2
uniprot id: A0A6I8S5T0
names: Similarity
messages: Belongs to the DNase I family.

8364:sptssb
gene id: 8364:sptssb
uniprot id: B0S4Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPTSS family. SPTSSB subfamily.
messages: Component of the serine palmitoyltransferase (SPT) complex, which is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. The heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core of the enzyme, while SPTSSA or SPTSSB subunits determine substrate specificity (By similarity). SPT also interacts with ORMDL proteins, especially ORMDL3, which negatively regulate SPT activity in the presence of ceramides (By similarity).
messages: Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. Within the SPT complex, SPTSSB stimulates the catalytic activity and plays a role in substrate specificity. SPT complexes with this subunit showing a preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference.
messages: Endoplasmic reticulum membrane

8364:ltbp3
gene id: 8364:ltbp3
uniprot id: A0A8J0QR55
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:pmvk
gene id: 8364:pmvk
uniprot id: A0A8J1IQ92
names: Subcellular Location Annotation
messages: cytosol

8364:kcnt1
gene id: 8364:kcnt1
uniprot id: A0A803J2H8
uniprot id: A0A803JDE8
uniprot id: A0A8J1IKZ5
uniprot id: A0A8J1INL7
uniprot id: B4F6Q0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:drc7
gene id: 8364:drc7
uniprot id: A0A6I8PLB5
uniprot id: A0A8J1JDV1
uniprot id: A0A8J1JGC4
uniprot id: Q0V9S9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DRC7 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Involved in the regulation of flagellar motility (By similarity). Essential for male fertility, sperm head morphogenesis and sperm flagellum formation (By similarity).
messages: Component of the nexin-dynein regulatory complex (N-DRC).
messages: cilium axoneme
messages: flagellum
messages: flagellum axoneme

8364:LOC100493268
gene id: 8364:LOC100493268
uniprot id: A0A6I8QJ79
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:nxpe3l.6
gene id: 8364:nxpe3l.6
uniprot id: A0A8J0QTG8
uniprot id: A0A8J0T212
names: Similarity
messages: Belongs to the NXPE family.

8364:gipc1
gene id: 8364:gipc1
uniprot id: A0A8J0S5M3
uniprot id: Q5M7S8
names: Similarity
messages: Belongs to the GIPC family.

8364:LOC100216173
gene id: 8364:LOC100216173
uniprot id: A0A803J8F8
uniprot id: B5DDW9
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

8364:nfya
gene id: 8364:nfya
uniprot id: A0A803KLB8
uniprot id: A0A8J0SFZ8
uniprot id: A0A8J0SH54
uniprot id: A0A8J0SH71
uniprot id: A0A8J1J1C7
uniprot id: A0A8J1J1D0
uniprot id: A0A8J1J3S0
uniprot id: F6QN52
uniprot id: Q6P814
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

8364:grpr
gene id: 8364:grpr
uniprot id: A0A6I8Q016
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:pdha1
gene id: 8364:pdha1
uniprot id: A0A8J0SFT1
uniprot id: Q28G62
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

8364:ncstn
gene id: 8364:ncstn
uniprot id: A0A6I8PML7
uniprot id: A0A8J0QDN2
uniprot id: B3DL59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicastrin family.
messages: Membrane

8364:ttc39a
gene id: 8364:ttc39a
uniprot id: Q28D40
names: Similarity
messages: Belongs to the TTC39 family.

8364:htra3
gene id: 8364:htra3
uniprot id: A0A6I8Q0T9
names: Similarity
messages: Belongs to the peptidase S1C family.

8364:ptp4a3
gene id: 8364:ptp4a3
uniprot id: B3DLA8
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

8364:foxr1
gene id: 8364:foxr1
uniprot id: Q0P4K5
uniprot id: Q28H65
names: Subcellular Location Annotation
messages: Nucleus

8364:sema3d
gene id: 8364:sema3d
uniprot id: A0A8J0QPU1
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:sp9
gene id: 8364:sp9
uniprot id: Q0VA40
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Sp1 C2H2-type zinc-finger protein family.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In SP9, the motif is inactive.
messages: Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity).

8364:pnpla4
gene id: 8364:pnpla4
uniprot id: A0A8J0R0U4
uniprot id: A0A8J1J693
uniprot id: A0A8J1J7B4
uniprot id: F6SLH7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:ppat
gene id: 8364:ppat
uniprot id: Q6P2Z4
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

8364:dynll1
gene id: 8364:dynll1
uniprot id: Q6DEU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

8364:ugt3a2
gene id: 8364:ugt3a2
uniprot id: A0A8J0PD78
uniprot id: F6UP07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

8364:hip1
gene id: 8364:hip1
uniprot id: F6Y171
names: Similarity
messages: Belongs to the SLA2 family.

8364:stard13
gene id: 8364:stard13
uniprot id: A0A6I8PSI3
uniprot id: A0A6I8SKZ1
uniprot id: A0A6I8T0C3
names: Subcellular Location Annotation
messages: Cytoplasm

8364:gpr20
gene id: 8364:gpr20
uniprot id: F7D1Z1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:napsa
gene id: 8364:napsa
uniprot id: Q6DJB0
names: Similarity
messages: Belongs to the peptidase A1 family.

8364:p2ry8
gene id: 8364:p2ry8
uniprot id: A0A803K885
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:onecut1
gene id: 8364:onecut1
uniprot id: A0A6I8SYT1
uniprot id: A4II00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

8364:med12
gene id: 8364:med12
uniprot id: A0A6I8PL47
uniprot id: A0A8J0SW97
uniprot id: A0A8J1ISA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 12 family.
messages: Nucleus

8364:serpina1
gene id: 8364:serpina1
uniprot id: A0A6I8SV03
uniprot id: A0A8J0R442
names: Similarity
messages: Belongs to the serpin family.

8364:glt1d1
gene id: 8364:glt1d1
uniprot id: Q6DIQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Secreted

8364:pah
gene id: 8364:pah
uniprot id: Q4VBE2
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

8364:ttc4
gene id: 8364:ttc4
uniprot id: A0A8J0QKL7
uniprot id: A0A8J0R495
names: Similarity
messages: Belongs to the TTC4 family.

8364:itpkb
gene id: 8364:itpkb
uniprot id: A0A8J0QVE2
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

8364:snx8
gene id: 8364:snx8
uniprot id: A0A8J1ISW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

8364:gprc5cl2
gene id: 8364:gprc5cl2
uniprot id: A0A6I8Q8V3
uniprot id: A0A6I8R240
uniprot id: A0A8J0R5B0
uniprot id: A0A8J0SUT2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:pi4kb
gene id: 8364:pi4kb
uniprot id: A4IID4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
messages: Endomembrane system
messages: Mitochondrion outer membrane
messages: Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May play an important role in the inner ear development.
messages: Rough endoplasmic reticulum membrane

8364:dut
gene id: 8364:dut
uniprot id: A0A6I8RWX6
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

8364:rprd1a
gene id: 8364:rprd1a
uniprot id: F6PM62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.
messages: Nucleus

8364:LOC116407534
gene id: 8364:LOC116407534
uniprot id: A0A8J1IVK6
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100493571
gene id: 8364:LOC100493571
uniprot id: A0A8J0SAE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:ces3.4
gene id: 8364:ces3.4
uniprot id: A0A8J0SLQ8
uniprot id: Q640T6
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

8364:LOC101732535
gene id: 8364:LOC101732535
uniprot id: A0A8J1JX55
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.

8364:golga5
gene id: 8364:golga5
uniprot id: B7ZTX8
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.

8364:cd9
gene id: 8364:cd9
uniprot id: Q28EH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Membrane
messages: extracellular exosome

8364:LOC100487642
gene id: 8364:LOC100487642
uniprot id: A0A8J0T2E9
names: Similarity
messages: Belongs to the Izumo family.

8364:sepsecs
gene id: 8364:sepsecs
uniprot id: Q28EN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm
messages: Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.

8364:LOC100493005
gene id: 8364:LOC100493005
uniprot id: A0A8J0QUF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:colgalt2
gene id: 8364:colgalt2
uniprot id: F6ZQT7
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

8364:slc35a4
gene id: 8364:slc35a4
uniprot id: A0A803KCL2
uniprot id: A4IHW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Mediates the transport of CDP-ribitol (By similarity). Does not exhibit CMP-sialic acid, UDP-galactose and UDP-N-acetylglucosamine transport activity (By similarity).
messages: Membrane

8364:cyb561
gene id: 8364:cyb561
uniprot id: Q6GL84
names: Subcellular Location Annotation
messages: Membrane

8364:pola2
gene id: 8364:pola2
uniprot id: Q6DEY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
messages: Belongs to the DNA polymerase alpha subunit B family.
messages: Nucleus

8364:cndp1
gene id: 8364:cndp1
uniprot id: A9ULN9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

8364:ncdn
gene id: 8364:ncdn
uniprot id: F6ZZX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurochondrin family.
messages: Postsynapse

8364:crygdl.14
gene id: 8364:crygdl.14
uniprot id: A0A8J0QQ49
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:wdyhv1
gene id: 8364:wdyhv1
uniprot id: A0A310SUL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NTAQ1 family.
messages: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.
messages: Monomer.

8364:cmtm6
gene id: 8364:cmtm6
uniprot id: Q28D06
names: Subcellular Location Annotation
messages: Membrane

8364:LOC105945576
gene id: 8364:LOC105945576
uniprot id: A0A8J1JNM3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:kdm6a
gene id: 8364:kdm6a
uniprot id: A0A6I8Q636
uniprot id: A0A6I8RM91
uniprot id: B3DLW8
uniprot id: F7AAH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTX family.
messages: Nucleus

8364:dynlrb1
gene id: 8364:dynlrb1
uniprot id: A0A803KHJ5
uniprot id: A0A8J0SYI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: cytoskeleton

8364:LOC116411039
gene id: 8364:LOC116411039
uniprot id: A0A8J1JPX8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:pnpt1
gene id: 8364:pnpt1
uniprot id: Q28FH4
names: Similarity
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.

8364:mical3
gene id: 8364:mical3
uniprot id: A0A8J0S9Y4
uniprot id: A0A8J0SHT5
uniprot id: A0A8J0SHU0
uniprot id: A0A8J0SJ23
uniprot id: A0A8J0SJ28
uniprot id: A0A8J1J989
uniprot id: A0A8J1J993
uniprot id: A0A8J1J994
uniprot id: A0A8J1J995
uniprot id: A0A8J1J998
uniprot id: A0A8J1J9A0
uniprot id: A0A8J1J9A1
uniprot id: A0A8J1J9A3
uniprot id: A0A8J1J9A4
uniprot id: A0A8J1J9A7
uniprot id: A0A8J1JBP7
uniprot id: A0A8J1JBQ3
uniprot id: A0A8J1JBQ8
uniprot id: A0A8J1JBR2
uniprot id: A0A8J1JCS5
uniprot id: A0A8J1JCT0
uniprot id: A0A8J1JCT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mical family.
messages: Cytoplasm

8364:otud7b
gene id: 8364:otud7b
uniprot id: A0A6I8SEH3
uniprot id: F6SZ91
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:vars2
gene id: 8364:vars2
uniprot id: F7EBD8
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

8364:sfxn5
gene id: 8364:sfxn5
uniprot id: A0A6I8QRK3
uniprot id: Q6DJ23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

8364:hdac4
gene id: 8364:hdac4
uniprot id: A0A6I8RRK0
uniprot id: A0A8J0R4X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

8364:zwilch
gene id: 8364:zwilch
uniprot id: Q0IJ01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZWILCH family.
messages: Component of the RZZ complex composed of kntc1/rod, zw10 and zwilch.
messages: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and mad1-mad2 complexes onto kinetochores (By similarity).
messages: kinetochore

8364:LOC101731944
gene id: 8364:LOC101731944
uniprot id: A0A803JC38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:neurod2
gene id: 8364:neurod2
uniprot id: Q0P4T4
names: Subcellular Location Annotation
messages: Nucleus

8364:aida
gene id: 8364:aida
uniprot id: A0A6I8R3F6
uniprot id: A0A8J0SDV4
uniprot id: F7E6Y8
uniprot id: Q6P821
names: Similarity
messages: Belongs to the AIDA family.

8364:dock3
gene id: 8364:dock3
uniprot id: A0A6I8Q1F7
uniprot id: A0A6I8QM05
uniprot id: A0A6I8R3E6
uniprot id: A0A8J1JGJ0
names: Similarity
messages: Belongs to the DOCK family.

8364:trpm3
gene id: 8364:trpm3
uniprot id: A0A6I8QZK1
names: Subcellular Location Annotation
messages: Membrane

8364:rgs4
gene id: 8364:rgs4
uniprot id: F6SU43
uniprot id: Q6P300
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

8364:LOC100489523
gene id: 8364:LOC100489523
uniprot id: A0A803K0W2
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:map7d2
gene id: 8364:map7d2
uniprot id: A0A803JJY7
uniprot id: A0A8J0S831
uniprot id: A0A8J0SD99
uniprot id: A0A8J0SF61
uniprot id: A0A8J0SG74
uniprot id: A0A8J1J2D9
uniprot id: A0A8J1J5T4
uniprot id: F6YKE8
uniprot id: Q08CX9
names: Similarity
messages: Belongs to the MAP7 family.

8364:telo2
gene id: 8364:telo2
uniprot id: F6SWJ1
uniprot id: Q08CY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TEL2 family.
messages: Cytoplasm
messages: Membrane
messages: Nucleus
messages: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. Promotes assembly, stabilizes and maintains the activity of TORC complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation (By similarity).
messages: telomere

8364:tlr9
gene id: 8364:tlr9
uniprot id: A0A8J0T2J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

8364:gbp3
gene id: 8364:gbp3
uniprot id: A0A8J0QQM3
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8364:ethe1
gene id: 8364:ethe1
uniprot id: F6WYM3
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

8364:eif4g2
gene id: 8364:eif4g2
uniprot id: A0A8J1JFS6
uniprot id: Q6DIH1
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

8364:pdcl3
gene id: 8364:pdcl3
uniprot id: A0A803J208
uniprot id: Q5M7M0
names: Similarity
messages: Belongs to the phosducin family.

8364:cdc37l1
gene id: 8364:cdc37l1
uniprot id: A0A8J0SPV3
uniprot id: A0A8J0SPV8
uniprot id: A0A8J0SPY8
uniprot id: B2RYX3
uniprot id: Q28HY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC37 family.
messages: Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90.
messages: Cytoplasm
messages: Forms complexes with Hsp70 and Hsp90.

8364:LOC619584
gene id: 8364:LOC619584
uniprot id: A0A8J0R215
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:LOC101730635
gene id: 8364:LOC101730635
uniprot id: Q28H66
names: Subcellular Location Annotation
messages: Membrane

8364:nme3
gene id: 8364:nme3
uniprot id: A0A6I8QKB7
uniprot id: Q6DEP3
names: Similarity
messages: Belongs to the NDK family.

8364:mmp1
gene id: 8364:mmp1
uniprot id: Q28IS0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

8364:tspan33
gene id: 8364:tspan33
uniprot id: A0A8J1JAP8
uniprot id: F7E853
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8364:ocm4.5
gene id: 8364:ocm4.5
uniprot id: B0JZ24
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

8364:LOC100495494
gene id: 8364:LOC100495494
uniprot id: A0A8J0T270
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:nfs1
gene id: 8364:nfs1
uniprot id: F7CA14
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

8364:slc45a4
gene id: 8364:slc45a4
uniprot id: F7D1N3
names: Subcellular Location Annotation
messages: Membrane

8364:mafa
gene id: 8364:mafa
uniprot id: Q4U1U2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Maf subfamily.
messages: During embryonic development, expressed in somites. First detected in stage 24 and remains excluded from the 2-3 caudal-most somites at all studied stages. First detectable in the developing hindbrain at stage 24. Expressed persists until stage 33. At stage 43, expressed in the olfactory bulb and thalamus.
messages: Nucleus
messages: Transcription factor, possibly involved in transcription regulation during lens development.

8364:ndufa12
gene id: 8364:ndufa12
uniprot id: Q5XGC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

8364:LOC116411054
gene id: 8364:LOC116411054
uniprot id: A0A8J1JLD8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:h3-3b
gene id: 8364:h3-3b
uniprot id: A9JTR4
uniprot id: Q6P823
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Monoubiquitinated by rag1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin. Phosphorylation on Ser-32 (H3S31ph) is specific to regions bordering centromeres in metaphase chromosomes.
messages: Serine ADP-ribosylation constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Specific interaction of trimethylated form at 'Lys-36' (H3.3K36me3) with zmynd11 is mediated by the encapsulation of Ser-32 residue with a composite pocket formed by the tandem bromo-PWWP domains.
messages: Specifically enriched in modifications associated with active chromatin such as methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with zmynd11; when trimethylated at 'Lys-36' (H3.3K36me3).
messages: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

8364:LOC116412466
gene id: 8364:LOC116412466
uniprot id: A0A803KEP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8364:tas2r8
gene id: 8364:tas2r8
uniprot id: Q2AB52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:ypel1
gene id: 8364:ypel1
uniprot id: Q28IZ9
names: Similarity
messages: Belongs to the yippee family.

8364:zhx3
gene id: 8364:zhx3
uniprot id: Q6DF25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

8364:znrf1
gene id: 8364:znrf1
uniprot id: F7EP40
names: Domain
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase that plays a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity.
messages: Endosome
messages: Lysosome
messages: Membrane
messages: The RING-type zinc finger domain is required for E3 ligase activity.

8364:cog8
gene id: 8364:cog8
uniprot id: F6ZX42
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG8 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane

8364:rpusd2
gene id: 8364:rpusd2
uniprot id: A0A8J0QXB5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

8364:pea15
gene id: 8364:pea15
uniprot id: A0A8J0SMI1
uniprot id: B1H1K2
names: Subcellular Location Annotation
messages: Cytoplasm

8364:tpp2
gene id: 8364:tpp2
uniprot id: A0A8J0QMU4
uniprot id: F6RTC3
names: Similarity
messages: Belongs to the peptidase S8 family.

8364:pim3
gene id: 8364:pim3
uniprot id: F7BCJ7
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

8364:ptdss1
gene id: 8364:ptdss1
uniprot id: B1H3H9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (By similarity). Catalyzes mainly the conversion of phosphatidylcholine but also converts, in vitro and to a lesser extent, phosphatidylethanolamine (By similarity).
messages: Endoplasmic reticulum membrane

8364:pla2g4a
gene id: 8364:pla2g4a
uniprot id: A0A8J1JCW2
uniprot id: B1WAZ6
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response (By similarity).
messages: Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca(2+).
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity).

8364:reep6
gene id: 8364:reep6
uniprot id: A0A6I8QFD1
uniprot id: Q28EU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

8364:trpm7
gene id: 8364:trpm7
uniprot id: A0A8J0QVH9
uniprot id: A0A8J0SHY6
uniprot id: A0A8J0SJ72
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
messages: Membrane

8364:cnr2
gene id: 8364:cnr2
uniprot id: F6QM39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:itm2b
gene id: 8364:itm2b
uniprot id: Q6P3P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

8364:fzd7
gene id: 8364:fzd7
uniprot id: Q5BL72
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Endosome membrane
messages: Interacts with wnt11 and sdc4. The extracellular domain interacts with the extracellular domain of pcdh8/papc (By similarity).
messages: Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
messages: Receptor for Wnt proteins. Acts in both canonical and non-canonical Wnt pathways. Although different papers report differing Wnt preferences, wnt5a, wnt8b and wnt11 have been proposed as synergists. In the canonical Wnt pathway, acts via beta-catenin to promote the expression of the dorsal genes siamois, twin and nodal3 and to establish the dorsal axis of the embryo and induce dorsal mesoderm formation. In a non-canonical Wnt/planar cell polarity (PCP) pathway, acts with sdc4 and dvl2/dsh to regulate convergent extension movements in gastrulation. Triggers phosphorylation of dvl2/dsh and its translocation to the plasma membrane. In a third branch of Wnt signaling, acts in a non-canonical pathway via trimeric G proteins, and independently of dvl2/dsh, to recruit protein kinase C (PKC) to the membrane and thus activate PKC. PKC signaling controls cell sorting and tissue separation during gastrulation (By similarity).
messages: The FZ domain is involved in binding with Wnt ligands.
messages: The extracellular domain interacts with Wnt proteins and the intracellular C-terminus transmits the Wnt signal.

8364:bpi
gene id: 8364:bpi
uniprot id: A0A6I8PZ68
uniprot id: Q5FWR5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

8364:LOC100491569
gene id: 8364:LOC100491569
uniprot id: F6RU66
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8364:dio3
gene id: 8364:dio3
uniprot id: A0A8J0QA53
uniprot id: A9ULG7
names: Function
names: Similarity
messages: Belongs to the iodothyronine deiodinase family.
messages: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).

8364:LOC100497097
gene id: 8364:LOC100497097
uniprot id: A0A8J0R1A0
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

8364:LOC105948101
gene id: 8364:LOC105948101
uniprot id: A0A8J1IPP9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:fn3krp
gene id: 8364:fn3krp
uniprot id: A0A8J1IWU5
uniprot id: Q0VFK9
names: Similarity
messages: Belongs to the fructosamine kinase family.

8364:exoc3l4
gene id: 8364:exoc3l4
uniprot id: A0A803KBX6
names: Similarity
messages: Belongs to the SEC6 family.

8364:LOC100487643
gene id: 8364:LOC100487643
uniprot id: L7N2H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

8364:fam131b
gene id: 8364:fam131b
uniprot id: A0A8J1JUF1
uniprot id: A0A8J1JWV3
uniprot id: A0A8J1JY93
names: Similarity
messages: Belongs to the FAM131 family.

8364:tnfrsf10b
gene id: 8364:tnfrsf10b
uniprot id: A0A8J0T281
uniprot id: Q6DJ81
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC496737
gene id: 8364:LOC496737
uniprot id: Q5M8J3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

8364:nsmce2
gene id: 8364:nsmce2
uniprot id: A0A6I8RW27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

8364:slc47a1
gene id: 8364:slc47a1
uniprot id: A0A6I8SPR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

8364:zar1l
gene id: 8364:zar1l
uniprot id: A0A6I8SKU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZAR1 family.
messages: Cytoplasmic ribonucleoprotein granule

8364:mast4
gene id: 8364:mast4
uniprot id: A0A6I8R5M8
uniprot id: A0A6I8SEE3
uniprot id: A0A6I8SH47
uniprot id: A0A8J0QL46
uniprot id: A0A8J0SJF1
uniprot id: A0A8J1IYN3
uniprot id: A0A8J1IYP0
uniprot id: F6Z180
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

8364:lpcat4
gene id: 8364:lpcat4
uniprot id: A0A8J0SCG3
uniprot id: Q28C60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates. Prefers long chain acyl-CoAs (C16, C18) as acyl donors (By similarity).
messages: Endoplasmic reticulum membrane

8364:kpna2
gene id: 8364:kpna2
uniprot id: A0A8J0STA5
uniprot id: Q28FD3
uniprot id: Q66IF6
names: Similarity
messages: Belongs to the importin alpha family.

8364:atg101
gene id: 8364:atg101
uniprot id: A0A6I8SXC4
uniprot id: A4IH75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autophagy factor required for autophagosome formation.
messages: Belongs to the ATG101 family.
messages: Cytoplasm
messages: Preautophagosomal structure

8364:t2r35
gene id: 8364:t2r35
uniprot id: Q2AB50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:eif1ax
gene id: 8364:eif1ax
uniprot id: Q6GLB2
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1.

8364:cldn23
gene id: 8364:cldn23
uniprot id: A0A803KA29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

8364:chst11
gene id: 8364:chst11
uniprot id: A0A6I8Q0S9
uniprot id: A4QNQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:spock3
gene id: 8364:spock3
uniprot id: A0A8J0SJX5
uniprot id: A4II43
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:tob2
gene id: 8364:tob2
uniprot id: Q28CL2
names: Similarity
messages: Belongs to the BTG family.

8364:dph6
gene id: 8364:dph6
uniprot id: A0A6I8SDE7
uniprot id: A0A8J0QIB0
uniprot id: A0A8J1IQU7
names: Similarity
messages: Belongs to the Diphthine--ammonia ligase family.

8364:nme7
gene id: 8364:nme7
uniprot id: Q6P7M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: cilium axoneme

8364:clgn
gene id: 8364:clgn
uniprot id: A0A6I8RW68
names: Similarity
messages: Belongs to the calreticulin family.

8364:prkacb
gene id: 8364:prkacb
uniprot id: A0A803JUQ3
uniprot id: A0A8J1JEX4
uniprot id: F6UP78
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

8364:LOC100492011
gene id: 8364:LOC100492011
uniprot id: A0A8J0SW54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:uba5
gene id: 8364:uba5
uniprot id: Q6GLG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
messages: Cytoplasm
messages: E1-like enzyme which specifically catalyzes the first step in ufmylation. Activates ufm1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ufm1-E1 thioester and free AMP. Activates ufm1 via a trans-binding mechanism, in which ufm1 interacts with distinct sites in both subunits of the uba5 homodimer. Trans-binding also promotes stabilization of the uba5 homodimer, and enhances ATP-binding. Transfer of ufm1 from uba5 to the E2-like enzyme UFC1 also takes place using a trans mechanism. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus
messages: Homodimer; homodimerization is required for ufm1 activation. Interacts (via UIS motif) with ufm1; binds ufm1 via a trans-binding mechanism in which ufm1 interacts with distinct sites in both subunits of the uba5 homodimer. Interacts (via C-terminus) with ufc1.
messages: Nucleus

8364:LOC100492198
gene id: 8364:LOC100492198
uniprot id: A0A8J0QU04
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:pkn2
gene id: 8364:pkn2
uniprot id: F7CM85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

8364:gpr107
gene id: 8364:gpr107
uniprot id: A0A803KIQ6
names: Subcellular Location Annotation
messages: Membrane

8364:mgat2
gene id: 8364:mgat2
uniprot id: Q6DIJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 16 (GT16) protein family.
messages: Golgi apparatus membrane
messages: Membrane

8364:kitlg
gene id: 8364:kitlg
uniprot id: B4F6K4
uniprot id: Q28DP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCF family.
messages: Cytoplasm
messages: Homodimer, non-covalently linked.
messages: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.
messages: Secreted
messages: filopodium
messages: lamellipodium

8364:wdr37
gene id: 8364:wdr37
uniprot id: A4IIX9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:rptor
gene id: 8364:rptor
uniprot id: A0A6I8RIN4
uniprot id: A0A8J0SWS2
uniprot id: A0A8J0SYM3
uniprot id: B3DM55
uniprot id: F6U7W9
names: Similarity
messages: Belongs to the WD repeat RAPTOR family.

8364:rbpj
gene id: 8364:rbpj
uniprot id: A0A803J8V4
uniprot id: A0A8J1J2F3
uniprot id: A0A8J1J3D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Su(H) family.
messages: Nucleus

8364:prdm8
gene id: 8364:prdm8
uniprot id: Q28BY3
names: Subcellular Location Annotation
messages: Nucleus

8364:nr2e3
gene id: 8364:nr2e3
uniprot id: A0FCT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

8364:dand5
gene id: 8364:dand5
uniprot id: A9JTK0
uniprot id: Q28H35
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAN family.
messages: Interacts with nr1-a.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in regulating the left-right axis by blocking a tgfb1 cascade in the right posterior paraxial mesoderm. Functions as an inhibitor of bmp, tgfb1, nodal, activin and wnt signaling in the ectoderm. May inhibit mesodermal signals, probably through an inhibition of nodal/activin pathways. Seems to regulates cell fate specification and competence before the onset of neural induction. Expression in the entire ectodermal region prior to gastrulation might act to prevent fate specification in the ectoderm and ensure the maintenance of the stem-cell-like properties exhibited by ectodermal cells (By similarity).
messages: Secreted

8364:wdr45b
gene id: 8364:wdr45b
uniprot id: Q640T2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P), and other phosphoinositides including PtdIns(3,5)P2, forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2.
messages: Lysosome
messages: Preautophagosomal structure
messages: The L/FRRG motif is required for recruitment to PtdIns3P.

8364:LOC116408615
gene id: 8364:LOC116408615
uniprot id: A0A8J1J2P3
names: Subcellular Location Annotation
messages: Membrane

8364:slc8a3
gene id: 8364:slc8a3
uniprot id: A0A6I8Q9H8
uniprot id: A0A6I8SWX1
uniprot id: A0A8J0QT17
uniprot id: A0A8J0R2H9
uniprot id: A0A8J0R678
uniprot id: A0A8J0R6S3
uniprot id: A0A8J0R754
uniprot id: A0A8J0SXH0
uniprot id: A0A8J1IQK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

8364:dll1
gene id: 8364:dll1
uniprot id: F6U5P5
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

8364:LOC549154
gene id: 8364:LOC549154
uniprot id: A0A8J1JH02
uniprot id: F7CA63
uniprot id: Q28GZ2
names: Similarity
messages: Belongs to the BtpA family.

8364:LOC116409813
gene id: 8364:LOC116409813
uniprot id: B0JZ06
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:dda1
gene id: 8364:dda1
uniprot id: A0A8J0SPA9
uniprot id: Q5BL73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DDA1 family.
messages: Component of numerous DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which consist of a core of DDB1, cullin-4 (CUL4A or CUL4B), DDA1 and RBX1.
messages: Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex.

8364:LOC100144919
gene id: 8364:LOC100144919
uniprot id: A0A8J0SRI1
uniprot id: A0A8J0SST2
uniprot id: B0BLT9
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8364:cyp26c1
gene id: 8364:cyp26c1
uniprot id: F7AXB0
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:arhgef11
gene id: 8364:arhgef11
uniprot id: A0A6I8Q4D9
uniprot id: A0A6I8QAA5
uniprot id: A0A6I8SBA1
uniprot id: A0A8J1IPE3
uniprot id: A0A8J1IPE5
uniprot id: A0A8J1IPE6
uniprot id: A0A8J1IRU5
uniprot id: A0A8J1ISI9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

8364:atp1b2
gene id: 8364:atp1b2
uniprot id: Q6P8E5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

8364:mapk10
gene id: 8364:mapk10
uniprot id: A0A8J0QFD4
uniprot id: A0A8J0QGY5
uniprot id: A0A8J0T3H7
uniprot id: A0A8J1JHC4
uniprot id: A0A8J1JJR2
uniprot id: A0A8J1JKV4
uniprot id: A0A8J1JKW0
uniprot id: A0A8J1JKW5
uniprot id: A7MC39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

8364:hmgb3
gene id: 8364:hmgb3
uniprot id: Q6DJ93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

8364:marchf8
gene id: 8364:marchf8
uniprot id: Q28IK8
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle membrane
messages: E3 ubiquitin-protein ligase that mediates ubiquitination of cd86 and MHC class II proteins, such as hla-dr alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies.
messages: Early endosome membrane
messages: Lysosome membrane
messages: The RING-CH-type zinc finger domain is required for E3 ligase activity.

8364:slc17a8
gene id: 8364:slc17a8
uniprot id: A0A8J0QPR2
names: Subcellular Location Annotation
messages: Membrane

8364:sorcs2
gene id: 8364:sorcs2
uniprot id: A0A6I8RWP2
uniprot id: A0A8J0QPJ7
names: Similarity
messages: Belongs to the VPS10-related sortilin family. SORCS subfamily.

8364:prkaa1
gene id: 8364:prkaa1
uniprot id: B1H2Z8
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

8364:st6galnac6
gene id: 8364:st6galnac6
uniprot id: A0A803JLE8
uniprot id: A0A8J1IL02
uniprot id: D2U4U3
uniprot id: F6PR61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8364:gnrhr
gene id: 8364:gnrhr
uniprot id: F6WKZ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:ncr3
gene id: 8364:ncr3
uniprot id: A0A8J1JH56
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natural cytotoxicity receptor (NCR) family.
messages: Cell membrane
messages: Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6.
messages: Membrane

8364:mfap2
gene id: 8364:mfap2
uniprot id: Q6P8D5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:slc4a9
gene id: 8364:slc4a9
uniprot id: A0A6I8RCR7
uniprot id: A0A8J0SGP4
uniprot id: A0A8J0SJL5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: Membrane

8364:LOC116406475
gene id: 8364:LOC116406475
uniprot id: A0A8J1ITQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:fgfbp2
gene id: 8364:fgfbp2
uniprot id: A0A803K540
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

8364:LOC100495518
gene id: 8364:LOC100495518
uniprot id: A0A6I8QSC6
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:rnf157
gene id: 8364:rnf157
uniprot id: A0A8J0SBM2
uniprot id: A0A8J1IWQ3
uniprot id: Q0V9Q3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin ligase.

8364:cntnap4
gene id: 8364:cntnap4
uniprot id: F6QB73
names: Caution
names: Similarity
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:st13
gene id: 8364:st13
uniprot id: Q6DIN1
names: Similarity
messages: Belongs to the FAM10 family.

8364:tnfsf11
gene id: 8364:tnfsf11
uniprot id: F6XUG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Membrane
messages: Secreted

8364:LOC116408039
gene id: 8364:LOC116408039
uniprot id: A0A8J1IYF1
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:pigf
gene id: 8364:pigf
uniprot id: B7ZT49
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:cct2
gene id: 8364:cct2
uniprot id: Q6DIK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

8364:wnt3
gene id: 8364:wnt3
uniprot id: A4ZGP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8364:hrh2
gene id: 8364:hrh2
uniprot id: A0A803JUZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:pmpcb
gene id: 8364:pmpcb
uniprot id: A0A8J1JA20
uniprot id: Q0V9F0
names: Similarity
messages: Belongs to the peptidase M16 family.

8364:nab1
gene id: 8364:nab1
uniprot id: A0A803J6S7
uniprot id: B1H0X5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

8364:LOC100496158
gene id: 8364:LOC100496158
uniprot id: A0A6I8RPW8
uniprot id: A0A6I8S817
uniprot id: A0A8J0QPB6
uniprot id: A0A8J0QQF8
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

8364:cdh7
gene id: 8364:cdh7
uniprot id: F7DV57
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane

8364:thtpa
gene id: 8364:thtpa
uniprot id: A4IGR6
uniprot id: F6X8N1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThTPase family.
messages: Cytoplasm
messages: Hydrolase highly specific for thiamine triphosphate (ThTP).
messages: Monomer.

8364:eva1c
gene id: 8364:eva1c
uniprot id: A0A803J8E2
uniprot id: A0A8J0QZ17
names: Similarity
messages: Belongs to the EVA1 family.

8364:jmy
gene id: 8364:jmy
uniprot id: A8E4X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics.
messages: Belongs to the JMY family.
messages: Cytoplasmic vesicle
messages: Endomembrane system
messages: Nucleus
messages: autophagosome membrane
messages: cytoskeleton

8364:LOC116412386
gene id: 8364:LOC116412386
uniprot id: A0A8J1JWZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

8364:septin11
gene id: 8364:septin11
uniprot id: A0A6I8Q7Y6
uniprot id: A0A8J1J640
uniprot id: A0A8J1J643
uniprot id: A0A8J1J8I5
uniprot id: A0A8J1J9I9
uniprot id: A0A8J1J9J4
uniprot id: B1H3L0
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

8364:LOC101732403
gene id: 8364:LOC101732403
uniprot id: A0A8J1ISZ3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:acod1la
gene id: 8364:acod1la
uniprot id: A0A6I8Q718
names: Similarity
messages: Belongs to the PrpD family.

8364:itgad
gene id: 8364:itgad
uniprot id: A0A6I8Q475
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:cd3e
gene id: 8364:cd3e
uniprot id: F6VBD7
names: Subcellular Location Annotation
messages: Membrane

8364:syne1
gene id: 8364:syne1
uniprot id: A0A803JN15
uniprot id: A0A8J0STQ0
uniprot id: A0A8J0T0Q5
uniprot id: A0A8J0T350
uniprot id: A0A8J0T3Y4
uniprot id: F7BMN0
names: Similarity
messages: Belongs to the nesprin family.

8364:LOC100490971
gene id: 8364:LOC100490971
uniprot id: A0A8J1J1C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

8364:prdm1
gene id: 8364:prdm1
uniprot id: F6RF85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

8364:tspan7
gene id: 8364:tspan7
uniprot id: Q6P2Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8364:LOC100495666
gene id: 8364:LOC100495666
uniprot id: A0A8J0QYV2
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

8364:ube2t
gene id: 8364:ube2t
uniprot id: A0A803J6A4
uniprot id: A0A8J0R057
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8364:pigh
gene id: 8364:pigh
uniprot id: A0A6I8Q148
names: Similarity
messages: Belongs to the PIGH family.

8364:LOC116412463
gene id: 8364:LOC116412463
uniprot id: F7C998
names: Subcellular Location Annotation
names: Subunit
messages: May interact with TSPO.
messages: Mitochondrion

8364:LOC116409573
gene id: 8364:LOC116409573
uniprot id: A0A8J1J8D9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC100489330
gene id: 8364:LOC100489330
uniprot id: A0A8J0R8J4
names: Subcellular Location Annotation
messages: Membrane

8364:LOC101733428
gene id: 8364:LOC101733428
uniprot id: A0A8J1IMJ8
uniprot id: A0A8J1IPU4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC100491186
gene id: 8364:LOC100491186
uniprot id: A0A8J1IWS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8364:slc6a1
gene id: 8364:slc6a1
uniprot id: A0A8J0QVL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8364:b3gnt5
gene id: 8364:b3gnt5
uniprot id: Q6P3P5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids.
messages: Golgi apparatus membrane

8364:gyg2
gene id: 8364:gyg2
uniprot id: A0A6I8R8E4
uniprot id: Q5M7A1
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100496569
gene id: 8364:LOC100496569
uniprot id: A0A8J0QI25
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

8364:lsm8
gene id: 8364:lsm8
uniprot id: F6VGY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

8364:gdi1
gene id: 8364:gdi1
uniprot id: A0A1B8Y2F0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

8364:tcea3
gene id: 8364:tcea3
uniprot id: Q28G46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

8364:cnn3
gene id: 8364:cnn3
uniprot id: A0A8J0SI07
uniprot id: Q6P3P3
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

8364:sco2
gene id: 8364:sco2
uniprot id: A0A1B8Y6H5
uniprot id: A0A803J599
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCO1/2 family.
messages: Mitochondrion inner membrane

8364:LOC101733971
gene id: 8364:LOC101733971
uniprot id: A0A1B8XVM9
names: Similarity
messages: Belongs to the cyclin family.

8364:cdc42ep3
gene id: 8364:cdc42ep3
uniprot id: Q28CX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

8364:actn4
gene id: 8364:actn4
uniprot id: A0A6I8RJ91
uniprot id: A0A8J0SVY0
uniprot id: A0A8J0T635
uniprot id: Q6DFP7
names: Similarity
messages: Belongs to the alpha-actinin family.

8364:abcc1
gene id: 8364:abcc1
uniprot id: A0A6I8QSY5
uniprot id: A0A7D9NK67
uniprot id: A0A8J0QC75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

8364:dpys
gene id: 8364:dpys
uniprot id: A0A6I8QRK0
uniprot id: A0A8J1JQ72
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

8364:MGC69309
gene id: 8364:MGC69309
uniprot id: A0A8J0SIE8
uniprot id: F6U353
names: Subcellular Location Annotation
messages: Membrane

8364:thoc6
gene id: 8364:thoc6
uniprot id: F7BYE1
names: Similarity
messages: Belongs to the WD repeat THOC6 family.

8364:add2
gene id: 8364:add2
uniprot id: A4IIR0
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

8364:fyn
gene id: 8364:fyn
uniprot id: A0A6I8RSV6
uniprot id: F6S8L5
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

8364:ss18l2
gene id: 8364:ss18l2
uniprot id: A0A803JL27
names: Similarity
messages: Belongs to the SS18 family.

8364:ube2k
gene id: 8364:ube2k
uniprot id: Q6GL28
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8364:ercc2
gene id: 8364:ercc2
uniprot id: Q66II2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

8364:parp6
gene id: 8364:parp6
uniprot id: A0A8J0SPJ5
uniprot id: A0A8J1J670
uniprot id: A4IGR1
names: Similarity
messages: Belongs to the ARTD/PARP family.

8364:acsm3
gene id: 8364:acsm3
uniprot id: F6TG65
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

8364:mchr1.1
gene id: 8364:mchr1.1
uniprot id: F7E9A2
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with NCDN.
messages: Membrane

8364:LOC116411996
gene id: 8364:LOC116411996
uniprot id: A0A8J1JUF2
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:polr3d
gene id: 8364:polr3d
uniprot id: Q28DL8
names: Subcellular Location Annotation
messages: Nucleus

8364:foxp3
gene id: 8364:foxp3
uniprot id: A0A803JTF7
names: Subcellular Location Annotation
messages: Nucleus

8364:clca1.3
gene id: 8364:clca1.3
uniprot id: A0A8J0SMW4
names: Similarity
messages: Belongs to the CLCR family.

8364:sox17b.1
gene id: 8364:sox17b.1
uniprot id: Q8AWH2
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed throughout all the deep and superficial endoderm during gastrulation. Expression then declines rapidly after gastrulation, however a small patch of endoderm cells behind the cement gland maintains expression even into tailbud stages.
messages: Interacts (via C-terminus) with ctnnb1/beta-catenin (via Armadillo repeats); this interaction is required for inhibition of wnt-signaling.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription activator. Doesn't appear to bind to the consensus 5'-AACAAT-3' DNA binding site, but binds 5'-ATTGTT-3'. All of the sox17 proteins are required for embryonic endoderm development and gastrulation movements, and show some redundancy in function. In addition, the sox17 proteins have distinct but overlapping roles in later gut development. Acts downstream of vegt-signaling in endoderm differentiation to induce a range of endodermal genes both directly (including endodermin and dhh/chh) and indirectly. Also represses wnt-responsive genes to inhibit wnt/beta-catenin-mediated signaling (By similarity).

8364:LOC116409620
gene id: 8364:LOC116409620
uniprot id: A0A8J1J8L9
names: Subcellular Location Annotation
messages: Membrane

8364:LOC101734580
gene id: 8364:LOC101734580
uniprot id: A0A8J0SEI5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-6 superfamily.
messages: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.
messages: Secreted

8364:hgs
gene id: 8364:hgs
uniprot id: A0A803KIY0
uniprot id: A0A8J0SIR9
uniprot id: A0A8J0SSH0
uniprot id: A0A8J0STG9
uniprot id: A0A8J0STU6
uniprot id: B4F6T1
uniprot id: B7ZUS7
uniprot id: Q28CS1
names: Subcellular Location Annotation
messages: Early endosome membrane

8364:golt1b
gene id: 8364:golt1b
uniprot id: Q5RJU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

8364:LOC100497740
gene id: 8364:LOC100497740
uniprot id: A0A6I8QXK8
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:gjb7
gene id: 8364:gjb7
uniprot id: F6W3E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8364:LOC108645667
gene id: 8364:LOC108645667
uniprot id: A0A8J1JTE2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:canx
gene id: 8364:canx
uniprot id: Q6DK68
names: Similarity
messages: Belongs to the calreticulin family.

8364:LOC100490291
gene id: 8364:LOC100490291
uniprot id: A0A6I8S744
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

8364:pde10a
gene id: 8364:pde10a
uniprot id: A0A6I8RRR8
uniprot id: A0A6I8RY09
uniprot id: A0A6I8SSI8
uniprot id: A0A8J1JJ41
uniprot id: A0A8J1JJ42
uniprot id: A0A8J1JLJ8
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8364:idi1
gene id: 8364:idi1
uniprot id: A0A803KDB9
uniprot id: Q5M8E5
names: Function
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

8364:slco1a2
gene id: 8364:slco1a2
uniprot id: A0A8J1J6A1
uniprot id: A0A8J1J6A3
uniprot id: A0A8J1J6A5
uniprot id: A4IHQ4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:xt6l
gene id: 8364:xt6l
uniprot id: D3WKE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Secreted

8364:eda2r
gene id: 8364:eda2r
uniprot id: A0A8J0QVH7
uniprot id: A0A8J0R1V4
uniprot id: A0A8J0R3T3
uniprot id: A0A8J0T3E2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:anxa13
gene id: 8364:anxa13
uniprot id: F6ZJD3
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

8364:myo5b
gene id: 8364:myo5b
uniprot id: A0A6I8QMP7
uniprot id: A0A6I8SJ57
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:fmo5.2
gene id: 8364:fmo5.2
uniprot id: A0A8J0SL89
uniprot id: Q5EBE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

8364:kcna2
gene id: 8364:kcna2
uniprot id: A0A803K5T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.
messages: Cell membrane
messages: Membrane

8364:polr1e
gene id: 8364:polr1e
uniprot id: B1H209
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

8364:ccne2
gene id: 8364:ccne2
uniprot id: Q28FY3
names: Similarity
messages: Belongs to the cyclin family.

8364:rfng
gene id: 8364:rfng
uniprot id: F6W6M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:tmem33
gene id: 8364:tmem33
uniprot id: A0A8J0PHS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

8364:laptm5
gene id: 8364:laptm5
uniprot id: A0A8J0QGF4
uniprot id: A0A8J1J1R4
uniprot id: B5DFQ0
uniprot id: Q5EAL5
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

8364:LOC108648138
gene id: 8364:LOC108648138
uniprot id: A0A803K5J5
names: Subcellular Location Annotation
messages: Membrane

8364:rpl22
gene id: 8364:rpl22
uniprot id: B0JZZ5
uniprot id: Q28IL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL22 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

8364:LOC116408610
gene id: 8364:LOC116408610
uniprot id: A0A6I8Q2J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:epha2
gene id: 8364:epha2
uniprot id: Q6DII4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC105947139
gene id: 8364:LOC105947139
uniprot id: B5DDY3
uniprot id: Q28DR4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by pak2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

8364:atxn1l
gene id: 8364:atxn1l
uniprot id: A0A6I8PQD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

8364:glod4
gene id: 8364:glod4
uniprot id: A0A8J0QK80
uniprot id: Q6P332
names: Similarity
messages: Belongs to the glyoxalase I family.

8364:LOC108646269
gene id: 8364:LOC108646269
uniprot id: A0A8J1J861
names: Subcellular Location Annotation
messages: Membrane

8364:cul1
gene id: 8364:cul1
uniprot id: Q1KMU1
names: Similarity
messages: Belongs to the cullin family.

8364:LOC116412368
gene id: 8364:LOC116412368
uniprot id: A0A8J1JZF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:sez6
gene id: 8364:sez6
uniprot id: A0A6I8REI9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:tbx15
gene id: 8364:tbx15
uniprot id: A0A6I8RDF1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8364:foxa1
gene id: 8364:foxa1
uniprot id: Q8AWH1
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in the endoderm of mid-gastrula embryos. At neurula stage, expressed in the notochord and in ciliated cells of the epithelium. During tailbud stages, expressed throughout the endoderm as well as in the notochord and neural floor plate.
messages: Nucleus
messages: Probable transcription factor.

8364:LOC100493121
gene id: 8364:LOC100493121
uniprot id: A0A8J0SD97
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:clk3
gene id: 8364:clk3
uniprot id: Q5I092
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:slc39a13
gene id: 8364:slc39a13
uniprot id: A0A8J0T3E7
uniprot id: F7B0H7
names: Subcellular Location Annotation
messages: Membrane

8364:LOC116408617
gene id: 8364:LOC116408617
uniprot id: A0A8J1J639
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:top1.2
gene id: 8364:top1.2
uniprot id: A0A6I8QI98
uniprot id: A0A8J0QGH0
uniprot id: F6YVL0
uniprot id: L7N3P9
uniprot id: Q0V9D3
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

8364:LOC101732858
gene id: 8364:LOC101732858
uniprot id: A0A8J1IVX3
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

8364:pkib
gene id: 8364:pkib
uniprot id: F6TEF1
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

8364:esf1
gene id: 8364:esf1
uniprot id: A0A8J0SLW3
uniprot id: A0A8J0T3X3
uniprot id: A4QNN2
uniprot id: F7A0S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF1 family.
messages: nucleolus

8364:vsx2
gene id: 8364:vsx2
uniprot id: A0A8J0QU38
uniprot id: A0A8J0R275
uniprot id: A0A8J0R5Z1
uniprot id: A0A8J0R6J2
uniprot id: A0A8J0R6X8
uniprot id: F6TH67
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC116409625
gene id: 8364:LOC116409625
uniprot id: A0A8J1J8M4
names: Subcellular Location Annotation
messages: Membrane

8364:ezh1
gene id: 8364:ezh1
uniprot id: A0A6I8R8E5
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100494334
gene id: 8364:LOC100494334
uniprot id: F6ZM74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:lpin2
gene id: 8364:lpin2
uniprot id: A0A6I8QKB0
uniprot id: A0A8J0SGM3
uniprot id: A0A8J0SQ61
uniprot id: Q0P4P7
names: Similarity
messages: Belongs to the lipin family.

8364:hps5
gene id: 8364:hps5
uniprot id: A0A6I8RE31
uniprot id: A1L0Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPS5 family.
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: cytosol

8364:chd9
gene id: 8364:chd9
uniprot id: A0A803KGR2
uniprot id: A0A8J0QHJ9
uniprot id: A0A8J1JDR3
uniprot id: A0A8J1JDR7
uniprot id: A0A8J1JDS0
uniprot id: A0A8J1JDS2
uniprot id: A0A8J1JG92
uniprot id: F6VR24
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

8364:psmb5
gene id: 8364:psmb5
uniprot id: A0A6I8R356
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

8364:map4k5
gene id: 8364:map4k5
uniprot id: A0A8J0SKE8
uniprot id: A0A8J0SV23
uniprot id: B4F6N7
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

8364:LOC108644495
gene id: 8364:LOC108644495
uniprot id: A0A6I8PYY4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:tmprss2.4
gene id: 8364:tmprss2.4
uniprot id: A0A8J1J3G1
uniprot id: A0A8J1J6V7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC105947815
gene id: 8364:LOC105947815
uniprot id: A0A8J0SRJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:ltn1
gene id: 8364:ltn1
uniprot id: A0JM49
uniprot id: F6U7I8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTN1 family.
messages: Component of the ribosome quality control complex (RQC), composed of at least the E3 ubiquitin ligase LTN1 and NEMF associated with the 60S ribosomal subunit. The complex probably also contains TCF25 as well as VCP/p97 and its ubiquitin-binding cofactors.
messages: Component of the ribosome quality control complex (RQC).
messages: E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Within the RQC complex, LTN1 is recruited to stalled 60S ribosomal subunits by NEMF and mediates ubiquitination of stalled nascent chains (By similarity). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity).
messages: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
messages: cytosol

8364:LOC100145428
gene id: 8364:LOC100145428
uniprot id: A0A8J0QM19
names: Subcellular Location Annotation
messages: Membrane

8364:fzd9
gene id: 8364:fzd9
uniprot id: A0A803JUS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Membrane

8364:rps19bp1
gene id: 8364:rps19bp1
uniprot id: Q28IC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AROS family.
messages: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Acts as a chaperone that specifically mediates the integration of RPS19 in state post-A1. Direct regulator of SIRT1.
messages: nucleolus

8364:LOC100496623
gene id: 8364:LOC100496623
uniprot id: A0A803JFN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100486940
gene id: 8364:LOC100486940
uniprot id: A0A8J1JVQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:gpr132
gene id: 8364:gpr132
uniprot id: B1H1F0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:mnd1
gene id: 8364:mnd1
uniprot id: A0A8J0SJP5
uniprot id: Q5FV93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MND1 family.
messages: Nucleus
messages: Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.

8364:kcnk2
gene id: 8364:kcnk2
uniprot id: A0A803K7I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

8364:aasdh
gene id: 8364:aasdh
uniprot id: A0A6I8Q471
uniprot id: A0A8J0R0F8
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

8364:pou5f3.1
gene id: 8364:pou5f3.1
uniprot id: F6TLT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

8364:aff3
gene id: 8364:aff3
uniprot id: A0A8J1J4R5
uniprot id: A0A8J1J4S4
names: Similarity
messages: Belongs to the AF4 family.

8364:ak3
gene id: 8364:ak3
uniprot id: A0A7D9NMI8
uniprot id: A0A8J0S7N1
uniprot id: B3DL17
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion matrix
messages: Monomer.

8364:scrn1
gene id: 8364:scrn1
uniprot id: F7BVR6
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

8364:csnk1g3
gene id: 8364:csnk1g3
uniprot id: A0A6I8PY01
uniprot id: A0A6I8R6G6
uniprot id: A0A8J0SEB2
uniprot id: B6ID06
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

8364:pex5
gene id: 8364:pex5
uniprot id: A0A6I8SLS9
uniprot id: A0A8J0STC5
uniprot id: F7EDC2
uniprot id: Q5M7M1
names: Similarity
messages: Belongs to the peroxisomal targeting signal receptor family.

8364:cspg4
gene id: 8364:cspg4
uniprot id: F6UZL8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:fshb
gene id: 8364:fshb
uniprot id: A0A803JNQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

8364:l3hypdh
gene id: 8364:l3hypdh
uniprot id: Q66II5
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the proline racemase family.
messages: Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C).
messages: Homodimer.
messages: In contrast to the T.cruzi proline racemase enzyme, lacks the conserved Cys at position 267 which is replaced by a Thr residue, transforming the racemase activity into dehydratase activity.

8364:LOC100485637
gene id: 8364:LOC100485637
uniprot id: A0A6I8SD69
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:sncb
gene id: 8364:sncb
uniprot id: Q6PBD9
names: Similarity
messages: Belongs to the synuclein family.

8364:rybp
gene id: 8364:rybp
uniprot id: F6TN18
uniprot id: Q28DL7
names: Subcellular Location Annotation
messages: Nucleus

8364:rnf182
gene id: 8364:rnf182
uniprot id: A4IHL7
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with ATP6V0C.
messages: Membrane

8364:zcchc8
gene id: 8364:zcchc8
uniprot id: A0A8J0SDI3
uniprot id: B4F702
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZCCHC8 family.
messages: nucleoplasm

8364:LOC100170490
gene id: 8364:LOC100170490
uniprot id: F6SU60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

8364:hcfc2
gene id: 8364:hcfc2
uniprot id: A0A6I8RLL6
uniprot id: A0A8J0R2R1
names: Subcellular Location Annotation
messages: Nucleus

8364:sult6b1.4
gene id: 8364:sult6b1.4
uniprot id: F7A3C3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8364:ctif
gene id: 8364:ctif
uniprot id: Q0V9S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTIF family.
messages: Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD) (By similarity).
messages: perinuclear region

8364:LOC100498433
gene id: 8364:LOC100498433
uniprot id: A0A803KA71
uniprot id: A0A8J1J4J5
uniprot id: A0A8J1J7Z4
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

8364:ctsa
gene id: 8364:ctsa
uniprot id: A0A8J0S9F9
uniprot id: F7CZL3
uniprot id: Q28C48
names: Similarity
messages: Belongs to the peptidase S10 family.

8364:clp1
gene id: 8364:clp1
uniprot id: Q66JK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of the tRNA splicing endonuclease complex. Component of pre-mRNA cleavage complex II (CF-II).
messages: Nucleus
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Its role in tRNA splicing and maturation is required for cerebellar development. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by dicer1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing (By similarity).

8364:ccdc69
gene id: 8364:ccdc69
uniprot id: Q0IHN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC69 family.
messages: May act as a scaffold to regulate the recruitment and assembly of spindle midzone components.
messages: Midbody
messages: spindle

8364:LOC100487329
gene id: 8364:LOC100487329
uniprot id: A0A8J1J2V6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:adhfe1
gene id: 8364:adhfe1
uniprot id: A0A803KIE3
uniprot id: A0A8J1JQ50
uniprot id: Q6P371
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity).
messages: Mitochondrion

8364:tgfbr2
gene id: 8364:tgfbr2
uniprot id: F6U8C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane
messages: Membrane raft

8364:abcd2
gene id: 8364:abcd2
uniprot id: A0A6I8R1K6
names: Subcellular Location Annotation
messages: Membrane

8364:prdm13
gene id: 8364:prdm13
uniprot id: A0A6I8PSL5
names: Subcellular Location Annotation
messages: Nucleus

8364:adrb1
gene id: 8364:adrb1
uniprot id: A0A8J0QM79
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:c8h9orf116
gene id: 8364:c8h9orf116
uniprot id: A0A803K4C5
uniprot id: A0A8J1IQZ6
names: Subcellular Location Annotation
messages: cilium axoneme

8364:agmo
gene id: 8364:agmo
uniprot id: Q5M8F9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family. TMEM195 subfamily.
messages: Endoplasmic reticulum membrane
messages: Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes (By similarity).

8364:cct6a
gene id: 8364:cct6a
uniprot id: Q6NVT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

8364:cand2
gene id: 8364:cand2
uniprot id: A0A6I8SW24
uniprot id: A0A8J0SCQ1
names: Similarity
messages: Belongs to the CAND family.

8364:LOC100127682
gene id: 8364:LOC100127682
uniprot id: A8WGF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8364:gja10
gene id: 8364:gja10
uniprot id: A0A8J0T454
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8364:tfdp1
gene id: 8364:tfdp1
uniprot id: Q5M8Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

8364:LOC100490508
gene id: 8364:LOC100490508
uniprot id: A0A6I8PNG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

8364:chmp7
gene id: 8364:chmp7
uniprot id: A0A8J0SFF9
uniprot id: Q5FW14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF7 family.
messages: Cytoplasm
messages: ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway.
messages: Nucleus envelope

8364:wdr76
gene id: 8364:wdr76
uniprot id: A0A8J0QJL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Interacts with CUL4A and/or CUL4B.
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

8364:LOC101734669
gene id: 8364:LOC101734669
uniprot id: A0A8J1J5X3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:e2f7
gene id: 8364:e2f7
uniprot id: A0A5S6MB18
uniprot id: A0A8J0QXT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

8364:prkd1
gene id: 8364:prkd1
uniprot id: B2GU99
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

8364:psmg1
gene id: 8364:psmg1
uniprot id: A4IHY1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PSMG1 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.
messages: Cytoplasm
messages: Degraded by the proteasome upon completion of 20S proteasome maturation.
messages: Endoplasmic reticulum
messages: Forms a heterodimer with psmg2.

8364:nkx2-6
gene id: 8364:nkx2-6
uniprot id: F7EU05
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC101733314
gene id: 8364:LOC101733314
uniprot id: A0A803J723
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

8364:rin2
gene id: 8364:rin2
uniprot id: A0A803K8U5
uniprot id: A0A8J0STP3
uniprot id: A0A8J0T0P8
uniprot id: B1WAT0
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

8364:htr1b
gene id: 8364:htr1b
uniprot id: F7CKP0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homodimer. Heterodimer with HTR1D.
messages: Membrane

8364:cry4
gene id: 8364:cry4
uniprot id: A0A6I8QG66
uniprot id: B3DL51
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 FAD per subunit.

8364:tmprss2.6
gene id: 8364:tmprss2.6
uniprot id: A0A6I8QZ09
uniprot id: A0A8J1J6W2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC100485036
gene id: 8364:LOC100485036
uniprot id: A0A8J0QT67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100486150
gene id: 8364:LOC100486150
uniprot id: F7C6D9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:cstf3
gene id: 8364:cstf3
uniprot id: Q6P4J1
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC101732030
gene id: 8364:LOC101732030
uniprot id: A0A8J0T4H9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:stac2
gene id: 8364:stac2
uniprot id: A0A8J1J1I0
uniprot id: F7EAC8
names: Subcellular Location Annotation
messages: sarcolemma

8364:calhm5
gene id: 8364:calhm5
uniprot id: A0A803KFN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

8364:btg5.2
gene id: 8364:btg5.2
uniprot id: B0JZ08
uniprot id: Q4VA81
names: Similarity
messages: Belongs to the BTG family.

8364:patl2
gene id: 8364:patl2
uniprot id: B5DEB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PAT1 family.
messages: Cytoplasm
messages: Interacts with ribonucleoprotein complex components. Interacts with cpeb (By similarity).
messages: Nucleus
messages: RNA-binding protein that acts as a translational repressor.

8364:vma21
gene id: 8364:vma21
uniprot id: Q28GR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VMA21 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.

8364:uhrf2
gene id: 8364:uhrf2
uniprot id: A4IH62
uniprot id: F7ESL3
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.
messages: Nucleus
messages: The YDG domain mediates the interaction with histone H3.
messages: The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3).

8364:pclo
gene id: 8364:pclo
uniprot id: A0A6I8Q0Z4
uniprot id: A0A6I8S477
uniprot id: A0A6I8SIJ8
uniprot id: A0A8J1JAJ1
uniprot id: A0A8J1JAJ3
uniprot id: A0A8J1JAK1
names: Subcellular Location Annotation
messages: Presynaptic active zone

8364:hspb7
gene id: 8364:hspb7
uniprot id: B2GUG1
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

8364:kiz
gene id: 8364:kiz
uniprot id: A0A6I8RL46
uniprot id: A0A6I8SGD0
uniprot id: A0A8J0SPT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kizuna family.
messages: Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.
messages: centrosome
messages: cilium basal body

8364:LOC100490956
gene id: 8364:LOC100490956
uniprot id: A0A8J0QU31
uniprot id: A0A8J1JBN3
names: Similarity
messages: Belongs to the aldo/keto reductase family.

8364:LOC100485054
gene id: 8364:LOC100485054
uniprot id: A0A803JH23
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:egflam
gene id: 8364:egflam
uniprot id: A0A6I8R2I9
uniprot id: A0A8J1J055
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:dact1
gene id: 8364:dact1
uniprot id: Q66KC9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dapper family.
messages: Cytoplasm
messages: Interacts with dbf4, dvl2 and tcf7l1.
messages: Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. Binds to dvl2 and regulates the degradation of ctnnb1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. May also bind to and directly stimulate the activity of tcf7l1 (By similarity).
messages: Nucleus
messages: The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins.

8364:dph2
gene id: 8364:dph2
uniprot id: A0A803KF36
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.

8364:llgl2
gene id: 8364:llgl2
uniprot id: A4II87
uniprot id: Q5EGD5
names: Similarity
messages: Belongs to the WD repeat L(2)GL family.

8364:pigs
gene id: 8364:pigs
uniprot id: A8E4X4
uniprot id: F7C443
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGS family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:LOC116409584
gene id: 8364:LOC116409584
uniprot id: A0A8J1J8H6
names: Subcellular Location Annotation
messages: Membrane

8364:LOC116411743
gene id: 8364:LOC116411743
uniprot id: A0A8J1JRC2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:syk
gene id: 8364:syk
uniprot id: A0A6I8RKY0
uniprot id: F7DXJ8
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.

8364:smagp
gene id: 8364:smagp
uniprot id: B0JZR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAGP family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane

8364:rdh16
gene id: 8364:rdh16
uniprot id: A9ULC8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8364:LOC108648865
gene id: 8364:LOC108648865
uniprot id: F7C6D9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:mlh1
gene id: 8364:mlh1
uniprot id: A0A8J0QND8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

8364:LOC116407767
gene id: 8364:LOC116407767
uniprot id: A0A803KFH5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

8364:ptgs2
gene id: 8364:ptgs2
uniprot id: Q501R2
names: Caution
names: Similarity
messages: Belongs to the prostaglandin G/H synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:calcrl
gene id: 8364:calcrl
uniprot id: A0A6I8T0S3
uniprot id: A0A803K353
uniprot id: A0A810QKG9
uniprot id: Q0P4Y4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for calcitonin-gene-related peptide (CGRP) (By similarity). Receptor specificity may be modulated by accessory proteins. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).
messages: Receptor for calcitonin-gene-related peptide (CGRP). Receptor specificity may be modulated by accessory proteins. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

8364:cltb
gene id: 8364:cltb
uniprot id: A0A803JHX4
uniprot id: Q5XGH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

8364:bcl7b
gene id: 8364:bcl7b
uniprot id: A4QNP6
names: Similarity
messages: Belongs to the BCL7 family.

8364:gadl1
gene id: 8364:gadl1
uniprot id: A0A6I8RRP5
uniprot id: A0A8J1JN20
uniprot id: Q28D99
names: Function
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is L-aspartate. Does not exhibit any decarboxylation activity toward glutamate.
messages: Homodimer.

8364:cxcl2
gene id: 8364:cxcl2
uniprot id: A0A1B8Y8M9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Homodimer.
messages: Secreted

8364:arpin
gene id: 8364:arpin
uniprot id: A0A8J0SGY4
uniprot id: Q6DJ71
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the Arp2/3 complex.
messages: Belongs to the Arpin family.
messages: Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors. Involved in steering cell migration by controlling its directional persistence (By similarity).
messages: The acidic C-terminus is necessary and sufficient to inhibit ARP2/3 complex activity.
messages: lamellipodium

8364:lipt2
gene id: 8364:lipt2
uniprot id: Q0VFH3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes, which catalyze essential redox reactions (By similarity). Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity).
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.
messages: Mitochondrion

8364:t2r5
gene id: 8364:t2r5
uniprot id: Q2AB76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:lipt1
gene id: 8364:lipt1
uniprot id: A8WH00
uniprot id: F6RNJ0
names: Similarity
messages: Belongs to the LplA family.

8364:cldn11
gene id: 8364:cldn11
uniprot id: A0A803J6U8
uniprot id: A0A803JPF5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8364:LOC100491382
gene id: 8364:LOC100491382
uniprot id: A0A803KFQ9
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

8364:LOC105945565
gene id: 8364:LOC105945565
uniprot id: A0A8J0S616
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:abhd17c
gene id: 8364:abhd17c
uniprot id: Q6GL10
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. ABHD17 family.
messages: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins.
messages: Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization.
messages: Postsynaptic density membrane
messages: Recycling endosome membrane
messages: dendritic spine

8364:c18orf21
gene id: 8364:c18orf21
uniprot id: A0A803JGG8
uniprot id: A4IIB4
names: Similarity
messages: Belongs to the UPF0711 family.

8364:LOC116411580
gene id: 8364:LOC116411580
uniprot id: A0A8J1JTN8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:rab9a
gene id: 8364:rab9a
uniprot id: Q05AZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: phagosome membrane

8364:lrp8
gene id: 8364:lrp8
uniprot id: A0A6I8RBJ5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:MGC89221
gene id: 8364:MGC89221
uniprot id: A0A803KGN3
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

8364:umodl1
gene id: 8364:umodl1
uniprot id: A0A6I8PQ09
uniprot id: A0A8J0S6A1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC116411010
gene id: 8364:LOC116411010
uniprot id: A0A8J1JL76
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:cask
gene id: 8364:cask
uniprot id: A0A6I8RIJ2
uniprot id: A0A6I8T1N5
uniprot id: A0A8J0SFH7
uniprot id: A0A8J1J1U7
uniprot id: A0A8J1J1V0
uniprot id: A0A8J1J1V6
uniprot id: A0A8J1J486
uniprot id: F6UGQ3
uniprot id: Q28CJ8
names: Similarity
messages: Belongs to the MAGUK family.

8364:cdk17
gene id: 8364:cdk17
uniprot id: A0A8J0SHF5
uniprot id: F6Z6S8
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC100493185
gene id: 8364:LOC100493185
uniprot id: A0A8J0SH68
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:tead1
gene id: 8364:tead1
uniprot id: A0A803J2U9
uniprot id: A0A803JP88
uniprot id: A0A803JUS0
uniprot id: A0A803K5Y2
uniprot id: A0A8J1JEG7
uniprot id: A0A8J1JEH0
uniprot id: A0A8J1JEH5
uniprot id: A0A8J1JEH6
uniprot id: A0A8J1JHZ0
names: Subcellular Location Annotation
messages: Nucleus

8364:fam102a
gene id: 8364:fam102a
uniprot id: A0JM34
names: Similarity
messages: Belongs to the EEIG family.

8364:slc39a7
gene id: 8364:slc39a7
uniprot id: A0A7D9NJU8
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100487968
gene id: 8364:LOC100487968
uniprot id: A0A8J0SE11
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:faah.2
gene id: 8364:faah.2
uniprot id: F6PSQ8
names: Similarity
messages: Belongs to the amidase family.

8364:LOC105946738
gene id: 8364:LOC105946738
uniprot id: A0A8J1J939
names: Similarity
messages: Belongs to the dermatopontin family.

8364:wtap
gene id: 8364:wtap
uniprot id: A0A8J1JHW6
uniprot id: F7BUP7
uniprot id: Q6P4K5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing.
messages: Belongs to the fl(2)d family.
messages: Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM. Component of the MACOM subcomplex.
messages: Nucleus speckle
messages: nucleoplasm

8364:aldh16a1
gene id: 8364:aldh16a1
uniprot id: Q28CF4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

8364:cyp2a6.9
gene id: 8364:cyp2a6.9
uniprot id: Q6DIW7
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:serf2
gene id: 8364:serf2
uniprot id: A0A6I8Q4B0
names: Similarity
messages: Belongs to the SERF family.

8364:coq6
gene id: 8364:coq6
uniprot id: A0A8J1INX0
uniprot id: Q6DF46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiH/COQ6 family.
messages: Cell projection
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ7.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least coq3, coq4, coq5, coq6, coq7 and coq9. Interacts with coq8b and coq7.
messages: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
messages: Golgi apparatus
messages: Mitochondrion inner membrane

8364:LOC100491410
gene id: 8364:LOC100491410
uniprot id: A0A8J1J2Q1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:chst12
gene id: 8364:chst12
uniprot id: Q28E26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:csf1r
gene id: 8364:csf1r
uniprot id: Q640T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

8364:LOC733726
gene id: 8364:LOC733726
uniprot id: Q6GLC4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:zc3h15
gene id: 8364:zc3h15
uniprot id: A0A4X2QBT9
uniprot id: A4IGY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZC3H15/TMA46 family.
messages: Cytoplasm
messages: Interacts with drg1.
messages: Nucleus
messages: Protects drg1 from proteolytic degradation.

8364:ciapin1
gene id: 8364:ciapin1
uniprot id: A4IHR0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Monomer. Interacts with ndor1. Interacts with chchd4.
messages: Nucleus
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

8364:man1a2
gene id: 8364:man1a2
uniprot id: F6ZWF3
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

8364:wapl
gene id: 8364:wapl
uniprot id: A0A8J0QSX6
names: Similarity
messages: Belongs to the WAPL family.

8364:ccn6
gene id: 8364:ccn6
uniprot id: A0A8J0QMX1
uniprot id: A0A8J1JLV9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:slc2a9
gene id: 8364:slc2a9
uniprot id: A0A6I8S2W0
uniprot id: F6UC71
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

8364:pdxk
gene id: 8364:pdxk
uniprot id: A0A6I8RNG5
uniprot id: A0JLY9
names: Similarity
messages: Belongs to the pyridoxine kinase family.

8364:ldb2
gene id: 8364:ldb2
uniprot id: A0A6I8SFW8
uniprot id: A0A6I8T2L9
names: Similarity
messages: Belongs to the LDB family.

8364:spock2
gene id: 8364:spock2
uniprot id: A0A803JQ85
uniprot id: F7E3Y0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:glra3
gene id: 8364:glra3
uniprot id: A0A803JBM6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

8364:foxn3
gene id: 8364:foxn3
uniprot id: A0A8J0SW28
uniprot id: A0JPB6
uniprot id: B1H110
uniprot id: Q28G71
names: Function
names: Subcellular Location Annotation
messages: Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints) (By similarity).
messages: Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).
messages: Nucleus

8364:psma3
gene id: 8364:psma3
uniprot id: Q5PPP6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

8364:cutc
gene id: 8364:cutc
uniprot id: A0A6I8R4D6
uniprot id: A0A6I8SBH7
uniprot id: Q5M8Y5
names: Similarity
messages: Belongs to the CutC family.

8364:me1
gene id: 8364:me1
uniprot id: A0A6I8S9Q0
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

8364:hes4
gene id: 8364:hes4
uniprot id: Q6PBD4
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
messages: Nucleus
messages: The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins. The WPRW motif is also required for the inductive function, independent of transcription regulation activity (By similarity).
messages: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family. Interacts with the bHLH protein hes6; this interaction may inhibit the transcriptional repressor activity. Binds DNA in the form of a heterodimer with the bHLH protein hey1/hrt1. Interacts (via Orange domain) with id3 (via HLH domain) (By similarity).
messages: Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'. Promotes floor plate development and prechordal plate development. Required for lens development as early as the stage of lens field formation, partly through regulation of gene expression of the cell cycle inhibitor cdknx/p27(xic1). Required for formation of the neural crest downstream of multiple signaling pathways, and acts at the neural plate border via both DNA-binding dependent and independent mechanisms. Also acts via repressor-dependent and repressor-independent mechanisms in early gastrulae to establish the prospective anterior prechordal mesoderm identity in the Spemann organizer; induces specific genes independently from direct transcriptional regulation, and represses the genes specific for neighboring tissues through direct transcriptional repression. Modulates lateral inhibition during notch signaling and regulates the cell context dependent effects of notch (which can have inhibitory, permissive or enhancing roles in muscle or neural differentiation). Inhibits myogenesis (By similarity).

