8355:tmed2.L
gene id: 8355:tmed2.L
uniprot id: A0A974I518
uniprot id: Q7ZXW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

8355:fgf1.S
gene id: 8355:fgf1.S
uniprot id: A0A1L8GVD8
uniprot id: A0A974DBB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: Nucleus
messages: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.
messages: Secreted
messages: cell cortex
messages: cytosol

8355:cebpa.L
gene id: 8355:cebpa.L
uniprot id: A0A974D2V3
uniprot id: Q91346
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

8355:LOC108704406
gene id: 8355:LOC108704406
uniprot id: A0A8J0TWQ9
uniprot id: A0A8J0U4I4
uniprot id: A0A8J0U583
uniprot id: A0A8J0U7B5
uniprot id: A0A8J1KNJ5
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

8355:LOC108697017
gene id: 8355:LOC108697017
uniprot id: A0A1L8FME5
uniprot id: A0A974CGC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:LOC121398041
gene id: 8355:LOC121398041
uniprot id: A0A8J1LSD4
uniprot id: A0A8J1LSF6
uniprot id: A0A8J1LT36
uniprot id: A0A8J1LTU6
names: Similarity
messages: Belongs to the mesothelin family.

8355:LOC121394801
gene id: 8355:LOC121394801
uniprot id: A0A8J1L1F2
names: Subcellular Location Annotation
messages: Cytoplasm

8355:lamp1.S
gene id: 8355:lamp1.S
uniprot id: Q6AXA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lysosome membrane
messages: Membrane

8355:prmt2.L
gene id: 8355:prmt2.L
uniprot id: D9IVE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as histones. Involved in growth regulation (By similarity). Involved in embryonic dorsal development.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
messages: Cytoplasm
messages: Interacts with ctnnb1.
messages: Nucleus

8355:LOC108709028
gene id: 8355:LOC108709028
uniprot id: A0A8J1MFL1
names: Subcellular Location Annotation
messages: Membrane

8355:ubr2.L
gene id: 8355:ubr2.L
uniprot id: A0A8J1KM97
uniprot id: A0A8J1KMC2
uniprot id: A0A8J1KP07
uniprot id: A0A8J1KQF4
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

8355:ccng2.S
gene id: 8355:ccng2.S
uniprot id: A0A974DSW4
uniprot id: Q6NRC3
names: Similarity
messages: Belongs to the cyclin family.

8355:LOC108712738
gene id: 8355:LOC108712738
uniprot id: A0A1L8GRZ3
uniprot id: A0A974D6R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:ccno.L
gene id: 8355:ccno.L
uniprot id: A0A974E2P9
uniprot id: Q32NJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family.
messages: Cytoplasm
messages: Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of mcidas to promote mother centriole amplification and maturation in preparation for apical docking.

8355:ddx31.L
gene id: 8355:ddx31.L
uniprot id: A0A8J1LES2
uniprot id: A0A8J1LES7
uniprot id: A0A8J1LF50
uniprot id: A0A8J1LH74
uniprot id: Q5XG32
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

8355:ppp1r13b.L
gene id: 8355:ppp1r13b.L
uniprot id: A0A8J1LET9
uniprot id: A0A8J1LEU4
uniprot id: A0A8J1LEV2
uniprot id: A0A8J1LEV7
uniprot id: A0A8J1LF82
uniprot id: A0A8J1LGA7
uniprot id: A0A8J1LGB1
uniprot id: A0A8J1LHA7
uniprot id: Q5HZP4
names: Subcellular Location Annotation
messages: Nucleus

8355:pprc1.L
gene id: 8355:pprc1.L
uniprot id: A0A1L8FJC5
uniprot id: A0A974CEN1
names: Subcellular Location Annotation
messages: Nucleus

8355:rarres1.L
gene id: 8355:rarres1.L
uniprot id: A0A8J0V9C6
uniprot id: Q6PB09
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

8355:cacfd1.S
gene id: 8355:cacfd1.S
uniprot id: A0A1L8F0V5
uniprot id: A0A974C256
uniprot id: Q6PA29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel flower family.
messages: Membrane

8355:cog8.L
gene id: 8355:cog8.L
uniprot id: A0A1L8GKV1
uniprot id: A0A974D4I1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG8 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane

8355:XB5947741.L
gene id: 8355:XB5947741.L
uniprot id: Q0IHA3
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108695355
gene id: 8355:LOC108695355
uniprot id: A0A1L8FTD2
uniprot id: A0A8J0T4X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus

8355:tmem170b.L
gene id: 8355:tmem170b.L
uniprot id: A0A8J0VJP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

8355:artn.L
gene id: 8355:artn.L
uniprot id: A0A1L8GM64
uniprot id: A0A974HPC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

8355:LOC121402047
gene id: 8355:LOC121402047
uniprot id: A0A8J1MPN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:aldh5a1.S
gene id: 8355:aldh5a1.S
uniprot id: A0A8J0VM74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
messages: Homotetramer.
messages: Mitochondrion

8355:LOC108697989
gene id: 8355:LOC108697989
uniprot id: A0A1L8FGZ7
uniprot id: A0A8J1LAV9
uniprot id: A0A974CDD3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homomer. Forms heteromers with ACKR4.
messages: Membrane

8355:snrpf.L
gene id: 8355:snrpf.L
uniprot id: A0A974HSR2
uniprot id: P62321
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, snrpb, snrpd1, snrpd2, snrpd3, snrpe, snrpf and snrpg that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins snrpb, snrpd1, snrpd2, snrpd3, snrpe, snrpf and snrpg, and at least three U1 snRNP-specific proteins snrnp70/u1-70k, snrpa/u1-a and snrpc/u1-c. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least prpf3, prpf4, prpf6, prpf8, prpf31, snrnp200, txnl4a, snrnp40, snrpb, snrpd1, snrpd2, snrpd3, snrpe, snrpf, snrpg, ddx23, cd2bp2, ppih, snu13, eftud2, sart1 and usp39, plus lsm2, lsm3, lsm4, lsm5, lsm6, lsm7 and lsm8. Component of the U7 snRNP complex, or U7 Sm protein core complex, that is composed of the U7 snRNA and at least lsm10, lsm11, snrpb, snrpd3, snrpe, snrpf and snrpg; the complex does not contain snrpd1 and snrpd2. Component of the minor spliceosome, which splices U12-type introns. Part of the SMN-Sm complex that contains smn1, gemin2/sip1, ddx20/gemin3, gemin4, gemin5, gemin6, gemin7, gemin8, strap/unrip and the Sm proteins snrpb, snrpd1, snrpd2, snrpd3, snrpe, snrpf and snrpg; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of clns1a/pICln, snrpd1, snrpd2, snrpe, snrpf and snrpg; ring-like structure where clns1a/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

8355:man2a2.L
gene id: 8355:man2a2.L
uniprot id: A0A8J0UNI0
uniprot id: A0A974DFI3
uniprot id: Q6GQ11
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

8355:a1cf.L
gene id: 8355:a1cf.L
uniprot id: A0A1L8FIP5
uniprot id: A0A8J1L4E3
uniprot id: A0A8J1L747
uniprot id: A0A974CEH2
uniprot id: Q6DKE8
names: Subcellular Location Annotation
messages: Cytoplasm

8355:tns4.S
gene id: 8355:tns4.S
uniprot id: A0A1L8EKP0
uniprot id: A0A974H0F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

8355:xpo1.L
gene id: 8355:xpo1.L
uniprot id: A0A1L8G775
uniprot id: A0A974HJ45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

8355:nifk.S
gene id: 8355:nifk.S
uniprot id: A0A974BUR0
uniprot id: Q7SYS2
names: Subcellular Location Annotation
messages: nucleolus

8355:plppr5.S
gene id: 8355:plppr5.S
uniprot id: A0A1L8GG66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

8355:LOC121395427
gene id: 8355:LOC121395427
uniprot id: A0A8J1L8H1
names: Similarity
messages: Belongs to the HARBI1 family.

8355:LOC108699573
gene id: 8355:LOC108699573
uniprot id: A0A1L8FBQ6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

8355:LOC108701189
gene id: 8355:LOC108701189
uniprot id: A0A8J0TVD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

8355:LOC108710175
gene id: 8355:LOC108710175
uniprot id: A0A8J1MKY8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:LOC108702568
gene id: 8355:LOC108702568
uniprot id: A0A1L8EL91
uniprot id: A0A8J0U1Z0
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Membrane
messages: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.

8355:rin2.S
gene id: 8355:rin2.S
uniprot id: A0A1L8G1L7
uniprot id: A0A8J0VKC3
uniprot id: A0A8J1KSJ8
uniprot id: A0A8J1KSJ9
uniprot id: A0A974CQE6
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

8355:sass6.L
gene id: 8355:sass6.L
uniprot id: A0A8J0UA22
uniprot id: A0A8J0UAA2
uniprot id: A0A974E0T2
uniprot id: Q6NRG6
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (By similarity).
messages: Nine homodimers form a cartwheel structure with an internal diameter of 23 nM and radial spokes connecting to the microtubule triplets.
messages: The 35 nM long coiled-coil domain mediates homodimerization while the globular N-terminus links the dimers at an angle of 40 degrees to form the inner ring.
messages: centrosome

8355:gjb2.S
gene id: 8355:gjb2.S
uniprot id: A0A1L8HAU1
uniprot id: A0A974DLG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8355:cpd.S
gene id: 8355:cpd.S
uniprot id: A0A8J1MCI3
names: Similarity
messages: Belongs to the peptidase M14 family.

8355:uts2.S
gene id: 8355:uts2.S
uniprot id: J7M452
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

8355:crygdl.30.L
gene id: 8355:crygdl.30.L
uniprot id: Q66KU7
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:MGC89178.L
gene id: 8355:MGC89178.L
uniprot id: Q6DJF5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:lrtomt.S
gene id: 8355:lrtomt.S
uniprot id: Q5M7E2
names: Subcellular Location Annotation
messages: Cytoplasm

8355:mapk4.L
gene id: 8355:mapk4.L
uniprot id: A0A1L8I2U2
uniprot id: A0A8J1L981
uniprot id: A0A974I5M3
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

8355:p4ha1.L
gene id: 8355:p4ha1.L
uniprot id: A0A1L8FJT6
uniprot id: A0A8J0T149
uniprot id: A0A8J0T7U1
uniprot id: A0A8J0TB00
uniprot id: A0A8J1L5B8
uniprot id: A0A974CFN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

8355:wdr77.S
gene id: 8355:wdr77.S
uniprot id: Q6NUD0
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Detected in egg (at protein level).
messages: Heterotetramer; dimer of heterodimer with prmt5. Interacts with histone h2a and h4 and with nucleoplasmin.
messages: Non-catalytic component of the 20S prmt5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. Required for normal prmt5 methyltransferase activity.
messages: Nucleus

8355:entpd8.S
gene id: 8355:entpd8.S
uniprot id: A0A1L8F0R8
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

8355:LOC108713680
gene id: 8355:LOC108713680
uniprot id: A0A8J1N0H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:LOC121393874
gene id: 8355:LOC121393874
uniprot id: A0A8J1KTL7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:ccdc85c.L
gene id: 8355:ccdc85c.L
uniprot id: A0A8J0U5N2
uniprot id: A0A8J1LHG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

8355:psme3.S
gene id: 8355:psme3.S
uniprot id: A0A8J0TQP6
uniprot id: A0A8J1M0A1
uniprot id: A0A8J1M177
uniprot id: A0A974BT30
uniprot id: Q640F3
names: Similarity
messages: Belongs to the PA28 family.

8355:wls.S
gene id: 8355:wls.S
uniprot id: A0A974D049
uniprot id: Q66IZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the wntless family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Required for a subset of Wnt-dependent developmental processes, in particular, eye and pronephros development. Regulates the secretion of wnt4, which is required for eye development (By similarity).

8355:kdm1a.S
gene id: 8355:kdm1a.S
uniprot id: A0A8J0UJD6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavin monoamine oxidase family.
messages: Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity.
messages: Nucleus
messages: The SWIRM domain may act as an anchor site for a histone tail.