8364:LOC100135138
gene id: 8364:LOC100135138
uniprot id: A9JSD4
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

8364:borcs5
gene id: 8364:borcs5
uniprot id: A0A1B8Y9B6
uniprot id: A8E5U3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As part of a BORC-like complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, this complex may couple lysosomes to microtubule plus-end-directed kinesin motor.
messages: Belongs to the BORCS5 family.
messages: Lysosome membrane
messages: Membrane

8364:lin7b
gene id: 8364:lin7b
uniprot id: A0A803JE30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-7 family.
messages: Cell junction
messages: Cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.

8364:gpr6
gene id: 8364:gpr6
uniprot id: A0A6I8PY67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC101733960
gene id: 8364:LOC101733960
uniprot id: A0A8J1J2L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

8364:LOC116408758
gene id: 8364:LOC116408758
uniprot id: A0A8J1J716
names: Subcellular Location Annotation
messages: Membrane

8364:ca5b
gene id: 8364:ca5b
uniprot id: A0A6I8RDI3
uniprot id: Q28BX3
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

8364:LOC100490015
gene id: 8364:LOC100490015
uniprot id: A0A8J0QMD1
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:maml3
gene id: 8364:maml3
uniprot id: A0A6I8Q1E9
uniprot id: A0A8J0R0R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mastermind family.
messages: Nucleus speckle

8364:tek
gene id: 8364:tek
uniprot id: A0A6I8T2P4
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:slc25a47
gene id: 8364:slc25a47
uniprot id: F6VSR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8364:trmu
gene id: 8364:trmu
uniprot id: A0A6I8QH09
uniprot id: A0A8J1JAG0
names: Function
names: Similarity
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.

8364:bdh1
gene id: 8364:bdh1
uniprot id: F6RPF1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8364:glrx3
gene id: 8364:glrx3
uniprot id: Q28ID3
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer; the homodimer is independent of 2Fe-2S clusters. Heterotrimer; forms a heterotrimeric complex composed by two bola2 molecules and one glrx3 molecule; linked by [2Fe-2S] clusters.
messages: The thioredoxin domain lacks the two redox-active cysteines. This strongly suggests that it lacks thioredoxin activity.
messages: Together with bola2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.
messages: cytosol

8364:dock10
gene id: 8364:dock10
uniprot id: A0A8J1JK48
uniprot id: A0A8J1JK51
uniprot id: A0A8J1JK52
uniprot id: A0A8J1JK56
uniprot id: A0A8J1JMJ6
uniprot id: A0A8J1JNS0
uniprot id: A0A8J1JNS5
names: Similarity
messages: Belongs to the DOCK family.

8364:atp6v0e2
gene id: 8364:atp6v0e2
uniprot id: A4IH67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

8364:slc4a7
gene id: 8364:slc4a7
uniprot id: A0A6I8SE97
uniprot id: A0A6I8T241
uniprot id: A0A7D9NL69
uniprot id: A0A8J0SH87
uniprot id: A0A8J0SP86
uniprot id: A0A8J1JPG7
uniprot id: A0A8J1JPG9
uniprot id: A0A8J1JPH2
uniprot id: A0A8J1JPH4
uniprot id: A0A8J1JRZ9
uniprot id: A0A8J1JT76
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

8364:plk4
gene id: 8364:plk4
uniprot id: A0A8J0SFJ5
uniprot id: B3DL84
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Homodimer.
messages: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as sass6, cenpj/cpap, ccp110, cep135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity).
messages: Ubiquitinated; leading to its degradation by the proteasome.
messages: centriole
messages: centrosome

8364:nek8
gene id: 8364:nek8
uniprot id: A0A803KLH8
uniprot id: A0A8J1J3Z5
uniprot id: A0A8J1J4Z7
uniprot id: F6VA07
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

8364:dis3l
gene id: 8364:dis3l
uniprot id: Q0P4R5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNR ribonuclease family.
messages: Component of the RNA exosome complex.
messages: Cytoplasm
messages: Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.

8364:LOC100491826
gene id: 8364:LOC100491826
uniprot id: A0A803JZ08
uniprot id: A0A803K9K7
uniprot id: A0A8J0QZN8
uniprot id: A0A8J0SF23
uniprot id: A0A8J0SPP3
uniprot id: A0A8J1JM77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-H/MCM16 family.
messages: Nucleus
messages: kinetochore

8364:map3k10
gene id: 8364:map3k10
uniprot id: A0A6I8QJK6
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

8364:prmt5
gene id: 8364:prmt5
uniprot id: F6WH46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Nucleus

8364:LOC116412356
gene id: 8364:LOC116412356
uniprot id: A0A8J1JWT9
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:LOC100494298
gene id: 8364:LOC100494298
uniprot id: A0A8J1JBV9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC116408612
gene id: 8364:LOC116408612
uniprot id: A0A8J1J2N5
names: Subcellular Location Annotation
messages: Membrane

8364:tmem186
gene id: 8364:tmem186
uniprot id: A0A6I8QWJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM186 family.
messages: Membrane

8364:abcg8
gene id: 8364:abcg8
uniprot id: A0A8J1JPE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

8364:wac
gene id: 8364:wac
uniprot id: Q5U4Q0
names: Function
names: Subcellular Location Annotation
messages: Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Positive regulator of amino acid starvation-induced autophagy. Positively regulates MTOR activity. May negatively regulate the ubiquitin proteasome pathway.
messages: Nucleus

8364:nos3
gene id: 8364:nos3
uniprot id: E8Z914
uniprot id: F6VMJ0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.

8364:mogat3
gene id: 8364:mogat3
uniprot id: F6ZJR8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:paics.1
gene id: 8364:paics.1
uniprot id: A0A6I8SSC3
uniprot id: A0A803JC09
uniprot id: A0A8J0R0U7
uniprot id: A0A8J0SCV8
uniprot id: A0A8J1J096
names: Similarity
names: Subunit
messages: Homooctamer.
messages: In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.
messages: In the N-terminal section; belongs to the SAICAR synthetase family.

8364:tmem214
gene id: 8364:tmem214
uniprot id: A0A803KFD3
uniprot id: A0A8J1JIS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM214 family.
messages: Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.
messages: Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:LOC116409811
gene id: 8364:LOC116409811
uniprot id: A0A1B8XZW2
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:LOC116410219
gene id: 8364:LOC116410219
uniprot id: A0A8J1JHN6
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:pcyt2
gene id: 8364:pcyt2
uniprot id: A0A6I8Q380
uniprot id: F7CXF7
names: Similarity
messages: Belongs to the cytidylyltransferase family.

8364:pdyn
gene id: 8364:pdyn
uniprot id: A0A803K251
names: Similarity
messages: Belongs to the opioid neuropeptide precursor family.

8364:slc27a2
gene id: 8364:slc27a2
uniprot id: A0A8J0QWD8
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

8364:sgsh
gene id: 8364:sgsh
uniprot id: B0BML2
names: Similarity
messages: Belongs to the sulfatase family.

8364:LOC105945734
gene id: 8364:LOC105945734
uniprot id: A0A8J1JHD8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:arhgef7
gene id: 8364:arhgef7
uniprot id: A0A6I8RQF4
uniprot id: A0A8J0R0Y5
uniprot id: A0A8J0S8J7
names: Subcellular Location Annotation
messages: lamellipodium

8364:eftud2
gene id: 8364:eftud2
uniprot id: Q5BL79
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC101731839
gene id: 8364:LOC101731839
uniprot id: A0A8J1ITM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:abracl
gene id: 8364:abracl
uniprot id: A0A6I8S2R4
uniprot id: A4IHJ3
names: Similarity
messages: Belongs to the costars family.

8364:adh7
gene id: 8364:adh7
uniprot id: A0A8J0QK75
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

8364:clpp
gene id: 8364:clpp
uniprot id: F6WLE7
names: Similarity
messages: Belongs to the peptidase S14 family.

8364:map3k5
gene id: 8364:map3k5
uniprot id: A0A6I8QHY6
uniprot id: A0A6I8SW78
uniprot id: A0A8J0SEZ3
uniprot id: F7A415
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

8364:c1d
gene id: 8364:c1d
uniprot id: A0A6I8PUJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the C1D family.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
messages: nucleolus

8364:LOC108646266
gene id: 8364:LOC108646266
uniprot id: A0A8J0T2Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:slc18b1
gene id: 8364:slc18b1
uniprot id: B7ZU34
uniprot id: Q07G00
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100488258
gene id: 8364:LOC100488258
uniprot id: A0A8J0SEH6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:rhot1
gene id: 8364:rhot1
uniprot id: A0A6I8R4Y7
uniprot id: A0A6I8RI68
uniprot id: A0A8J1IX87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrion outer membrane

8364:eif5a
gene id: 8364:eif5a
uniprot id: Q6DK71
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.

8364:aspm
gene id: 8364:aspm
uniprot id: F6URN1
names: Subcellular Location Annotation
messages: Nucleus

8364:plscr4
gene id: 8364:plscr4
uniprot id: A0A6I8SNA7
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

8364:cdh8
gene id: 8364:cdh8
uniprot id: F6SF63
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane

8364:mtg1
gene id: 8364:mtg1
uniprot id: A9JTX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Mitochondrion inner membrane
messages: Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity (By similarity). Displays mitochondrial GTPase activity (By similarity).

8364:gucy1a1
gene id: 8364:gucy1a1
uniprot id: A0A6I8PSI8
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

8364:LOC100494498
gene id: 8364:LOC100494498
uniprot id: A0A8J1IMM7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:slc16a1
gene id: 8364:slc16a1
uniprot id: Q28CH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

8364:tulp4
gene id: 8364:tulp4
uniprot id: A0A6I8RF55
uniprot id: A9JRM4
names: Similarity
messages: Belongs to the TUB family.

8364:krt19
gene id: 8364:krt19
uniprot id: A0A6I8QW47
uniprot id: Q6P7K6
names: Similarity
messages: Belongs to the intermediate filament family.

8364:epdr1
gene id: 8364:epdr1
uniprot id: F6VRB7
names: Similarity
messages: Belongs to the ependymin family.

8364:gpr87
gene id: 8364:gpr87
uniprot id: A0A803JW62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:mmp16
gene id: 8364:mmp16
uniprot id: A0A6I8SSD4
uniprot id: F7BXA2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

8364:LOC100490275
gene id: 8364:LOC100490275
uniprot id: A0A8J1JA94
names: Similarity
messages: Belongs to the CRISP family.

8364:mmd
gene id: 8364:mmd
uniprot id: A0A6I8Q1P8
uniprot id: F6PP89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

8364:LOC100497930
gene id: 8364:LOC100497930
uniprot id: A0A8J0QIW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC101734361
gene id: 8364:LOC101734361
uniprot id: A0A8J0R8H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC116412346
gene id: 8364:LOC116412346
uniprot id: A0A8J1JWS1
names: Subcellular Location Annotation
messages: Membrane

8364:timeless
gene id: 8364:timeless
uniprot id: A0A6I8PXH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the timeless family.
messages: Nucleus

8364:LOC100485985
gene id: 8364:LOC100485985
uniprot id: A0A8J1ISB0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:plcg1
gene id: 8364:plcg1
uniprot id: F6Z8A1
names: Function
messages: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

8364:e2f6
gene id: 8364:e2f6
uniprot id: A0A6I8STE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

8364:copg1
gene id: 8364:copg1
uniprot id: Q6P4J2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

8364:galnt14
gene id: 8364:galnt14
uniprot id: A0A803K9T0
uniprot id: Q0V9M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8364:nectin3
gene id: 8364:nectin3
uniprot id: A0A8J0QRR6
names: Similarity
messages: Belongs to the nectin family.

8364:bbox1
gene id: 8364:bbox1
uniprot id: B1WAZ0
names: Function
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.
messages: Catalyzes the formation of L-carnitine from gamma-butyrobetaine.

8364:pitpnc1
gene id: 8364:pitpnc1
uniprot id: Q28CA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIB subfamily.
messages: Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidic acid (PA) between membranes (By similarity). Binds PA derived from the phospholipase D signaling pathway and among the cellular PA species, preferably binds to the C16:0/16:1 and C16:1/18:1 PA species (By similarity).
messages: Cytoplasm

8364:shank1
gene id: 8364:shank1
uniprot id: A0A8J1JYC3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Postsynaptic density

8364:exoc3
gene id: 8364:exoc3
uniprot id: Q6DJR6
names: Similarity
messages: Belongs to the SEC6 family.

8364:noxred1
gene id: 8364:noxred1
uniprot id: A0JM24
names: Function
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Probable oxidoreductase.

8364:LOC105945564
gene id: 8364:LOC105945564
uniprot id: A0A8J0T256
names: Subcellular Location Annotation
messages: Membrane

8364:kcnk3
gene id: 8364:kcnk3
uniprot id: A0A803JZK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

8364:thrb
gene id: 8364:thrb
uniprot id: B3GR08
uniprot id: E7CYG2
uniprot id: E7CYG4
uniprot id: Q0EDH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

8364:cebpb
gene id: 8364:cebpb
uniprot id: Q3SYP1
names: Similarity
messages: Belongs to the bZIP family. C/EBP subfamily.

8364:nubpl
gene id: 8364:nubpl
uniprot id: Q0P4L5
names: Similarity
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.

8364:npsr1
gene id: 8364:npsr1
uniprot id: A0A6I8Q3X7
uniprot id: A0A8J1JR15
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:gcat
gene id: 8364:gcat
uniprot id: Q6P313
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

8364:tspan1
gene id: 8364:tspan1
uniprot id: Q28F80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8364:kcnj15
gene id: 8364:kcnj15
uniprot id: A0A803J9B2
uniprot id: F6SPD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

8364:hes1
gene id: 8364:hes1
uniprot id: Q5PPM5
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
messages: Nucleus
messages: The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
messages: The bHLH, as well as cooperation between the central Orange domain and the C-terminal WRPW motif, is required for transcriptional repressor activity.
messages: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family. Interacts with the bHLH protein hes2, and binds DNA in the form of a heterodimer with the bHLH protein hey1/hrt1. Interacts with the bHLH protein hes6; this interaction may inhibit the transcriptional repressor activity (By similarity).
messages: Transcriptional repressor of a subset of early mesodermal genes including myod1 and t/bra. Binds DNA on N-box motifs: 5'-CACNAG-3'. Acts as a negative regulator of myogenesis, mediating Notch signaling to repress expression of myod1 (By similarity).

8364:ccm2l
gene id: 8364:ccm2l
uniprot id: A0A803K409
names: Similarity
messages: Belongs to the CCM2 family.

8364:dyrk1a
gene id: 8364:dyrk1a
uniprot id: A0A6I8QSK6
uniprot id: F6QKT7
uniprot id: Q0IJ08
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autophosphorylated on tyrosine residues.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
messages: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Plays an important role in double-strand breaks (DSBs) repair following DNA damage. Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (By similarity). Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: The histidine-rich domain (HRD) region is intrinsically disordered and promotes the formation of phase-separated liquid droplets that enhance its ability to phosphorylate the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II).

8364:LOC100158544
gene id: 8364:LOC100158544
uniprot id: B2GUB3
names: Caution
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Arg-340 is the main determinant for regioselectivity, which segregates between initiases and elongases in all tubulin--tyrosine ligase family. A glutamine residue at this position is found in elongases TTLL6, TTLL9, TTLL11, TTLL13, TTLL10 and favors glutamate-chain elongation, whereas an arginine residue is found in initiases TTLL2, TTLL4, TTLL5, TTLL3, TTLL8 and favors initiation.
messages: Monoglycylase which modifies alpha- and beta-tubulin, adding a single glycine on the gamma-carboxyl groups of specific glutamate residues to generate monoglycine side chains within the C-terminal tail of tubulin. Not involved in elongation step of the polyglycylation reaction (PubMed:28576883). Preferentially glycylates a beta-tail peptide over the alpha-tail, although shifts its preference toward alpha-tail as beta-tail glutamylation increases (PubMed:28576883). Competes with polyglutamylases for modification site on beta-tubulin substrate, thereby creating an anticorrelation between glycylation and glutamylation reactions (PubMed:28576883). Together with TTLL8, mediates microtubule glycylation of primary and motile cilia, which is essential for their stability and maintenance (By similarity).
messages: TTLL3 and TTLL8 monoglycylase-mediated glycylation of tubulin was initially reported to play a role in ependymal motile ciliary maintenance (By similarity). However, contradictory results were later observed (By similarity).
messages: Two conserved structural elements specific among monoglycylases, IS1 and IS2, are involved in glycyl chains initiation. Two conserved structural interfaces likely constitute the binding platforms for tubulin tail and microtubule.
messages: cilium
messages: cilium axoneme
messages: cytoskeleton
messages: flagellum axoneme

8364:zic4
gene id: 8364:zic4
uniprot id: A0A6I8SSC4
uniprot id: A0A8J1JK94
uniprot id: A0A8J1JK99
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

8364:rps6
gene id: 8364:rps6
uniprot id: Q6P7K2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

8364:gata2
gene id: 8364:gata2
uniprot id: A0A8J0QMR1
uniprot id: F6UN64
names: Subcellular Location Annotation
messages: Nucleus

8364:adamts3
gene id: 8364:adamts3
uniprot id: A0A6I8SHU8
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:eml5
gene id: 8364:eml5
uniprot id: A0A6I8Q1K0
uniprot id: A0A8J1IMB2
names: Function
names: Similarity
messages: Belongs to the WD repeat EMAP family.
messages: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.

8364:churc1
gene id: 8364:churc1
uniprot id: Q66JD9
names: Function
names: Similarity
messages: Belongs to the Churchill family.
messages: Transcriptional activator that mediates FGF signaling during neural development (By similarity). Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself (By similarity).

8364:pgm1
gene id: 8364:pgm1
uniprot id: A0A6I8QZK6
uniprot id: Q6NVJ0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

8364:dusp7
gene id: 8364:dusp7
uniprot id: Q28EB3
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

8364:cs
gene id: 8364:cs
uniprot id: Q28DK1
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the citrate synthase family.
messages: Citrate synthase is found in nearly all cells capable of oxidative metabolism.
messages: Homodimer.
messages: Mitochondrion matrix

8364:galc
gene id: 8364:galc
uniprot id: A0A6I8QBD8
uniprot id: Q0VA39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 59 family.
messages: Hydrolyzes the galactose ester bonds of glycolipids such as galactosylceramide and galactosylsphingosine.
messages: Lysosome

8364:amhr2
gene id: 8364:amhr2
uniprot id: A0A8J1J5B4
uniprot id: A0A8J1J8R3
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

8364:LOC101733947
gene id: 8364:LOC101733947
uniprot id: A0A8J0SA96
uniprot id: A0A8J0SAA0
uniprot id: A0A8J0SAA3
uniprot id: A0A8J0SGL4
uniprot id: A0A8J0SGL9
uniprot id: A0A8J0SGM4
uniprot id: A0A8J0SI90
uniprot id: A0A8J0SI95
uniprot id: A0A8J0SIA1
uniprot id: A0A8J0SJH7
uniprot id: A0A8J0SJI6
uniprot id: A0A8J0SJJ0
uniprot id: A0A8J0SJJ3
uniprot id: A0A8J0SJJ8
uniprot id: A0A8J0T1U3
uniprot id: A0A8J1J9R8
uniprot id: A0A8J1J9S1
uniprot id: A0A8J1J9S2
uniprot id: A0A8J1J9S3
uniprot id: A0A8J1J9S5
uniprot id: A0A8J1J9S6
uniprot id: A0A8J1J9S8
uniprot id: A0A8J1J9T0
uniprot id: A0A8J1J9T1
uniprot id: A0A8J1J9T2
uniprot id: A0A8J1J9T5
uniprot id: A0A8J1J9T6
uniprot id: A0A8J1J9T7
uniprot id: A0A8J1J9U0
uniprot id: A0A8J1J9U1
uniprot id: A0A8J1J9U2
uniprot id: A0A8J1J9U5
uniprot id: A0A8J1JC85
uniprot id: A0A8J1JC90
uniprot id: A0A8J1JC95
uniprot id: A0A8J1JCA0
uniprot id: A0A8J1JCA5
uniprot id: A0A8J1JDB1
uniprot id: A0A8J1JDB5
uniprot id: A0A8J1JDC0
uniprot id: A0A8J1JDC5
uniprot id: A0A8J1JDC9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

8364:slc35f2
gene id: 8364:slc35f2
uniprot id: B0BMD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

8364:chst3
gene id: 8364:chst3
uniprot id: A0A803J4U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

8364:LOC116408582
gene id: 8364:LOC116408582
uniprot id: A0A8J1J5X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:dbx2
gene id: 8364:dbx2
uniprot id: A0A6I8PQS6
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100487139
gene id: 8364:LOC100487139
uniprot id: A0A1B8XZW2
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:minpp1
gene id: 8364:minpp1
uniprot id: A0A7D9N0D2
names: Similarity
messages: Belongs to the histidine acid phosphatase family. MINPP1 subfamily.

8364:LOC101732877
gene id: 8364:LOC101732877
uniprot id: A0A8J0R882
names: Subcellular Location Annotation
messages: Membrane

8364:pdp2
gene id: 8364:pdp2
uniprot id: A0A8J0QXV9
names: Similarity
messages: Belongs to the PP2C family.

8364:thibz
gene id: 8364:thibz
uniprot id: F6V0W1
names: Similarity
messages: Belongs to the bZIP family. NFIL3 subfamily.

8364:ap1b1
gene id: 8364:ap1b1
uniprot id: B2GUA2
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

8364:gsk3a
gene id: 8364:gsk3a
uniprot id: A0A8J0QRB7
uniprot id: A0A8J0R3E3
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

8364:LOC100489792
gene id: 8364:LOC100489792
uniprot id: F6RVG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

8364:rmdn2
gene id: 8364:rmdn2
uniprot id: Q0P4W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RMDN family.
messages: Membrane

8364:lrp4
gene id: 8364:lrp4
uniprot id: A0A8J1JFD7
names: Caution
names: Similarity
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:aoc2
gene id: 8364:aoc2
uniprot id: A0A8J1J164
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

8364:rnf43
gene id: 8364:rnf43
uniprot id: P0DPR2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZNRF3 family.
messages: Cell membrane
messages: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway (By similarity). Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification (PubMed:29769720).
messages: Endoplasmic reticulum membrane
messages: Nucleus envelope
messages: Simultaneous knockdown of RNF43 and ZNRF3 results in ectopic limb development.

8364:gdpd3
gene id: 8364:gdpd3
uniprot id: A4IGW3
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

8364:LOC116407777
gene id: 8364:LOC116407777
uniprot id: A0A8J1IY17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:eml4
gene id: 8364:eml4
uniprot id: A0A6I8PZT1
uniprot id: A0A6I8R977
uniprot id: A0A6I8SC30
uniprot id: A0A8J1JI25
uniprot id: Q6DIP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat EMAP family.
messages: Cytoplasm
messages: Essential for the formation and stability of microtubules (MTs) (By similarity). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (By similarity). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (By similarity).
messages: Homotrimer; self-association is mediated by the N-terminal coiled coil.
messages: Midbody
messages: cytoskeleton
messages: microtubule organizing center
messages: spindle

8364:rbl1
gene id: 8364:rbl1
uniprot id: A0A6I8RJ97
uniprot id: B4F726
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

8364:ctdp1
gene id: 8364:ctdp1
uniprot id: A0A8J0PJE6
uniprot id: A0A8J0SGD3
uniprot id: Q28F82
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: This promotes the activity of RNA polymerase II.

8364:pfdn1
gene id: 8364:pfdn1
uniprot id: A0A8J0QNX8
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

8364:tm2d1
gene id: 8364:tm2d1
uniprot id: A0A6I8QKF8
names: Subcellular Location Annotation
messages: Membrane

8364:atp13a-like
gene id: 8364:atp13a-like
uniprot id: A0A803JJD9
uniprot id: A0A803JZW7
uniprot id: A0A803K049
uniprot id: A0A8J0QZA4
uniprot id: A0A8J0SEL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

8364:adh1
gene id: 8364:adh1
uniprot id: A0A8J1JBB4
uniprot id: Q5M7K9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

8364:hrh4.g2
gene id: 8364:hrh4.g2
uniprot id: A0A8J1JRD6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:f7
gene id: 8364:f7
uniprot id: Q0V9B6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:fam53a
gene id: 8364:fam53a
uniprot id: Q66IH4
names: Similarity
messages: Belongs to the FAM53 family.

8364:fras1
gene id: 8364:fras1
uniprot id: A0A6I8QBY6
uniprot id: A0A6I8QTE1
names: Similarity
messages: Belongs to the FRAS1 family.

8364:slc45a3
gene id: 8364:slc45a3
uniprot id: F6ZBS1
names: Subcellular Location Annotation
messages: Membrane

8364:sntb1
gene id: 8364:sntb1
uniprot id: F7A289
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

8364:lyrm9
gene id: 8364:lyrm9
uniprot id: A0A8J1J178
uniprot id: B4F6X2
names: Similarity
messages: Belongs to the complex I LYR family. LYRM9 subfamily.

8364:LOC100485112
gene id: 8364:LOC100485112
uniprot id: A0A8J0QJM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100485069
gene id: 8364:LOC100485069
uniprot id: A0A8J1ISA6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC116408616
gene id: 8364:LOC116408616
uniprot id: A0A8J1J2P0
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100490939
gene id: 8364:LOC100490939
uniprot id: A0A6I8QCI3
uniprot id: A0A8J0QMW4
uniprot id: A0A8J1JEZ5
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:or52k1
gene id: 8364:or52k1
uniprot id: A0A8J0QW35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:zfhx4
gene id: 8364:zfhx4
uniprot id: A0A6I8RA16
uniprot id: A0A8J0SGX2
names: Subcellular Location Annotation
messages: Nucleus

8364:st6galnac2
gene id: 8364:st6galnac2
uniprot id: A0A6I8Q1E2
uniprot id: A0A8J1IWA6
uniprot id: A4IIC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8364:larp7
gene id: 8364:larp7
uniprot id: A0A8J1JKM3
uniprot id: Q28G87
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LARP7 family.
messages: Core component of the 7SK RNP complex. Associates with box C/D small nucleolar ribonucleoprotein (snoRNP) complexes.
messages: RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function. Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II. The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (By similarity). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex. LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing. Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes. U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (By similarity).
messages: The xRRM domain binds the 3' end of 7SK snRNA (7SK RNA) at the top of stem-loop 4.
messages: nucleoplasm

8364:slc24a5
gene id: 8364:slc24a5
uniprot id: A0A6I8SU97
uniprot id: F7A625
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

8364:LOC100496061
gene id: 8364:LOC100496061
uniprot id: F6UXP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

8364:pmm2
gene id: 8364:pmm2
uniprot id: B5DEB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

8364:ddx47
gene id: 8364:ddx47
uniprot id: F7DX11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.
messages: Cytoplasm
messages: Nucleus

8364:adra1b
gene id: 8364:adra1b
uniprot id: A0A803JBF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
messages: caveola

8364:uts2
gene id: 8364:uts2
uniprot id: A0A803JKK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

8364:nudt6
gene id: 8364:nudt6
uniprot id: A0A8J0SDT6
uniprot id: A0A8J0T5A0
uniprot id: F6WT30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Cytoplasm
messages: May contribute to the regulation of cell proliferation.
messages: Mitochondrion
messages: Monomer and homodimer.
messages: Nucleus

8364:gad2
gene id: 8364:gad2
uniprot id: F6UUY1
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

8364:gtf2f1
gene id: 8364:gtf2f1
uniprot id: A0A8J0S5T3
uniprot id: B1H3B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF alpha subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.

8364:LOC100494804
gene id: 8364:LOC100494804
uniprot id: A0A6I8QGS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the catalase family.
messages: Peroxisome

8364:satb2
gene id: 8364:satb2
uniprot id: A0A6I8RC36
uniprot id: A0A6I8RFA7
uniprot id: A0A8J0QQU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

8364:grid2
gene id: 8364:grid2
uniprot id: A0A803J7I0
uniprot id: A0A8J1JMC6
uniprot id: A0A8J1JPS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8364:LOC116409681
gene id: 8364:LOC116409681
uniprot id: A0A8J1J973
names: Similarity
messages: Belongs to the aldo/keto reductase family.

8364:gjd2
gene id: 8364:gjd2
uniprot id: A0A803JSX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8364:itga2b.1
gene id: 8364:itga2b.1
uniprot id: A0A6I8Q5U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

8364:pclaf
gene id: 8364:pclaf
uniprot id: Q6AZL2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with pcna.
messages: Nucleus
messages: PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with pcna is disrupted, facilitating the interaction between monoubiquitinated pcna and the translesion DNA synthesis DNA polymerase eta (polh) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number (By similarity).
messages: perinuclear region

8364:LOC100491113
gene id: 8364:LOC100491113
uniprot id: F7BKS1
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

8364:stradb
gene id: 8364:stradb
uniprot id: F7A5J0
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

8364:clns1a
gene id: 8364:clns1a
uniprot id: A0A8J1J1P8
uniprot id: Q28H03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pICln (TC 1.A.47) family.
messages: Nucleus

8364:LOC100494922
gene id: 8364:LOC100494922
uniprot id: F7CP55
names: Similarity
messages: Belongs to the peptidase C2 family.

8364:crtc2
gene id: 8364:crtc2
uniprot id: A0A803JH97
uniprot id: A0A803K6X7
uniprot id: A0A8J1IM93
uniprot id: A0A8J1IQ64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TORC family.
messages: Cytoplasm
messages: Nucleus

8364:med18
gene id: 8364:med18
uniprot id: B0JYV7
uniprot id: Q28GE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8364:irf6
gene id: 8364:irf6
uniprot id: Q28ET3
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100487104
gene id: 8364:LOC100487104
uniprot id: A0A8J0QXQ2
uniprot id: A0A8J0R1Y8
uniprot id: A0A8J1JCH6
names: Similarity
messages: Belongs to the SLBP family.

8364:cavin4
gene id: 8364:cavin4
uniprot id: A0A8J0QMP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

8364:samd4b
gene id: 8364:samd4b
uniprot id: A0A6I8SXW1
uniprot id: A0A8J0SM26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAUG family.
messages: Cytoplasm

8364:cyp8b1.1
gene id: 8364:cyp8b1.1
uniprot id: A0A803JLB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

8364:gbp5
gene id: 8364:gbp5
uniprot id: A0A8J0QC78
uniprot id: A0A8J0SHY7
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8364:dimt1
gene id: 8364:dimt1
uniprot id: B1H127
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

8364:tmem43
gene id: 8364:tmem43
uniprot id: A0A6I8RBW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM43 family.
messages: Membrane

8364:cmtm7
gene id: 8364:cmtm7
uniprot id: F7AZ09
names: Subcellular Location Annotation
messages: Membrane

8364:ptpn22
gene id: 8364:ptpn22
uniprot id: A0A8J0T194
uniprot id: A0A8J1J6M2
uniprot id: A0A8J1J7P0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.

8364:nudt7
gene id: 8364:nudt7
uniprot id: F6V6C1
names: Similarity
messages: Belongs to the Nudix hydrolase family. PCD1 subfamily.

8364:slc2a2
gene id: 8364:slc2a2
uniprot id: Q5I0A1
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

8364:adamts10
gene id: 8364:adamts10
uniprot id: A0A6I8QWM6
uniprot id: A0A8J1JSI2
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:zdhhc22
gene id: 8364:zdhhc22
uniprot id: A0A6I8PMK3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8364:acrbp.1
gene id: 8364:acrbp.1
uniprot id: A0A8J1JVV2
names: Subcellular Location Annotation
messages: acrosome

8364:LOC100496122
gene id: 8364:LOC100496122
uniprot id: A0A8J0QQC8
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:rtn2
gene id: 8364:rtn2
uniprot id: Q4FZ58
names: Function
names: Sequence Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Contaminating sequence. Sequence of unknown origin in the C-terminal part.
messages: Endoplasmic reticulum membrane
messages: Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity (By similarity). Enhances trafficking of the glutamate transporter SLC1A1/EAAC1 from the endoplasmic reticulum to the cell surface (By similarity). Plays a role in the translocation of SLC2A4/GLUT4 from intracellular membranes to the cell membrane which facilitates the uptake of glucose into the cell (By similarity).
messages: Sarcoplasmic reticulum membrane
messages: T-tubule
messages: Z line
messages: cytoskeleton
messages: sarcolemma

8364:rarres1
gene id: 8364:rarres1
uniprot id: B2GUA9
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

8364:LOC116406837
gene id: 8364:LOC116406837
uniprot id: A0A8J1IT49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:t2r46
gene id: 8364:t2r46
uniprot id: Q2AB41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:ldlrad3
gene id: 8364:ldlrad3
uniprot id: A4IHY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDLR family.
messages: Cell membrane

8364:lpin1
gene id: 8364:lpin1
uniprot id: A0A6I8Q4W7
uniprot id: A0A6I8R3A9
uniprot id: A0A6I8SZX3
uniprot id: A0A8J0SEG1
uniprot id: F6WFG7
uniprot id: Q0P4S3
names: Similarity
messages: Belongs to the lipin family.

8364:ust
gene id: 8364:ust
uniprot id: A0A6I8SUF9
uniprot id: A0A8J0T3K3
uniprot id: A0A8J1JJD6
uniprot id: A0A8J1JJE0
uniprot id: A0A8J1JLT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:adamts8
gene id: 8364:adamts8
uniprot id: A0A8J0QSE7
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:LOC101730599
gene id: 8364:LOC101730599
uniprot id: A0A6I8Q5X0
uniprot id: A0A8J0T1Z8
names: Subcellular Location Annotation
messages: Membrane

8364:LOC116409593
gene id: 8364:LOC116409593
uniprot id: A0A8J1J8I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:gpr158
gene id: 8364:gpr158
uniprot id: F6U1J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:zbtb8os
gene id: 8364:zbtb8os
uniprot id: A0A8J0PIH9
uniprot id: A0A8J0S7P8
names: Similarity
names: Subunit
messages: Belongs to the archease family.
messages: Component of the tRNA-splicing ligase complex.

8364:LOC116412245
gene id: 8364:LOC116412245
uniprot id: A0A8J1JVG6
names: Similarity
messages: Belongs to the Izumo family.

8364:qrfprl2.2
gene id: 8364:qrfprl2.2
uniprot id: A0A6I8SPC0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:LOC101735142
gene id: 8364:LOC101735142
uniprot id: A0A8J0T686
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:otud6b
gene id: 8364:otud6b
uniprot id: Q5M8L0
names: Function
messages: Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of different cellular processes.

8364:stmn1
gene id: 8364:stmn1
uniprot id: Q66KA8
names: Similarity
messages: Belongs to the stathmin family.

8364:LOC100493138
gene id: 8364:LOC100493138
uniprot id: A0A1B8Y900
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

8364:tnn
gene id: 8364:tnn
uniprot id: F6Y6E2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:igfbp1
gene id: 8364:igfbp1
uniprot id: Q499C6
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds equally well IGF1 and IGF2.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:hpcal1
gene id: 8364:hpcal1
uniprot id: Q28IM6
names: Miscellaneous
names: Similarity
messages: Belongs to the recoverin family.
messages: Probably binds two or three calcium ions.

8364:perp
gene id: 8364:perp
uniprot id: A0A803JM69
uniprot id: A4IHS5
uniprot id: B7ZTK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

8364:mogs
gene id: 8364:mogs
uniprot id: F6U900
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
messages: Endoplasmic reticulum membrane

8364:gadd45b
gene id: 8364:gadd45b
uniprot id: F6VB60
names: Similarity
messages: Belongs to the GADD45 family.

8364:LOC101734231
gene id: 8364:LOC101734231
uniprot id: A0A6I8QN31
names: Similarity
messages: Belongs to the TGF-beta family.

8364:bmpr2
gene id: 8364:bmpr2
uniprot id: A0A6I8R3J8
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

8364:ccnt2
gene id: 8364:ccnt2
uniprot id: A0A6I8SSL8
uniprot id: A0A8J0QY45
uniprot id: A0A8J0R6G4
names: Similarity
messages: Belongs to the cyclin family.

8364:gga3
gene id: 8364:gga3
uniprot id: B3DM76
uniprot id: F6VA85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

8364:dtl
gene id: 8364:dtl
uniprot id: Q6P1W0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat cdt2 family.
messages: Chromosome
messages: Component of the DCX(DTL) E3 ubiquitin ligase complex, at least composed of cul4 (cul4a or cul4b), ddb1, dtl/cdt2 and rbx1.
messages: Nucleus
messages: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:16949367). May play a role in the regulation of the circadian clock (By similarity).
messages: centrosome

8364:trpm8b
gene id: 8364:trpm8b
uniprot id: A0A6I8PW05
uniprot id: A0A6I8QL26
uniprot id: A0A8J1IS36
uniprot id: C5IJY9
uniprot id: F6TBS4
names: Subcellular Location Annotation
messages: Membrane

8364:LOC105948110
gene id: 8364:LOC105948110
uniprot id: A0A8J1IS81
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:pcid2
gene id: 8364:pcid2
uniprot id: Q28I40
names: Similarity
messages: Belongs to the CSN12 family.

8364:LOC100490872
gene id: 8364:LOC100490872
uniprot id: A0A8J0QL59
names: Similarity
messages: Belongs to the polyadenylate-binding protein type-1 family.

8364:unc45b
gene id: 8364:unc45b
uniprot id: D7REX8
names: Function
names: Sequence Caution
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A band
messages: Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain (By similarity). Plays a role in sarcomere formation during muscle cell development. Is necessary for normal early lens development.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Detected initially throughout the somites and the heart and gradually also expressed in the jaw, branchial arches and body wall muscles at later embryonic stages.
messages: Z line
messages: cytosol
messages: perinuclear region

8364:gon4l
gene id: 8364:gon4l
uniprot id: A0A8J1INX8
uniprot id: A0A8J1INY1
uniprot id: A0A8J1INY2
uniprot id: A0A8J1IRC6
uniprot id: A0A8J1IRD1
uniprot id: F6SYN8
uniprot id: F6SYP6
names: Subcellular Location Annotation
messages: Nucleus

8364:mfhas1
gene id: 8364:mfhas1
uniprot id: A4IIK1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Probable GTP-binding protein. Functions in innate immunity and more specifically the inflammatory response as a regulator of the Toll-like receptor TLR2 and TLR4 signaling pathways.

8364:fam20a.2
gene id: 8364:fam20a.2
uniprot id: A0A8J1IX95
names: Similarity
messages: Belongs to the FAM20 family.

8364:dtna
gene id: 8364:dtna
uniprot id: A0A6I8RQS7
uniprot id: A0A8J0SGL7
uniprot id: A0A8J0SNJ9
uniprot id: A0A8J0SNK4
uniprot id: A0A8J0SQ49
uniprot id: A0A8J0SR71
uniprot id: A0A8J0SRE3
uniprot id: A0A8J1JN37
uniprot id: A0A8J1JN43
uniprot id: A0A8J1JN45
uniprot id: A0A8J1JN48
uniprot id: A0A8J1JN51
uniprot id: A0A8J1JN53
uniprot id: A0A8J1JQJ4
uniprot id: A0A8J1JQK0
uniprot id: A0A8J1JQK6
uniprot id: A0A8J1JRV3
uniprot id: Q0V9N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

8364:g6pd
gene id: 8364:g6pd
uniprot id: A0A6I8SJ67
uniprot id: Q28DI9
uniprot id: Q5BKM9
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.

8364:LOC100485294
gene id: 8364:LOC100485294
uniprot id: A0A6I8QAK0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:LOC116406931
gene id: 8364:LOC116406931
uniprot id: A0A6I8PLK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:mtmr4
gene id: 8364:mtmr4
uniprot id: A0A6I8SJI0
uniprot id: A0A7D9NMD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

8364:LOC100216027
gene id: 8364:LOC100216027
uniprot id: A0A803K9V7
uniprot id: B4F6H9
names: Similarity
messages: Belongs to the aldo/keto reductase family.

8364:mymk
gene id: 8364:mymk
uniprot id: A0A803J6Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

8364:mmp24
gene id: 8364:mmp24
uniprot id: A0A6I8QJJ2
uniprot id: A0A8J1IXU9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

8364:ptprf
gene id: 8364:ptprf
uniprot id: A0A6I8RQF6
uniprot id: A0A6I8SGH6
uniprot id: A0A8J0QYV0
uniprot id: A0A8J0R325
uniprot id: A0A8J1JFY3
uniprot id: A0A8J1JFY4
uniprot id: A0A8J1JFY5
uniprot id: A0A8J1JFY8
uniprot id: A0A8J1JFY9
uniprot id: A0A8J1JFZ2
uniprot id: A0A8J1JFZ3
uniprot id: A0A8J1JFZ7
uniprot id: A0A8J1JID0
uniprot id: A0A8J1JID6
uniprot id: A0A8J1JJG2
uniprot id: A0A8J1JJG8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.

8364:grm4
gene id: 8364:grm4
uniprot id: A0A8J1J4B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

8364:tff3.8
gene id: 8364:tff3.8
uniprot id: A0A803KDC0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:emc1
gene id: 8364:emc1
uniprot id: A0A803JF46
uniprot id: F6TUQ9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC1 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:maco1
gene id: 8364:maco1
uniprot id: Q2TLY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the macoilin family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus membrane
messages: Rough endoplasmic reticulum membrane

8364:ada
gene id: 8364:ada
uniprot id: F6RPM0
uniprot id: Q63ZU0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity).
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm
messages: Cytoplasmic vesicle lumen
messages: Lysosome

8364:LOC108648843
gene id: 8364:LOC108648843
uniprot id: A0A8J0SWV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:foxd3
gene id: 8364:foxd3
uniprot id: Q5M7L9
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional repressor that is an essential upstream regulator of neural crest determination. Also acts in a negative auto-regulator loop by inhibiting the transcription of its own gene (By similarity).

8364:tmed7
gene id: 8364:tmed7
uniprot id: Q6P2V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

8364:myoc
gene id: 8364:myoc
uniprot id: A0A6I8QYV5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:nfrkb
gene id: 8364:nfrkb
uniprot id: A0A6I8PSP8
uniprot id: Q6P4L9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NFRKB family.
messages: Binds to DNA.
messages: Nucleus

8364:speg
gene id: 8364:speg
uniprot id: A0A6I8Q2Q1
uniprot id: A0A8J1ISX6
uniprot id: A0A8J1ISX9
uniprot id: A0A8J1ISY5
uniprot id: A0A8J1IVB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cell membrane

8364:LOC116412151
gene id: 8364:LOC116412151
uniprot id: A0A8J1JX78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8364:crygdl.13
gene id: 8364:crygdl.13
uniprot id: A0A8J0QQC2
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:dlg5
gene id: 8364:dlg5
uniprot id: A0A6I8QNJ0
uniprot id: A0A8J0QT32
uniprot id: A0A8J1JV89
names: Subcellular Location Annotation
messages: Cytoplasm

8364:syn2
gene id: 8364:syn2
uniprot id: A0A6I8S8F0
names: Similarity
messages: Belongs to the synapsin family.

8364:ptger1
gene id: 8364:ptger1
uniprot id: A0A803JAL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC101731903
gene id: 8364:LOC101731903
uniprot id: A0A6I8S2J6
names: Similarity
messages: Belongs to the HARBI1 family.

8364:pop7
gene id: 8364:pop7
uniprot id: A4IGJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone-like Alba family.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
messages: nucleolus

8364:otogl2
gene id: 8364:otogl2
uniprot id: A0A6I8RWS0
uniprot id: A0A803JWL6
uniprot id: A0A803K095
uniprot id: A0A8J1JU18
uniprot id: A0A8J1JU19
uniprot id: A0A8J1JU20
uniprot id: A0A8J1JU26
uniprot id: A0A8J1JU30
uniprot id: A0A8J1JU31
uniprot id: A0A8J1JU35
uniprot id: A0A8J1JU37
uniprot id: A0A8J1JU40
uniprot id: A0A8J1JU43
uniprot id: A0A8J1JU49
uniprot id: A0A8J1JWI1
uniprot id: A0A8J1JWI6
uniprot id: A0A8J1JWJ8
uniprot id: A0A8J1JWK4
uniprot id: A0A8J1JXV1
uniprot id: A0A8J1JXW6
uniprot id: A0A8J1JXX2
uniprot id: A0A8J1JXX8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:epc2
gene id: 8364:epc2
uniprot id: Q6DJR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: May play a role in transcription or DNA repair.
messages: Nucleus

8364:amer2
gene id: 8364:amer2
uniprot id: A4IGN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Amer family.
messages: Cell membrane
messages: Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex (By similarity).

8364:qki
gene id: 8364:qki
uniprot id: A0A8J0SDD3
uniprot id: A0A8J0SKC7
uniprot id: A0A8J0SLR0
uniprot id: A0A8J0SN07
uniprot id: A0A8J0SN43
uniprot id: A0A8J0SN48
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:LOC105948499
gene id: 8364:LOC105948499
uniprot id: A0A7D9NKN6
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8364:LOC100487756
gene id: 8364:LOC100487756
uniprot id: A0A1B8XZW2
uniprot id: Q28D37
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by rag1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:mcur1
gene id: 8364:mcur1
uniprot id: A0A8J0T1J6
uniprot id: Q0P4J6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC90 family.
messages: Key regulator of mitochondrial calcium uniporter (mcu) required for calcium entry into mitochondrion.
messages: Mitochondrion inner membrane

8364:s100pbp
gene id: 8364:s100pbp
uniprot id: A0A6I8PV28
uniprot id: A8KBC1
uniprot id: Q28DZ0
names: Subcellular Location Annotation
messages: Nucleus

8364:jph4
gene id: 8364:jph4
uniprot id: A0A8J0QT57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:crygdl.1
gene id: 8364:crygdl.1
uniprot id: A0A6I8R5C2
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:commd6
gene id: 8364:commd6
uniprot id: Q28HC7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Inhibits TNF-induced nfkb1 activation.
messages: Nucleus

8364:gldn
gene id: 8364:gldn
uniprot id: F7E6V8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:mrpl37
gene id: 8364:mrpl37
uniprot id: F6R7P1
names: Subcellular Location Annotation
messages: Mitochondrion

8364:tars3
gene id: 8364:tars3
uniprot id: Q0V9S0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage.
messages: Cytoplasm
messages: Nucleus

8364:amy2a
gene id: 8364:amy2a
uniprot id: F6QEY0
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

8364:mcm4
gene id: 8364:mcm4
uniprot id: Q6GL41
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the mcm2-7 complex (RLF-M). The complex forms a toroidal hexameric ring with the proposed subunit order mcm2-mcm6-mcm4-mcm7-mcm3-mcm5. The heterodimer of mmcm3/mcm5 interacts with mcm4, mmcm6, mcm7 and weakly with mcm2. Component of the CMG helicase complex, composed of the mcm2-7 complex, the GINS complex and cdc45.
messages: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.
messages: Hyperphosphorylated during mitosis in a mechanism requiring cdc2-cyclin B and other kinases. Undergoes dephosphorylation after exiting mitosis, existing in a partially phosphorylated state in the cytosolic interphase mcm complex which associates with the pre-replication complexes (pre-Rcs). Complete dephosphorylation inactivates the mcm complex, preventing its binding to chromatin. Becomes actively phosphorylated during S phase once the mcm complex is assembled on the chromatin. This chromatin-associated phosphorylation occurs during the activation of the pre-Rcs and is independent of cdks. Phosphorylated by the cdc7-dbf4b complex (By similarity).
messages: Nucleus

8364:tat
gene id: 8364:tat
uniprot id: Q6DID9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.

8364:gab1
gene id: 8364:gab1
uniprot id: A0A7D9NL28
uniprot id: A0A8J1J2W5
names: Similarity
messages: Belongs to the GAB family.

8364:LOC100490615
gene id: 8364:LOC100490615
uniprot id: A0A8J0QVV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

8364:ttc19
gene id: 8364:ttc19
uniprot id: A0A8J0T0F4
uniprot id: F6R444
names: Similarity
messages: Belongs to the TTC19 family.

8364:slc30a2
gene id: 8364:slc30a2
uniprot id: F7CI99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

8364:LOC108648247
gene id: 8364:LOC108648247
uniprot id: A0A8J0T5A5
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:acp7
gene id: 8364:acp7
uniprot id: A0A803J5Q9
uniprot id: A0A8J0QG96
uniprot id: A0A8J1IL21
uniprot id: A0A8J1IN08
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

8364:LOC105948387
gene id: 8364:LOC105948387
uniprot id: A0A8J1IYQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8364:nefh
gene id: 8364:nefh
uniprot id: A0A6I8QND8
names: Similarity
messages: Belongs to the intermediate filament family.

8364:LOC116408818
gene id: 8364:LOC116408818
uniprot id: A0A8J1J6K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parathyroid hormone family.
messages: Secreted

8364:tlr8
gene id: 8364:tlr8
uniprot id: A0A6I8PUG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

8364:rab11fip3
gene id: 8364:rab11fip3
uniprot id: A0A803JAL8
uniprot id: A0A8J0SVT8
uniprot id: A0A8J1IST9
uniprot id: A0A8J1ISU6
uniprot id: A0A8J1IV89
names: Subcellular Location Annotation
messages: Cleavage furrow
messages: Endosome membrane
messages: Membrane
messages: Midbody
messages: Recycling endosome membrane

8364:LOC116409637
gene id: 8364:LOC116409637
uniprot id: A0A8J1JB24
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:gtf2h4
gene id: 8364:gtf2h4
uniprot id: Q5FV97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

8364:myadml2
gene id: 8364:myadml2
uniprot id: F7D3L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL family.
messages: Membrane

8364:trhde
gene id: 8364:trhde
uniprot id: A0A6I8PX97
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

8364:lcor
gene id: 8364:lcor
uniprot id: A0A8J1JRU5
names: Subcellular Location Annotation
messages: Nucleus

8364:insr
gene id: 8364:insr
uniprot id: A0A6I8RXV0
uniprot id: A0A8J0SBW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

8364:gatad1
gene id: 8364:gatad1
uniprot id: B1H2T9
names: Subcellular Location Annotation
messages: Nucleus

8364:faxc
gene id: 8364:faxc
uniprot id: A0A5S6JZR7
names: Similarity
messages: Belongs to the FAX family.

8364:bet1l
gene id: 8364:bet1l
uniprot id: A0A8J0R326
uniprot id: F6VLD5
names: Subcellular Location Annotation
messages: Membrane

8364:pfkp
gene id: 8364:pfkp
uniprot id: A0A6I8Q4K8
uniprot id: A0A6I8SKY0
uniprot id: A0A8J0SFS1
uniprot id: A0A8J0SPB2
uniprot id: A0A8J0SQE5
uniprot id: A0A8J0SQF0
uniprot id: Q6P4Y8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:pcolce2
gene id: 8364:pcolce2
uniprot id: Q6DJ32
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:cyp11a1
gene id: 8364:cyp11a1
uniprot id: F6W7I0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
messages: Belongs to the cytochrome P450 family.
messages: Mitochondrion inner membrane

8364:slc18a3
gene id: 8364:slc18a3
uniprot id: Q0IHP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Vesicular transporter family.
messages: Membrane

8364:LOC116409642
gene id: 8364:LOC116409642
uniprot id: A0A8J1JB31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:scrn2
gene id: 8364:scrn2
uniprot id: A0A8J0S9H4
uniprot id: F6QJA0
uniprot id: Q0V984
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

8364:nup88
gene id: 8364:nup88
uniprot id: F7C806
names: Subcellular Location Annotation
messages: nuclear pore complex

8364:trmo
gene id: 8364:trmo
uniprot id: A0A8J0T258
uniprot id: B0BLU9
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

8364:LOC100498223
gene id: 8364:LOC100498223
uniprot id: A0A8J1JFH6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:ints11
gene id: 8364:ints11
uniprot id: A0A6I8PNB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
messages: Nucleus

8364:htr4
gene id: 8364:htr4
uniprot id: A0A803J9I2
uniprot id: A0A803JX13
uniprot id: A0A8J1JCF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Endosome
messages: Membrane
messages: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

8364:tspan4
gene id: 8364:tspan4
uniprot id: A0A6I8SSV2
uniprot id: B7ZSN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8364:dlst
gene id: 8364:dlst
uniprot id: Q6DIZ2
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

8364:cldn19
gene id: 8364:cldn19
uniprot id: A0A6I8S3H8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8364:atp6v1b1
gene id: 8364:atp6v1b1
uniprot id: B0BMI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

8364:ptpn13
gene id: 8364:ptpn13
uniprot id: A0A6I8QDQ3
uniprot id: A0A6I8RFM9
uniprot id: A0A8J0S6G7
uniprot id: A0A8J0SAV3
uniprot id: A0A8J0SCP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: Regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.
messages: cytoskeleton

8364:f3
gene id: 8364:f3
uniprot id: A0A6I8PS78
uniprot id: A0A8J0QNV1
uniprot id: A0A8J1JG62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.

8364:pik3cb
gene id: 8364:pik3cb
uniprot id: Q0IHS8
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

8364:pard6b
gene id: 8364:pard6b
uniprot id: B3DM40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

8364:slc39a10
gene id: 8364:slc39a10
uniprot id: A0A6I8RFG7
names: Subcellular Location Annotation
messages: Membrane

8364:ifih1
gene id: 8364:ifih1
uniprot id: A0A8J0QN73
uniprot id: A0A8J1IU69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

8364:LOC100497171
gene id: 8364:LOC100497171
uniprot id: A0A6I8PT87
names: Similarity
messages: Belongs to the LCA5 family.

8364:krt8.2
gene id: 8364:krt8.2
uniprot id: A0A8J0PII1
uniprot id: A0A8J1IVM7
uniprot id: Q28D97
names: Similarity
messages: Belongs to the intermediate filament family.

8364:cacng5
gene id: 8364:cacng5
uniprot id: A0A803JF33
names: Similarity
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

8364:ndrg1
gene id: 8364:ndrg1
uniprot id: A0A6I8QEF7
uniprot id: Q66IG4
names: Function
names: Similarity
messages: Belongs to the NDRG family.
messages: May be involved in pronephros development, after specification of the pronephros.

8364:ska2
gene id: 8364:ska2
uniprot id: A0A6I8SUY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA2 family.
messages: spindle

8364:LOC101734114
gene id: 8364:LOC101734114
uniprot id: A0A8J0R1C7
names: Subcellular Location Annotation
messages: Membrane

8364:wnt10b
gene id: 8364:wnt10b
uniprot id: A0A8J0SG89
uniprot id: A0JMB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8364:hoxc6
gene id: 8364:hoxc6
uniprot id: A0A803J8M7
uniprot id: A0A8J0QYS1
names: Subcellular Location Annotation
messages: Nucleus

8364:zer1
gene id: 8364:zer1
uniprot id: A0A8J0SSH2
names: Similarity
messages: Belongs to the zyg-11 family.

8364:htr3b
gene id: 8364:htr3b
uniprot id: A0A6I8PKU9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC100489122
gene id: 8364:LOC100489122
uniprot id: F7D3H1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:ckap5
gene id: 8364:ckap5
uniprot id: A0A6I8RYM9
uniprot id: A0A6I8SKI3
uniprot id: A0A8J0SJV8
uniprot id: A0A8J0SL95
uniprot id: F6XPW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOG/XMAP215 family.
messages: kinetochore

8364:idh3a
gene id: 8364:idh3a
uniprot id: Q6P314
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

8364:slain1
gene id: 8364:slain1
uniprot id: A0A803JJF4
uniprot id: A0A8J0S703
uniprot id: A0A8J0SEI7
uniprot id: A8E4V2
uniprot id: F6RQ94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLAIN motif-containing family.
messages: Microtubule plus-end tracking protein that might be involved in the regulation of cytoplasmic microtubule dynamics, microtubule organization and microtubule elongation.
messages: cytoskeleton

8364:tubd1
gene id: 8364:tubd1
uniprot id: Q6DIM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a positive regulator of hedgehog signaling and regulates ciliary function.
messages: Belongs to the tubulin family.
messages: Cytoplasm
messages: Nucleus
messages: centriole
messages: cilium

8364:LOC108647426
gene id: 8364:LOC108647426
uniprot id: A0A8J1ITB8
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:LOC116412005
gene id: 8364:LOC116412005
uniprot id: A0A8J1JSJ6
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:LOC108648286
gene id: 8364:LOC108648286
uniprot id: A0A8J1IT55
names: Subcellular Location Annotation
messages: Membrane

8364:tnks2
gene id: 8364:tnks2
uniprot id: B0JZC7
names: Similarity
messages: Belongs to the ARTD/PARP family.

8364:LOC100487746
gene id: 8364:LOC100487746
uniprot id: A0A803KBZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8364:bcl9
gene id: 8364:bcl9
uniprot id: A0A6I8T1T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

8364:adgra1
gene id: 8364:adgra1
uniprot id: A0A8J0T5S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

8364:LOC116409580
gene id: 8364:LOC116409580
uniprot id: A0A8J1JBY8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:rps5
gene id: 8364:rps5
uniprot id: Q28EJ8
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

8364:slc7a10
gene id: 8364:slc7a10
uniprot id: F7C3N7
names: Subcellular Location Annotation
messages: Membrane

8364:pdgfa
gene id: 8364:pdgfa
uniprot id: A0A6I8Q0E4
uniprot id: A0A7D9NKY7
uniprot id: A0A8J0SMK9
uniprot id: A0A8J1IU51
uniprot id: A0A8J1IUY4
uniprot id: B0BM23
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

8364:LOC100486257
gene id: 8364:LOC100486257
uniprot id: A0A6I8PK15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:ca11
gene id: 8364:ca11
uniprot id: A0A6I8QRV1
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

8364:acot13
gene id: 8364:acot13
uniprot id: Q6DER5
names: Similarity
messages: Belongs to the thioesterase PaaI family.

8364:LOC116412172
gene id: 8364:LOC116412172
uniprot id: A0A8J1JYS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:tap1
gene id: 8364:tap1
uniprot id: A0A6I8RDH0
names: Subcellular Location Annotation
messages: Membrane

8364:folr1
gene id: 8364:folr1
uniprot id: A0A8J0SQV7
uniprot id: A0A8J0T0C1
uniprot id: A0A8J0T128
uniprot id: F7CGN2
uniprot id: Q6P638
names: Similarity
messages: Belongs to the folate receptor family.

8364:LOC100496324
gene id: 8364:LOC100496324
uniprot id: A0A8J0T5U4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:picalml
gene id: 8364:picalml
uniprot id: B2GU37
names: Similarity
messages: Belongs to the PICALM/SNAP91 family.

8364:aarsd1
gene id: 8364:aarsd1
uniprot id: A0A8J1IW80
uniprot id: B4F6M0
uniprot id: F6U4Q7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.

8364:serinc1.1
gene id: 8364:serinc1.1
uniprot id: A0A6I8RKU1
uniprot id: A0A803KGZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

8364:LOC100485335
gene id: 8364:LOC100485335
uniprot id: A0A6I8PLT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

8364:LOC116408911
gene id: 8364:LOC116408911
uniprot id: A0A803JJC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

8364:rnd3
gene id: 8364:rnd3
uniprot id: Q6DJ10
names: Function
messages: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

8364:ube2n
gene id: 8364:ube2n
uniprot id: Q6P349
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8364:hook2
gene id: 8364:hook2
uniprot id: F6VBN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

8364:cplane2
gene id: 8364:cplane2
uniprot id: A0A8J0PIT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.
messages: cilium basal body

8364:hoxc8
gene id: 8364:hoxc8
uniprot id: Q6DIE5
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC101731098
gene id: 8364:LOC101731098
uniprot id: A0A8J0R6D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:rps19
gene id: 8364:rps19
uniprot id: A0A8J0QVR1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS19 family.

8364:LOC100489744
gene id: 8364:LOC100489744
uniprot id: A0A6I8S609
names: Subcellular Location Annotation
messages: Membrane

8364:kat8
gene id: 8364:kat8
uniprot id: Q28CP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

8364:LOC101734061
gene id: 8364:LOC101734061
uniprot id: A0A1B8Y8R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:c11orf68
gene id: 8364:c11orf68
uniprot id: F7CH37
names: Similarity
messages: Belongs to the UPF0696 family.

8364:mrpl27
gene id: 8364:mrpl27
uniprot id: A4QNF8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

8364:hmgcll1
gene id: 8364:hmgcll1
uniprot id: A0A6I8PVX1
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

8364:LOC101734776
gene id: 8364:LOC101734776
uniprot id: A0A8J0R409
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:pkd1
gene id: 8364:pkd1
uniprot id: A0A6I8SPS6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:mcm10
gene id: 8364:mcm10
uniprot id: A0A8J0S9L0
uniprot id: Q28E45
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication (By similarity).
messages: Belongs to the MCM10 family.
messages: Each zinc finger-like domain binds a zinc ion and is involved in both ssDNA and dsDNA binding, as is the OB-fold domain.
messages: Nucleus
messages: Self-associates.
messages: The N-terminal domain mediates homodimerization.

8364:LOC116407782
gene id: 8364:LOC116407782
uniprot id: A0A803KC46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC116407582
gene id: 8364:LOC116407582
uniprot id: Q28D68
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:LOC100496635
gene id: 8364:LOC100496635
uniprot id: A0A6I8Q104
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

8364:narf
gene id: 8364:narf
uniprot id: F6WBE8
names: Similarity
messages: Belongs to the NARF family.

8364:nell1
gene id: 8364:nell1
uniprot id: A0A8J1JIS6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:capn9
gene id: 8364:capn9
uniprot id: B2GUG2
names: Similarity
messages: Belongs to the peptidase C2 family.

8364:LOC101731703
gene id: 8364:LOC101731703
uniprot id: A0A8J1JK38
names: Similarity
messages: Belongs to the PACS family.

8364:LOC116407804
gene id: 8364:LOC116407804
uniprot id: A0A8J1IVR8
names: Subcellular Location Annotation
messages: Membrane

8364:qpctl
gene id: 8364:qpctl
uniprot id: A0A6I8QDP8
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

8364:ccng1
gene id: 8364:ccng1
uniprot id: Q6DIY1
names: Similarity
messages: Belongs to the cyclin family.

8364:slc51a-like.1
gene id: 8364:slc51a-like.1
uniprot id: A0A8J1J0Y7
uniprot id: A0A8J1J0Z6
uniprot id: A0A8J1J0Z7
uniprot id: A9ULC7
uniprot id: B7ZTY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST-alpha family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for the translocation of bile acids (such as taurocholate), steroids (such as estrone sulfate), and eicosanoids (such as prostaglandin E2).
messages: Interacts with slc51b. The Ost-alpha/Ost-beta complex is a heterodimer composed of alpha (slc51a) and beta (slc51b) subunit (By similarity).
messages: Membrane

8364:ovos2
gene id: 8364:ovos2
uniprot id: F7DI46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8364:LOC101732885
gene id: 8364:LOC101732885
uniprot id: A0A8J1JEU6
uniprot id: A0A8J1JHA9
names: Similarity
messages: Belongs to the SEC2 family.

8364:LOC116406823
gene id: 8364:LOC116406823
uniprot id: A0A8J1IPU3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:me3
gene id: 8364:me3
uniprot id: A0A6I8Q7X5
uniprot id: A9JRL5
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

8364:nr1d1
gene id: 8364:nr1d1
uniprot id: A4IIE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

8364:LOC100491943
gene id: 8364:LOC100491943
uniprot id: A0A803J7I9
uniprot id: A0A8J1JIM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRRS1 family.
messages: Membrane

8364:LOC100486784
gene id: 8364:LOC100486784
uniprot id: A0A803KE74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8364:dmc1
gene id: 8364:dmc1
uniprot id: A0A6I8RXT0
names: Similarity
messages: Belongs to the RecA family. DMC1 subfamily.

8364:atp6v0d2
gene id: 8364:atp6v0d2
uniprot id: Q6P335
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). May play a role in coupling of proton transport and ATP hydrolysis (By similarity). Regulator of osteoclast fusion and bone formation (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

8364:rp1
gene id: 8364:rp1
uniprot id: A0A8J1JTU7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC100488390
gene id: 8364:LOC100488390
uniprot id: A0A8J1J523
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC116406730
gene id: 8364:LOC116406730
uniprot id: F7BGJ7
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

8364:dlg3
gene id: 8364:dlg3
uniprot id: A0A8J0SX20
uniprot id: L7N2V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Membrane

8364:fabp4
gene id: 8364:fabp4
uniprot id: A0A803KLC3
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

8364:ndufs5
gene id: 8364:ndufs5
uniprot id: A4QNJ5
uniprot id: F6XRW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Membrane
messages: Mitochondrion inner membrane

8364:svil
gene id: 8364:svil
uniprot id: A0A8J0SHD6
uniprot id: A0A8J0SHE2
uniprot id: A0A8J0SS96
uniprot id: A2VCZ3
uniprot id: F7A101
names: Similarity
messages: Belongs to the villin/gelsolin family.

8364:pdk3
gene id: 8364:pdk3
uniprot id: A9ULF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

8364:krt18.1
gene id: 8364:krt18.1
uniprot id: Q6P864
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the intermediate filament family.
messages: Heterotetramer of two type I and two type II keratins. Keratin-18 associates with keratin-8 (By similarity).
messages: Phosphorylated.
messages: Proteolytically cleaved by caspases during epithelial cell apoptosis.
messages: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
messages: When phosphorylated, plays a role in filament reorganization.

8364:slco1c1
gene id: 8364:slco1c1
uniprot id: A0A8J1J8U4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:dnal1
gene id: 8364:dnal1
uniprot id: Q28G94
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dynein light chain LC1-type family.
messages: Interacts with DNAH5, a outer arm dynein heavy chain. Interacts with tubulin located within the A-tubule of the outer doublets in a ATP-independent manner.
messages: Outer (ODAs) and inner (IDAs) dynein arms contain the molecular motors that generate the force to move cilia by ATP-dependent reactions. There are two mechanosensory systems that monitor and respond to the mechanical state (curvature) of the axoneme. One system involves the central pair microtubule complex and radial spokes and the second system involves the outer dynein arms.
messages: Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity).
messages: cilium axoneme

8364:LOC100497193
gene id: 8364:LOC100497193
uniprot id: A0A8J1IY54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

8364:txnrd2
gene id: 8364:txnrd2
uniprot id: A0A8J0QA84
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

8364:dner
gene id: 8364:dner
uniprot id: B1H2I7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:svep1l
gene id: 8364:svep1l
uniprot id: F6WI33
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC100490207
gene id: 8364:LOC100490207
uniprot id: A0A8J0QW92
uniprot id: A0A8J0T3F8
uniprot id: A0A8J1JPL6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:nipal1
gene id: 8364:nipal1
uniprot id: A0A803K4N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

8364:homer1
gene id: 8364:homer1
uniprot id: A0A8J0SYD9
uniprot id: A9JTQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

8364:coa7
gene id: 8364:coa7
uniprot id: B1WAQ3
uniprot id: Q0V9D9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: May be required for assembly of mitochondrial respiratory chain complexes.
messages: Mitochondrion intermembrane space
messages: Required for assembly of mitochondrial respiratory chain complexes.

8364:insm2
gene id: 8364:insm2
uniprot id: A0A8J0QMT8
names: Subcellular Location Annotation
messages: Nucleus

8364:taf5
gene id: 8364:taf5
uniprot id: B4F725
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

8364:nlgn3
gene id: 8364:nlgn3
uniprot id: A0A803K1S7
uniprot id: D2X2K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

8364:tnfaip6
gene id: 8364:tnfaip6
uniprot id: F7EDU7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:supt5h
gene id: 8364:supt5h
uniprot id: A0A8J0SVK2
uniprot id: F7EGJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT5 family.
messages: Nucleus

8364:LOC100495359
gene id: 8364:LOC100495359
uniprot id: A0A8J0R346
uniprot id: F6YPV9
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:atad2
gene id: 8364:atad2
uniprot id: A0A6I8RDE6
uniprot id: A0A8J1JQP9
names: Similarity
messages: Belongs to the AAA ATPase family.

8364:ak5
gene id: 8364:ak5
uniprot id: A0A803J3Y4
uniprot id: A0A8J1JCN5
uniprot id: A8KBE7
names: Similarity
messages: Belongs to the adenylate kinase family.

8364:LOC100497132
gene id: 8364:LOC100497132
uniprot id: A0A8J0R1Q6
names: Subcellular Location Annotation
messages: Membrane

8364:ifitm5
gene id: 8364:ifitm5
uniprot id: A0A803K8L7
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8364:pan3
gene id: 8364:pan3
uniprot id: A0A8J0SES1
uniprot id: A1L1C7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. PAN3 family.
messages: Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.
messages: Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the pan2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of pan2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.
messages: Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PABPC1 (via PABC domain), conferring substrate specificity of the enzyme complex. Interacts with the GW182 family proteins TNRC6A, TNRC6B and TNRC6C.
messages: Homodimer. Forms a heterotrimer with a catalytic subunit pan2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein pabpc1 (via PABC domain), conferring substrate specificity of the enzyme complex. Interacts with the GW182 family proteins tnrc6a, tnrc6b and tnrc6c.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: P-body
messages: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.
messages: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.
messages: The N-terminal zinc finger binds to poly(A) RNA.
messages: The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.
messages: The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for pan2.

8364:ifitm10
gene id: 8364:ifitm10
uniprot id: A0A6I8R217
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8364:rbp4
gene id: 8364:rbp4
uniprot id: F6UH11
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

8364:aebp1
gene id: 8364:aebp1
uniprot id: A0A6I8SCP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

8364:t2r41
gene id: 8364:t2r41
uniprot id: Q2AB46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:uqcr10
gene id: 8364:uqcr10
uniprot id: Q28ID4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

8364:slc1a2
gene id: 8364:slc1a2
uniprot id: A0A6I8SY96
uniprot id: A0A8J0R2Z9
uniprot id: A0A8J1JH09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

8364:nelfcd
gene id: 8364:nelfcd
uniprot id: Q566L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NELF-D family.
messages: Nucleus

8364:cers6
gene id: 8364:cers6
uniprot id: A0A803K034
uniprot id: F6ZS80
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

8364:st6gal1
gene id: 8364:st6gal1
uniprot id: A0A6I8RQD2
uniprot id: E4ZFH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8364:bscl2
gene id: 8364:bscl2
uniprot id: A0A803JGC0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:bora
gene id: 8364:bora
uniprot id: A0A6I8PVN9
uniprot id: A0A8J1J517
names: Similarity
messages: Belongs to the BORA family.

8364:unk
gene id: 8364:unk
uniprot id: A0A803K8W6
uniprot id: A0A8J0SQ58
uniprot id: Q4FZE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unkempt family.
messages: Cytoplasm

8364:capn7
gene id: 8364:capn7
uniprot id: A0A6I8QT93
uniprot id: A0A6I8R8L3
uniprot id: A0A8J0SUE6
uniprot id: A0A8J1JQ54
uniprot id: Q6NVT4
names: Similarity
messages: Belongs to the peptidase C2 family.

8364:sptbn2
gene id: 8364:sptbn2
uniprot id: A0A6I8Q3M7
uniprot id: A0A6I8R4I5
uniprot id: A0A8J0SD73
names: Similarity
messages: Belongs to the spectrin family.

8364:dhdds
gene id: 8364:dhdds
uniprot id: A9ULI1
names: Similarity
messages: Belongs to the UPP synthase family.

8364:pld6
gene id: 8364:pld6
uniprot id: Q28DT3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholipase D family. MitoPLD/Zucchini subfamily.
messages: Homodimer.
messages: In contrast to other members of the phospholipase D family, contains only one PLD phosphodiesterase domain, suggesting that it has a single half-catalytic and requires homodimerization to form a complete active site.
messages: Mitochondrion outer membrane
messages: Presents phospholipase and nuclease activities, depending on the different physiological conditions. Plays a key role in mitochondrial fusion and fission via its phospholipase activity. In its phospholipase role, it uses the mitochondrial lipid cardiolipin as substrate to generate phosphatidate (PA or 1,2-diacyl-sn-glycero-3-phosphate), a second messenger signaling lipid. Production of PA facilitates Mitofusin-mediated fusion, whereas the cleavage of PA by the Lipin family of phosphatases produces diacylgycerol (DAG) which promotes mitochondrial fission. Regulates mitochondrial shape through facilitating mitochondrial fusion. During spermatogenesis, plays a critical role in PIWI-interacting RNA (piRNA) biogenesis (By similarity). piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity (By similarity). Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as a phospholipase in some circumstances, this activity could not be confirmed (By similarity).

8364:adam23
gene id: 8364:adam23
uniprot id: A0A6I8QNJ9
uniprot id: A0A6I8SPR1
uniprot id: A0A6I8SUF6
uniprot id: A0A8J0SV93
uniprot id: A0A8J0T3L2
uniprot id: E2ICM1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:cacng3
gene id: 8364:cacng3
uniprot id: A0A6I8SSF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane

8364:psmd8
gene id: 8364:psmd8
uniprot id: A0A6I8RDQ3
uniprot id: Q6DEV4
names: Similarity
messages: Belongs to the proteasome subunit S14 family.

8364:naga
gene id: 8364:naga
uniprot id: A0A6R5A7S2
uniprot id: Q0P4I8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

8364:cd93
gene id: 8364:cd93
uniprot id: A0A8J0QT25
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:wt1
gene id: 8364:wt1
uniprot id: A0A6I8R6W0
uniprot id: A0A8J1JD14
uniprot id: A0A8J1JD20
uniprot id: B5DE03
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3' via its C2H2-type zinc fingers. Starting from the N-terminus, the second zinc finger binds to the 3'-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5'-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine, 5-formylcytosine or 5-carboxylcytosine.
messages: Cytoplasm
messages: Nucleus
messages: Nucleus speckle
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor required for development of the vascular component of the pronephric kidney, the glomus; may repress tubule-specific gene expression in the portion of the pronephros fated to form the glomus (By similarity). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (By similarity). Inhibits Wnt-signaling during embryonic development (By similarity).

8364:msh6
gene id: 8364:msh6
uniprot id: F7EDR7
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).

8364:ddx3x
gene id: 8364:ddx3x
uniprot id: A0A6I8R4B6
uniprot id: Q6P4J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family.
messages: Cytoplasm
messages: Nucleus

8364:pcsk6
gene id: 8364:pcsk6
uniprot id: A0A6I8QTT2
uniprot id: A0A8J0SZJ1
uniprot id: A0A8J1JEN7
names: Similarity
messages: Belongs to the peptidase S8 family.

8364:cdca8
gene id: 8364:cdca8
uniprot id: Q6GLC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the borealin family.
messages: Component of the CPC at least composed of survivin/birc5, incenp, cdca8/borealin and/or cdca9/dasra-A, and aurkb/aurora-B. Interacts with incenp (via N-terminus) (By similarity).
messages: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Contributes to CPC function by facilitating loading of the CPC onto chromosomes (By similarity).
messages: Nucleus
messages: centromere
messages: spindle

8364:LOC100496716
gene id: 8364:LOC100496716
uniprot id: A0A6I8QKH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

8364:ppp1r15b
gene id: 8364:ppp1r15b
uniprot id: A0A8J1JU45
names: Similarity
messages: Belongs to the PPP1R15 family.

8364:kcnq4
gene id: 8364:kcnq4
uniprot id: F6SB60
uniprot id: F6VAT6
uniprot id: Q0P4Q9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC116407704
gene id: 8364:LOC116407704
uniprot id: A0A803K907
uniprot id: A0A8J1IXD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8364:LOC733753
gene id: 8364:LOC733753
uniprot id: Q0D2E3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.
messages: Membrane
messages: Mitochondrion outer membrane

8364:tub
gene id: 8364:tub
uniprot id: A0A8J1JDB4
uniprot id: Q68FB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

8364:thada
gene id: 8364:thada
uniprot id: A0A8J1JIP4
uniprot id: F7CI08
names: Function
names: Similarity
messages: Belongs to the THADA family.
messages: Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs.

8364:atp13a3
gene id: 8364:atp13a3
uniprot id: A0A6I8QGG7
uniprot id: A0A6I8RET7
uniprot id: A0A8J1JMZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

8364:ftsj3
gene id: 8364:ftsj3
uniprot id: A0A8J0ST18
uniprot id: F6WUN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
messages: Interacts with NIP7.
messages: Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.
messages: nucleolus

8364:slc25a16
gene id: 8364:slc25a16
uniprot id: A0A8J1JW18
uniprot id: B5DEC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8364:rbm44
gene id: 8364:rbm44
uniprot id: A0A803K105
uniprot id: A0A8J0SX28
uniprot id: A0A8J1IU13
names: Subcellular Location Annotation
messages: Nucleus

8364:uxt
gene id: 8364:uxt
uniprot id: A0A803K2Y1
names: Similarity
messages: Belongs to the UXT family.

8364:LOC101735006
gene id: 8364:LOC101735006
uniprot id: A0A8J1J103
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:tagln
gene id: 8364:tagln
uniprot id: Q5BKM2
names: Similarity
messages: Belongs to the calponin family.

8364:rnf146
gene id: 8364:rnf146
uniprot id: Q66JE4
names: Domain
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated proteins. Neuroprotective protein. Protects against cell death induced by DNA damaging agents and rescues cells from G1 arrest. Promotes cell survival after gamma-irradiation. Facilitates DNA repair.
messages: Nucleus
messages: The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
messages: cytosol

8364:LOC100145331
gene id: 8364:LOC100145331
uniprot id: A0A6I8QM75
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:elk1
gene id: 8364:elk1
uniprot id: A0A803JH85
uniprot id: A0A803JWU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8364:p2rx2
gene id: 8364:p2rx2
uniprot id: A0A8J0QZB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

8364:rbbp8
gene id: 8364:rbbp8
uniprot id: A0A6I8PUS5
uniprot id: A0A6I8SXZ9
uniprot id: A0A8J1JNB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COM1/SAE2/CtIP family.
messages: Nucleus

8364:sgms1
gene id: 8364:sgms1
uniprot id: F6UTK5
uniprot id: Q640R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

8364:tbl3
gene id: 8364:tbl3
uniprot id: A4IH94
uniprot id: Q28DK2
names: Subcellular Location Annotation
messages: nucleolus

8364:LOC100492632
gene id: 8364:LOC100492632
uniprot id: A0A6I8QAK0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:slc25a15.2
gene id: 8364:slc25a15.2
uniprot id: A0A803KJG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8364:pofut1
gene id: 8364:pofut1
uniprot id: Q6EV71
names: Similarity
messages: Belongs to the glycosyltransferase 65 family.

8364:ube2e1
gene id: 8364:ube2e1
uniprot id: A0A8J1JMP2
uniprot id: Q6P837
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8364:vcan
gene id: 8364:vcan
uniprot id: A0A6I8RTQ2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:LOC116408759
gene id: 8364:LOC116408759
uniprot id: A0A8J1J3L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8364:htra4
gene id: 8364:htra4
uniprot id: A0A803JWS3
names: Similarity
messages: Belongs to the peptidase S1C family.

8364:LOC100135356
gene id: 8364:LOC100135356
uniprot id: A9UMH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

8364:inf2
gene id: 8364:inf2
uniprot id: Q0IHV1
names: Similarity
messages: Belongs to the formin homology family.

8364:ca6
gene id: 8364:ca6
uniprot id: Q0P4T9
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

8364:LOC116410437
gene id: 8364:LOC116410437
uniprot id: A0A8J1JG75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRRS1 family.
messages: Membrane

8364:gpcpd1
gene id: 8364:gpcpd1
uniprot id: B5DDX4
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

8364:ier5l
gene id: 8364:ier5l
uniprot id: Q6PBC9
names: Similarity
messages: Belongs to the IER family.

8364:p2rx4
gene id: 8364:p2rx4
uniprot id: A0A6I8SDW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

8364:fcf1
gene id: 8364:fcf1
uniprot id: Q6DIE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

8364:fmo5.1
gene id: 8364:fmo5.1
uniprot id: A0A6I8QHC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

8364:h3-3a
gene id: 8364:h3-3a
uniprot id: A9JTR4
uniprot id: Q6P823
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Monoubiquitinated by rag1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin. Phosphorylation on Ser-32 (H3S31ph) is specific to regions bordering centromeres in metaphase chromosomes.
messages: Serine ADP-ribosylation constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Specific interaction of trimethylated form at 'Lys-36' (H3.3K36me3) with zmynd11 is mediated by the encapsulation of Ser-32 residue with a composite pocket formed by the tandem bromo-PWWP domains.
messages: Specifically enriched in modifications associated with active chromatin such as methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with zmynd11; when trimethylated at 'Lys-36' (H3.3K36me3).
messages: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

8364:mtif2
gene id: 8364:mtif2
uniprot id: A0A803K1H0
uniprot id: A0A8J0QMW0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

8364:tlx3
gene id: 8364:tlx3
uniprot id: Q28CD6
names: Subcellular Location Annotation
messages: Nucleus

8364:nr0b1
gene id: 8364:nr0b1
uniprot id: F6ZB97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus

8364:thbs3
gene id: 8364:thbs3
uniprot id: Q5M7J5
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC116408930
gene id: 8364:LOC116408930
uniprot id: A0A8J1J9C8
names: Similarity
messages: Belongs to the MS4A family.

8364:armt1
gene id: 8364:armt1
uniprot id: A0A6I8RV51
uniprot id: A0A8J1J9H1
uniprot id: Q6DJA3
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
messages: Automethylated.
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Human C6orf211 has been reportedly associated with a protein carboxyl methyltransferase activity, but whether this protein indeed has such an activity remains to be determined (By similarity). It has been later shown to belong to a family of metal-dependent phosphatases implicated in metabolite damage-control (By similarity).
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (By similarity). Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (By similarity). Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues (By similarity). Possibly methylates PCNA, suggesting it is involved in the DNA damage response (By similarity).
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

8364:stag3
gene id: 8364:stag3
uniprot id: A0A6I8RR30
uniprot id: A0A8J1J6L4
uniprot id: B1H2R7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

8364:ccs
gene id: 8364:ccs
uniprot id: Q63ZZ7
names: Similarity
messages: In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.

8364:tff3.5
gene id: 8364:tff3.5
uniprot id: A0A8J1J101
uniprot id: A0A8J1J106
uniprot id: A0A8J1J3D1
uniprot id: A9UML2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:thra
gene id: 8364:thra
uniprot id: B3GR07
uniprot id: Q0EDH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

8364:c1h12orf43
gene id: 8364:c1h12orf43
uniprot id: A0A6I8RTQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUSTOS family.
messages: Nucleus envelope

8364:c11orf54
gene id: 8364:c11orf54
uniprot id: A0A8J0SEJ4
uniprot id: A0A8J1J1V7
uniprot id: A4IHG7
uniprot id: Q28GJ2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.
messages: Monomer.
messages: Nucleus

8364:npl
gene id: 8364:npl
uniprot id: Q5M905
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family. NanA subfamily.
messages: Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.
messages: Cytoplasm
messages: Homotetramer.

8364:plaa
gene id: 8364:plaa
uniprot id: A0A6I8QMC2
uniprot id: B1H2I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PLAP family.
messages: Cytoplasm

8364:LOC101731848
gene id: 8364:LOC101731848
uniprot id: A0A6I8QA59
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:LOC100498492
gene id: 8364:LOC100498492
uniprot id: A0A8J0T4B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:rbm5
gene id: 8364:rbm5
uniprot id: A0A8J0SGE7
uniprot id: A0A8J0SND3
uniprot id: A0A8J0SPX4
uniprot id: A0A8J0SR05
uniprot id: A0A8J0SR73
uniprot id: A4IGK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM5/RBM10 family.
messages: Component of the spliceosome A complex (also known as the prespliceosome). Appears to dissociate from the spliceosome upon formation of the spliceosome B complex (also known as the precatalytic spliceosome), in which the heterotrimeric U4/U6.U5 snRNPs are bound (By similarity).
messages: Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron (By similarity).
messages: Nucleus

8364:asf1b
gene id: 8364:asf1b
uniprot id: Q6DIP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ASF1 family.
messages: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.
messages: Interacts with histone H3 and histone H4.
messages: Nucleus

8364:d2hgdh
gene id: 8364:d2hgdh
uniprot id: A0A6I8SE28
uniprot id: A0A6I8SY54
uniprot id: A0A8J1JMZ9
names: Similarity
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.

8364:gjd4
gene id: 8364:gjd4
uniprot id: Q6P649
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8364:snap23
gene id: 8364:snap23
uniprot id: A9UL74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: synaptosome

8364:piezo2
gene id: 8364:piezo2
uniprot id: A0A8J0QNL9
uniprot id: A0A8J0SH22
uniprot id: A0A8J0SP08
uniprot id: A0A8J0SQM0
uniprot id: A0A8J0SRP0
uniprot id: A0A8J0SRW6
uniprot id: A0A8J1JNR7
uniprot id: A0A8J1JNR8
uniprot id: A0A8J1JSI1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIEZO (TC 1.A.75) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:tp53bp2
gene id: 8364:tp53bp2
uniprot id: F6U3J8
names: Subcellular Location Annotation
messages: Nucleus

8364:stra6
gene id: 8364:stra6
uniprot id: F6W823
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC100491930
gene id: 8364:LOC100491930
uniprot id: A0A8J0QJ10
uniprot id: A0A8J0SI14
uniprot id: A0A8J1JB36
names: Similarity
messages: Belongs to the CEMIP family.

8364:myh13
gene id: 8364:myh13
uniprot id: A0A803JXV6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:cops9
gene id: 8364:cops9
uniprot id: Q6DDA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN9 family.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity. May play a role in cell proliferation.
messages: Component of the CSN complex, probably composed of cops1, cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
messages: Cytoplasm
messages: Nucleus
messages: nucleoplasm

8364:irf8
gene id: 8364:irf8
uniprot id: A0A7D9NK55
names: Subcellular Location Annotation
messages: Nucleus

8364:sox4
gene id: 8364:sox4
uniprot id: Q28CP0
names: Subcellular Location Annotation
messages: Nucleus

8364:hoxd9
gene id: 8364:hoxd9
uniprot id: A0A803K0R1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

8364:LOC100496443
gene id: 8364:LOC100496443
uniprot id: A0A8J0SLH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100488963
gene id: 8364:LOC100488963
uniprot id: A0A8J1IZK5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:acat2
gene id: 8364:acat2
uniprot id: Q6P802
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

8364:homez
gene id: 8364:homez
uniprot id: A0A7D9NKX5
uniprot id: A0A803JL01
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100493684
gene id: 8364:LOC100493684
uniprot id: A0A8J0QYL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:kcnc4
gene id: 8364:kcnc4
uniprot id: A0A8J0QIF7
names: Subcellular Location Annotation
messages: Membrane

8364:LOC108648080
gene id: 8364:LOC108648080
uniprot id: A0A8J1K0V7
names: Subcellular Location Annotation
messages: Membrane

8364:snw1
gene id: 8364:snw1
uniprot id: Q28H99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNW family.
messages: Identified in the spliceosome C complex.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

8364:rpl28
gene id: 8364:rpl28
uniprot id: A0A803KGS5
uniprot id: F6XCL8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL28 family.

8364:cyld
gene id: 8364:cyld
uniprot id: A0A6I8SGS6
uniprot id: A0A8J0SHP2
uniprot id: B1H1A4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: centrosome
messages: cilium basal body
messages: perinuclear region
messages: spindle

8364:adgrl4
gene id: 8364:adgrl4
uniprot id: A0A6I8QPP0
uniprot id: A0A8J1JJA5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:crtc1
gene id: 8364:crtc1
uniprot id: A0A6I8Q3G2
uniprot id: A0A8J0T6W1
uniprot id: F6Y576
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TORC family.
messages: Cytoplasm
messages: Nucleus

8364:LOC101735111
gene id: 8364:LOC101735111
uniprot id: F6XTM2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:ptgs1
gene id: 8364:ptgs1
uniprot id: A0A6I8SVS9
uniprot id: F6PNE5
names: Caution
names: Similarity
messages: Belongs to the prostaglandin G/H synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:slc25a43
gene id: 8364:slc25a43
uniprot id: F6QGY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8364:LOC101732593
gene id: 8364:LOC101732593
uniprot id: A0A6I8RUJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Secreted

8364:xgb
gene id: 8364:xgb
uniprot id: Q5QSB2
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:sts
gene id: 8364:sts
uniprot id: A0A6I8RIF4
uniprot id: A0A8J1J3V7
uniprot id: A0A8J1J3W0
names: Similarity
messages: Belongs to the sulfatase family.

8364:lbx1
gene id: 8364:lbx1
uniprot id: Q0P4H6
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription factor that controls hypaxial muscle development by down-regulating myod1 and cdkn1b/p27, thereby allowing myoblasts to proliferate before the onset of terminal differentiation.

8364:hdac6
gene id: 8364:hdac6
uniprot id: A0A8J1IMR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Cytoplasm

8364:cox15
gene id: 8364:cox15
uniprot id: A0A6I8RSU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

8364:sox11
gene id: 8364:sox11
uniprot id: Q66JF1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with nlk.
messages: Nucleus
messages: Transcription factor that binds to the DNA sequence 5'-AACAAT-3' (By similarity). Acts as a transcriptional activator (By similarity). Plays a role together with nlk in neural induction during early embryogenesis (By similarity).

8364:entpd3
gene id: 8364:entpd3
uniprot id: A4IIK2
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

8364:LOC116409526
gene id: 8364:LOC116409526
uniprot id: A0A8J1J851
names: Subcellular Location Annotation
messages: Membrane

8364:npy1r
gene id: 8364:npy1r
uniprot id: F6ZME3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:zhx1
gene id: 8364:zhx1
uniprot id: F6SU96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

8364:slc13a3
gene id: 8364:slc13a3
uniprot id: A0A8J1IWG4
uniprot id: F6THH1
uniprot id: Q5EBF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

8364:cyp2c8l
gene id: 8364:cyp2c8l
uniprot id: A0A803KEV5
uniprot id: A0A8J0QGT1
uniprot id: A9JTU3
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:LOC100488380
gene id: 8364:LOC100488380
uniprot id: A0A8J0QW27
names: Similarity
messages: Belongs to the FXYD family.

8364:mgp
gene id: 8364:mgp
uniprot id: A0A803K263
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Requires vitamin K-dependent gamma-carboxylation for its function.
messages: Secreted

8364:pde4a
gene id: 8364:pde4a
uniprot id: A0A6I8QJT2
uniprot id: A0A6I8QUE3
uniprot id: A0A6I8SFY5
uniprot id: A0A6I8SNT1
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8364:atp1b1
gene id: 8364:atp1b1
uniprot id: Q5CZK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

8364:hspb2
gene id: 8364:hspb2
uniprot id: F7AAE2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

8364:tuba1cl.1
gene id: 8364:tuba1cl.1
uniprot id: A0A6I8R5I0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

8364:LOC116409653
gene id: 8364:LOC116409653
uniprot id: A0A8J1JC67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:fyttd1
gene id: 8364:fyttd1
uniprot id: A0A4X2QUZ6
uniprot id: A0A8J0SP29
uniprot id: A0A8J0T439
uniprot id: A0A8J1JIC1
uniprot id: Q28IB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UIF family.
messages: Nucleus speckle
messages: Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the ddx39b/uap56-nfx1 pathway to ensure efficient mRNA export and delivering to the nuclear pore (By similarity).
messages: nucleoplasm

8364:sema5b
gene id: 8364:sema5b
uniprot id: A0A8J1IT10
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:ttc39b
gene id: 8364:ttc39b
uniprot id: Q28DB0
names: Function
names: Similarity
messages: Belongs to the TTC39 family.
messages: May be involved in lipid metabolism.

8364:alg12
gene id: 8364:alg12
uniprot id: A0A8J0PGX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:LOC100488279
gene id: 8364:LOC100488279
uniprot id: A0A8J1JY69
uniprot id: A0A8J1JZS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

8364:inppl1
gene id: 8364:inppl1
uniprot id: A0A803J7U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
messages: Membrane
messages: Nucleus speckle
messages: filopodium
messages: lamellipodium

8364:frzb
gene id: 8364:frzb
uniprot id: Q6GLF7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

8364:ccna2
gene id: 8364:ccna2
uniprot id: Q6DIH8
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

8364:kif26b
gene id: 8364:kif26b
uniprot id: A0A8J0QJU2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8364:rimklb
gene id: 8364:rimklb
uniprot id: A0A803K8N2
names: Similarity
messages: Belongs to the RimK family.

8364:ccnt1
gene id: 8364:ccnt1
uniprot id: A0A8J0QHE2
uniprot id: A0A8J0SBU1
names: Similarity
messages: Belongs to the cyclin family.

8364:LOC100497033
gene id: 8364:LOC100497033
uniprot id: A0A803J7D9
names: Similarity
messages: Belongs to the cyclin family.

8364:mblac1
gene id: 8364:mblac1
uniprot id: A0A6I8QXI2
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

8364:tusc3
gene id: 8364:tusc3
uniprot id: A0A8J0QPZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:LOC108645668
gene id: 8364:LOC108645668
uniprot id: A0A8J0T193
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:ipo5
gene id: 8364:ipo5
uniprot id: A0A8J0SG22
uniprot id: Q0D2F3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:gmds
gene id: 8364:gmds
uniprot id: Q28GX4
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.

8364:tuba1cl.2
gene id: 8364:tuba1cl.2
uniprot id: A0A803KCS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

8364:osbpl9
gene id: 8364:osbpl9
uniprot id: A0A6I8S173
uniprot id: A0A7D9NKF7
uniprot id: A0A8J0SC39
uniprot id: A0A8J0SKH3
uniprot id: A0A8J0SLU2
uniprot id: A0A8J0T228
uniprot id: A0A8J0T2H8
uniprot id: A0A8J1JDU2
uniprot id: A0A8J1JDU7
uniprot id: A0A8J1JDV0
uniprot id: A0A8J1JGB5
uniprot id: A0A8J1JGC0
uniprot id: F7E4J1
uniprot id: Q0IJ05
names: Similarity
messages: Belongs to the OSBP family.

8364:penk
gene id: 8364:penk
uniprot id: A0A7D9NMD1
uniprot id: Q5FW03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Secreted

8364:t2r37
gene id: 8364:t2r37
uniprot id: Q2AB48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:cers4
gene id: 8364:cers4
uniprot id: A0A6I8PZY5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

8364:sncg
gene id: 8364:sncg
uniprot id: Q28F65
names: Similarity
names: Subunit
messages: Belongs to the synuclein family.
messages: May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation.

8364:plin3
gene id: 8364:plin3
uniprot id: A0A8J0SCH8
uniprot id: A0A8J0T6C5
uniprot id: F6Y0T8
names: Similarity
messages: Belongs to the perilipin family.

8364:myt1l
gene id: 8364:myt1l
uniprot id: A0A6I8QSG5
uniprot id: A0A6I8RJ62
uniprot id: A0A8J1JLF1
uniprot id: A0A8J1JLF6
uniprot id: A0A8J1JLG0
uniprot id: A0A8J1JLG3
uniprot id: A0A8J1JLG4
uniprot id: A0A8J1JLG8
uniprot id: A0A8J1JNV3
uniprot id: A0A8J1JQ25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

8364:LOC116410386
gene id: 8364:LOC116410386
uniprot id: A0A8J1JIX8
names: Similarity
messages: Belongs to the peptidase A1 family.

8364:gata5
gene id: 8364:gata5
uniprot id: A0A6I8QZS2
uniprot id: A0A803JC77
uniprot id: Q5M7L8
names: Subcellular Location Annotation
messages: Nucleus

8364:neurl4
gene id: 8364:neurl4
uniprot id: A1L0Y2
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers (By similarity).
messages: Ubiquitinated. This ubiquitination leads to proteasomal degradation (By similarity).
messages: centriole

8364:glg1
gene id: 8364:glg1
uniprot id: A0A6I8SB33
uniprot id: A0A8J0QHJ4
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Golgi outpost
messages: Membrane
messages: microtubule organizing center

8364:bag6
gene id: 8364:bag6
uniprot id: A0A8J0QGX7
uniprot id: A0A8J0SJW2
uniprot id: A0A8J0T5Y4
uniprot id: A4IH17
uniprot id: F6WJP7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the bag6/bat3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The bag6/bat3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Similarly, the bag6/bat3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The bag6/bat3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome. Also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. May ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress. By stabilizing a large spectrum of proteins, may indirectly affect different biological processes including apoptosis. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth…
messages: Component of the bag6/bat3 complex.
messages: Nucleus
messages: When nuclear, may also act as a component of some chromatin regulator complex.
messages: cytosol
messages: extracellular exosome

8364:kif17
gene id: 8364:kif17
uniprot id: A0A8J1JRL0
uniprot id: A0JPA3
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC101735070
gene id: 8364:LOC101735070
uniprot id: A0A803J9W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8364:idh3g
gene id: 8364:idh3g
uniprot id: F7D591
uniprot id: Q5BKK0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

8364:myh2
gene id: 8364:myh2
uniprot id: Q6DFQ6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:ptprm
gene id: 8364:ptprm
uniprot id: A0A8J1JP24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

8364:cdc42bpa
gene id: 8364:cdc42bpa
uniprot id: A0A6I8S9J9
uniprot id: A0A8J1JKN1
uniprot id: A0A8J1JKN9
uniprot id: A0A8J1JN33
uniprot id: A0A8J1JPA0
uniprot id: A0A8J1JPA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: lamellipodium

8364:tmem150c
gene id: 8364:tmem150c
uniprot id: A0A6I8PZ57
names: Subcellular Location Annotation
messages: Membrane

8364:crygdl.32
gene id: 8364:crygdl.32
uniprot id: A0A8J0QTI6
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:agps
gene id: 8364:agps
uniprot id: B1H1K4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
messages: Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.
messages: Homodimer.
messages: Peroxisome

8364:LOC100495980
gene id: 8364:LOC100495980
uniprot id: A0A803JNM7
uniprot id: A0A803K4H8
names: Similarity
messages: Belongs to the peptidase C2 family.

8364:kcnd3
gene id: 8364:kcnd3
uniprot id: A0A6I8PVA3
uniprot id: A4IIK9
names: Subcellular Location Annotation
messages: Membrane
messages: dendrite

8364:thbs1
gene id: 8364:thbs1
uniprot id: A0A6I8RQ44
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:btbd10
gene id: 8364:btbd10
uniprot id: A0A803KAE5
uniprot id: A0A8J1JGZ3
uniprot id: F6TDG6
names: Subcellular Location Annotation
messages: Cytoplasm

8364:grhpr.1
gene id: 8364:grhpr.1
uniprot id: A0A8J0PML4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

8364:alg3
gene id: 8364:alg3
uniprot id: A0A8J0SN70
uniprot id: A0A8J1JHJ8
uniprot id: F7CSE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
messages: Belongs to the glycosyltransferase 58 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:capza1
gene id: 8364:capza1
uniprot id: Q28DT1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

8364:birc5
gene id: 8364:birc5
uniprot id: Q28H51
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IAP family.
messages: C-terminus is required for spindle assembly.
messages: Component of the CPC at least composed of survivin/birc5, incenp, cdca8/borealin and/or cdca9/dasra-A, and aurkb/aurora-B. Interacts directly with incenp (via N-terminus), and may weakly interact with aurkb (via N-terminus) to stabilize the complex. Interacts with GTP-bound ran in both the S and M phases of the cell cycle. Also found in a complex with ubiquitin-mediated signaling proteins including at least usp9x/xFAM, nploc4/npl4 and ufd1 (By similarity).
messages: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Stimulates the mitotic kinase activity of aurkb/aurora-B in the CPC. Does not appear to exhibit anti-apoptotic activity (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Ubiquitination is required for centrosome-targeting.
messages: centromere
messages: spindle

8364:LOC116412077
gene id: 8364:LOC116412077
uniprot id: A0A803KC92
names: Caution
names: Similarity
messages: Belongs to the DMBT1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:ywhag
gene id: 8364:ywhag
uniprot id: F6TYX1
names: Function
names: Similarity
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
messages: Belongs to the 14-3-3 family.

8364:LOC100489408
gene id: 8364:LOC100489408
uniprot id: A0A8J0SMX0
uniprot id: F6TKY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

8364:LOC100491049
gene id: 8364:LOC100491049
uniprot id: A0A8J1IM69
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:tmem229b
gene id: 8364:tmem229b
uniprot id: A0A5S6KFZ0
uniprot id: Q0V9V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM229 family.
messages: Membrane

8364:gskip
gene id: 8364:gskip
uniprot id: A4IIW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSKIP family.
messages: Cytoplasm

8364:uncx
gene id: 8364:uncx
uniprot id: A0A8J0T6Q8
uniprot id: F6ZJQ2
names: Subcellular Location Annotation
messages: Nucleus

8364:grhpr.2
gene id: 8364:grhpr.2
uniprot id: Q66KM4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

8364:cd37
gene id: 8364:cd37
uniprot id: F6TSX2
uniprot id: Q5FVV2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:tctn3
gene id: 8364:tctn3
uniprot id: A0A8J0QTB4
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

8364:ptk2
gene id: 8364:ptk2
uniprot id: A0A6I8QVB5
uniprot id: A0A6I8QZP7
uniprot id: A0A803JXK4
uniprot id: A0A8J0R3X9
uniprot id: A0A8J0R4N3
uniprot id: A0A8J0SUZ7
uniprot id: A0A8J0SV02
uniprot id: A0A8J0T4E3
uniprot id: A0A8J0T4E8
uniprot id: A0A8J0T567
uniprot id: A0A8J1JQ14
uniprot id: A0A8J1JQ18
uniprot id: F7CW18
names: Subcellular Location Annotation
messages: Cell membrane
messages: focal adhesion

8364:bak1
gene id: 8364:bak1
uniprot id: A0A8J1J6P8
uniprot id: A0A8J1J7R7
names: Similarity
messages: Belongs to the Bcl-2 family.

8364:snx6
gene id: 8364:snx6
uniprot id: Q6P845
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

8364:sass6
gene id: 8364:sass6
uniprot id: F7CIV0
uniprot id: F7CJ32
uniprot id: Q28C08
names: Subcellular Location Annotation
messages: centrosome

8364:mrpl35
gene id: 8364:mrpl35
uniprot id: A0A8J0PJG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Mitochondrion

8364:rps10
gene id: 8364:rps10
uniprot id: A0A803KKY1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

8364:hdhd3
gene id: 8364:hdhd3
uniprot id: Q08CY5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

8364:gcfc2
gene id: 8364:gcfc2
uniprot id: A0A6I8PJ73
names: Similarity
messages: Belongs to the GCF family.

8364:LOC100488911
gene id: 8364:LOC100488911
uniprot id: A0A8J0QYE3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:ak8
gene id: 8364:ak8
uniprot id: Q6P618
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family.
messages: Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.
messages: cytosol

8364:psma4
gene id: 8364:psma4
uniprot id: Q66JK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

8364:kcng1
gene id: 8364:kcng1
uniprot id: A4IIL3
names: Subcellular Location Annotation
messages: Membrane

8364:LOC101730462
gene id: 8364:LOC101730462
uniprot id: A0A8J0R5S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC116407689
gene id: 8364:LOC116407689
uniprot id: A0A8J1IUW7
names: Subcellular Location Annotation
messages: Nucleus

8364:tom1l2
gene id: 8364:tom1l2
uniprot id: A0A6I8QDH2
uniprot id: A0A6I8SE74
uniprot id: A0A6I8SFW0
uniprot id: A0A8J0R567
uniprot id: A0A8J0R7F0
uniprot id: A0A8J1IWB6
names: Similarity
messages: Belongs to the TOM1 family.

8364:basp1
gene id: 8364:basp1
uniprot id: Q5XGB4
names: Similarity
messages: Belongs to the BASP1 family.

8364:LOC100485686
gene id: 8364:LOC100485686
uniprot id: A0A8J1J529
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:grik4
gene id: 8364:grik4
uniprot id: A0A6I8RC42
uniprot id: A0A6I8SET0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8364:ldah
gene id: 8364:ldah
uniprot id: A0A6I8PSP4
uniprot id: A0A8J1JLT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. LDAH family.
messages: Lipid droplet

8364:antxr1
gene id: 8364:antxr1
uniprot id: F6R0D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

8364:LOC100492345
gene id: 8364:LOC100492345
uniprot id: A0A8J1IZK8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC108644800
gene id: 8364:LOC108644800
uniprot id: A0A8J0SZ94
names: Subcellular Location Annotation
messages: Membrane

8364:rpf1
gene id: 8364:rpf1
uniprot id: Q28BW3
names: Subcellular Location Annotation
messages: nucleolus

8364:pigy
gene id: 8364:pigy
uniprot id: P0C1P1
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex composed at least by PIGA, PIGC, PIGH, PIGP, PIGQ, PIGY and DPM2.
messages: Endoplasmic reticulum membrane
messages: PREY is derived from the same bicistronic transcript that encodes these 2 different proteins.
messages: Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. May act by regulating the catalytic subunit PIGA.

8364:LOC108648817
gene id: 8364:LOC108648817
uniprot id: A0A8J1IZ20
names: Similarity
messages: Belongs to the ARTD/PARP family.

8364:pc.2
gene id: 8364:pc.2
uniprot id: A0A6I8SN43
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

8364:wwc2
gene id: 8364:wwc2
uniprot id: Q6DJR2
names: Similarity
messages: Belongs to the WWC family.

8364:LOC105945396
gene id: 8364:LOC105945396
uniprot id: A0A8J0SBM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100492630
gene id: 8364:LOC100492630
uniprot id: A0A803JLZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8364:avpr2
gene id: 8364:avpr2
uniprot id: F6XF22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane

8364:LOC116409852
gene id: 8364:LOC116409852
uniprot id: A0A803JD09
uniprot id: A0A8J1JC76
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

8364:cryba1
gene id: 8364:cryba1
uniprot id: A4QNM6
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:chsy1
gene id: 8364:chsy1
uniprot id: F7BVZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

8364:LOC100127850
gene id: 8364:LOC100127850
uniprot id: Q07FY4
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

8364:LOC100488176
gene id: 8364:LOC100488176
uniprot id: A0A8J1IXY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

8364:LOC100497496
gene id: 8364:LOC100497496
uniprot id: A0A8J0QUR7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:sf3b6
gene id: 8364:sf3b6
uniprot id: Q28J16
names: Subcellular Location Annotation
messages: Nucleus

8364:slc6a17
gene id: 8364:slc6a17
uniprot id: F6QY29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8364:LOC101732673
gene id: 8364:LOC101732673
uniprot id: A0A8J0SRP2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC100494776
gene id: 8364:LOC100494776
uniprot id: A0A8J0SK08
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:snx19
gene id: 8364:snx19
uniprot id: A0A8J0SSZ1
uniprot id: A0A8J0T4M8
names: Similarity
messages: Belongs to the sorting nexin family.

8364:dynlt3
gene id: 8364:dynlt3
uniprot id: A0A8J0QYH5
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

8364:galns
gene id: 8364:galns
uniprot id: A0A6I8QGZ3
uniprot id: A0A8J0SLE9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Homodimer.
messages: Lysosome

8364:cadm3
gene id: 8364:cadm3
uniprot id: A0A6I8QUF1
uniprot id: A0A6I8RHG9
names: Similarity
messages: Belongs to the nectin family.

8364:LOC100492274
gene id: 8364:LOC100492274
uniprot id: A0A6I8S211
uniprot id: A0A8J1JR17
names: Subcellular Location Annotation
messages: Membrane

8364:atp8a1
gene id: 8364:atp8a1
uniprot id: A0A6I8Q7C8
uniprot id: A0A6I8QQP1
uniprot id: F7AEB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

8364:reep2
gene id: 8364:reep2
uniprot id: A0A5K1UQR0
uniprot id: A0A8J0S8S4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:ubr1
gene id: 8364:ubr1
uniprot id: A0A7D9N0A0
uniprot id: A0A8J0SM06
uniprot id: A0A8J0SU58
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

8364:ppp1r1a
gene id: 8364:ppp1r1a
uniprot id: A0A8J0SCI1
uniprot id: A0A8J1J458
uniprot id: B7ZSS4
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

8364:stard8
gene id: 8364:stard8
uniprot id: A0A6I8RWS2
uniprot id: A0A6I8ST67
uniprot id: A0A8J0R5P3
names: Subcellular Location Annotation
messages: Cytoplasm

8364:steap2
gene id: 8364:steap2
uniprot id: F6YGT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

8364:LOC100485245
gene id: 8364:LOC100485245
uniprot id: A0A8J0R3V5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:LOC100487169
gene id: 8364:LOC100487169
uniprot id: A0A1B8Y8Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC108647649
gene id: 8364:LOC108647649
uniprot id: A0A8J1JND4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:gtf2h2
gene id: 8364:gtf2h2
uniprot id: Q5XGG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTF2H2 family.
messages: Nucleus

8364:cep19
gene id: 8364:cep19
uniprot id: A9UL78
uniprot id: B7ZU71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP19 family.
messages: Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation.
messages: centriole
messages: cilium basal body
messages: spindle pole

8364:plp1
gene id: 8364:plp1
uniprot id: A0A803K714
uniprot id: Q4QQQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

8364:ap3s2
gene id: 8364:ap3s2
uniprot id: A0A8J0SI97
uniprot id: Q5RJU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

8364:ptpn4
gene id: 8364:ptpn4
uniprot id: A0A8J1ISU1
uniprot id: F6X7I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

8364:calu
gene id: 8364:calu
uniprot id: Q28BT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CREC family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus
messages: Interacts with ggcx.
messages: Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase ggcx. Binds 7 calcium ions with a low affinity (By similarity).
messages: Melanosome
messages: Sarcoplasmic reticulum lumen
messages: Secreted

8364:itgav
gene id: 8364:itgav
uniprot id: A0A6I8QC93
uniprot id: B1WAV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

8364:mtor
gene id: 8364:mtor
uniprot id: A0A8J1JWG6
uniprot id: A0A8J1JXU0
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

8364:LOC100495988
gene id: 8364:LOC100495988
uniprot id: B0JZ06
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:abhd12
gene id: 8364:abhd12
uniprot id: B4F753
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serine esterase family.
messages: Endoplasmic reticulum membrane
messages: Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (By similarity). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (By similarity).

8364:nasp
gene id: 8364:nasp
uniprot id: A0A8J0SKD6
uniprot id: B5DFR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NASP family.
messages: Nucleus

8364:LOC100495968
gene id: 8364:LOC100495968
uniprot id: A0A8J0QML7
uniprot id: A0A8J0R3P3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:erfl
gene id: 8364:erfl
uniprot id: A0A8J0R577
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8364:LOC116412168
gene id: 8364:LOC116412168
uniprot id: A0A8J1JUV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC101731682
gene id: 8364:LOC101731682
uniprot id: F6ZIL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

8364:tsc22d1
gene id: 8364:tsc22d1
uniprot id: A0A6I8PWQ1
uniprot id: A0A6I8QXD0
uniprot id: A0A8J0SFS5
uniprot id: B1H3H3
uniprot id: Q5BL80
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

8364:LOC100495385
gene id: 8364:LOC100495385
uniprot id: A0A803JRM0
uniprot id: A0A803JYK7
uniprot id: A0A8J1JVN7
uniprot id: A0A8J1JZP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8364:LOC101734592
gene id: 8364:LOC101734592
uniprot id: A0A8J0R237
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:zfyve28
gene id: 8364:zfyve28
uniprot id: A0A6I8S1S0
uniprot id: Q0P4S0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lst-2 family.
messages: Early endosome membrane
messages: Monoubiquitination at Lys-87 prevents binding to phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes.
messages: Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated (By similarity).
messages: The FYVE-type zinc finger mediates the interaction with phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes when not monoubiquitinated at Lys-87.
messages: cytosol

8364:dusp26
gene id: 8364:dusp26
uniprot id: F7BTI8
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

8364:tfip11
gene id: 8364:tfip11
uniprot id: A0A8J1JEY6
uniprot id: Q0IIX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFP11/STIP family.
messages: Identified in the spliceosome C complex.
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events.
messages: Nucleus

8364:cul2
gene id: 8364:cul2
uniprot id: A0A6I8SHI2
uniprot id: F6VLY7
names: Similarity
messages: Belongs to the cullin family.

8364:fut6.2
gene id: 8364:fut6.2
uniprot id: F6SLM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

8364:odf2
gene id: 8364:odf2
uniprot id: A4IHP0
uniprot id: F6UJC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF2 family.
messages: centrosome

8364:engase
gene id: 8364:engase
uniprot id: A0A7D9NLE4
uniprot id: A0A803JGM5
uniprot id: A0A803JQ80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 85 family.
messages: cytosol

8364:LOC108648862
gene id: 8364:LOC108648862
uniprot id: F7C6D9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:desi2l
gene id: 8364:desi2l
uniprot id: A0A6I8SWQ4
names: Similarity
messages: Belongs to the DeSI family.

8364:hsp90aa1.1
gene id: 8364:hsp90aa1.1
uniprot id: A0A6I8Q4N0
names: Similarity
messages: Belongs to the heat shock protein 90 family.

8364:cchcr1
gene id: 8364:cchcr1
uniprot id: A0A8J0SUT9
uniprot id: B0JZ34
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a regulator of keratinocyte proliferation or differentiation.
messages: Nucleus

8364:pnoc
gene id: 8364:pnoc
uniprot id: A8WGY6
uniprot id: F7CDP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Secreted

8364:dusp6
gene id: 8364:dusp6
uniprot id: Q28E94
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

8364:hoxc11
gene id: 8364:hoxc11
uniprot id: A0A8J0QSF9
uniprot id: A0A8J1J5B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

8364:il10rb
gene id: 8364:il10rb
uniprot id: D2DJQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.

8364:LOC100492502
gene id: 8364:LOC100492502
uniprot id: A0A8J0QQX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:plpbp
gene id: 8364:plpbp
uniprot id: A0A6I8PQX2
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

8364:elovl1
gene id: 8364:elovl1
uniprot id: Q28IH0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL1 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

8364:slc25a20l
gene id: 8364:slc25a20l
uniprot id: A0A803JL99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8364:rapgef6
gene id: 8364:rapgef6
uniprot id: A0A6I8QAH6
uniprot id: A0A6I8R0N6
uniprot id: A0A6I8S7M4
uniprot id: A0A8J0SS41
uniprot id: A0A8J0T137
uniprot id: A0A8J0T2C1
uniprot id: A0A8J0T2C6
uniprot id: F7E820
uniprot id: F7E827
names: Similarity
messages: Belongs to the RAPGEF2 family.

8364:atg2a
gene id: 8364:atg2a
uniprot id: Q08D51
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG2 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Lipid transfer protein involved in autophagosome assembly. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to atg9 (atg9a or atg9b) to the IM for membrane expansion. Also regulates lipid droplets morphology and distribution within the cell.
messages: Preautophagosomal structure membrane
messages: The chorein N-terminal domain mediates lipid transfer activity.

8364:higd2a
gene id: 8364:higd2a
uniprot id: A0A6I8RRB9
uniprot id: A9JSE3
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

8364:naxd
gene id: 8364:naxd
uniprot id: A0A6I8RHR0
uniprot id: A0A803J9P2
uniprot id: A0A8J0S7L8
uniprot id: A0A8J0SCK4
uniprot id: F6QZG8
uniprot id: Q0IIW2
names: Function
names: Similarity
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.

8364:nmt1
gene id: 8364:nmt1
uniprot id: F6XYJ0
names: Function
names: Similarity
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.

8364:dydc1
gene id: 8364:dydc1
uniprot id: F6URR2
names: Similarity
messages: Belongs to the dpy-30 family.

8364:atm
gene id: 8364:atm
uniprot id: A0A6I8QJJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.
messages: Nucleus

8364:LOC100124950
gene id: 8364:LOC100124950
uniprot id: A0A8J1JLX4
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:LOC108648283
gene id: 8364:LOC108648283
uniprot id: A0A8J0T331
names: Subcellular Location Annotation
messages: Membrane

8364:brms1
gene id: 8364:brms1
uniprot id: A0A803K4R0
names: Subcellular Location Annotation
messages: Nucleus

8364:sox10
gene id: 8364:sox10
uniprot id: A4IIJ8
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acts early in neural crest formation, functioning redundantly with the other group E Sox factors sox8 and sox9 to induce neural crest progenitors. Acts downstream of wnt-signaling at the neural plate border. Involved in the specification of neural crest progenitors fated to form the pigment cell lineage (By similarity).
messages: Cytoplasm
messages: Interacts with the sumoylation factors ube2i/ubc9 and sumo1.
messages: Nucleus
messages: Sumoylated.
messages: The transactivation domains TAM and TAC (for transactivation domain in the middle and at the C-terminus, respectively) are required to contact transcriptional coactivators and basal transcriptional machinery components and thereby induce gene transactivation.

8364:lrpprc
gene id: 8364:lrpprc
uniprot id: Q28C74
names: Function
names: Subcellular Location Annotation
messages: May play a role in RNA metabolism in both nuclei and mitochondria. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. May be involved in transcription regulation. Binds single-stranded DNA (By similarity).
messages: Mitochondrion
messages: Nucleus

8364:thumpd2
gene id: 8364:thumpd2
uniprot id: A8E5T2
uniprot id: F6R2E5
names: Similarity
messages: Belongs to the methyltransferase superfamily.

8364:LOC116410963
gene id: 8364:LOC116410963
uniprot id: A0A8J1JL05
names: Similarity
messages: Belongs to the vinculin/alpha-catenin family.

8364:polr2f
gene id: 8364:polr2f
uniprot id: Q6DDA6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: Nucleus

8364:kdm7a
gene id: 8364:kdm7a
uniprot id: Q08D35
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (By similarity).
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3. Binding to H3K4me3 prevents its access to H3K9me2 (By similarity).

8364:mogat2.2
gene id: 8364:mogat2.2
uniprot id: F7DA91
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:spc24
gene id: 8364:spc24
uniprot id: A0A8J1J6Z8
uniprot id: Q6P8A1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
messages: Belongs to the SPC24 family.
messages: Component of the NDC80 complex, which is composed of ndc80, cdca1, spbc24 and spbc25. The NDC80 complex interacts with mis12 and zwint (By similarity).
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

8364:ncln
gene id: 8364:ncln
uniprot id: Q5BJ70
names: Function
names: Similarity
messages: Belongs to the nicastrin family.
messages: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.

8364:ndst2
gene id: 8364:ndst2
uniprot id: F6Z353
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

8364:papolg
gene id: 8364:papolg
uniprot id: A0A803KGM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Nucleus

8364:csad
gene id: 8364:csad
uniprot id: A0A6I8RDR3
names: Similarity
messages: Belongs to the group II decarboxylase family.

8364:ubxn1
gene id: 8364:ubxn1
uniprot id: Q6GL77
names: Function
names: Subcellular Location Annotation
messages: Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in ubiquitin-proteasome systems (By similarity).
messages: Cytoplasm

8364:LOC100497808
gene id: 8364:LOC100497808
uniprot id: A0A8J1IQ98
uniprot id: L7N3N3
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:LOC100494570
gene id: 8364:LOC100494570
uniprot id: A0A6I8RAX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

8364:prkcb
gene id: 8364:prkcb
uniprot id: A0A6I8SS53
uniprot id: A8KBH6
names: Activity Regulation
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Activated by diacylglycerol which in turn phosphorylates a range of cellular proteins.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.
messages: Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell survival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of card11/carma1, leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates isoform p66Shc of shc1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (andr)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation (By similarity).
messages: Cytoplasm
messages: Membrane
messages: Nucleus
messages: Phosphorylation on Thr-497 within the activation loop renders it competent to autophosphorylate. Subsequent autophosphorylation of Thr-638 maintains catalytic competence, and autophosphorylation on Ser-657 appears to release the kinase into the cytosol (By similarity).

8364:erf
gene id: 8364:erf
uniprot id: Q5EB35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8364:tmem198
gene id: 8364:tmem198
uniprot id: A0A4X2QQI2
uniprot id: Q6DFQ7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM198 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Expression widely distributed both maternally and zygotically. During gastrulation, strong expression in the posterior end near the blastopore.
messages: Interacts with lrp6. Interacts with casein kinases.
messages: Membrane
messages: Morphants have defects in neural crest formation. At the tadpole stage, animals are often less pigmented with ventrally bent tails. Embryos develop smaller eyes and forebrain structures.
messages: Promotes lrp6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of lrp6 further enhancing its activity. Required for neural crest formation.

8364:kansl2
gene id: 8364:kansl2
uniprot id: A4IHJ7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
messages: Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.
messages: Nucleus

8364:LOC101734009
gene id: 8364:LOC101734009
uniprot id: A0A8J0SPN5
names: Subcellular Location Annotation
messages: Membrane
messages: Sarcoplasmic reticulum membrane

8364:LOC116409597
gene id: 8364:LOC116409597
uniprot id: A0A8J1J8J2
names: Subcellular Location Annotation
messages: Membrane

8364:nxt2
gene id: 8364:nxt2
uniprot id: L7MUI1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

8364:prdm5
gene id: 8364:prdm5
uniprot id: A0A7D9N0C2
uniprot id: A0A8J0T2X9
names: Subcellular Location Annotation
messages: Nucleus

8364:spr
gene id: 8364:spr
uniprot id: A0A803K5T0
uniprot id: A0A8J1IZB1
uniprot id: B0BML7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sepiapterin reductase family.
messages: Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
messages: Cytoplasm
messages: Homodimer.

8364:prr5
gene id: 8364:prr5
uniprot id: A0A803K2W5
uniprot id: A0A803K9N5
uniprot id: A0A8J0PES7
uniprot id: A0A8J1J776
uniprot id: A0A8J1J9L6
uniprot id: Q66JH5
names: Similarity
messages: Belongs to the PROTOR family.

8364:LOC100494508
gene id: 8364:LOC100494508
uniprot id: F7DEB8
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:slc7a3
gene id: 8364:slc7a3
uniprot id: A0A6I8PP29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

8364:mars1
gene id: 8364:mars1
uniprot id: A0A6I8SGI0
uniprot id: B4F6J9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

8364:gabra6
gene id: 8364:gabra6
uniprot id: A0A7D9NMA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:dmrt3
gene id: 8364:dmrt3
uniprot id: R4HHX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

8364:dvl2
gene id: 8364:dvl2
uniprot id: Q05AS8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DSH family.
messages: Can form homomultimers. Interacts with prickle1. Interacts (via the PDZ domain) with ccdc88c/dal and dact1-B/dpr. Interacts (via the DIX domain) with ARP/Axin-related protein and dact1-A/frodo. Interacts with sdc4, possibly via fz7. Interacts directly (via the DEP domain) with efnb1/ephrin-B1. May interact indirectly with the phosphorylated ephrin receptors ephb1 and ephb2 via SH domain-containing adapters (By similarity).
messages: Cell membrane
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Involved in at least 2 independent signaling cascades, controlling cell fate via canonical Wnt signaling and cell polarity via a planar cell polarity (PCP) cascade. Acts synergistically with dal/dapple-like to activate Wnt signaling, stabilizing ctnnb1/beta-catenin and leading to dorsal axis formation. Also prevents degradation of ctnnb1/beta-catenin by displacing gsk3 from a complex with ARP/Axin-related protein. Has an additional role in anterior-posterior (A/P) axis formation, specifying different neuroectodermal cell fates along the A/P axis in a dose-dependent manner by activating several early patterning genes. In the PCP pathway, required at the cell membrane for PCP-mediated neural and mesodermal convergent extension during gastrulation and subsequent neural tube closure, acting to activate jnk. Also involved in blastopore closure and archenteron elongation during early, but not late, gastrulation. Associates with ephrin receptors and ligands and acts as part of a downstream PCP pathway to mediate ephrin-mediated cell repulsion via activation of rhoa. Required for efnb1/ephrin-B1-driven movement of non-retinal progenitor cells into the retina during eye field formation. Patterns the hindbrain. Required for ciliogenesis. Controls the docking of basal bodies to the apical plasma membrane; mediates the activation, but not localization of rhoa at the apical surface of ciliated cells during basal body docking. Furthermore, required for the association of basal bodies with membrane-bound vesicles and the vesicle-trafficking protein exoc4/sec8, and this association is in turn required for basal body docking. Once basal bodies are docked, required for the planar polarization of basal bodies that underlies ciliary beating and the directional fluid flow across ciliated epithelia (By similarity).
messages: Nucleus
messages: Phosphorylated. Phosphorylation is controlled by frizzled proteins, correlates with the onset of embryo dorsalizing events and is higher in the dorsal half of early cleavage embryos. Phosphorylated on tyrosine residues in response to association with efnb1/ephrin-B1 (By similarity).
messages: The C-terminal region containing the DEP domain is required for membrane accumulation and phosphorylation. Wnt signaling and axis induction requires the DIX domain. The C-terminus contributes to the localization at the cilia base (By similarity).
messages: cilium

8364:LOC100493251
gene id: 8364:LOC100493251
uniprot id: A0A8J0T0X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

8364:LOC108645833
gene id: 8364:LOC108645833
uniprot id: A0A8J1J3F6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC733556
gene id: 8364:LOC733556
uniprot id: A0A803JZF4
uniprot id: Q28GK5
names: Similarity
messages: Belongs to the MS4A family.

8364:khdrbs2
gene id: 8364:khdrbs2
uniprot id: A0A8J1JIE1
uniprot id: Q0VFL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KHDRBS family.
messages: Nucleus
messages: RNA-binding protein that plays a role in the regulation of alternative splicing.

8364:adora2a
gene id: 8364:adora2a
uniprot id: A7MC54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

8364:dctn4
gene id: 8364:dctn4
uniprot id: A0A8J0SIN5
uniprot id: Q561P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunit 4 family.
messages: cell cortex
messages: centrosome
messages: sarcomere
messages: stress fiber

8364:stc2
gene id: 8364:stc2
uniprot id: A0A803KHX5
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

8364:dtd1
gene id: 8364:dtd1
uniprot id: B1H1C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DTD family.
messages: Cytoplasm

8364:kmt5c
gene id: 8364:kmt5c
uniprot id: A0A8J0SQ19
uniprot id: B1WB46
names: Subcellular Location Annotation
messages: Nucleus

8364:hoxd4
gene id: 8364:hoxd4
uniprot id: F6VY66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

8364:uchl3
gene id: 8364:uchl3
uniprot id: A0A8J1J1Y5
uniprot id: Q28GY5
names: Similarity
messages: Belongs to the peptidase C12 family.

8364:LOC100498522
gene id: 8364:LOC100498522
uniprot id: A0A6I8PWL3
uniprot id: A0A8J0T4W3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

8364:phf5a
gene id: 8364:phf5a
uniprot id: B3DL60
names: Similarity
messages: Belongs to the PHF5 family.

8364:LOC100497984
gene id: 8364:LOC100497984
uniprot id: A0A8J1ITR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:bet1
gene id: 8364:bet1
uniprot id: Q28H66
names: Subcellular Location Annotation
messages: Membrane

8364:LOC116406764
gene id: 8364:LOC116406764
uniprot id: A0A8J1IPH8
names: Similarity
messages: Belongs to the peptidase C1 family.

8364:LOC100489019
gene id: 8364:LOC100489019
uniprot id: A0A8J0QTV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:arrdc4
gene id: 8364:arrdc4
uniprot id: B0BM25
names: Similarity
messages: Belongs to the arrestin family.

8364:egfr
gene id: 8364:egfr
uniprot id: F6UFM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

8364:efnb1
gene id: 8364:efnb1
uniprot id: F7B9D9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:hyls1
gene id: 8364:hyls1
uniprot id: A0A6I8RYD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYLS1 family.
messages: centriole
messages: cilium

8364:LOC116409560
gene id: 8364:LOC116409560
uniprot id: A0A8J1JBS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:crygdl.39
gene id: 8364:crygdl.39
uniprot id: A0A8J0QTJ1
uniprot id: A0A8J0QYR9
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:LOC101731190
gene id: 8364:LOC101731190
uniprot id: A0A6I8PQY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:zic5
gene id: 8364:zic5
uniprot id: F7AK26
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

8364:snx25
gene id: 8364:snx25
uniprot id: A0A6I8PXS4
uniprot id: A0A8J0T4U1
uniprot id: A0A8J1J0C1
names: Similarity
messages: Belongs to the sorting nexin family.

8364:bco1
gene id: 8364:bco1
uniprot id: A0A6I8Q6F5
names: Cofactor
names: Similarity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.

8364:nup107
gene id: 8364:nup107
uniprot id: A0A8J0QPV6
uniprot id: F7C7D6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup84/Nup107 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC).
messages: nuclear pore complex

8364:cyp46a1.2
gene id: 8364:cyp46a1.2
uniprot id: Q0P4I6
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:MGC79725
gene id: 8364:MGC79725
uniprot id: Q6DFP5
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

8364:fxyd2
gene id: 8364:fxyd2
uniprot id: B1H356
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FXYD family.
messages: May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
messages: Membrane
messages: Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.

8364:LOC116407761
gene id: 8364:LOC116407761
uniprot id: A0A8J1IXW6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Nematocyst
messages: Target cell membrane

8364:sbk1l
gene id: 8364:sbk1l
uniprot id: F6ZIA8
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:bclaf3
gene id: 8364:bclaf3
uniprot id: A0A6I8PMG9
uniprot id: A0A8J1J7G5
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

8364:LOC116408078
gene id: 8364:LOC116408078
uniprot id: A0A8J1IYS7
names: Subcellular Location Annotation
messages: Nucleus

8364:myh8
gene id: 8364:myh8
uniprot id: A0A6I8SWU8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:ophn1
gene id: 8364:ophn1
uniprot id: Q0P4U1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Postsynapse
messages: Presynapse
messages: dendrite

8364:galnt4
gene id: 8364:galnt4
uniprot id: Q08CX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8364:rpl17
gene id: 8364:rpl17
uniprot id: Q6DEU4
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

8364:nadsyn1
gene id: 8364:nadsyn1
uniprot id: A0A803KL75
names: Similarity
names: Subunit
messages: Homohexamer.
messages: In the C-terminal section; belongs to the NAD synthetase family.

8364:hoxd1
gene id: 8364:hoxd1
uniprot id: Q28IU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Acts downstream of meis3 to pattern the hindbrain (By similarity).

8364:gfod2
gene id: 8364:gfod2
uniprot id: Q5BKK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Gfo/Idh/MocA family.
messages: Promotes matrix assembly.
messages: extracellular matrix

8364:zdhhc17
gene id: 8364:zdhhc17
uniprot id: A0A8J0QRH5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8364:LOC116409548
gene id: 8364:LOC116409548
uniprot id: A0A8J1JAP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:sirt5
gene id: 8364:sirt5
uniprot id: F7DKV7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-101 and Arg-104) that bind to malonylated and succinylated substrates and define the specificity.
messages: Mitochondrion
messages: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.
messages: Nucleus
messages: cytosol

8364:slc16a12
gene id: 8364:slc16a12
uniprot id: F6ZTR2
uniprot id: Q6P2X9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Functions as a transporter for creatine and as well for its precursor guanidinoacetate. Transport of creatine and GAA is independent of resting membrane potential and extracellular Na(+), Cl(-), or pH. Contributes to the process of creatine biosynthesis and distribution.
messages: Membrane

8364:LOC101732876
gene id: 8364:LOC101732876
uniprot id: A0A803KD42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:gabra3
gene id: 8364:gabra3
uniprot id: A0A8J1ITF3
uniprot id: F6Y079
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:cyp2g1p
gene id: 8364:cyp2g1p
uniprot id: F6UVV5
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:LOC100489735
gene id: 8364:LOC100489735
uniprot id: A0A8J0QKC7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

8364:rec8
gene id: 8364:rec8
uniprot id: A0A8J1JIV3
uniprot id: A0A8J1JLA3
uniprot id: A0A8J1JLB1
uniprot id: A0A8J1JME2
uniprot id: Q0IHT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

8364:trpv1
gene id: 8364:trpv1
uniprot id: A0A6I8T2G1
uniprot id: H3K2J6
names: Subcellular Location Annotation
messages: Membrane

8364:scg5
gene id: 8364:scg5
uniprot id: A0A8J0PKZ4
uniprot id: Q0VFS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 7B2 family.
messages: Secreted

8364:LOC101732872
gene id: 8364:LOC101732872
uniprot id: A0A803J724
names: Similarity
messages: Belongs to the cyclin family.

8364:axl
gene id: 8364:axl
uniprot id: A0JP83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cell membrane
messages: Membrane

8364:elovl3
gene id: 8364:elovl3
uniprot id: A0A803JRC2
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL6 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.

8364:abcd4
gene id: 8364:abcd4
uniprot id: A0A8J0QV29
uniprot id: A0A8J0SW64
uniprot id: A0A8J0SWV9
uniprot id: A0A8J0T5G0
names: Subcellular Location Annotation
messages: Membrane

8364:LOC116411014
gene id: 8364:LOC116411014
uniprot id: A0A8J1JL82
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC101732966
gene id: 8364:LOC101732966
uniprot id: A0A8J0R2Y9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:pla2g2e
gene id: 8364:pla2g2e
uniprot id: F6Z7M8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

8364:oxsr1
gene id: 8364:oxsr1
uniprot id: F7BZ31
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

8364:LOC100493003
gene id: 8364:LOC100493003
uniprot id: A0A8J0QU56
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100485327
gene id: 8364:LOC100485327
uniprot id: A0A8J1J0J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

8364:napg
gene id: 8364:napg
uniprot id: A9UMI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

8364:LOC116407570
gene id: 8364:LOC116407570
uniprot id: A0A8J1ITL4
uniprot id: A0A8J1ITM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:astl2g
gene id: 8364:astl2g
uniprot id: F6ZRI3
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:rab5if
gene id: 8364:rab5if
uniprot id: Q5BJ57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:mmp25
gene id: 8364:mmp25
uniprot id: F7BXU6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

8364:LOC116406801
gene id: 8364:LOC116406801
uniprot id: A0A8J1IS58
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:rpl18a
gene id: 8364:rpl18a
uniprot id: F6Y9Q4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

8364:usp44
gene id: 8364:usp44
uniprot id: A0A8J0SV49
uniprot id: F7DQH6
uniprot id: Q0V9G5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Belongs to the peptidase C19 family. USP44 subfamily.
messages: Deubiquitinase that plays a key role in the spindle checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of cdc20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C) (By similarity).
messages: Nucleus

8364:yy1
gene id: 8364:yy1
uniprot id: F6VSC6
names: Similarity
messages: Belongs to the YY transcription factor family.

8364:ddr2l
gene id: 8364:ddr2l
uniprot id: Q0P4R9
names: Subcellular Location Annotation
messages: Membrane

8364:nkx6-2
gene id: 8364:nkx6-2
uniprot id: F6YSZ3
names: Subcellular Location Annotation
messages: Nucleus

8364:med19
gene id: 8364:med19
uniprot id: A0A8J1JVJ3
uniprot id: B1H175
uniprot id: Q07FY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8364:galnt18
gene id: 8364:galnt18
uniprot id: A0A803K7Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8364:LOC100493555
gene id: 8364:LOC100493555
uniprot id: A0A8J1JLS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

8364:glra2
gene id: 8364:glra2
uniprot id: A0A6I8QKH2
uniprot id: A0A6I8SD41
uniprot id: A0A7D9NLC5
uniprot id: A0A8J0QRH8
uniprot id: A0A8J1J763
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

8364:LOC100492758
gene id: 8364:LOC100492758
uniprot id: A0A6I8R3A6
names: Function
names: Similarity
messages: Belongs to the THADA family.
messages: Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs.

8364:etv3l
gene id: 8364:etv3l
uniprot id: A0A6I8PT21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8364:slc25a22l
gene id: 8364:slc25a22l
uniprot id: A0A8J0SGY9
uniprot id: Q6GLI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8364:kdelr3
gene id: 8364:kdelr3
uniprot id: Q66JF2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: Binds the C-terminal sequence motif K-D-E-L in a hydrophilic cavity between the transmembrane domains. This triggers a conformation change that exposes a Lys-rich patch on the cytosolic surface of the protein (By similarity). This patch mediates recycling from the Golgi to the endoplasmic reticulum, probably via COPI vesicles (By similarity).
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.

8364:LOC116408629
gene id: 8364:LOC116408629
uniprot id: A0A8J1J2Q7
names: Subcellular Location Annotation
messages: Membrane

8364:LOC101731070
gene id: 8364:LOC101731070
uniprot id: A0A6I8SR26
uniprot id: A0A8J1JR02
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:LOC101732098
gene id: 8364:LOC101732098
uniprot id: A0A8J0SX56
names: Subcellular Location Annotation
messages: Nucleus

8364:ptpn18
gene id: 8364:ptpn18
uniprot id: A0A803JDM5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.

8364:bri3
gene id: 8364:bri3
uniprot id: F7DY47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRI3 family.
messages: Membrane
messages: perinuclear region

8364:bhlhe22
gene id: 8364:bhlhe22
uniprot id: Q0V9X5
names: Function
names: Subcellular Location Annotation
messages: May act as a transcriptional repressor.
messages: Nucleus

8364:ngfr
gene id: 8364:ngfr
uniprot id: A0A803JH88
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:cxcr2
gene id: 8364:cxcr2
uniprot id: A0A803JHD4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:dennd6b
gene id: 8364:dennd6b
uniprot id: A0A6I8RAB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND6 family.
messages: Recycling endosome

8364:exoc7
gene id: 8364:exoc7
uniprot id: A0A6I8Q100
uniprot id: A0A6I8RLH7
uniprot id: A0A6I8SPG4
uniprot id: A0A8J1IWJ8
uniprot id: A0A8J1IWK0
uniprot id: A0A8J1IWK4
uniprot id: A0A8J1IWQ5
uniprot id: A0A8J1IZ02
uniprot id: A0A8J1IZ07
uniprot id: A0A8J1IZS3
uniprot id: B1H2K2
names: Function
names: Similarity
messages: Belongs to the EXO70 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

8364:dlx3
gene id: 8364:dlx3
uniprot id: Q5BL47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

8364:tmcc2
gene id: 8364:tmcc2
uniprot id: A0A8J0SP99
uniprot id: A0A8J1J4R2
uniprot id: Q0IHU7
names: Similarity
messages: Belongs to the TEX28 family.

8364:scarb1
gene id: 8364:scarb1
uniprot id: A0A803JWS2
uniprot id: F6U1H4
names: Similarity
messages: Belongs to the CD36 family.

8364:lrrfip2
gene id: 8364:lrrfip2
uniprot id: A0A6I8QFV4
uniprot id: A0A6I8QTC2
uniprot id: A0A6I8T0V3
uniprot id: A0A8J0SFM5
uniprot id: A0A8J0SML7
uniprot id: A0A8J0SP45
uniprot id: A0A8J0SP49
uniprot id: A0A8J0SQ94
uniprot id: A0A8J0SQE4
uniprot id: A0A8J0T3U2
uniprot id: A0A8J1JMI8
uniprot id: A0A8J1JPZ0
uniprot id: A0A8J1JR84
uniprot id: B2GUE2
names: Function
names: Similarity
messages: Belongs to the LRRFIP family.
messages: May function as an activator of the canonical Wnt signaling pathway upstream of ctnnb1/beta-catenin. May be required for dorsal axis formation (By similarity).

8364:nts
gene id: 8364:nts
uniprot id: A0A6I8QBR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurotensin family.
messages: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
messages: Secreted
messages: Vesicle
messages: secretory vesicle

8364:kcnj8
gene id: 8364:kcnj8
uniprot id: A4IHW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

8364:LOC100495517
gene id: 8364:LOC100495517
uniprot id: A0A8J0QNE9
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:mat1a
gene id: 8364:mat1a
uniprot id: A9JTV0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

8364:arsa.1
gene id: 8364:arsa.1
uniprot id: A0A6I8QNF3
names: Similarity
messages: Belongs to the sulfatase family.

8364:lmnb3
gene id: 8364:lmnb3
uniprot id: A0A8J0SIQ6
uniprot id: A4IHY3
names: Similarity
messages: Belongs to the intermediate filament family.

8364:pla1a
gene id: 8364:pla1a
uniprot id: A0A803JSW8
uniprot id: A0A8J1J356
uniprot id: A0A8J1J6K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

8364:LOC100488993
gene id: 8364:LOC100488993
uniprot id: A0A8J0QJN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC101731527
gene id: 8364:LOC101731527
uniprot id: A0A8J1IWQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:lrrc8d
gene id: 8364:lrrc8d
uniprot id: B1H2G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

8364:LOC116406756
gene id: 8364:LOC116406756
uniprot id: A0A059XIA4
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

8364:megf6
gene id: 8364:megf6
uniprot id: A0A6I8Q838
uniprot id: F6UCL2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC116409622
gene id: 8364:LOC116409622
uniprot id: A0A8J1JB07
names: Subcellular Location Annotation
messages: Membrane

8364:vn2r1p
gene id: 8364:vn2r1p
uniprot id: A0A6I8PK71
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:gng10
gene id: 8364:gng10
uniprot id: A0A6I8RCH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8364:ca2
gene id: 8364:ca2
uniprot id: Q5FW20
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

8364:qars1
gene id: 8364:qars1
uniprot id: A0A6I8PWQ6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

8364:dcaf1
gene id: 8364:dcaf1
uniprot id: A0A6I8SPT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPRBP/DCAF1 family.
messages: Nucleus

8364:LOC100489406
gene id: 8364:LOC100489406
uniprot id: A0A6I8PTQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Membrane

8364:sars1
gene id: 8364:sars1
uniprot id: Q6NVT3
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.

8364:slc25a37
gene id: 8364:slc25a37
uniprot id: F7ETQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8364:LOC100494197
gene id: 8364:LOC100494197
uniprot id: A0A8J0SDZ9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC108644798
gene id: 8364:LOC108644798
uniprot id: A0A8J1JQW1
names: Subcellular Location Annotation
messages: Membrane

8364:aldh1l1
gene id: 8364:aldh1l1
uniprot id: A0A8J1JDE6
uniprot id: Q63ZT8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Cytosolic 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide. May also have an NADP(+)-dependent aldehyde dehydrogenase activity towards formaldehyde, acetaldehyde, propionaldehyde, and benzaldehyde (By similarity). Regulates reduced folate pools as well as glycine metabolism (By similarity).
messages: Homotetramer.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.
messages: Phosphopantetheinylation at Ser-354 by AASDHPPT is required for the formyltetrahydrofolate dehydrogenase activity.
messages: The C-terminal aldehyde dehydrogenase domain has an NADP-dependent dehydrogenase activity. It catalyzes the oxidation of formate, released by the hydrolysis of formyltetrahydrofolate, into CO2.
messages: The N-terminal hydrolase domain has an NADP-independent formyltetrahydrofolate hydrolase activity, releasing formate and tetrahydrofolate.
messages: The carrier domain is phosphopantetheinylated and uses the 4'-phosphopantetheine/4'-PP swinging arm to transfer the formyl group released by the N-terminal formyltetrahydrofolate hydrolase activity to the C-terminal aldehyde dehydrogenase domain that catalyzes its NADP-dependent oxidation into CO2. The overall NADP-dependent physiological reaction requires the 3 domains (N-terminal hydrolase, C-terminal aldehyde dehydrogenase and carrier domains) to convert formyltetrahydrofolate into tetrahydrofolate and CO2.
messages: cytosol

8364:LOC101730999
gene id: 8364:LOC101730999
uniprot id: A0A6I8SQD1
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100497655
gene id: 8364:LOC100497655
uniprot id: A0A8J0QQR2
names: Similarity
messages: Belongs to the cyclin family.

8364:slc11a1
gene id: 8364:slc11a1
uniprot id: F7E7W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

8364:kcnq1
gene id: 8364:kcnq1
uniprot id: A0A6I8S7B1
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.1/KCNQ1 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum
messages: Lateral cell membrane
messages: Membrane
messages: Membrane raft

8364:b9d2
gene id: 8364:b9d2
uniprot id: A0A8J0QV68
uniprot id: F7BVU9
names: Subcellular Location Annotation
messages: cilium basal body

8364:mthfs
gene id: 8364:mthfs
uniprot id: B1H138
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

8364:LOC100489207
gene id: 8364:LOC100489207
uniprot id: A0A8J0SUP0
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

8364:ddx52
gene id: 8364:ddx52
uniprot id: B1WAX3
uniprot id: F7BCP5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

8364:ddx43
gene id: 8364:ddx43
uniprot id: Q0P4V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family.
messages: Cytoplasm
messages: Nucleus

8364:reep4
gene id: 8364:reep4
uniprot id: Q5BL63
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DP1 family.
messages: During gastrulation, expressed on the dorsal side of the embryo and then in the neural plate and neural tube. At tailbud stages, expressed in the somites. Expressed in the neural tube later in development.
messages: Endoplasmic reticulum membrane
messages: Inactivation in embryos by antisense morpholino causes paralysis and shortening of the body axis.
messages: Interacts with microtubules.
messages: Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes (By similarity). May play a role in the maintenance of both the nervous system and the musculature.