8355:atp5mc1.S
gene id: 8355:atp5mc1.S
uniprot id: A0A8J0UA80
uniprot id: A0A8J0UGY1
uniprot id: A0A8J0UI84
uniprot id: Q6GNG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

8355:usp20.L
gene id: 8355:usp20.L
uniprot id: A0A8J0U5D7
uniprot id: A0A8J0U7H9
uniprot id: B1WBD7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme involved in beta-2 adrenergic receptor (adrb2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (adrb2). Plays a central role in adrb2 recycling and resensitization after prolonged agonist stimulation by constitutively binding adrb2, mediating deubiquitination of adrb2 and inhibiting lysosomal trafficking of adrb2. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
messages: The UBP-type zinc finger binds 3 zinc ions. However, it does not bind ubiquitin, probably because the conserved Arg in position 55 is replaced by a Glu residue (By similarity).
messages: centrosome
messages: perinuclear region

8355:scap.L
gene id: 8355:scap.L
uniprot id: A0A1L8FUT3
uniprot id: A0A974CKZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SCAP family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

8355:LOC121400947
gene id: 8355:LOC121400947
uniprot id: A0A8J1MJK8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:hoxd8.L
gene id: 8355:hoxd8.L
uniprot id: A0A974BZA5
uniprot id: Q6PA92
names: Subcellular Location Annotation
messages: Nucleus

8355:sox13.S
gene id: 8355:sox13.S
uniprot id: P40649
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expression is highest in the ovary, with weak expression in other adult tissues.
messages: Homodimer.
messages: Nucleus
messages: Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3'.
messages: Was originally termed sox-12 (PubMed:8597594, PubMed:1614875).

8355:szl.S
gene id: 8355:szl.S
uniprot id: A0A8J1MPX0
uniprot id: O73821
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:xpnpep2.L
gene id: 8355:xpnpep2.L
uniprot id: A0A1L8F7N4
uniprot id: A0A974H7Q0
names: Similarity
messages: Belongs to the peptidase M24B family.

8355:grpel2.S
gene id: 8355:grpel2.S
uniprot id: A0A1L8GV88
uniprot id: A0A974HRZ3
names: Similarity
messages: Belongs to the GrpE family.

8355:ocrl.L
gene id: 8355:ocrl.L
uniprot id: A0A1L8F7G5
uniprot id: A0A8J0TK83
uniprot id: A0A974C6Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: phagosome membrane

8355:fgf3.L
gene id: 8355:fgf3.L
uniprot id: B7ZPF9
uniprot id: P36386
names: Function
names: Similarity
messages: Belongs to the heparin-binding growth factors family.
messages: Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation.

8355:suds3.L
gene id: 8355:suds3.L
uniprot id: Q6DCM3
names: Subcellular Location Annotation
messages: Nucleus

8355:mdh1.S
gene id: 8355:mdh1.S
uniprot id: A0A8J0QHB2
uniprot id: A0A974CS66
uniprot id: Q6PAB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS).
messages: Homodimer.
messages: cytosol

8355:trappc4.S
gene id: 8355:trappc4.S
uniprot id: A0A8J0U6D4
uniprot id: Q3B8F1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

8355:cacng7.L
gene id: 8355:cacng7.L
uniprot id: A0A1L8FNM9
uniprot id: A0A8J1LAA9
uniprot id: A0A974CJ47
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2.

8355:arf5.L
gene id: 8355:arf5.L
uniprot id: P51643
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alternates between an inactive GDP-bound form and an active GTP-bound form (By similarity). Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by GTPase-activating protein (GAP) (By similarity).
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Golgi apparatus membrane
messages: Small GTPase involved in protein trafficking between different compartments (By similarity). Modulates vesicle budding and uncoating within the Golgi complex (By similarity). In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane (By similarity). The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (By similarity).

8355:ate1.L
gene id: 8355:ate1.L
uniprot id: A0A8J0SYR7
uniprot id: A0A8J0T5M2
uniprot id: A0A8J0T7V8
uniprot id: A0A8J0T7W4
uniprot id: A0A8J0T8S8
uniprot id: A5PKR5
names: Function
names: Similarity
messages: Belongs to the R-transferase family.
messages: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.

8355:use1.S
gene id: 8355:use1.S
uniprot id: A0A8J1LZE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the USE1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:chrna1.2.L
gene id: 8355:chrna1.2.L
uniprot id: A0A974BZK9
uniprot id: Q6GNQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8355:sec24d.L
gene id: 8355:sec24d.L
uniprot id: A0A1L8HUY0
uniprot id: A0A974DXA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

8355:naprt.S
gene id: 8355:naprt.S
uniprot id: A0A1L8FU36
uniprot id: A0A974CM19
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

8355:lhx1.L
gene id: 8355:lhx1.L
uniprot id: A0A974DML6
uniprot id: B7ZP59
uniprot id: P29674
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: By retinoic acid and by dorsal mesoderm-inducers including activin, derriere, dvr1/vg-1 and nodal.
messages: Exhibits a biphasic expression pattern. Initially localized to the Spemann organizer region of gastrulae, leading to expression in prechordal mesoderm and notochord. In the second phase, expressed in the lateral mesoderm and neural plate, eventually concentrating in the pronephros and the CNS. Expressed in the pronephros primordium by late gastrula (stage 12.5) and becomes restricted to the tips of the tubules and ducts as kidney development progresses. In the CNS, becomes progressively recognizable in anatomically distinct structures during larval development. Within the forebrain, shows almost identical expression to lhx5 in the diencephalon, being expressed in alternating stripes to lhx2 and lhx9. Expressed in the diencephalic pretectum within prosomere 1, hypothalamus, ventral thalamus and zona limitans intrathalamica. In the telencephalon, the expression pattern is distinct from lhx5, being localized in the pallium and subpallium. Also expressed in the ventral territories of midbrain (mesencephalon) and hindbrain (rhombencephalon), being expressed in the mesencephalic tegmentum and hindbrain reticular formation. Also shows intense expression in the cerebellum including Purkinje cells.
messages: Expressed both maternally and zygotically. Expressed at a low level in the unfertilized egg. Expression is highest at the gastrula stage, then declines before rising again during the tadpole stage.
messages: Interacts with ldb1 via the tandem LIM domains. Both LIM domains are required for optimal binding and binding relieves the inhibitory effect of the LIM domains and activates lhx1. Binding to ldb1 also prevents degradation of ldb1 by rnf12. The stoichiometry of lhx1 and ldb1 is important for their function and an excess of ldb1 can inhibit lhx1 function. Interacts with the N-terminal region of rnf12 by a homeobox-dependent mechanism.
messages: Involved in the establishment of the body plan via the Spemann organizer during gastrulation. Transcriptional activator required to induce organizer gene expression downstream of siamois. Promotes head formation by binding to 5'-TAAT'-3' elements in the promoters of head organizer genes cer1 and gsc to stimulate expression. Binds as a complex with siamois and mix-A/mix.1 to the cer1 promoter, and with ldb1 and otx2 to the gsc promoter. Also involved in neural induction via the organizer, including a role in notochord formation. Acts synergistically with ldb1 and ssbp in subsequent axis formation. Involved in kidney development, acting synergistically with pax8 to establish the pronephric primordium in late gastrulae/early neurulae and with pax2 during pronephric morphogenesis in tailbud stages. Has a later role in mediating the activity of inhibitors of ventralization.
messages: Nucleus
messages: The LIM domains exert a negative regulatory function and disruption of the LIM domains produces an activated form. In addition, two activation domains and a negative regulatory domain exist C-terminally to the homeobox.

8355:polr2l.1.S
gene id: 8355:polr2l.1.S
uniprot id: A0A974HMX1
uniprot id: Q4V7P3
names: Similarity
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.

8355:ephb3.S
gene id: 8355:ephb3.S
uniprot id: A0A8J1KRS4
uniprot id: Q6NRE9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:lmbr1l.L
gene id: 8355:lmbr1l.L
uniprot id: A0A8J1M544
uniprot id: Q7ZX75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LIMR family.
messages: Cell membrane
messages: Dimer (By similarity). Can also form higher oligomers (By similarity).
messages: Endoplasmic reticulum membrane
messages: May play a role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). May act as a LCN1 receptor (By similarity).

8355:LOC108695879
gene id: 8355:LOC108695879
uniprot id: A0A8J0T6R7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108696074
gene id: 8355:LOC108696074
uniprot id: A0A1L8FIS7
uniprot id: A0A974CEJ2
names: Similarity
messages: Belongs to the PHYHIP family.

8355:epha7.S
gene id: 8355:epha7.S
uniprot id: A0A1L8G369
uniprot id: A0A8J0VFA6
uniprot id: A0A8J0VFK1
uniprot id: A0A8J0VGK0
uniprot id: A0A8J0VKY0
uniprot id: A0A8J1KTC1
uniprot id: A0A8J1KTD5
uniprot id: A0A8J1KTD7
uniprot id: A0A974CT94
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:nmnat2.S
gene id: 8355:nmnat2.S
uniprot id: A0A8J1KMI4
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

8355:LOC108711134
gene id: 8355:LOC108711134
uniprot id: A0A1L8GYS9
uniprot id: A0A1L8GYT7
uniprot id: A0A974DBI1
uniprot id: A0A974DBI7
names: Similarity
messages: Belongs to the MDFI family.

8355:spns1.L
gene id: 8355:spns1.L
uniprot id: Q5XGK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Lysosome membrane
messages: Mediates the rate-limiting, proton-dependent, lysosomal efflux of lysophospholipids. Selective for zwitterionic headgroups such as lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE) (By similarity). Essential player in lysosomal homeostasis (By similarity).

8355:gli3.L
gene id: 8355:gli3.L
uniprot id: A0A1L8FWR2
uniprot id: A0A8J1KVA0
uniprot id: A0A974CM47
uniprot id: Q91660
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and may play a role in limb development. May bind to the minimal GLI-consensus sequence 5'-GGGTGGTC-3' (By similarity). Has an essential role in the early embryonic patterning of mesoderm and neuroectoderm.
messages: Nucleus
messages: Phosphorylation is essential for its proteolytic processing.
messages: The repressor form (GLI3R), a C-terminally truncated form is generated from the full-length GLI3 protein (GLI3FL) through proteolytic processing.

8355:septin10.S
gene id: 8355:septin10.S
uniprot id: A0A1L8H8P4
uniprot id: A0A974DI66
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

8355:myt1.L
gene id: 8355:myt1.L
uniprot id: A0A8J0TIN6
uniprot id: A0A8J0TQC3
uniprot id: A0A8J0TRB6
uniprot id: A0A8J0TSD8
uniprot id: A0A8J0TTF1
uniprot id: A0A8J1LQI4
uniprot id: B7ZRR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

8355:LOC121400440
gene id: 8355:LOC121400440
uniprot id: A0A8J1MDP4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108699962
gene id: 8355:LOC108699962
uniprot id: A0A1L8F1H5
uniprot id: A0A8J0TGA8
uniprot id: A0A8J0TMT4
uniprot id: A0A8J0TNZ3
uniprot id: A0A8J0TNZ7
uniprot id: A0A8J0TPX5
uniprot id: A0A8J0TPY0
uniprot id: A0A8J0TQZ5
uniprot id: A0A974C2W9
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

8355:thumpd3.L
gene id: 8355:thumpd3.L
uniprot id: A0A1L8GPM8
uniprot id: A0A8J1MY79
uniprot id: A0A974D7M1
names: Similarity
messages: Belongs to the methyltransferase superfamily.

8355:hba1.L
gene id: 8355:hba1.L
uniprot id: A0A974BZS2
uniprot id: P02012
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.
messages: Red blood cells.

8355:vcp.L
gene id: 8355:vcp.L
uniprot id: A0A8J1LA55
names: Similarity
messages: Belongs to the AAA ATPase family.

8355:atp1b1.S
gene id: 8355:atp1b1.S
uniprot id: A0A974HVA1
uniprot id: Q91580
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

8355:pdhx.L
gene id: 8355:pdhx.L
uniprot id: Q68FJ5
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

8355:alox5ap.S
gene id: 8355:alox5ap.S
uniprot id: A0A1L8HAI9
uniprot id: A0A974DLW9
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:pi4ka.L
gene id: 8355:pi4ka.L
uniprot id: A0A1L8I0J8
uniprot id: A0A8J0V8M1
uniprot id: A0A974I5F5
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

8355:metap1d.L
gene id: 8355:metap1d.L
uniprot id: A0A1L8EW64
uniprot id: A0A8J0TUL9
uniprot id: A0A8J0TV39
uniprot id: A0A8J0TW90
uniprot id: A0A974BZG7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

8355:hoxa11.S
gene id: 8355:hoxa11.S
uniprot id: A0A1L8FW43
uniprot id: A0A974CNG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

8355:cdc34.S
gene id: 8355:cdc34.S
uniprot id: A0A1L8HNQ2
uniprot id: A0A974DUX7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8355:fkrp.L
gene id: 8355:fkrp.L
uniprot id: A0A1L8F835
uniprot id: A0A974H7G1
names: Similarity
messages: Belongs to the LicD transferase family.

8355:LOC108705672
gene id: 8355:LOC108705672
uniprot id: A0A1L8G0S1
uniprot id: A0A974HIZ7
uniprot id: P84233
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by rag1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:sec16a.L
gene id: 8355:sec16a.L
uniprot id: A0A1L8F634
uniprot id: A0A8J0T9D1
uniprot id: A0A8J0TFE9
uniprot id: A0A8J0TI06
uniprot id: A0A8J0TIW6
uniprot id: A0A8J0TIX3
uniprot id: A0A974C5R0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC16 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.
messages: SEC16A and SEC16B are each present in multiple copies in a heteromeric complex.