8364:bivm
gene id: 8364:bivm
uniprot id: Q0V9T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BIVM family.
messages: Cytoplasm
messages: Nucleus

8364:gipr
gene id: 8364:gipr
uniprot id: A0A803JWD0
names: Subcellular Location Annotation
messages: Membrane

8364:acta1
gene id: 8364:acta1
uniprot id: F6UH63
names: Similarity
messages: Belongs to the actin family.

8364:bmp15
gene id: 8364:bmp15
uniprot id: F7A132
names: Similarity
messages: Belongs to the TGF-beta family.

8364:dcstamp
gene id: 8364:dcstamp
uniprot id: A0A8J1JRE1
names: Subcellular Location Annotation
messages: Membrane

8364:bloc1s2
gene id: 8364:bloc1s2
uniprot id: Q66KB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BLOC1S2 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. May also play a role in intracellular vesicle trafficking. As part of a BORC-like complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, this complex may couple lysosomes to microtubule plus-end-directed kinesin motor.
messages: Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1).
messages: Lysosome membrane
messages: centrosome

8364:pald1
gene id: 8364:pald1
uniprot id: Q6DIR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paladin family.
messages: cytosol

8364:tpt1
gene id: 8364:tpt1
uniprot id: A0A6I8QHJ2
uniprot id: Q66JC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTP family.
messages: Cytoplasm
messages: Involved in calcium binding and microtubule stabilization.

8364:gal3st4.6
gene id: 8364:gal3st4.6
uniprot id: B0JZ98
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

8364:abca9
gene id: 8364:abca9
uniprot id: F6PPE6
names: Subcellular Location Annotation
messages: Membrane

8364:mtrf1
gene id: 8364:mtrf1
uniprot id: A0A8J0QUF8
uniprot id: A0A8J0SFN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

8364:LOC101731425
gene id: 8364:LOC101731425
uniprot id: A0A803JIT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-Q/OKP1 family.
messages: Nucleus

8364:dapk2
gene id: 8364:dapk2
uniprot id: A0A6I8SSK8
uniprot id: B0JZ00
uniprot id: F6SJH2
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:dmpk
gene id: 8364:dmpk
uniprot id: A0A6I8R374
uniprot id: A0A803J243
uniprot id: A0A803J4E1
uniprot id: A0A8J1IP85
uniprot id: A0A8J1IP88
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.

8364:psmb11
gene id: 8364:psmb11
uniprot id: A0A8J0QV89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

8364:hnrnpa3
gene id: 8364:hnrnpa3
uniprot id: A0A8J1IRX0
uniprot id: B0BM91
names: Subcellular Location Annotation
messages: Nucleus

8364:clasp1
gene id: 8364:clasp1
uniprot id: A1A5G0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CLASP family.
messages: Interacts (via C-terminus) with clip1/clip-170, and cenpe.
messages: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules during anaphase. Plays a crucial role in chromatin-induced microtubule formation. May also act at microtubule minus ends. May be involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN) (By similarity).
messages: centrosome
messages: cytoskeleton
messages: kinetochore
messages: spindle
messages: trans-Golgi network

8364:pmm1
gene id: 8364:pmm1
uniprot id: A8E4X1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

8364:LOC100489487
gene id: 8364:LOC100489487
uniprot id: A0A8J1IXJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

8364:rbm24
gene id: 8364:rbm24
uniprot id: Q6P8A7
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation. Plays a major role in pre-mRNA alternative splicing regulation. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation. Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing. Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes. Plays a role in the regulation of mRNA stability and mRNA translation to which it is bound. Involved in myogenic differentiation by regulating myog levels. Binds to a huge amount of mRNAs. Required for embryonic heart development, sarcomer and M-band formation in striated muscles.
messages: Nucleus
messages: The RRM domain is necessary for mRNA stability and mRNA translation regulation.

8364:cbl
gene id: 8364:cbl
uniprot id: A0A6I8QR48
uniprot id: B3DLI0
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

8364:LOC116408737
gene id: 8364:LOC116408737
uniprot id: A0A6I8QCA3
names: Similarity
messages: Belongs to the cystatin family.

8364:flvcr2
gene id: 8364:flvcr2
uniprot id: A0A6I8S5F6
uniprot id: A0A8J0SUU5
uniprot id: Q28EC5
names: Subcellular Location Annotation
messages: Membrane

8364:nr2f5
gene id: 8364:nr2f5
uniprot id: A0A8J0R6A9
uniprot id: F7BFY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

8364:marveld3
gene id: 8364:marveld3
uniprot id: A0A6I8Q4V4
uniprot id: A0A8J0SKE5
uniprot id: A0A8J1JG83
uniprot id: Q28F40
names: Subcellular Location Annotation
messages: Membrane

8364:c19orf54
gene id: 8364:c19orf54
uniprot id: A0A8J0SUU3
uniprot id: B0BM95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Actin maturation protease that specifically mediates the cleavage of immature acetylated N-terminal actin, thereby contributing to actin maturation (By similarity). Cleaves N-terminal acetylated methionine of immature cytoplasmic beta- and gamma-actin after translation (By similarity). Cleaves N-terminal acetylated cysteine of muscle alpha-actin after canonical removal of N-terminal methionine (By similarity).
messages: Belongs to the ACTMAP family.
messages: Cytoplasm

8364:ergic3
gene id: 8364:ergic3
uniprot id: A0A8J0T006
uniprot id: A0A8J0T6E6
uniprot id: F6WZZ0
uniprot id: Q6NVS2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a role in transport between endoplasmic reticulum and Golgi.
messages: Possible role in transport between endoplasmic reticulum and Golgi.
messages: cis-Golgi network membrane

8364:LOC108645427
gene id: 8364:LOC108645427
uniprot id: A0A8J1IZN7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:gda
gene id: 8364:gda
uniprot id: A0A6I8SNG6
uniprot id: A0A8J1IMG2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

8364:lpar2
gene id: 8364:lpar2
uniprot id: Q68PF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cell surface
messages: Endosome
messages: Membrane

8364:ptbp1
gene id: 8364:ptbp1
uniprot id: A0A8J0SJN1
uniprot id: Q5XGH0
names: Subcellular Location Annotation
messages: Nucleus

8364:armc8
gene id: 8364:armc8
uniprot id: A0A6I8Q5A2
uniprot id: A0A8J0SVI2
uniprot id: Q5I090
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:LOC100487454
gene id: 8364:LOC100487454
uniprot id: A0A6I8SJC5
names: Similarity
messages: Belongs to the vacuolar ATPase subunit S1 family.

8364:c16orf58
gene id: 8364:c16orf58
uniprot id: F6U0P4
names: Similarity
messages: Belongs to the RUS1 family.

8364:rpl13
gene id: 8364:rpl13
uniprot id: Q6P639
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

8364:fgd1
gene id: 8364:fgd1
uniprot id: A0A6I8SFR7
uniprot id: A0A8J0QW09
uniprot id: A0A8J0SCT5
names: Subcellular Location Annotation
messages: cytoskeleton

8364:tfap2a
gene id: 8364:tfap2a
uniprot id: A0A6I8R1C9
uniprot id: A0A8J0PK44
uniprot id: A0A8J0SFU7
uniprot id: A0A8J0SFV3
uniprot id: A0A8J0SMU6
uniprot id: A0A8J0SQH7
uniprot id: A0A8J0T3G0
uniprot id: A4IHV0
uniprot id: F6RRI4
uniprot id: Q28EF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AP-2 family.
messages: Nucleus

8364:LOC100495652
gene id: 8364:LOC100495652
uniprot id: A0A803JY10
names: Similarity
messages: Belongs to the EVA1 family.

8364:acvr1b
gene id: 8364:acvr1b
uniprot id: F7ESG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

8364:LOC105948306
gene id: 8364:LOC105948306
uniprot id: A0A8J1IR65
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:tgm3l.2
gene id: 8364:tgm3l.2
uniprot id: F6YIE8
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.

8364:dcbld1
gene id: 8364:dcbld1
uniprot id: A0A8J0SDY3
uniprot id: A0A8J1JHZ8
uniprot id: Q6GL27
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:atp6v1c2
gene id: 8364:atp6v1c2
uniprot id: F6YL50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

8364:arhgap33
gene id: 8364:arhgap33
uniprot id: A0A803JZT1
uniprot id: A0A8J1JVD6
uniprot id: A3KN96
uniprot id: F6YQ73
names: Similarity
messages: Belongs to the PX domain-containing GAP family.

8364:slc6a3
gene id: 8364:slc6a3
uniprot id: A0A6I8QNF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.
messages: Cell membrane
messages: Membrane
messages: axon
messages: neuron projection

8364:hspa9
gene id: 8364:hspa9
uniprot id: Q6NVU3
names: Similarity
messages: Belongs to the heat shock protein 70 family.

8364:rgs2
gene id: 8364:rgs2
uniprot id: Q5BKF9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: nucleolus

8364:fzd1
gene id: 8364:fzd1
uniprot id: A0A8J0QGT4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:idh2
gene id: 8364:idh2
uniprot id: Q6GLF0
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

8364:LOC100494680
gene id: 8364:LOC100494680
uniprot id: A0A803K6Z8
uniprot id: A0A803KEQ4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:kcnh3
gene id: 8364:kcnh3
uniprot id: A0A6I8SHB6
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

8364:ero1b
gene id: 8364:ero1b
uniprot id: A0A6I8QIF1
uniprot id: Q0V9Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

8364:nck1
gene id: 8364:nck1
uniprot id: F7BL93
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

8364:clstn2
gene id: 8364:clstn2
uniprot id: F7EF47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsyntenin family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Postsynaptic cell membrane

8364:ppp1r7
gene id: 8364:ppp1r7
uniprot id: Q6DIQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDS22 family.
messages: Nucleus
messages: Regulatory subunit of protein phosphatase 1.

8364:gp25l
gene id: 8364:gp25l
uniprot id: A0A6I8Q2K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:LOC100170611
gene id: 8364:LOC100170611
uniprot id: A0A6I8Q3I4
names: Subcellular Location Annotation
messages: Secreted

8364:cnnm3
gene id: 8364:cnnm3
uniprot id: A0A6I8RUE4
uniprot id: A0A7D9NJL2
uniprot id: A0A8J0SA10
uniprot id: A0A8J0SJ58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Cell membrane
messages: Membrane
messages: Metal transporter.

8364:LOC116410796
gene id: 8364:LOC116410796
uniprot id: A0A8J1JL23
names: Similarity
messages: Belongs to the Izumo family.

8364:tprg1l
gene id: 8364:tprg1l
uniprot id: Q5I023
names: Similarity
messages: Belongs to the TPRG1 family.

8364:rnf168
gene id: 8364:rnf168
uniprot id: A0A8J0SWR7
uniprot id: A0A8J0T2R1
uniprot id: B0BLU1
uniprot id: F7BPQ0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNF168 family.
messages: E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with ube2n/ubc13 to amplify the rnf8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the rnf8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of tp53bp1 and brca1. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).
messages: Monomer.
messages: Nucleus
messages: The MIU motif (motif interacting with ubiquitin) mediates the interaction with both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains. The UMI motif mediates interaction with ubiquitin with a preference for 'Lys-63'-linked ubiquitin. The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs).

8364:LOC116409602
gene id: 8364:LOC116409602
uniprot id: A0A8J1JC15
names: Subcellular Location Annotation
messages: Membrane

8364:top2b
gene id: 8364:top2b
uniprot id: A0A6I8RJA4
uniprot id: F7BGW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
messages: nucleolus
messages: nucleoplasm

8364:LOC116406491
gene id: 8364:LOC116406491
uniprot id: A0A8J1JNS6
names: Subcellular Location Annotation
messages: Membrane

8364:npr2
gene id: 8364:npr2
uniprot id: A0A8J1J2D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

8364:dennd5a
gene id: 8364:dennd5a
uniprot id: A0A6I8RLZ6
uniprot id: A0A6I8S920
uniprot id: B2GUD7
names: Caution
names: Similarity
messages: Belongs to the RAB6IP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:ago3
gene id: 8364:ago3
uniprot id: A0A8J0QNV8
uniprot id: A0A8J0QY72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family. Ago subfamily.
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

8364:LOC100498221
gene id: 8364:LOC100498221
uniprot id: A0A8J0QRD5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8364:LOC100488903
gene id: 8364:LOC100488903
uniprot id: A0A8J0R2W0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:krt20
gene id: 8364:krt20
uniprot id: A0A8J1IXF9
names: Similarity
messages: Belongs to the intermediate filament family.

8364:unc119b
gene id: 8364:unc119b
uniprot id: F6VKI1
names: Similarity
messages: Belongs to the PDE6D/unc-119 family.

8364:lsm1
gene id: 8364:lsm1
uniprot id: Q5PPQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Probably involved with other LSm subunits in the general process of degradation of mRNAs.

8364:LOC100490752
gene id: 8364:LOC100490752
uniprot id: A0A6I8Q093
uniprot id: A0A803JU71
uniprot id: A0A8J0R2C4
uniprot id: A0A8J1JB33
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

8364:plekha8
gene id: 8364:plekha8
uniprot id: A0A803J3V7
uniprot id: F7B5U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLTP family.
messages: trans-Golgi network membrane

8364:pomc
gene id: 8364:pomc
uniprot id: Q5M8F2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POMC family.
messages: Endogenous opiate.
messages: Secreted
messages: Stimulates the adrenal glands to release cortisol.

8364:dcp1b
gene id: 8364:dcp1b
uniprot id: A0A8J0R1F5
uniprot id: A0A8J0R260
uniprot id: F7ADT1
names: Similarity
messages: Belongs to the DCP1 family.

8364:znf830
gene id: 8364:znf830
uniprot id: A0A1B8Y9X4
uniprot id: A0A8J0SPG3
uniprot id: Q6DJ13
names: Function
names: Subcellular Location Annotation
messages: Chromosome
messages: May act as an important regulator of the cell cycle that participates in the maintenance of genome integrity.
messages: Nucleus
messages: Nucleus speckle

8364:LOC116407815
gene id: 8364:LOC116407815
uniprot id: A0A8J1IVT0
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:azin2
gene id: 8364:azin2
uniprot id: A0A8J0PGN1
uniprot id: Q28ED9
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

8364:hnrnpab
gene id: 8364:hnrnpab
uniprot id: F6ZMQ0
uniprot id: Q28BP1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:cyp2u1
gene id: 8364:cyp2u1
uniprot id: A8KBF5
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:rpl31
gene id: 8364:rpl31
uniprot id: Q6DEN9
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.

8364:palm2
gene id: 8364:palm2
uniprot id: A0A8J0QFM5
uniprot id: A0A8J0QHT8
uniprot id: A0A8J1J477
uniprot id: A0A8J1J489
uniprot id: A0A8J1J7N5
uniprot id: F7EIU9
names: Similarity
messages: Belongs to the paralemmin family.

8364:cyp2j2
gene id: 8364:cyp2j2
uniprot id: A0A6I8S9I6
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:LOC100494108
gene id: 8364:LOC100494108
uniprot id: A0A8J1JLH6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

8364:LOC101732806
gene id: 8364:LOC101732806
uniprot id: A0A8J1JX27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

8364:vax2
gene id: 8364:vax2
uniprot id: A0A6I8R1U4
names: Subcellular Location Annotation
messages: Nucleus

8364:cpamd8
gene id: 8364:cpamd8
uniprot id: A0A6I8PW61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8364:stat6
gene id: 8364:stat6
uniprot id: A0A6I8R6D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

8364:mapk8ip1
gene id: 8364:mapk8ip1
uniprot id: A0A7D9N0A1
uniprot id: A0A803KB22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JIP scaffold family.
messages: Cytoplasm

8364:LOC594890
gene id: 8364:LOC594890
uniprot id: F6XWJ4
uniprot id: Q5BL90
names: Similarity
messages: Belongs to the peptidase C1 family.

8364:tert
gene id: 8364:tert
uniprot id: A0A8J0T1U2
uniprot id: A0A8J0T506
uniprot id: A0A8J1JNJ1
uniprot id: F6TTE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reverse transcriptase family. Telomerase subfamily.
messages: Nucleus
messages: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
messages: telomere

8364:accs
gene id: 8364:accs
uniprot id: A0A8J0T066
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:nrm
gene id: 8364:nrm
uniprot id: A0A8J0QVV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane
messages: Nucleus inner membrane

8364:eva1a
gene id: 8364:eva1a
uniprot id: A0A6I8PRK8
uniprot id: A0A6I8QKK2
uniprot id: A0A8J1JHG9
uniprot id: A4IHF0
names: Similarity
messages: Belongs to the EVA1 family.

8364:tmprss11f
gene id: 8364:tmprss11f
uniprot id: A0A8J0QXR3
uniprot id: F6XTL2
names: Subcellular Location Annotation
messages: Membrane

8364:igf2
gene id: 8364:igf2
uniprot id: A0A803K087
uniprot id: A0A8J0SJ94
uniprot id: A9JSC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

8364:aph1a
gene id: 8364:aph1a
uniprot id: A0A803KJM5
uniprot id: Q5EB22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

8364:tff3.4
gene id: 8364:tff3.4
uniprot id: A0A8J0QWZ0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:rock1
gene id: 8364:rock1
uniprot id: A0A6I8SAS2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by RHOA binding. Inhibited by Y-27632.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Homodimer.
messages: Membrane
messages: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.

8364:acad11
gene id: 8364:acad11
uniprot id: A0A6I8SAR5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

8364:tmem231
gene id: 8364:tmem231
uniprot id: A0A8J0SKL1
uniprot id: F7B645
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM231 family.
messages: Membrane
messages: Part of the tectonic-like complex (also named B9 complex).
messages: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).
messages: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
messages: cilium membrane

8364:sctr
gene id: 8364:sctr
uniprot id: A0A8J1IZ30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

8364:znf593
gene id: 8364:znf593
uniprot id: B0BLT0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with pre-60S ribosomal particles.
messages: Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome. Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity.
messages: The protein is largely disordered, with the exception of the zinc finger domain.
messages: nucleolus

8364:ripor1
gene id: 8364:ripor1
uniprot id: A0A6I8QWR6
uniprot id: A0A6I8SV35
uniprot id: A0A8J1JFC5
uniprot id: A0A8J1JIT7
names: Similarity
messages: Belongs to the RIPOR family.

8364:pgam1
gene id: 8364:pgam1
uniprot id: B0BM04
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

8364:btc
gene id: 8364:btc
uniprot id: A0A8J0S681
uniprot id: F7CD16
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:anapc15
gene id: 8364:anapc15
uniprot id: A9JSB3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the APC15 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.
messages: The APC/C is composed of at least 12 subunits.

8364:znf706l
gene id: 8364:znf706l
uniprot id: Q28JA7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:ankrd13c
gene id: 8364:ankrd13c
uniprot id: Q28C34
names: Function
names: Subcellular Location Annotation
messages: Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.
messages: Endoplasmic reticulum membrane

8364:MGC69473
gene id: 8364:MGC69473
uniprot id: Q6NVN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:LOC496913
gene id: 8364:LOC496913
uniprot id: F7ADP0
names: Similarity
messages: Belongs to the peptidase A1 family.

8364:sdhaf4
gene id: 8364:sdhaf4
uniprot id: Q640U1
names: Similarity
messages: Belongs to the SDHAF4 family.

8364:LOC101731658
gene id: 8364:LOC101731658
uniprot id: A0A803JPS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

8364:LOC101733925
gene id: 8364:LOC101733925
uniprot id: A0A803K9E1
names: Subcellular Location Annotation
messages: Membrane

8364:fancm
gene id: 8364:fancm
uniprot id: A0A6I8RK93
uniprot id: A0A8J0R6M3
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.

8364:tmem245
gene id: 8364:tmem245
uniprot id: A0A6I8QCA9
uniprot id: A0A6I8R479
uniprot id: A0A6I8RSF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

8364:rrm2.2
gene id: 8364:rrm2.2
uniprot id: Q68EP1
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

8364:b3galt5l
gene id: 8364:b3galt5l
uniprot id: F7CGG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:cd302
gene id: 8364:cd302
uniprot id: A0A8J1IVW3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:panx3
gene id: 8364:panx3
uniprot id: F7D9M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

8364:psmc5
gene id: 8364:psmc5
uniprot id: Q6P380
names: Similarity
messages: Belongs to the AAA ATPase family.

8364:slc39a11
gene id: 8364:slc39a11
uniprot id: A0A8J0SQX6
uniprot id: A0A8J0SXA6
uniprot id: A0A8J1IYY2
uniprot id: Q28J44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Cell membrane
messages: Cytoplasm
messages: Functions as a cellular zinc transporter.
messages: Golgi apparatus
messages: Membrane
messages: Nucleus

8364:crygdl.15
gene id: 8364:crygdl.15
uniprot id: A0A8J0QQD5
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:amdhd1
gene id: 8364:amdhd1
uniprot id: Q68EP2
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.

8364:LOC101730871
gene id: 8364:LOC101730871
uniprot id: A0A8J1JNP9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:prokr2
gene id: 8364:prokr2
uniprot id: A0A8J0T2Y3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:nell2
gene id: 8364:nell2
uniprot id: A2VCU8
names: Subcellular Location Annotation
messages: Secreted

8364:btaf1
gene id: 8364:btaf1
uniprot id: A0A8J1JWQ9
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100497626
gene id: 8364:LOC100497626
uniprot id: A0A8J0S6R4
names: Subcellular Location Annotation
messages: Membrane

8364:pxylp1
gene id: 8364:pxylp1
uniprot id: Q0IHQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family.
messages: Golgi apparatus membrane
messages: Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains.

8364:LOC100491162
gene id: 8364:LOC100491162
uniprot id: A0A6I8RHE7
names: Similarity
messages: Belongs to the ARTD/PARP family.

8364:rps15a
gene id: 8364:rps15a
uniprot id: A4IH66
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

8364:plppr4
gene id: 8364:plppr4
uniprot id: A0A803J364
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

8364:lyrm2
gene id: 8364:lyrm2
uniprot id: B3DLF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I LYR family.
messages: Involved in effecient integration of the N-module into mitochondrial respiratory chain complex I.
messages: Mitochondrion

8364:caprin2
gene id: 8364:caprin2
uniprot id: F6QR57
names: Similarity
messages: Belongs to the caprin family.

8364:ap2a1
gene id: 8364:ap2a1
uniprot id: A0A8J0SSE6
uniprot id: Q0IHS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes large subunit family.
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.
messages: coated pit

8364:ptpn1
gene id: 8364:ptpn1
uniprot id: B1H2K9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

8364:crisp1.11
gene id: 8364:crisp1.11
uniprot id: A0A8J1JQM4
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:zap70
gene id: 8364:zap70
uniprot id: Q6DF54
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.

8364:hsp90aa1.2
gene id: 8364:hsp90aa1.2
uniprot id: A0JMA1
names: Similarity
messages: Belongs to the heat shock protein 90 family.

8364:hspa8
gene id: 8364:hspa8
uniprot id: A0A6I8RH81
names: Similarity
messages: Belongs to the heat shock protein 70 family.

8364:pde6a
gene id: 8364:pde6a
uniprot id: A0A6I8T213
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8364:rnf40
gene id: 8364:rnf40
uniprot id: A0A6I8RG91
uniprot id: A0A8J0R3D2
uniprot id: A0A8J0R6X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRE1 family.
messages: Nucleus

8364:LOC116411026
gene id: 8364:LOC116411026
uniprot id: A0A8J1JL90
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:rars2
gene id: 8364:rars2
uniprot id: A0A8J0T171
uniprot id: F6QKN3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

8364:c20orf27
gene id: 8364:c20orf27
uniprot id: A0A803JU08
uniprot id: Q68FA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADISSP family.
messages: May be involved in thermogenesis and glucose homeostasis.
messages: Secreted

8364:tyw3
gene id: 8364:tyw3
uniprot id: A0A8J0PHT7
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.

8364:hba3
gene id: 8364:hba3
uniprot id: P08422
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Red blood cells.
messages: This is a larval (tadpole) alpha-globin.

8364:cacng1
gene id: 8364:cacng1
uniprot id: Q5XHK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.
messages: Membrane
messages: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.
messages: sarcolemma

8364:slc50a1
gene id: 8364:slc50a1
uniprot id: Q5EAL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWEET sugar transporter family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Mediates sugar transport across membranes.

8364:phka1
gene id: 8364:phka1
uniprot id: A0A6I8RMF2
uniprot id: A0A8J1IKZ1
uniprot id: B2GUN6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

8364:wnt7a
gene id: 8364:wnt7a
uniprot id: A0A803JYV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8364:casc1
gene id: 8364:casc1
uniprot id: A0A803J618
names: Similarity
messages: Belongs to the DNAI7 family.

8364:epcam
gene id: 8364:epcam
uniprot id: Q5U4Z2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPCAM family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:slc39a6
gene id: 8364:slc39a6
uniprot id: A0A8J0QQS8
names: Subcellular Location Annotation
messages: Membrane

8364:hao2
gene id: 8364:hao2
uniprot id: A0A1B8XVB0
uniprot id: A0A8J0SCW0
uniprot id: Q5BKF6
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

8364:ska3
gene id: 8364:ska3
uniprot id: B0BM16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SKA3 family.
messages: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules.
messages: Component of the SKA1 complex, composed of ska1, ska2 and ska3.
messages: kinetochore
messages: spindle

8364:chst8
gene id: 8364:chst8
uniprot id: A0A6I8SXI5
uniprot id: A0A8J0ST28
uniprot id: Q0D2D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:fgf8
gene id: 8364:fgf8
uniprot id: A0A803KIA6
uniprot id: A0A8J0STN2
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

8364:stx7
gene id: 8364:stx7
uniprot id: A0A6I8PJE3
names: Similarity
messages: Belongs to the syntaxin family.

8364:LOC116412095
gene id: 8364:LOC116412095
uniprot id: A0A8J1JUA6
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:treh
gene id: 8364:treh
uniprot id: A0A6I8S8S0
names: Similarity
messages: Belongs to the glycosyl hydrolase 37 family.

8364:hdac8
gene id: 8364:hdac8
uniprot id: A0A6I8RNR5
uniprot id: A0A8J0SSE5
uniprot id: B1H369
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 1 subfamily.
messages: Binds 1 divalent metal cation per subunit.
messages: Chromosome
messages: Cytoplasm
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of non-histone proteins. In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones.
messages: Its activity is inhibited by trichostatin A (TSA) and butyrate, 2 well known histone deacetylase inhibitors.
messages: Nucleus

8364:smu1
gene id: 8364:smu1
uniprot id: Q6P4J8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SMU1 family.
messages: Component of the spliceosome B complex. Interacts with ik.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Required for normal accumulation of ik (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: The WD repeats assemble into a seven-bladed WD propeller.

8364:dpm3
gene id: 8364:dpm3
uniprot id: Q5XH83
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM3 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.

8364:ptger3
gene id: 8364:ptger3
uniprot id: A0A6I8SKE4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:tmem45a
gene id: 8364:tmem45a
uniprot id: F6ZRP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

8364:ncbp2
gene id: 8364:ncbp2
uniprot id: Q6DES0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NCBP2 family.
messages: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (By simi…
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.
messages: Cytoplasm
messages: Nucleus

8364:mettl16
gene id: 8364:mettl16
uniprot id: B3DL09
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METTL16/RlmF family.
messages: RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure.

8364:chdh
gene id: 8364:chdh
uniprot id: A0A8J1JGX8
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

8364:mtx2
gene id: 8364:mtx2
uniprot id: A0A8J1IUL1
uniprot id: Q6GUH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

8364:tut4
gene id: 8364:tut4
uniprot id: A0A6I8R6N8
uniprot id: A0A8J0R3R6
uniprot id: A0A8J1JG15
uniprot id: A0A8J1JJI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B-like family.
messages: Cytoplasm

8364:cdx2
gene id: 8364:cdx2
uniprot id: Q90X90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

8364:chst9l.1
gene id: 8364:chst9l.1
uniprot id: A0A6I8SLM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:cd99l2
gene id: 8364:cd99l2
uniprot id: A0A8J1IKW0
uniprot id: A0A8J1IKX8
uniprot id: A0A8J1IMW1
uniprot id: B1H3G4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD99 family.
messages: Cell junction
messages: Cell membrane
messages: May function as a homophilic adhesion molecule.

8364:pacsin1
gene id: 8364:pacsin1
uniprot id: A0A6I8QHL6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytosol
messages: ruffle membrane
messages: synaptosome

8364:rad51d
gene id: 8364:rad51d
uniprot id: Q6DJR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Nucleus

8364:irx4
gene id: 8364:irx4
uniprot id: A0A8J0QFZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

8364:slf2
gene id: 8364:slf2
uniprot id: A0A8J0R2Z2
uniprot id: F6ZZK7
names: Similarity
messages: Belongs to the FAM178 family.

8364:il2rg
gene id: 8364:il2rg
uniprot id: A0A6I8PWX8
names: Subcellular Location Annotation
messages: Membrane

8364:ormdl2
gene id: 8364:ormdl2
uniprot id: B7ZT29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

8364:syce1
gene id: 8364:syce1
uniprot id: A0A803JD51
names: Similarity
messages: Belongs to the SYCE family.

8364:rpl35a
gene id: 8364:rpl35a
uniprot id: Q6DDB6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

8364:smim22
gene id: 8364:smim22
uniprot id: A0A8J0SPE8
names: Subcellular Location Annotation
messages: Membrane

8364:eml2
gene id: 8364:eml2
uniprot id: A0A6I8QNQ0
uniprot id: A0A6I8SNH7
uniprot id: A0A8J0QMD2
uniprot id: A0A8J0R630
uniprot id: A0A8J0SU19
uniprot id: A0A8J1IRK8
uniprot id: A0A8J1IRM5
names: Similarity
messages: Belongs to the WD repeat EMAP family.

8364:drd1c
gene id: 8364:drd1c
uniprot id: F6WET9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:rps13
gene id: 8364:rps13
uniprot id: Q28I74
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

8364:nsmce1
gene id: 8364:nsmce1
uniprot id: A0A803J6H7
uniprot id: Q6P881
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE1 family.
messages: Component of the SMC5-SMC6 complex.
messages: Component of the Smc5-Smc6 complex.
messages: Nucleus
messages: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.
messages: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair.
messages: telomere

8364:dtd2
gene id: 8364:dtd2
uniprot id: F6QNU7
names: Similarity
messages: Belongs to the DTD family.

8364:LOC100485969
gene id: 8364:LOC100485969
uniprot id: A0A6I8QBD6
uniprot id: A0A8J1JMS0
uniprot id: A0A8J1JNZ3
uniprot id: F7DES0
names: Subcellular Location Annotation
messages: Membrane

8364:mfn1
gene id: 8364:mfn1
uniprot id: Q28FR9
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

8364:LOC105946381
gene id: 8364:LOC105946381
uniprot id: A0A8J0SXJ8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:or4e2
gene id: 8364:or4e2
uniprot id: A0A8J1IZE3
names: Subcellular Location Annotation
messages: Membrane

8364:cd151
gene id: 8364:cd151
uniprot id: A0A803JZU3
uniprot id: A0A8J1JF90
uniprot id: B1WAT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8364:cd53
gene id: 8364:cd53
uniprot id: F6ZYI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8364:cryab
gene id: 8364:cryab
uniprot id: A0A7D9N0F3
uniprot id: A0A8J1JZR0
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

8364:taf12
gene id: 8364:taf12
uniprot id: B0BLT7
uniprot id: F7CTQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

8364:cops5
gene id: 8364:cops5
uniprot id: Q6P635
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: Component of the CSN complex, probably composed of cops1, cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
messages: Nucleus
messages: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity. In the complex, it probably acts as the catalytic center that mediates the cleavage of nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex.
messages: The CSN complex is associated with some 'Lys-63'-specific deubiquitination. Such activity is however not mediated by the core CSN complex but by the brcc3/brcc36 component of the BRISC complex (By similarity).
messages: The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It constitutes the catalytic center of the complex (By similarity).
messages: cytosol
messages: perinuclear region
messages: synaptic vesicle

8364:mdm4
gene id: 8364:mdm4
uniprot id: A0A803JA46
uniprot id: A0A8J1J183
uniprot id: B5DFR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.
messages: Nucleus

8364:il2rb
gene id: 8364:il2rb
uniprot id: A0A803J3E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Cell membrane
messages: Membrane

8364:mmp17
gene id: 8364:mmp17
uniprot id: A0A803KK53
uniprot id: A4IIY9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

8364:polr2k
gene id: 8364:polr2k
uniprot id: Q28CR4
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

8364:plxnc1
gene id: 8364:plxnc1
uniprot id: A0A8J1JA75
uniprot id: A0A8J1JDQ5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:kcnh8
gene id: 8364:kcnh8
uniprot id: F6W745
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

8364:alg6
gene id: 8364:alg6
uniprot id: Q5I096
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:got2
gene id: 8364:got2
uniprot id: Q28F67
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.
messages: Mitochondrion matrix

8364:zranb2
gene id: 8364:zranb2
uniprot id: A0A8J1JCS6
uniprot id: B4F729
uniprot id: F6R1G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZRANB2 family.
messages: Nucleus

8364:naaladl1
gene id: 8364:naaladl1
uniprot id: A0A8J0SK43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

8364:a2ml1
gene id: 8364:a2ml1
uniprot id: A0A803J8N1
uniprot id: A0A8J1JRV8
uniprot id: A0A8J1JRW1
uniprot id: A0A8J1JRW7
uniprot id: A0A8J1JRX4
uniprot id: A0A8J1JRX8
uniprot id: A0A8J1JUC3
uniprot id: A0A8J1JVN0
uniprot id: A8WGG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8364:gfra3
gene id: 8364:gfra3
uniprot id: F7B6N4
names: Similarity
messages: Belongs to the GDNFR family.

8364:LOC100485437
gene id: 8364:LOC100485437
uniprot id: A0A803J4I7
uniprot id: A0A803K2S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

8364:ppara
gene id: 8364:ppara
uniprot id: F7C0K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

8364:irf1
gene id: 8364:irf1
uniprot id: A0A803KJ15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Nucleus

8364:ndnfl1.1
gene id: 8364:ndnfl1.1
uniprot id: F6UG11
names: Subcellular Location Annotation
messages: Secreted

8364:LOC100498262
gene id: 8364:LOC100498262
uniprot id: A0A8J0SVE0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC105945888
gene id: 8364:LOC105945888
uniprot id: A0A8J0SDJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:ugp2
gene id: 8364:ugp2
uniprot id: A0A8J0SMG3
uniprot id: Q68F95
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

8364:met
gene id: 8364:met
uniprot id: A0A6I8Q702
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

8364:LOC108647647
gene id: 8364:LOC108647647
uniprot id: A0A8J1JMH5
uniprot id: A0A8J1JNQ1
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC100489839
gene id: 8364:LOC100489839
uniprot id: A0A7D9NKW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRRS1 family.
messages: Membrane

8364:LOC101730848
gene id: 8364:LOC101730848
uniprot id: A0A8J0R789
names: Similarity
messages: Belongs to the cyclin family.

8364:qtrt1
gene id: 8364:qtrt1
uniprot id: Q28HC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit qtrt1 and an accessory subunit qtrt2.
messages: Mitochondrion outer membrane

8364:st8sia5
gene id: 8364:st8sia5
uniprot id: A0A6I8S6X4
uniprot id: A0A8J0SCJ0
uniprot id: A2BCP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8364:rnps1
gene id: 8364:rnps1
uniprot id: Q28E41
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the splicing factor SR family.
messages: Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Putative component of the spliceosome which enhances the formation of the ATP-dependent A complex of the spliceosome. May participate in mRNA 3'-end cleavage. Also mediates increase of mRNA abundance and translational efficiency (By similarity).
messages: Component of the active spliceosome.
messages: Cytoplasm
messages: It is uncertain whether Met-1 or Met-26 is the initiator.
messages: Nucleus
messages: Nucleus speckle

8364:nrn1
gene id: 8364:nrn1
uniprot id: B0BMM4
names: Similarity
messages: Belongs to the neuritin family.

8364:usp7
gene id: 8364:usp7
uniprot id: A0A6I8QN49
uniprot id: A0A8J0SW02
names: Similarity
messages: Belongs to the peptidase C19 family.

8364:scarb2
gene id: 8364:scarb2
uniprot id: Q28HW5
names: Similarity
messages: Belongs to the CD36 family.

8364:ehd4
gene id: 8364:ehd4
uniprot id: A0A8J0Q8V4
uniprot id: A4IIT1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

8364:LOC116407775
gene id: 8364:LOC116407775
uniprot id: A0A8J1IVM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC116406499
gene id: 8364:LOC116406499
uniprot id: A0A8J1IPM2
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:xrcc6
gene id: 8364:xrcc6
uniprot id: A0A6I8SU75
uniprot id: F7E5D3
uniprot id: Q6DJB1
names: Subcellular Location Annotation
messages: Nucleus

8364:nat8l
gene id: 8364:nat8l
uniprot id: A4II32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the camello family.
messages: Catalyzes the synthesis of N-acetylaspartate acid (NAA) from L-aspartate and acetyl-CoA.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: Mitochondrion membrane

8364:b3gnt9
gene id: 8364:b3gnt9
uniprot id: A0A6I8RAW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:pgap2
gene id: 8364:pgap2
uniprot id: A0A8J1J3A1
uniprot id: A8KBG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP2 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity).
messages: Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.
messages: Membrane

8364:cgn
gene id: 8364:cgn
uniprot id: B1WB65
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cingulin family.
messages: Deletion of the TJP1/ZO1 interaction motif (ZIM) decreases but does not abolish colocalization with TJP1/ZO1.
messages: It is uncertain whether Met-1 or Met-9 is the initiator.
messages: Parallel homodimer (By similarity). Interacts with TJP1/ZO1 and TJP2/ZO2 (By similarity).
messages: Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier, possibly by linking ZO proteins to the actomyosin cytoskeleton.
messages: tight junction

8364:slc22a5
gene id: 8364:slc22a5
uniprot id: A0A6I8RD12
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Basal cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Interacts with PDZK1.

8364:fam160a1
gene id: 8364:fam160a1
uniprot id: F7DN00
names: Similarity
messages: Belongs to the FHIP family.

8364:kiaa1324
gene id: 8364:kiaa1324
uniprot id: A0A6I8QYI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Membrane

8364:rps18
gene id: 8364:rps18
uniprot id: A9JSA5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Component of the small ribosomal subunit.

8364:cyba
gene id: 8364:cyba
uniprot id: F6ZRG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p22phox family.
messages: Cell membrane
messages: Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).
messages: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
messages: Membrane

8364:LOC116409606
gene id: 8364:LOC116409606
uniprot id: A0A8J1JAZ1
names: Subcellular Location Annotation
messages: Membrane

8364:trex2
gene id: 8364:trex2
uniprot id: A0A6I8S0Y4
names: Similarity
messages: Belongs to the exonuclease superfamily. TREX family.

8364:adrb2
gene id: 8364:adrb2
uniprot id: A0A6I8SU78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane

8364:LOC116409853
gene id: 8364:LOC116409853
uniprot id: A0A8J1JFQ2
names: Similarity
messages: Belongs to the cornifelin family.

8364:usp48
gene id: 8364:usp48
uniprot id: A0A8J1JVQ8
uniprot id: B0JZH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Nucleus

8364:LOC100492062
gene id: 8364:LOC100492062
uniprot id: A0A1B8Y760
uniprot id: A0A8J1IQ32
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:emg1
gene id: 8364:emg1
uniprot id: F7E938
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

8364:LOC100489591
gene id: 8364:LOC100489591
uniprot id: A0A8J0R4G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:esr1
gene id: 8364:esr1
uniprot id: Q6W5G9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

8364:coq5
gene id: 8364:coq5
uniprot id: F6WBE0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

8364:slc18a2
gene id: 8364:slc18a2
uniprot id: A0A803KGP7
names: Subcellular Location Annotation
messages: Membrane

8364:apcs
gene id: 8364:apcs
uniprot id: A0A803K1S4
uniprot id: Q640U5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

8364:tubgcp5
gene id: 8364:tubgcp5
uniprot id: A0A6I8S0M8
uniprot id: A0A8J0R0Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

8364:surf4.1
gene id: 8364:surf4.1
uniprot id: Q28IU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:elk3
gene id: 8364:elk3
uniprot id: A0A6I8Q2M7
uniprot id: Q0IHT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8364:tmem123
gene id: 8364:tmem123
uniprot id: A0A6I8R7K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

8364:exosc9
gene id: 8364:exosc9
uniprot id: B1H0X8
names: Subcellular Location Annotation
messages: Cytoplasm

8364:clca1.2
gene id: 8364:clca1.2
uniprot id: A0A8J0QL21
names: Similarity
messages: Belongs to the CLCR family.

8364:ptpn14
gene id: 8364:ptpn14
uniprot id: F6YAE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

8364:snf8
gene id: 8364:snf8
uniprot id: Q5RJU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF8 family.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II), composed of snf8, vps36 and vps25.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity).
messages: Cytoplasm

8364:uhrf1
gene id: 8364:uhrf1
uniprot id: A0A8J0SPJ8
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.
messages: Nucleus
messages: The YDG domain mediates the interaction with histone H3.
messages: The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3).

8364:LOC116410254
gene id: 8364:LOC116410254
uniprot id: A0A803K900
uniprot id: A0A8J1JEM1
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC116407533
gene id: 8364:LOC116407533
uniprot id: A0A8J1IT64
names: Subcellular Location Annotation
messages: Nucleus

8364:pde6b
gene id: 8364:pde6b
uniprot id: F7AZL7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8364:LOC100492663
gene id: 8364:LOC100492663
uniprot id: A0A8J0QNZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:cbr1.3
gene id: 8364:cbr1.3
uniprot id: B0BMA7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8364:LOC100493823
gene id: 8364:LOC100493823
uniprot id: A0A8J0QSS6
names: Similarity
messages: Belongs to the hexokinase family.

8364:LOC116411013
gene id: 8364:LOC116411013
uniprot id: A0A8J1JL81
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:rsrc2
gene id: 8364:rsrc2
uniprot id: Q5XHJ5
names: Similarity
messages: Belongs to the RSRC2 family.

8364:LOC116406501
gene id: 8364:LOC116406501
uniprot id: A0A8J1JL89
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:dact3
gene id: 8364:dact3
uniprot id: A0A6I8RN91
uniprot id: A0A8J0QJA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Belongs to the dapper family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8364:LOC100497169
gene id: 8364:LOC100497169
uniprot id: A0A803J724
names: Similarity
messages: Belongs to the cyclin family.

8364:or52l1l100488220
gene id: 8364:or52l1l100488220
uniprot id: A0A1B8Y4M9
names: Subcellular Location Annotation
messages: Membrane

8364:mettl21a
gene id: 8364:mettl21a
uniprot id: A4IGU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. METTL21 family.
messages: Cytoplasm
messages: Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members.

8364:ddx20
gene id: 8364:ddx20
uniprot id: A0A8J0QLB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family.
messages: Cytoplasm
messages: Nucleus

8364:LOC100497166
gene id: 8364:LOC100497166
uniprot id: A0A8J1IS97
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC100491871
gene id: 8364:LOC100491871
uniprot id: A0A8J1JJI2
names: Subcellular Location Annotation
messages: Nucleus

8364:vill
gene id: 8364:vill
uniprot id: Q6GL36
names: Similarity
messages: Belongs to the villin/gelsolin family.

8364:ca9
gene id: 8364:ca9
uniprot id: A0A803JZ88
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

8364:LOC116408727
gene id: 8364:LOC116408727
uniprot id: A0A8J1J331
names: Subcellular Location Annotation
messages: Membrane
messages: Secreted

8364:soat2
gene id: 8364:soat2
uniprot id: A0A8J0T0N7
uniprot id: A0A8J1J187
uniprot id: A0A8J1J4N4
uniprot id: B5DFR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:LOC100490677
gene id: 8364:LOC100490677
uniprot id: A0A8J1J8G3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:f2rl3
gene id: 8364:f2rl3
uniprot id: F6WHY7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:ugt1a1
gene id: 8364:ugt1a1
uniprot id: A0A6I8PYU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

8364:LOC100493100
gene id: 8364:LOC100493100
uniprot id: A0A1B8XZW2
uniprot id: Q28D37
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by rag1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:gbp2
gene id: 8364:gbp2
uniprot id: Q0IJ14
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8364:sgsm2
gene id: 8364:sgsm2
uniprot id: A0A6I8SUW2
uniprot id: A0A8J1J6H5
names: Similarity
messages: Belongs to the RUTBC family.

8364:LOC105945923
gene id: 8364:LOC105945923
uniprot id: A0A8J1JX19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8364:npepps
gene id: 8364:npepps
uniprot id: Q08CZ2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

8364:ocstamp
gene id: 8364:ocstamp
uniprot id: A0A8J1IWT6
names: Subcellular Location Annotation
messages: Membrane

8364:vamp3
gene id: 8364:vamp3
uniprot id: Q28E65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

8364:nfkb1
gene id: 8364:nfkb1
uniprot id: A0A8J0S6H7
uniprot id: A0A8J1JM79
uniprot id: F6T195
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:ptprk
gene id: 8364:ptprk
uniprot id: A0A6I8R058
uniprot id: A0A6I8SNL7
uniprot id: A0A6I8SS26
uniprot id: A0A8J0QWW5
uniprot id: A0A8J0T332
uniprot id: A0A8J1JJX2
uniprot id: A0A8J1JJX5
uniprot id: A0A8J1JJX6
uniprot id: A0A8J1JJY1
uniprot id: A0A8J1JJY2
uniprot id: A0A8J1JJY4
uniprot id: A0A8J1JJY5
uniprot id: A0A8J1JJY6
uniprot id: A0A8J1JJY9
uniprot id: A0A8J1JMB9
uniprot id: A0A8J1JMC8
uniprot id: A0A8J1JMD3
uniprot id: A0A8J1JNJ5
uniprot id: A0A8J1JNK0
uniprot id: A0A8J1JNK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

8364:prkcz
gene id: 8364:prkcz
uniprot id: A0A8J0SHK1
uniprot id: A0A8J0SPK0
uniprot id: A0A8J0SSF1
uniprot id: A4IHA4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

8364:dpep2
gene id: 8364:dpep2
uniprot id: A0A803JL05
uniprot id: A0A8J1JFE3
uniprot id: F7EAM4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Homodimer; disulfide-linked.
messages: Membrane

8364:wdr26
gene id: 8364:wdr26
uniprot id: Q28D01
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms homooligomers. Identified in the CTLH complex that contains at least MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10. Interacts with DDB1-CUL4A/B E3 ligase complexes.
messages: G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Core component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (By similarity). Protects also cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity).
messages: Mitochondrion
messages: Nucleus

8364:timp3
gene id: 8364:timp3
uniprot id: A0A803JQP9
names: Similarity
messages: Belongs to the protease inhibitor I35 (TIMP) family.

8364:or6t1
gene id: 8364:or6t1
uniprot id: A0A8J0QLD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:tsr3
gene id: 8364:tsr3
uniprot id: A0A8J0PJ71
uniprot id: A0A8J1IVN2
uniprot id: F6YBY2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:tnnt2
gene id: 8364:tnnt2
uniprot id: A0A8J0QLH7
uniprot id: A0A8J0R879
uniprot id: A0A8J0R8J1
uniprot id: A0A8J1J7P5
uniprot id: F7EHG0
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

8364:slc46a1
gene id: 8364:slc46a1
uniprot id: B1WBG0
names: Subcellular Location Annotation
messages: Membrane

8364:gli2
gene id: 8364:gli2
uniprot id: A0A6I8RCT3
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

8364:spdef
gene id: 8364:spdef
uniprot id: A0A8J0SQG5
uniprot id: A0A8J0SRQ4
uniprot id: A0A8J1J5Q2
uniprot id: Q0V9C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8364:asxl3
gene id: 8364:asxl3
uniprot id: A0A8J0R598
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Asx family.
messages: Nucleus

8364:grm5
gene id: 8364:grm5
uniprot id: A0A6I8Q821
uniprot id: A0A8J0SFY9
uniprot id: A0A8J0SH55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

8364:cdt1
gene id: 8364:cdt1
uniprot id: F6SP82
names: Similarity
messages: Belongs to the Cdt1 family.

8364:sema4a
gene id: 8364:sema4a
uniprot id: A0A8J1JXX3
uniprot id: A9JRL7
uniprot id: F6V936
names: Similarity
messages: Belongs to the semaphorin family.

8364:stk38
gene id: 8364:stk38
uniprot id: A0A6I8S314
uniprot id: F6V346
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC100497305
gene id: 8364:LOC100497305
uniprot id: A0A803K0G7
uniprot id: A0A8J1JML0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC100497614
gene id: 8364:LOC100497614
uniprot id: A0A6I8SFV2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:LOC116410982
gene id: 8364:LOC116410982
uniprot id: A0A803J811
names: Subcellular Location Annotation
messages: Cytoplasmic ribonucleoprotein granule

8364:ift57
gene id: 8364:ift57
uniprot id: B7ZSZ1
uniprot id: Q28HX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT57 family.
messages: Required for the formation of cilia. May also have pro-apoptotic function (By similarity).
messages: cilium basal body

8364:ube2r2
gene id: 8364:ube2r2
uniprot id: Q08CX4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8364:pthlh
gene id: 8364:pthlh
uniprot id: F6WB14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parathyroid hormone family.
messages: Secreted

8364:stc1
gene id: 8364:stc1
uniprot id: A0A8J0R1V5
uniprot id: F7EU28
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

8364:gpha2
gene id: 8364:gpha2
uniprot id: A0A6I8QD90
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer of an alpha and a beta chain.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:dynlrb2
gene id: 8364:dynlrb2
uniprot id: A0A8J1JFZ6
uniprot id: Q28GY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: cytoskeleton

8364:tmc4
gene id: 8364:tmc4
uniprot id: A0A6I8RKK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

8364:pdgfrb
gene id: 8364:pdgfrb
uniprot id: A0A6I8SLH0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC101730890
gene id: 8364:LOC101730890
uniprot id: A0A8J0R499
names: Subcellular Location Annotation
messages: Membrane

8364:LOC116407540
gene id: 8364:LOC116407540
uniprot id: A0A6I8PJF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:crp
gene id: 8364:crp
uniprot id: Q6DIV9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:tm2d2
gene id: 8364:tm2d2
uniprot id: Q5M8E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM2 family.
messages: Membrane

8364:wasf3
gene id: 8364:wasf3
uniprot id: Q0VA47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

8364:bicc1
gene id: 8364:bicc1
uniprot id: A0A8J1JVM3
uniprot id: F7CAX7
names: Similarity
messages: Belongs to the BicC family.

8364:rad18
gene id: 8364:rad18
uniprot id: A0A803K3L3
uniprot id: A0A803K4B5
uniprot id: A0A8J1JGM4
uniprot id: F6YP99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD18 family.
messages: Nucleus

8364:xkr8
gene id: 8364:xkr8
uniprot id: A0A6I8PSE6
uniprot id: Q49M63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

8364:ccdc22
gene id: 8364:ccdc22
uniprot id: A0A6I8RA32
uniprot id: Q28G12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC22 family.
messages: Endosome
messages: May be involved in regulation of NF-kappa-B signaling. May be involved in copper-dependent atp7a trafficking between the trans-Golgi network and vesicles in the cell periphery (By similarity).
messages: centrosome

8364:LOC101732684
gene id: 8364:LOC101732684
uniprot id: A0A8J1J9K3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:olfml2a
gene id: 8364:olfml2a
uniprot id: A4IIT5
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer.
messages: Secreted

8364:iqsec2
gene id: 8364:iqsec2
uniprot id: A0A8J0QSN9
uniprot id: A0A8J0R1S4
uniprot id: A0A8J0R3Q9
uniprot id: A0A8J0R662
uniprot id: A0A8J0R6L6
names: Similarity
messages: Belongs to the BRAG family.

8364:abcc9
gene id: 8364:abcc9
uniprot id: A0A6I8RAA7
uniprot id: A0A6I8RK54
uniprot id: A0A8J1J8U8
uniprot id: A0A8J1J8V0
uniprot id: A0A8J1J8V4
uniprot id: A0A8J1JBA1
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with KCNJ11.
messages: Membrane

8364:lamtor5
gene id: 8364:lamtor5
uniprot id: A0A6I8R091
uniprot id: A9UL91
uniprot id: B7ZTQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.
messages: Belongs to the LAMTOR5 family.
messages: Cytoplasm
messages: Lysosome
messages: Part of the Ragulator complex composed of lamtor1, lamtor2, lamtor3, lamtor4 and lamtor5. The Ragulator complex interacts with slc38a9; the probable amino acid sensor. Component of the lysosomal folliculin complex (LFC).

8364:glce
gene id: 8364:glce
uniprot id: A0A8J0QLI9
names: Similarity
messages: Belongs to the D-glucuronyl C5-epimerase family.

8364:sult6b1.6
gene id: 8364:sult6b1.6
uniprot id: B4F703
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8364:LOC100491497
gene id: 8364:LOC100491497
uniprot id: A0A8J1ISY8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:akt1
gene id: 8364:akt1
uniprot id: A0A6I8Q9M6
uniprot id: A0A6I8SP69
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

8364:pkhd1l1.1
gene id: 8364:pkhd1l1.1
uniprot id: A0A8J1JQ23
names: Subcellular Location Annotation
messages: Nucleus

8364:hbp1
gene id: 8364:hbp1
uniprot id: A0A8J0S9C4
uniprot id: A0A8J0SFB9
uniprot id: F7EI74
uniprot id: F7EI78
uniprot id: Q642N2
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.

8364:upk1b
gene id: 8364:upk1b
uniprot id: Q28G31
names: Subcellular Location Annotation
messages: Membrane

8364:duoxa1
gene id: 8364:duoxa1
uniprot id: A0A8J1JA83
uniprot id: Q0P4G7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane
messages: Possible role in maturation and transport from the endoplasmic reticulum to the plasma membrane of functional dual oxidase.

8364:LOC100492744
gene id: 8364:LOC100492744
uniprot id: A0A803K8J7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Membrane

8364:dnase1
gene id: 8364:dnase1
uniprot id: A0A803JID4
uniprot id: F6W656
names: Similarity
messages: Belongs to the DNase I family.

8364:krt50
gene id: 8364:krt50
uniprot id: A0A8J1IX61
names: Similarity
messages: Belongs to the intermediate filament family.

8364:rnf111
gene id: 8364:rnf111
uniprot id: A0A6I8PTY2
uniprot id: A0A6I8QUU3
uniprot id: A0A6I8S7Z8
uniprot id: A0A8J0SNP5
uniprot id: A0A8J0SXM0
uniprot id: Q0V9R0
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Arkadia family.
messages: Binds free ubiquitin non-covalently via its RING-type zinc finger. Ubiquitin-binding leads to enhance the E3 ubiquitin-protein ligase activity by stabilizing the ubiquitin-conjugating enzyme E2 (donor ubiquitin) in the 'closed' conformation and activating ubiquitin transfer.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the smad2/smad3 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as smad7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP. Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (By similarity). The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity).
messages: Monomer.
messages: Nucleus
messages: PML body
messages: The RING-type zinc finger mediates the E3 ubiquitin-protein ligase activity and binds directly to free ubiquitin (By similarity). Non-covalent ubiquitin-binding stabilizes the ubiquitin-conjugating enzyme E2 (donor ubiquitin) in the 'closed' conformation and stimulates ubiquitin transfer (By similarity).
messages: The SUMO interaction motifs (SIMs) mediates the binding to polysumoylated substrate.

8364:fxn
gene id: 8364:fxn
uniprot id: A0A6I8R145
uniprot id: A0A803J996
uniprot id: A0A8J0SQ65
uniprot id: A0A8J0SZP9
names: Similarity
messages: Belongs to the frataxin family.

8364:rgd1566381
gene id: 8364:rgd1566381
uniprot id: A0A8J1IT25
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:pde1a
gene id: 8364:pde1a
uniprot id: A0A8J1IRU8
uniprot id: A4IIT4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8364:galnt9
gene id: 8364:galnt9
uniprot id: A0A6I8QY28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8364:pcmt1
gene id: 8364:pcmt1
uniprot id: A0A8J0SNY7
uniprot id: A0A8J1JIA7
uniprot id: A0A8J1JIA8
uniprot id: Q5BKH1
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

8364:stpg4
gene id: 8364:stpg4
uniprot id: A0A8J0QLX5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:timp2
gene id: 8364:timp2
uniprot id: F6VSG7
names: Similarity
messages: Belongs to the protease inhibitor I35 (TIMP) family.

8364:LOC116409594
gene id: 8364:LOC116409594
uniprot id: A0A8J1J8J5
names: Subcellular Location Annotation
messages: Membrane

8364:anxa10
gene id: 8364:anxa10
uniprot id: A4QNM7
names: Similarity
messages: Belongs to the annexin family.

8364:ackr4
gene id: 8364:ackr4
uniprot id: F7EFK6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:polr3f
gene id: 8364:polr3f
uniprot id: F7BLB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

8364:fam214a
gene id: 8364:fam214a
uniprot id: A0A8J0SIC1
uniprot id: Q5FW46
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATOS family.
messages: Nucleus
messages: The protein contains 2 transactivation domains (TAD). Each of these domains may be required for transcriptional activation of a subset of target genes.
messages: Transcription regulator that syncronizes transcriptional and translational programs to promote macrophage invasion of tissues.

8364:irf3
gene id: 8364:irf3
uniprot id: A0A8J1JZH5
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC116407573
gene id: 8364:LOC116407573
uniprot id: A0A8J1IW10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:LOC100127750
gene id: 8364:LOC100127750
uniprot id: A0A8J0SUS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

8364:cenpv
gene id: 8364:cenpv
uniprot id: A0A8J0SDC2
uniprot id: A4IGK7
names: Similarity
messages: Belongs to the Gfa family.

8364:dag1
gene id: 8364:dag1
uniprot id: B7ZTF0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.
messages: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
messages: cytoskeleton
messages: extracellular space
messages: nucleoplasm
messages: sarcolemma

8364:skap1
gene id: 8364:skap1
uniprot id: A0A6I8Q1L1
uniprot id: Q6DII7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SKAP family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Phosphorylated on tyrosines.
messages: Positively regulates T-cell receptor signaling. Required for optimal conjugation between T-cells and antigen-presenting cells (By similarity).

8364:nsmce4a
gene id: 8364:nsmce4a
uniprot id: F6YGC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE4 family.
messages: Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
messages: Component of the SMC5-SMC6 complex.
messages: Nucleus
messages: telomere

8364:gpr161
gene id: 8364:gpr161
uniprot id: A0A8J1J4L7
uniprot id: B3DM66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Key negative regulator of Shh signaling during neural tube development. Recruited to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of gli3 into gli3r and repress the Shh signaling. In presence of shh, it is removed from primary cilia, preventing its activity and allowing activation of the Shh signaling (By similarity).
messages: cilium membrane

8364:dnah6
gene id: 8364:dnah6
uniprot id: A0A6I8R5N1
uniprot id: A0A6I8RDK7
uniprot id: A0A8J1JN16
names: Similarity
messages: Belongs to the dynein heavy chain family.

8364:LOC100490910
gene id: 8364:LOC100490910
uniprot id: A0A8J1J3F5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC108646250
gene id: 8364:LOC108646250
uniprot id: A0A8J1JE98
names: Subcellular Location Annotation
messages: Secreted

8364:LOC100493498
gene id: 8364:LOC100493498
uniprot id: A0A8J0QQY0
names: Subcellular Location Annotation
messages: Membrane

8364:eef1a1o
gene id: 8364:eef1a1o
uniprot id: Q6P356
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

8364:LOC100495879
gene id: 8364:LOC100495879
uniprot id: A0A803KB26
uniprot id: A0A8J0QVN0
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

8364:LOC116406901
gene id: 8364:LOC116406901
uniprot id: A0A8J1ISW6
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:slc25a39
gene id: 8364:slc25a39
uniprot id: A0A6I8SVT7
uniprot id: A0A8J0SZH5
uniprot id: A0A8J0T069
uniprot id: A4IIA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8364:LOC100489056
gene id: 8364:LOC100489056
uniprot id: F7CHJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

8364:LOC100498621
gene id: 8364:LOC100498621
uniprot id: A0A6I8SIC9
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:ftmt
gene id: 8364:ftmt
uniprot id: F6WCC8
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

8364:nbl1
gene id: 8364:nbl1
uniprot id: Q6DF53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAN family.
messages: Interacts with bmp2; the interaction is blocked in presence of nog.
messages: May act as a tumor suppressor. Cytokine that has an axial patterning activity. Acts like bone morpho-genetic protein (BMP) antagonist in embryonic explants. Blocks the bmp2 activity (By similarity).
messages: Secreted

8364:ankrd34a
gene id: 8364:ankrd34a
uniprot id: F7BFH4
names: Similarity
messages: Belongs to the ANKRD34 family.

8364:pi4ka
gene id: 8364:pi4ka
uniprot id: A0A8J0QGF5
uniprot id: A0A8J1JXI5
uniprot id: A0A8J1JYW7
uniprot id: A8WGI6
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

8364:comt.2
gene id: 8364:comt.2
uniprot id: Q28HI0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.

8364:lgr5
gene id: 8364:lgr5
uniprot id: F7D3V9
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Maternally and zygotically expressed. Zygotic expression increases after gastrula stage. Expressed predominantly in the endoderm.
messages: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
messages: trans-Golgi network membrane

8364:LOC101734133
gene id: 8364:LOC101734133
uniprot id: W0RZF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:fam149b1
gene id: 8364:fam149b1
uniprot id: A0A6I8PR43
names: Similarity
messages: Belongs to the FAM149 family.

8364:borcs8
gene id: 8364:borcs8
uniprot id: A0A6I8R016
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS8 family.
messages: Lysosome membrane
messages: Membrane

8364:sesn2
gene id: 8364:sesn2
uniprot id: A0A8J1J4K5
uniprot id: Q0V9Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

8364:ap1s1
gene id: 8364:ap1s1
uniprot id: A0A6I8RBY5
uniprot id: Q6P2W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

8364:esr2
gene id: 8364:esr2
uniprot id: Q25C13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

8364:LOC100491854
gene id: 8364:LOC100491854
uniprot id: A0A8J0SK12
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:s1pr4
gene id: 8364:s1pr4
uniprot id: A0A803J812
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:il18
gene id: 8364:il18
uniprot id: A0A8J1JX39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

8364:cdc42ep4
gene id: 8364:cdc42ep4
uniprot id: Q28IQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

8364:kcnj16
gene id: 8364:kcnj16
uniprot id: A0A803K6V5
uniprot id: B1WAZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

8364:mrpl41
gene id: 8364:mrpl41
uniprot id: A9ULK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Mitochondrion

8364:mgrn1
gene id: 8364:mgrn1
uniprot id: A0A8J0PJ16
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin ligase.

8364:lsm14b
gene id: 8364:lsm14b
uniprot id: A0A6I8SMH2
uniprot id: Q566L7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LSM14 family.
messages: Component of a ribonucleoprotein (RNP) complex, at least composed of cpeb1, lsm14b/rap55b, ddx6/Xp54, ybx2/frgy2, pat1/P100, eif4enif1/4E-T and eif4e1b. Different translationally-repressed mRNP complexes probably exist that contain either lsm14a/rap55a or lsm14b/rap55b depending on the developmental stage. Component of a ribonucleoprotein (RNP) complex, composed at least of elavl1/elrA and/or elavl2/elrB, igf2bp3/vg1RBP, ddx6/Xp54, ybx2/frgy2, lsm14b/rap55b and, in a subset of RNP complexes, stau1/staufen (By similarity).
messages: May be involved in the storage of translationally inactive mRNAs and protect them from degradation (By similarity). Plays a role in control of mRNA translation (By similarity).

8364:atp6v1g1
gene id: 8364:atp6v1g1
uniprot id: Q6DFN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

8364:hoxc9
gene id: 8364:hoxc9
uniprot id: Q28J56
names: Subcellular Location Annotation
messages: Nucleus

8364:acad8
gene id: 8364:acad8
uniprot id: A0A6I8QIR4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

8364:nr4a3
gene id: 8364:nr4a3
uniprot id: A0A8J1JTY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

8364:LOC116408373
gene id: 8364:LOC116408373
uniprot id: A0A8J1IZI2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:cuedc2
gene id: 8364:cuedc2
uniprot id: A0A8J1JRZ2
uniprot id: B1H0Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUEDC2 family.
messages: Cytoplasm
messages: Nucleus

8364:tnfrsf21
gene id: 8364:tnfrsf21
uniprot id: F6UZS5
uniprot id: Q0IHT5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:dpy19l1
gene id: 8364:dpy19l1
uniprot id: A0A803JHW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

8364:bms1
gene id: 8364:bms1
uniprot id: A0A8J0QEB6
uniprot id: F6U4Y5
names: Subcellular Location Annotation
messages: nucleolus

8364:LOC108648794
gene id: 8364:LOC108648794
uniprot id: A0A8J0T3R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:cpt2
gene id: 8364:cpt2
uniprot id: Q6P4X5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites. Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters.
messages: Mitochondrion inner membrane

8364:tars1
gene id: 8364:tars1
uniprot id: A0A8J0S602
uniprot id: F6SGS0
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

8364:LOC101733595
gene id: 8364:LOC101733595
uniprot id: A0A8J1JX51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8364:plpp3
gene id: 8364:plpp3
uniprot id: A0A803JLB0
uniprot id: F6R4G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

8364:cnot6l
gene id: 8364:cnot6l
uniprot id: B1H2X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

8364:pigz
gene id: 8364:pigz
uniprot id: A0A8J1JJD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:selenoo
gene id: 8364:selenoo
uniprot id: A0A8J0QEA7
uniprot id: B4F6T8
names: Similarity
messages: Belongs to the SELO family.

8364:ndufaf7
gene id: 8364:ndufaf7
uniprot id: Q5BKM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Acts by mediating symmetric dimethylation of 'Arg-118' of ndufs2 after it assembles into the complex I, stabilizing the early intermediate complex.
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

8364:mmp11
gene id: 8364:mmp11
uniprot id: A0A8J0T0Z7
uniprot id: F6Y400
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

8364:LOC116411722
gene id: 8364:LOC116411722
uniprot id: A0A8J1JR87
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:rax
gene id: 8364:rax
uniprot id: F7CDS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

8364:gdnf
gene id: 8364:gdnf
uniprot id: F6UI64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Homodimer; disulfide-linked.
messages: Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
messages: Secreted

8364:psmf1
gene id: 8364:psmf1
uniprot id: A0A803JKH6
uniprot id: A0A8J1IXU6
names: Similarity
messages: Belongs to the proteasome inhibitor PI31 family.

8364:rad54l2
gene id: 8364:rad54l2
uniprot id: A4IHD2
uniprot id: F7C1Q9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner.
messages: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to be important for the association with nuclear receptors.
messages: Nucleus

8364:cep78
gene id: 8364:cep78
uniprot id: A2RRS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP78 family.
messages: May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles. May play a role in cilium biogenesis.
messages: centriole
messages: centrosome
messages: cilium basal body

8364:afg1l
gene id: 8364:afg1l
uniprot id: A0A6I8PYX8
uniprot id: A0A6I8R4W4
names: Similarity
messages: Belongs to the AFG1 ATPase family.

8364:LOC100496352
gene id: 8364:LOC100496352
uniprot id: A0A803JDH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

8364:cad
gene id: 8364:cad
uniprot id: F7CX88
uniprot id: F7D2L7
names: Similarity
messages: In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.

8364:LOC100496172
gene id: 8364:LOC100496172
uniprot id: A0A8J0QUI4
uniprot id: A0A8J1JEE0
names: Similarity
messages: Belongs to the peptidase C1 family.

8364:ttc9c
gene id: 8364:ttc9c
uniprot id: A4IHU6
names: Similarity
messages: Belongs to the TTC9 family.

8364:LOC100145763
gene id: 8364:LOC100145763
uniprot id: A0A803JB96
names: Similarity
messages: Belongs to the peptidase S28 family.

8364:LOC100492058
gene id: 8364:LOC100492058
uniprot id: A0A6I8T149
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8364:ppp1r10
gene id: 8364:ppp1r10
uniprot id: A0A8J0QVA2
uniprot id: A0A8J0R6D4
names: Subcellular Location Annotation
messages: Nucleus

8364:tcfl5
gene id: 8364:tcfl5
uniprot id: A0A8J1IZU1
names: Subcellular Location Annotation
messages: Nucleus

8364:ranbp9
gene id: 8364:ranbp9
uniprot id: Q28FM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RANBP9/10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Identified in the CTLH complex that contains at least MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10.
messages: May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways. Acts as a mediator of cell spreading and actin cytoskeleton rearrangement. Core component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins.
messages: Nucleus

8364:mtx3
gene id: 8364:mtx3
uniprot id: A0A8J0QWR3
uniprot id: F7EHR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

8364:pdf
gene id: 8364:pdf
uniprot id: Q6DIL5
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins.

8364:atpaf1
gene id: 8364:atpaf1
uniprot id: Q66JD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP11 family.
messages: May play an essential role for the assembly of the mitochondrial F1-F0 complex.
messages: Mitochondrion

8364:slc19a1
gene id: 8364:slc19a1
uniprot id: A0A8J1IUS4
uniprot id: F7EDM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Membrane

8364:mzt2b
gene id: 8364:mzt2b
uniprot id: Q28DB1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MOZART2 family.
messages: Part of the gamma-tubulin complex. Interacts with TUBG1 (By similarity).
messages: centrosome
messages: spindle

8364:trpv5
gene id: 8364:trpv5
uniprot id: A0A8J0QGS4
uniprot id: A0A8J1JS83
uniprot id: A0A8J1JS84
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:psmd4
gene id: 8364:psmd4
uniprot id: A0A8J1IL39
uniprot id: Q6NVQ2
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

8364:enkur
gene id: 8364:enkur
uniprot id: A9UMJ3
names: Subcellular Location Annotation
messages: cilium axoneme

8364:smad6.2
gene id: 8364:smad6.2
uniprot id: A0A1B8XWS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

8364:wnt5b
gene id: 8364:wnt5b
uniprot id: A0A803JA58
uniprot id: Q6DII0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8364:hsf2
gene id: 8364:hsf2
uniprot id: A0A6I8QJX9
uniprot id: A0A8J0QNA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

8364:srek1ip1
gene id: 8364:srek1ip1
uniprot id: Q28EE8
names: Function
messages: Possible splicing regulator involved in the control of cellular survival.

8364:prpsap1
gene id: 8364:prpsap1
uniprot id: A0A6I8Q7W9
uniprot id: A0A8J0SWU1
uniprot id: A0A8J0SZA2
uniprot id: A0A8J1IW97
uniprot id: Q6P8C3
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

8364:lmf1
gene id: 8364:lmf1
uniprot id: A0A6I8RDR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lipase maturation factor family.
messages: Endoplasmic reticulum membrane
messages: Involved in the maturation of specific proteins in the endoplasmic reticulum.
messages: Membrane

8364:pan2
gene id: 8364:pan2
uniprot id: A0A8J0QLM5
names: Activity Regulation
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. PAN2 subfamily.
messages: Binds 2 metal cations per subunit in the catalytic exonuclease domain.
messages: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.
messages: Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.
messages: Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: P-body
messages: Positively regulated by the regulatory subunit PAN3.
messages: The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.

8364:cyp2a6.6
gene id: 8364:cyp2a6.6
uniprot id: A0A8J1IKX9
uniprot id: B2RYY6
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:LOC594879
gene id: 8364:LOC594879
uniprot id: A0A8J0QFY4
uniprot id: Q5BKI3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

8364:vps26c
gene id: 8364:vps26c
uniprot id: A0A803K502
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN).
messages: Belongs to the VPS26 family.
messages: Component of the heterotrimeric retromer cargo-selective complex (CSC) which is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants.
messages: Cytoplasm
messages: Membrane

8364:dgke
gene id: 8364:dgke
uniprot id: A0A6I8R4X4
uniprot id: A0A8J0S5I1
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

8364:sbk3
gene id: 8364:sbk3
uniprot id: A0A8J0QA98
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:gpatch11
gene id: 8364:gpatch11
uniprot id: Q6DF57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPATCH11 family.
messages: kinetochore

8364:popdc2
gene id: 8364:popdc2
uniprot id: A0A1B8Y0F5
uniprot id: A0A8J1J352
names: Similarity
messages: Belongs to the popeye family.

8364:cnga4
gene id: 8364:cnga4
uniprot id: F6VIY1
names: Subcellular Location Annotation
messages: Membrane

8364:LOC101734426
gene id: 8364:LOC101734426
uniprot id: B5DDY3
uniprot id: Q28DR4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by pak2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

8364:alx1
gene id: 8364:alx1
uniprot id: A0A6R5AD90
names: Subcellular Location Annotation
messages: Nucleus

8364:f5
gene id: 8364:f5
uniprot id: A0A6I8R4W9
names: Similarity
messages: Belongs to the multicopper oxidase family.

8364:LOC108648803
gene id: 8364:LOC108648803
uniprot id: A0A8J0SWS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:nbr1
gene id: 8364:nbr1
uniprot id: A0A6I8QTX7
uniprot id: A0A8J1J117
uniprot id: F7CTX3
names: Subcellular Location Annotation
messages: autophagosome

8364:atad1
gene id: 8364:atad1
uniprot id: B4F6J6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. MSP1 subfamily.
messages: Mitochondrion outer membrane
messages: Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (By similarity). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (By similarity).
messages: Peroxisome membrane
messages: Postsynaptic cell membrane

8364:otop1.2
gene id: 8364:otop1.2
uniprot id: A0A6I8STU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

8364:tctex1d1
gene id: 8364:tctex1d1
uniprot id: F7APK8
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

8364:mcts1
gene id: 8364:mcts1
uniprot id: Q6DER1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm
messages: Plays a role as translation enhancer and involved in cell cycle regulation.
messages: The PUA RNA-binding domain is critical for cap binding, but not sufficient for translation enhancer function.

8364:KEG17 p03
gene id: 8364:KEG17_p03
uniprot id: Q5G7I0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 5 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

8364:cln3
gene id: 8364:cln3
uniprot id: A0A8J0QU72
uniprot id: A0A8J0R4E5
uniprot id: A0A8J1IUC1
uniprot id: F7CYW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the battenin family.
messages: Lysosome membrane
messages: Membrane

8364:LOC101731100
gene id: 8364:LOC101731100
uniprot id: A0A8J0SB96
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:slc14a2
gene id: 8364:slc14a2
uniprot id: A0A803J7F5
uniprot id: A0A8J1IYW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

8364:psma1
gene id: 8364:psma1
uniprot id: Q642N1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

8364:orc5
gene id: 8364:orc5
uniprot id: A0A6I8Q5J8
uniprot id: A0A6I8RB65
uniprot id: A0A8J0PIV8
names: Subcellular Location Annotation
messages: Nucleus

8364:mmp9.1
gene id: 8364:mmp9.1
uniprot id: Q6DF16
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: extracellular matrix

8364:dnah10
gene id: 8364:dnah10
uniprot id: A0A6I8R9U4
names: Similarity
messages: Belongs to the dynein heavy chain family.

8364:tfcp2l1
gene id: 8364:tfcp2l1
uniprot id: A0A8J1IXB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

8364:exoc4
gene id: 8364:exoc4
uniprot id: A0A6I8R2Q1
uniprot id: A0A8J0SH06
uniprot id: A0A8J0SZD8
uniprot id: A0A8J0T1B8
uniprot id: A0A8J0T2L6
names: Function
names: Similarity
messages: Belongs to the SEC8 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

8364:smarcb1
gene id: 8364:smarcb1
uniprot id: Q6DFM1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF5 family.
messages: Component of the multiprotein chromatin-remodeling complexes SWI/SNF. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex) (By similarity). Component of the BAF (SWI/SNF) chromatin remodeling complex. Component of the SWI/SNF-B (PBAF) chromatin remodeling complex. Binds to double-stranded DNA (By similarity).
messages: Involved in chromatin-remodeling. Core component of the BAF (SWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex) and may play a role in neural development (By similarity).
messages: Nucleus
messages: The N-terminal DNA-binding region is structurally similar to winged helix domains.

8364:brinp2
gene id: 8364:brinp2
uniprot id: A0A6I8T258
names: Similarity
messages: Belongs to the BRINP family.

8364:LOC100496183
gene id: 8364:LOC100496183
uniprot id: A0A8J0QX63
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FIBIN family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer; disulfide-linked. Seems to also exist as monomers.
messages: Secreted

8364:gng7
gene id: 8364:gng7
uniprot id: Q28H40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8364:LOC116408942
gene id: 8364:LOC116408942
uniprot id: A0A8J1J633
names: Similarity
messages: Belongs to the CD200R family.

8364:pde1b
gene id: 8364:pde1b
uniprot id: A0A6I8R788
uniprot id: A0A8J1J324
uniprot id: A1L1D8
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8364:sycp2l
gene id: 8364:sycp2l
uniprot id: A0A8J0R478
uniprot id: A0A8J0SRY9
uniprot id: A0A8J0T1V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYCP2 family.
messages: Nucleus

8364:rgs9bpl
gene id: 8364:rgs9bpl
uniprot id: Q5M8K0
names: Function
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.
messages: Regulator of G protein-coupled receptor (GPCR) signaling. Probably acts by regulating the activity of some 'R7' family protein (RGS6, RGS7, RGS9 and/or RGS11).

8364:LOC594886
gene id: 8364:LOC594886
uniprot id: A0A8J0QW80
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:rpl8
gene id: 8364:rpl8
uniprot id: Q6PBF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

8364:lrrc8c
gene id: 8364:lrrc8c
uniprot id: A0A6I8PZH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

8364:LOC108646253
gene id: 8364:LOC108646253
uniprot id: A0A8J0T2X7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:slc9a9
gene id: 8364:slc9a9
uniprot id: A0A803JEY2
uniprot id: A0A8J1JML7
uniprot id: F6RC40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Endosome membrane
messages: Recycling endosome membrane

8364:gkap1
gene id: 8364:gkap1
uniprot id: Q5M8L3
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GKAP1 family.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Golgi apparatus
messages: May play a role in the regulation of insulin-dependent IRS1 tyrosine phosphorylation in adipocytes.

8364:nae1
gene id: 8364:nae1
uniprot id: A0A803KLH2
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
messages: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

8364:rasl11b
gene id: 8364:rasl11b
uniprot id: Q5FVY2
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

8364:spata18.2
gene id: 8364:spata18.2
uniprot id: F6VD39
uniprot id: F6YGM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIEAP family.
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion outer membrane

8364:nipsnap3a
gene id: 8364:nipsnap3a
uniprot id: Q6DJ76
names: Similarity
messages: Belongs to the NipSnap family.

8364:npy5r
gene id: 8364:npy5r
uniprot id: F7A901
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.

8364:rundc3a
gene id: 8364:rundc3a
uniprot id: A0A8J0S5C5
uniprot id: Q0V9V7
names: Similarity
messages: Belongs to the RUNDC3 family.

8364:cdx1
gene id: 8364:cdx1
uniprot id: Q90X89
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Expressed around the blastopore through gastrula stages. Expressed in the neural tube (posterior dorsal neuroectoderm and the posterior ventral ectoderm) at late neurula stage 20. Expressed in the posterior tip of the neural tube and the posterior wall of the neuroenteric canal at tail bud stage 30. Expressed in the developing gut at stage 40.
messages: Nucleus
messages: Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1. Binds to the PRKD1 promoter. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA.

8364:mmp23b
gene id: 8364:mmp23b
uniprot id: A0A6I8SRJ3
uniprot id: A0A8J1JZU1
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:uggt1
gene id: 8364:uggt1
uniprot id: A0A6I8S0R8
uniprot id: A0A8J0QRZ4
uniprot id: A0A8J0R4N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

8364:LOC101734349
gene id: 8364:LOC101734349
uniprot id: A0A8J0R249
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:xv2r1
gene id: 8364:xv2r1
uniprot id: A0A8J0SQG7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:zdhhc12
gene id: 8364:zdhhc12
uniprot id: A0A803KCZ2
uniprot id: A0A8J0SY48
uniprot id: Q28DG2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8364:ido1
gene id: 8364:ido1
uniprot id: Q6DFT5
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

8364:clcn6
gene id: 8364:clcn6
uniprot id: A0A6I8RU90
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:mfsd3
gene id: 8364:mfsd3
uniprot id: A4IIA0
names: Subcellular Location Annotation
messages: Membrane

8364:a4galt
gene id: 8364:a4galt
uniprot id: A0A8J0QXX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

8364:mlst8
gene id: 8364:mlst8
uniprot id: G1K3H6
uniprot id: Q5I0B4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LST8 family.
messages: Cytoplasm
messages: Lysosome membrane
messages: Part of TORC1 complex. Part of the TORC2 complex.
messages: Part of the mechanistic target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8 and RPTOR. Part of the mechanistic target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR.
messages: Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals.
messages: Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. In response to nutrients, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy. The mTORC1 complex is inhibited in response to starvation and amino acid depletion. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin.

8364:kcnn3
gene id: 8364:kcnn3
uniprot id: A0A8J1ISI1
names: Subcellular Location Annotation
messages: Membrane

8364:cacng7
gene id: 8364:cacng7
uniprot id: F6TTB9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2.

8364:stmn2
gene id: 8364:stmn2
uniprot id: A0A803JXJ0
uniprot id: Q6DDB7
names: Similarity
messages: Belongs to the stathmin family.

8364:LOC108648819
gene id: 8364:LOC108648819
uniprot id: A0A8J1IT36
names: Similarity
messages: Belongs to the ARTD/PARP family.

8364:mrpl33
gene id: 8364:mrpl33
uniprot id: A0A8J0QUV2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

8364:LOC116406533
gene id: 8364:LOC116406533
uniprot id: A0A803JVY3
names: Similarity
messages: Belongs to the cyclin family.

8364:LOC100487727
gene id: 8364:LOC100487727
uniprot id: A0A8J1JHC3
uniprot id: A0A8J1JIC4
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.

8364:htt
gene id: 8364:htt
uniprot id: A0A6I8RIL2
uniprot id: A0A6R5A4C7
uniprot id: A0A8J1IZY9
uniprot id: A0A8J1J007
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the huntingtin family.
messages: Cytoplasm
messages: May play a role in microtubule-mediated transport or vesicle function.
messages: Nucleus

8364:LOC116408577
gene id: 8364:LOC116408577
uniprot id: A0A8J1J2G2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:jpt2
gene id: 8364:jpt2
uniprot id: A0A6I8PKV3
uniprot id: B4F6I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

8364:csnk1g2
gene id: 8364:csnk1g2
uniprot id: A0A8J0SM70
uniprot id: F6ZCS3
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

8364:LOC101733987
gene id: 8364:LOC101733987
uniprot id: A0A8J0R1Z0
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:myo7b
gene id: 8364:myo7b
uniprot id: A0A6I8QMW0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:ccnyl1
gene id: 8364:ccnyl1
uniprot id: Q28EL0
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

8364:opn7b
gene id: 8364:opn7b
uniprot id: Q0P4J1
names: Subcellular Location Annotation
messages: Membrane

8364:s100a1
gene id: 8364:s100a1
uniprot id: A0A1B8XWG7
names: Similarity
messages: Belongs to the S-100 family.

8364:reln
gene id: 8364:reln
uniprot id: A0A803KLF3
uniprot id: A0A8J0SHW2
uniprot id: A0A8J1J6R1
uniprot id: A0A8J1J957
uniprot id: B5DDZ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the reelin family.
messages: Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Oligomer of disulfide-linked homodimers. Binds to the ectodomains of VLDLR and LRP8/APOER2.
messages: extracellular matrix

8364:kcng4
gene id: 8364:kcng4
uniprot id: F6Y7C6
names: Subcellular Location Annotation
messages: Membrane

8364:sart1
gene id: 8364:sart1
uniprot id: A0A6I8PWL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNU66/SART1 family.
messages: Nucleus

8364:LOC101731462
gene id: 8364:LOC101731462
uniprot id: A0A8J0S6U0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:smoc1
gene id: 8364:smoc1
uniprot id: A0A8J0SKA8
uniprot id: A0A8J0SKB2
uniprot id: A0A8J0SSF7
uniprot id: A0A8J0SSG1
uniprot id: A0A8J0SU36
uniprot id: A0A8J0SUY5
uniprot id: A0A8J0SVH2
uniprot id: B1WB02
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:vegt
gene id: 8364:vegt
uniprot id: Q28HY0
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed both maternally and zygotically.
messages: Forms a repression complex on the promoters of the nodal/nr1 and siamois genes with the maternal factors tcf7l1/tcf3 and pouf5.1/oct-25. Interacts (via C-terminus) with tcf7l1/tcf3 (via N-terminus). Also interacts with the other POU-domain transcription factors pou5f1.2/oct-91 and pou5f1.3/oct-60 (By similarity).
messages: Nucleus
messages: Transcription factor required for both mesoderm and endoderm formation in the embryo; signaling determinants and concentration levels may determine which germ layer is formed. Acts together with beta-catenin to activate genes that are responsible for mesoderm induction including wnt-8, eomes t/bra, siamois, mix1 and sox17. Directly binds to promoter DNA. Patterns the mesoderm along the dorsoventral and posterior axis. Activates siamois gene transcription when alone or in combination with beta-catenin, but inhibits siamois transcription in combination with pou5f1.1/oct-25 (By similarity).
messages: Vegetally localized in oocytes and expressed in the presumptive endoderm and mesoderm at early gastrula stage. Expression is down-regulated in the endoderm by the end of gastrulation but maintained in the lateral and ventral mesoderm of the blastopore lip.

8364:LOC116409655
gene id: 8364:LOC116409655
uniprot id: A0A8J1J8Q5
names: Subcellular Location Annotation
messages: Membrane

8364:dnase1l1
gene id: 8364:dnase1l1
uniprot id: A0A803JPM8
names: Similarity
messages: Belongs to the DNase I family.

8364:pcnx2
gene id: 8364:pcnx2
uniprot id: A0A8J1JMF4
uniprot id: A0A8J1JNN0
uniprot id: F7AD42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

8364:tmem150a
gene id: 8364:tmem150a
uniprot id: Q28BP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRAM/TMEM150 family.
messages: Cell membrane
messages: Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane.

8364:nefl
gene id: 8364:nefl
uniprot id: F6TRE5
names: Similarity
messages: Belongs to the intermediate filament family.

8364:eif3a
gene id: 8364:eif3a
uniprot id: A4II09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit A family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

8364:c8b
gene id: 8364:c8b
uniprot id: F6R5H7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:tuba8
gene id: 8364:tuba8
uniprot id: A4IGR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

8364:bap1
gene id: 8364:bap1
uniprot id: Q66JB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C12 family. BAP1 subfamily.
messages: Component of the PR-DUB complex.
messages: Cytoplasm
messages: Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity).
messages: Nucleus

8364:ilvbl
gene id: 8364:ilvbl
uniprot id: A0A6I8RN08
uniprot id: B0JZX6
names: Similarity
messages: Belongs to the TPP enzyme family.

8364:nat9
gene id: 8364:nat9
uniprot id: A0A6I8QB08
names: Similarity
messages: Belongs to the acetyltransferase family. GNAT subfamily.

8364:vasn
gene id: 8364:vasn
uniprot id: Q6DF55
names: Function
names: Subcellular Location Annotation
messages: May act as an inhibitor of TGF-beta signaling.
messages: Membrane

8364:ippk
gene id: 8364:ippk
uniprot id: A0JM57
names: Domain
names: Function
names: Similarity
messages: Belongs to the IPK1 type 2 family.
messages: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
messages: The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

8364:LOC105946285
gene id: 8364:LOC105946285
uniprot id: A0A8J0S6Q8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC101735291
gene id: 8364:LOC101735291
uniprot id: A0A8J1J820
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:psme2
gene id: 8364:psme2
uniprot id: Q5HZU3
names: Similarity
messages: Belongs to the PA28 family.

8364:adh5
gene id: 8364:adh5
uniprot id: Q5HZT1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

8364:plcb2
gene id: 8364:plcb2
uniprot id: F6VSL4
names: Cofactor
names: Function
messages: Binds 1 Ca(2+) ion per subunit.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

8364:LOC101731097
gene id: 8364:LOC101731097
uniprot id: A0A8J1ISX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:enam
gene id: 8364:enam
uniprot id: B9UIT7
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100495877
gene id: 8364:LOC100495877
uniprot id: A0A8J0QVF5
names: Subcellular Location Annotation
messages: Membrane

8364:ap3b1
gene id: 8364:ap3b1
uniprot id: A0A6I8RTV0
uniprot id: A0A8J0SRM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes large subunit family.
messages: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
messages: clathrin-coated vesicle membrane

8364:LOC100493151
gene id: 8364:LOC100493151
uniprot id: A0A6I8QGF2
names: Similarity
messages: Belongs to the HARBI1 family.

8364:ppp1r14c
gene id: 8364:ppp1r14c
uniprot id: F7BC28
names: Similarity
messages: Belongs to the PP1 inhibitor family.

8364:rps6ka6
gene id: 8364:rps6ka6
uniprot id: A0A6I8QSE5
uniprot id: A0A8J1IU12
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

8364:rrp7a
gene id: 8364:rrp7a
uniprot id: A0A8J0QP48
names: Similarity
messages: Belongs to the RRP7 family.

8364:luc7l2
gene id: 8364:luc7l2
uniprot id: A0A8J0SBN1
uniprot id: A0A8J0SIJ1
uniprot id: A0A8J0SLE3
uniprot id: Q28EN5
uniprot id: Q6NVN5
names: Similarity
messages: Belongs to the Luc7 family.

8364:tifa
gene id: 8364:tifa
uniprot id: B5DE70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter molecule that plays a key role in the activation of pro-inflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs) (By similarity). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism (By similarity).
messages: Belongs to the TIFA family.
messages: Cytoplasm
messages: Interacts with traf6.

8364:vps13d
gene id: 8364:vps13d
uniprot id: A0A6I8QVF3
uniprot id: A0A6I8RAW6
names: Similarity
messages: Belongs to the VPS13 family.

8364:LOC100497748
gene id: 8364:LOC100497748
uniprot id: A0A6I8PZF2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:unc5d
gene id: 8364:unc5d
uniprot id: A0A6I8RDY6
uniprot id: A0A6I8RGJ8
uniprot id: A0A6I8SLZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

8364:znrd1
gene id: 8364:znrd1
uniprot id: A0A6I8RIK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.
messages: nucleolus

8364:ccdc65
gene id: 8364:ccdc65
uniprot id: F6X3T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC1 family.
messages: cilium axoneme
messages: flagellum axoneme

8364:lpar4
gene id: 8364:lpar4
uniprot id: Q0P4I5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:mrps36
gene id: 8364:mrps36
uniprot id: A0A8J0SE45
uniprot id: Q0VFD3
names: Subcellular Location Annotation
messages: Mitochondrion

8364:gas8
gene id: 8364:gas8
uniprot id: A8E5V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC4 family.
messages: flagellum
messages: flagellum axoneme

8364:mrps33
gene id: 8364:mrps33
uniprot id: F6UGP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

8364:coro2a
gene id: 8364:coro2a
uniprot id: A0A6I8RNR9
names: Similarity
messages: Belongs to the WD repeat coronin family.

8364:tctex1d4
gene id: 8364:tctex1d4
uniprot id: A0A803JHX9
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

8364:polr3h
gene id: 8364:polr3h
uniprot id: Q0V9F2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

8364:LOC116412383
gene id: 8364:LOC116412383
uniprot id: A0A8J1JWZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

8364:LOC100492837
gene id: 8364:LOC100492837
uniprot id: A0A8J0QT60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:map7d1
gene id: 8364:map7d1
uniprot id: A0A8J1J4F2
uniprot id: F7CXB2
names: Similarity
messages: Belongs to the MAP7 family.

8364:senp5
gene id: 8364:senp5
uniprot id: A0A6I8PXC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

8364:LOC108644466
gene id: 8364:LOC108644466
uniprot id: A0A8J0QKS4
uniprot id: A0A8J1ILJ2
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:ccn3
gene id: 8364:ccn3
uniprot id: A0A6I8Q5Y4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:sumo1
gene id: 8364:sumo1
uniprot id: Q6DEP7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Cell membrane
messages: Cleavage of precursor form by a sentrin-specific protease is necessary for function.
messages: Cytoplasm
messages: Interacts with sae2, ube2i, ranbp2, pias1 and pias2 (By similarity). Interacts with sox9 and sox10 (By similarity). Covalently attached to a number of proteins (By similarity).
messages: Nucleus
messages: Nucleus membrane
messages: Nucleus speckle
messages: PML body
messages: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer (By similarity). Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric sumo1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity).

8364:tfap2c
gene id: 8364:tfap2c
uniprot id: A0A6I8RB79
uniprot id: A0A8J0SYW6
uniprot id: Q28F74
uniprot id: Q5XGF5
names: Similarity
messages: Belongs to the AP-2 family.

8364:ddr1
gene id: 8364:ddr1
uniprot id: A0A7D9NM97
uniprot id: A0A8J0QR30
names: Subcellular Location Annotation
messages: Membrane

8364:rpl10
gene id: 8364:rpl10
uniprot id: Q6DIQ8
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

8364:LOC116407732
gene id: 8364:LOC116407732
uniprot id: F7D391
names: Caution
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: cilium membrane

8364:LOC116408331
gene id: 8364:LOC116408331
uniprot id: A0A8J1IZF9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:scnn1a
gene id: 8364:scnn1a
uniprot id: F7AE39
uniprot id: Q6P258
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Membrane
messages: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.

8364:hspa1l
gene id: 8364:hspa1l
uniprot id: Q0V9A5
names: Similarity
messages: Belongs to the heat shock protein 70 family.

8364:slc4a10
gene id: 8364:slc4a10
uniprot id: A0A6I8QME2
uniprot id: A0A8J0QN20
uniprot id: A0A8J0SPH0
uniprot id: A0A8J1IUT7
uniprot id: A0A8J1IX69
uniprot id: A0A8J1IXY6
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

8364:LOC100493456
gene id: 8364:LOC100493456
uniprot id: A0A8J0QTL6
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

8364:cnnm1
gene id: 8364:cnnm1
uniprot id: A0A803K0U2
uniprot id: A0A8J1JUT9
uniprot id: A0A8J1JUU3
uniprot id: F6WMC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Cell membrane
messages: Membrane
messages: Metal transporter.

8364:htr7l
gene id: 8364:htr7l
uniprot id: A0A803KBL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:stx11
gene id: 8364:stx11
uniprot id: F6VUS3
names: Similarity
messages: Belongs to the syntaxin family.

8364:sdhc
gene id: 8364:sdhc
uniprot id: A9UM72
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

8364:tmbim1
gene id: 8364:tmbim1
uniprot id: Q569D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

8364:smarcd1
gene id: 8364:smarcd1
uniprot id: Q6GL18
names: Similarity
messages: Belongs to the SMARCD family.

8364:hal.2
gene id: 8364:hal.2
uniprot id: F6RBJ7
uniprot id: Q6DF42
names: Similarity
messages: Belongs to the PAL/histidase family.

8364:LOC116407597
gene id: 8364:LOC116407597
uniprot id: B5DDY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:rpa3
gene id: 8364:rpa3
uniprot id: B2RYX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

8364:sgca
gene id: 8364:sgca
uniprot id: F6X475
names: Function
names: Similarity
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

8364:trit1
gene id: 8364:trit1
uniprot id: A0A8J0T1G7
uniprot id: Q5M8G8
names: Function
names: Similarity
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.

8364:spin1
gene id: 8364:spin1
uniprot id: A9ULI5
names: Similarity
messages: Belongs to the SPIN/STSY family.

8364:LOC116409562
gene id: 8364:LOC116409562
uniprot id: A0A8J1J8B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8364:rtn1
gene id: 8364:rtn1
uniprot id: A7MC64
uniprot id: A8WGE1
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity.
messages: Membrane
messages: Nucleus

8364:zhx2
gene id: 8364:zhx2
uniprot id: B3DLY6
uniprot id: F6UCZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

8364:skp1
gene id: 8364:skp1
uniprot id: Q28CT2
names: Function
names: Similarity
messages: Belongs to the SKP1 family.
messages: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.

8364:grik3
gene id: 8364:grik3
uniprot id: A0A6I8RI88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8364:wdr61
gene id: 8364:wdr61
uniprot id: Q6PBD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SKI8 family.
messages: Component of the PAF1 complex (By similarity). Component of the SKI complex (By similarity).
messages: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. Also acts as a component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways. The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation.
messages: Cytoplasm
messages: Nucleus

8364:plk5
gene id: 8364:plk5
uniprot id: F6VBJ2
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

8364:ntrk2
gene id: 8364:ntrk2
uniprot id: A0A6I8PYZ5
uniprot id: Q08D53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

8364:tbx18
gene id: 8364:tbx18
uniprot id: F6V9T9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8364:LOC116407608
gene id: 8364:LOC116407608
uniprot id: A0A8J1ITU0
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC100485723
gene id: 8364:LOC100485723
uniprot id: A0A8J0QMM3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:celf2
gene id: 8364:celf2
uniprot id: A0A6I8Q7Q5
uniprot id: A0A6I8RSD8
uniprot id: A0A6I8SMK8
uniprot id: A0A8J0S8V8
uniprot id: A0A8J0S8V9
uniprot id: A0A8J0S8W2
uniprot id: A0A8J0S8W5
uniprot id: A0A8J0SEL0
uniprot id: A0A8J0SGB4
uniprot id: A0A8J0SGC1
uniprot id: A0A8J0SGC6
uniprot id: A0A8J0SHG8
uniprot id: A0A8J0SHH3
uniprot id: A0A8J0SHH7
uniprot id: A0A8J0SHH9
uniprot id: A0A8J0SHI1
uniprot id: A0A8J0SHI4
uniprot id: A0A8J0SHI6
uniprot id: A0A8J0SHJ2
uniprot id: A0A8J0T0V3
uniprot id: A0A8J0T245
uniprot id: A0A8J1J6A7
uniprot id: A0A8J1J6B3
uniprot id: A0A8J1J6B4
uniprot id: A0A8J1J6B6
uniprot id: A0A8J1J8Q7
uniprot id: A0A8J1J9S0
uniprot id: A4IIM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus
messages: RNA-binding protein implicated in the regulation of several post-transcriptional events. May be involved in pre-mRNA alternative splicing, mRNA translation repression and stability (By similarity).

8364:timm10b
gene id: 8364:timm10b
uniprot id: A0A803KA21
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

8364:ttc36
gene id: 8364:ttc36
uniprot id: Q5EBF2
names: Similarity
messages: Belongs to the TTC36 family.

8364:pole2
gene id: 8364:pole2
uniprot id: A0A8J0SUY7
uniprot id: Q5BJ62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase epsilon subunit B family.
messages: Nucleus
messages: Participates in DNA repair and in chromosomal DNA replication.

8364:syp
gene id: 8364:syp
uniprot id: F7DFQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

8364:itpr3
gene id: 8364:itpr3
uniprot id: A4ZYX8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Membrane
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

8364:tmed4
gene id: 8364:tmed4
uniprot id: Q5FVX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:alas1
gene id: 8364:alas1
uniprot id: Q66JC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

8364:spaca5
gene id: 8364:spaca5
uniprot id: Q5M8G0
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

8364:nid1
gene id: 8364:nid1
uniprot id: A0A6I8QAC0
uniprot id: F6VE55
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

8364:crisp1.3
gene id: 8364:crisp1.3
uniprot id: Q642T6
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:trabd2b
gene id: 8364:trabd2b
uniprot id: P0DJQ9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIKI family.
messages: Cell membrane
messages: Divalent metal cations. Mn(2+) or Co(2+).
messages: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave wnt8. Required for head formation.
messages: Was named TIKI in reference to large-headed humanoid in Polynesian mythology.

8364:ccdc85b
gene id: 8364:ccdc85b
uniprot id: A0A803JLI3
uniprot id: B1WBE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

8364:tmem87a
gene id: 8364:tmem87a
uniprot id: A0A6I8RL11
uniprot id: A0A8J0QME8
uniprot id: A0A8J0R2I8
uniprot id: F6WEB3
names: Subcellular Location Annotation
messages: Membrane

8364:areg
gene id: 8364:areg
uniprot id: F6VBJ9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:aopep
gene id: 8364:aopep
uniprot id: A0A6I8SC96
uniprot id: A0A8J0SZ72
names: Similarity
messages: Belongs to the peptidase M1 family.

8364:faim2
gene id: 8364:faim2
uniprot id: A0A6I8PX03
uniprot id: A0A803K3I3
uniprot id: A0A803K5A1
uniprot id: Q0V9N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

8364:ano8
gene id: 8364:ano8
uniprot id: A0A6I8PZH1
uniprot id: A0A6I8QME6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:pabpc1
gene id: 8364:pabpc1
uniprot id: Q6DF12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

8364:chmp5
gene id: 8364:chmp5
uniprot id: Q5FW29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Endosome membrane
messages: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity).
messages: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III).
messages: cytosol

8364:fbln5
gene id: 8364:fbln5
uniprot id: Q5BKG6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:gpm6b
gene id: 8364:gpm6b
uniprot id: A0A803KI96
uniprot id: Q0IHP9
uniprot id: Q28GS9
uniprot id: Q6DFR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

8364:ywhah
gene id: 8364:ywhah
uniprot id: Q28DR3
names: Function
names: Similarity
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
messages: Belongs to the 14-3-3 family.

8364:mark2
gene id: 8364:mark2
uniprot id: A0A6I8S8B2
uniprot id: A0A6I8S976
uniprot id: A0A8J0SA76
uniprot id: A0A8J1JDM4
uniprot id: A0A8J1JDM6
uniprot id: A0A8J1JG48
uniprot id: Q5BL77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

8364:tafa1
gene id: 8364:tafa1
uniprot id: A0A803K8R5
uniprot id: A0A803KC50
names: Similarity
messages: Belongs to the TAFA family.

8364:pou2f3
gene id: 8364:pou2f3
uniprot id: A0A8J1JWA7
uniprot id: A0A8J1JWB5
uniprot id: A0A8J1K0D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus

8364:slc25a40
gene id: 8364:slc25a40
uniprot id: Q6P316
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane
messages: Probable mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles (By similarity). Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters (By similarity).

8364:vopp1
gene id: 8364:vopp1
uniprot id: A0A8J0SR75
uniprot id: Q0V9A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VOPP1/ECOP family.
messages: Cytoplasmic vesicle membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: May be involved in the transcriptional activity of NFKB1. May regulate WWOX role as tumor suppressor.
messages: Membrane

8364:cpd
gene id: 8364:cpd
uniprot id: A0A803JS61
names: Similarity
messages: Belongs to the peptidase M14 family.

8364:LOC100497260
gene id: 8364:LOC100497260
uniprot id: A0A8J0SUF5
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

8364:lin7c
gene id: 8364:lin7c
uniprot id: A0A803K6I0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-7 family.
messages: Cell junction
messages: Cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.

8364:igf2bp3
gene id: 8364:igf2bp3
uniprot id: A0A8J0PJ32
uniprot id: F6SCY4
names: Similarity
messages: Belongs to the RRM IMP/VICKZ family.

8364:mmp3
gene id: 8364:mmp3
uniprot id: F6UAM2
uniprot id: Q28J86
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

8364:bambi
gene id: 8364:bambi
uniprot id: Q6F2E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BAMBI family.
messages: Membrane
messages: Negatively regulates TGF-beta signaling.

8364:ccn2
gene id: 8364:ccn2
uniprot id: F7CHN4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:ano10l
gene id: 8364:ano10l
uniprot id: A0A6I8PTE5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:fam219a
gene id: 8364:fam219a
uniprot id: A0A8J1IZ77
uniprot id: A0A8J1IZ90
names: Similarity
messages: Belongs to the FAM219 family.

8364:pomk
gene id: 8364:pomk
uniprot id: F7E5Y2
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif.

8364:LOC100485981
gene id: 8364:LOC100485981
uniprot id: A0A6I8RWS1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:LOC100497569
gene id: 8364:LOC100497569
uniprot id: A0A8J0QWL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 11 family.
messages: Golgi stack membrane
messages: Membrane

8364:foxi4.2
gene id: 8364:foxi4.2
uniprot id: Q6P2Z3
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription factor. Essential for ventral specification of the early cephalic (head) ectoderm during gastrulation, playing a role in the 'non-neural' versus 'neural' cell fate choice. Binds to DNA via the target sequence 5'-[AG]TAAA[CT]A-3', with 5'-ATAAACA-3' being the preferred binding site (By similarity).

8364:ncib
gene id: 8364:ncib
uniprot id: A0A803JBZ8
names: Similarity
messages: Belongs to the MHC class I family.

8364:b4galnt4
gene id: 8364:b4galnt4
uniprot id: A0JP97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane
messages: Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.

8364:smad3
gene id: 8364:smad3
uniprot id: A0A8J0T288
uniprot id: Q68EP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

8364:LOC116411030
gene id: 8364:LOC116411030
uniprot id: A0A8J1JL97
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:prim1
gene id: 8364:prim1
uniprot id: Q6NVT9
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

8364:tmem111
gene id: 8364:tmem111
uniprot id: A0A803JF83
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

8364:LOC100494099
gene id: 8364:LOC100494099
uniprot id: A0A8J0QJI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

8364:MGC147402
gene id: 8364:MGC147402
uniprot id: A0A6I8PPP1
uniprot id: Q08D08
names: Similarity
messages: Belongs to the HMGA family.

8364:frem1l
gene id: 8364:frem1l
uniprot id: A0A8J0R0X7
names: Similarity
messages: Belongs to the FRAS1 family.

8364:ndufb4
gene id: 8364:ndufb4
uniprot id: A4QNM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

8364:slc66a2.2
gene id: 8364:slc66a2.2
uniprot id: Q08CY6
names: Subcellular Location Annotation
messages: Membrane

8364:slc26a3.3
gene id: 8364:slc26a3.3
uniprot id: F6WBF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
messages: Membrane

8364:scmh1
gene id: 8364:scmh1
uniprot id: A0A6I8R2E0
uniprot id: A0A8J0SE55
uniprot id: Q6DJ53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

8364:rnf13
gene id: 8364:rnf13
uniprot id: Q66JJ1
names: Subcellular Location Annotation
messages: Membrane

8364:LOC101734646
gene id: 8364:LOC101734646
uniprot id: A0A8J1JWU5
names: Similarity
messages: Belongs to the leprecan family.

8364:eya3
gene id: 8364:eya3
uniprot id: A0A8J0SY61
uniprot id: B1WAZ7
uniprot id: F7BR08
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

8364:plk1
gene id: 8364:plk1
uniprot id: P62205
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by phosphorylation on Thr-201 during M phase.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Interacts with plk1 and kif2a. Interacts with fbxo5.
messages: Midbody
messages: Nucleus
messages: Plays multiple essential roles during mitosis. Phosphorylates the N-terminal domain of cdc25, which leads to cyclin b-cdc2 activation and mitotic entry. Also required for organization of bipolar spindles, and for exit from mitosis. Phosphorylates tpx2 (By similarity).
messages: Protein levels are down-regulated by proteasomal degradation in anaphase.
messages: centrosome
messages: spindle

8364:dync1i1
gene id: 8364:dync1i1
uniprot id: A8WGE7
names: Similarity
messages: Belongs to the dynein intermediate chain family.

8364:ctbs
gene id: 8364:ctbs
uniprot id: Q5HZT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family.
messages: Lysosome

8364:cox6b1
gene id: 8364:cox6b1
uniprot id: Q6DEQ9
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

8364:cdc73
gene id: 8364:cdc73
uniprot id: Q5BKG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC73 family.
messages: Nucleus

8364:hip1r
gene id: 8364:hip1r
uniprot id: A0A7D9NJR8
uniprot id: B1H2Q0
names: Similarity
messages: Belongs to the SLA2 family.

8364:soho1
gene id: 8364:soho1
uniprot id: A0A1B8Y8H7
names: Subcellular Location Annotation
messages: Nucleus

8364:jup
gene id: 8364:jup
uniprot id: A0A6I8SDW2
uniprot id: Q6P259
names: Similarity
messages: Belongs to the beta-catenin family.

8364:opn6a
gene id: 8364:opn6a
uniprot id: A4II19
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100492749
gene id: 8364:LOC100492749
uniprot id: A0A8J0SC43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:tnpo3
gene id: 8364:tnpo3
uniprot id: A0A6I8SNB2
uniprot id: A0A7D9NK70
names: Subcellular Location Annotation
messages: Cytoplasm

8364:cd36
gene id: 8364:cd36
uniprot id: F7A485
names: Similarity
messages: Belongs to the CD36 family.

8364:LOC100488132
gene id: 8364:LOC100488132
uniprot id: A0A8J1JYM5
names: Similarity
messages: Belongs to the FXYD family.

8364:LOC101730267
gene id: 8364:LOC101730267
uniprot id: A0A8J0R021
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:cyp2a6.3
gene id: 8364:cyp2a6.3
uniprot id: A0A6I8SMY9
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:LOC100216114
gene id: 8364:LOC100216114
uniprot id: A0A6I8RT34
uniprot id: A0A8J1J181
uniprot id: L7MUJ8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

8364:LOC116411631
gene id: 8364:LOC116411631
uniprot id: A0A1B8XZW2
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:synpr
gene id: 8364:synpr
uniprot id: A0A803JPB6
uniprot id: Q08CZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

8364:ntmt1
gene id: 8364:ntmt1
uniprot id: A0A803J4K1
uniprot id: B1H2P7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. NTM1 family.
messages: Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on target proteins.
messages: Nucleus

8364:slc1a7
gene id: 8364:slc1a7
uniprot id: A0A6I8RPW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

8364:tmem216
gene id: 8364:tmem216
uniprot id: A0A8J1J5Z0
names: Subcellular Location Annotation
messages: Membrane

8364:LOC733858
gene id: 8364:LOC733858
uniprot id: A0A6I8Q0A8
uniprot id: A0A6I8Q6Q1
uniprot id: Q08D67
names: Subcellular Location Annotation
messages: Membrane

8364:inpp4b
gene id: 8364:inpp4b
uniprot id: A0A8J1J0J3
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

8364:LOC108644783
gene id: 8364:LOC108644783
uniprot id: A0A8J1JTK8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC100485927
gene id: 8364:LOC100485927
uniprot id: A0A8J0T021
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
messages: Membrane

8364:ddx41
gene id: 8364:ddx41
uniprot id: A0A8J0QSV9
uniprot id: F6VY98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX41 subfamily.
messages: Cytoplasm
messages: Nucleus

8364:dtwd1
gene id: 8364:dtwd1
uniprot id: Q28I29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDD superfamily. DTWD1 family.
messages: Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20 in the D-loop of several cytoplasmic tRNAs (acp3U(20)).
messages: Nucleus

8364:LOC100492352
gene id: 8364:LOC100492352
uniprot id: A0A8J0QYZ5
names: Similarity
messages: Belongs to the cyclin family.

8364:vil1
gene id: 8364:vil1
uniprot id: A4II76
uniprot id: F7DCH9
names: Similarity
messages: Belongs to the villin/gelsolin family.

8364:casd1
gene id: 8364:casd1
uniprot id: A0A6I8RSU1
uniprot id: A0A8J0SPB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PC-esterase family. CASD1 subfamily.
messages: Membrane

8364:ltb4r
gene id: 8364:ltb4r
uniprot id: A0A6I8S269
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

8364:actn2
gene id: 8364:actn2
uniprot id: Q6DF05
names: Similarity
messages: Belongs to the alpha-actinin family.

8364:grin3b
gene id: 8364:grin3b
uniprot id: A0A6I8PVN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8364:or5f1l2.1
gene id: 8364:or5f1l2.1
uniprot id: A0A8J0QKE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:psmc3ip
gene id: 8364:psmc3ip
uniprot id: A0A8J0SST5
uniprot id: B2RZG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HOP2 family.
messages: Nucleus

8364:kif20a
gene id: 8364:kif20a
uniprot id: A0A6I8Q3P1
uniprot id: A0A6I8R349
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8364:LOC116411693
gene id: 8364:LOC116411693
uniprot id: A0A803JEC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted

8364:LOC105946390
gene id: 8364:LOC105946390
uniprot id: A0A8J0SD75
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:ehd1
gene id: 8364:ehd1
uniprot id: Q6DIP4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

8364:ccdc149
gene id: 8364:ccdc149
uniprot id: A0A6I8RJX9
uniprot id: A0A6I8SAE9
uniprot id: A0A8J1J048
names: Similarity
messages: Belongs to the CCDC149 family.

8364:miox
gene id: 8364:miox
uniprot id: A0A8J0QSX3
uniprot id: A0A8J1JD86
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myo-inositol oxygenase family.
messages: Binds 2 iron ions per subunit.
messages: Cytoplasm

8364:slco1b3
gene id: 8364:slco1b3
uniprot id: F7B8B6
uniprot id: Q4VA80
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:musk
gene id: 8364:musk
uniprot id: F6X9J2
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:p3h1
gene id: 8364:p3h1
uniprot id: A1A5F1
names: Similarity
messages: Belongs to the leprecan family.

8364:LOC100494977
gene id: 8364:LOC100494977
uniprot id: A0A6I8PSY2
names: Similarity
messages: Belongs to the peptidase S1B family.

8364:esrrgr
gene id: 8364:esrrgr
uniprot id: A0A8J0QV17
uniprot id: A0A8J0SWY9
uniprot id: F6Y0A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

8364:oxtr
gene id: 8364:oxtr
uniprot id: F7C7K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane

8364:cxcl13
gene id: 8364:cxcl13
uniprot id: A0A8J1IZC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

8364:uimc1
gene id: 8364:uimc1
uniprot id: A0JM80
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAP80 family.
messages: Component of the BRCA1-A complex.
messages: Nucleus
messages: The tandem UIM domains form a continuous 60 Angstrom-long alpha-helix and mediate binding to 'Lys-63'-linked ubiquitins. UIM1 and UIM2 bind to the proximal and distal ubiquitin moieties and recognize an 'Ile-44'-centered hydrophobic patch. Since UIMs don't interact with the 'Lys-63' isopeptide bond the UIM-linker region between the 2 UIM domains determines the selectivity for 'Lys-63'-linkage, and its length is very important for specificity (By similarity).
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin (By similarity).

8364:pus7l
gene id: 8364:pus7l
uniprot id: A0A803KK61
uniprot id: A9JTM8
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

8364:grin2a
gene id: 8364:grin2a
uniprot id: F6X9P6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

8364:stk32b
gene id: 8364:stk32b
uniprot id: A0A6I8S7S8
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC100491404
gene id: 8364:LOC100491404
uniprot id: A0A8J0STW2
names: Similarity
messages: Belongs to the HEBP family.

8364:opn4
gene id: 8364:opn4
uniprot id: A0A6I8Q0P6
uniprot id: A0A6I8S6Q1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:arl6
gene id: 8364:arl6
uniprot id: A0A6I8QQ16
uniprot id: F7DPC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: cilium membrane

8364:stpg1
gene id: 8364:stpg1
uniprot id: A0A6I8PQW2
uniprot id: A0A6I8SQ85
uniprot id: A0A8J1J4G0
uniprot id: A0A8J1J4G2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:rack1
gene id: 8364:rack1
uniprot id: A0A8J0SKM2
uniprot id: Q6DIV0
names: Similarity
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.

8364:leo1
gene id: 8364:leo1
uniprot id: F7EB62
names: Similarity
messages: Belongs to the LEO1 family.

8364:dglucy
gene id: 8364:dglucy
uniprot id: Q08D26
names: Similarity
messages: Belongs to the D-glutamate cyclase family.

8364:agbl1
gene id: 8364:agbl1
uniprot id: F6QLJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

8364:rsbn1l
gene id: 8364:rsbn1l
uniprot id: Q28DE6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins.
messages: Nucleus

8364:tubz1
gene id: 8364:tubz1
uniprot id: A0A6I8RNG6
uniprot id: A0A8J1JQ43
uniprot id: A0A8J1JSK8
uniprot id: F7D152
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Nucleus
messages: centriole
messages: cilium

8364:pde5a
gene id: 8364:pde5a
uniprot id: A0A6I8RCB3
uniprot id: A0A6I8T2N5
uniprot id: A0A8J0SPX1
uniprot id: A0A8J0SSS7
uniprot id: Q0V9K9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8364:LOC108644844
gene id: 8364:LOC108644844
uniprot id: A0A8J1JTM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8364:tmem35b
gene id: 8364:tmem35b
uniprot id: A0A6I8PVX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

8364:kif5c
gene id: 8364:kif5c
uniprot id: A0A6I8RVQ6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8364:LOC100496940
gene id: 8364:LOC100496940
uniprot id: A0A8J0QLI4
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

8364:arhgef2
gene id: 8364:arhgef2
uniprot id: A0A803J8U5
uniprot id: A0A803JYM3
uniprot id: Q6NY14
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Golgi apparatus
messages: Vesicle
messages: spindle
messages: tight junction

8364:grhl2
gene id: 8364:grhl2
uniprot id: A0A8J1JMU8
uniprot id: A0A8J1JRJ3
uniprot id: Q5M7R9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. Grainyhead subfamily.
messages: GRHL genes (GRHL1, GRHL2 and GRHL3) show a paradoxal lack of redundancy despite their extensive sequence identity in the DNA-binding and protein dimerization domains and the fact that the core consensus DNA binding sites are identical. They have related but remarkably different functions during embryogenesis because of their differential spatiotemporal expression patterns during development.
messages: Membrane
messages: Nucleus
messages: Transcription factor playing an important role in primary neurulation and in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes.

8364:bcar1
gene id: 8364:bcar1
uniprot id: B2GUM2
uniprot id: F7ACI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

8364:pdgfrl
gene id: 8364:pdgfrl
uniprot id: A0A803KIM3
names: Subunit
messages: Forms a complex composed of PDGFRL, TNK2 and GRB2.

8364:ren
gene id: 8364:ren
uniprot id: A0A6I8ST60
uniprot id: A0A8J1J6Q2
names: Similarity
messages: Belongs to the peptidase A1 family.

8364:meaf6
gene id: 8364:meaf6
uniprot id: A0A8J0S7F9
uniprot id: Q68ER9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF6 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (By similarity).
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
messages: Component of the NuA4 histone acetyltransferase complex. Component of the hbo1 complex. Component of the moz/morf complex (By similarity).
messages: Component of the NuA4 histone acetyltransferase complex. Component of the hbo1 complex. Component of the moz/morf complex.
messages: kinetochore
messages: nucleolus

8364:tmsb15a
gene id: 8364:tmsb15a
uniprot id: A0A8J0QU69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

8364:usp47
gene id: 8364:usp47
uniprot id: A1A5G2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP47 subfamily.
messages: Cytoplasm
messages: Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (polb), stabilizing polb thereby playing a role in base-excision repair (BER).

8364:LOC116406781
gene id: 8364:LOC116406781
uniprot id: A0A803JY47
names: Similarity
messages: Belongs to the cyclin family.

8364:LOC613063
gene id: 8364:LOC613063
uniprot id: A8WGW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Lysosome

8364:pglyrp1
gene id: 8364:pglyrp1
uniprot id: A0A803JNK5
uniprot id: Q5FVY1
names: Function
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems.

8364:arhgdig
gene id: 8364:arhgdig
uniprot id: A0A6I8Q2L0
uniprot id: Q68F87
names: Similarity
messages: Belongs to the Rho GDI family.

8364:capn5
gene id: 8364:capn5
uniprot id: Q6DIP0
names: Similarity
messages: Belongs to the peptidase C2 family.

8364:LOC100127860
gene id: 8364:LOC100127860
uniprot id: A0A6I8PT53
uniprot id: A9JTV3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:LOC101730903
gene id: 8364:LOC101730903
uniprot id: A0A8J0R8K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:cltcl1
gene id: 8364:cltcl1
uniprot id: A0A6I8QJZ5
uniprot id: A0A8J0R019
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

8364:spo11
gene id: 8364:spo11
uniprot id: A0A6I8R4Z2
uniprot id: A0A8J1IWE9
uniprot id: F7API5
names: Similarity
messages: Belongs to the TOP6A family.

8364:hsp30c
gene id: 8364:hsp30c
uniprot id: A0A8J0QYR3
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

8364:ezr
gene id: 8364:ezr
uniprot id: Q5BJ89
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

8364:pold3
gene id: 8364:pold3
uniprot id: A0A8J0PI21
uniprot id: A0A8J1J1W6
names: Subcellular Location Annotation
messages: Nucleus

8364:myog
gene id: 8364:myog
uniprot id: Q0IIX1
uniprot id: Q28J48
names: Subcellular Location Annotation
messages: Nucleus

8364:gprc5a
gene id: 8364:gprc5a
uniprot id: F7DX22
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:pik3c2g
gene id: 8364:pik3c2g
uniprot id: A0A803KDN3
uniprot id: A0A8J1JB70
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

8364:nkx3-2
gene id: 8364:nkx3-2
uniprot id: A0A6I8R8A6
names: Subcellular Location Annotation
messages: Nucleus

8364:proc
gene id: 8364:proc
uniprot id: Q5FVZ2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:isl2
gene id: 8364:isl2
uniprot id: C8CMG0
names: Subcellular Location Annotation
messages: Nucleus

8364:mxd3
gene id: 8364:mxd3
uniprot id: Q28DB3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (By similarity).
messages: Nucleus
messages: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3' (By similarity).

8364:LOC100485506
gene id: 8364:LOC100485506
uniprot id: A0A8J0SEC4
names: Subcellular Location Annotation
messages: Membrane

8364:LOC116407958
gene id: 8364:LOC116407958
uniprot id: A0A8J1IZW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel MCLC family.
messages: Membrane

8364:abca5
gene id: 8364:abca5
uniprot id: B4F751
names: Subcellular Location Annotation
messages: Membrane

8364:tspan12
gene id: 8364:tspan12
uniprot id: A0A6I8RX31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8364:galnt5
gene id: 8364:galnt5
uniprot id: A0A6I8SE68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Membrane

8364:tgm5
gene id: 8364:tgm5
uniprot id: F6Z5P5
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

8364:adra1a
gene id: 8364:adra1a
uniprot id: A0A6I8RMZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: caveola

8364:cdh9
gene id: 8364:cdh9
uniprot id: F6SRQ2
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane

8364:hsd17b7
gene id: 8364:hsd17b7
uniprot id: A0A8J0PH40
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.

8364:supt3h
gene id: 8364:supt3h
uniprot id: A0A6I8RWV9
uniprot id: A0A8J0STR6
uniprot id: A0A8J0SVA7
uniprot id: A0A8J1JKB9
uniprot id: Q6P863
names: Subcellular Location Annotation
messages: Nucleus

8364:slc47a2
gene id: 8364:slc47a2
uniprot id: A0A8J1JXU2
uniprot id: A0A8J1K0H7
uniprot id: A0A8J1K214
uniprot id: A4IIS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Cell membrane
messages: Membrane
messages: Multidrug efflux pump that functions as a H(+)/organic cation antiporter. Mediates the secretion of cationic compounds including drugs, toxins and endogenous metabolites. Plays a role physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney and liver, into urine and bile respectively.

8364:LOC105948139
gene id: 8364:LOC105948139
uniprot id: A0A8J1IPV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.

8364:LOC116410833
gene id: 8364:LOC116410833
uniprot id: A0A8J1JIZ7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:ttc27
gene id: 8364:ttc27
uniprot id: A0A6I8RZ65
names: Similarity
messages: Belongs to the TTC27 family.

8364:clul1
gene id: 8364:clul1
uniprot id: A0A6I8QZ83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clusterin family.
messages: Secreted

8364:ccnb1
gene id: 8364:ccnb1
uniprot id: B0BLV2
uniprot id: F7ENC4
names: Similarity
messages: Belongs to the cyclin family.

8364:LOC116409614
gene id: 8364:LOC116409614
uniprot id: A0A8J1J8L5
names: Subcellular Location Annotation
messages: Membrane

8364:pam
gene id: 8364:pam
uniprot id: A0A6I8RMI2
uniprot id: A0A6I8SAV5
uniprot id: A0A8J0QFI1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Binds 2 Cu(2+) ions per subunit.
messages: Binds one Zn(2+) ion per subunit.
messages: In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.
messages: In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Membrane
messages: secretory vesicle membrane

8364:cacna1a
gene id: 8364:cacna1a
uniprot id: A0A8J1JBR0
uniprot id: A0A8J1JBR1
uniprot id: A0A8J1JBR3
uniprot id: A0A8J1JBR5
uniprot id: A0A8J1JE66
uniprot id: A0A8J1JF79
uniprot id: A0A8J1JF83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane

8364:slc7a4
gene id: 8364:slc7a4
uniprot id: Q0IIS6
names: Subcellular Location Annotation
messages: Membrane

8364:agtpbp1
gene id: 8364:agtpbp1
uniprot id: A9JRL3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins.
messages: Mitochondrion
messages: Nucleus
messages: cytosol

8364:hspa14
gene id: 8364:hspa14
uniprot id: Q5FVX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Component of ribosome-associated complex (RAC).
messages: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state.
messages: cytosol

8364:parn
gene id: 8364:parn
uniprot id: A0A6I8RT08
uniprot id: A0A8J0QG33
uniprot id: B5DFR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Cytoplasm

8364:dnah2
gene id: 8364:dnah2
uniprot id: A0A8J1JEG2
uniprot id: A0A8J1JFI7
uniprot id: F7DZ81
names: Similarity
messages: Belongs to the dynein heavy chain family.

8364:tnfaip8
gene id: 8364:tnfaip8
uniprot id: Q28I19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a negative mediator of apoptosis.
messages: Belongs to the TNFAIP8 family.
messages: Cytoplasm

8364:pax7
gene id: 8364:pax7
uniprot id: A0A8J1JVS7
uniprot id: A0A8J1JVS8
uniprot id: A0A8J1JVT1
uniprot id: A0A8J1JY85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

8364:taf7
gene id: 8364:taf7
uniprot id: A0A803KHG0
uniprot id: F7BJX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

8364:notch2
gene id: 8364:notch2
uniprot id: A0A6I8RH04
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

8364:crygdl.2
gene id: 8364:crygdl.2
uniprot id: A0A8J0QP85
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:cenpl
gene id: 8364:cenpl
uniprot id: Q28HN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-L/IML3 family.
messages: Nucleus
messages: Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
messages: centromere

8364:grpel1
gene id: 8364:grpel1
uniprot id: Q5BJ46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

8364:LOC100492191
gene id: 8364:LOC100492191
uniprot id: A0A8J1JBX9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:sgf29
gene id: 8364:sgf29
uniprot id: B0BM70
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100490733
gene id: 8364:LOC100490733
uniprot id: A0A8J0R4J3
names: Similarity
messages: Belongs to the NXF family.

8364:tiparp
gene id: 8364:tiparp
uniprot id: A8E4V7
names: Similarity
messages: Belongs to the ARTD/PARP family.

8364:lmod2
gene id: 8364:lmod2
uniprot id: B1H1C3
names: Subcellular Location Annotation
messages: cytoskeleton
messages: sarcomere

8364:nsf
gene id: 8364:nsf
uniprot id: A0A8J0SC23
uniprot id: Q0IJ19
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

8364:map1lc3c
gene id: 8364:map1lc3c
uniprot id: Q28FC7
names: Similarity
messages: Belongs to the ATG8 family.

8364:cacnb4
gene id: 8364:cacnb4
uniprot id: A0A6I8SB14
uniprot id: B5DDZ7
names: Similarity
messages: Belongs to the calcium channel beta subunit family.

8364:fgf16
gene id: 8364:fgf16
uniprot id: A0A6I8QXV8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

8364:LOC394904
gene id: 8364:LOC394904
uniprot id: F6VAG8
names: Similarity
messages: Belongs to the glutamine synthetase family.

8364:hsp30d
gene id: 8364:hsp30d
uniprot id: A0A8J0QTN0
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

8364:cdh15
gene id: 8364:cdh15
uniprot id: A0A6I8S5C1
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane

8364:LOC116412231
gene id: 8364:LOC116412231
uniprot id: A0A8J1JVC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:cxcl10
gene id: 8364:cxcl10
uniprot id: A0A8J0QXD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

8364:LOC100145789
gene id: 8364:LOC100145789
uniprot id: A0A6I8RJA0
uniprot id: B1WBI6
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

8364:tpst2
gene id: 8364:tpst2
uniprot id: A0A8J0PJA9
uniprot id: F6ULQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

8364:trappc13
gene id: 8364:trappc13
uniprot id: A0A5S6JXN2
uniprot id: A0A8J0PIA5
uniprot id: A0A8J0SK23
uniprot id: Q0VFT9
names: Similarity
names: Subunit
messages: Belongs to the TRAPPC13 family.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.

8364:exoc3l1
gene id: 8364:exoc3l1
uniprot id: F6SDG7
names: Similarity
messages: Belongs to the SEC6 family.

8364:dgat1
gene id: 8364:dgat1
uniprot id: A0A803JY67
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Homodimer or homotetramer; both forms have similar enzymatic activities.
messages: Membrane

8364:LOC100489917
gene id: 8364:LOC100489917
uniprot id: A0A803JPZ5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC101730806
gene id: 8364:LOC101730806
uniprot id: A0A1B8Y806
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:rpap1
gene id: 8364:rpap1
uniprot id: A0A6I8Q111
uniprot id: A0A8J0SU99
names: Similarity
messages: Belongs to the RPAP1 family.

8364:t2r47
gene id: 8364:t2r47
uniprot id: Q2AB40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:LOC100493717
gene id: 8364:LOC100493717
uniprot id: A0A8J1JWW2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:oxa1l
gene id: 8364:oxa1l
uniprot id: A7MC69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

8364:plxnb1
gene id: 8364:plxnb1
uniprot id: A0A6I8QUJ3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

8364:sod1
gene id: 8364:sod1
uniprot id: Q0IIW3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homodimer.
messages: Nucleus

8364:mef2a
gene id: 8364:mef2a
uniprot id: F6YMG1
names: Subcellular Location Annotation
messages: Nucleus

8364:ide
gene id: 8364:ide
uniprot id: A0A6I8Q1D4
uniprot id: A0A8J0QUS3
names: Similarity
messages: Belongs to the peptidase M16 family.

8364:LOC101733889
gene id: 8364:LOC101733889
uniprot id: A0A8J1JEL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:LOC100487005
gene id: 8364:LOC100487005
uniprot id: A0A6I8Q8J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

8364:dhx58
gene id: 8364:dhx58
uniprot id: A0A6I8SQF9
uniprot id: A0A8J0R3V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

8364:phc2
gene id: 8364:phc2
uniprot id: A0A803J520
uniprot id: A0A803KGE6
uniprot id: A0A8J1JUB9
uniprot id: A8E4V3
names: Subcellular Location Annotation
messages: Nucleus

8364:slc13a1
gene id: 8364:slc13a1
uniprot id: A0A6I8SEG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

8364:lipa
gene id: 8364:lipa
uniprot id: A0A8J0PGJ1
uniprot id: A0A8J0SIP2
uniprot id: Q5FV95
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

8364:LOC394448
gene id: 8364:LOC394448
uniprot id: A0A8J0SX26
uniprot id: Q28GP5
names: Similarity
messages: Belongs to the cyclin family.

8364:ndufa2
gene id: 8364:ndufa2
uniprot id: A4IH72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

8364:dpep1
gene id: 8364:dpep1
uniprot id: A0A8J0QKC1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Homodimer; disulfide-linked.
messages: Membrane

8364:adcy7
gene id: 8364:adcy7
uniprot id: A8WH07
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

8364:sh3rf1
gene id: 8364:sh3rf1
uniprot id: A0A5S6KPN6
uniprot id: B7ZTV8
uniprot id: F6TM25
uniprot id: Q28E95
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autoubiquitinated. Ubiquitinated by SH3RF2, leading to proteasome-mediated degradation.
messages: Belongs to the SH3RF family.
messages: Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Acts as a scaffold protein that contributes to the effective activation of the JNK signaling pathway.
messages: The RING finger domain is required for ubiquitin ligase activity and autoubiquitination.
messages: lamellipodium
messages: perinuclear region
messages: trans-Golgi network

8364:crispl
gene id: 8364:crispl
uniprot id: Q5BL94
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Belongs to the UPF0524 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:dnajb14
gene id: 8364:dnajb14
uniprot id: Q28I38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway. Acts by determining hspa8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of hspa8/Hsc70: together with dnajb12, acts as a chaperone that promotes maturation of potassium channels by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nascent channel proteins is dependent on hspa8/Hsc70, the process of oligomerization of channel subunits is independent of hspa8/Hsc70.
messages: Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily.
messages: Endoplasmic reticulum membrane

8364:inhbc.1
gene id: 8364:inhbc.1
uniprot id: F7DD95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

8364:LOC100496360
gene id: 8364:LOC100496360
uniprot id: A0A8J1IZ26
names: Subcellular Location Annotation
messages: Cytoplasm

8364:LOC105945675
gene id: 8364:LOC105945675
uniprot id: A0A8J0SDC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elastin family.
messages: extracellular matrix

8364:wdr5
gene id: 8364:wdr5
uniprot id: Q5M786
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR5/wds family.
messages: Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity).
messages: Interacts with HCFC1. Probable component of complexes involved in histone modification such as the MLL1/MLL complex and the NSL complex.
messages: Nucleus

8364:LOC100489075
gene id: 8364:LOC100489075
uniprot id: A0A8J1IZL8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:usp21
gene id: 8364:usp21
uniprot id: A0A8J1IQS7
uniprot id: F7B8T1
names: Similarity
messages: Belongs to the peptidase C19 family.

8364:dcakd
gene id: 8364:dcakd
uniprot id: A4IH68
names: Similarity
messages: Belongs to the CoaE family.

8364:LOC116408382
gene id: 8364:LOC116408382
uniprot id: A0A8J1IZJ1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:nt5c3a
gene id: 8364:nt5c3a
uniprot id: A0A6I8S277
uniprot id: A0A8J1JR74
uniprot id: B0JZ91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

8364:cdkn1a
gene id: 8364:cdkn1a
uniprot id: A0A8J0QRF7
uniprot id: F7BLZ9
names: Similarity
messages: Belongs to the CDI family.

8364:LOC116410948
gene id: 8364:LOC116410948
uniprot id: A0A6I8SN29
uniprot id: A0A8J1JKV5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:ebf3
gene id: 8364:ebf3
uniprot id: A0A6I8RU69
uniprot id: A0A8J0QI57
uniprot id: A0A8J0QJB4
uniprot id: A0A8J0R0S5
uniprot id: A0A8J0R2X8
uniprot id: A0A8J0R4R2
uniprot id: A0A8J0R5C4
uniprot id: A0A8J0R5C9
uniprot id: A0A8J0R5T4
uniprot id: A0A8J0R5T8
uniprot id: A0A8J0T4N7
uniprot id: A0A8J1JUL9
uniprot id: A0A8J1JUM0
uniprot id: A0A8J1JUM1
uniprot id: A0A8J1JX17
uniprot id: A0A8J1JX22
uniprot id: A0A8J1JYG6
uniprot id: A0A8J1JYH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

8364:gch1
gene id: 8364:gch1
uniprot id: F7AIS0
names: Similarity
messages: Belongs to the GTP cyclohydrolase I family.

8364:pknox1
gene id: 8364:pknox1
uniprot id: A0A8J1J325
uniprot id: A0A8J1J5G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

8364:nkain2
gene id: 8364:nkain2
uniprot id: A0A803JJQ2
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Interacts with atp1b1 C-terminus.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:gapdh
gene id: 8364:gapdh
uniprot id: Q28HJ8
uniprot id: Q6DIU7
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

8364:LOC100124852
gene id: 8364:LOC100124852
uniprot id: A0A8J1IQN4
names: Similarity
messages: Belongs to the peptidase C1 family.

8364:LOC105946480
gene id: 8364:LOC105946480
uniprot id: A0A8J1J2X1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:hoxb8
gene id: 8364:hoxb8
uniprot id: A0A6I8Q024
uniprot id: A0A803J4T2
names: Subcellular Location Annotation
messages: Nucleus

8364:hoxa9
gene id: 8364:hoxa9
uniprot id: F7D5I9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

8364:LOC100487999
gene id: 8364:LOC100487999
uniprot id: A0A8J0QLA8
names: Similarity
messages: Belongs to the cyclin family.

8364:car1 predicted
gene id: 8364:car1_predicted
uniprot id: Q0VFA2
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

8364:tspan8
gene id: 8364:tspan8
uniprot id: Q28GV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8364:nfib
gene id: 8364:nfib
uniprot id: A0A6I8RST3
uniprot id: A0A6I8SJH4
uniprot id: A0A803KHX6
uniprot id: A0A8J0SF10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

8364:LOC100489421
gene id: 8364:LOC100489421
uniprot id: A0A803J4J2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:serpina3
gene id: 8364:serpina3
uniprot id: Q5M8K2
names: Similarity
messages: Belongs to the serpin family.

8364:LOC100487238
gene id: 8364:LOC100487238
uniprot id: A0A803K6V6
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

8364:zup1
gene id: 8364:zup1
uniprot id: Q28IN1
names: Similarity
names: Subunit
messages: Belongs to the peptidase C78 family. ZUFSP subfamily.
messages: Interacts with RPA1 and RPA2.

8364:tmem30a
gene id: 8364:tmem30a
uniprot id: Q6P880
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

8364:LOC100494882
gene id: 8364:LOC100494882
uniprot id: A0A8J0R8G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:prr5l
gene id: 8364:prr5l
uniprot id: A0A6I8PPY5
uniprot id: A0A803KDP7
uniprot id: A0A8J0R2K4
names: Similarity
messages: Belongs to the PROTOR family.

8364:ecrg4
gene id: 8364:ecrg4
uniprot id: Q5FVX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the augurin family.
messages: Cytoplasm
messages: Probable hormone that may attenuate cell proliferation and induce senescence in the central nervous system.
messages: Secreted

8364:LOC100498592
gene id: 8364:LOC100498592
uniprot id: A0A6I8RB21
uniprot id: A0A803JSN5
uniprot id: A0A8J0SPF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

8364:LOC116412147
gene id: 8364:LOC116412147
uniprot id: A0A8J1JUS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:cldn8.2
gene id: 8364:cldn8.2
uniprot id: A0A8J0QZ22
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8364:cyp46a1.1
gene id: 8364:cyp46a1.1
uniprot id: Q4VA77
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:gabrr1
gene id: 8364:gabrr1
uniprot id: A0A8J1JNX8
uniprot id: L7N2U7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:LOC100486303
gene id: 8364:LOC100486303
uniprot id: A0A8J0QYT3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:dnaja2
gene id: 8364:dnaja2
uniprot id: A0A803KJR3
names: Subcellular Location Annotation
messages: Membrane

8364:slit3
gene id: 8364:slit3
uniprot id: A0JM33
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:muc6
gene id: 8364:muc6
uniprot id: A0A8J1JF02
uniprot id: A0A8J1JF04
uniprot id: A0A8J1JF05
uniprot id: A0A8J1JHG2
uniprot id: A0A8J1JIG5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC116408261
gene id: 8364:LOC116408261
uniprot id: A0A8J1IZC0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:hsd17b1
gene id: 8364:hsd17b1
uniprot id: F7BSH6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8364:etv3
gene id: 8364:etv3
uniprot id: F7BM68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8364:lpar3
gene id: 8364:lpar3
uniprot id: A0A7D9NL13
uniprot id: A0A803JDI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100488770
gene id: 8364:LOC100488770
uniprot id: A0A8J0QJC4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

8364:sox5
gene id: 8364:sox5
uniprot id: B3DM43
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription factor involved in chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: sox5 and sox6 cooperatively bind with sox9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate sox9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes.

8364:LOC116408626
gene id: 8364:LOC116408626
uniprot id: A0A8J1J2Q8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:gng4
gene id: 8364:gng4
uniprot id: Q0VFL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8364:rragd
gene id: 8364:rragd
uniprot id: Q0VFL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

8364:mrpl17
gene id: 8364:mrpl17
uniprot id: Q5I032
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

8364:coq10b
gene id: 8364:coq10b
uniprot id: Q28GY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

8364:pcsk5
gene id: 8364:pcsk5
uniprot id: A0A6I8R6U7
uniprot id: A0A6I8RXE3
uniprot id: Q0P4Q8
names: Similarity
messages: Belongs to the peptidase S8 family.

8364:kcnd2
gene id: 8364:kcnd2
uniprot id: A0A6I8PXE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.
messages: Cell junction
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite
messages: dendritic spine

8364:nfe2l2
gene id: 8364:nfe2l2
uniprot id: Q68FB5
names: Similarity
messages: Belongs to the bZIP family. CNC subfamily.

8364:vegfc
gene id: 8364:vegfc
uniprot id: A0A7D9NJJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

8364:LOC116407740
gene id: 8364:LOC116407740
uniprot id: A0A8J1IV98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8364:mlf1
gene id: 8364:mlf1
uniprot id: A0A6I8PWF2
uniprot id: A0A6I8Q1H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

8364:otop2
gene id: 8364:otop2
uniprot id: A0A6I8S9L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

8364:LOC100486128
gene id: 8364:LOC100486128
uniprot id: A0A8J0STN9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:dld
gene id: 8364:dld
uniprot id: A0A6I8RYB7
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.
messages: acrosome
messages: flagellum

8364:prr15l
gene id: 8364:prr15l
uniprot id: A0A6I8PTB6
names: Similarity
messages: Belongs to the PRR15 family.

8364:bcan
gene id: 8364:bcan
uniprot id: A0A6I8QUP1
uniprot id: A0A8J1IP72
uniprot id: F7ATS6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:nptx1
gene id: 8364:nptx1
uniprot id: B2GUF3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:irx3
gene id: 8364:irx3
uniprot id: Q6NVN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Both up-regulates and down-regulates gene expression during neural development. Acts early in neural plate development to induce proneural gene expression and specify a neural precursor state. Also up-regulates repressors that prevent neuronal differentiation. Required during at least two stages of pronephros kidney development; during neurula stages, maintains transcription of key renal genes to define the size and identity of the pronephric anlage, probably in part through regulation of bmp-signaling. Subsequently required for proper formation of the intermediate tubule segment of the pronephros.
messages: Belongs to the TALE/IRO homeobox family.
messages: Expressed in the neural plate in overlapping patterns with other irx members, which all share an anterior border of expression. Outside the nervous system and at tailbud stages, expressed in the developing otic vesicle, branchial arches, prospective heart region and pronephros.
messages: Nucleus

8364:dbh
gene id: 8364:dbh
uniprot id: F7BL08
names: Similarity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.

8364:batf
gene id: 8364:batf
uniprot id: F7EMX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells.
messages: Belongs to the bZIP family.
messages: Cytoplasm
messages: Nucleus

8364:skil
gene id: 8364:skil
uniprot id: F7DVM3
names: Similarity
messages: Belongs to the SKI family.

8364:LOC116410537
gene id: 8364:LOC116410537
uniprot id: A0A8J1JJP1
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:ptdss2
gene id: 8364:ptdss2
uniprot id: A0A6I8QF04
uniprot id: Q08D11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (By similarity). Catalyzes the conversion of phosphatatidylethanolamine and does not act on phosphatidylcholine (By similarity). Can utilize both phosphatidylethanolamine (PE) plasmalogen and diacyl PE as substrate and the latter is six times better utilized, indicating the importance of an ester linkage at the sn-1 position (By similarity). Although it shows no sn-1 fatty acyl preference, exhibits significant preference towards docosahexaenoic acid (22:6n-3) compared with 18:1 or 20:4 at the sn-2 position (By similarity).
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:hk1
gene id: 8364:hk1
uniprot id: A0A6I8SCZ6
uniprot id: A4II49
names: Similarity
messages: Belongs to the hexokinase family.