8355:nfatc3.S
gene id: 8355:nfatc3.S
uniprot id: Q8QHM1
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108707623
gene id: 8355:LOC108707623
uniprot id: A0A8J1MAK5
uniprot id: A0A8J1MBK8
uniprot id: A0A8J1MCC9
names: Subcellular Location Annotation
messages: Nucleus

8355:ventx2.2.L
gene id: 8355:ventx2.2.L
uniprot id: Q91914
names: Subcellular Location Annotation
messages: Nucleus

8355:plppr4.S
gene id: 8355:plppr4.S
uniprot id: A0A1L8GG72
uniprot id: A0A974D1X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

8355:neu4.S
gene id: 8355:neu4.S
uniprot id: A0A8J0VAY4
uniprot id: A0A8J1KUE5
uniprot id: A0A8J1KVZ7
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

8355:ngfr.L
gene id: 8355:ngfr.L
uniprot id: A0A974H269
uniprot id: Q9PRG7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:dazap2.S
gene id: 8355:dazap2.S
uniprot id: A0A974DLE3
uniprot id: Q6GN36
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle
messages: nuclear body

8355:pkmyt1.S
gene id: 8355:pkmyt1.S
uniprot id: Q91618
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.
messages: Autophosphorylated. Phosphorylated on undefined residues by RSK2 and Mos kinases. Phosphorylation at Thr-478 by cdk1 creates a docking site for plk1/plx1, leading to subsequent phosphorylation by plk1/plk1 and inhibition of the protein kinase activity kinase activity.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Interacts with CDC2-CCNB1 complex (By similarity). Interacts with Mos during oocyte maturation.
messages: Negatively regulated by hyperphosphorylation during mitosis. The plk1/plk1 protein kinase may be required for mitotic phosphorylation. Inactivated during oocyte maturation by phosphorylation by RSK2 and Mos kinase.

8355:ebf3.S
gene id: 8355:ebf3.S
uniprot id: A0A8J0T5P7
uniprot id: A0A8J0T5Q3
uniprot id: A0A8J0TBR2
uniprot id: A0A8J0TBS6
uniprot id: A0A8J0TDQ9
uniprot id: A0A8J0TDR3
uniprot id: A0A8J0TEI5
uniprot id: A0A8J0TEJ1
uniprot id: A0A8J0TF51
uniprot id: A0A8J0TF56
uniprot id: A0A8J1LBC9
uniprot id: A0A8J1LBD5
uniprot id: A0A8J1LBD8
uniprot id: A0A8J1LBH8
uniprot id: A0A8J1LBI2
uniprot id: A0A8J1LCY4
uniprot id: A0A8J1LCZ2
uniprot id: A0A8J1LDV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

8355:naf1.L
gene id: 8355:naf1.L
uniprot id: A0A8J0TCY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAF1 family.
messages: Nucleus

8355:LOC121399708
gene id: 8355:LOC121399708
uniprot id: A0A8J1M664
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:srf.L
gene id: 8355:srf.L
uniprot id: A0A8J0V7X3
uniprot id: B7ZPQ5
uniprot id: P23790
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds DNA as a multimer, probably a dimer.
messages: Nucleus
messages: SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration.

8355:nrdc.S
gene id: 8355:nrdc.S
uniprot id: A0A1L8GFX3
uniprot id: A0A974CZD8
names: Similarity
messages: Belongs to the peptidase M16 family.

8355:hes4.S
gene id: 8355:hes4.S
uniprot id: Q90Z12
names: Caution
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Sequence Caution
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: By Notch-signaling. Acts in a complex regulatory loop with other bHLH proteins.
messages: Expressed both maternally and zygotically. Shows lower zygotic expression than hes4-B/hairy2b.
messages: Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
messages: Multiple papers report expression in the developing neural crest and a role in neural crest formation. However, PubMed:17724611 reports differences between the duplicated hes4 gene products and shows that hes4-B/hairy2b but not hes4-A/hairy2a has a role in neural crest formation, and that hes4-B/hairy2b but not hes4-A/hairy2a is expressed in the presumptive neural crest.
messages: Nucleus
messages: Probable intron retention at N-terminus and possible frameshift and contaminating sequence at C-terminus.
messages: Shows a complex and dynamic expression pattern in developing embryos. In neurulae, expressed in the presumptive floor plate, the anterior part of the prechordal plate and in the anterior neural border. In tailbud embryos, expressed in various neuroectoderm derivatives and in the mesoderm, where expression is limited to the presomitic mesoderm (PSM) and pronephros. In the PSM, expressed in an anterior stripe prior to the formation of each somite. Expression in the presumptive neural crest is disputed.
messages: The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
messages: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family. Binds DNA in the form of a heterodimer with the bHLH protein hey1/hrt1. Interacts (via Orange domain) with id3 (via HLH domain) (By similarity). Interacts with the bHLH protein hes6; this interaction may inhibit the transcriptional repressor activity.
messages: Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'. Plays a role in the patterning of tissue boundaries. Promotes floor plate development and prechordal plate development. Required for lens development as early as the stage of lens field formation, partly through regulation of gene expression of the cell cycle inhibitor cdknx/p27(xic1). A role in neural crest development is disputed.

8355:got2.L
gene id: 8355:got2.L
uniprot id: Q7SZS3
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

8355:tmc7.L
gene id: 8355:tmc7.L
uniprot id: A0A8J1LUX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

8355:dhcr7.L
gene id: 8355:dhcr7.L
uniprot id: A0A1L8GIE0
uniprot id: Q7SYZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

8355:vwde.L
gene id: 8355:vwde.L
uniprot id: A0A1L8FVU5
uniprot id: A0A8J0VG86
uniprot id: A0A8J1KX21
uniprot id: A0A8J1KX30
uniprot id: A0A974HF65
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:stab2.L
gene id: 8355:stab2.L
uniprot id: A0A8J0UQQ3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:galns.L
gene id: 8355:galns.L
uniprot id: A0A8J1MU86
uniprot id: Q5XG10
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Homodimer.
messages: Lysosome

8355:tomm20.S
gene id: 8355:tomm20.S
uniprot id: A0A8J0U8H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

8355:tmem165.S
gene id: 8355:tmem165.S
uniprot id: A0A1L8HL78
uniprot id: A0A8J0U011
uniprot id: A0A974DRM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

8355:stt3a.S
gene id: 8355:stt3a.S
uniprot id: A0A1L8FFS2
uniprot id: A0A8J0T6G3
uniprot id: A0A974CC53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

8355:gpr155.S
gene id: 8355:gpr155.S
uniprot id: A0A1L8EP87
uniprot id: A0A8J1LY74
uniprot id: A0A974BUN1
uniprot id: Q6GNL6
names: Subcellular Location Annotation
messages: Membrane

8355:tcirg1.L
gene id: 8355:tcirg1.L
uniprot id: A0A1L8FKQ1
uniprot id: A0A974CFP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

8355:LOC108716930
gene id: 8355:LOC108716930
uniprot id: A0A1L8I149
uniprot id: A0A974E3N9
names: Subcellular Location Annotation
messages: Membrane

8355:arid3b.L
gene id: 8355:arid3b.L
uniprot id: A0A1L8H083
uniprot id: A0A8J0UJR2
uniprot id: A0A974DED7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer.
messages: Nucleus
messages: Transcription factor.

8355:LOC108698775
gene id: 8355:LOC108698775
uniprot id: A0A8J1LHF0
uniprot id: A0A8J1LHJ0
uniprot id: A0A8J1LI17
uniprot id: A0A8J1LI23
uniprot id: A0A8J1LIT8
uniprot id: A0A8J1LIU4
uniprot id: A0A8J1LJW9
uniprot id: A0A8J1LJX4
names: Similarity
messages: Belongs to the WD repeat EMAP family.

8355:crp.L
gene id: 8355:crp.L
uniprot id: A0A1L8GPD1
uniprot id: A0A974D4Z6
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:LOC121403061
gene id: 8355:LOC121403061
uniprot id: A0A8J1MYT5
names: Similarity
messages: Belongs to the HARBI1 family.

8355:snx31.L
gene id: 8355:snx31.L
uniprot id: A0A1L8FZJ3
uniprot id: A0A8J0VKH2
uniprot id: A0A974CQX9
names: Similarity
messages: Belongs to the sorting nexin family.

8355:set.S
gene id: 8355:set.S
uniprot id: A0A8J0TL34
uniprot id: A0A8J1LN00
uniprot id: A0A974C365
uniprot id: Q9PVV6
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

8355:nphs2.L
gene id: 8355:nphs2.L
uniprot id: A0A1L8GMP3
uniprot id: A0A974D6J9
names: Similarity
messages: Belongs to the band 7/mec-2 family.

8355:atic.S
gene id: 8355:atic.S
uniprot id: A0A8J0U0U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PurH family.
messages: cytosol

8355:gdf7.L
gene id: 8355:gdf7.L
uniprot id: A0A1L8GBP5
uniprot id: A0A974HKM5
names: Similarity
messages: Belongs to the TGF-beta family.

8355:cacnb3.L
gene id: 8355:cacnb3.L
uniprot id: A0A8J1M4Y4
uniprot id: Q91629
names: Subcellular Location Annotation
messages: Cytoplasm

8355:dynlt4.S
gene id: 8355:dynlt4.S
uniprot id: A0A1L8GFN9
uniprot id: A0A974D099
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

8355:c8orf82.S
gene id: 8355:c8orf82.S
uniprot id: A0A1L8FU67
uniprot id: A0A974CKK5
names: Similarity
messages: Belongs to the UPF0598 family.

8355:kcnj5.S
gene id: 8355:kcnj5.S
uniprot id: A0A8J0TFU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

8355:mcm7.L
gene id: 8355:mcm7.L
uniprot id: Q7ZXB1
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. The existence of maternal and zygotic forms of mcm3 and mcm6 suggests that specific forms of mcm2-7 complexes may be used during different stages of development (By similarity).
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the mcm2-7 complex (RLF-M) (By similarity). The complex forms a toroidal hexameric ring with the proposed subunit order mcm2-mcm6-mcm4-mcm7-mcm3-mcm5 (By similarity). The heterodimer of mmcm3/mcm5 interacts with mcm4, mmcm6, mcm7 and weakly with mcm2 (By similarity). The N-terminus is required for interaction with mmcm3, though this interaction may not be direct, and remains in a complex with mmcm3 throughout the cell cycle (By similarity). Begins to associate with zmcm6 at the neurula stage (By similarity). Component of the replisome complex (By similarity). Component of the CMG helicase complex, composed of the mcm2-7 complex, the GINS complex and cdc45 (By similarity).
messages: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.
messages: Nucleus
messages: Ubiquitinated by traip when forks converge following formation of DNA interstrand cross-links (By similarity). Short ubiquitin chains on mcm7 promote recruitment of DNA glycosylase neil3 (By similarity). If the interstrand cross-link cannot be cleaved by neil3, the ubiquitin chains continue to grow on mcm7, promoting the unloading of the CMG helicase complex by the vcp/p97 ATPase (By similarity).

8355:LOC108708418
gene id: 8355:LOC108708418
uniprot id: A0A1L8HGR8
uniprot id: A0A974DPS5
names: Similarity
messages: Belongs to the CFAP97 family.

8355:rtn4.L
gene id: 8355:rtn4.L
uniprot id: A0A1L8G5R6
uniprot id: A0A8J0VDL2
uniprot id: A0A8J1KL61
uniprot id: A0A8J1KL66
uniprot id: A0A8J1KL84
uniprot id: A0A8J1KMW4
uniprot id: A0A8J1KPB0
uniprot id: A0A974HII8
uniprot id: A5D8Q6
uniprot id: Q6JRV8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:LOC108695735
gene id: 8355:LOC108695735
uniprot id: A0A8J1L644
uniprot id: A0A8J1L649
uniprot id: A0A8J1L659
uniprot id: A0A8J1L7T9
uniprot id: A0A8J1L7V0
uniprot id: A0A8J1L7V6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

8355:tnfsf15.S
gene id: 8355:tnfsf15.S
uniprot id: A0A8J0TQA7
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8355:mfsd14bl.S
gene id: 8355:mfsd14bl.S
uniprot id: A0A1L8HPH2
uniprot id: A0A974DU59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

8355:atg3.S
gene id: 8355:atg3.S
uniprot id: Q6GQE7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG3 family.
messages: Conjugated to atg12 at Lys-242. ATG12-conjugation plays a role in regulation of mitochondrial homeostasis and cell death, while it is not involved in PE-conjugation to ATG8-like proteins and autophagy (By similarity).
messages: Cytoplasm
messages: E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of atg8-like proteins (gabarap, gabarapl1, gabarapl2 or map1lc3a). The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8-like proteins from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8-like proteins. The formation of the atg8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of atg12 to itself, atg12 conjugation to atg3 playing a role in mitochondrial homeostasis but not in autophagy. atg7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with atg3 (By similarity).
messages: Interacts with atg7 and atg12. The complex composed of atg3 and atg7 plays a role in the conjugation of atg12 to atg5.