8364:mtmr8
gene id: 8364:mtmr8
uniprot id: A0A6I8QYJ5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

8364:tubgcp4
gene id: 8364:tubgcp4
uniprot id: A0A6I8RAR2
uniprot id: Q05AR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

8364:drd1
gene id: 8364:drd1
uniprot id: F6RJ06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:oxct1
gene id: 8364:oxct1
uniprot id: Q66KJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
messages: Mitochondrion

8364:unc5c
gene id: 8364:unc5c
uniprot id: A0A6I8QSQ2
uniprot id: A0A6I8SBP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

8364:rpl3
gene id: 8364:rpl3
uniprot id: B0BM43
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

8364:tamm41
gene id: 8364:tamm41
uniprot id: A0A8J1JKQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Mitochondrion inner membrane

8364:kalrn
gene id: 8364:kalrn
uniprot id: A0A8J1ISB5
uniprot id: A0A8J1ISC1
uniprot id: A0A8J1ISC2
uniprot id: A0A8J1ISC8
uniprot id: A0A8J1ISD5
uniprot id: A0A8J1IUR3
uniprot id: A0A8J1IUR9
uniprot id: A0A8J1IUS6
uniprot id: A0A8J1IVI7
uniprot id: A0A8J1IVJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cell membrane
messages: Cytoplasm

8364:rps12
gene id: 8364:rps12
uniprot id: A0A8J0SE13
uniprot id: Q68EP7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

8364:mtcl1
gene id: 8364:mtcl1
uniprot id: A0A6I8QH37
uniprot id: A0A6I8RIX6
uniprot id: A0A8J1JNR9
uniprot id: A0A8J1JNS3
uniprot id: A0A8J1JNT0
uniprot id: A0A8J1JR80
names: Similarity
messages: Belongs to the SOGA family.

8364:ror1
gene id: 8364:ror1
uniprot id: A0A6I8QGM9
uniprot id: A0A6I8RQP3
uniprot id: A0A6I8SZJ2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:lxn
gene id: 8364:lxn
uniprot id: A0A803JYP4
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

8364:macroh2a1
gene id: 8364:macroh2a1
uniprot id: A0A6I8SR74
uniprot id: Q5FWR2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.

8364:atp5f1e
gene id: 8364:atp5f1e
uniprot id: A0A8J1J1K6
names: Function
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

8364:ccnd2
gene id: 8364:ccnd2
uniprot id: A0A803J2X6
names: Similarity
messages: Belongs to the cyclin family.

8364:rabggta
gene id: 8364:rabggta
uniprot id: Q6DIR3
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.

8364:vps25
gene id: 8364:vps25
uniprot id: F6T240
names: Similarity
messages: Belongs to the VPS25 family.

8364:memo1
gene id: 8364:memo1
uniprot id: A0A8J0SNP4
uniprot id: Q6DJ03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MEMO1 family.
messages: Interacts with ERBB2.
messages: May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling (By similarity).

8364:LOC116409577
gene id: 8364:LOC116409577
uniprot id: A0A8J1J8G8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:c6orf120
gene id: 8364:c6orf120
uniprot id: Q6DIW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0669 family.
messages: Secreted

8364:anxa7
gene id: 8364:anxa7
uniprot id: A0A6I8R2J2
uniprot id: Q6NVI8
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

8364:rars1
gene id: 8364:rars1
uniprot id: Q6P1S4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis.
messages: Monomer; also part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro.
messages: The alpha-helical N-terminus (residues 1-72) mediates interaction with AIMP1 and thereby contributes to the assembly of the multisynthetase complex.
messages: cytosol

8364:galk1
gene id: 8364:galk1
uniprot id: F6W018
uniprot id: Q0VFQ1
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

8364:psme3ip1
gene id: 8364:psme3ip1
uniprot id: B1H137
names: Subcellular Location Annotation
messages: Nucleus

8364:c7orf25
gene id: 8364:c7orf25
uniprot id: A0A5S6K347
uniprot id: Q5BKL1
names: Similarity
messages: Belongs to the UPF0415 family.

8364:ucma
gene id: 8364:ucma
uniprot id: Q28HK1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UCMA family.
messages: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.
messages: Proteolytically cleaved by a furin-like convertase to generate a persistent C-terminal fragment found in almost the entire cartilage matrix, and affecting osteoblast differentiation.
messages: Sulfated on tyrosine residues.
messages: extracellular matrix

8364:LOC116408402
gene id: 8364:LOC116408402
uniprot id: A0A8J1IZM1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:hrh1
gene id: 8364:hrh1
uniprot id: A0A803KEZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:h2ac16
gene id: 8364:h2ac16
uniprot id: A0A1B8Y828
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:LOC116408244
gene id: 8364:LOC116408244
uniprot id: A0A8J1IZ44
uniprot id: A0A8J1IZ64
uniprot id: A0A8J1J1J4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC116412167
gene id: 8364:LOC116412167
uniprot id: A0A8J1JUV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100490828
gene id: 8364:LOC100490828
uniprot id: A0A8J1ISF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P2X receptor family.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

8364:avd
gene id: 8364:avd
uniprot id: A7YYL1
names: Similarity
messages: Belongs to the avidin/streptavidin family.

8364:hyal1
gene id: 8364:hyal1
uniprot id: A0A6I8SP25
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

8364:tmem170b
gene id: 8364:tmem170b
uniprot id: A0A8J0SUU7
uniprot id: A0A8J1JQ17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

8364:tm4sf18
gene id: 8364:tm4sf18
uniprot id: A0A6I8SK37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

8364:LOC100490068
gene id: 8364:LOC100490068
uniprot id: A0A8J0QI00
names: Subcellular Location Annotation
messages: Nucleus

8364:plb1
gene id: 8364:plb1
uniprot id: A0A8J1JKC5
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily.
messages: Cell membrane
messages: Membrane

8364:ephb4
gene id: 8364:ephb4
uniprot id: A0A8J1JFR7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:taf1
gene id: 8364:taf1
uniprot id: A0A6I8QKD7
uniprot id: A0A8J0SVT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF1 family.
messages: Nucleus

8364:LOC100496232
gene id: 8364:LOC100496232
uniprot id: A0A8J0QT78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

8364:timm13
gene id: 8364:timm13
uniprot id: Q28BN8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

8364:suds3
gene id: 8364:suds3
uniprot id: A0A8J0QUH7
names: Subcellular Location Annotation
messages: Nucleus

8364:tma16
gene id: 8364:tma16
uniprot id: A0A6I8RQG1
uniprot id: A4II15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with pre-60S ribosomal particles.
messages: Belongs to the TMA16 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit in the nucleus.
messages: Nucleus

8364:galntl6
gene id: 8364:galntl6
uniprot id: F7AN95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8364:LOC116408581
gene id: 8364:LOC116408581
uniprot id: A0A8J1J2G0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC101731116
gene id: 8364:LOC101731116
uniprot id: A0A8J1IZ97
names: Subcellular Location Annotation
messages: Membrane

8364:slc39a1
gene id: 8364:slc39a1
uniprot id: A0A803KIT7
uniprot id: Q28DI8
names: Subcellular Location Annotation
messages: Membrane

8364:LOC101732940
gene id: 8364:LOC101732940
uniprot id: A0A803K8B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

8364:LOC100494130
gene id: 8364:LOC100494130
uniprot id: A0A8J0R7H6
names: Similarity
messages: Belongs to the MHC class I family.

8364:LOC100494223
gene id: 8364:LOC100494223
uniprot id: A0A803JAF7
uniprot id: A0A803JEL4
uniprot id: A0A8J1J570
names: Similarity
messages: Belongs to the S-100 family.

8364:krt12.5
gene id: 8364:krt12.5
uniprot id: B0BMH1
names: Similarity
messages: Belongs to the intermediate filament family.

8364:chchd6
gene id: 8364:chchd6
uniprot id: A0A6I8RWT6
uniprot id: A0A803J3M5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Membrane
messages: Mitochondrion inner membrane

8364:cdh2
gene id: 8364:cdh2
uniprot id: B2GUA1
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane

8364:hoxa6
gene id: 8364:hoxa6
uniprot id: A0A6I8QY84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

8364:bmp8
gene id: 8364:bmp8
uniprot id: A0A803JK50
names: Similarity
messages: Belongs to the TGF-beta family.

8364:dmtn
gene id: 8364:dmtn
uniprot id: A0A8J0SH67
uniprot id: A0A8J0SID4
uniprot id: A0A8J1JAU3
uniprot id: Q5EAL7
names: Subcellular Location Annotation
messages: Cytoplasm

8364:LOC116406808
gene id: 8364:LOC116406808
uniprot id: A0A8J1IS63
names: Subcellular Location Annotation
messages: Membrane

8364:hs3st2
gene id: 8364:hs3st2
uniprot id: A0A5S6N1G7
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8364:slc7a13
gene id: 8364:slc7a13
uniprot id: A0A6I8SE79
names: Subcellular Location Annotation
messages: Membrane

8364:tbxt
gene id: 8364:tbxt
uniprot id: A0A8J0SE23
uniprot id: Q66IH3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8364:ube2b
gene id: 8364:ube2b
uniprot id: Q6DDC8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8364:coro7
gene id: 8364:coro7
uniprot id: A0A6I8QPT0
names: Similarity
messages: Belongs to the WD repeat coronin family.

8364:cnmd
gene id: 8364:cnmd
uniprot id: F7AJQ8
names: Similarity
messages: Belongs to the chondromodulin-1 family.

8364:myof.1
gene id: 8364:myof.1
uniprot id: A0A6I8QNL3
uniprot id: A0A6I8S9W7
uniprot id: A0A7D9NM49
uniprot id: A0A8J0SHI0
uniprot id: A0A8J1JRL8
uniprot id: A0A8J1JRN2
uniprot id: A0A8J1JU27
uniprot id: A0A8J1JVD0
uniprot id: B3DLH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferlin family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: May play a role in membrane regeneration and repair.
messages: Membrane
messages: Nucleus membrane

8364:fam124a
gene id: 8364:fam124a
uniprot id: F7ETC2
uniprot id: Q6DIL6
names: Similarity
messages: Belongs to the FAM124 family.

8364:hsph1
gene id: 8364:hsph1
uniprot id: A0A8J0QI07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm

8364:h3f3b
gene id: 8364:h3f3b
uniprot id: A9JTR4
uniprot id: Q6P823
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Monoubiquitinated by rag1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin. Phosphorylation on Ser-32 (H3S31ph) is specific to regions bordering centromeres in metaphase chromosomes.
messages: Serine ADP-ribosylation constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Specific interaction of trimethylated form at 'Lys-36' (H3.3K36me3) with zmynd11 is mediated by the encapsulation of Ser-32 residue with a composite pocket formed by the tandem bromo-PWWP domains.
messages: Specifically enriched in modifications associated with active chromatin such as methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with zmynd11; when trimethylated at 'Lys-36' (H3.3K36me3).
messages: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

8364:kcnq2
gene id: 8364:kcnq2
uniprot id: A0A6I8SIM6
uniprot id: A0A803JMV6
uniprot id: A0A803K497
uniprot id: A0A8J1IY01
uniprot id: A0A8J1J182
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC105946865
gene id: 8364:LOC105946865
uniprot id: A0A8J0SAL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:aktip
gene id: 8364:aktip
uniprot id: Q28IA3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Lacks the conserved Cys residue necessary for ubiquitin-conjugating enzyme E2 activity.
messages: May function to promote vesicle trafficking and/or fusion. May also regulate apoptosis (By similarity).

8364:naxe
gene id: 8364:naxe
uniprot id: A0A8J0QQE6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: Secreted

8364:mrps2
gene id: 8364:mrps2
uniprot id: Q28D21
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

8364:ift22
gene id: 8364:ift22
uniprot id: Q5M8K8
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

8364:hmgcs1
gene id: 8364:hmgcs1
uniprot id: B0JZH5
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

8364:LOC116406842
gene id: 8364:LOC116406842
uniprot id: A0A8J1IPZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100487954
gene id: 8364:LOC100487954
uniprot id: F6TCR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8364:isl1
gene id: 8364:isl1
uniprot id: A0A8J0PIC3
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC105947969
gene id: 8364:LOC105947969
uniprot id: A0A8J0SJP1
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

8364:osgep
gene id: 8364:osgep
uniprot id: A0A8J0SMH6
uniprot id: Q0V9I9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleus

8364:smg1
gene id: 8364:smg1
uniprot id: A0A6I8QIW8
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

8364:cd99
gene id: 8364:cd99
uniprot id: A0A6I8QVQ9
uniprot id: A0A6I8SM91
uniprot id: A0A803JM26
uniprot id: A0A8J0S8C7
names: Similarity
messages: Belongs to the CD99 family.

8364:lrrc8a
gene id: 8364:lrrc8a
uniprot id: F6WY49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

8364:pex13
gene id: 8364:pex13
uniprot id: F7EUW7
names: Similarity
messages: Belongs to the peroxin-13 family.

8364:adgrl1
gene id: 8364:adgrl1
uniprot id: A0A6I8Q936
uniprot id: A0A6I8QD30
uniprot id: A0A6I8S6D7
uniprot id: A0A8J0S5M6
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100486243
gene id: 8364:LOC100486243
uniprot id: A0A8J0SQB0
names: Subcellular Location Annotation
messages: Membrane

8364:gins2
gene id: 8364:gins2
uniprot id: Q5EB27
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus

8364:sia1
gene id: 8364:sia1
uniprot id: A0A1B4ZDM7
uniprot id: Q28G02
names: Function
names: Subcellular Location Annotation
messages: Essential for Wnt/beta-catenin-mediated formation of the Spemann organizer and for induction of the organizer precursor, the Nieuwkoop center. Acts as a transcriptional activator, cooperating with TGFbeta signals to induce a program of organizer-specific gene expression and to generate an organizer with both head- and trunk-inducing activity. Activates the head organizer gene cer1 by acting synergistically with otx2 and mix-A/mix.1 through the 5'-TAATCT-3' element of the cer1 promoter. Also binds as a complex with lhx1/lim1 and mix-A/mix.1 to the 3x 5'-TAAT-3' element of the cer1 promoter. Required for subsequent dorsoventral axis formation in the embryo, dorsalizing ventral mesoderm and cooperating with t/bra to induce dorsal mesoderm. Also involved in neural induction, inducing the cement gland and neural tissue in overlying ectoderm. Later in development, has the second function of indirectly repressing ventral genes, probably by activating the expression of a transcriptional repressor (By similarity).
messages: Nucleus

8364:phtf2
gene id: 8364:phtf2
uniprot id: A0A6I8QU41
uniprot id: A0A8J0SJU8
uniprot id: A0A8J0SZC6
uniprot id: A0A8J1JE17
names: Subcellular Location Annotation
messages: Membrane

8364:ruvbl1
gene id: 8364:ruvbl1
uniprot id: F6Q5T7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

8364:cldn6.1
gene id: 8364:cldn6.1
uniprot id: Q6PBE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8364:LOC116408033
gene id: 8364:LOC116408033
uniprot id: A8E6F4
names: Subcellular Location Annotation
messages: Secreted

8364:KEG17 p04
gene id: 8364:KEG17_p04
uniprot id: Q5G7I1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion membrane

8364:pank4
gene id: 8364:pank4
uniprot id: A0A8J0QCR3
uniprot id: A0A8J1JS20
uniprot id: B1H3E6
names: Similarity
names: Subunit
messages: Belongs to the type II pantothenate kinase family.
messages: Homodimer. Interacts with PKM.
messages: In the N-terminal section; belongs to the type II pantothenate kinase family.

8364:uxs1
gene id: 8364:uxs1
uniprot id: Q6DF08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
messages: Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.
messages: Golgi stack membrane
messages: Homodimer and homotetramer.

8364:LOC100493356
gene id: 8364:LOC100493356
uniprot id: A0A6I8QGV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Membrane

8364:LOC116409529
gene id: 8364:LOC116409529
uniprot id: A0A8J1JAK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:stab1
gene id: 8364:stab1
uniprot id: A0A8J1JH71
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:amacr
gene id: 8364:amacr
uniprot id: Q68EP6
names: Similarity
messages: Belongs to the CoA-transferase III family.

8364:cd8b
gene id: 8364:cd8b
uniprot id: A0A8J1J2K6
names: Subcellular Location Annotation
messages: Membrane

8364:rrm1
gene id: 8364:rrm1
uniprot id: B1WAW9
uniprot id: F6TKJ2
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

8364:glis1
gene id: 8364:glis1
uniprot id: A0A803JPB2
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

8364:rft1
gene id: 8364:rft1
uniprot id: A0A8J0ST32
uniprot id: Q0D2E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFT1 family.
messages: May be involved in N-linked oligosaccharide assembly.
messages: May be involved in N-linked oligosaccharide assembly. May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane (By similarity).
messages: Membrane

8364:KEG17 p12
gene id: 8364:KEG17_p12
uniprot id: Q5G7I9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

8364:anp32e
gene id: 8364:anp32e
uniprot id: A0A8J0SL76
uniprot id: Q28BK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANP32 family.
messages: Multifunctional protein that is involved in the regulation of many processes.
messages: Nucleus

8364:apeh
gene id: 8364:apeh
uniprot id: A0A6I8QME0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S9C family.
messages: Cytoplasm
messages: Homotetramer.

8364:LOC116410947
gene id: 8364:LOC116410947
uniprot id: A0A8J1JPG6
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC116409550
gene id: 8364:LOC116409550
uniprot id: A0A8J1J895
names: Subcellular Location Annotation
messages: Membrane

8364:LOC108645245
gene id: 8364:LOC108645245
uniprot id: A0A8J1IUC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H3 family.
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus

8364:il20
gene id: 8364:il20
uniprot id: A0A8J0SD44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

8364:cog4
gene id: 8364:cog4
uniprot id: B1WAP4
uniprot id: F6TNZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG4 family.
messages: Golgi apparatus membrane

8364:ell2
gene id: 8364:ell2
uniprot id: F6THI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

8364:tdp1
gene id: 8364:tdp1
uniprot id: A0A8J1ILM2
uniprot id: A0A8J1IPF0
uniprot id: Q28BM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: Nucleus

8364:wnt7b
gene id: 8364:wnt7b
uniprot id: B0JYX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8364:LOC100485356
gene id: 8364:LOC100485356
uniprot id: A0A8J1JHX6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:tlx1
gene id: 8364:tlx1
uniprot id: A0A8J0QSM9
uniprot id: F6TEU6
names: Subcellular Location Annotation
messages: Nucleus

8364:eif2b5
gene id: 8364:eif2b5
uniprot id: A0A8J0SEK8
uniprot id: F6R6Q4
names: Similarity
messages: Belongs to the eIF-2B gamma/epsilon subunits family.

8364:prkab1
gene id: 8364:prkab1
uniprot id: F6T9F9
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

8364:emc2
gene id: 8364:emc2
uniprot id: Q5M7J9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.

8364:pus3
gene id: 8364:pus3
uniprot id: F6ZXE9
uniprot id: Q6P815
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

8364:LOC100487906
gene id: 8364:LOC100487906
uniprot id: F6YU25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

8364:LOC100495870
gene id: 8364:LOC100495870
uniprot id: A0A1B8Y816
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:tmprss2.5
gene id: 8364:tmprss2.5
uniprot id: A0A8J1J3G3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:tcf19
gene id: 8364:tcf19
uniprot id: A0A8J0QT45
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC779885
gene id: 8364:LOC779885
uniprot id: Q0IIS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

8364:nup93
gene id: 8364:nup93
uniprot id: Q6NX12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: Nucleus membrane
messages: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.
messages: nuclear pore complex

8364:itprip
gene id: 8364:itprip
uniprot id: F7CAE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Membrane

8364:pde7b
gene id: 8364:pde7b
uniprot id: A0A6I8Q9N9
uniprot id: A0A8J1JHC1
uniprot id: F6XXE9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8364:ovch1
gene id: 8364:ovch1
uniprot id: A0A6I8RGJ5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC101733298
gene id: 8364:LOC101733298
uniprot id: F7A5K6
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:cndp2
gene id: 8364:cndp2
uniprot id: Q6P358
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

8364:ran
gene id: 8364:ran
uniprot id: Q28FV6
uniprot id: Q6GL85
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Ran family.
messages: Cytoplasm
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
messages: GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis.
messages: Mg(2+) interacts primarily with the phosphate groups of the bound guanine nucleotide.
messages: Monomer. Interacts with rangap1, which promotes ran-mediated GTP hydrolysis. Interacts with kpnb1. Interaction with kpnb1 inhibits rangap1-mediated stimulation of GTPase activity. Interacts with rcc1 which promotes the exchange of ran-bound GDP by GTP. Interaction with kpnb1 inhibits rcc1-mediated exchange of ran-bound GDP by GTP. Interacts (GTP-bound form) with tnpo1; the interaction is direct. Interacts (GTP-bound form) with tnpo3; the interaction is direct. Interacts with kpnb1 and with tnpo1; both inhibit ran GTPase activity. Interacts (via C-terminus) with ranbp1, which alleviates the inhibition of ran GTPase activity. Interacts with rangrf, which promotes the release of bound guanine nucleotide. Rangrf and rcc1 compete for an overlapping binding site on ran. Identified in a complex with kpna2 and cse1l; interaction with ranbp1 mediates dissociation of ran from this complex. Interaction with both ranbp1 and kpna2 promotes dissociation of the complex between ran and kpnb1. Identified in a complex composed of ran, rangap1 and ranbp1. Identified in a complex that contains tnpo1, ran and ranbp1. Identified in a nuclear export complex with xpo1. Interaction with ranbp1 or ranbp2 induces a conformation change in the complex formed by xpo1 and ran that triggers the release of the nuclear export signal of cargo proteins. Component of a nuclear export receptor complex composed of kpnb1, ran, snupn and xpo1 (By similarity).
messages: Nucleus
messages: Nucleus envelope
messages: cytosol

8364:LOC101734834
gene id: 8364:LOC101734834
uniprot id: A0A8J1J313
names: Subcellular Location Annotation
messages: Membrane

8364:ncoa1
gene id: 8364:ncoa1
uniprot id: A0A8J1JHH6
uniprot id: A0A8J1JHI1
uniprot id: A0A8J1JHI5
uniprot id: A0A8J1JJX9
uniprot id: A0A8J1JJY7
uniprot id: A0A8J1JL27
uniprot id: A8WGE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

8364:mfsd14b
gene id: 8364:mfsd14b
uniprot id: Q5M7S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

8364:cpne3
gene id: 8364:cpne3
uniprot id: A0A6I8QKY6
uniprot id: Q66JK5
names: Similarity
messages: Belongs to the copine family.

8364:eif3k
gene id: 8364:eif3k
uniprot id: Q28C65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm
messages: Nucleus

8364:gpr183.2
gene id: 8364:gpr183.2
uniprot id: A0A803JPW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:cmpk1
gene id: 8364:cmpk1
uniprot id: A0A8J0QFY8
uniprot id: A0A8J0QH64
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

8364:atf2
gene id: 8364:atf2
uniprot id: A0A8J0R6J4
uniprot id: A0A8J0T6D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

8364:LOC101734657
gene id: 8364:LOC101734657
uniprot id: A0A8J1J8C7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:inhbb
gene id: 8364:inhbb
uniprot id: A0A803JF31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

8364:LOC100216133
gene id: 8364:LOC100216133
uniprot id: B4F717
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

8364:nes
gene id: 8364:nes
uniprot id: A0A803JEA0
names: Similarity
messages: Belongs to the intermediate filament family.

8364:cyct
gene id: 8364:cyct
uniprot id: A0A8J1IVG0
uniprot id: Q640U4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space

8364:LOC116408576
gene id: 8364:LOC116408576
uniprot id: A0A8J1J2F4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:thbs4
gene id: 8364:thbs4
uniprot id: Q08D10
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC100485649
gene id: 8364:LOC100485649
uniprot id: A0A1B8Y8U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:hif1a
gene id: 8364:hif1a
uniprot id: F6VTE9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:them6
gene id: 8364:them6
uniprot id: B0BLZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THEM6 family.
messages: Secreted

8364:dipk1c
gene id: 8364:dipk1c
uniprot id: F6SP44
names: Similarity
messages: Belongs to the DIPK family.

8364:slc16a13
gene id: 8364:slc16a13
uniprot id: A4IGX9
names: Subcellular Location Annotation
messages: Membrane

8364:cnot10
gene id: 8364:cnot10
uniprot id: A0A6I8Q621
uniprot id: F6QEJ9
uniprot id: Q28FZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT10 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
messages: Cytoplasm
messages: Nucleus

8364:ccnk
gene id: 8364:ccnk
uniprot id: Q0V9U3
names: Similarity
messages: Belongs to the cyclin family.

8364:pnlip
gene id: 8364:pnlip
uniprot id: A0A8J1JS00
uniprot id: A0A8J1JS08
uniprot id: B1H305
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

8364:nol10
gene id: 8364:nol10
uniprot id: Q6NVM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

8364:LOC101735147
gene id: 8364:LOC101735147
uniprot id: A0A8J1JHW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Lysosome

8364:meis1
gene id: 8364:meis1
uniprot id: A0A6I8RCT9
uniprot id: A0A8J0R1V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

8364:LOC116410981
gene id: 8364:LOC116410981
uniprot id: A0A8J1JPQ2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:arg1
gene id: 8364:arg1
uniprot id: Q6DIU5
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.
messages: Homotrimer.

8364:syndig1
gene id: 8364:syndig1
uniprot id: A4IGW9
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8364:fam83d
gene id: 8364:fam83d
uniprot id: A0A803JDT8
names: Similarity
messages: Belongs to the FAM83 family.

8364:hsbp1l1
gene id: 8364:hsbp1l1
uniprot id: A0A8J0SP24
names: Similarity
messages: Belongs to the HSBP1 family.

8364:rfc5
gene id: 8364:rfc5
uniprot id: Q5XGD2
names: Similarity
messages: Belongs to the activator 1 small subunits family.

8364:cnot7
gene id: 8364:cnot7
uniprot id: A0A8J1JLN1
uniprot id: A4II96
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CAF1 family.
messages: Binds 2 divalent metal cations per subunit with RNAase activity being higher in presence of Mn(2+) than of Mg(2+) or Co(2+).
messages: Component of the CCR4-NOT complex.
messages: Cytoplasm
messages: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression.
messages: Nucleus

8364:nr1i3
gene id: 8364:nr1i3
uniprot id: A0A6I8SU65
uniprot id: A0A8J1IP21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

8364:ntrk3
gene id: 8364:ntrk3
uniprot id: A0A8J0QXE9
uniprot id: A0A8J1JB52
uniprot id: A0A8J1JEM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

8364:cyp27b1
gene id: 8364:cyp27b1
uniprot id: F7AM55
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:rps26
gene id: 8364:rps26
uniprot id: Q6DDC9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

8364:ptx4
gene id: 8364:ptx4
uniprot id: A0A6I8RTI6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:wnt7c
gene id: 8364:wnt7c
uniprot id: A0A6I8QCH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8364:LOC116407572
gene id: 8364:LOC116407572
uniprot id: A0A8J1ITM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:LOC100495467
gene id: 8364:LOC100495467
uniprot id: A0A8J1IQU4
uniprot id: A0A8J1IQV6
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8364:nampt
gene id: 8364:nampt
uniprot id: Q5M7L4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPRTase family.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Secreted

8364:arhgef6
gene id: 8364:arhgef6
uniprot id: A0A6I8Q766
uniprot id: A0A6I8QWY3
uniprot id: A0A8J0SUG7
uniprot id: A0A8J1IPB5
names: Subcellular Location Annotation
messages: lamellipodium

8364:gtf2ird1
gene id: 8364:gtf2ird1
uniprot id: A0A803JP11
uniprot id: A0A8J0QWB5
uniprot id: A0A8J0SDM7
uniprot id: A0A8J0SRL7
names: Subcellular Location Annotation
messages: Nucleus

8364:gucy2c
gene id: 8364:gucy2c
uniprot id: F7BYS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

8364:LOC116407587
gene id: 8364:LOC116407587
uniprot id: Q28D68
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:gpd2
gene id: 8364:gpd2
uniprot id: A8KBC3
names: Function
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device.

8364:lama2
gene id: 8364:lama2
uniprot id: A0A8J0SU16
uniprot id: A0A8J0T116
uniprot id: A0A8J0T326
uniprot id: A0A8J0T3H2
uniprot id: A0A8J0T4A5
uniprot id: A0A8J1JJ05
uniprot id: A0A8J1JJ06
uniprot id: A0A8J1JLF4
uniprot id: A0A8J1JML5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

8364:c1orf109
gene id: 8364:c1orf109
uniprot id: Q28I03
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles.
messages: Nucleus

8364:faf2
gene id: 8364:faf2
uniprot id: Q28BP9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Lipid droplet
messages: Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Involved in inhibition of lipid droplet degradation. Involved in stress granule disassembly.

8364:ndrg2
gene id: 8364:ndrg2
uniprot id: A0A8J0SK36
uniprot id: Q66KM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation (By similarity).
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.
messages: Cytoplasm

8364:ppp1r16a
gene id: 8364:ppp1r16a
uniprot id: Q0V9P4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:lca5
gene id: 8364:lca5
uniprot id: A0A6I8PV29
names: Similarity
messages: Belongs to the LCA5 family.

8364:LOC100486720
gene id: 8364:LOC100486720
uniprot id: A0A1B8XZW2
uniprot id: Q28D37
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by rag1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:myo18b
gene id: 8364:myo18b
uniprot id: A0A8J0SXQ3
uniprot id: A0A8J0T0W0
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:celsr3
gene id: 8364:celsr3
uniprot id: A0A6I8S095
uniprot id: A0A6I8S9W5
uniprot id: A0A8J1JJ43
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor that may have an important role in cell/cell signaling during nervous system formation.

8364:chrdl1
gene id: 8364:chrdl1
uniprot id: A0A803JV54
uniprot id: B1H2T8
names: Subcellular Location Annotation
messages: Secreted

8364:rps7
gene id: 8364:rps7
uniprot id: A0A8J0SNB6
uniprot id: A9JSD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eS7 family.
messages: centrosome

8364:oprk1
gene id: 8364:oprk1
uniprot id: A0A8J0QGA7
uniprot id: F7A0F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:sec23b
gene id: 8364:sec23b
uniprot id: Q28DM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

8364:tmem63a
gene id: 8364:tmem63a
uniprot id: Q0V9Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

8364:acadvl
gene id: 8364:acadvl
uniprot id: A0A803JR71
uniprot id: A0A8J1JFP4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

8364:pla2g1b
gene id: 8364:pla2g1b
uniprot id: B1H311
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

8364:mrps18b
gene id: 8364:mrps18b
uniprot id: A0A8J0QW72
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.

8364:mtr
gene id: 8364:mtr
uniprot id: A0A6I8QLS5
uniprot id: A0A8J1JM72
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.
messages: Cytoplasm
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

8364:acy3
gene id: 8364:acy3
uniprot id: A0A8J1J5E3
uniprot id: Q5BJ91
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the AspA/AstE family. Aspartoacylase subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Plays an important role in deacetylating mercapturic acids in kidney proximal tubules.

8364:sult1b1
gene id: 8364:sult1b1
uniprot id: A4IH93
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8364:LOC101734540
gene id: 8364:LOC101734540
uniprot id: A0A8J0R7X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:sox14
gene id: 8364:sox14
uniprot id: A4QNG3
names: Function
names: Subcellular Location Annotation
messages: Acts as a negative regulator of transcription. May function as a switch in neuronal development (By similarity).
messages: Nucleus

8364:LOC105945182
gene id: 8364:LOC105945182
uniprot id: A0A8J1JJ51
names: Subcellular Location Annotation
messages: Nucleus

8364:spice1
gene id: 8364:spice1
uniprot id: A0A6I8PWW9
uniprot id: A0A8J0S766
uniprot id: A0A8J0SDT3
uniprot id: A0A8J0SEU5
uniprot id: B2GUE3
names: Subcellular Location Annotation
messages: centriole
messages: spindle

8364:myoz2
gene id: 8364:myoz2
uniprot id: A0A803JLQ6
uniprot id: A0A803KL58
uniprot id: A0A8J0SC42
uniprot id: A0A8J0SKH7
names: Similarity
messages: Belongs to the myozenin family.

8364:dusp12
gene id: 8364:dusp12
uniprot id: Q28I15
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

8364:mbd4
gene id: 8364:mbd4
uniprot id: Q28HB5
names: Subcellular Location Annotation
messages: Nucleus

8364:rrm2.1
gene id: 8364:rrm2.1
uniprot id: A0A6I8PRV0
uniprot id: F6VJ70
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

8364:ntn4
gene id: 8364:ntn4
uniprot id: A0A8J1JA78
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC100488881
gene id: 8364:LOC100488881
uniprot id: A0A6I8PYY9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPCAM family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:abo.2
gene id: 8364:abo.2
uniprot id: Q0IHL9
uniprot id: Q28GQ1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Membrane

8364:edn2
gene id: 8364:edn2
uniprot id: A0A803JKX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

8364:ddost
gene id: 8364:ddost
uniprot id: B1H3C9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDOST 48 kDa subunit family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (By similarity). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (By similarity).

8364:wee1
gene id: 8364:wee1
uniprot id: A0A8J1JFB4
uniprot id: A0A8J1JGD1
uniprot id: B1H303
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Binds 2 magnesium ions per subunit.
messages: Nucleus

8364:LOC100485201
gene id: 8364:LOC100485201
uniprot id: F6PYC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

8364:LOC105945483
gene id: 8364:LOC105945483
uniprot id: A0A8J1JFG0
uniprot id: F7BIJ8
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:kcnk5
gene id: 8364:kcnk5
uniprot id: A0A803JN18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

8364:dclk3
gene id: 8364:dclk3
uniprot id: A0A8J0SUT6
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

8364:trmt13
gene id: 8364:trmt13
uniprot id: A0A803K9I8
uniprot id: F7EU89
names: Function
names: Similarity
messages: Belongs to the methyltransferase TRM13 family.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

8364:h2aj
gene id: 8364:h2aj
uniprot id: Q6DK82
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:grm1
gene id: 8364:grm1
uniprot id: A0A8J1JNC4
uniprot id: F6WJ54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

8364:scn4a
gene id: 8364:scn4a
uniprot id: A0A6I8RCN6
uniprot id: A0A8J0SQ73
uniprot id: A0A8J1IXV0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

8364:chd2
gene id: 8364:chd2
uniprot id: A0A6I8Q0Q2
uniprot id: A0A8J0T1Z3
names: Subcellular Location Annotation
messages: Nucleus

8364:tnpo1
gene id: 8364:tnpo1
uniprot id: A0A6I8SEZ6
uniprot id: A0A8J0QQ75
names: Subcellular Location Annotation
messages: Cytoplasm

8364:gprin3
gene id: 8364:gprin3
uniprot id: A0A6I8RWM7
names: Function
messages: May be involved in neurite outgrowth.

8364:acsl1
gene id: 8364:acsl1
uniprot id: A0A6I8R975
uniprot id: Q6DF45
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.

8364:LOC116408580
gene id: 8364:LOC116408580
uniprot id: A0A8J1J2G8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:slc6a4
gene id: 8364:slc6a4
uniprot id: A0A6I8RCX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Endosome membrane
messages: Membrane
messages: Synapse
messages: focal adhesion
messages: neuron projection

8364:trmt10a
gene id: 8364:trmt10a
uniprot id: Q66JJ4
names: Function
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
messages: S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs.

8364:pkm
gene id: 8364:pkm
uniprot id: F7B2Y6
uniprot id: Q28HE2
names: Similarity
messages: Belongs to the pyruvate kinase family.

8364:ventx2.2
gene id: 8364:ventx2.2
uniprot id: A0A6I8PMB5
names: Subcellular Location Annotation
messages: Nucleus

8364:cryga.1
gene id: 8364:cryga.1
uniprot id: A0A803K1L9
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:rspo3
gene id: 8364:rspo3
uniprot id: Q5UE89
names: Similarity
messages: Belongs to the R-spondin family.

8364:LOC116410389
gene id: 8364:LOC116410389
uniprot id: A0A8J1JFG9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:orc6
gene id: 8364:orc6
uniprot id: Q28I20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC6 family.
messages: Nucleus

8364:LOC116407727
gene id: 8364:LOC116407727
uniprot id: A0A8J1IV54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8364:vhl
gene id: 8364:vhl
uniprot id: A9ULN6
names: Similarity
messages: Belongs to the VHL family.

8364:gabrb1
gene id: 8364:gabrb1
uniprot id: A0A803KBP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:sfxn3
gene id: 8364:sfxn3
uniprot id: B5DEV1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

8364:rrn3
gene id: 8364:rrn3
uniprot id: A0A6I8QER1
names: Similarity
messages: Belongs to the RRN3 family.

8364:sdr16c5
gene id: 8364:sdr16c5
uniprot id: A0A803KGF7
uniprot id: F7BZ60
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8364:kif2c
gene id: 8364:kif2c
uniprot id: A0A8J1JGT3
uniprot id: Q6DEY2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8364:ssrp1
gene id: 8364:ssrp1
uniprot id: A0A6I8RRM8
uniprot id: Q6GLF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Nucleus

8364:LOC100496868
gene id: 8364:LOC100496868
uniprot id: A0A803JVY5
names: Similarity
messages: Belongs to the cyclin family.

8364:sting1
gene id: 8364:sting1
uniprot id: A0A8J1J6F3
uniprot id: A8E5V9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STING family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Homodimer; forms a homodimer in absence of cyclic nucleotide (c-di-GMP or cGAMP). Homotetramer; in presence of cyclic nucleotide (c-di-GMP or cGAMP), forms tetramers and higher-order oligomers through side-by-side packing.
messages: In absence of cGAMP, the transmembrane and cytoplasmic regions interact to form an integrated, domain-swapped dimeric assembly (By similarity). In absence of cyclic nucleotide (c-di-GMP or cGAMP), the protein is autoinhibited by an intramolecular interaction between the cyclic dinucleotide-binding domain (CBD) and the C-terminal tail (CTT) (By similarity). Following cGAMP-binding, the cyclic dinucleotide-binding domain (CBD) is closed, leading to a 180 degrees rotation of the CBD domain relative to the transmembrane domain. This rotation is coupled to a conformational change in a loop on the side of the CBD dimer, which leads to the formation of the STING1 tetramer and higher-order oligomers through side-by-side packing (By similarity).
messages: Sensor of cytosolic DNA from bacteria and viruses that promotes autophagy. Acts by recognizing and binding cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA in the cytosol (PubMed:26300263, PubMed:30842662). Following cGAMP-binding, promotes the formation of autophagosomes, leading to target cytosolic DNA for degradation by the lysosome (PubMed:30842662). Exhibits guanine base-specific ligand recognition. Binds 3'-3'linked cGAMP, 2'-3' linked cGAMP and 3'-3' linked c-di-GMP with much greater affinity as compared to 3'-3' linked c-di-AMP (PubMed:26300263). Lacks the C-terminal tail (CTT) found in other vertebrate orthologs which is essential for interferon signaling (PubMed:26300263).
messages: The N-terminal domain interacts with glycerophospholipids and phospholipids.
messages: autophagosome membrane
messages: perinuclear region

8364:tubb3
gene id: 8364:tubb3
uniprot id: L7N3Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

8364:slc25a32
gene id: 8364:slc25a32
uniprot id: A0A8J1JN35
uniprot id: A9ULD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8364:cox7c
gene id: 8364:cox7c
uniprot id: A0A8J0QEP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

8364:fdxr
gene id: 8364:fdxr
uniprot id: A0A803KGG1
uniprot id: F6XUJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferredoxin--NADP reductase type 1 family.
messages: Mitochondrion
messages: Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.

8364:ptx
gene id: 8364:ptx
uniprot id: A0A8J0QFD9
uniprot id: A9JTU7
uniprot id: A9UMU2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:cnih1
gene id: 8364:cnih1
uniprot id: Q66JD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

8364:atp2b2
gene id: 8364:atp2b2
uniprot id: A0A6I8R566
uniprot id: A0A6I8RA99
uniprot id: A0A6I8REL0
uniprot id: A0A8J0QYR2
uniprot id: A0A8J0R0U6
uniprot id: A0A8J0R2Y5
uniprot id: A0A8J0R3L7
uniprot id: A0A8J1JGG5
uniprot id: A0A8J1JGG7
uniprot id: A0A8J1JIW5
uniprot id: A0A8J1JJZ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:gtdc1
gene id: 8364:gtdc1
uniprot id: A0A8J0SVG4
uniprot id: Q66K99
names: Similarity
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

8364:LOC100495802
gene id: 8364:LOC100495802
uniprot id: A0A8J1IQN0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:LOC100492865
gene id: 8364:LOC100492865
uniprot id: A0A8J0T284
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

8364:set
gene id: 8364:set
uniprot id: F6RJH1
uniprot id: Q28FE9
uniprot id: Q6P858
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

8364:ikbke
gene id: 8364:ikbke
uniprot id: A0A6I8Q3J4
uniprot id: A0A8J1J7U6
names: Subcellular Location Annotation
messages: Cytoplasm

8364:cops7b
gene id: 8364:cops7b
uniprot id: F7ED99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

8364:mocs2
gene id: 8364:mocs2
uniprot id: A0A8J1IZD0
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.
messages: Belongs to the MoaD family. MOCS2A subfamily.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
messages: This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2B).
messages: cytosol

8364:cebpg
gene id: 8364:cebpg
uniprot id: Q28H70
names: Similarity
messages: Belongs to the bZIP family. C/EBP subfamily.

8364:isoc1
gene id: 8364:isoc1
uniprot id: A0A5S6LA88
uniprot id: A0A803J4B6
uniprot id: A0A803JUD3
uniprot id: Q0IHU5
names: Similarity
messages: Belongs to the isochorismatase family.

8364:tbc1d2b
gene id: 8364:tbc1d2b
uniprot id: Q28CB1
names: Function
names: Subcellular Location Annotation
messages: Early endosome
messages: GTPase-activating protein that plays a role in the early steps of endocytosis.

8364:pfn2
gene id: 8364:pfn2
uniprot id: B3DLT3
names: Similarity
messages: Belongs to the profilin family.

8364:gsk3b
gene id: 8364:gsk3b
uniprot id: A0A803J2W8
uniprot id: A0A8J0T0Z2
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

8364:tor1a
gene id: 8364:tor1a
uniprot id: Q28CP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

8364:avpr1b
gene id: 8364:avpr1b
uniprot id: F7EHY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane

8364:rem2
gene id: 8364:rem2
uniprot id: F6WHE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. RGK family.
messages: Cell membrane

8364:notum
gene id: 8364:notum
uniprot id: A0A8J0QC63
uniprot id: B1H0Y7
names: Similarity
messages: Belongs to the pectinacetylesterase family. Notum subfamily.

8364:fzd10
gene id: 8364:fzd10
uniprot id: Q6GL20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Membrane

8364:cycs
gene id: 8364:cycs
uniprot id: Q6PBF4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).
messages: Mitochondrion intermembrane space

8364:LOC100496844
gene id: 8364:LOC100496844
uniprot id: A0A6I8QCI4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:gla
gene id: 8364:gla
uniprot id: F6VA94
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

8364:rassf3
gene id: 8364:rassf3
uniprot id: A0A6I8RJP6
names: Subcellular Location Annotation
messages: cytoskeleton

8364:pfas
gene id: 8364:pfas
uniprot id: A0A8J0QCQ7
uniprot id: A0A8J0SN30
uniprot id: K9J888
names: Similarity
messages: In the N-terminal section; belongs to the FGAMS family.

8364:ddx51
gene id: 8364:ddx51
uniprot id: A0A7D9NKV1
uniprot id: A0A8J0QZ88
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

8364:men1
gene id: 8364:men1
uniprot id: A0A8J0PHM0
names: Subcellular Location Annotation
messages: Nucleus

8364:msmp
gene id: 8364:msmp
uniprot id: A0A803J9A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

8364:slc22a15.1
gene id: 8364:slc22a15.1
uniprot id: Q6DFR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Membrane
messages: Probably transports organic cations.

8364:LOC105948498
gene id: 8364:LOC105948498
uniprot id: A0A6I8RJS2
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8364:tenm1
gene id: 8364:tenm1
uniprot id: A0A6I8QJV4
uniprot id: A0A6I8QSZ6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:c8orf33
gene id: 8364:c8orf33
uniprot id: F6T8W8
names: Similarity
messages: Belongs to the UPF0488 family.

8364:LOC116408378
gene id: 8364:LOC116408378
uniprot id: A0A8J1IZI6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC100145782
gene id: 8364:LOC100145782
uniprot id: B1WBH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

8364:LOC116408370
gene id: 8364:LOC116408370
uniprot id: A0A8J1IZH2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:cebpa
gene id: 8364:cebpa
uniprot id: Q5XHA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

8364:LOC116410243
gene id: 8364:LOC116410243
uniprot id: A0A8J1JEL5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:mettl4
gene id: 8364:mettl4
uniprot id: A0A6I8S5C5
names: Similarity
messages: Belongs to the MT-A70-like family.

8364:lamp1
gene id: 8364:lamp1
uniprot id: A0A6I8S004
uniprot id: B5DFQ2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

8364:LOC101733830
gene id: 8364:LOC101733830
uniprot id: A0A6I8QBF1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:MGC107969
gene id: 8364:MGC107969
uniprot id: Q5FVZ4
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:tsg101
gene id: 8364:tsg101
uniprot id: A0A8J1JD66
uniprot id: Q6P2Z8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.

8364:LOC100486856
gene id: 8364:LOC100486856
uniprot id: A0A8J0QU91
uniprot id: A0A8J1JY59
uniprot id: F7BIV1
names: Similarity
messages: Belongs to the NXPE family.

8364:timm50
gene id: 8364:timm50
uniprot id: B0BMA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM50 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Mitochondrion inner membrane

8364:zbtb8a.2
gene id: 8364:zbtb8a.2
uniprot id: Q6P882
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

8364:gxylt2
gene id: 8364:gxylt2
uniprot id: A0A8J0QS41
names: Subcellular Location Annotation
messages: Membrane

8364:dpy30
gene id: 8364:dpy30
uniprot id: Q640A0
names: Similarity
messages: Belongs to the dpy-30 family.

8364:mrpl24
gene id: 8364:mrpl24
uniprot id: A0A8J0PDD6
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

8364:onecut1.2
gene id: 8364:onecut1.2
uniprot id: A0A6I8QTC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

8364:smad4.2
gene id: 8364:smad4.2
uniprot id: A0A8J1IQ47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

8364:kcnt2l
gene id: 8364:kcnt2l
uniprot id: A0A6I8QLN9
uniprot id: A0A8J0SC64
uniprot id: A0A8J1JBL0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:cwf19l2
gene id: 8364:cwf19l2
uniprot id: F6R2H1
uniprot id: Q28C44
names: Similarity
messages: Belongs to the CWF19 family.

8364:LOC100495578
gene id: 8364:LOC100495578
uniprot id: Q28J31
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:igfbp2
gene id: 8364:igfbp2
uniprot id: A4IIA2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity).
messages: Interacts with igf1 and igf2.
messages: Secreted

8364:mc3r
gene id: 8364:mc3r
uniprot id: A0A803J8I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.

8364:anp32a
gene id: 8364:anp32a
uniprot id: Q28CW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANP32 family.
messages: Multifunctional protein that is involved in the regulation of many processes.
messages: Nucleus

8364:st7
gene id: 8364:st7
uniprot id: A0A6I8Q5I1
uniprot id: A0A8J0SHD9
uniprot id: Q28ER5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

8364:vip
gene id: 8364:vip
uniprot id: A0A6I8PKA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

8364:nop56
gene id: 8364:nop56
uniprot id: A0A8J0QFH3
uniprot id: Q28GZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

8364:dzip1l
gene id: 8364:dzip1l
uniprot id: A0A6I8Q314
uniprot id: F7D831
uniprot id: Q08D43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DZIP C2H2-type zinc-finger protein family.
messages: cilium basal body

8364:atp8b3
gene id: 8364:atp8b3
uniprot id: F6UXA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

8364:ppp1r9b
gene id: 8364:ppp1r9b
uniprot id: A0A6I8RQQ3
names: Subcellular Location Annotation
messages: cytoskeleton

8364:LOC116410791
gene id: 8364:LOC116410791
uniprot id: B5DDY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:LOC108644479
gene id: 8364:LOC108644479
uniprot id: A0A8J1IRE6
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:LOC100498074
gene id: 8364:LOC100498074
uniprot id: A0A8J1IXM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIEZO (TC 1.A.75) family.
messages: Membrane

8364:cldn7
gene id: 8364:cldn7
uniprot id: A0A803JZ29
uniprot id: Q6P8G6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8364:LOC116410873
gene id: 8364:LOC116410873
uniprot id: A0A8J1JJQ6
names: Similarity
messages: Belongs to the peptidase C2 family.

8364:pms2
gene id: 8364:pms2
uniprot id: A0A7D9NKB2
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

8364:bckdk
gene id: 8364:bckdk
uniprot id: A0A6I8Q683
uniprot id: A0A8J0SD13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

8364:LOC100492966
gene id: 8364:LOC100492966
uniprot id: A0A8J0QWG7
names: Subcellular Location Annotation
messages: Secreted

8364:gcsh
gene id: 8364:gcsh
uniprot id: Q63ZZ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

8364:stoml3
gene id: 8364:stoml3
uniprot id: Q6P362
names: Similarity
messages: Belongs to the band 7/mec-2 family.

8364:kcnk9
gene id: 8364:kcnk9
uniprot id: A0A6I8RBB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane
messages: pH-dependent, voltage-insensitive, background potassium channel protein.

8364:tpm4
gene id: 8364:tpm4
uniprot id: A0A8J0SLI4
uniprot id: A0A8J0SMY9
uniprot id: A0A8J0SP68
uniprot id: Q28GF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

8364:pard6g
gene id: 8364:pard6g
uniprot id: Q28DJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

8364:LOC116406456
gene id: 8364:LOC116406456
uniprot id: A0A8J0QRJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

8364:LOC100490663
gene id: 8364:LOC100490663
uniprot id: A0A6I8QJD3
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC100491384
gene id: 8364:LOC100491384
uniprot id: A0A1B8Y758
uniprot id: A0A1B8Y792
uniprot id: A0A8J1IQQ6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:ube2i
gene id: 8364:ube2i
uniprot id: Q28CQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation.
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Forms a tight complex with rangap1 and ranbp2. Interacts with sox9 and sox10 (By similarity).
messages: Nucleus

8364:gsg1lr
gene id: 8364:gsg1lr
uniprot id: A4IIV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As a component of the AMPAR complex, modifies AMPA receptor (AMPAR) gating.
messages: Belongs to the GSG1 family.
messages: Cell membrane
messages: Component of the AMPAR complex.
messages: Synapse

8364:acss3
gene id: 8364:acss3
uniprot id: A0A6I8R1C2
uniprot id: A0A8J1JDN3
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

8364:LOC100485344
gene id: 8364:LOC100485344
uniprot id: A0A8J1IN71
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer or homodimer.

8364:glyr1
gene id: 8364:glyr1
uniprot id: Q562D5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HIBADH-related family. NP60 subfamily.
messages: Chromosome
messages: Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression. Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation. Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA. Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes.
messages: Homotetramere. Binds to mononucleosomes.
messages: In the dehydrogenase domain, the conserved NAD(P)H-binding sites and sequence similarity to plant dehydrogenases suggest that this protein may have oxidoreductase activity. However, since the active site is not conserved, the dehydrogenase domain seems to serve as a catalytically inert oligomerization module.
messages: Nucleus
messages: The A.T hook DNA-binding domain is required for the interaction with MAPK14.
messages: The PWWP domain is a H3 reader and strongly binds DNA.

8364:tmod1
gene id: 8364:tmod1
uniprot id: F6XY38
uniprot id: F7AAF0
names: Subcellular Location Annotation
messages: cytoskeleton

8364:soga3
gene id: 8364:soga3
uniprot id: A0A8J0SPJ9
uniprot id: A0A8J1JJ67
uniprot id: A0A8J1JJ71
names: Similarity
messages: Belongs to the SOGA family.

8364:ppm1e
gene id: 8364:ppm1e
uniprot id: F6YNL0
names: Similarity
messages: Belongs to the PP2C family.

8364:nudt2
gene id: 8364:nudt2
uniprot id: Q28GY0
uniprot id: Q6DIN4
names: Similarity
messages: Belongs to the Nudix hydrolase family.

8364:alx4
gene id: 8364:alx4
uniprot id: F6Q1D5
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC101732289
gene id: 8364:LOC101732289
uniprot id: A0A8J1J1Y9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:tnf
gene id: 8364:tnf
uniprot id: F6VTQ3
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8364:slc26a2
gene id: 8364:slc26a2
uniprot id: A0A803K5I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions. The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange. Essential for chondrocyte proliferation, differentiation and cell size expansion.

8364:cd248
gene id: 8364:cd248
uniprot id: A0A803KD80
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:usp22
gene id: 8364:usp22
uniprot id: A0A803J426
uniprot id: A0A8J0SN42
names: Similarity
messages: Belongs to the peptidase C19 family.

8364:rbm42
gene id: 8364:rbm42
uniprot id: A0A1B8Y9Q2
uniprot id: A0A8J0SS81
uniprot id: Q66KL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM RBM42 family.
messages: Cytoplasm
messages: May bind RNA.
messages: Nucleus

8364:gbe1
gene id: 8364:gbe1
uniprot id: F6ZJE3
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

8364:taf6
gene id: 8364:taf6
uniprot id: A0A8J1JBX5
uniprot id: A0A8J1JBX7
uniprot id: A0A8J1JEC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

8364:th
gene id: 8364:th
uniprot id: F6QRF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
messages: axon
messages: perinuclear region

8364:grk3
gene id: 8364:grk3
uniprot id: A0A6I8S283
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

8364:itga8
gene id: 8364:itga8
uniprot id: A0A6I8QRY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

8364:nif
gene id: 8364:nif
uniprot id: F7DGZ7
names: Similarity
messages: Belongs to the intermediate filament family.

8364:slc17a6
gene id: 8364:slc17a6
uniprot id: A0A1B8Y3J5
names: Subcellular Location Annotation
messages: Membrane

8364:lyplal1
gene id: 8364:lyplal1
uniprot id: Q5RJU7
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

8364:LOC100486030
gene id: 8364:LOC100486030
uniprot id: A0A8J0QMJ9
names: Subcellular Location Annotation
messages: Membrane

8364:LOC101732808
gene id: 8364:LOC101732808
uniprot id: A0A803KE71
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily.
messages: Cell membrane
messages: Membrane

8364:pfn1
gene id: 8364:pfn1
uniprot id: B3DLX0
names: Similarity
messages: Belongs to the profilin family.

8364:pik3cg
gene id: 8364:pik3cg
uniprot id: A0A8J0S934
uniprot id: B2GU76
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

8364:LOC100489518
gene id: 8364:LOC100489518
uniprot id: A0A8J0QR48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

8364:tm4sf5
gene id: 8364:tm4sf5
uniprot id: F6RRT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

8364:scnn1d
gene id: 8364:scnn1d
uniprot id: F6VMZ3
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Membrane
messages: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.

8364:lhpp
gene id: 8364:lhpp
uniprot id: A0A803K6V7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

8364:nprl3
gene id: 8364:nprl3
uniprot id: A0A6I8SSI7
uniprot id: A4IHF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.
messages: Belongs to the NPR3 family.
messages: Lysosome

8364:map4k1
gene id: 8364:map4k1
uniprot id: A0A8J1IQI5
uniprot id: A0A8J1ISY1
uniprot id: F7DD19
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

8364:snrpc
gene id: 8364:snrpc
uniprot id: B0JYS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins snrpb, snrpd1, snrpd2, snrpd3, snrpe, snrpf and snrpg that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins snrnp70/U1-70K, snrpa/U1-A and snrpc/U1-C. snrpc/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus

8364:LOC116406536
gene id: 8364:LOC116406536
uniprot id: A0A8J1ILY2
names: Similarity
messages: Belongs to the cyclin family.

8364:rhbdf2
gene id: 8364:rhbdf2
uniprot id: A0JPA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.

8364:hoxc5
gene id: 8364:hoxc5
uniprot id: F7BDW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

8364:psmd9
gene id: 8364:psmd9
uniprot id: Q28HW8
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

8364:cstf2
gene id: 8364:cstf2
uniprot id: A0A6I8Q2U4
uniprot id: B3DL52
uniprot id: F7AMG7
uniprot id: F7AMH6
names: Subcellular Location Annotation
messages: Nucleus

8364:blmh
gene id: 8364:blmh
uniprot id: Q6GL32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm

8364:LOC101730283
gene id: 8364:LOC101730283
uniprot id: A0A8J0R121
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

8364:LOC116406440
gene id: 8364:LOC116406440
uniprot id: A0A8J1JUG3
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC101735119
gene id: 8364:LOC101735119
uniprot id: A0A6I8S0I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:cdca5
gene id: 8364:cdca5
uniprot id: F6Z346
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

8364:tgfb1
gene id: 8364:tgfb1
uniprot id: F6U272
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
messages: extracellular matrix

8364:col4a6
gene id: 8364:col4a6
uniprot id: A0A6I8RXV9
uniprot id: A0A803JRW2
uniprot id: A0A8J1ITN6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

8364:fezf1
gene id: 8364:fezf1
uniprot id: Q0P4W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Transcription repressor. Involved in the development of the forebrain region (By similarity).

8364:LOC105947167
gene id: 8364:LOC105947167
uniprot id: A0A8J1JET0
names: Subcellular Location Annotation
messages: Nucleus

8364:stambpl1
gene id: 8364:stambpl1
uniprot id: A0A803K9W9
uniprot id: Q6P841
names: Similarity
messages: Belongs to the peptidase M67C family.

8364:LOC105945848
gene id: 8364:LOC105945848
uniprot id: A0A8J0SAN8
names: Similarity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.

8364:LOC100489493
gene id: 8364:LOC100489493
uniprot id: A0A803K6Q8
names: Subcellular Location Annotation
messages: Membrane

8364:cfb
gene id: 8364:cfb
uniprot id: A0A6I8S693
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:LOC100496440
gene id: 8364:LOC100496440
uniprot id: B0JZ06
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:42Sp50
gene id: 8364:42Sp50
uniprot id: Q5I0C1
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

8364:prickle2
gene id: 8364:prickle2
uniprot id: A0A8J0SMH5
uniprot id: F6U3C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prickle / espinas / testin family.
messages: Cell membrane
messages: Membrane

8364:rspo2
gene id: 8364:rspo2
uniprot id: Q5M7L6
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway (By similarity). Activates neural markers and promotes muscle formation. Overexpression blocks activin, nodal and BMP4 signaling, suggesting that it may negatively regulate the TGF-beta pathway (By similarity). During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form (PubMed:29769720).
messages: Belongs to the R-spondin family.
messages: Binds heparin.
messages: Mutant animals exhibit marked forelimb and hindlimb amelia.
messages: Secreted
messages: The FU repeat is required for activation and stabilization of beta-catenin.

8364:LOC734122
gene id: 8364:LOC734122
uniprot id: Q1L0I6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:dph1
gene id: 8364:dph1
uniprot id: A0A6I8RFC6
uniprot id: B5DE05
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.

8364:myct1
gene id: 8364:myct1
uniprot id: Q08D18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYCT1 family.
messages: May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator.
messages: Nucleus

8364:LOC100490298
gene id: 8364:LOC100490298
uniprot id: A0A6I8R6D2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8364:LOC100491227
gene id: 8364:LOC100491227
uniprot id: F7CZV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: synaptosome

8364:tmem14a
gene id: 8364:tmem14a
uniprot id: F6YYA8
names: Similarity
messages: Belongs to the TMEM14 family.

8364:LOC100491504
gene id: 8364:LOC100491504
uniprot id: A0A803K8E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

8364:hnrnpr
gene id: 8364:hnrnpr
uniprot id: A0A8J0QQ94
uniprot id: A0A8J0QW42
names: Subcellular Location Annotation
messages: Cytoplasm

8364:tsnax
gene id: 8364:tsnax
uniprot id: Q6DIG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the translin family.
messages: Nucleus

8364:cmbl
gene id: 8364:cmbl
uniprot id: Q6P7K0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: Cysteine hydrolase.
messages: cytosol

8364:spire2
gene id: 8364:spire2
uniprot id: A0A8J0R2L6
uniprot id: F6PTD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spire family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytoskeleton

8364:patj
gene id: 8364:patj
uniprot id: A0A6I8Q3F8
uniprot id: A0A6I8SLE6
uniprot id: A0A8J0SJE2
uniprot id: A0A8J0SKV2
uniprot id: A0A8J0SM79
uniprot id: A0A8J0T2W4
names: Subcellular Location Annotation
messages: tight junction

8364:trhr
gene id: 8364:trhr
uniprot id: A0A7D9NL80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

8364:cux2
gene id: 8364:cux2
uniprot id: A0A8J0QBY7
uniprot id: A0A8J0QGS6
uniprot id: B5DE16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

8364:spg7
gene id: 8364:spg7
uniprot id: A0A6I8QJN1
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

8364:ppp1r3c.2
gene id: 8364:ppp1r3c.2
uniprot id: Q6GL23
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown (By similarity).
messages: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity (By similarity).
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase, glycogen synthase and phosphorylase kinase.

8364:brpf3
gene id: 8364:brpf3
uniprot id: A0A8J1J271
uniprot id: B5DDZ6
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100492329
gene id: 8364:LOC100492329
uniprot id: A0A8J1JJH4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:or52p1l100487911
gene id: 8364:or52p1l100487911
uniprot id: A0A803J2C5
names: Subcellular Location Annotation
messages: Membrane

8364:hpse2
gene id: 8364:hpse2
uniprot id: A0A803K3N9
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

8364:gpr137c
gene id: 8364:gpr137c
uniprot id: B0JZG6
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

8364:ercc4
gene id: 8364:ercc4
uniprot id: A0A8J0QMY5
uniprot id: A0A8J1IW79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPF family.
messages: Nucleus

8364:nrcam
gene id: 8364:nrcam
uniprot id: A0A6I8PUJ3
uniprot id: A0A6I8S0X0
uniprot id: A0A6I8SU62
uniprot id: A0A8J0S958
uniprot id: A0A8J0SF14
uniprot id: A0A8J0SHX8
uniprot id: A0A8J0SHY4
uniprot id: A0A8J0SRZ0
uniprot id: A0A8J1J6U3
uniprot id: A0A8J1J6U4
uniprot id: A0A8J1J6U5
uniprot id: A0A8J1J6U9
uniprot id: A0A8J1J992
uniprot id: A0A8J1J997
uniprot id: A0A8J1JAA5
uniprot id: A0A8J1JAA9
uniprot id: B5DE72
names: Similarity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

8364:galnt12
gene id: 8364:galnt12
uniprot id: F7CYR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8364:krt70
gene id: 8364:krt70
uniprot id: Q6DK80
names: Similarity
messages: Belongs to the intermediate filament family.

8364:hmgxb4
gene id: 8364:hmgxb4
uniprot id: Q5BL56
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with nlk.2.
messages: Negatively regulates Wnt/beta-catenin signaling during development.
messages: Nucleus

8364:ankrd13b
gene id: 8364:ankrd13b
uniprot id: A0A8J0S5V6
uniprot id: A0A8J0SA85
uniprot id: A0A8J0SBV5
uniprot id: A0A8J0SCK8
uniprot id: A4IIS1
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

8364:LOC116407569
gene id: 8364:LOC116407569
uniprot id: A0A803JHR0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:lefty
gene id: 8364:lefty
uniprot id: B3DLA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

8364:gpr52
gene id: 8364:gpr52
uniprot id: A0A803K7S0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:tmem50a
gene id: 8364:tmem50a
uniprot id: A4QNG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

8364:tax1bp3
gene id: 8364:tax1bp3
uniprot id: Q6P4W4
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.
messages: Nucleus

8364:fgf11
gene id: 8364:fgf11
uniprot id: A0A803JQJ3
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

8364:LOC100492603
gene id: 8364:LOC100492603
uniprot id: A0A8J1JG64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:snx33
gene id: 8364:snx33
uniprot id: Q28GP7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking, both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes (By similarity).
messages: The PX and BAR domains mediate association with membranes and are required for membrane tubulation.
messages: cytosol

8364:LOC100494266
gene id: 8364:LOC100494266
uniprot id: A0A6I8R1L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

8364:LOC116408026
gene id: 8364:LOC116408026
uniprot id: A0A803JYC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

8364:LOC100490602
gene id: 8364:LOC100490602
uniprot id: A0A8J1JEG1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natural cytotoxicity receptor (NCR) family.
messages: Cell membrane
messages: Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6.
messages: Membrane

8364:rassf1
gene id: 8364:rassf1
uniprot id: F6VX16
names: Subcellular Location Annotation
messages: cytoskeleton

8364:prkg2
gene id: 8364:prkg2
uniprot id: F6S6L9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

8364:LOC105946059
gene id: 8364:LOC105946059
uniprot id: A0A8J1JKW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

8364:gpr119
gene id: 8364:gpr119
uniprot id: A0A6I8S2X8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:abca10
gene id: 8364:abca10
uniprot id: A0A8J1J1B6
names: Subcellular Location Annotation
messages: Membrane

8364:adgrg4
gene id: 8364:adgrg4
uniprot id: A0A8J1IQU1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:LOC101731912
gene id: 8364:LOC101731912
uniprot id: A0A803J265
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:ocln
gene id: 8364:ocln
uniprot id: Q28GC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
messages: Membrane
messages: tight junction

8364:becn1
gene id: 8364:becn1
uniprot id: Q4A1L3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beclin family.
messages: Component of the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: May be proteolytically processed by caspases; the C-terminal fragment(s) may induce apoptosis.
messages: Mitochondrion membrane
messages: Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms (By similarity). Involved in endocytosis including endosome formation in neuronal cells (By similarity).
messages: autophagosome
messages: trans-Golgi network membrane

8364:glb1l2
gene id: 8364:glb1l2
uniprot id: A0A6I8PLI9
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

8364:vps53
gene id: 8364:vps53
uniprot id: A0A6I8QVJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

8364:lhx4
gene id: 8364:lhx4
uniprot id: A0A6I8STY8
names: Subcellular Location Annotation
messages: Nucleus

8364:mrpl45
gene id: 8364:mrpl45
uniprot id: Q4QQQ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL45 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

8364:tmtc1
gene id: 8364:tmtc1
uniprot id: A0A6I8QHD5
uniprot id: A0A8J1J9I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

8364:copz1
gene id: 8364:copz1
uniprot id: A0A8J1J1E1
uniprot id: Q28HL1
uniprot id: Q6P383
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

8364:LOC105948111
gene id: 8364:LOC105948111
uniprot id: A0A8J0SWQ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:copg2
gene id: 8364:copg2
uniprot id: A0A6I8QRS1
uniprot id: Q66JI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

8364:ahsa1
gene id: 8364:ahsa1
uniprot id: F6WM96
names: Similarity
messages: Belongs to the AHA1 family.

8364:adh1a
gene id: 8364:adh1a
uniprot id: F6QUZ3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

8364:nqo1
gene id: 8364:nqo1
uniprot id: Q28HD6
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

8364:LOC100494325
gene id: 8364:LOC100494325
uniprot id: A0A8J1IPX8
names: Similarity
messages: Belongs to the peptidase C1 family.

8364:chrna7
gene id: 8364:chrna7
uniprot id: A0A7D9NLQ4
uniprot id: A0A8J0SY64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:ctnnbip1
gene id: 8364:ctnnbip1
uniprot id: Q66IL2
names: Similarity
messages: Belongs to the CTNNBIP1 family.

8364:LOC101734051
gene id: 8364:LOC101734051
uniprot id: A0A8J1JPT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

8364:LOC116406454
gene id: 8364:LOC116406454
uniprot id: A0A803K552
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

8364:dao
gene id: 8364:dao
uniprot id: A0A6I8QWG7
uniprot id: Q0VGX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

8364:ltb4dh
gene id: 8364:ltb4dh
uniprot id: Q642N4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer or homodimer.

8364:prkcg
gene id: 8364:prkcg
uniprot id: A0A6I8RBU0
uniprot id: A0A6I8S9R6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.
messages: Cytoplasm
messages: Membrane

8364:LOC548351
gene id: 8364:LOC548351
uniprot id: F6YUN6
uniprot id: Q28EX0
names: Similarity
messages: Belongs to the aldo/keto reductase family.

8364:LOC108648300
gene id: 8364:LOC108648300
uniprot id: A0A8J0T699
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:igsf3
gene id: 8364:igsf3
uniprot id: A0JPB1
names: Subcellular Location Annotation
messages: Membrane

8364:LOC101732252
gene id: 8364:LOC101732252
uniprot id: A0A6I8T1W4
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC116409654
gene id: 8364:LOC116409654
uniprot id: A0A6I8Q606
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:gfm2
gene id: 8364:gfm2
uniprot id: A0A6I8RRM6
uniprot id: A0A8J0QKA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
messages: Mitochondrion

8364:tmem41a
gene id: 8364:tmem41a
uniprot id: A0A6I8PYM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

8364:LOC101732409
gene id: 8364:LOC101732409
uniprot id: A0A8J0R0N3
names: Subcellular Location Annotation
messages: Secreted

8364:cfap157
gene id: 8364:cfap157
uniprot id: F7D2G5
uniprot id: Q0VFN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP157 family.
messages: Specifically required during spermatogenesis for flagellum morphogenesis and sperm motility.
messages: cilium basal body

8364:LOC100494911
gene id: 8364:LOC100494911
uniprot id: A0A8J1JWT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:efna2
gene id: 8364:efna2
uniprot id: B1WAY1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:pyy
gene id: 8364:pyy
uniprot id: A0A803JCZ8
uniprot id: Q0IIS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

8364:s1pr3
gene id: 8364:s1pr3
uniprot id: A0A803K6E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100485134
gene id: 8364:LOC100485134
uniprot id: F7C6D9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:aldh1a1
gene id: 8364:aldh1a1
uniprot id: F7BRA8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

8364:tollip
gene id: 8364:tollip
uniprot id: Q6DFR0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tollip family.
messages: Both ATG8-interaction motifs (AIM1 and AIM2) are required for the association with ATG8 family proteins.
messages: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity). In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes (By similarity). Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P) (By similarity).
messages: Cytoplasm
messages: Early endosome
messages: Endosome
messages: Interacts with ATG8 family proteins (via AIM motifs), and ubiquitin (via CUE domain). Found in a complex with TOM1; interacts (via N-terminus) with TOM1 (via GAT domain); the interactions leads to TOM1-recruitment to endosomes and inhibition of TOLLIP binding to PtdIns(3)P (By similarity).
messages: The N-terminal TOM1-binding domain (residues 1-53) is a disordered domain that partially folds when bound to the GAT domain of TOM1.

8364:mtbp
gene id: 8364:mtbp
uniprot id: Q0P4G8
names: Function
names: Similarity
messages: Belongs to the MTBP family.
messages: May play a role in mdm2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of mdm2, thereby enhancing mdm2 stability. This promotes mdm2-mediated ubiquitination of p53/TP53 and its subsequent degradation (By similarity).

8364:cox18
gene id: 8364:cox18
uniprot id: A0A8J0PI29
uniprot id: A0A8J0T0I1
uniprot id: B7ZU56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

8364:LOC100145174
gene id: 8364:LOC100145174
uniprot id: F7BI54
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:LOC116412161
gene id: 8364:LOC116412161
uniprot id: A0A8J1JUU4
names: Subcellular Location Annotation
messages: Membrane

8364:rdh14
gene id: 8364:rdh14
uniprot id: F6SFY1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8364:p2ry4
gene id: 8364:p2ry4
uniprot id: F6TLV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC101731924
gene id: 8364:LOC101731924
uniprot id: A0A1B8Y762
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:kif18a
gene id: 8364:kif18a
uniprot id: A0A6I8R2V2
uniprot id: A0A8J0SIL4
uniprot id: A0A8J0T214
uniprot id: A4II97
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8364:cyp7b1
gene id: 8364:cyp7b1
uniprot id: B1H3I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

8364:runx2
gene id: 8364:runx2
uniprot id: A0A8J0SN14
uniprot id: B5BNX8
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100497161
gene id: 8364:LOC100497161
uniprot id: A0A8J0SXP0
uniprot id: A0A8J1IM62
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:LOC116411610
gene id: 8364:LOC116411610
uniprot id: A0A8J1JQB6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:cct3
gene id: 8364:cct3
uniprot id: Q6P2X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

8364:ptch2
gene id: 8364:ptch2
uniprot id: F6ZXC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

8364:tenm3
gene id: 8364:tenm3
uniprot id: A0A8J1J0C3
uniprot id: A0A8J1J0C4
uniprot id: A0A8J1J0C8
uniprot id: A0A8J1J0D5
uniprot id: A0A8J1J0E2
uniprot id: A0A8J1J2N9
uniprot id: A0A8J1J3M1
uniprot id: A0A8J1J3M6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:LOC101734494
gene id: 8364:LOC101734494
uniprot id: Q28J31
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:satpa
gene id: 8364:satpa
uniprot id: A0A6I8SL51
names: Similarity
messages: Belongs to the SUA5 family.

8364:capn10
gene id: 8364:capn10
uniprot id: A0A8J0QPN9
uniprot id: A0A8J1JKM5
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:cyp24a1
gene id: 8364:cyp24a1
uniprot id: F7BA13
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:LOC100491339
gene id: 8364:LOC100491339
uniprot id: A0A803J1X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

8364:ppp1r1b
gene id: 8364:ppp1r1b
uniprot id: A4II07
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

8364:tmem14c
gene id: 8364:tmem14c
uniprot id: Q0V9B0
names: Similarity
messages: Belongs to the TMEM14 family.

8364:ckap2
gene id: 8364:ckap2
uniprot id: A0A8J0R1A8
uniprot id: F7DBM0
names: Similarity
messages: Belongs to the CKAP2 family.

8364:lsr
gene id: 8364:lsr
uniprot id: B1H2L0
uniprot id: L7N3M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

8364:LOC100488533
gene id: 8364:LOC100488533
uniprot id: A0A1B8Y4L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:bpnt1
gene id: 8364:bpnt1
uniprot id: F6TC68
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

8364:tmem19
gene id: 8364:tmem19
uniprot id: A0A8J1J9T4
uniprot id: Q0P4L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

8364:LOC101734375
gene id: 8364:LOC101734375
uniprot id: A0A6I8PND5
uniprot id: A0A8J0SLN5
uniprot id: A0A8J0SN35
uniprot id: A0A8J1JKW9
uniprot id: A0A8J1JKX2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:sppl2b
gene id: 8364:sppl2b
uniprot id: A0A8J0SRR0
uniprot id: A0A8J0SSU0
uniprot id: Q05AQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Endosome membrane
messages: Lysosome membrane
messages: Membrane

8364:fbxo34
gene id: 8364:fbxo34
uniprot id: A0A6I8Q0K6
uniprot id: A9JTT0
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

8364:acly
gene id: 8364:acly
uniprot id: A0A6I8QYX1
uniprot id: Q66JH9
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
messages: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.

8364:cckbr
gene id: 8364:cckbr
uniprot id: A0A803JLM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:mrgbp
gene id: 8364:mrgbp
uniprot id: Q561N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EAF7 family.
messages: Nucleus

8364:rbbp4
gene id: 8364:rbbp4
uniprot id: A0A6I8QVR5
uniprot id: Q28IL0
names: Subcellular Location Annotation
messages: Nucleus

8364:itpripl2
gene id: 8364:itpripl2
uniprot id: A0A8J0QHX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Belongs to the mab-21 family.
messages: Membrane

8364:LOC116407661
gene id: 8364:LOC116407661
uniprot id: A0A8J1IUK4
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:mipep
gene id: 8364:mipep
uniprot id: A0A8J0QV23
uniprot id: F6WFK8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

8364:scarf2
gene id: 8364:scarf2
uniprot id: A0A803JVX0
uniprot id: A0A8J1IT50
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC116406716
gene id: 8364:LOC116406716
uniprot id: A0A8J1IS07
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100496982
gene id: 8364:LOC100496982
uniprot id: A0A8J1JLC7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:snrpd1
gene id: 8364:snrpd1
uniprot id: Q6GLH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.

8364:chmp3
gene id: 8364:chmp3
uniprot id: A0A8J0SMJ4
uniprot id: Q5BKM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Endosome
messages: Late endosome membrane
messages: Membrane
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor (By similarity).
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially (By similarity).
messages: cytosol

8364:kiaa1324l
gene id: 8364:kiaa1324l
uniprot id: A0A8J0QKN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Membrane

8364:ube2d4
gene id: 8364:ube2d4
uniprot id: A0A803K2G6
uniprot id: A0A8J0SG95
uniprot id: F6VCY8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8364:cdc25b
gene id: 8364:cdc25b
uniprot id: F7A6V5
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

8364:ribc1
gene id: 8364:ribc1
uniprot id: B5DEV2
uniprot id: F6PII4
names: Similarity
messages: Belongs to the RIB43A family.

8364:vps26a
gene id: 8364:vps26a
uniprot id: Q28HT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity).
messages: Belongs to the VPS26 family.
messages: Component of the heterotrimeric retromer cargo-selective complex (CSC) which is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants (By similarity).
messages: Cytoplasm
messages: Early endosome
messages: Endosome membrane

8364:smn1
gene id: 8364:smn1
uniprot id: A0A8J0SZ32
uniprot id: A4QNA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMN family.
messages: Cajal body
messages: Perikaryon
messages: Z line
messages: gem
messages: neuron projection

8364:adh1b
gene id: 8364:adh1b
uniprot id: Q5I0R0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

8364:pax2
gene id: 8364:pax2
uniprot id: Q28IR6
names: Subcellular Location Annotation
messages: Nucleus

8364:gabrr3
gene id: 8364:gabrr3
uniprot id: F6QTQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:prickle3
gene id: 8364:prickle3
uniprot id: A0A803K7N2
uniprot id: A0A8J0QRA0
uniprot id: A0A8J0R1P6
uniprot id: A0A8J0SUE8
uniprot id: A0A8J1IN69
uniprot id: A0A8J1IR98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prickle / espinas / testin family.
messages: Cell membrane
messages: Membrane

8364:LOC100496628
gene id: 8364:LOC100496628
uniprot id: F7ATX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:thoc5
gene id: 8364:thoc5
uniprot id: A0A6I8SUI0
uniprot id: G1K3H9
uniprot id: Q28DG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity).
messages: Belongs to the THOC5 family.
messages: Component of the THO subcomplex of the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with thoc7 (By similarity).
messages: Cytoplasm
messages: May be involved in cell differentiation.
messages: Nucleus
messages: Nucleus speckle

8364:LOC116410964
gene id: 8364:LOC116410964
uniprot id: A0A8J1JNF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEATR1/UTP10 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

8364:plxnb2
gene id: 8364:plxnb2
uniprot id: A0A6I8R895
uniprot id: A0A8J0PJH0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8364:LOC100496766
gene id: 8364:LOC100496766
uniprot id: A0A8J0QJY4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:inpp5j
gene id: 8364:inpp5j
uniprot id: A0A8J0QNH3
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.

8364:mos
gene id: 8364:mos
uniprot id: A0A8J1JPQ9
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC100492409
gene id: 8364:LOC100492409
uniprot id: A0A8J1IWQ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: May be involved in iron transport and iron homeostasis.
messages: Membrane

8364:LOC100498066
gene id: 8364:LOC100498066
uniprot id: A0A8J0SYU7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8364:jakmip1
gene id: 8364:jakmip1
uniprot id: A0A6I8R2D8
uniprot id: A0A6I8SVC7
uniprot id: A0A8J1IZV3
uniprot id: B1H0Z5
names: Similarity
messages: Belongs to the JAKMIP family.

8364:LOC116406627
gene id: 8364:LOC116406627
uniprot id: A0A8J1IQ44
names: Subcellular Location Annotation
messages: Nucleus speckle

8364:ube2h
gene id: 8364:ube2h
uniprot id: Q6DJ44
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8364:scn3a
gene id: 8364:scn3a
uniprot id: A0A8J0SWE1
uniprot id: A0A8J1IT15
uniprot id: A0A8J1IT19
uniprot id: A0A8J1IVF8
uniprot id: A0A8J1IW78
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

8364:slc39a5
gene id: 8364:slc39a5
uniprot id: A0A8J0SER4
uniprot id: B1H196
names: Subcellular Location Annotation
messages: Membrane

8364:efna4
gene id: 8364:efna4
uniprot id: A0A6I8SYQ8
uniprot id: A0A803K573
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:atp5f1d
gene id: 8364:atp5f1d
uniprot id: F6TBL3
names: Similarity
messages: Belongs to the ATPase epsilon chain family.

8364:cldn5
gene id: 8364:cldn5
uniprot id: F6TD70
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8364:LOC100493210
gene id: 8364:LOC100493210
uniprot id: A0A8J0QUK7
names: Similarity
messages: Belongs to the cyclin family.

8364:vnn1
gene id: 8364:vnn1
uniprot id: F6XDT7
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

8364:tmem254
gene id: 8364:tmem254
uniprot id: Q5I0Q8
names: Subcellular Location Annotation
messages: Membrane

8364:sqle
gene id: 8364:sqle
uniprot id: A0A6I8QCI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the squalene monooxygenase family.
messages: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
messages: Endoplasmic reticulum membrane

8364:atf7ip
gene id: 8364:atf7ip
uniprot id: A0A803JJR8
uniprot id: A0A8J0SKR3
uniprot id: A0A8J1JIR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

8364:calhm6
gene id: 8364:calhm6
uniprot id: A0A6I8SE41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

8364:uchl5
gene id: 8364:uchl5
uniprot id: A0A7D9NKY2
names: Similarity
messages: Belongs to the peptidase C12 family.

8364:tmprss2.7
gene id: 8364:tmprss2.7
uniprot id: A0A8J1J3G5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:ikzf5
gene id: 8364:ikzf5
uniprot id: A0JPB4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 'Pegasus' was the winged horse in Greek mythology.
messages: Belongs to the Ikaros C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Probably self-associates.
messages: Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence (By similarity).

8364:cox4i2
gene id: 8364:cox4i2
uniprot id: Q28FR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

8364:LOC116406807
gene id: 8364:LOC116406807
uniprot id: A0A6I8QJG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:pfn4
gene id: 8364:pfn4
uniprot id: A0A6I8QTH5
names: Similarity
messages: Belongs to the profilin family.

8364:mertk
gene id: 8364:mertk
uniprot id: A0A6I8QWR9
uniprot id: A0A6I8S3G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cell membrane
messages: Membrane

8364:csrnp1
gene id: 8364:csrnp1
uniprot id: Q0P4X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

8364:itpkc
gene id: 8364:itpkc
uniprot id: Q0VA57
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

8364:cldn3
gene id: 8364:cldn3
uniprot id: Q6DJ92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the claudin family.
messages: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8364:cfi
gene id: 8364:cfi
uniprot id: Q4V785
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC101730220
gene id: 8364:LOC101730220
uniprot id: A0A8J1JLV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

8364:numbl
gene id: 8364:numbl
uniprot id: A0A6I8RU70
names: Function
messages: Plays a role in the process of neurogenesis.

8364:minar1
gene id: 8364:minar1
uniprot id: A0A6I8PR29
names: Similarity
messages: Belongs to the MINAR family.

8364:nipa2
gene id: 8364:nipa2
uniprot id: Q7M563
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

8364:ptgr2
gene id: 8364:ptgr2
uniprot id: Q0V9S8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer.

8364:hsdl2
gene id: 8364:hsdl2
uniprot id: Q66KC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Has apparently no steroid dehydrogenase activity.
messages: Peroxisome

8364:LOC116409530
gene id: 8364:LOC116409530
uniprot id: A0A8J1JBM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:atp5f1b
gene id: 8364:atp5f1b
uniprot id: Q6NWX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

8364:il17rel
gene id: 8364:il17rel
uniprot id: A0A6I8PMN8
uniprot id: A0A8J1JAF5
uniprot id: A0A8J1JDY8
names: Subcellular Location Annotation
messages: Cell membrane

8364:rgn
gene id: 8364:rgn
uniprot id: Q6DF62
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMP-30/CGR1 family.
messages: Binds 1 divalent metal cation per subunit. Most active with Zn(2+) and Mn(2+) ions. The physiological cofactor is most likely Ca(2+) or Mg(2+).
messages: Cytoplasm
messages: Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).

8364:st3gal4
gene id: 8364:st3gal4
uniprot id: Q28CN5
uniprot id: Q703F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8364:rabggtb
gene id: 8364:rabggtb
uniprot id: A9JTX7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

8364:cactin
gene id: 8364:cactin
uniprot id: A0A7D9NL66
names: Similarity
messages: Belongs to the CACTIN family.

8364:pmpca
gene id: 8364:pmpca
uniprot id: A0A6I8R6W5
names: Similarity
messages: Belongs to the peptidase M16 family.

8364:btk
gene id: 8364:btk
uniprot id: B3DLB1
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

8364:LOC100495331
gene id: 8364:LOC100495331
uniprot id: A0A8J1JZW3
uniprot id: F7C4B6
names: Similarity
messages: Belongs to the NXPE family.

8364:prdm14
gene id: 8364:prdm14
uniprot id: F6TMC6
names: Subcellular Location Annotation
messages: Nucleus

8364:best4
gene id: 8364:best4
uniprot id: A0A803KJN0
uniprot id: B1WBH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

8364:fpr3
gene id: 8364:fpr3
uniprot id: A0A8J1JY46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

8364:LOC100488828
gene id: 8364:LOC100488828
uniprot id: A0A6I8RS14
uniprot id: A0A8J1JP43
uniprot id: A0A8J1JP52
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:akap8
gene id: 8364:akap8
uniprot id: A0A6I8PWY2
uniprot id: A0A8J0S5Y2
uniprot id: A0A8J0S5Y8
uniprot id: A0A8J0SAC0
uniprot id: A0A8J0SCP5
uniprot id: A0A8J0SD04
uniprot id: A0A8J0SZ42
uniprot id: F6QKV2
uniprot id: Q501K7
names: Similarity
messages: Belongs to the AKAP95 family.

8364:LOC100496848
gene id: 8364:LOC100496848
uniprot id: A0A8J1IPU1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:cep290
gene id: 8364:cep290
uniprot id: A0A6I8S3J2
names: Subcellular Location Annotation
messages: cilium basal body

8364:pdpk1
gene id: 8364:pdpk1
uniprot id: A0A6I8QZN8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.

8364:dusp13
gene id: 8364:dusp13
uniprot id: A0A803JWQ7
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

8364:tfap2e
gene id: 8364:tfap2e
uniprot id: B3DL96
names: Similarity
messages: Belongs to the AP-2 family.

8364:lhx3
gene id: 8364:lhx3
uniprot id: A0A803J6Z0
uniprot id: A0A803JMR6
uniprot id: A0A8J1IQI6
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100497034
gene id: 8364:LOC100497034
uniprot id: A0A8J0QXU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

8364:LOC101733132
gene id: 8364:LOC101733132
uniprot id: A0A6I8PZQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane

8364:tmsb10
gene id: 8364:tmsb10
uniprot id: A0A8J0SAQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

8364:dlgap2
gene id: 8364:dlgap2
uniprot id: A0A803JFF0
uniprot id: A0A8J1JKG3
uniprot id: A0A8J1JP31
names: Similarity
messages: Belongs to the SAPAP family.

8364:LOC100494900
gene id: 8364:LOC100494900
uniprot id: A0A8J1JLY4
uniprot id: A0A8J1JLY7
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:sorcs3
gene id: 8364:sorcs3
uniprot id: F6WAK4
names: Similarity
messages: Belongs to the VPS10-related sortilin family. SORCS subfamily.

8364:eif5
gene id: 8364:eif5
uniprot id: Q66II6
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

8364:prkce
gene id: 8364:prkce
uniprot id: F7D0A4
uniprot id: Q08BT6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration.
messages: Cell membrane
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.
messages: Nucleus
messages: cytoskeleton
messages: perinuclear region

8364:sptbn5
gene id: 8364:sptbn5
uniprot id: A0A8J1INV9
names: Similarity
messages: Belongs to the spectrin family.

8364:LOC108646268
gene id: 8364:LOC108646268
uniprot id: A0A8J0SSP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:cldn6.2
gene id: 8364:cldn6.2
uniprot id: A0A6I8QUN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8364:arl5b
gene id: 8364:arl5b
uniprot id: A0A8J0SMY5
uniprot id: Q6DIM7
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

8364:ocrl
gene id: 8364:ocrl
uniprot id: A0A6I8R521
uniprot id: L7N2Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: phagosome membrane

8364:nop14
gene id: 8364:nop14
uniprot id: F7DV09
uniprot id: L7N3G9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP14 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
messages: nucleolus

8364:mfsd1
gene id: 8364:mfsd1
uniprot id: A0A6I8Q075
uniprot id: A0A8J0QMZ9
names: Subcellular Location Annotation
messages: Membrane

8364:astl
gene id: 8364:astl
uniprot id: A0A6I8RTK8
uniprot id: A0A803K5M3
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:abca4
gene id: 8364:abca4
uniprot id: A0A6I8RDT6
uniprot id: Q5YG24
names: Subcellular Location Annotation
messages: Membrane

8364:LOC101733182
gene id: 8364:LOC101733182
uniprot id: B5DDY3
uniprot id: Q28DR4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by pak2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

8364:capn12
gene id: 8364:capn12
uniprot id: A0A6I8PTX7
uniprot id: A0A8J1IM19
uniprot id: A0A8J1IP81
uniprot id: A0A8J1IPX5
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:sema4b
gene id: 8364:sema4b
uniprot id: A0A6I8RU83
uniprot id: A0A8J0T1Y9
uniprot id: A0A8J1JDK3
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:nppa
gene id: 8364:nppa
uniprot id: A0A6I8RJK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

8364:dnah7
gene id: 8364:dnah7
uniprot id: A0A8J0QU27
uniprot id: F7CJM1
names: Similarity
messages: Belongs to the dynein heavy chain family.

8364:zdhhc8
gene id: 8364:zdhhc8
uniprot id: Q2THW1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8364:dck.1
gene id: 8364:dck.1
uniprot id: Q5BL83
names: Similarity
messages: Belongs to the DCK/DGK family.

8364:plod2
gene id: 8364:plod2
uniprot id: A0A6I8S8F1
uniprot id: F6RBU2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

8364:neo1
gene id: 8364:neo1
uniprot id: A0A6I8RQA6
uniprot id: A0A8J0QI24
uniprot id: A0A8J0SI45
uniprot id: A0A8J0SQ41
uniprot id: A0A8J0SRQ1
uniprot id: A0A8J0SRQ5
uniprot id: A0A8J0SSS5
uniprot id: A0A8J0ST09
uniprot id: F7B3P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. DCC family.
messages: Membrane

8364:eif2a
gene id: 8364:eif2a
uniprot id: A0A8J0QCW4
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

8364:cds1
gene id: 8364:cds1
uniprot id: A0A6I8RK00
uniprot id: A0A8J0QP56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

8364:mapkap1
gene id: 8364:mapkap1
uniprot id: A4IIM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SIN1 family.
messages: Essential component of the TORC2 complex, which plays a critical role in akt1 'Ser-473' phosphorylation, and may modulate the phosphorylation of pkca and regulate actin cytoskeleton organization. May interact with a MAP kinase. May act on Ras-regulated pathways (By similarity).
messages: Part of the target of rapamycin 2 complex (TORC2).

8364:cmtm3
gene id: 8364:cmtm3
uniprot id: F6TFQ6
names: Subcellular Location Annotation
messages: Membrane

8364:tube1
gene id: 8364:tube1
uniprot id: Q28FD0
names: Similarity
messages: Belongs to the tubulin family.

8364:crk
gene id: 8364:crk
uniprot id: Q6GLF5
names: Similarity
messages: Belongs to the CRK family.

8364:LOC116411524
gene id: 8364:LOC116411524
uniprot id: A0A8J1JPJ1
names: Subcellular Location Annotation
messages: Nucleus

8364:il17ra
gene id: 8364:il17ra
uniprot id: A0A803JTS9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:opn1sw
gene id: 8364:opn1sw
uniprot id: F6RHJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

8364:LOC105947814
gene id: 8364:LOC105947814
uniprot id: A0A8J1JWS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:slc9a3
gene id: 8364:slc9a3
uniprot id: A0A6I8S0S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Membrane
messages: Recycling endosome membrane

8364:clcn4
gene id: 8364:clcn4
uniprot id: F6UIB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

8364:tyw1
gene id: 8364:tyw1
uniprot id: A4IHE0
names: Function
names: Similarity
messages: Belongs to the TYW1 family.
messages: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis.

8364:frmd8
gene id: 8364:frmd8
uniprot id: Q0IJ35
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Promotes the cell surface stability of RHBDF1 and RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on RHBDF proteins, involved in ADAM17-mediated ligand shedding (By similarity). May negatively regulate Wnt signaling (By similarity).
messages: cytosol

8364:LOC100496639
gene id: 8364:LOC100496639
uniprot id: A0A8J1ISF8
names: Similarity
messages: Belongs to the MHC class I family.

8364:fbxo25
gene id: 8364:fbxo25
uniprot id: A0A803JZI1
uniprot id: Q569D4
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100493569
gene id: 8364:LOC100493569
uniprot id: A0A6I8SPN7
names: Subcellular Location Annotation
messages: Membrane

8364:tmem132e
gene id: 8364:tmem132e
uniprot id: A0A6I8S8N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

8364:capn8.1
gene id: 8364:capn8.1
uniprot id: A0A8J1JLX5
uniprot id: Q28C80
names: Similarity
messages: Belongs to the peptidase C2 family.

8364:fam91a1
gene id: 8364:fam91a1
uniprot id: A9UM80
names: Similarity
messages: Belongs to the FAM91 family.

8364:bves
gene id: 8364:bves
uniprot id: A0A8J0SKL8
uniprot id: B1H1G2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the popeye family.
messages: Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. May play a role in vamp3-mediated vesicular transport and recycling of different receptor molecules. May be involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. May induce primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. May be involved in epithelial movement during corneal sheet formation and regeneration. May play a role in the regulation of cell shape and movement by modulating the Rho-GTPase activity. May be involved in skeletal muscle and heart development as well as in the maintenance of heart function. May also be involved in striated muscle regeneration and in the regulation of cell spreading (By similarity).
messages: Lateral cell membrane
messages: Membrane
messages: caveola
messages: sarcolemma
messages: tight junction

8364:dclre1c
gene id: 8364:dclre1c
uniprot id: A0A6I8S3B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

8364:dock9
gene id: 8364:dock9
uniprot id: A0A6I8QTK5
uniprot id: A0A6I8STS0
uniprot id: A0A8J0SEN4
uniprot id: A0A8J0SY73
uniprot id: A0A8J0T1D5
uniprot id: A0A8J1J4V6
uniprot id: A0A8J1J4W1
uniprot id: A0A8J1J4W3
uniprot id: A0A8J1J4W6
uniprot id: A0A8J1J4X0
uniprot id: A0A8J1J4X2
uniprot id: A0A8J1J7A8
uniprot id: A0A8J1J7B3
uniprot id: A0A8J1J8B0
uniprot id: A0A8J1J8B5
names: Similarity
messages: Belongs to the DOCK family.

8364:tef
gene id: 8364:tef
uniprot id: A0A8J1JDL9
uniprot id: F6SBH6
uniprot id: Q28DN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

8364:znf598
gene id: 8364:znf598
uniprot id: B2GTY7
names: Similarity
messages: Belongs to the ZNF598/HEL2 family.

8364:mindy3
gene id: 8364:mindy3
uniprot id: A0A8J1JMQ1
uniprot id: Q6NX27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
messages: Nucleus

8364:cyp51a1
gene id: 8364:cyp51a1
uniprot id: Q28CJ0
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:pdlim1
gene id: 8364:pdlim1
uniprot id: A0A8J0SQA2
uniprot id: A0A8J0T472
uniprot id: A0A8J0T4J0
uniprot id: F6VLA4
names: Subcellular Location Annotation
messages: Z line

8364:cdc7
gene id: 8364:cdc7
uniprot id: Q28I25
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC100492272
gene id: 8364:LOC100492272
uniprot id: A0A8J0R0D6
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:spam1
gene id: 8364:spam1
uniprot id: A0A803K0H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Membrane

8364:eef1a2
gene id: 8364:eef1a2
uniprot id: Q5I0S9
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

8364:LOC100490841
gene id: 8364:LOC100490841
uniprot id: A0A8J1JBX4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:arhgap32
gene id: 8364:arhgap32
uniprot id: A0A6I8PZJ5
uniprot id: A0A6I8QDM5
uniprot id: A0A6I8QN72
uniprot id: A0A6I8RZ78
uniprot id: A0A8J0R548
uniprot id: A0A8J0R5Q7
names: Similarity
messages: Belongs to the PX domain-containing GAP family.

8364:hoxd3
gene id: 8364:hoxd3
uniprot id: A0A6I8RM12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

8364:LOC100492134
gene id: 8364:LOC100492134
uniprot id: A0A8J1JBU5
names: Subcellular Location Annotation
messages: Secreted

8364:wnt4
gene id: 8364:wnt4
uniprot id: A0A8J0QH29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8364:LOC100490141
gene id: 8364:LOC100490141
uniprot id: A0A8J1IQJ1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:trpm2
gene id: 8364:trpm2
uniprot id: A0A803K450
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily.
messages: Cell membrane
messages: Membrane

8364:LOC116409585
gene id: 8364:LOC116409585
uniprot id: A0A8J1J8I6
names: Subcellular Location Annotation
messages: Membrane

8364:iws1
gene id: 8364:iws1
uniprot id: A0A5S6KA86
uniprot id: Q505H7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IWS1 family.
messages: Nucleus
messages: Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts.

8364:cdc42ep1
gene id: 8364:cdc42ep1
uniprot id: A0A6I8QAF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

8364:por
gene id: 8364:por
uniprot id: A0A6I8R571
uniprot id: A0A6I8RDV9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

8364:LOC116407581
gene id: 8364:LOC116407581
uniprot id: A0A6I8SFV2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:LOC116412150
gene id: 8364:LOC116412150
uniprot id: A0A8J1JUT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:slc2a11
gene id: 8364:slc2a11
uniprot id: A0A6I8QCF2
uniprot id: A0A8J0QIR7
uniprot id: A0A8J1IRJ7
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

8364:slc32a1
gene id: 8364:slc32a1
uniprot id: Q6DIV6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient (By similarity). May also transport beta-alanine (By similarity). Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake (By similarity).
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Cytoplasmic vesicle membrane
messages: Juge et al. shows that SLC32A1 is a symporter of both 4-aminobutanoate or glycine or beta-alanine with Cl(-) that operates according an electrical gradient without the need for a chemical gradient (By similarity). However Farsi et al. and Egashira et al. confirm that SLC32A1 is an antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or glycine and exclude any coupling with chloride (By similarity).
messages: Presynapse

8364:gcgr
gene id: 8364:gcgr
uniprot id: A0A8J0R5D3
uniprot id: A0A8J0T493
uniprot id: F7EEJ5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:atg4a
gene id: 8364:atg4a
uniprot id: A0A8J0T646
uniprot id: Q28IA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

8364:LOC100486700
gene id: 8364:LOC100486700
uniprot id: A0A1B8Y8T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC116412343
gene id: 8364:LOC116412343
uniprot id: A0A8J1JWR7
names: Subcellular Location Annotation
messages: Membrane

8364:gart
gene id: 8364:gart
uniprot id: A0A6I8RNQ3
names: Similarity
messages: In the C-terminal section; belongs to the GART family.
messages: In the N-terminal section; belongs to the GARS family.
messages: In the central section; belongs to the AIR synthase family.

8364:cpn1
gene id: 8364:cpn1
uniprot id: Q5FVZ6
names: Similarity
messages: Belongs to the peptidase M14 family.

8364:pcnx1
gene id: 8364:pcnx1
uniprot id: A0A6I8S8W7
uniprot id: A0A6I8SA03
uniprot id: A0A8J0R4C7
uniprot id: A0A8J0R751
uniprot id: A0A8J0SWU7
uniprot id: A0A8J1IQP4
uniprot id: F6ZTM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

8364:astl2d.1
gene id: 8364:astl2d.1
uniprot id: A0A803JSJ4
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:setd2
gene id: 8364:setd2
uniprot id: A0A6I8SKU6
uniprot id: A0A8J1JP37
names: Subcellular Location Annotation
messages: Nucleus

8364:tmed9
gene id: 8364:tmed9
uniprot id: Q5XGA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:LOC100486870
gene id: 8364:LOC100486870
uniprot id: F7C6D9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:npr1
gene id: 8364:npr1
uniprot id: A0A6I8RCV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

8364:nav2
gene id: 8364:nav2
uniprot id: A0A8J1JDN9
uniprot id: A0A8J1JDP1
uniprot id: A0A8J1JDP2
uniprot id: A0A8J1JDP5
uniprot id: A0A8J1JDP6
uniprot id: A0A8J1JDP8
uniprot id: A0A8J1JDQ0
uniprot id: A0A8J1JDQ3
uniprot id: A0A8J1JDQ4
uniprot id: A0A8J1JDQ7
uniprot id: A0A8J1JDQ8
uniprot id: A0A8J1JG63
uniprot id: A0A8J1JG72
uniprot id: A0A8J1JG77
uniprot id: A0A8J1JH74
uniprot id: A0A8J1JH79
uniprot id: A0A8J1JH84
uniprot id: B3DLJ1
names: Similarity
messages: Belongs to the Nav/unc-53 family.

8364:LOC116406445
gene id: 8364:LOC116406445
uniprot id: A0A8J0QK83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

8364:prrx1
gene id: 8364:prrx1
uniprot id: A0A8J0QMM9
uniprot id: F7ABS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

8364:slc35f4
gene id: 8364:slc35f4
uniprot id: A0A8J0QNS1
uniprot id: A0A8J0R2F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

8364:LOC116406903
gene id: 8364:LOC116406903
uniprot id: A0A8J1ISX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEAP2 family.
messages: Has an antimicrobial activity.
messages: Secreted

8364:LOC108646290
gene id: 8364:LOC108646290
uniprot id: B5DDY3
uniprot id: Q28DR4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by pak2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

8364:rae1
gene id: 8364:rae1
uniprot id: Q5FVA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat rae1 family.
messages: Cytoplasm
messages: Nucleus
messages: Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.
messages: spindle pole

8364:slc6a12
gene id: 8364:slc6a12
uniprot id: A0A803K5R7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.
messages: Cell membrane
messages: Interacts with LIN7C.
messages: Lateral cell membrane
messages: Membrane

8364:slc20a1
gene id: 8364:slc20a1
uniprot id: Q5BL44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Cell membrane
messages: Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion.

8364:nifk
gene id: 8364:nifk
uniprot id: Q6GL69
names: Subcellular Location Annotation
messages: nucleolus

8364:pola1
gene id: 8364:pola1
uniprot id: A0A8J1J3X6
uniprot id: A0A8J1J3X8
uniprot id: F6Z608
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

8364:smpdl3b
gene id: 8364:smpdl3b
uniprot id: A0A8J1J6V1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

8364:emp1
gene id: 8364:emp1
uniprot id: A0A803KGT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

8364:foxl1
gene id: 8364:foxl1
uniprot id: F6QA66
names: Subcellular Location Annotation
messages: Nucleus

8364:ltb4r2
gene id: 8364:ltb4r2
uniprot id: A0A803JTA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

8364:jak2
gene id: 8364:jak2
uniprot id: A0JM01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
messages: Endomembrane system
messages: Nucleus

8364:trpm2l
gene id: 8364:trpm2l
uniprot id: A0A803JG29
uniprot id: A0A8J1J8H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily.
messages: Cell membrane
messages: Membrane

8364:abraxas1
gene id: 8364:abraxas1
uniprot id: Q28HX0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAM175 family. Abraxas subfamily.
messages: Component of the BRCA1-A complex. Component of the BRISC complex. Interacts directly (when phosphorylated at Ser-405) with brca1. Homodimer. The phosphorylated homodimer can interact directly with two brca1 chains, giving rise to a heterotetramer (By similarity).
messages: Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of brca1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (By similarity).
messages: Nucleus
messages: Phosphorylation of Ser-405 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1.

8364:msh5
gene id: 8364:msh5
uniprot id: F7CLJ0
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.

8364:sgo2
gene id: 8364:sgo2
uniprot id: A0A6I8R4C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

8364:acer1
gene id: 8364:acer1
uniprot id: A0A7D9NJR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Membrane

8364:LOC116411749
gene id: 8364:LOC116411749
uniprot id: A0A8J1JV35
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:antxr2
gene id: 8364:antxr2
uniprot id: B2GUC8
uniprot id: F6SXU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

8364:LOC100490440
gene id: 8364:LOC100490440
uniprot id: A0A6I8RUC7
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

8364:pole
gene id: 8364:pole
uniprot id: A0A8J0QX44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: DNA polymerase II participates in chromosomal DNA replication.
messages: Nucleus

8364:pfkm
gene id: 8364:pfkm
uniprot id: A0A8J0QMK3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC116408745
gene id: 8364:LOC116408745
uniprot id: A0A8J1J6V2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:galnt17
gene id: 8364:galnt17
uniprot id: A0A6I8R4H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8364:nxpe1
gene id: 8364:nxpe1
uniprot id: A0A803JSG9
names: Similarity
messages: Belongs to the NXPE family.

8364:rgma
gene id: 8364:rgma
uniprot id: A0A8J1JAG2
uniprot id: Q6P8A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

8364:cdo1
gene id: 8364:cdo1
uniprot id: Q6P896
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cysteine dioxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.

8364:LOC100497344
gene id: 8364:LOC100497344
uniprot id: A0A6I8QSH1
uniprot id: A0A8J0R4N7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

8364:snu13
gene id: 8364:snu13
uniprot id: Q6P8E9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Identified in the spliceosome B complex. Component of the U4/U6-U5 tri-snRNP complex. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (By similarity).
messages: Nucleus
messages: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.
messages: nucleolus

8364:birc5l
gene id: 8364:birc5l
uniprot id: Q28ER3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IAP family.
messages: Component of the CPC at least composed of survivin/birc5, incenp, cdca8/borealin and/or cdca9/dasra-A, and aurkb/aurora-B. Interacts directly with incenp (via N-terminus). Interacts with rxra; the interaction is stronger in the absence of 9-cis retinoic acids (By similarity).
messages: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Does not appear to exhibit anti-apoptotic activity. Plays a role in increasing blood vessel size during development (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: The BIR2 domain is required for vascular development.
messages: Ubiquitination is required for centrosome-targeting.
messages: centromere
messages: spindle

8364:sag
gene id: 8364:sag
uniprot id: Q6P8F1
names: Similarity
messages: Belongs to the arrestin family.

8364:rps23
gene id: 8364:rps23
uniprot id: Q5HZT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Rough endoplasmic reticulum

8364:slc25a21
gene id: 8364:slc25a21
uniprot id: A0A6I8PN78
uniprot id: A0A8J0PJH6
uniprot id: A0A8J1ILI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8364:LOC100489177
gene id: 8364:LOC100489177
uniprot id: A0A8J0QY62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:gjb4
gene id: 8364:gjb4
uniprot id: A0A6I8Q3Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8364:avpr2.2
gene id: 8364:avpr2.2
uniprot id: A0A6I8QG78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane

8364:chpf
gene id: 8364:chpf
uniprot id: A0A803K2L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

8364:ocel1.2
gene id: 8364:ocel1.2
uniprot id: A0A803K3A8
uniprot id: A0JM94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
messages: Membrane
messages: tight junction

8364:rpl10a
gene id: 8364:rpl10a
uniprot id: A0A8J0SCU2
uniprot id: A0A8J0SDM6
uniprot id: B0BM93
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

8364:mcm6.2
gene id: 8364:mcm6.2
uniprot id: Q6P1V8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. The existence of maternal and zygotic forms of mcm3 and mcm6 suggests that specific forms of mcm2-7 complexes may be used during different stages of development. May replace mmcm6 in the mcm2-7 complex (By similarity).
messages: Belongs to the MCM family.
messages: Component of the mcm2-7 complex (RLF-M). The complex forms a toroidal hexameric ring with the proposed subunit order mcm2-mcm6-mcm4-mcm7-mcm3-mcm5. Begins to associate with zmcm3, mcm4 and mcm7 into mcm complexes at the neurula stage (By similarity).
messages: Nucleus

8364:st8sia3
gene id: 8364:st8sia3
uniprot id: A0A803K2R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8364:gle1
gene id: 8364:gle1
uniprot id: A0A8J0QL07
uniprot id: A0A8J0R637
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLE1 family.
messages: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).
messages: nuclear pore complex

8364:ppia
gene id: 8364:ppia
uniprot id: F6ZR16
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

8364:vars1
gene id: 8364:vars1
uniprot id: A0A8J0R5T7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

8364:map4
gene id: 8364:map4
uniprot id: A0A6I8QWL9
uniprot id: A0A803JIB1
uniprot id: A0A803JP81
uniprot id: A0A803K514
uniprot id: A0A8J1JP70
uniprot id: A0A8J1JP71
uniprot id: A0A8J1JP74
uniprot id: A0A8J1JP80
uniprot id: A0A8J1JRP4
uniprot id: A0A8J1JSX7
uniprot id: A0A8J1JSY4
uniprot id: A0A8J1JSZ0
names: Subcellular Location Annotation
messages: cytoskeleton

8364:kcne1
gene id: 8364:kcne1
uniprot id: A0A8J1J5X9
names: Similarity
messages: Belongs to the potassium channel KCNE family.

8364:b4galt3
gene id: 8364:b4galt3
uniprot id: A0A803JMC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

8364:kcns1
gene id: 8364:kcns1
uniprot id: A0A8J0QUE4
names: Subcellular Location Annotation
messages: Membrane

8364:pura
gene id: 8364:pura
uniprot id: A9UL75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

8364:LOC100490494
gene id: 8364:LOC100490494
uniprot id: A0A8J0ST81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

8364:adamts18
gene id: 8364:adamts18
uniprot id: A0A6I8QIW1
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:sem1
gene id: 8364:sem1
uniprot id: Q28EZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DSS1/SEM1 family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Nucleus

8364:slc25a19
gene id: 8364:slc25a19
uniprot id: A0A6I8QNH7
uniprot id: F7CA29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8364:slc2a11l2
gene id: 8364:slc2a11l2
uniprot id: A0A8J0QH34
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

8364:LOC100487510
gene id: 8364:LOC100487510
uniprot id: A0A8J0SWP6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:nfatc3
gene id: 8364:nfatc3
uniprot id: A0A803K607
uniprot id: B4F6V2
names: Subcellular Location Annotation
messages: Nucleus

8364:garem1
gene id: 8364:garem1
uniprot id: A0A8J0QPD6
uniprot id: A0A8J1JNQ0
uniprot id: A0A8J1JNQ3
uniprot id: F7ETG3
names: Similarity
messages: Belongs to the GAREM family.

8364:gorasp1
gene id: 8364:gorasp1
uniprot id: Q6GLD6
names: Similarity
messages: Belongs to the GORASP family.

8364:LOC100495056
gene id: 8364:LOC100495056
uniprot id: A0A8J1JLY6
uniprot id: A0A8J1JLZ0
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:hars
gene id: 8364:hars
uniprot id: A0A8J1J9R2
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

8364:LOC116409633
gene id: 8364:LOC116409633
uniprot id: A0A8J1J8M8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:LOC100485006
gene id: 8364:LOC100485006
uniprot id: A0A8J1JLF3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC108644811
gene id: 8364:LOC108644811
uniprot id: A0A8J0T0M0
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:adamts19
gene id: 8364:adamts19
uniprot id: A0A8J1IT83
uniprot id: F7B874
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:pla2g4f
gene id: 8364:pla2g4f
uniprot id: F6TFZ5
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

8364:ptp4a2
gene id: 8364:ptp4a2
uniprot id: Q28IC6
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

8364:celsr2
gene id: 8364:celsr2
uniprot id: A0A6I8PZ44
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor that may have an important role in cell/cell signaling during nervous system formation.

8364:bax
gene id: 8364:bax
uniprot id: Q6P4Y4
names: Similarity
messages: Belongs to the Bcl-2 family.

8364:glud1
gene id: 8364:glud1
uniprot id: Q5XGI4
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

8364:sult1a1
gene id: 8364:sult1a1
uniprot id: Q6P8G4
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8364:arf4
gene id: 8364:arf4
uniprot id: Q5BJ34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

8364:LOC105945568
gene id: 8364:LOC105945568
uniprot id: A0A6I8QVZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:grin2d
gene id: 8364:grin2d
uniprot id: A0A8J1JX42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8364:hoxb2
gene id: 8364:hoxb2
uniprot id: A0A6I8PJW3
names: Subcellular Location Annotation
messages: Nucleus

8364:alkal1
gene id: 8364:alkal1
uniprot id: A0A803JK80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALKAL family.
messages: Secreted

8364:LOC100498055
gene id: 8364:LOC100498055
uniprot id: A0A8J1JW55
uniprot id: F6YPP8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

8364:nfia
gene id: 8364:nfia
uniprot id: A0A6I8RQ42
uniprot id: A0A6I8SYU7
uniprot id: A0A8J0R314
uniprot id: A0A8J0R3N8
uniprot id: A0A8J1JIA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

8364:LOC100486008
gene id: 8364:LOC100486008
uniprot id: A0A1B8Y809
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:cacna2d2
gene id: 8364:cacna2d2
uniprot id: A0A6I8S0M4
uniprot id: F7C1C8
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

8364:LOC105948070
gene id: 8364:LOC105948070
uniprot id: A0A8J1IM26
uniprot id: A0A8J1IM29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIP1 family.
messages: Nucleus

8364:LOC105946701
gene id: 8364:LOC105946701
uniprot id: A0A8J1JUQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudE family.
messages: centrosome
messages: spindle

8364:LOC100485683
gene id: 8364:LOC100485683
uniprot id: A0A8J1IPV5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:slc38a8
gene id: 8364:slc38a8
uniprot id: Q28I47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Membrane
messages: Putative sodium-dependent amino acid/proton antiporter.

8364:mrpl23
gene id: 8364:mrpl23
uniprot id: F6QVF9
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

8364:cer1
gene id: 8364:cer1
uniprot id: Q07G34
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DAN family.
messages: Expressed in the anterior endomesoderm of the early gastrula with expression expanded laterally around the margin at the endoderm/mesoderm boundary.
messages: Expressed in the gastrula stage of embryos but becomes absent by late neurula stage.
messages: Inhibits wnt, nodal/nr-1 and bmp signaling in the embryo to promote head formation and anterior neural induction. Within the endoderm, acts as an essential mediator of nodal/nr-1-induced cardiogenesis in the overlying mesoderm (By similarity).
messages: Secreted
messages: The long chain interacts with nodal/nr-1, bmp4 and wnt8, thereby inhibiting their function. The short chain interacts with nodal/nr-1 but not bmp4 or wnt8 (By similarity).

8364:eva1b
gene id: 8364:eva1b
uniprot id: Q6GLB8
names: Similarity
messages: Belongs to the EVA1 family.

8364:rab43
gene id: 8364:rab43
uniprot id: Q28GE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane

8364:LOC100495370
gene id: 8364:LOC100495370
uniprot id: A0A803J406
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

8364:dync1li1
gene id: 8364:dync1li1
uniprot id: A0A8J0SQ42
uniprot id: Q0V9Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

8364:ntsr2
gene id: 8364:ntsr2
uniprot id: A0A6I8S4R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:stx10
gene id: 8364:stx10
uniprot id: F6RZC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

8364:nsun4
gene id: 8364:nsun4
uniprot id: Q66KI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Involved in mitochondrial ribosome large subunit biogenesis.
messages: Mitochondrion

8364:gem
gene id: 8364:gem
uniprot id: F7CID2
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

8364:LOC116411741
gene id: 8364:LOC116411741
uniprot id: A0A8J1JTS6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:LOC116409814
gene id: 8364:LOC116409814
uniprot id: Q28J31
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:aup1
gene id: 8364:aup1
uniprot id: A9ULG4
uniprot id: B7ZTU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AUP1 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Membrane
messages: Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (By similarity). Plays a role in lipid droplet formation (By similarity). Induces lipid droplet clustering (By similarity).

8364:LOC101734514
gene id: 8364:LOC101734514
uniprot id: A0A8J1K0Z9
names: Similarity
messages: Belongs to the leprecan family.

8364:slc6a4l
gene id: 8364:slc6a4l
uniprot id: F7B9G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8364:vti1b
gene id: 8364:vti1b
uniprot id: Q28GI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

8364:ces3.7
gene id: 8364:ces3.7
uniprot id: A0A8J0QUC2
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

8364:parp14.2
gene id: 8364:parp14.2
uniprot id: A0A8J0QZ24
names: Similarity
messages: Belongs to the ARTD/PARP family.

8364:panx1
gene id: 8364:panx1
uniprot id: B3DLA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

8364:rgs12
gene id: 8364:rgs12
uniprot id: A0A8J0S6P2
uniprot id: A0A8J0SD08
uniprot id: F6UAR3
names: Subcellular Location Annotation
messages: Cytoplasm

8364:yipf4
gene id: 8364:yipf4
uniprot id: A0A803JAS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:tns2
gene id: 8364:tns2
uniprot id: A0A6I8RKL4
uniprot id: F7BHL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

8364:tinagl1
gene id: 8364:tinagl1
uniprot id: F6U204
names: Similarity
messages: Belongs to the peptidase C1 family.

8364:LOC448216
gene id: 8364:LOC448216
uniprot id: A0A803KKA8
names: Similarity
messages: Belongs to the peptidase C1 family.

8364:gna15
gene id: 8364:gna15
uniprot id: F6TB92
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

8364:fbl
gene id: 8364:fbl
uniprot id: Q6P623
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

8364:adat2
gene id: 8364:adat2
uniprot id: A0A8J1JKX1
uniprot id: Q0P4H0
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
messages: Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

8364:stip1
gene id: 8364:stip1
uniprot id: Q6P302
names: Subcellular Location Annotation
messages: Cytoplasm

8364:kdm4a
gene id: 8364:kdm4a
uniprot id: A0A803KK86
uniprot id: A9UMG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM3 histone demethylase family.
messages: Nucleus

8364:LOC116410220
gene id: 8364:LOC116410220
uniprot id: A0A803J763
names: Subcellular Location Annotation
messages: Cytoplasm

8364:LOC101732303
gene id: 8364:LOC101732303
uniprot id: A0A8J0QW11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:med6
gene id: 8364:med6
uniprot id: A0A803KKY6
uniprot id: B3DLE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8364:mindy4b
gene id: 8364:mindy4b
uniprot id: A0A8J0SU92
uniprot id: A0A8J1JK21
uniprot id: A0A8J1JMH0
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

8364:sfrp2
gene id: 8364:sfrp2
uniprot id: Q6P8B8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:clic5
gene id: 8364:clic5
uniprot id: A0A6I8QJB8
uniprot id: Q6DF44
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

8364:cyp2a6.4
gene id: 8364:cyp2a6.4
uniprot id: A0A8J0R446
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:mdga2
gene id: 8364:mdga2
uniprot id: A0A6I8QW44
uniprot id: A0A8J1IP04
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:dcp1a
gene id: 8364:dcp1a
uniprot id: F7BGM2
names: Similarity
messages: Belongs to the DCP1 family.

8364:LOC100170560
gene id: 8364:LOC100170560
uniprot id: A0A803KKQ6
uniprot id: F7DSB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

8364:txnrd3
gene id: 8364:txnrd3
uniprot id: A0A8J0QHH9
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

8364:rpl5
gene id: 8364:rpl5
uniprot id: A0A803KLT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

8364:pik3r1
gene id: 8364:pik3r1
uniprot id: A0A6I8S9W3
uniprot id: A0A6I8SVB1
uniprot id: A0A8J0QZS8
uniprot id: F6Z0J4
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

8364:LOC100493204
gene id: 8364:LOC100493204
uniprot id: A0A803JM10
names: Similarity
messages: Belongs to the pectinacetylesterase family. Notum subfamily.

8364:farsb
gene id: 8364:farsb
uniprot id: A0A8J1JKK6
uniprot id: Q5EBG3
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

8364:LOC100494358
gene id: 8364:LOC100494358
uniprot id: F6R811
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

8364:ppp1r35
gene id: 8364:ppp1r35
uniprot id: A0A8J1JC89
uniprot id: A0A8J1JC91
uniprot id: A0A8J1JEP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP1R35 family.
messages: centriole

8364:ppp4r3a
gene id: 8364:ppp4r3a
uniprot id: A0A8J0R437
uniprot id: F6YDV8
names: Similarity
messages: Belongs to the SMEK family.

8364:lpin3
gene id: 8364:lpin3
uniprot id: A0A8J0QIB9
uniprot id: A0A8J1IXL4
uniprot id: F7DXS7
names: Similarity
messages: Belongs to the lipin family.

8364:pafah1b1
gene id: 8364:pafah1b1
uniprot id: Q6NZH4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Can self-associate. Component of the cytosolic PAF-AH (I) heterotetrameric enzyme, which is composed of PAFAH1B1 (beta), PAFAH1B2 (alpha2) and PAFAH1B3 (alpha1) subunits. The catalytic activity of the enzyme resides in the alpha1 (PAFAH1B3) and alpha2 (PAFAH1B2) subunits, whereas the beta subunit (PAFAH1B1) has regulatory activity. Trimer formation is not essential for the catalytic activity (By similarity). Interacts with dynein, dynactin, nde1 and ndel1.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in the PAF inactivation (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
messages: centrosome
messages: cytoskeleton

8364:LOC105946956
gene id: 8364:LOC105946956
uniprot id: A0A8J1J8E9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:nfatc2
gene id: 8364:nfatc2
uniprot id: A0A6I8QE36
uniprot id: A0A6I8QTC7
uniprot id: A0A6I8S1Y5
uniprot id: A0A8J0QIL1
uniprot id: A0A8J0R830
uniprot id: A0A8J1IX39
names: Subcellular Location Annotation
messages: Nucleus

8364:ints13
gene id: 8364:ints13
uniprot id: A0A803J8A1
uniprot id: A0A8J1J750
uniprot id: Q6DIK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the asunder family.
messages: Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing (By similarity). Plays a role in gastrulation and early embryogenesis (By similarity).
messages: Cytoplasm
messages: Nucleus

8364:sec24d
gene id: 8364:sec24d
uniprot id: A0A7D9NJM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

8364:LOC100497753
gene id: 8364:LOC100497753
uniprot id: A0A8J0QUS8
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Membrane
messages: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.

8364:cep44
gene id: 8364:cep44
uniprot id: A0A6I8PNL3
uniprot id: Q0P4I1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds to centriolar microtubules.
messages: Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall. Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome.
messages: Midbody
messages: centriole
messages: centrosome
messages: spindle pole

8364:mrpl34
gene id: 8364:mrpl34
uniprot id: A0A6I8Q561
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

8364:trpv4l.4
gene id: 8364:trpv4l.4
uniprot id: A0A6I8SB12
names: Subcellular Location Annotation
messages: Membrane

8364:LOC116408401
gene id: 8364:LOC116408401
uniprot id: A0A8J1J203
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:scml2
gene id: 8364:scml2
uniprot id: A0A8J1J2C4
uniprot id: F6YNN0
uniprot id: Q0IHT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

8364:LOC101732638
gene id: 8364:LOC101732638
uniprot id: B5DDY3
uniprot id: Q28DR4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by pak2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

8364:hdx
gene id: 8364:hdx
uniprot id: A0A6I8PJ98
uniprot id: A0A8J0SXF1
names: Subcellular Location Annotation
messages: Nucleus

8364:sox9
gene id: 8364:sox9
uniprot id: Q6F2E7
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in both male and female gonads from after metamorphosis through to adult stages. In the testis, expression is restricted to the supporting Sertoli-like cells. Conversely in the ovary, expression is localized to primary oocytes (at protein level). In developing limbs, expressed before chrondrocytes form (stage 52 tadpoles) and throughout the cartilaginous anlagen until stage 56, after which expression ceases in the enlarged cells of the diaphysis. At later stages, expression continues in the chondrocytes of the epiphysis and metaphysis, and weak expression is seen in most of the diaphysis.
messages: Interacts with the sumoylation factors ube2i/ubc9 and sumo1.
messages: Nucleus
messages: Sumoylated. Lys-370 is the major site of sumoylation, although sumoylation at Lys-61 also occurs. Sumoylation plays a key role in regulating formation of the neural crest and otic placode (By similarity).
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor that plays a key role in chondrocytes differentiation and skeletal development. Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including COL2A1. Plays a central role in successive steps of chondrocyte differentiation. Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis. Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes. Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells. Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation. In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells (By similarity). Unlikely to play a role in sex determination but may function during testicular and ovarian differentiation (PubMed:18692165, PubMed:18816826).

8364:samd4a
gene id: 8364:samd4a
uniprot id: A0A8J0SVX7
uniprot id: Q0IHW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a translational repressor.
messages: Belongs to the SMAUG family.
messages: Cytoplasm
messages: dendrite
messages: synaptosome

8364:u2af2
gene id: 8364:u2af2
uniprot id: Q28EQ0
uniprot id: Q6NVN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Necessary for the splicing of pre-mRNA.
messages: Nucleus

8364:ythdf1
gene id: 8364:ythdf1
uniprot id: A0A803K695
uniprot id: Q6P1V5
names: Function
names: Similarity
messages: Belongs to the YTHDF family.
messages: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.

8364:ppargc1b
gene id: 8364:ppargc1b
uniprot id: A0A6I8Q4X1
names: Subcellular Location Annotation
messages: Nucleus

8364:mpped1
gene id: 8364:mpped1
uniprot id: A0A803K3V5
names: Similarity
messages: Belongs to the UPF0046 family.

8364:sema6d
gene id: 8364:sema6d
uniprot id: A0A6I8RF68
uniprot id: A0A6I8RP18
uniprot id: A0A6I8SE23
uniprot id: F7A6P1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:hpf1
gene id: 8364:hpf1
uniprot id: A0A8J0T4L3
uniprot id: F6ZKY4
names: Similarity
messages: Belongs to the HPF1 family.

8364:rp2
gene id: 8364:rp2
uniprot id: F7BFF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.
messages: Belongs to the TBCC family.
messages: Cell membrane
messages: Membrane

8364:mrpl20
gene id: 8364:mrpl20
uniprot id: A4IH16
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.

8364:kcnk12
gene id: 8364:kcnk12
uniprot id: A0A8J1JLL9
uniprot id: F6WH56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

8364:LOC116410983
gene id: 8364:LOC116410983
uniprot id: A0A803JX41
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:myo10.2
gene id: 8364:myo10.2
uniprot id: A0A8J1IVK0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:ap1s2
gene id: 8364:ap1s2
uniprot id: A0A6I8PLS9
uniprot id: A0A803K3K6
uniprot id: A0A8J0SD09
uniprot id: A0A8J0SEX3
uniprot id: A0A8J0SG10
uniprot id: Q28C71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

8364:LOC116411032
gene id: 8364:LOC116411032
uniprot id: A0A8J1JLA1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC116411574
gene id: 8364:LOC116411574
uniprot id: A0A8J1JSE2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:alg9
gene id: 8364:alg9
uniprot id: A0A6I8SNQ0
uniprot id: A0A8J0QLI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:septin7
gene id: 8364:septin7
uniprot id: A0A6I8QML0
uniprot id: A0A8J0R2F5
uniprot id: A0A8J0R5E6
uniprot id: A0A8J1JNC0
uniprot id: A0A8J1JNC1
uniprot id: A0A8J1JS21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Midbody
messages: cilium axoneme
messages: kinetochore
messages: spindle

8364:ramp3
gene id: 8364:ramp3
uniprot id: A9ULG5
names: Similarity
messages: Belongs to the RAMP family.

8364:LOC116406431
gene id: 8364:LOC116406431
uniprot id: A0A8J1IPM9
names: Similarity
messages: Belongs to the cyclin family.

8364:tmem267
gene id: 8364:tmem267
uniprot id: A0A6I8RD39
names: Subcellular Location Annotation
messages: Membrane

8364:atp5me
gene id: 8364:atp5me
uniprot id: B3DLE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase e subunit family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

8364:taar3p
gene id: 8364:taar3p
uniprot id: A0A1B8XU38
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:LOC100497187
gene id: 8364:LOC100497187
uniprot id: A0A8J0QSH5
uniprot id: A0A8J0SQS3
names: Similarity
messages: Belongs to the CRISP family.

8364:LOC116408030
gene id: 8364:LOC116408030
uniprot id: A0A8J1J1L6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

8364:znf532
gene id: 8364:znf532
uniprot id: A0A6I8QI25
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

8364:dpp3
gene id: 8364:dpp3
uniprot id: F7DZ42
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M49 family.
messages: Binds 1 zinc ion per subunit.

8364:b3gnt2
gene id: 8364:b3gnt2
uniprot id: F7EIV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:atp2c2
gene id: 8364:atp2c2
uniprot id: Q0P4N5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:LOC116408600
gene id: 8364:LOC116408600
uniprot id: A0A8J1J607
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:ost4
gene id: 8364:ost4
uniprot id: A0A8J1JIZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:cmpk2
gene id: 8364:cmpk2
uniprot id: A0A8J1JLK0
uniprot id: F6R5I8
names: Similarity
messages: Belongs to the thymidylate kinase family.

8364:traf4
gene id: 8364:traf4
uniprot id: Q6DEV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

8364:cep55
gene id: 8364:cep55
uniprot id: A0A6I8QK96
uniprot id: A0A8J0R4U1
names: Subcellular Location Annotation
messages: Cytoplasm

8364:usb1
gene id: 8364:usb1
uniprot id: A0A8J1JGE0
uniprot id: B1WBH1
uniprot id: F6SDY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. USB1 family.
messages: Nucleus
messages: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.

8364:qsox2
gene id: 8364:qsox2
uniprot id: B2GUM8
names: Function
names: Similarity
messages: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
messages: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.

8364:cdk6
gene id: 8364:cdk6
uniprot id: F6YRJ4
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:gabarapl2
gene id: 8364:gabarapl2
uniprot id: F7B652
names: Similarity
messages: Belongs to the ATG8 family.

8364:cyp1b1
gene id: 8364:cyp1b1
uniprot id: A0A6I8SJ30
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:LOC116407787
gene id: 8364:LOC116407787
uniprot id: A0A8J1IYU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8364:smarca4
gene id: 8364:smarca4
uniprot id: F7EG86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

8364:LOC100496657
gene id: 8364:LOC100496657
uniprot id: A0A8J0R0S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:rragc
gene id: 8364:rragc
uniprot id: A0A8J0SCQ4
uniprot id: Q28DJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

8364:prkca
gene id: 8364:prkca
uniprot id: A0A8J1IWQ9
uniprot id: A0A8J1IZY1
uniprot id: A0JM65
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion membrane
messages: Nucleus

8364:slc7a6
gene id: 8364:slc7a6
uniprot id: Q28I80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Cell membrane
messages: Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.
messages: Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux routeby exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis. Also exchanges L-arginine with L-lysine in a sodium-independent manner. The transport mechanism is electroneutral and operates with a stoichiometry of 1: 1 (By similarity). Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration (By similarity). May mediate transport of ornithine in retinal pigment epithelial (RPE) cells (By similarity). May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte (By similarity).

8364:lgalsl
gene id: 8364:lgalsl
uniprot id: Q6NVI7
names: Caution
names: Function
messages: Does not bind lactose, and may not bind carbohydrates.
messages: Most of the residues in the galectin domain that have been shown to be critical for carbohydrate-binding in other galectins are not conserved.

8364:LOC116409643
gene id: 8364:LOC116409643
uniprot id: A0A8J1JC56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100496865
gene id: 8364:LOC100496865
uniprot id: A0A7D9NK97
names: Similarity
messages: Belongs to the Bcl-2 family.

8364:LOC100489050
gene id: 8364:LOC100489050
uniprot id: A0A8J1INS1
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:nrdc
gene id: 8364:nrdc
uniprot id: F7AJT5
names: Similarity
messages: Belongs to the peptidase M16 family.

8364:timm10
gene id: 8364:timm10
uniprot id: A0A8J1J8X0
uniprot id: Q6P321
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Heterohexamer; composed of 3 copies of TIMM9 and 3 copies of TIMM10/TIM10A, named soluble 70 kDa complex. The complex forms a 6-bladed alpha-propeller structure and associates with the TIMM22 component of the TIM22 complex. Interacts with multi-pass transmembrane proteins in transit (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM10 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

8364:cth
gene id: 8364:cth
uniprot id: Q6P849
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

8364:esx1
gene id: 8364:esx1
uniprot id: A0A6I8RMI7
names: Subcellular Location Annotation
messages: Nucleus

8364:selenos
gene id: 8364:selenos
uniprot id: Q5I030
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selenoprotein S family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner (By similarity).

8364:ppp6r3
gene id: 8364:ppp6r3
uniprot id: A0A6I8QWR7
uniprot id: A0A8J0SLV7
uniprot id: A0A8J1JHE5
uniprot id: F7EQL9
uniprot id: Q0P4P8
names: Similarity
messages: Belongs to the SAPS family.

8364:LOC108645256
gene id: 8364:LOC108645256
uniprot id: A0A6I8QUK5
uniprot id: A0A8J1JEK4
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:cass4
gene id: 8364:cass4
uniprot id: A0A6I8QNC3
uniprot id: A0A8J1IXL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

8364:dlgap5
gene id: 8364:dlgap5
uniprot id: Q6NVT0
names: Similarity
messages: Belongs to the SAPAP family.

8364:trappc2l
gene id: 8364:trappc2l
uniprot id: Q5M8X5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: perinuclear region

8364:arf6
gene id: 8364:arf6
uniprot id: A0A803KKR5
uniprot id: Q6P1V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cell membrane
messages: Cleavage furrow
messages: Endosome membrane
messages: Midbody ring
messages: Recycling endosome membrane
messages: filopodium membrane
messages: ruffle

8364:uba3
gene id: 8364:uba3
uniprot id: A0A8J0SIX4
uniprot id: B1H132
uniprot id: B5DFR3
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.

8364:ccdc134
gene id: 8364:ccdc134
uniprot id: Q28F39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC134 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: In extracellular secreted form, promotes proliferation and activation of T cells, suggesting a cytokine-like function. May inhibit ERK and JNK signaling activity and suppress cell migration and invasion activity. Has a critical role in the regulation of osteogenesis and bone development.
messages: In the nucleus, enhances activity of the PCAF histone acetyltransferase (HAT) complex.
messages: Nucleus
messages: Secreted

8364:mfsd6l
gene id: 8364:mfsd6l
uniprot id: F6RLI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

8364:LOC116410504
gene id: 8364:LOC116410504
uniprot id: A0A8J1JH63
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natural cytotoxicity receptor (NCR) family.
messages: Cell membrane
messages: Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6.
messages: Membrane

8364:LOC116407752
gene id: 8364:LOC116407752
uniprot id: A0A8J1IYL3
names: Similarity
messages: Belongs to the ARTD/PARP family.

8364:flcn
gene id: 8364:flcn
uniprot id: Q5M7Q1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the folliculin family.
messages: Component of the lysosomal folliculin complex (LFC).
messages: GTPase-activating activity is inhibited in the folliculin complex (LFC), which stabilizes the GDP-bound state of RagA/RRAGA (or RagB/RRAGB), because Arg-164 is located far from the RagC/RRAGC or RagD/RRAGD nucleotide pocket. Disassembly of the LFC complex upon amino acid restimulation liberates the GTPase-activating activity.
messages: Lysosome membrane
messages: Multi-functional protein, involved in both the cellular response to amino acid availability and in the regulation of glycolysis. GTPase-activating protein that plays a key role in the cellular response to amino acid availability through regulation of the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors tfeb and tfe3. Activates mTORC1 by acting as a GTPase-activating protein: specifically stimulates GTP hydrolysis by RagC/RRAGC or RagD/RRAGD, promoting the conversion to the GDP-bound state of RagC/RRAGC or RagD/RRAGD, and thereby activating the kinase activity of mTORC1. The GTPase-activating activity is inhibited during starvation and activated in presence of nutrients. Acts as a key component for non-canonical mTORC1-dependent control of the MiT/TFE factors tfeb and tfe3, while it is not involved in mTORC1-dependent phosphorylation of canonical RPS6KB1/S6K1 and EIF4EBP1/4E-BP1. In low-amino acid conditions, the lysosomal folliculin complex (LFC) is formed on the membrane of lysosomes, which inhibits the GTPase-activating activity of flcn, inactivates mTORC1 and maximizes nuclear translocation of tfeb and tfe3. Upon amino acid restimulation, RagA/RRAGA (or RagB/RRAGB) nucleotide exchange promotes disassembly of the LFC complex and liberates the GTPase-activating activity of flcn, leading to activation of mTORC1 and subsequent cytoplasmic retention of tfeb and tfe3. Required for the exit of hematopoietic stem cell from pluripotency by promoting mTOR-dependent cytoplasmic retention of tfe3, thereby increasing Wnt signaling. Acts as an inhibitor of browning of adipose tissue by regulating mTOR-dependent cytoplasmic retention of tfe3. In response to flow stress, regulates STK11/LKB1 accumulation and mTORC1 activation through primary cilia. Required for starvation-induced perinuclear clustering of lysosomes by promoting association of rilp with its effector rab34. Involved in the control of embryonic stem cells differentiation; together with lamtor1…
messages: Nucleus
messages: centrosome
messages: cilium
messages: cytosol
messages: spindle

8364:LOC100491830
gene id: 8364:LOC100491830
uniprot id: F6V0M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

8364:siah1
gene id: 8364:siah1
uniprot id: A0A6I8S8J7
uniprot id: A0A803KKK3
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

8364:LOC105946367
gene id: 8364:LOC105946367
uniprot id: A0A8J0SB88
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:tmtops.2
gene id: 8364:tmtops.2
uniprot id: F7EFF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

8364:nip7
gene id: 8364:nip7
uniprot id: A4QND5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIP7 family.
messages: Monomer. Interacts with pre-ribosome complex. May bind to RNA. Interacts with NOL8. Interacts with FTSJ3 (By similarity).
messages: Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

8364:top3b
gene id: 8364:top3b
uniprot id: A0A6I8Q2R6
uniprot id: A0A8J0QA03
uniprot id: A0A8J0S6U3
uniprot id: B1H2R2
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

8364:nme5
gene id: 8364:nme5
uniprot id: Q0IHR2
names: Similarity
messages: Belongs to the NDK family.

8364:tubgcp3
gene id: 8364:tubgcp3
uniprot id: A0A8J0SBE2
uniprot id: F6YJC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

8364:mindy4
gene id: 8364:mindy4
uniprot id: A0A1B8Y9Y6
uniprot id: Q0VA42
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
messages: Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

8364:pabpc1l
gene id: 8364:pabpc1l
uniprot id: Q6DEY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds and protects the poly(A) tail of mRNA with or without an AU-rich element (ARE) and prevents mRNA deadenylation. Stimulates the translation of mRNAs to which it is bound during early development (By similarity).
messages: Cytoplasm
messages: Interacts with dazl in an RNA-independent manner. The C-terminus can self-associate and also interact with the C-terminus of pabpc1, independently of RNA. RRM 1 and RRM 2 interact with both eif4g1 and paip1, and the C-terminus also interacts with paip1. Prior to oocyte maturation, found in a complex with dazl and pum2 proteins and spdy1 mRNA; pum2 dissociates from the complex during maturation. Interacts with the translation termination factor sup35/erf3 (By similarity).

8364:MGC89174
gene id: 8364:MGC89174
uniprot id: A0A803KIN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:LOC100496467
gene id: 8364:LOC100496467
uniprot id: A0A8J0QR79
names: Subcellular Location Annotation
messages: Membrane

8364:snapc3
gene id: 8364:snapc3
uniprot id: A0A8J1ILL6
uniprot id: F6TAI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAPC3/SRD2 family.
messages: Nucleus
messages: Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.
messages: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

8364:slc29a3
gene id: 8364:slc29a3
uniprot id: A0A8J1JRM4
uniprot id: A0A8J1JRN7
uniprot id: A4IFW1
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Lateral cell membrane
messages: Membrane

8364:eya1
gene id: 8364:eya1
uniprot id: A0A6I8QRJ9
uniprot id: A0A6I8QT06
uniprot id: A0A6I8R4E3
uniprot id: A0A8J0SUX9
uniprot id: A0A8J0SUY4
uniprot id: A0A8J0T1Y7
uniprot id: A0A8J0T4C4
uniprot id: A0A8J0T4C9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

8364:hscb
gene id: 8364:hscb
uniprot id: A0A8J0PLS4
uniprot id: A0A8J0SU96
uniprot id: Q0V9B2
names: Similarity
messages: Belongs to the HscB family.

8364:LOC100494799
gene id: 8364:LOC100494799
uniprot id: A0A6I8QHS4
uniprot id: A0A6I8QVF2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

8364:LOC100492375
gene id: 8364:LOC100492375
uniprot id: A0A8J1IRH8
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

8364:LOC100494798
gene id: 8364:LOC100494798
uniprot id: A0A8J0QMF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100495033
gene id: 8364:LOC100495033
uniprot id: A0A8J0R3E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:p4ha2
gene id: 8364:p4ha2
uniprot id: A0A6I8SPS1
uniprot id: A0A8J0SI76
uniprot id: Q66KA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

8364:nab2
gene id: 8364:nab2
uniprot id: B0JZC9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

8364:ptprq
gene id: 8364:ptprq
uniprot id: A0A8J1JA42
uniprot id: A0A8J1JA47
uniprot id: A0A8J1JA50
uniprot id: A0A8J1JCL2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.

8364:hs3st5
gene id: 8364:hs3st5
uniprot id: F6V088
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8364:far1
gene id: 8364:far1
uniprot id: A0A8J0SSV3
uniprot id: A0A8J0SZW0
uniprot id: A4IGR0
uniprot id: F6VHQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

8364:grin3a
gene id: 8364:grin3a
uniprot id: F7E003
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8364:rbp4l
gene id: 8364:rbp4l
uniprot id: A4IGI2
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

8364:LOC116412313
gene id: 8364:LOC116412313
uniprot id: A0A8J1JZ18
names: Subcellular Location Annotation
messages: Membrane

8364:psap
gene id: 8364:psap
uniprot id: A0A8J1JSW0
uniprot id: B1H2K4
uniprot id: Q28D55
names: Subcellular Location Annotation
messages: Secreted

8364:apcdd1
gene id: 8364:apcdd1
uniprot id: Q6DF34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APCDD1 family.
messages: Cell membrane
messages: Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin (By similarity).

8364:arglu1
gene id: 8364:arglu1
uniprot id: Q6P2W5
names: Similarity
messages: Belongs to the UPF0430 family.

8364:def8
gene id: 8364:def8
uniprot id: A0A8J0SI38
uniprot id: Q6DJB3
names: Function
names: Similarity
messages: Belongs to the DEF8 family.
messages: Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption.

8364:cpa6
gene id: 8364:cpa6
uniprot id: B0BM52
names: Similarity
messages: Belongs to the peptidase M14 family.

8364:LOC116407770
gene id: 8364:LOC116407770
uniprot id: A0A8J1IVJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8364:prkar2b
gene id: 8364:prkar2b
uniprot id: A0A8J0SJU0
uniprot id: F7EI83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

8364:glt8d1
gene id: 8364:glt8d1
uniprot id: A0A803JK18
uniprot id: A0A8J1JDI2
uniprot id: A0A8J1JH13
uniprot id: B7ZTW3
uniprot id: Q28I33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Membrane

8364:LOC108646263
gene id: 8364:LOC108646263
uniprot id: A0A8J0SSP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:atp6ap1l
gene id: 8364:atp6ap1l
uniprot id: A0A6I8PRK7
names: Similarity
messages: Belongs to the vacuolar ATPase subunit S1 family.

8364:nek6
gene id: 8364:nek6
uniprot id: Q6DIX9
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC116410995
gene id: 8364:LOC116410995
uniprot id: A0A8J1JPS4
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:serpinf2
gene id: 8364:serpinf2
uniprot id: A0A8J0QQ54
names: Similarity
messages: Belongs to the serpin family.

8364:taf2
gene id: 8364:taf2
uniprot id: A0A8J0SRH2
uniprot id: A0A8J0T413
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF2 family.
messages: Nucleus

8364:gngt2
gene id: 8364:gngt2
uniprot id: A4IHM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8364:LOC100487632
gene id: 8364:LOC100487632
uniprot id: A0A6I8S7P0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:LOC116407728
gene id: 8364:LOC116407728
uniprot id: A0A803JEE7
uniprot id: A0A8J1IV59
uniprot id: A0A8J1IV60
uniprot id: A0A8J1IV63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8364:ovol1
gene id: 8364:ovol1
uniprot id: A0A803K9N2
uniprot id: A0A8J0SMU2
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC116412348
gene id: 8364:LOC116412348
uniprot id: A0A8J1JZB3
names: Subcellular Location Annotation
messages: Membrane

8364:mrps11
gene id: 8364:mrps11
uniprot id: B5DFS9
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

8364:nt5e
gene id: 8364:nt5e
uniprot id: A0A6I8T2Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-nucleotidase family.
messages: Membrane

8364:cilp
gene id: 8364:cilp
uniprot id: A0A8J1JB66
uniprot id: F6U172
names: Subcellular Location Annotation
messages: extracellular matrix

8364:b9d1
gene id: 8364:b9d1
uniprot id: Q5BJ61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the B9D family.
messages: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).
messages: Part of the tectonic-like complex (also named B9 complex).
messages: cilium basal body

8364:utp23
gene id: 8364:utp23
uniprot id: Q28C23
names: Subcellular Location Annotation
messages: nucleolus

8364:LOC100170420
gene id: 8364:LOC100170420
uniprot id: F6ZMN7
names: Similarity
messages: Belongs to the thioredoxin family.