8355:XB5780651.S
gene id: 8355:XB5780651.S
uniprot id: A0A8J0ULZ2
names: Subcellular Location Annotation
messages: Membrane

8355:gipc3.S
gene id: 8355:gipc3.S
uniprot id: A0A8J0U7T7
names: Similarity
messages: Belongs to the GIPC family.

8355:xpot.S
gene id: 8355:xpot.S
uniprot id: A0A1L8GUL4
uniprot id: A0A8J0UXP6
uniprot id: A0A974DAX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.

8355:LOC108716775
gene id: 8355:LOC108716775
uniprot id: A0A1L8G8W8
uniprot id: A0A974CX52
names: Similarity
messages: Belongs to the LCA5 family.

8355:coro6.L
gene id: 8355:coro6.L
uniprot id: A0A1L8HD65
uniprot id: A0A8J0UGH2
uniprot id: A0A974DL72
names: Similarity
messages: Belongs to the WD repeat coronin family.

8355:LOC108716035
gene id: 8355:LOC108716035
uniprot id: A0A1L8I0D9
uniprot id: A0A974I4X0
names: Similarity
messages: Belongs to the GST superfamily. Theta family.

8355:LOC121396292
gene id: 8355:LOC121396292
uniprot id: A0A8J1KUR7
uniprot id: A0A8J1KW79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

8355:dnajc24.S
gene id: 8355:dnajc24.S
uniprot id: A0A1L8GD87
names: Similarity
messages: Belongs to the DPH4 family.

8355:adam11.L
gene id: 8355:adam11.L
uniprot id: A0A1L8ESA9
uniprot id: A0A974BWW1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:rpl11.S
gene id: 8355:rpl11.S
uniprot id: A0A310UEC1
uniprot id: A0A974BRQ9
uniprot id: A0A974BRV7
uniprot id: Q66KY6
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

8355:LOC121401278
gene id: 8355:LOC121401278
uniprot id: A0A1L8H2B8
names: Subcellular Location Annotation
messages: Membrane

8355:tmem56.2.S
gene id: 8355:tmem56.2.S
uniprot id: A0A8J0U1W0
names: Subcellular Location Annotation
messages: Membrane

8355:spdef.S
gene id: 8355:spdef.S
uniprot id: A0A1L8H6T5
uniprot id: A0A8J0UC22
uniprot id: A0A974HVP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8355:LOC121401327
gene id: 8355:LOC121401327
uniprot id: A0A8J1MJH3
names: Subcellular Location Annotation
messages: Membrane

8355:prpf4.L
gene id: 8355:prpf4.L
uniprot id: A0A1L8F5Q2
uniprot id: A0A8J0TGX0
uniprot id: A0A974C5J2
uniprot id: A0A974C5L1
uniprot id: Q66J65
names: Subcellular Location Annotation
messages: Nucleus speckle

8355:mex3d.L
gene id: 8355:mex3d.L
uniprot id: A0A1L8HWD3
uniprot id: A0A974DY80
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:ptdss2.L
gene id: 8355:ptdss2.L
uniprot id: B5DE41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:slc34a3.S
gene id: 8355:slc34a3.S
uniprot id: A0A1L8F0N8
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

8355:LOC108709451
gene id: 8355:LOC108709451
uniprot id: A0A8J0UK56
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
messages: Enterostatin has a biological activity as a satiety signal.
messages: Forms a 1:1 stoichiometric complex with pancreatic lipase.
messages: Secreted

8355:dock1.S
gene id: 8355:dock1.S
uniprot id: A0A1L8FEC5
uniprot id: A0A8J1LBD4
uniprot id: A0A8J1LBI6
uniprot id: A0A8J1LCZ6
uniprot id: A0A974H9N5
names: Similarity
messages: Belongs to the DOCK family.

8355:zfhx3.S
gene id: 8355:zfhx3.S
uniprot id: A0A1L8GF44
uniprot id: A0A974D162
names: Subcellular Location Annotation
messages: Nucleus

8355:znf687.L
gene id: 8355:znf687.L
uniprot id: A0A8J0TLS5
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

8355:XB5832479.S
gene id: 8355:XB5832479.S
uniprot id: A0A8J0TB27
uniprot id: A0A8J0TDT1
uniprot id: Q640B7
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

8355:LOC121400931
gene id: 8355:LOC121400931
uniprot id: A0A8J1MHM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:cox16.L
gene id: 8355:cox16.L
uniprot id: A0A1L8FAQ9
uniprot id: A0A8J0TLR0
uniprot id: A0A974C8S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Membrane
messages: Mitochondrion inner membrane

8355:XB5832479.L
gene id: 8355:XB5832479.L
uniprot id: A0A1L8FJF3
uniprot id: A0A974CEG2
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

8355:leprotl1.S
gene id: 8355:leprotl1.S
uniprot id: A0A974DU76
uniprot id: Q7ZY41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

8355:cnpy1.L
gene id: 8355:cnpy1.L
uniprot id: A0A1L8FV61
uniprot id: A0A974CME9
names: Similarity
messages: Belongs to the canopy family.

8355:kiaa1522.S
gene id: 8355:kiaa1522.S
uniprot id: A0A310U7A3
uniprot id: A0A8J0TY45
uniprot id: A0A974BRR7
names: Similarity
messages: Belongs to the NHS family.

8355:LOC108702867
gene id: 8355:LOC108702867
uniprot id: A0A8J0U317
uniprot id: A0A8J1LX59
names: Subcellular Location Annotation
messages: Cleavage furrow
messages: Endosome membrane
messages: Membrane
messages: Midbody
messages: Recycling endosome membrane

8355:LOC108708306
gene id: 8355:LOC108708306
uniprot id: A0A974DQ20
uniprot id: Q8AVH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
messages: Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin.
messages: Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism.
messages: Nucleus

8355:stx1a.S
gene id: 8355:stx1a.S
uniprot id: A0A8J1MD63
uniprot id: A0A8J1MDQ5
names: Similarity
messages: Belongs to the syntaxin family.

8355:slc33a1.S
gene id: 8355:slc33a1.S
uniprot id: A0A1L8G4A6
uniprot id: A0A974CSS2
names: Subcellular Location Annotation
messages: Membrane

8355:chrna7.L
gene id: 8355:chrna7.L
uniprot id: A0A1L8H099
uniprot id: A0A974DCQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8355:megf10.S
gene id: 8355:megf10.S
uniprot id: A0A8J1M4Y2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:alyref.S
gene id: 8355:alyref.S
uniprot id: Q6GLW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation.
messages: Belongs to the ALYREF family.
messages: Component of the transcription/export (TREX) complex; TREX seems to have a dynamic structure involving ATP-dependent remodeling (By similarity).
messages: Cytoplasm
messages: Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm. Involved in the nuclear export of intronless mRNA. Involved in transcription elongation and genome stability (By similarity).
messages: Nucleus
messages: Nucleus speckle

8355:mef2d.S
gene id: 8355:mef2d.S
uniprot id: A0A8J0TNC7
uniprot id: A0A8J1LKI4
uniprot id: A0A974H6B5
uniprot id: B7ZQS1
uniprot id: Q03413
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MEF2 family.
messages: Binds DNA as a multimer, probably as a dimer. Interacts with hdac9.
messages: Expression begins in the late gastrula.
messages: May regulate muscle-specific transcription in the embryo and may regulate transcription of a variety of cell types in the adult. It binds to the sequence 5'-CTA[TA]4TAR-3'.
messages: Nucleus
messages: Restricted to the somitic mesoderm of early embryos and to the body muscle (myotomes) of the tadpole. Expressed in all tissues examined in the adult.

8355:wars1.L
gene id: 8355:wars1.L
uniprot id: A0A974H8B5
uniprot id: Q6NUA2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

8355:rap2b.L
gene id: 8355:rap2b.L
uniprot id: A0A1L8GAX7
uniprot id: A0A974CYL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Recycling endosome membrane

8355:kars1.S
gene id: 8355:kars1.S
uniprot id: A0A1L8GF86
uniprot id: A0A974D0Z8
uniprot id: Q7ZWY9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

8355:epo.L
gene id: 8355:epo.L
uniprot id: A0A8J0ULV1
uniprot id: A0A8J0USQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPO/TPO family.
messages: Secreted

8355:zc3h15.S
gene id: 8355:zc3h15.S
uniprot id: A0A1L8EPZ9
uniprot id: A0A8J1LWX6
uniprot id: A0A974BVD3
names: Similarity
messages: Belongs to the ZC3H15/TMA46 family.

8355:LOC121400028
gene id: 8355:LOC121400028
uniprot id: A0A8J1MBB2
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:rbm47.L
gene id: 8355:rbm47.L
uniprot id: A0A1L8HTS8
uniprot id: A0A8J0TI13
uniprot id: A0A8J1MSZ8
uniprot id: A0A974DXN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM RBM47 family.
messages: Cytoplasm
messages: Nucleus

8355:LOC108699967
gene id: 8355:LOC108699967
uniprot id: A0A1L8F1M8
uniprot id: A0A974H5N2
names: Subcellular Location Annotation
messages: cytosol

8355:scgn.L
gene id: 8355:scgn.L
uniprot id: A0A8J1KVX7
uniprot id: A0A8J1KYY2
uniprot id: Q63ZJ3
names: Subcellular Location Annotation
messages: Cytoplasm

8355:LOC108710401
gene id: 8355:LOC108710401
uniprot id: A0A8J1MIM3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:aars1.L
gene id: 8355:aars1.L
uniprot id: B1WBD3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Monomer. Interacts with ANKRD16; the interaction is direct.

8355:pgat.L
gene id: 8355:pgat.L
uniprot id: O73622
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: An mRNA and protein component of germ plasm and primordial germ cells (PGCs) throughout oogenesis and early development, being first localized to the granulo-fibrillar material (GFM) of the mitochondrial cloud in stage I and II oocytes and to the periphery of mature germinal granules both in oocytes and in embryos. Shows some somatic expression including the ectodermal cells of tailbud embryos. In adults, only expressed in ovaries.
messages: Cytoplasm
messages: Expressed both maternally and zygotically from at least the pre-vitellogenic stage I of oogenesis through to the tadpole stages.
messages: Interacts with poc1b.
messages: Nucleus
messages: Probably plays a role in germ plasm formation, positioning and maintenance.

8355:LOC108709067
gene id: 8355:LOC108709067
uniprot id: A0A1L8H4R3
uniprot id: A0A8J0ULQ5
uniprot id: A0A974HUZ7
names: Subcellular Location Annotation
messages: Membrane

8355:shroom4.L
gene id: 8355:shroom4.L
uniprot id: A0A1L8F6N4
uniprot id: A0A8J0TI15
uniprot id: A0A8J1LHG4
uniprot id: A0A974C5Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

8355:cep70.L
gene id: 8355:cep70.L
uniprot id: Q5HZ81
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.
messages: Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
messages: centrosome

8355:mrpl28.L
gene id: 8355:mrpl28.L
uniprot id: A0A1L8EXB7
uniprot id: A0A974H3Y8
uniprot id: Q68EV6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL28 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

8355:LOC108700469
gene id: 8355:LOC108700469
uniprot id: A0A8J1LQV4
names: Subcellular Location Annotation
names: Subunit
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.

8355:gabra5.L
gene id: 8355:gabra5.L
uniprot id: A0A1L8HGW6
uniprot id: A0A974HZ00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8355:LOC108703878
gene id: 8355:LOC108703878
uniprot id: A0A8J1LTR4
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8355:ebag9.L
gene id: 8355:ebag9.L
uniprot id: A0A974HGX0
uniprot id: Q6DJE6
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.

8355:eftud2.S
gene id: 8355:eftud2.S
uniprot id: A0A974H097
uniprot id: Q7ZXZ9
names: Subcellular Location Annotation
messages: Nucleus

8355:rbp4.L
gene id: 8355:rbp4.L
uniprot id: A0A974CEQ8
uniprot id: Q6NUG9
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

8355:LOC108701205
gene id: 8355:LOC108701205
uniprot id: A0A1L8EUY4
uniprot id: A0A8J0TTR8
uniprot id: A0A974H3K4
names: Subcellular Location Annotation
messages: Cytoplasm

8355:hoxd10.S
gene id: 8355:hoxd10.S
uniprot id: A0A1L8EP98
uniprot id: A0A974H1Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

8355:dis3l2.S
gene id: 8355:dis3l2.S
uniprot id: A0A1L8G451
uniprot id: A0A8J0VFY9
uniprot id: A0A974CU40
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation.
messages: Belongs to the RNR ribonuclease family. DIS3L2 subfamily.
messages: Cytoplasm
messages: P-body
messages: Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site.

8355:LOC108701935
gene id: 8355:LOC108701935
uniprot id: A0A8J1LRU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:pnpla6.L
gene id: 8355:pnpla6.L
uniprot id: A0A1L8F5S9
uniprot id: A0A8J1LFP0
uniprot id: A0A974H736
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:nxph4.L
gene id: 8355:nxph4.L
uniprot id: A0A8J0U8H3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

8355:hyal1.L
gene id: 8355:hyal1.L
uniprot id: A0A1L8GP88
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

8355:pigf.L
gene id: 8355:pigf.L
uniprot id: A0A1L8G5Y6
uniprot id: A0A974CTD7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:sstr1.S
gene id: 8355:sstr1.S
uniprot id: A0A1L8EZP2
uniprot id: A0A974C1E6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:LOC108701821
gene id: 8355:LOC108701821
uniprot id: A0A8J0TZJ2
names: Similarity
messages: Belongs to the FAM20 family.

8355:casd1.L
gene id: 8355:casd1.L
uniprot id: A0A1L8FVW6
uniprot id: A0A974HF80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PC-esterase family. CASD1 subfamily.
messages: Membrane

8355:bmp6.S
gene id: 8355:bmp6.S
uniprot id: Q52L10
names: Similarity
messages: Belongs to the TGF-beta family.

8355:abcc13.L
gene id: 8355:abcc13.L
uniprot id: A0A1L8HCT7
uniprot id: A0A8J1M771
uniprot id: A0A974DL34
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108702681
gene id: 8355:LOC108702681
uniprot id: A0A1L8EM17
uniprot id: A0A8J1LZK1
uniprot id: A0A974H0J6
names: Subcellular Location Annotation
messages: Membrane

8355:aox1.S
gene id: 8355:aox1.S
uniprot id: Q6GMC5
names: Cofactor
names: Similarity
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.

8355:LOC108715777
gene id: 8355:LOC108715777
uniprot id: A0A1L8GH59
uniprot id: A0A974D2E6
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:vopp1.L
gene id: 8355:vopp1.L
uniprot id: A0A1L8FWQ3
uniprot id: A0A974HFH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VOPP1/ECOP family.
messages: Cytoplasmic vesicle membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

8355:pam16.L
gene id: 8355:pam16.L
uniprot id: A0A974H483
uniprot id: Q6NTU3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM16/PAM16 family.
messages: Mitochondrion inner membrane
messages: Probable component of the PAM complex at least composed of 1 mitochondrial HSP70 protein, 1 GRPE, 1 TIMM44, 1 TIMM16/PAM16 and 1 TIMM14. Associates with the TIM23 complex.
messages: Regulates ATP-dependent protein translocation into the mitochondrial matrix.
messages: The J-like region, although related to the J domain does not have co-chaperone activity.

8355:rab19.L
gene id: 8355:rab19.L
uniprot id: A0A1L8GW69
uniprot id: A0A974HS05
uniprot id: Q32NQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

8355:znf408.S
gene id: 8355:znf408.S
uniprot id: A0A1L8GE41
uniprot id: A0A974HLF4
names: Subcellular Location Annotation
messages: Nucleus

8355:hnrnpab.S
gene id: 8355:hnrnpab.S
uniprot id: A0A8J1MNQ4
uniprot id: A0A974DAK5
uniprot id: Q6GM69
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:LOC108704485
gene id: 8355:LOC108704485
uniprot id: A0A8J0U447
uniprot id: A0A8J1LIJ2
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

8355:LOC108708329
gene id: 8355:LOC108708329
uniprot id: A0A1L8HGB3
uniprot id: A0A974HYZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

8355:krt12.5.S
gene id: 8355:krt12.5.S
uniprot id: A0A8J1LW86
uniprot id: A0A974BSJ7
uniprot id: Q4QR57
names: Similarity
messages: Belongs to the intermediate filament family.

8355:lamb2.L
gene id: 8355:lamb2.L
uniprot id: A0A1L8GPU6
uniprot id: Q5XHI6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

8355:ropn1l.L
gene id: 8355:ropn1l.L
uniprot id: A0A974HFN9
uniprot id: Q4V7T8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ropporin family.
messages: Component of axonemal radial spoke complexes (By similarity).
messages: Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia. Important for male fertility. Involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.
messages: cilium
messages: flagellum

8355:LOC108695637
gene id: 8355:LOC108695637
uniprot id: A0A8J0SZ43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8355:sp4.S
gene id: 8355:sp4.S
uniprot id: A0A1L8FR54
uniprot id: A0A8J0VM33
uniprot id: A0A8J1L1L4
uniprot id: A0A974HDK9
names: Subcellular Location Annotation
messages: Nucleus

8355:adcyap1.L
gene id: 8355:adcyap1.L
uniprot id: A0A8J0VEF1
uniprot id: A0A974CNV9
uniprot id: Q9PUF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

8355:LOC108710523
gene id: 8355:LOC108710523
uniprot id: A0A1L8H4H2
uniprot id: A0A974DH97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:tspan15.L
gene id: 8355:tspan15.L
uniprot id: A0A974C7Y3
uniprot id: Q6GN81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8355:rtraf.S
gene id: 8355:rtraf.S
uniprot id: A0A8J0TF02
uniprot id: Q5M9B0
names: Similarity
messages: Belongs to the RTRAF family.

8355:LOC108705644
gene id: 8355:LOC108705644
uniprot id: A0A8J1KNW9
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

8355:tent5a.S
gene id: 8355:tent5a.S
uniprot id: A0A1L8G3D3
uniprot id: A0A974HHP2
names: Similarity
messages: Belongs to the TENT family.

8355:LOC108700685
gene id: 8355:LOC108700685
uniprot id: A0A8J1LLH4
uniprot id: A0A8J1LMC1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108699040
gene id: 8355:LOC108699040
uniprot id: A0A1L8FBJ7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:kif2c.L
gene id: 8355:kif2c.L
uniprot id: A0A1L8GM91
uniprot id: A0A8J0UWU7
uniprot id: A0A8J1MX57
uniprot id: A0A8J1MY30
uniprot id: A0A974HPD4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8355:uqcrfs1.L
gene id: 8355:uqcrfs1.L
uniprot id: A0A974HNH5
uniprot id: Q05AU1
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

8355:wt1.L
gene id: 8355:wt1.L
uniprot id: A0A8J1MUN6
uniprot id: P79958
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3' via its C2H2-type zinc fingers. Starting from the N-terminus, the second zinc finger binds to the 3'-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5'-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine, 5-formylcytosine or 5-carboxylcytosine.
messages: Cytoplasm
messages: Expressed in the pronephric anlage from stage 23 to 30. Also expressed in the adult kidney (mesonephros) and in testis.
messages: Nucleus
messages: Nucleus speckle
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor required for development of the vascular component of the pronephric kidney, the glomus; may repress tubule-specific gene expression in the portion of the pronephros fated to form the glomus (PubMed:16818449). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (By similarity). Inhibits Wnt-signaling during embryonic development (By similarity).

8355:slc44a2.L
gene id: 8355:slc44a2.L
uniprot id: A0A8J0UFH2
uniprot id: A0A8J0UM43
uniprot id: A0A8J0UND2
uniprot id: Q6IP59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Choline/H+ antiporter, mainly in mitochodria. Also acts as a low-affinity ethanolamine/H+ antiporter, regulating the supply of extracellular ethanolamine (Etn) for the CDP-Etn pathway, redistribute intracellular Etn and balance the CDP-Cho and CDP-Etn arms of the Kennedy pathway.
messages: Membrane
messages: Mitochondrion outer membrane

8355:LOC121397637
gene id: 8355:LOC121397637
uniprot id: A0A8J1LM28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:ipo7.L
gene id: 8355:ipo7.L
uniprot id: O42480
uniprot id: Q7ZWZ8
names: Subcellular Location Annotation
messages: Cytoplasm

8355:serpina1.L
gene id: 8355:serpina1.L
uniprot id: Q9YIB8
names: Similarity
messages: Belongs to the serpin family.

8355:slc4a9.L
gene id: 8355:slc4a9.L
uniprot id: A0A1L8GXA2
uniprot id: A0A974DDB7
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

8355:mcm6.2.L
gene id: 8355:mcm6.2.L
uniprot id: A0A8J0TRM8
uniprot id: Q498J7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. The existence of maternal and zygotic forms of mcm3 and mcm6 suggests that specific forms of mcm2-7 complexes may be used during different stages of development. May replace mmcm6 in the mcm2-7 complex.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Component of the mcm2-7 complex (RLF-M). The complex forms a toroidal hexameric ring with the proposed subunit order mcm2-mcm6-mcm4-mcm7-mcm3-mcm5 (By simililarity). Begins to associate with zmcm3, mcm4 and mcm7 into mcm complexes at the neurula stage. May replace mmcm6 in the complex that functions during licensing of DNA replication.
messages: Expressed zygotically. Expression begins after the midblastula transition (MBT) at the neurula stage.
messages: Nucleus

8355:LOC108697793
gene id: 8355:LOC108697793
uniprot id: A0A1L8FH34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galanin family.
messages: Secreted

8355:LOC108707764
gene id: 8355:LOC108707764
uniprot id: A0A8J0UBV7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

8355:acod1.S
gene id: 8355:acod1.S
uniprot id: A0A1L8H9G8
names: Similarity
messages: Belongs to the PrpD family.

8355:LOC108712257
gene id: 8355:LOC108712257
uniprot id: A0A8J1MT61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WASH1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Recycling endosome membrane

8355:tmem230.L
gene id: 8355:tmem230.L
uniprot id: A0A974HTW9
uniprot id: Q6GM26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Early endosome
messages: Endosome
messages: Involved in trafficking and recycling of synaptic vesicles.
messages: Late endosome
messages: Membrane
messages: Recycling endosome
messages: autophagosome
messages: synaptic vesicle
messages: trans-Golgi network

8355:tmcc1.L
gene id: 8355:tmcc1.L
uniprot id: A0A1L8GPR0
uniprot id: A0A8J0UT05
uniprot id: A0A8J0UYX7
uniprot id: A0A8J0UZ62
uniprot id: A0A8J0UZ66
uniprot id: A0A8J0V2V0
uniprot id: A0A974D7M4
uniprot id: Q6NRH6
names: Similarity
messages: Belongs to the TEX28 family.

8355:irf8.S
gene id: 8355:irf8.S
uniprot id: A0A1L8GEX1
uniprot id: A0A8J1KK69
uniprot id: A0A8J1KLK6
uniprot id: A0A974CYM8
names: Subcellular Location Annotation
messages: Nucleus

8355:naa38.L
gene id: 8355:naa38.L
uniprot id: A0A974DFH7
uniprot id: Q6GQ67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of naa35, naa38 and naa30.
messages: Cytoplasm

8355:LOC108711286
gene id: 8355:LOC108711286
uniprot id: A0A1L8GZY2
uniprot id: A0A8J0URS7
uniprot id: A0A974DC65
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC100036976
gene id: 8355:LOC100036976
uniprot id: A1L2X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

8355:fgf5.S
gene id: 8355:fgf5.S
uniprot id: A0A1L8HN19
uniprot id: A0A974DU13
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

8355:sia2.S
gene id: 8355:sia2.S
uniprot id: B7ZS16
uniprot id: O57440
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC121399765
gene id: 8355:LOC121399765
uniprot id: A0A8J1M7G8
names: Subcellular Location Annotation
messages: Membrane

8355:LOC121401657
gene id: 8355:LOC121401657
uniprot id: A0A8J1MPB8
names: Similarity
messages: Belongs to the NXPE family.

8355:btd.L
gene id: 8355:btd.L
uniprot id: A0A1L8FW84
uniprot id: A0A974CLT1
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

8355:pard3.S
gene id: 8355:pard3.S
uniprot id: A0A1L8FQM3
uniprot id: A0A8J0VIV2
uniprot id: A0A8J0VL31
uniprot id: A0A8J0VLB3
uniprot id: A0A8J0VLB8
uniprot id: A0A8J0VM86
uniprot id: A0A8J0VPU9
uniprot id: A0A8J0VPV1
uniprot id: A0A974CJP9
uniprot id: Q6GN19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR3 family.
messages: Cell junction
messages: Endomembrane system

8355:LOC121396193
gene id: 8355:LOC121396193
uniprot id: A0A8J1LDQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted

8355:crygdl.33.L
gene id: 8355:crygdl.33.L
uniprot id: A0A8J0TCC5
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:mef2a.L
gene id: 8355:mef2a.L
uniprot id: Q03414
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MEF2 family.
messages: Expressed both maternally and zygotically. Zygotic expression begins after the neurula stage.
messages: Interacts with hdac9 and nlk2.
messages: May regulate muscle-specific transcription in the embryo and may regulate transcription of a variety of cell types in the adult. Binds to the sequence 5'-CTA[TA]4TAR-3'. Acts downstream of nlk2 in anterior neural development, including eye formation.
messages: Nucleus
messages: Restricted to the somitic mesoderm of early embryos. Expressed in the head region of neurula stage embryos and in body muscle (myotomes) of the tadpole. Expressed in all tissues examined in the adult.

8355:pyroxd1.L
gene id: 8355:pyroxd1.L
uniprot id: A0A1L8GVW1
uniprot id: A0A974D9M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.
messages: sarcomere

8355:XB5835883.S
gene id: 8355:XB5835883.S
uniprot id: A0A1L8FS70
uniprot id: A0A8J1L239
uniprot id: A0A974CJ98
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

8355:LOC108700822
gene id: 8355:LOC108700822
uniprot id: A0A1L8ES49
uniprot id: A0A8J1LUT8
uniprot id: A0A974BWB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:tpk1.L
gene id: 8355:tpk1.L
uniprot id: A0A1L8FWN4
uniprot id: A0A974CPF7
names: Similarity
messages: Belongs to the thiamine pyrophosphokinase family.

8355:prcp.S
gene id: 8355:prcp.S
uniprot id: A0A1L8HBB0
uniprot id: A0A974HXA8
names: Similarity
messages: Belongs to the peptidase S28 family.

8355:nkap.L
gene id: 8355:nkap.L
uniprot id: A0A1L8F7L9
uniprot id: A0A974H7C6
names: Similarity
messages: Belongs to the NKAP family.

8355:cdc42ep3.S
gene id: 8355:cdc42ep3.S
uniprot id: A0A1L8G1Z5
uniprot id: A0A974CQM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

8355:qpct.L
gene id: 8355:qpct.L
uniprot id: A0A974CWH4
uniprot id: Q66KH1
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

8355:hsp30c.L
gene id: 8355:hsp30c.L
uniprot id: P30218
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

8355:LOC108709056
gene id: 8355:LOC108709056
uniprot id: A0A8J0ULQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:krt56.L
gene id: 8355:krt56.L
uniprot id: A0A1L8ERY0
names: Similarity
messages: Belongs to the intermediate filament family.

8355:trub2.L
gene id: 8355:trub2.L
uniprot id: A0A1L8F5S6
uniprot id: A0A8J1LEB3
uniprot id: A0A974C5L9
uniprot id: A1L2U6
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

8355:krt19.L
gene id: 8355:krt19.L
uniprot id: A0A8J0TRW3
uniprot id: Q6IRP5
names: Similarity
messages: Belongs to the intermediate filament family.

8355:phaf1.S
gene id: 8355:phaf1.S
uniprot id: A0A1L8GEE4
uniprot id: A0A974HLP8
names: Similarity
messages: Belongs to the PHAF1 family.

8355:ppox.L
gene id: 8355:ppox.L
uniprot id: A0A1L8FD07
uniprot id: A0A974CAD8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
messages: Mitochondrion inner membrane

8355:b4galt1l.L
gene id: 8355:b4galt1l.L
uniprot id: A0A1L8HWV1
uniprot id: A0A974DZ46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

8355:LOC108714962
gene id: 8355:LOC108714962
uniprot id: A0A8J1N063
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

8355:dag1.S
gene id: 8355:dag1.S
uniprot id: A0A1L8GH99
uniprot id: A0A974D2N2
uniprot id: Q7ZX16
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.
messages: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
messages: cytoskeleton
messages: extracellular space
messages: nucleoplasm
messages: sarcolemma

8355:xirp1.L
gene id: 8355:xirp1.L
uniprot id: A0A1L8FV54
uniprot id: A0A8J1KWM0
uniprot id: A0A8J1KWM7
uniprot id: A0A974HF04
names: Domain
names: Similarity
messages: Belongs to the Xin family.
messages: Xin repeats bind F-actin.

8355:gpx2.L
gene id: 8355:gpx2.L
uniprot id: A0A8J0QGF7
names: Similarity
messages: Belongs to the glutathione peroxidase family.

8355:ngly1.L
gene id: 8355:ngly1.L
uniprot id: A0A1L8FWC2
uniprot id: A0A974HFE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglutaminase-like superfamily. PNGase family.
messages: Cytoplasm
messages: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.

8355:adra1a.L
gene id: 8355:adra1a.L
uniprot id: A0A1L8H1B6
uniprot id: A0A974HTV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: caveola

8355:dpf1.S
gene id: 8355:dpf1.S
uniprot id: A0A1L8F3T8
uniprot id: A0A8J0THH1
uniprot id: A0A974C3U9
names: Similarity
messages: Belongs to the requiem/DPF family.

8355:LOC108710155
gene id: 8355:LOC108710155
uniprot id: A0A1L8H315
uniprot id: A0A8J0US36
uniprot id: A0A8J1MN02
uniprot id: A0A974DG03
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8355:tmem198.S
gene id: 8355:tmem198.S
uniprot id: A0A1L8H9P4
uniprot id: A0A1L8H9U0
uniprot id: A0A974HWD9
uniprot id: A0A974HWL0
uniprot id: Q66IY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

8355:il10rb.L
gene id: 8355:il10rb.L
uniprot id: A0A1L8HCL7
uniprot id: A0A974DKU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.

8355:LOC108707602
gene id: 8355:LOC108707602
uniprot id: A0A8J1M7F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:armt1.L
gene id: 8355:armt1.L
uniprot id: A0A974DAD7
uniprot id: Q6AXB1
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
messages: Automethylated.
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Human C6orf211 has been reportedly associated with a protein carboxyl methyltransferase activity, but whether this protein indeed has such an activity remains to be determined (By similarity). It has been later shown to belong to a family of metal-dependent phosphatases implicated in metabolite damage-control (By similarity).
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (By similarity). Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (By similarity). Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues (By similarity). Possibly methylates PCNA, suggesting it is involved in the DNA damage response (By similarity).
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

8355:LOC108718670
gene id: 8355:LOC108718670
uniprot id: A0A8J1KWJ3
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:fnip1.L
gene id: 8355:fnip1.L
uniprot id: A0A8J1MK45
uniprot id: A0A8J1ML24
uniprot id: A0A8J1MM33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

8355:pdcd10.S
gene id: 8355:pdcd10.S
uniprot id: A0A974CU10
uniprot id: Q8AVR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDCD10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development.

8355:polr3gl.L
gene id: 8355:polr3gl.L
uniprot id: A0A1L8FBW2
uniprot id: A0A974C9K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Nucleus

8355:fis1.S
gene id: 8355:fis1.S
uniprot id: A0A8J1MSV1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.
messages: Membrane
messages: Mitochondrion outer membrane
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

8355:dlk2.S
gene id: 8355:dlk2.S
uniprot id: A0A1L8G115
uniprot id: A0A8J0VJU2
uniprot id: A0A974CPV1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:taf2.S
gene id: 8355:taf2.S
uniprot id: A0A8J0SYA8
uniprot id: A0A8J0T7F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF2 family.
messages: Nucleus

8355:LOC108710666
gene id: 8355:LOC108710666
uniprot id: A0A1L8H456
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:adck2.S
gene id: 8355:adck2.S
uniprot id: A0A1L8GQI7
uniprot id: A0A974D8I2
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

8355:LOC121399356
gene id: 8355:LOC121399356
uniprot id: A0A1L8HMY4
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

8355:fabp6.S
gene id: 8355:fabp6.S
uniprot id: A0A1L8GQZ7
uniprot id: A0A974D8V2
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

8355:chpf2.S
gene id: 8355:chpf2.S
uniprot id: A0A1L8FQ07
uniprot id: A0A974CJY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

8355:osgep.L
gene id: 8355:osgep.L
uniprot id: Q7SYR1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Component of the EKC/KEOPS complex composed of at least tp53rk, tprkb, osgep and lage3; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Osgep likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
messages: Cytoplasm
messages: Nucleus

8355:mvb12b.S
gene id: 8355:mvb12b.S
uniprot id: A0A1L8F1T9
uniprot id: A0A8J0TGI0
uniprot id: A0A8J0TQ58
uniprot id: A0A8J0TR74
uniprot id: A0A974H5F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MVB12 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

8355:dlat.L
gene id: 8355:dlat.L
uniprot id: A0A974CFW0
uniprot id: A0AUS4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Mitochondrion
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

8355:ptn.S
gene id: 8355:ptn.S
uniprot id: P48533
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the pleiotrophin family.
messages: Expressed in high levels in brain and eye. Lower levels in bone. In the tailbud embryo stage, it is expressed exclusively in the central nervous system, especially in the hind region of the brain.
messages: Secreted
messages: Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (By similarity). Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups (By similarity). Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration (By similarity). Has antibacterial activity against both Gram-positive and Gram-negative bacteria (PubMed:20308059).

8355:qrfp.S
gene id: 8355:qrfp.S
uniprot id: A0A1L8F1K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFamide neuropeptide family.
messages: Secreted

8355:itga4.S
gene id: 8355:itga4.S
uniprot id: Q91687
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the integrin alpha chain family.
messages: Fibronectin and V-CAM adhesion receptor.
messages: Heterodimer of an alpha and a beta subunit.
messages: Membrane

8355:gk5.L
gene id: 8355:gk5.L
uniprot id: A0A1L8GB58
uniprot id: A0A8J1KLC8
uniprot id: A0A974CX73
uniprot id: Q6GP95
names: Similarity
messages: Belongs to the FGGY kinase family.

8355:riox1.L
gene id: 8355:riox1.L
uniprot id: A0A1L8G801
uniprot id: A0A974HJK2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ROX family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Nucleus
messages: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.

8355:uchl3.S
gene id: 8355:uchl3.S
uniprot id: A0A1L8H960
uniprot id: A0A974DIJ6
names: Similarity
messages: Belongs to the peptidase C12 family.

8355:LOC108712711
gene id: 8355:LOC108712711
uniprot id: A0A1L8GRR8
uniprot id: A0A8J1MRG8
uniprot id: A0A974D9A7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

8355:dnaaf10.L
gene id: 8355:dnaaf10.L
uniprot id: Q5M7F6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Dynein axonemal particle
messages: Interacts with PIH1D1; the interaction associates DNAAF10 with the R2TP complex (By similarity). Interacts with several dynein axonemal assembly factors (By similarity).
messages: Key assembly factor specifically required for the stability of axonemal dynein heavy chains in cytoplasm.

8355:man1b1.L
gene id: 8355:man1b1.L
uniprot id: Q68FC2
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

8355:LOC108715042
gene id: 8355:LOC108715042
uniprot id: A0A8J1KK30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

8355:mmp11.L
gene id: 8355:mmp11.L
uniprot id: A0A8J0V754
uniprot id: Q11005
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase M10A family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: Expressed in fibroblast cells that are activated by thyroid hormone. High levels in resorbing tail.
messages: May be involved in the modification of the extracellular matrix during metamorphic apoptosis.
messages: extracellular matrix

8355:actc1.S
gene id: 8355:actc1.S
uniprot id: A0A1L8EZH4
uniprot id: A0A974H4Q3
names: Similarity
messages: Belongs to the actin family.

8355:grik2.L
gene id: 8355:grik2.L
uniprot id: A0A1L8G8Y6
uniprot id: B9V8S1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8355:aldh6a1.S
gene id: 8355:aldh6a1.S
uniprot id: A0A1L8F0L7
uniprot id: A0A8J0TM88
uniprot id: A0A8J1LMS1
uniprot id: A0A974C2C5
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

8355:impact.L
gene id: 8355:impact.L
uniprot id: Q9W625
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the IMPACT family.
messages: Cytoplasm
messages: In contrast to the mouse or rabbit ortholog, the IMPACT locus is not imprinted in Xenopus.
messages: Interacts with GCN1; prevents the interaction of GCN1 with EIF2AK4/GCN2 and inhibits EIF2AK4/GCN2 kinase activity. Interaction with RPL39; this interaction occurs in a GCN1-independent manner. Associates with ribosomes; this interaction occurs in a GCN1-independent manner. Associates with actin; this interaction occurs in a GCN1-independent manner.
messages: Present in oocytes as well as in early embryos.
messages: Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. Plays a role in differentiation of neuronal cells by stimulating neurite outgrowth.
messages: Ubiquitous both in embryo and adult.

8355:tspan2.L
gene id: 8355:tspan2.L
uniprot id: A0A1L8HDZ1
uniprot id: A0A974DPI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8355:cops3.L
gene id: 8355:cops3.L
uniprot id: Q7ZTN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN3 family.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity).
messages: Component of the CSN complex, probably composed of cops1, cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
messages: Cytoplasm
messages: Nucleus

8355:rho.S
gene id: 8355:rho.S
uniprot id: A0A1L8GHL0
uniprot id: A0A974D0F1
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Contains one covalently linked retinal chromophore.
messages: Membrane
messages: photoreceptor outer segment

8355:slc26a4.2.S
gene id: 8355:slc26a4.2.S
uniprot id: A0A8J1MRP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sodium-independent transporter of chloride and iodide.

8355:LOC108702425
gene id: 8355:LOC108702425
uniprot id: A0A1L8EQD7
uniprot id: A0A974H1K7
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC121396273
gene id: 8355:LOC121396273
uniprot id: A0A8J1LEC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferlin family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

8355:h2aj.S
gene id: 8355:h2aj.S
uniprot id: A0A974HQ53
uniprot id: Q6INC9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:LOC121401255
gene id: 8355:LOC121401255
uniprot id: A0A8J1MIG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:dot1l.L
gene id: 8355:dot1l.L
uniprot id: A0A1L8HWP3
uniprot id: A0A8J1KL27
uniprot id: A0A974I3G2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
messages: Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
messages: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
messages: Nucleus

8355:patl1.L
gene id: 8355:patl1.L
uniprot id: Q32N92
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PAT1 family.
messages: Interacts with ribonucleoprotein complex components.
messages: Nucleus
messages: Nucleus speckle
messages: Only starts to be expressed in late oogenesis (stage IV) and is relatively abundant in eggs and embryos, peaking at embryonic stages 12-20, corresponding to gastrula and neural fold stages. At stage 42, which corresponds to the tadpole-like stage, present in neuron-rich tissues such as eye and brain (at protein level).
messages: P-body
messages: PML body
messages: RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly (By similarity). When tethered to a reporter mRNA, able to repress translation (PubMed:20826699).

8355:lsm3.S
gene id: 8355:lsm3.S
uniprot id: A0A974D0G0
uniprot id: A3KMU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

8355:vps52.L
gene id: 8355:vps52.L
uniprot id: A0A1L8F8B3
uniprot id: A0A974H7V7
names: Similarity
messages: Belongs to the VPS52 family.

8355:tmem50a.L
gene id: 8355:tmem50a.L
uniprot id: A0A8J0UF66
uniprot id: A0A974DNF6
uniprot id: Q3KQD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

8355:c1orf52.S
gene id: 8355:c1orf52.S
uniprot id: Q5FWN9
names: Similarity
messages: Belongs to the UPF0690 family.

8355:lgalsl.L
gene id: 8355:lgalsl.L
uniprot id: Q6DDR8
names: Caution
names: Function
messages: Does not bind lactose, and may not bind carbohydrates.
messages: Most of the residues in the galectin domain that have been shown to be critical for carbohydrate-binding in other galectins are not conserved.

8355:orc1.L
gene id: 8355:orc1.L
uniprot id: P70049
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC1 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Nucleus
messages: ORC is composed of six subunits.

8355:LOC108702761
gene id: 8355:LOC108702761
uniprot id: A0A1L8EMN4
uniprot id: A0A974BU24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: cytoskeleton

8355:LOC108714147
gene id: 8355:LOC108714147
uniprot id: A0A1L8GLE8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108697167
gene id: 8355:LOC108697167
uniprot id: A0A1L8FE08
uniprot id: A0A974CBC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:naaa.L
gene id: 8355:naaa.L
uniprot id: A0A8J0U990
uniprot id: A0A8J1M6K9
uniprot id: A0A974DXS5
uniprot id: Q66KI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid ceramidase family.
messages: Lysosome

8355:LOC121394487
gene id: 8355:LOC121394487
uniprot id: A0A8J1KWA3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:LOC108706566
gene id: 8355:LOC108706566
uniprot id: A0A8J1MKD4
names: Similarity
messages: Belongs to the helicase family.

8355:imp3.S
gene id: 8355:imp3.S
uniprot id: A0A1L8GGY4
uniprot id: A0A974HMH1
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

8355:txlng.L
gene id: 8355:txlng.L
uniprot id: A0A8J0UFK2
names: Similarity
messages: Belongs to the taxilin family.

8355:micos10.S
gene id: 8355:micos10.S
uniprot id: Q4V7L6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

8355:tbccd1.L
gene id: 8355:tbccd1.L
uniprot id: A0A974BZR3
uniprot id: Q08AV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCC family.
messages: May play a role in the regulation of centrosome and Golgi apparatus positioning.
messages: centrosome
messages: spindle pole

8355:mal.L
gene id: 8355:mal.L
uniprot id: A0A974CWK2
uniprot id: Q6PBB5
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108699090
gene id: 8355:LOC108699090
uniprot id: A0A1L8FC22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:abhd1.L
gene id: 8355:abhd1.L
uniprot id: A0A1L8GCI3
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

8355:LOC108702581
gene id: 8355:LOC108702581
uniprot id: A0A1L8ELB7
uniprot id: A0A974BT27
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

8355:hebp2.L
gene id: 8355:hebp2.L
uniprot id: A0A1L8G7J6
uniprot id: A0A974CVY6
names: Similarity
messages: Belongs to the HEBP family.

8355:cox5a.S
gene id: 8355:cox5a.S
uniprot id: Q6IP26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

8355:casc3.S
gene id: 8355:casc3.S
uniprot id: A0A1L8EKQ0
uniprot id: A0A8J1LVW0
uniprot id: A0A8J1LW96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASC3 family.
messages: Nucleus speckle
messages: dendrite
messages: perinuclear region

8355:LOC108696960
gene id: 8355:LOC108696960
uniprot id: A0A8J0T464
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8355:nlk.2.L
gene id: 8355:nlk.2.L
uniprot id: A0A8J1LTL4
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

8355:prfprl2.1.L
gene id: 8355:prfprl2.1.L
uniprot id: A0A8J1MPB6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:prdm2.L
gene id: 8355:prdm2.L
uniprot id: A0A1L8FMC8
uniprot id: A0A8J1L6Y1
uniprot id: A0A974HCB2
names: Subcellular Location Annotation
messages: Nucleus

8355:neu3.1.S
gene id: 8355:neu3.1.S
uniprot id: A0A8J1MHM1
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

8355:LOC108701950
gene id: 8355:LOC108701950
uniprot id: A0A1L8EZD7
uniprot id: A0A974H4L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:ogfr.S
gene id: 8355:ogfr.S
uniprot id: A0A8J0TYA6
names: Similarity
messages: Belongs to the opioid growth factor receptor family.

8355:tbx4.S
gene id: 8355:tbx4.S
uniprot id: A0A1L8H810
uniprot id: A0A974DI30
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8355:lipc.S
gene id: 8355:lipc.S
uniprot id: A0A1L8GT68
uniprot id: A0A974HR85
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:LOC121401320
gene id: 8355:LOC121401320
uniprot id: A0A8J1MKS7
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108711794
gene id: 8355:LOC108711794
uniprot id: A0A8J0UX47
names: Similarity
messages: Belongs to the phospholipid scramblase family.

8355:hnf1a.L
gene id: 8355:hnf1a.L
uniprot id: A0A1L8I0A9
uniprot id: A0A974I568
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HNF1 homeobox family.
messages: Nucleus

8355:mrps11.L
gene id: 8355:mrps11.L
uniprot id: A0A1L8H0X4
uniprot id: A0A8J1MID2
uniprot id: A0A974HTH6
uniprot id: Q5PQ33
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

8355:LOC108699074
gene id: 8355:LOC108699074
uniprot id: A0A8J0TLG5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:nkx1-2.L
gene id: 8355:nkx1-2.L
uniprot id: Q7SZI6
names: Subcellular Location Annotation
messages: Nucleus

8355:odc1.S
gene id: 8355:odc1.S
uniprot id: A0A1L8G533
uniprot id: A0A974CTA4
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

8355:LOC100653495
gene id: 8355:LOC100653495
uniprot id: A0A8J0U7X2
uniprot id: E3URQ0
names: Subcellular Location Annotation
messages: Chromosome

8355:LOC108695630
gene id: 8355:LOC108695630
uniprot id: A0A1L8HZE6
uniprot id: A0A974I4C8
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108704007
gene id: 8355:LOC108704007
uniprot id: A0A8J1MYR1
uniprot id: A0A8J1MZL5
names: Subcellular Location Annotation
messages: Cytoplasm

8355:gpam.S
gene id: 8355:gpam.S
uniprot id: A0A8J1L9K3
uniprot id: A0A8J1L9K5
uniprot id: A1A5I8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.
messages: Mitochondrion outer membrane

8355:LOC108704986
gene id: 8355:LOC108704986
uniprot id: A0A8J1M6F6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC121396601
gene id: 8355:LOC121396601
uniprot id: A0A8J1LDJ8
uniprot id: A0A8J1LDM2
uniprot id: A0A8J1LF41
names: Similarity
messages: Belongs to the AAA ATPase family.

8355:trpm6.L
gene id: 8355:trpm6.L
uniprot id: A0A1L8HYE9
uniprot id: A0A8J1KTX9
uniprot id: A0A974DZM4
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
messages: Membrane

8355:LOC121393963
gene id: 8355:LOC121393963
uniprot id: A0A8J1KU50
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108706080
gene id: 8355:LOC108706080
uniprot id: A0A8J1M7H8
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108709504
gene id: 8355:LOC108709504
uniprot id: A0A1L8H775
uniprot id: A0A974HVI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8355:c5orf24.L
gene id: 8355:c5orf24.L
uniprot id: A0A1L8GWW4
uniprot id: A0A8J1MKS4
uniprot id: A0A974HS66
names: Similarity
messages: Belongs to the UPF0461 family.

8355:LOC108718050
gene id: 8355:LOC108718050
uniprot id: A0A1L8G3U5
uniprot id: A0A974CRX7
names: Similarity
messages: Belongs to the leprecan family.

8355:LOC108701733
gene id: 8355:LOC108701733
uniprot id: A0A1L8EZ68
uniprot id: A0A8J1LTN1
uniprot id: A0A8J1LVC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8355:LOC108701447
gene id: 8355:LOC108701447
uniprot id: A0A1L8EWW1
uniprot id: A0A974C020
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

8355:LOC108713841
gene id: 8355:LOC108713841
uniprot id: A0A1L8GJA1
uniprot id: A0A8J1MX42
uniprot id: A0A974D1H5
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.

8355:LOC121397320
gene id: 8355:LOC121397320
uniprot id: A0A8J1LJX8
names: Subcellular Location Annotation
messages: Membrane

8355:tgm3l.6.L
gene id: 8355:tgm3l.6.L
uniprot id: A0A8J0TL47
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

8355:calm2.S
gene id: 8355:calm2.S
uniprot id: P0DP33
uniprot id: P0DP34
uniprot id: P0DP35
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the calmodulin family.
messages: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases.
messages: This protein has four functional calcium-binding sites.

8355:ltb4r.L
gene id: 8355:ltb4r.L
uniprot id: A0A8J1KVU0
uniprot id: A0A8J1KYU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

8355:npepl1.L
gene id: 8355:npepl1.L
uniprot id: Q05AX8
names: Similarity
messages: Belongs to the peptidase M17 family.

8355:cox7b.S
gene id: 8355:cox7b.S
uniprot id: A0A1L8F2E7
uniprot id: A0A974H651
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Membrane
messages: Mitochondrion inner membrane

8355:prkcz.S
gene id: 8355:prkcz.S
uniprot id: A0A1L8FG56
uniprot id: A0A8J0TEN8
uniprot id: A0A8J1LCV3
uniprot id: A0A8J1LD22
uniprot id: A0A974CC60
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

8355:mrpl27.L
gene id: 8355:mrpl27.L
uniprot id: A0A8J0TTX1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

8355:LOC121396496
gene id: 8355:LOC121396496
uniprot id: A0A8J1LCT7
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:exosc2.S
gene id: 8355:exosc2.S
uniprot id: A0A8J0TET8
uniprot id: Q6GPU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP4 family.
messages: Cytoplasm

8355:ubr3.L
gene id: 8355:ubr3.L
uniprot id: A0A8J1LU64
uniprot id: A0A8J1LU71
uniprot id: A0A8J1LUS2
uniprot id: A0A8J1LVL8
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

8355:gpat4.S
gene id: 8355:gpat4.S
uniprot id: A0A1L8GRR1
uniprot id: A0A8J0UV10
uniprot id: A0A974HQT1
uniprot id: Q0IHE9
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

8355:LOC121395620
gene id: 8355:LOC121395620
uniprot id: A0A1L8FN82
uniprot id: A0A8J1LA46
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

8355:LOC108708721
gene id: 8355:LOC108708721
uniprot id: A0A1L8HJ43
uniprot id: A0A974DSL3
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

8355:rrs1.S
gene id: 8355:rrs1.S
uniprot id: Q5XGX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

8355:LOC121398084
gene id: 8355:LOC121398084
uniprot id: A0A8J1LTD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:krt17.L
gene id: 8355:krt17.L
uniprot id: Q5XGU0
names: Similarity
messages: Belongs to the intermediate filament family.

8355:stx6.L
gene id: 8355:stx6.L
uniprot id: Q6IP43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

8355:LOC108714333
gene id: 8355:LOC108714333
uniprot id: A0A1L8GMH8
uniprot id: A0A974D6L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

8355:LOC108702317
gene id: 8355:LOC108702317
uniprot id: A0A8J1M1B0
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with NCDN.
messages: Membrane

8355:kmt5a.S
gene id: 8355:kmt5a.S
uniprot id: A0A8J0TPU6
uniprot id: A0A974DV13
uniprot id: Q08AY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.
messages: Chromosome
messages: Nucleus
messages: Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis.

8355:LOC108717066
gene id: 8355:LOC108717066
uniprot id: A0A1L8GAX8
uniprot id: A0A8J1KPS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

8355:astl3a.1.L
gene id: 8355:astl3a.1.L
uniprot id: A0A8J1LEL8
uniprot id: B7ZQ15
uniprot id: P42664
names: Caution
names: Cofactor
names: Developmental Stage
messages: Binds 1 zinc ion per subunit.
messages: Exclusively in the anterior neural fold of neurula stage embryos. By the tailbud stage, the protein is localized in specialized cephalic ectoderm, in a region probably corresponding to the hatching gland.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:tceanc2.S
gene id: 8355:tceanc2.S
uniprot id: Q6GM10
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108705887
gene id: 8355:LOC108705887
uniprot id: A0A8J1MJ70
names: Similarity
messages: Belongs to the WD repeat WDR91 family.

8355:wnt9a.L
gene id: 8355:wnt9a.L
uniprot id: A0A8J0VJI7
uniprot id: A0A8J0VNB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8355:fgf1.L
gene id: 8355:fgf1.L
uniprot id: A0A1L8GXF9
uniprot id: A0A974DDE8
uniprot id: Q6GLR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: Nucleus
messages: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.
messages: Secreted
messages: cell cortex
messages: cytosol

8355:LOC108702284
gene id: 8355:LOC108702284
uniprot id: A0A1L8EPM4
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

8355:nsun3.L
gene id: 8355:nsun3.L
uniprot id: A0A8J1M750
uniprot id: A0A8J1M752
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108699035
gene id: 8355:LOC108699035
uniprot id: A0A8J0TCT2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108704465
gene id: 8355:LOC108704465
uniprot id: A0A8J1LJL1
names: Similarity
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.

8355:cystm1.S
gene id: 8355:cystm1.S
uniprot id: A0A974HRX2
uniprot id: Q3KQ95
names: Similarity
messages: Belongs to the CYSTM1 family.

8355:lrp2.L
gene id: 8355:lrp2.L
uniprot id: A0A1L8EWA8
uniprot id: A0A8J0TMK5
uniprot id: A0A8J0TV20
uniprot id: A0A8J1LWI3
names: Caution
names: Similarity
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:arg2.S
gene id: 8355:arg2.S
uniprot id: Q91554
names: Cofactor
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subunit
names: Tissue Specificity
messages: As well as its role in the urea cycle, may be involved in tissue remodeling.
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.
messages: By thyroid hormone (T3).
messages: Expressed at differing tadpole stages in tail, intestine, hindlimb and trunk region. Strongest in tadpole tail.
messages: First detected in neurula (stage 16/17). Highest levels in whole tadpole found around stage 47/48. In the intestine, increased levels are found during metamorphosis (stages 58-64) and in the hindlimb, expressed at low levels during metamorphosis until stage 66 when levels dramatically increase. In the tail, a constant high level of expression is found throughout metamorphosis.
messages: Homotrimer.

8355:LOC108714919
gene id: 8355:LOC108714919
uniprot id: A0A8J1KKJ5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108695872
gene id: 8355:LOC108695872
uniprot id: A0A8J1L607
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:ltb.L
gene id: 8355:ltb.L
uniprot id: A0A1L8F8I5
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8355:LOC121395393
gene id: 8355:LOC121395393
uniprot id: A0A1L8FJT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

8355:yipf2.S
gene id: 8355:yipf2.S
uniprot id: A0A8J1MPA1
uniprot id: Q5XH44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

8355:wdr82.L
gene id: 8355:wdr82.L
uniprot id: A0A974HPZ4
uniprot id: Q640J6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SWD2 family.
messages: Chromosome
messages: Component of the SET1 complex.
messages: Nucleus
messages: Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs).

8355:LOC121400001
gene id: 8355:LOC121400001
uniprot id: A0A8J1M935
names: Subcellular Location Annotation
messages: Nucleus

8355:pik3cg.S
gene id: 8355:pik3cg.S
uniprot id: A0A1L8GTX9
uniprot id: A0A8J0UR14
uniprot id: A0A974HRH2
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

8355:rps13.S
gene id: 8355:rps13.S
uniprot id: A0A974CYF7
uniprot id: P49393
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Component of the small ribosomal subunit.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

8355:prdm15.S
gene id: 8355:prdm15.S
uniprot id: A0A1L8H5F4
uniprot id: A0A8J0UBE5
uniprot id: A0A8J0UI35
uniprot id: A0A8J0UJD0
uniprot id: A0A8J0UJG1
uniprot id: A0A8J0UM82
uniprot id: A0A8J0UM87
uniprot id: A0A8J1MCD3
uniprot id: A0A974HV82
names: Subcellular Location Annotation
messages: Nucleus

8355:acvr1c.S
gene id: 8355:acvr1c.S
uniprot id: A0A1L8EP06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

8355:LOC108703507
gene id: 8355:LOC108703507
uniprot id: A0A8J0U1Z4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:LOC108716523
gene id: 8355:LOC108716523
uniprot id: A0A8J1KMH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

8355:st6gal1.S
gene id: 8355:st6gal1.S
uniprot id: A0A1L8G4R6
uniprot id: A0A8J1KUD7
uniprot id: A0A974CSL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8355:LOC108710022
gene id: 8355:LOC108710022
uniprot id: A0A1L8HB42
uniprot id: A0A8J0UQC3
uniprot id: A0A8J1MFN1
uniprot id: A0A8J1MGL0
uniprot id: A0A8J1MHG7
uniprot id: A0A974DM48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

8355:tll2l.L
gene id: 8355:tll2l.L
uniprot id: B1H1V3
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:vangl2.S
gene id: 8355:vangl2.S
uniprot id: A0A974C4Y9
uniprot id: Q90Z05
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Vang family.
messages: Cell membrane
messages: During gastrulation, broadly expressed in the dorsal region in both mesodermal and neural tissues. From the neurula stages, expressed throughout the neural tube. In tailbud stages, expression declines in the anterior notochord but remains strong in the posterior notochord and in the neural tube. Also weakly expressed in the prenephritic region of late tailbud embryos.
messages: Expressed both maternally and zygotically throughout early development. Maternal expression declines gradually by the early gastrula stage (stage 10). Zygotic expression increases by late gastrula stage (stage 12) with strong expression from the midneurula stage (stage 15) onward.
messages: Has a role in non-canonical Wnt/planar cell polarity (PCP) signaling; can recruit dvl/dsh and prickle from the cytoplasm to the plasma membrane. Acts in a PCP complex to regulate the polarized assembly of fibronectrin on the surface of the mesoderm during gastrulation. Regulates convergent extension in both dorsal mesoderm and neural tissue without affecting cell fate. Regulates neural fold closure during neurulation (PubMed:12074560, PubMed:15854914). May be required for cell surface localization of fzd3 and fzd6 in the inner ear (By similarity).
messages: Interacts with dvl/dsh (By similarity). Interacts with prickle3 (PubMed:27658614, PubMed:26079437).
messages: Membrane

8355:grin2a.L
gene id: 8355:grin2a.L
uniprot id: B7ZSK1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A hydrophobic region that gives rise to the prediction of a transmembrane span does not cross the membrane, but is part of a discontinuously helical region that dips into the membrane and is probably part of the pore and of the selectivity filter.
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:28232581). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in dendritic branching in brain neurons and in synaptic plasticity (PubMed:18216193).
messages: Contains an N-terminal domain, a ligand-binding domain and a transmembrane domain. Agonist binding to the extracellular ligand-binding domains triggers channel gating.
messages: Heterotetramer. Forms heterotetrameric channels composed of two zeta subunits (grin1), and two epsilon subunits (grin2a, grin2b, grin2c or grin2d) (in vitro) (PubMed:28232581). In vivo, the subunit composition may depend on the expression levels of the different subunits (Probable).
messages: Postsynaptic cell membrane

8355:LOC108715013
gene id: 8355:LOC108715013
uniprot id: A0A8J1KJP4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:LOC108695708
gene id: 8355:LOC108695708
uniprot id: A0A1L8FIC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8355:piwil2.L
gene id: 8355:piwil2.L
uniprot id: A0A1L8H225
uniprot id: A0A974DET2
names: Similarity
messages: Belongs to the argonaute family.

8355:arf5.S
gene id: 8355:arf5.S
uniprot id: A0A1L8FQF3
uniprot id: A0A974HDC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

8355:mtx3.L
gene id: 8355:mtx3.L
uniprot id: A0A8J1LYP2
uniprot id: Q3KPT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metaxin family.
messages: Could function in transport of proteins into the mitochondrion.
messages: Membrane
messages: Mitochondrion
messages: Mitochondrion outer membrane
messages: Part of a large protein complex spanning both mitochondrial membranes termed the mitochondrial intermembrane space bridging (MIB) complex.

8355:prkcd.S
gene id: 8355:prkcd.S
uniprot id: A0A8J1MZ98
uniprot id: Q6DCJ8
uniprot id: Q7SZH8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression.
messages: Cytoplasm
messages: Interacts with PDPK1 (via N-terminal region), RAD9A, CDCP1, MUC1 and VASP.
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.
messages: Nucleus
messages: perinuclear region

8355:LOC121399939
gene id: 8355:LOC121399939
uniprot id: A0A8J1M839
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:nfasc.S
gene id: 8355:nfasc.S
uniprot id: A0A1L8H6R9
uniprot id: A0A8J0UK36
uniprot id: A0A8J0UMV6
uniprot id: A0A8J1MDC3
uniprot id: A0A8J1MDC7
uniprot id: A0A8J1MDD2
uniprot id: A0A8J1MDE7
uniprot id: A0A8J1MDF1
uniprot id: A0A8J1MDF4
uniprot id: A0A8J1MDG7
uniprot id: A0A8J1MDV1
uniprot id: A0A8J1MDV9
uniprot id: A0A8J1MDW4
uniprot id: A0A8J1MED9
uniprot id: A0A8J1MEE4
uniprot id: A0A8J1MEF0
uniprot id: A0A8J1MF92
uniprot id: A0A8J1MF97
names: Similarity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

8355:LOC108716937
gene id: 8355:LOC108716937
uniprot id: A0A8J0VBF7
uniprot id: A0A8J1KQW4
names: Similarity
messages: Belongs to the SAPAP family.

8355:stoml1.L
gene id: 8355:stoml1.L
uniprot id: A9ULZ3
names: Similarity
messages: Belongs to the band 7/mec-2 family.

8355:LOC108717508
gene id: 8355:LOC108717508
uniprot id: A0A1L8G5L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8355:man1c1.S
gene id: 8355:man1c1.S
uniprot id: A0A1L8H866
uniprot id: A0A974DJH8
uniprot id: Q6NRH5
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

8355:furin.S
gene id: 8355:furin.S
uniprot id: Q6DE77
names: Similarity
messages: Belongs to the peptidase S8 family.

8355:tekt3.S
gene id: 8355:tekt3.S
uniprot id: Q5M7C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: flagellum

8355:LOC108700447
gene id: 8355:LOC108700447
uniprot id: A0A8J0TQX4
uniprot id: A0A8J1LPE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

8355:tcf19.L
gene id: 8355:tcf19.L
uniprot id: A0A1L8F8I8
uniprot id: A0A974H857
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC121397903
gene id: 8355:LOC121397903
uniprot id: A0A8J1LR62
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:h2az1.L
gene id: 8355:h2az1.L
uniprot id: A0A974DTH2
uniprot id: P70094