8364:cops8
gene id: 8364:cops8
uniprot id: Q6P637
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN8 family.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity).
messages: Component of the CSN complex, probably composed of cops1, cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
messages: Cytoplasm
messages: Nucleus

8364:arl8b
gene id: 8364:arl8b
uniprot id: A0A6I8SH59
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

8364:scnn1gl
gene id: 8364:scnn1gl
uniprot id: A0A8J0T2F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

8364:smug1
gene id: 8364:smug1
uniprot id: A4IGM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.
messages: Nucleus

8364:isyna1
gene id: 8364:isyna1
uniprot id: B0BM05
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

8364:aldh6a1
gene id: 8364:aldh6a1
uniprot id: A0A6I8SP15
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

8364:aldh4a1
gene id: 8364:aldh4a1
uniprot id: A4QNJ0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

8364:ep300
gene id: 8364:ep300
uniprot id: A0A8J0QK55
uniprot id: A0A8J0R367
uniprot id: A0A8J0R3J0
uniprot id: F7DX95
names: Subcellular Location Annotation
messages: Cytoplasm

8364:cacna2d1
gene id: 8364:cacna2d1
uniprot id: A1L1E0
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

8364:LOC407755
gene id: 8364:LOC407755
uniprot id: Q75R39
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:tmc7
gene id: 8364:tmc7
uniprot id: A0A6I8Q7D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

8364:LOC100490157
gene id: 8364:LOC100490157
uniprot id: A0A8J0SX76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Nucleus

8364:stra6l.1
gene id: 8364:stra6l.1
uniprot id: A0A8J0SE58
uniprot id: B1H195
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:slc26a2.2
gene id: 8364:slc26a2.2
uniprot id: F7CNJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

8364:LOC116409631
gene id: 8364:LOC116409631
uniprot id: A0A8J1JB19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC101730495
gene id: 8364:LOC101730495
uniprot id: A0A803JG48
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:clptm1l
gene id: 8364:clptm1l
uniprot id: F6TSZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

8364:LOC108645368
gene id: 8364:LOC108645368
uniprot id: A0A8J1JEL5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:t2r50
gene id: 8364:t2r50
uniprot id: Q2AB37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:actr3
gene id: 8364:actr3
uniprot id: Q6P309
names: Similarity
messages: Belongs to the actin family.

8364:smo
gene id: 8364:smo
uniprot id: A0A6I8RRT2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: cilium

8364:npepl1
gene id: 8364:npepl1
uniprot id: Q4VA75
names: Similarity
messages: Belongs to the peptidase M17 family.

8364:slc30a9
gene id: 8364:slc30a9
uniprot id: A0A8J0QFQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Endoplasmic reticulum
messages: Membrane
messages: Mitochondrion membrane
messages: Nucleus

8364:polr1b
gene id: 8364:polr1b
uniprot id: F6ZV36
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.

8364:pou3f4
gene id: 8364:pou3f4
uniprot id: A1L0Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus
messages: Transcriptional activator. Induces neural-specific gene expression to act as a key regulator of neural differentiation (By similarity).

8364:cdk9
gene id: 8364:cdk9
uniprot id: A0A8J0SUC8
uniprot id: A0A8J0SVQ7
uniprot id: Q6GLD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with cyclin-T to form P-TEFb.
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) and SUPT5H.
messages: Nucleus

8364:marchf3
gene id: 8364:marchf3
uniprot id: Q68FA7
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle membrane
messages: E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
messages: Early endosome membrane
messages: The RING-CH-type zinc finger domain is required for E3 ligase activity.

8364:atrn
gene id: 8364:atrn
uniprot id: F6QBN7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:gpr156
gene id: 8364:gpr156
uniprot id: A0A6I8RZF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

8364:mrps26
gene id: 8364:mrps26
uniprot id: A4IHL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS26 family.
messages: Mitochondrion

8364:polr2j
gene id: 8364:polr2j
uniprot id: Q28CA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.
messages: Nucleus

8364:xpo4
gene id: 8364:xpo4
uniprot id: A0A803K9E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Nucleus

8364:acot2
gene id: 8364:acot2
uniprot id: B0BM61
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

8364:nxpe3l.1
gene id: 8364:nxpe3l.1
uniprot id: A0A8J1JTW4
names: Similarity
messages: Belongs to the NXPE family.

8364:mospd1
gene id: 8364:mospd1
uniprot id: F6PUC4
uniprot id: Q5FVZ0
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100487198
gene id: 8364:LOC100487198
uniprot id: A0A8J1JER7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8364:cdca2
gene id: 8364:cdca2
uniprot id: A0A6I8Q0W4
names: Subcellular Location Annotation
messages: Nucleus

8364:galr1
gene id: 8364:galr1
uniprot id: A9ULC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8364:ptges3
gene id: 8364:ptges3
uniprot id: Q5U4Z0
names: Similarity
messages: Belongs to the p23/wos2 family.

8364:gprin1
gene id: 8364:gprin1
uniprot id: A0A803JRH3
names: Function
messages: May be involved in neurite outgrowth.

8364:desi2
gene id: 8364:desi2
uniprot id: A0A803JJ39
names: Similarity
messages: Belongs to the DeSI family.

8364:fut2
gene id: 8364:fut2
uniprot id: A0A803JXJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 11 family.
messages: Golgi stack membrane
messages: Membrane

8364:cnn2
gene id: 8364:cnn2
uniprot id: Q6NVQ5
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

8364:LOC100495638
gene id: 8364:LOC100495638
uniprot id: A0A6I8S4I7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:erlin1
gene id: 8364:erlin1
uniprot id: Q28DX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex.

8364:eif2s1
gene id: 8364:eif2s1
uniprot id: A0A8J1IL56
uniprot id: Q6GL89
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activity is regulated by phosphorylation at Ser-49 and Ser-52, which stabilizes the eIF-2/GDP/eIF-2B complex and prevents the eIF-2B-mediated exchange of GDP for GTP, thereby preventing the formation of the 43S pre-initiation complex (PIC). This results in the global attenuation of 5' cap-dependent protein synthesis and concomitant translation of ISR-specific mRNAs that contain a short upstream open reading frame (uORF) in their 5' UTR.
messages: Belongs to the eIF-2-alpha family.
messages: Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. EIF2S1/eIF-2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: Phosphorylation at Ser-49 and Ser-52 stabilizes the eIF-2/GDP/eIF-2B complex and prevents GDP/GTP exchange reaction, thus impairing the recycling of eIF-2 between successive rounds of initiation and leading to global inhibition of translation, while concomitantly initiating the preferential translation of integrated stress response (ISR)-specific mRNAs.
messages: Stress granule

8364:dop1a
gene id: 8364:dop1a
uniprot id: A0A8J0QFX9
uniprot id: A0A8J1JI82
uniprot id: F7E089
uniprot id: F7E097
names: Similarity
messages: Belongs to the dopey family.

8364:LOC105946955
gene id: 8364:LOC105946955
uniprot id: A0A8J1J8E8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC116406428
gene id: 8364:LOC116406428
uniprot id: A0A803JF47
names: Similarity
messages: Belongs to the ARTD/PARP family.

8364:or2t27
gene id: 8364:or2t27
uniprot id: A0A6I8PNB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:swi5
gene id: 8364:swi5
uniprot id: A0A8J0STY3
uniprot id: A9UL70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWI5/SAE3 family.
messages: Component of the swi5-sfr1 complex, a complex required for double-strand break repair via homologous recombination.
messages: Component of the swi5-sfr1 complex.
messages: Nucleus

8364:mgmt
gene id: 8364:mgmt
uniprot id: A0A803JLP7
uniprot id: F7AWA8
uniprot id: Q5M799
names: Function
names: Similarity
messages: Belongs to the MGMT family.
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

8364:crygdl.17
gene id: 8364:crygdl.17
uniprot id: A0A8J0SAF9
uniprot id: A0A8J0SD70
uniprot id: A0A8J1JUC7
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:zdhhc9
gene id: 8364:zdhhc9
uniprot id: A4IIG3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8364:h4c3
gene id: 8364:h4c3
uniprot id: B5DDY3
uniprot id: Q28DR4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by pak2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

8364:bloc1s3
gene id: 8364:bloc1s3
uniprot id: A0A6I8S3T2
names: Similarity
messages: Belongs to the BLOC1S3 family.

8364:septin12
gene id: 8364:septin12
uniprot id: A0A6I8RUQ3
uniprot id: Q5BL76
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

8364:rev1
gene id: 8364:rev1
uniprot id: A0A6I8SCC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-Y family.
messages: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
messages: Nucleus

8364:mdm1
gene id: 8364:mdm1
uniprot id: A0A803KI12
uniprot id: A0A8J0S946
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM1 family.
messages: Nucleus
messages: centriole

8364:hsd3b7
gene id: 8364:hsd3b7
uniprot id: A0A7D9NKJ9
names: Similarity
messages: Belongs to the 3-beta-HSD family.

8364:dstyk
gene id: 8364:dstyk
uniprot id: Q67E00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm
messages: May act as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death. May play a role in the embryonic development.

8364:krt12.2
gene id: 8364:krt12.2
uniprot id: A0A1B8Y9F0
names: Similarity
messages: Belongs to the intermediate filament family.

8364:LOC100490887
gene id: 8364:LOC100490887
uniprot id: F6X3Y2
names: Similarity
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

8364:cyb5d2
gene id: 8364:cyb5d2
uniprot id: Q28FI8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome b5 family. MAPR subfamily.
messages: Heme-binding protein which promotes neuronal but not astrocyte differentiation.
messages: Secreted
messages: The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved iron-binding His residues at position 82 and 124.

8364:LOC100488368
gene id: 8364:LOC100488368
uniprot id: F7C991
names: Subcellular Location Annotation
messages: Secreted

8364:vbp1
gene id: 8364:vbp1
uniprot id: A0A8J0SUZ0
uniprot id: F6WTZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

8364:LOC100491180
gene id: 8364:LOC100491180
uniprot id: A0A8J0QUM2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:tmem233
gene id: 8364:tmem233
uniprot id: A0A803J729
uniprot id: A0A803KFJ6
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8364:ppip5k1
gene id: 8364:ppip5k1
uniprot id: A0A6I8PYQ7
uniprot id: A0A6I8Q405
uniprot id: A0A6I8QEX8
uniprot id: A0A6I8QJS1
uniprot id: A0A6I8SNR7
uniprot id: A0A8J0SA36
uniprot id: A0A8J0SGD5
uniprot id: A0A8J0SI09
uniprot id: A0A8J0SSH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

8364:scamp5.2
gene id: 8364:scamp5.2
uniprot id: Q0P4S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

8364:fen1
gene id: 8364:fen1
uniprot id: F7B7H6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Mitochondrion
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

8364:LOC100498329
gene id: 8364:LOC100498329
uniprot id: A0A6I8QAK0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:st6galnac1
gene id: 8364:st6galnac1
uniprot id: A0A8J0R734
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8364:nppb
gene id: 8364:nppb
uniprot id: A0A7D9NLJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

8364:immp2l
gene id: 8364:immp2l
uniprot id: A0A6I8QGE0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family. IMP2 subfamily.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Membrane
messages: Mitochondrion inner membrane

8364:olfm4
gene id: 8364:olfm4
uniprot id: A0A8J0PIV0
uniprot id: A0A8J0SUV0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:crygdl.31
gene id: 8364:crygdl.31
uniprot id: A0A8J0QW79
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:c15orf41
gene id: 8364:c15orf41
uniprot id: Q28HL3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May play a role in erythroid cell differentiation.
messages: Nucleus

8364:asph
gene id: 8364:asph
uniprot id: A0A6I8QPT2
uniprot id: A0A6I8RBX0
uniprot id: A0A6I8S9H0
uniprot id: A0A6I8S9Q9
uniprot id: A0A803JM89
uniprot id: A0A8J0PG59
uniprot id: A0A8J1JMV3
uniprot id: A0A8J1JMV7
uniprot id: A0A8J1JMW1
uniprot id: A0A8J1JMW2
uniprot id: A0A8J1JMW3
uniprot id: A0A8J1JQA1
uniprot id: A0A8J1JQA7
uniprot id: A0A8J1JRJ8
uniprot id: A0A8J1JRK8
uniprot id: A0A8J1JRL5
uniprot id: F6RBK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.
messages: Membrane

8364:LOC100488751
gene id: 8364:LOC100488751
uniprot id: A0A8J0QZ26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

8364:LOC101731654
gene id: 8364:LOC101731654
uniprot id: A0A8J1IPX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:mnx1
gene id: 8364:mnx1
uniprot id: F6TM16
names: Subcellular Location Annotation
messages: Nucleus

8364:ncbp3
gene id: 8364:ncbp3
uniprot id: Q6DFQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export.
messages: Belongs to the NCBP3 family.
messages: Component of an alternative cap-binding complex (CBC) composed of NCBP1/CBP80 and NCBP3.
messages: Cytoplasm
messages: Nucleus

8364:wnt1
gene id: 8364:wnt1
uniprot id: A0A803K040
uniprot id: F6X3B2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8364:scrn3
gene id: 8364:scrn3
uniprot id: A0A8J0T727
uniprot id: F7EB85
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

8364:LOC100488444
gene id: 8364:LOC100488444
uniprot id: A0A803J7U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC101730948
gene id: 8364:LOC101730948
uniprot id: A0A8J0R8D8
names: Similarity
messages: Belongs to the nanos family.

8364:slc35a3.2
gene id: 8364:slc35a3.2
uniprot id: F7D8S5
uniprot id: Q6P651
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8364:atp2c1
gene id: 8364:atp2c1
uniprot id: A0A6I8QSW5
uniprot id: A0A6I8RLL7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:ppfibp2
gene id: 8364:ppfibp2
uniprot id: A0A8J0SMQ1
uniprot id: A0A8J1JER0
uniprot id: A0A8J1JER5
uniprot id: A0A8J1JER9
uniprot id: A0A8J1JES0
uniprot id: A0A8J1JES1
uniprot id: A0A8J1JES5
uniprot id: A0A8J1JES6
uniprot id: A0A8J1JH81
uniprot id: A0A8J1JH85
uniprot id: A0A8J1JI77
uniprot id: A0A8J1JI81
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

8364:LOC116409598
gene id: 8364:LOC116409598
uniprot id: A0A8J1J8K0
names: Subcellular Location Annotation
messages: Membrane

8364:agxt2
gene id: 8364:agxt2
uniprot id: A0A6I8SPU7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

8364:t2r17
gene id: 8364:t2r17
uniprot id: A0A803KK99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:sf3b3
gene id: 8364:sf3b3
uniprot id: A0A6I8Q0Q8
names: Subcellular Location Annotation
messages: Nucleus

8364:cul5
gene id: 8364:cul5
uniprot id: Q0D2D8
names: Similarity
messages: Belongs to the cullin family.

8364:sh2b3
gene id: 8364:sh2b3
uniprot id: A4QN29
names: Similarity
messages: Belongs to the SH2B adapter family.

8364:kpna3
gene id: 8364:kpna3
uniprot id: Q28EX2
names: Similarity
messages: Belongs to the importin alpha family.

8364:LOC101732719
gene id: 8364:LOC101732719
uniprot id: A0A8J0SWB8
names: Subcellular Location Annotation
messages: Membrane

8364:isx
gene id: 8364:isx
uniprot id: A0A803K280
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100490847
gene id: 8364:LOC100490847
uniprot id: A0A8J0QTM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8364:frem2
gene id: 8364:frem2
uniprot id: F6TLU6
names: Similarity
messages: Belongs to the FRAS1 family.

8364:fam155b
gene id: 8364:fam155b
uniprot id: A4IHZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NALF family.
messages: Membrane
messages: Probable component of the NALCN channel complex, a channel that regulates the resting membrane potential and controls neuronal excitability.

8364:LOC101730482
gene id: 8364:LOC101730482
uniprot id: A0A8J1JNJ8
names: Similarity
messages: Belongs to the apolipoprotein L family.

8364:nsun6
gene id: 8364:nsun6
uniprot id: Q66II9
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:lars1
gene id: 8364:lars1
uniprot id: Q5EB29
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

8364:cenpe
gene id: 8364:cenpe
uniprot id: A0A6I8RXX0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8364:slc35b2
gene id: 8364:slc35b2
uniprot id: A0A8J0QG19
uniprot id: Q6P329
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

8364:olfml3
gene id: 8364:olfml3
uniprot id: Q0V9V5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OLFML3 family.
messages: Interacts (via coiled coil domain) with BMP1 and (via olfactomedin-like domain) CHRD.
messages: Secreted
messages: Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid protease BMP1 and its substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation by BMP1 (By similarity).

8364:cul4b
gene id: 8364:cul4b
uniprot id: A0A8J0T4Z3
uniprot id: A0A8J0T621
uniprot id: B2GU90
names: Similarity
messages: Belongs to the cullin family.

8364:gprc5cl1
gene id: 8364:gprc5cl1
uniprot id: Q5M7Q6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:kif24
gene id: 8364:kif24
uniprot id: A0A6I8Q1R6
uniprot id: A0A8J1J1C5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8364:c2cd3
gene id: 8364:c2cd3
uniprot id: A0JM13
names: Function
names: Subcellular Location Annotation
messages: Component of the centrioles that acts as a positive regulator of centriole elongation. Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium. Required for primary cilium formation (By similarity).
messages: centriole
messages: cilium basal body

8364:gria4
gene id: 8364:gria4
uniprot id: A0A6I8Q867
uniprot id: A0A6I8R1Z8
uniprot id: A0A8J1J385
uniprot id: A0A8J1J485
uniprot id: F6T3C9
uniprot id: F6Z2A1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8364:LOC116411017
gene id: 8364:LOC116411017
uniprot id: A0A8J1JL80
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:slx1a
gene id: 8364:slx1a
uniprot id: A0A803JY65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX1 family.
messages: Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
messages: Forms a heterodimer with SLX4.
messages: Nucleus

8364:coq2
gene id: 8364:coq2
uniprot id: F6X1L9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
messages: Mitochondrion inner membrane

8364:fam161b
gene id: 8364:fam161b
uniprot id: A0A6I8PWR5
uniprot id: A0A803J5F7
names: Similarity
messages: Belongs to the FAM161 family.

8364:ltv1
gene id: 8364:ltv1
uniprot id: F7AKE2
names: Similarity
messages: Belongs to the LTV1 family.

8364:acvr2a
gene id: 8364:acvr2a
uniprot id: B5DDW8
uniprot id: F6R871
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

8364:hspb3
gene id: 8364:hspb3
uniprot id: A0A8J0QWZ6
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

8364:atrx
gene id: 8364:atrx
uniprot id: A0A6I8SPZ1
uniprot id: A0A8J0R5A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus
messages: telomere

8364:pcsk2
gene id: 8364:pcsk2
uniprot id: A0JP87
names: Similarity
messages: Belongs to the peptidase S8 family.

8364:gpm6a
gene id: 8364:gpm6a
uniprot id: Q0IHY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

8364:LOC116407589
gene id: 8364:LOC116407589
uniprot id: Q28D68
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:hoxd8
gene id: 8364:hoxd8
uniprot id: B4F728
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100495571
gene id: 8364:LOC100495571
uniprot id: A0A6I8S1C7
uniprot id: A0A8J0SHW4
names: Subcellular Location Annotation
messages: Membrane

8364:c16orf87
gene id: 8364:c16orf87
uniprot id: B0JYZ6
names: Similarity
messages: Belongs to the UPF0547 family.

8364:LOC100495742
gene id: 8364:LOC100495742
uniprot id: A0A6I8RRK9
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:cwc15
gene id: 8364:cwc15
uniprot id: B0JYY8
uniprot id: Q0VFP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC15 family.
messages: Identified in the spliceosome C complex. Component of the minor spliceosome, which splices U12-type introns (By similarity).
messages: Involved in pre-mRNA splicing as component of the spliceosome.
messages: Nucleus

8364:itga1
gene id: 8364:itga1
uniprot id: F7B2H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

8364:LOC100497944
gene id: 8364:LOC100497944
uniprot id: A0A8J1IQ60
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:LOC100493724
gene id: 8364:LOC100493724
uniprot id: A0A8J0QVT1
names: Similarity
messages: Belongs to the JIP scaffold family.

8364:afmid
gene id: 8364:afmid
uniprot id: A0A8J0SWP4
uniprot id: A9JTU4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynurenine formamidase family.
messages: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.
messages: Homodimer.
messages: Nucleus
messages: The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
messages: cytosol

8364:bdkrb2
gene id: 8364:bdkrb2
uniprot id: F7BR72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.
messages: Membrane
messages: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

8364:selenom
gene id: 8364:selenom
uniprot id: A0A8J0QDF7
names: Similarity
messages: Belongs to the selenoprotein M/F family.

8364:chd4
gene id: 8364:chd4
uniprot id: A0A6I8RFD2
uniprot id: A0A8J0SHK7
uniprot id: A0A8J0SPK5
uniprot id: A0A8J0SR40
uniprot id: A3KN93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

8364:stambp
gene id: 8364:stambp
uniprot id: A0A7D9N0C4
uniprot id: B1H101
names: Similarity
messages: Belongs to the peptidase M67C family.

8364:LOC734139
gene id: 8364:LOC734139
uniprot id: A0A8J1J7M5
uniprot id: Q28BQ3
names: Similarity
messages: Belongs to the aldo/keto reductase family.

8364:b3galt5.3
gene id: 8364:b3galt5.3
uniprot id: A0A803JVI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:carmil3
gene id: 8364:carmil3
uniprot id: A0A6I8QVC3
uniprot id: A0A8J0S7C4
uniprot id: A0A8J0SF63
uniprot id: A0A8J1J1M6
uniprot id: B2GU77
uniprot id: F7A183
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CARMIL family.
messages: Cytoplasm

8364:elavl2
gene id: 8364:elavl2
uniprot id: A0A803KBF4
uniprot id: A0A8J0SEU7
uniprot id: A0A8J0SLV5
uniprot id: A0A8J0SPG8
uniprot id: A0A8J0SPH4
uniprot id: A0A8J0SPI2
uniprot id: A0A8J0SPI8
uniprot id: A0A8J0SPJ3
uniprot id: A0A8J0T2S5
uniprot id: A0A8J1JI06
uniprot id: A0A8J1JJ25
uniprot id: F7EBU6
uniprot id: Q28GD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM elav family.
messages: Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Required for the vegetal localization of vg1 mRNA. Probably required for nervous system development (By similarity).
messages: Cytoplasm
messages: Part of a ribonucleoprotein (RNP) complex, at least composed of elavl1/elrA and/or elavl2/elrB, igf2bp3/vg1RBP, ddx6/Xp54, ybx2/frgy2, lsm14b/rap55b and, in a subset of RNP complexes, stau1/staufen. Binds RNA as a homooligomer (By similarity).
messages: cell cortex

8364:ddx27
gene id: 8364:ddx27
uniprot id: A0A8J0SBQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family.
messages: Cytoplasm
messages: Nucleus

8364:tshz3
gene id: 8364:tshz3
uniprot id: A0A803JLG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.
messages: Nucleus

8364:atg5
gene id: 8364:atg5
uniprot id: A0A6I8Q192
uniprot id: A0A8J0SNW9
uniprot id: A0A8J1JI71
uniprot id: A0A8J1JI74
uniprot id: B1WB05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
messages: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
messages: Preautophagosomal structure membrane

8364:glyatl2
gene id: 8364:glyatl2
uniprot id: A0A6I8RQD3
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

8364:taf10
gene id: 8364:taf10
uniprot id: A0A803JJV9
uniprot id: A0A8J0PJE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF10 family.
messages: Nucleus

8364:phtf1
gene id: 8364:phtf1
uniprot id: A0A803JYW9
uniprot id: B1WB00
names: Subcellular Location Annotation
messages: Membrane

8364:tmtc2
gene id: 8364:tmtc2
uniprot id: A0A8J0SRW3
uniprot id: A0A8J1J6A0
uniprot id: A4IIJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

8364:psmb2
gene id: 8364:psmb2
uniprot id: Q5XH87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

8364:tcirg1
gene id: 8364:tcirg1
uniprot id: A0A6I8QDQ1
uniprot id: A0A8J1JSS4
uniprot id: A0A8J1JSU3
uniprot id: A0A8J1JV95
uniprot id: F6S802
uniprot id: Q28DM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

8364:slc37a3
gene id: 8364:slc37a3
uniprot id: F7A0H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

8364:sgcb
gene id: 8364:sgcb
uniprot id: B3DM44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.
messages: cytoskeleton
messages: sarcolemma

8364:LOC100496115
gene id: 8364:LOC100496115
uniprot id: A0A8J0QR95
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:sfmbt1
gene id: 8364:sfmbt1
uniprot id: A0A8J0QFX0
names: Subcellular Location Annotation
messages: Nucleus

8364:adam22
gene id: 8364:adam22
uniprot id: A0A6I8RU22
uniprot id: A0A8J1JRD2
uniprot id: E2ICL8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:grwd1
gene id: 8364:grwd1
uniprot id: F6Z3Y6
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100492511
gene id: 8364:LOC100492511
uniprot id: A0A8J1J8H3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:MGC108429
gene id: 8364:MGC108429
uniprot id: A0A8J0SVQ8
uniprot id: F6V986
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

8364:foxf2
gene id: 8364:foxf2
uniprot id: A4IIG1
names: Subcellular Location Annotation
messages: Nucleus

8364:tmc8
gene id: 8364:tmc8
uniprot id: A0A803JES9
uniprot id: A0A803K3T3
uniprot id: A0A8J1J0G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

8364:fgb
gene id: 8364:fgb
uniprot id: B0JZ09
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

8364:nhej1
gene id: 8364:nhej1
uniprot id: F7AXY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XLF subfamily.
messages: Nucleus

8364:lctl
gene id: 8364:lctl
uniprot id: A0A6I8R1P7
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

8364:rnpc3
gene id: 8364:rnpc3
uniprot id: Q07G30
names: Subcellular Location Annotation
messages: Nucleus

8364:slc6a13
gene id: 8364:slc6a13
uniprot id: Q0VFM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8364:slc39a2
gene id: 8364:slc39a2
uniprot id: F6RAP0
names: Subcellular Location Annotation
messages: Membrane

8364:aff2
gene id: 8364:aff2
uniprot id: F6WY12
names: Similarity
messages: Belongs to the AF4 family.

8364:tlcd5
gene id: 8364:tlcd5
uniprot id: F7D8K5
names: Subcellular Location Annotation
messages: Membrane

8364:hdac10
gene id: 8364:hdac10
uniprot id: A0A8J0QLK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Cytoplasm

8364:pkd1l2
gene id: 8364:pkd1l2
uniprot id: A0A6I8PPD8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:actr2
gene id: 8364:actr2
uniprot id: A0A8J1JLV5
uniprot id: Q5BL41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).
messages: Belongs to the actin family.
messages: Belongs to the actin family. ARP2 subfamily.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of actr2/arp2, actr3/arp3, arpc1b, arpc2, arpc3, arpc4 and arpc5.
messages: Nucleus
messages: cytoskeleton

8364:wscd1
gene id: 8364:wscd1
uniprot id: Q0IIY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WSCD family.
messages: Golgi apparatus membrane
messages: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.

8364:LOC108645664
gene id: 8364:LOC108645664
uniprot id: A0A1B8XT87
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:phactr1
gene id: 8364:phactr1
uniprot id: B5DE18
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

8364:nudt4
gene id: 8364:nudt4
uniprot id: A0A8J1J726
uniprot id: F7EUS5
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

8364:LOC101734865
gene id: 8364:LOC101734865
uniprot id: A0A8J1IP96
uniprot id: A0A8J1IP97
uniprot id: A0A8J1IP98
uniprot id: A0A8J1IRQ3
uniprot id: A0A8J1ISE5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Membrane

8364:tradd
gene id: 8364:tradd
uniprot id: A0A6I8PY50
names: Subcellular Location Annotation
messages: Nucleus
messages: cytoskeleton

8364:fap
gene id: 8364:fap
uniprot id: A9ULG1
names: Subcellular Location Annotation
messages: Cell membrane
messages: invadopodium membrane
messages: lamellipodium membrane

8364:LOC116407755
gene id: 8364:LOC116407755
uniprot id: A0A8J1IVH6
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC100487364
gene id: 8364:LOC100487364
uniprot id: A0A8J0QV97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPACA4/bouncer family.
messages: Cell membrane
messages: Membrane

8364:myo1a
gene id: 8364:myo1a
uniprot id: Q66JE1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:rab3a
gene id: 8364:rab3a
uniprot id: Q28H43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

8364:LOC100488194
gene id: 8364:LOC100488194
uniprot id: A0A8J0QJN2
names: Subcellular Location Annotation
messages: Membrane

8364:timm8b
gene id: 8364:timm8b
uniprot id: Q28GN7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

8364:LOC116412385
gene id: 8364:LOC116412385
uniprot id: A0A8J1K146
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

8364:sap30l
gene id: 8364:sap30l
uniprot id: Q28H91
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SAP30 family.
messages: Functions as transcription repressor, probably via its interaction with histone deacetylase complexes. Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus. Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA. Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import.
messages: Interacts with components of the histone deacetylase complex sin3a, hdac1 and hdac2. Binds histones and nucleosomes.
messages: The zinc-finger domain mediates direct interaction with DNA and phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate). In vitro oxydation causes reversible disulfide bond formation between Cys residues in the zinc-finger domain and reversible loss of zinc ion binding.
messages: nucleolus

8364:atp13a2
gene id: 8364:atp13a2
uniprot id: A0A803JN09
uniprot id: A0A803JSD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

8364:htr1e
gene id: 8364:htr1e
uniprot id: A0A6I8R5Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:rpl7
gene id: 8364:rpl7
uniprot id: A0A803KHR9
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

8364:hadh
gene id: 8364:hadh
uniprot id: Q5XGI2
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

8364:gjc1
gene id: 8364:gjc1
uniprot id: A0A803JZ83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Gamma-type subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8364:atp5f1a
gene id: 8364:atp5f1a
uniprot id: A0A8J1JJC9
uniprot id: Q5BKH9
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

8364:grb7
gene id: 8364:grb7
uniprot id: A0A6I8RBI5
uniprot id: A0A803JYW8
uniprot id: F6RU56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

8364:ap1g2
gene id: 8364:ap1g2
uniprot id: F6XAZ7
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

8364:kif27
gene id: 8364:kif27
uniprot id: A0A6I8R736
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8364:suclg1
gene id: 8364:suclg1
uniprot id: Q5BKK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

8364:ctnnd2
gene id: 8364:ctnnd2
uniprot id: A0A6I8QYB0
uniprot id: A0A8J1JNS2
uniprot id: A0A8J1JNS7
uniprot id: A0A8J1JNT2
uniprot id: A0A8J1JNT4
uniprot id: A0A8J1JNT7
uniprot id: A0A8J1JNT8
uniprot id: A0A8J1JNU1
uniprot id: A0A8J1JR85
uniprot id: A0A8J1JR94
uniprot id: A0A8J1JSJ5
uniprot id: A0A8J1JSK0
names: Similarity
messages: Belongs to the beta-catenin family.

8364:kcnh7
gene id: 8364:kcnh7
uniprot id: A0A6I8QVR8
uniprot id: A0A8J1ITV3
uniprot id: A0A8J1ITW3
uniprot id: A0A8J1IW94
names: Subcellular Location Annotation
messages: Membrane

8364:rmnd5a
gene id: 8364:rmnd5a
uniprot id: Q640V2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase component of the CTLH complex.
messages: Identified in the CTLH complex that contains at least RANBP9, MKLN1, MAEA, RMND5A, GID8 and ARMC8.
messages: nucleoplasm

8364:impg1
gene id: 8364:impg1
uniprot id: A0A803JUS8
names: Subcellular Location Annotation
messages: interphotoreceptor matrix

8364:gltp
gene id: 8364:gltp
uniprot id: F7BWR3
names: Similarity
messages: Belongs to the GLTP family.

8364:tctn1
gene id: 8364:tctn1
uniprot id: A0A8J1J3Y3
uniprot id: Q07G70
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

8364:anp32b
gene id: 8364:anp32b
uniprot id: A0A8J0SND7
uniprot id: F6ZP24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANP32 family.
messages: Multifunctional protein that is involved in the regulation of many processes.
messages: Nucleus

8364:epha4
gene id: 8364:epha4
uniprot id: A0A8J0SWZ8
uniprot id: A0A8J0T0R8
uniprot id: A0A8J0T400
uniprot id: B4F704
uniprot id: F6QKP3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Membrane

8364:fam241b
gene id: 8364:fam241b
uniprot id: A0A803J5N6
uniprot id: A0A8J0SSB9
uniprot id: Q5M8D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

8364:LOC116412372
gene id: 8364:LOC116412372
uniprot id: A0A8J1K120
names: Subcellular Location Annotation
messages: Membrane

8364:LOC116406839
gene id: 8364:LOC116406839
uniprot id: A0A8J1IPZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:leprot
gene id: 8364:leprot
uniprot id: A0A0B4J2K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

8364:atp11b
gene id: 8364:atp11b
uniprot id: A0A6I8QJS2
uniprot id: A0A8J0R3F9
uniprot id: A0A8J0R420
uniprot id: A0A8J1JJE5
uniprot id: A0A8J1JJE6
uniprot id: A0A8J1JJE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

8364:LOC100485192
gene id: 8364:LOC100485192
uniprot id: A0A803J566
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100492100
gene id: 8364:LOC100492100
uniprot id: A0A8J1JGA5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:gpr65
gene id: 8364:gpr65
uniprot id: A0A6I8QWZ1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:baat
gene id: 8364:baat
uniprot id: A4IIX4
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

8364:dnajb6
gene id: 8364:dnajb6
uniprot id: Q6P642
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Also reduces cellular toxicity and caspase-3 activity.
messages: Homooligomer.
messages: Nucleus
messages: perinuclear region

8364:LOC100489129
gene id: 8364:LOC100489129
uniprot id: F6PX16
names: Similarity
messages: Belongs to the intermediate filament family.

8364:il28b.1
gene id: 8364:il28b.1
uniprot id: D2DJP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

8364:dnaja4.2
gene id: 8364:dnaja4.2
uniprot id: Q28EH5
names: Subcellular Location Annotation
messages: Membrane

8364:mief1
gene id: 8364:mief1
uniprot id: Q501R1
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

8364:krtcap2
gene id: 8364:krtcap2
uniprot id: A4IH06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRTCAP2 family.
messages: Membrane

8364:rasgef1b
gene id: 8364:rasgef1b
uniprot id: Q28EC1
names: Function
messages: Guanine nucleotide exchange factor (GEF) with specificity for rap2a and other Ras family proteins (in vitro).

8364:slc2a13
gene id: 8364:slc2a13
uniprot id: A0A6I8RDZ2
uniprot id: A0A8J1JAH2
uniprot id: F6TZZ1
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

8364:ankrd1
gene id: 8364:ankrd1
uniprot id: Q5BKI6
names: Function
names: Subcellular Location Annotation
messages: May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes.
messages: Nucleus

8364:ccdc153
gene id: 8364:ccdc153
uniprot id: A0A8J0R5L1
names: Similarity
messages: Belongs to the UPF0610 family.

8364:LOC101732477
gene id: 8364:LOC101732477
uniprot id: A0A8J1JJI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Photoreceptor outer segment membrane

8364:cd164
gene id: 8364:cd164
uniprot id: A0A5S6MNG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

8364:tigd5
gene id: 8364:tigd5
uniprot id: A0A6I8RZP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tigger transposable element derived protein family.
messages: Nucleus

8364:ipo8
gene id: 8364:ipo8
uniprot id: A0A8J1JBZ6
uniprot id: F6QR70
names: Subcellular Location Annotation
messages: Cytoplasm

8364:LOC100145493
gene id: 8364:LOC100145493
uniprot id: A0A8J0T2D8
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

8364:LOC105945591
gene id: 8364:LOC105945591
uniprot id: A0A8J1IQX8
uniprot id: A0A8J1ITC9
uniprot id: A0A8J1IU49
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:dnhd1
gene id: 8364:dnhd1
uniprot id: A0A8J1J8G9
names: Similarity
messages: Belongs to the dynein heavy chain family.

8364:lama1
gene id: 8364:lama1
uniprot id: A0A8J0QPC2
uniprot id: F7AVS9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

8364:cp
gene id: 8364:cp
uniprot id: A0A6I8Q1B1
names: Similarity
messages: Belongs to the multicopper oxidase family.

8364:nrxn3
gene id: 8364:nrxn3
uniprot id: A0A8J0T5E6
uniprot id: A0A8J1IME2
uniprot id: A0A8J1IME4
uniprot id: A0A8J1IME5
uniprot id: A0A8J1IME7
uniprot id: A0A8J1IME8
uniprot id: A0A8J1IME9
uniprot id: A0A8J1IMF1
uniprot id: A0A8J1IMF2
uniprot id: A0A8J1IMF4
uniprot id: A0A8J1IPM5
uniprot id: A0A8J1IPN0
uniprot id: A0A8J1IQB5
uniprot id: A0A8J1IQC0
uniprot id: A0A8J1IQC5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:serpinb5
gene id: 8364:serpinb5
uniprot id: A0A8J1JRI8
uniprot id: Q5M8J5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family. Ov-serpin subfamily.
messages: May not exhibit serine protease inhibitory activity.
messages: extracellular space

8364:tgfbr2.2
gene id: 8364:tgfbr2.2
uniprot id: A0A6I8T273
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane
messages: Membrane raft

8364:LOC116407779
gene id: 8364:LOC116407779
uniprot id: A0A8J1IVN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:zfhx2
gene id: 8364:zfhx2
uniprot id: A0A6I8QG57
uniprot id: A0A8J0SWH1
names: Subcellular Location Annotation
messages: Nucleus

8364:zranb1
gene id: 8364:zranb1
uniprot id: A0A6I8SFJ4
uniprot id: B1H2Q2
uniprot id: F6YRP5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C64 family.
messages: Cytoplasm
messages: Nucleus
messages: The OTU domain mediates the deubiquitinating activity.
messages: The RanBP2-type zinc fingers, also called NZFs, mediate the interaction with ubiquitin and determine linkage specificity. RanBP2-type zinc fingers 1 and 2 (also named NZF1 and NZF2) specifically recognize and bind 'Lys-29'- and 'Lys-33'-linked ubiquitin. RanBP2-type zinc finger 3 (also named NZF3) binds 'Lys-33'-linked ubiquitin and shows weak binding to 'Lys-6'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin chains but it does not interact with 'Lys-29'-linked chains.
messages: The second ankyrin repeat ANK 2 is termed AnkUBD, it interacts with ubiquitin hydrophobic patch and contributes to linkage specificity.
messages: Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin (By similarity). Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones (By similarity). Positive regulator of the Wnt signaling pathway that deubiquitinates apc protein, a negative regulator of Wnt-mediated transcription (By similarity). Acts as a regulator of autophagy by mediating deubiquitination of pik3c3/vps34, thereby promoting autophagosome maturation (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Required in the stress fiber dynamics and cell migration (By similarity).

8364:adgra2
gene id: 8364:adgra2
uniprot id: A0A6I8QSI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

8364:diaph3
gene id: 8364:diaph3
uniprot id: A0A8J1J522
uniprot id: A0A8J1J528
uniprot id: A0A8J1J532
uniprot id: A0A8J1J7H9
uniprot id: A0A8J1J8H9
names: Similarity
messages: Belongs to the formin homology family. Diaphanous subfamily.

8364:pik3c2b
gene id: 8364:pik3c2b
uniprot id: A0A8J1J4A5
uniprot id: A0A8J1J4B3
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

8364:gpr182
gene id: 8364:gpr182
uniprot id: A0A803J537
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:c1orf174
gene id: 8364:c1orf174
uniprot id: A0JM83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0688 family.
messages: Nucleus

8364:mrpl32
gene id: 8364:mrpl32
uniprot id: F6Y7I1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

8364:creld1
gene id: 8364:creld1
uniprot id: A0A6I8RMG7
names: Caution
names: Similarity
messages: Belongs to the CRELD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:tardbp
gene id: 8364:tardbp
uniprot id: A0A6I8SMZ7
uniprot id: A0A8J0SRW4
uniprot id: G1K3B4
uniprot id: Q28F51
names: Caution
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: It is uncertain whether Met-1 or Met-3 is the initiator.
messages: Mitochondrion
messages: Nucleus
messages: Probably involved in transcriptional repression (By similarity). May play a role in the maintenance of the circadian clock periodicity.
messages: Stress granule
messages: The RRM domains can bind to both DNA and RNA.

8364:cryga.4
gene id: 8364:cryga.4
uniprot id: A0A8J0QSC7
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:LOC101734214
gene id: 8364:LOC101734214
uniprot id: A0A6I8R0N1
uniprot id: A0A8J0R220
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

8364:grpel2
gene id: 8364:grpel2
uniprot id: B5DED9
names: Similarity
messages: Belongs to the GrpE family.

8364:stxbp2
gene id: 8364:stxbp2
uniprot id: Q6DJA6
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

8364:xpc
gene id: 8364:xpc
uniprot id: A0A6I8PUF7
uniprot id: A0A8J0QTM7
uniprot id: A0A8J0QZ58
uniprot id: A0A8J0R3C4
uniprot id: A0A8J0R3Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPC family.
messages: Nucleus

8364:LOC101731906
gene id: 8364:LOC101731906
uniprot id: A0A6I8QNA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

8364:tyr
gene id: 8364:tyr
uniprot id: A4QNF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

8364:adamts7
gene id: 8364:adamts7
uniprot id: A0A6I8R3P0
uniprot id: A0A8J0R1W8
uniprot id: A0A8J1JB75
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:dhps
gene id: 8364:dhps
uniprot id: F6RYK2
uniprot id: Q28HP4
uniprot id: Q6P7K8
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

8364:pdp1
gene id: 8364:pdp1
uniprot id: A0A8J0SR64
uniprot id: Q0VA38
names: Similarity
messages: Belongs to the PP2C family.

8364:prss12
gene id: 8364:prss12
uniprot id: A0A6I8R3C7
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
messages: Secreted

8364:ndufc2
gene id: 8364:ndufc2
uniprot id: A0A1B8Y3G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC2 subunit family.
messages: Mitochondrion inner membrane

8364:s1pr1
gene id: 8364:s1pr1
uniprot id: F6Y7C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:atp2a2
gene id: 8364:atp2a2
uniprot id: A0A6I8Q7N3
uniprot id: A0A8J1ISI4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

8364:ccn1
gene id: 8364:ccn1
uniprot id: A0A7D9NK08
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:cnot3
gene id: 8364:cnot3
uniprot id: A0A8J0SI34
uniprot id: A0A8J0SRP1
uniprot id: A0A8J0SSQ8
uniprot id: A0A8J0SV36
uniprot id: A0A8J0T4I6
uniprot id: B2GUB5
uniprot id: F6WVD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT2/3/5 family.
messages: Cytoplasm
messages: Nucleus

8364:LOC116410505
gene id: 8364:LOC116410505
uniprot id: A0A8J1JJK1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natural cytotoxicity receptor (NCR) family.
messages: Cell membrane
messages: Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6.
messages: Membrane

8364:tpte2
gene id: 8364:tpte2
uniprot id: F7DBU7
names: Similarity
messages: Belongs to the PTEN phosphatase protein family.

8364:cdh20
gene id: 8364:cdh20
uniprot id: A0A8J0SQQ0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane

8364:LOC100496658
gene id: 8364:LOC100496658
uniprot id: F6YW30
names: Function
messages: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

8364:cog3
gene id: 8364:cog3
uniprot id: A0A6I8SWB7
names: Function
names: Similarity
messages: Belongs to the COG3 family.
messages: Involved in ER-Golgi transport.

8364:slc26a7
gene id: 8364:slc26a7
uniprot id: A0A8J0QPN0
uniprot id: A0A8J0SGW7
uniprot id: A0A8J0SRI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

8364:arsj
gene id: 8364:arsj
uniprot id: A0A7D9N0J1
names: Similarity
messages: Belongs to the sulfatase family.

8364:gpc1
gene id: 8364:gpc1
uniprot id: Q0V9W0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.
messages: O-glycosylated with heparan sulfate side chains.
messages: extracellular space

8364:LOC101733973
gene id: 8364:LOC101733973
uniprot id: A0A8J1IZA8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:slc35e1
gene id: 8364:slc35e1
uniprot id: B7ZTJ7
names: Subcellular Location Annotation
messages: Membrane

8364:ap2m1
gene id: 8364:ap2m1
uniprot id: A0A8J1JHW1
uniprot id: A0A8J1JHW2
uniprot id: Q6P856
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit and beta-type subunit), a medium adaptin (mu-type subunit) and a small adaptin (sigma-type subunit).
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositide-containing lipids.
messages: coated pit

8364:pitpnm3
gene id: 8364:pitpnm3
uniprot id: A0A6I8QNC5
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

8364:ggt1
gene id: 8364:ggt1
uniprot id: A0A8J0PDW8
uniprot id: Q6DIS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
messages: Membrane

8364:LOC105947904
gene id: 8364:LOC105947904
uniprot id: A0A8J0SRN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:ddx56
gene id: 8364:ddx56
uniprot id: B1WAT1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family.
messages: Cytoplasm
messages: Nucleus
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

8364:mrps9
gene id: 8364:mrps9
uniprot id: F6YRQ1
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

8364:atp6v0a1
gene id: 8364:atp6v0a1
uniprot id: A0A1B8Y5L8
uniprot id: A0A6I8QLS2
uniprot id: A0A6I8QZ29
uniprot id: A0A8J0SZS0
uniprot id: A0A8J1IW21
uniprot id: A0A8J1IYF6
uniprot id: A0A8J1IZ70
uniprot id: A1A5G6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Melanosome
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Required for assembly and activity of the vacuolar ATPase (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits (By similarity).
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

8364:ttyh2
gene id: 8364:ttyh2
uniprot id: Q6P1U2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Probable large-conductance Ca(2+)-activated chloride channel.

8364:arap3
gene id: 8364:arap3
uniprot id: A0A6I8RI60
uniprot id: A0A6I8SUR6
names: Subcellular Location Annotation
messages: Cytoplasm

8364:LOC100493041
gene id: 8364:LOC100493041
uniprot id: A0A1B8XZW2
uniprot id: Q28D37
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by rag1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:gpr135
gene id: 8364:gpr135
uniprot id: A0A803JSB9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:ube2e2
gene id: 8364:ube2e2
uniprot id: B0BM03
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8364:LOC100492957
gene id: 8364:LOC100492957
uniprot id: A0A8J0T536
uniprot id: A0A8J1K0U0
uniprot id: F6ZPM3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8364:tmem115
gene id: 8364:tmem115
uniprot id: A0A8J0PH19
names: Subcellular Location Annotation
messages: Membrane

8364:LOC105945399
gene id: 8364:LOC105945399
uniprot id: A0A8J0SA16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:slc5a1.1
gene id: 8364:slc5a1.1
uniprot id: A0A803J7A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

8364:spsb3
gene id: 8364:spsb3
uniprot id: B1H148
uniprot id: Q28DT9
names: Domain
names: Function
names: Similarity
messages: Belongs to the SPSB family.
messages: May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
messages: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.

8364:LOC100145110
gene id: 8364:LOC100145110
uniprot id: B0JYS2
names: Subcellular Location Annotation
messages: Membrane

8364:stard3
gene id: 8364:stard3
uniprot id: A0A803KL11
uniprot id: F6SKV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

8364:pygm
gene id: 8364:pygm
uniprot id: Q6NV69
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

8364:dtx4
gene id: 8364:dtx4
uniprot id: A0A6I8SBZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

8364:tecr
gene id: 8364:tecr
uniprot id: Q5BKP0
uniprot id: Q68EQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:LOC116409552
gene id: 8364:LOC116409552
uniprot id: A0A8J1J8A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100485697
gene id: 8364:LOC100485697
uniprot id: A0A6I8SAW5
names: Subcellular Location Annotation
messages: Nucleus

8364:olah
gene id: 8364:olah
uniprot id: Q6NVK7
names: Similarity
messages: Belongs to the thioesterase family.

8364:LOC116406469
gene id: 8364:LOC116406469
uniprot id: A0A1B8XZW2
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:dcp2
gene id: 8364:dcp2
uniprot id: Q28DQ4
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

8364:cpox
gene id: 8364:cpox
uniprot id: F6QTP1
names: Similarity
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Homodimer.

8364:LOC100494190
gene id: 8364:LOC100494190
uniprot id: A0A8J1JP59
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:gfra1
gene id: 8364:gfra1
uniprot id: A4IIP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane

8364:glt8d2
gene id: 8364:glt8d2
uniprot id: F6WXY9
names: Subcellular Location Annotation
messages: Membrane

8364:zfhx3
gene id: 8364:zfhx3
uniprot id: F6Y4J1
names: Subcellular Location Annotation
messages: Nucleus

8364:ddx39b
gene id: 8364:ddx39b
uniprot id: Q6P8E8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:mybl1
gene id: 8364:mybl1
uniprot id: A0A6I8RD90
uniprot id: A0A8J0SGY2
uniprot id: A0A8J1JPR1
uniprot id: A0A8J1JS91
uniprot id: F6UHZ8
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100487354
gene id: 8364:LOC100487354
uniprot id: A0A6I8QIX2
names: Subcellular Location Annotation
messages: Membrane

8364:tesmin
gene id: 8364:tesmin
uniprot id: A0A8J0T2C2
uniprot id: A0A8J0T2R3
uniprot id: A0A8J1JIR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

8364:LOC116409783
gene id: 8364:LOC116409783
uniprot id: A0A8J1JB89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8364:sesn3
gene id: 8364:sesn3
uniprot id: A0A6I8SKA8
uniprot id: F7C5U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

8364:cnpy2
gene id: 8364:cnpy2
uniprot id: Q28FU2
names: Similarity
messages: Belongs to the canopy family.

8364:cfl2
gene id: 8364:cfl2
uniprot id: Q5U4Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family.
messages: Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity).
messages: Nucleus matrix
messages: cytoskeleton

8364:LOC733561
gene id: 8364:LOC733561
uniprot id: F7AX35
names: Similarity
messages: Belongs to the histone H2B family.

8364:uck2
gene id: 8364:uck2
uniprot id: B1H116
names: Function
names: Similarity
names: Subunit
messages: Belongs to the uridine kinase family.
messages: Homotetramer.
messages: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor.

8364:sh3gl3
gene id: 8364:sh3gl3
uniprot id: A0A6I8S6I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

8364:c2orf49
gene id: 8364:c2orf49
uniprot id: F7BDK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ashwin family.
messages: Nucleus

8364:LOC105947118
gene id: 8364:LOC105947118
uniprot id: A0A6I8RQ36
names: Similarity
messages: Belongs to the peptidase C1 family.

8364:ccn1l
gene id: 8364:ccn1l
uniprot id: A0A803KCD0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:LOC101730588
gene id: 8364:LOC101730588
uniprot id: A0A8J0R2N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:marveld2
gene id: 8364:marveld2
uniprot id: Q0IHQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: May play a role in the formation of the epithelial barrier.
messages: tight junction

8364:agrp
gene id: 8364:agrp
uniprot id: A0A8J1JFG4
uniprot id: J3A6E8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:fgf9
gene id: 8364:fgf9
uniprot id: F6ZB49
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

8364:cdpf1
gene id: 8364:cdpf1
uniprot id: A0A1B8Y385
uniprot id: A0A803JU85
names: Similarity
messages: Belongs to the CDPF1 family.

8364:LOC101734811
gene id: 8364:LOC101734811
uniprot id: A0A8J0SCX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:krt12.6
gene id: 8364:krt12.6
uniprot id: A0A1B8Y9I8
uniprot id: A0A7D9NLG7
names: Similarity
messages: Belongs to the intermediate filament family.

8364:ltbr
gene id: 8364:ltbr
uniprot id: A0A803J521
uniprot id: A0A803JDB6
uniprot id: A0A8J1JVD2
uniprot id: A0A8J1JVD4
uniprot id: A0A8J1JXT3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC101730723
gene id: 8364:LOC101730723
uniprot id: F6QJR9
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC101731022
gene id: 8364:LOC101731022
uniprot id: A0A8J1J4M7
uniprot id: A0A8J1J4N1
uniprot id: A0A8J1J827
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:ddb2
gene id: 8364:ddb2
uniprot id: Q66JG1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Chromosome
messages: Component of the UV-DDB complex which includes ddb1 and ddb2 (By similarity). Component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex that includes cul4a, or cul4b, ddb1, ddb2 and rbx1. A large number of other DCX complexes may also exist in which an alternate substrate targeting subunit replaces ddb2. These targeting subunits are generally known as DCAF (ddb1- and cul4-associated factor) or CDW (cul4-ddb1-associated WD40-repeat) proteins (By similarity).
messages: Interblade loops of the WD repeat region mediate most of the interaction with DNA. A hairpin between blades 5 and 6 inserts into DNA minor groove and mediates recognition of lesions and separation of the damaged and undamaged strands (By similarity).
messages: Nucleus
messages: Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively. Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair.
messages: The DWD box is required for interaction with ddb1.

8364:tor1aip2
gene id: 8364:tor1aip2
uniprot id: A0A803JEB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOR1AIP family.
messages: Membrane

8364:polr2l.2
gene id: 8364:polr2l.2
uniprot id: Q1ECU1
names: Similarity
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.

8364:nr4a2
gene id: 8364:nr4a2
uniprot id: A0A8J0SUS7
uniprot id: A4IIG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Nucleus
messages: Transcriptional regulator which may play a role in the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons.

8364:mtmr11
gene id: 8364:mtmr11
uniprot id: A0A8J0SW69
uniprot id: F7BG51
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

8364:mab21l2
gene id: 8364:mab21l2
uniprot id: A4IIW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mab-21 family.
messages: Cytoplasm
messages: Nucleus
messages: Required for several aspects of embryonic development including normal development of the eye.

8364:lrp10
gene id: 8364:lrp10
uniprot id: A0A8J0QXX3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:fntb
gene id: 8364:fntb
uniprot id: Q28J66
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
messages: Heterodimer of an alpha and a beta subunit.

8364:LOC100496615
gene id: 8364:LOC100496615
uniprot id: A0A8J0QJM0
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

8364:sumo2
gene id: 8364:sumo2
uniprot id: Q28H04
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Cleavage of precursor form by a sentrin-specific protease is necessary for function.
messages: Interacts with sae2 and ube2i. Covalently attached to a number of proteins, including top2 (By similarity).
messages: Nucleus
messages: Polymeric chains can be formed through Lys-11 cross-linking.
messages: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i, and can be promoted by an E3 ligase such as pias1-4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric sumo2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity).

8364:garem2
gene id: 8364:garem2
uniprot id: A0A8J0QZW1
names: Similarity
messages: Belongs to the GAREM family.

8364:LOC105945140
gene id: 8364:LOC105945140
uniprot id: A0A6I8SB13
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC108644699
gene id: 8364:LOC108644699
uniprot id: A0A8J1JNQ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:c5orf30
gene id: 8364:c5orf30
uniprot id: A4IGV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UNC119-binding protein family.
messages: Cytoplasm
messages: Interacts with unc119 family proteins; interaction preferentially takes place when unc119 proteins are unliganded with myristoylated proteins.
messages: May play a role in immune regulation through regulation of the macrophage function (By similarity). May also play a role in trafficking of proteins via its interaction with unc119 family cargo adapters (By similarity). May play a role in ciliary membrane localization (By similarity).
messages: cilium

8364:ccser1
gene id: 8364:ccser1
uniprot id: A0A803JCS6
uniprot id: A0A803JD43
names: Similarity
messages: Belongs to the CCSER family.

8364:LOC105945571
gene id: 8364:LOC105945571
uniprot id: A0A8J0SCV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:alox15b
gene id: 8364:alox15b
uniprot id: F6Y069
names: Caution
names: Cofactor
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:tff3.3
gene id: 8364:tff3.3
uniprot id: A0A8J0QU96
names: Subcellular Location Annotation
messages: Secreted

8364:nt5dc3
gene id: 8364:nt5dc3
uniprot id: A0A6I8R7I2
uniprot id: A0A8J0SEI2
uniprot id: A4IHT9
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

8364:gdi2
gene id: 8364:gdi2
uniprot id: Q6DK67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

8364:trhr3
gene id: 8364:trhr3
uniprot id: A0A6I8SDQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

8364:cbs
gene id: 8364:cbs
uniprot id: A0A8J1J426
uniprot id: Q640V0
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

8364:vamp2
gene id: 8364:vamp2
uniprot id: Q6P835
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

8364:trnau1apl1
gene id: 8364:trnau1apl1
uniprot id: A0A8J1JT11
uniprot id: Q0VFK2
names: Similarity
messages: Belongs to the RRM TRSPAP family.

8364:LOC116408937
gene id: 8364:LOC116408937
uniprot id: A0A803KEJ3
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

8364:cul3
gene id: 8364:cul3
uniprot id: A4IHP4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cullin family.
messages: Component of multiple BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes formed of cul3, rbx1 and a variable BTB domain-containing protein acting as both, adapter to cullin and substrate recognition subunit (By similarity). Interacts with btbd6 (By similarity).
messages: Neddylated. Attachment of NEDD8 is required for the E3 ubiquitin-protein ligase activity of the SCF-like complex.
messages: Nucleus
messages: Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit (By similarity). Involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division (By similarity). May play a role in the regulation of mittotic entry via ubiquitination of aurka (By similarity).

8364:chmp2b
gene id: 8364:chmp2b
uniprot id: Q6NVL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Late endosome membrane
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity).
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome (By similarity).
messages: cytosol

8364:cryga.6
gene id: 8364:cryga.6
uniprot id: A0A6I8RZY9
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:fut1
gene id: 8364:fut1
uniprot id: Q6EV72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 11 family.
messages: Golgi stack membrane
messages: Membrane

8364:sec63
gene id: 8364:sec63
uniprot id: F7CZX0
names: Subcellular Location Annotation
messages: Membrane

8364:ap4b1
gene id: 8364:ap4b1
uniprot id: F6XFZ2
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

8364:trim72
gene id: 8364:trim72
uniprot id: Q640S6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasmic vesicle membrane
messages: Disulfide bond formation at Cys-244 occurs in case of membrane damage that cause the entry of the oxidized milieu of the extracellular space, resulting in homooligomerization.
messages: Homooligomer; disulfide-linked.
messages: Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process (By similarity).
messages: sarcolemma

8364:nap1l4
gene id: 8364:nap1l4
uniprot id: A0A803J6S5
uniprot id: Q0IHT8
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

8364:astl2d.4
gene id: 8364:astl2d.4
uniprot id: A0A8J0R056
uniprot id: A0A8J0R291
uniprot id: A0A8J0R2L4
uniprot id: A0A8J0R309
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:homer3
gene id: 8364:homer3
uniprot id: A8WGV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

8364:clec16a
gene id: 8364:clec16a
uniprot id: A0A8J0QSN7
uniprot id: A0A8J0R368
uniprot id: A0A8J0R505
uniprot id: A0A8J0R6R9
names: Similarity
messages: Belongs to the CLEC16A/gop-1 family.

8364:adamts15
gene id: 8364:adamts15
uniprot id: A0A6I8T030
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:LOC100498553
gene id: 8364:LOC100498553
uniprot id: A0A1B8Y0L0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:LOC116406799
gene id: 8364:LOC116406799
uniprot id: A0A8J1IPQ8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:bsx
gene id: 8364:bsx
uniprot id: A4IIF9
names: Subcellular Location Annotation
messages: Nucleus

8364:MGC75582
gene id: 8364:MGC75582
uniprot id: P20399
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Actins are highly conserved proteins that are involved in various types of cell motility.
messages: Belongs to the actin family.
messages: Oxidation of Met-46 and Met-49 by MICALs (mical1, mical2 or mical3) to form methionine sulfoxide promotes actin filament depolymerization. Mical1 and mical2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by msrb1 and msrb2, which promote actin repolymerization (By similarity).
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.
messages: Shows a different expression pattern to Xenopus laevis act2. Expressed in stage 24 and 42 embryos as well as in adult heart, but not adult skeletal muscle.
messages: The cardiac versus skeletal expression patterns of actins are probably sequence-dependent. For example, cardiac actins contain a Glu at position 3 of the mature peptide, whereas skeletal actins contain an Asp at this position.
messages: Xenopus contains at least three sarcomeric alpha actin genes that are preferentially expressed in either heart or skeletal muscle.
messages: cytoskeleton

8364:bok
gene id: 8364:bok
uniprot id: A0A6I8PV21
names: Similarity
messages: Belongs to the Bcl-2 family.

8364:uroc1
gene id: 8364:uroc1
uniprot id: Q5BJ54
names: Similarity
messages: Belongs to the urocanase family.

8364:ppp3cb
gene id: 8364:ppp3cb
uniprot id: A0A6I8Q966
uniprot id: A0A8J0SHC4
uniprot id: A2VCU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.
messages: Cytoplasm

8364:tff3.2
gene id: 8364:tff3.2
uniprot id: A0A6I8Q463
names: Subcellular Location Annotation
messages: Secreted

8364:bpgm
gene id: 8364:bpgm
uniprot id: Q28I68
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

8364:LOC101732266
gene id: 8364:LOC101732266
uniprot id: A0A8J1IV66
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:snx10
gene id: 8364:snx10
uniprot id: A0A6I8PW12
uniprot id: Q5XGD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

8364:trappc11
gene id: 8364:trappc11
uniprot id: F7BMF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPPC11 family.
messages: Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.
messages: cis-Golgi network

8364:LOC100485879
gene id: 8364:LOC100485879
uniprot id: A0A8J0QJ06
names: Subcellular Location Annotation
messages: Membrane

8364:baf-l
gene id: 8364:baf-l
uniprot id: A0A6I8PJQ0
uniprot id: A0A8J0SKL3
uniprot id: A0A8J0SN95
uniprot id: A9UL77
names: Subcellular Location Annotation
messages: Nucleus

8364:tent5b
gene id: 8364:tent5b
uniprot id: F7E7M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TENT family.
messages: Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group in an ATP hydrolysis-dependent manner and participates in cytoplasmic polyadenylation (PubMed:34048638). May be involved in maintaining the translation efficiency of at least some genes through preventing degradation of their mRNAs (By similarity).
messages: Cytoplasm
messages: Nucleus

8364:ugt1a6
gene id: 8364:ugt1a6
uniprot id: A9ULE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

8364:irf7
gene id: 8364:irf7
uniprot id: A0A6I8SJ88
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC116410894
gene id: 8364:LOC116410894
uniprot id: A0A8J1JKB1
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:slc25a22
gene id: 8364:slc25a22
uniprot id: A0A803K9G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8364:LOC100145277
gene id: 8364:LOC100145277
uniprot id: A0A8J0QBN8
uniprot id: A0A8J1JS06
uniprot id: A0A8J1JUF7
names: Similarity
messages: Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.

8364:emc4
gene id: 8364:emc4
uniprot id: Q6PBF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC4 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.

8364:slc25a18
gene id: 8364:slc25a18
uniprot id: A0A8J1J8R2
uniprot id: F7B180
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8364:micos10
gene id: 8364:micos10
uniprot id: A9JSD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

8364:krt15.2
gene id: 8364:krt15.2
uniprot id: F7AZ32
names: Similarity
messages: Belongs to the intermediate filament family.

8364:jrk
gene id: 8364:jrk
uniprot id: A0A8J0R7Z8
names: Subcellular Location Annotation
messages: Nucleus

8364:stx16
gene id: 8364:stx16
uniprot id: A0A803JRM7
uniprot id: A0A803K471
uniprot id: A0A803KFA1
uniprot id: A0A8J1IXV5
names: Similarity
messages: Belongs to the syntaxin family.

8364:LOC100485726
gene id: 8364:LOC100485726
uniprot id: A0A6I8PTS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:smco4
gene id: 8364:smco4
uniprot id: B2RZE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMCO4 family.
messages: Membrane

8364:aqp1
gene id: 8364:aqp1
uniprot id: Q6DJ01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

8364:bco2
gene id: 8364:bco2
uniprot id: F6VQ24
uniprot id: Q6DIN7
names: Cofactor
names: Similarity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.

8364:ewsr1
gene id: 8364:ewsr1
uniprot id: Q6DJQ4
uniprot id: Q6P3N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

8364:shfl
gene id: 8364:shfl
uniprot id: A0JP89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SHFL family.
messages: Cytoplasm
messages: Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses and cellular genes. Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site. May exhibit antiviral activity.
messages: Nucleus
messages: P-body

8364:cox14
gene id: 8364:cox14
uniprot id: A0A6I8SAW3
names: Subcellular Location Annotation
messages: Membrane

8364:nup85
gene id: 8364:nup85
uniprot id: Q6DK84
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance (By similarity). Involved in nephrogenesis (PubMed:30179222).
messages: Component of the nuclear pore complex (NPC).
messages: Morpholino knockdown of nup85 results in abnormal pronephric development characterized by underdeveloped to completely absent pronephros.
messages: Nucleus membrane
messages: nuclear pore complex

8364:ywhab
gene id: 8364:ywhab
uniprot id: Q5XGC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity).
messages: Belongs to the 14-3-3 family.
messages: Cytoplasm
messages: Homodimer, and heterodimer with other family members.

8364:LOC116407828
gene id: 8364:LOC116407828
uniprot id: A0A8J1IVW0
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:c18orf32
gene id: 8364:c18orf32
uniprot id: Q28I13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0729 family.
messages: Endoplasmic reticulum
messages: Lipid droplet

8364:zfyve27
gene id: 8364:zfyve27
uniprot id: A0A6I8QDE7
uniprot id: A0A8J0SSJ8
uniprot id: A0A8J0SV28
uniprot id: A0A8J0T232
uniprot id: A0A8J0T452
uniprot id: A0A8J0T4H7
uniprot id: A0A8J0T591
uniprot id: B0JZ44
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: growth cone membrane

8364:hrh4.f6
gene id: 8364:hrh4.f6
uniprot id: A0A8J0SUQ0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:LOC101734017
gene id: 8364:LOC101734017
uniprot id: A0A8J1J8Q9
names: Subcellular Location Annotation
messages: Membrane

8364:osbpl8
gene id: 8364:osbpl8
uniprot id: A0A6I8Q938
uniprot id: A0A6I8SL12
uniprot id: A0A8J0S912
uniprot id: A0A8J0S914
uniprot id: A0A8J0SET9
uniprot id: A0A8J0SEU3
uniprot id: A0A8J0SGJ8
uniprot id: A0A8J1J903
uniprot id: B1H2N0
names: Similarity
messages: Belongs to the OSBP family.

8364:bicdl2
gene id: 8364:bicdl2
uniprot id: Q6DIX6
names: Similarity
messages: Belongs to the BICDR family.

8364:t2r42
gene id: 8364:t2r42
uniprot id: Q2AB45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:LOC116409646
gene id: 8364:LOC116409646
uniprot id: A0A8J1J8P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:fgf19
gene id: 8364:fgf19
uniprot id: B7U4G3
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

8364:sntb2
gene id: 8364:sntb2
uniprot id: B1H3F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

8364:nrp1
gene id: 8364:nrp1
uniprot id: A4III3
names: Caution
names: Similarity
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:otud7a
gene id: 8364:otud7a
uniprot id: A0A8J0R357
uniprot id: F6XXD7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:azin1
gene id: 8364:azin1
uniprot id: A0A8J1JMS2
uniprot id: Q66KD4
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

8364:aqp9
gene id: 8364:aqp9
uniprot id: F6QEC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

8364:dpagt1
gene id: 8364:dpagt1
uniprot id: F6ZLM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:lhx5
gene id: 8364:lhx5
uniprot id: Q28F23
names: Subcellular Location Annotation
messages: Nucleus

8364:ccno
gene id: 8364:ccno
uniprot id: Q6NVR2
names: Similarity
messages: Belongs to the cyclin family.

8364:epb42
gene id: 8364:epb42
uniprot id: A0A8J0QR42
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.

8364:gja1
gene id: 8364:gja1
uniprot id: F6RLQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8364:nadk2
gene id: 8364:nadk2
uniprot id: A0A8J0SHH1
uniprot id: A0A8J0SSC6
uniprot id: Q08CZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD kinase family.
messages: Homodimer.
messages: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor (By similarity).
messages: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.
messages: Mitochondrion

8364:hdgfl2
gene id: 8364:hdgfl2
uniprot id: A0A8J1J5A7
uniprot id: Q6P4K1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HDGF family.
messages: Cytoplasm
messages: May act as a regulator of myogenesis (By similarity). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (By similarity).
messages: Nucleus

8364:zfr
gene id: 8364:zfr
uniprot id: Q5U231
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in postimplantation and gastrulation stages of development. Binds to DNA and RNA (By similarity).
messages: Nucleus

8364:clrn2
gene id: 8364:clrn2
uniprot id: A0A6I8PS27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

8364:pln
gene id: 8364:pln
uniprot id: A0A803K1S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholamban family.
messages: Endoplasmic reticulum membrane
messages: Homopentamer.
messages: Membrane
messages: Mitochondrion membrane
messages: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
messages: Sarcoplasmic reticulum membrane

8364:gls
gene id: 8364:gls
uniprot id: A0A6I8QNV7
uniprot id: A0A6I8RCG3
uniprot id: A0A8J1IVL9
uniprot id: F7AGX9
names: Similarity
messages: Belongs to the glutaminase family.

8364:spcs2
gene id: 8364:spcs2
uniprot id: Q5M8Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPCS2 family.
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity).
messages: Component of the signal peptidase complex paralog A (SPC-A) composed of a catalytic subunit sec11a and three accessory subunits spcs1, spcs2 and spcs3. Component of the signal peptidase complex paralog C (SPC-C) composed of a catalytic subunit sec11c and three accessory subunits spcs1, spcs2 and spcs3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids.
messages: Endoplasmic reticulum membrane

8364:fam149a
gene id: 8364:fam149a
uniprot id: A0A6I8RHD4
uniprot id: A0A8J0QLG9
uniprot id: A0A8J0QXW3
names: Similarity
messages: Belongs to the FAM149 family.

8364:abhd17b
gene id: 8364:abhd17b
uniprot id: Q6DEY3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. ABHD17 family.
messages: Cell membrane
messages: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins.
messages: Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization.
messages: Postsynaptic density membrane
messages: Recycling endosome membrane
messages: dendritic spine

8364:pex2
gene id: 8364:pex2
uniprot id: Q28DK5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of the PEX2-PEX10-PEX12 retrotranslocation channel.
messages: Membrane
messages: Peroxisome membrane

8364:xkr4
gene id: 8364:xkr4
uniprot id: Q4VV72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

8364:rplp0
gene id: 8364:rplp0
uniprot id: A0A8J0S8R1
uniprot id: Q6P8D0
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

8364:parp16
gene id: 8364:parp16
uniprot id: A0A8J1JB60
uniprot id: F6U1A6
names: Similarity
messages: Belongs to the ARTD/PARP family.

8364:pou1f1
gene id: 8364:pou1f1
uniprot id: A0A8J1J602
uniprot id: A0A8J1J721
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

8364:LOC116406574
gene id: 8364:LOC116406574
uniprot id: A0A803JDR9
uniprot id: A0A803JLU4
uniprot id: A0A803JRI8
names: Similarity
messages: Belongs to the DNase I family.

8364:LOC100489443
gene id: 8364:LOC100489443
uniprot id: A0A6I8PXF6
uniprot id: A0A8J1IYZ2
uniprot id: A0A8J1IZ09
uniprot id: A0A8J1IZ21
uniprot id: A0A8J1J1E4
uniprot id: A0A8J1J295
names: Subcellular Location Annotation
messages: Cytoplasm

8364:gja7
gene id: 8364:gja7
uniprot id: A0A1B8Y255
uniprot id: Q6NZH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Belongs to the connexin family. Gamma-type subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8364:LOC116412139
gene id: 8364:LOC116412139
uniprot id: A0A8J1JYM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100492691
gene id: 8364:LOC100492691
uniprot id: A0A8J1JWH8
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

8364:or11h4
gene id: 8364:or11h4
uniprot id: A0A8J0QSS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC116411012
gene id: 8364:LOC116411012
uniprot id: A0A8J1JL75
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane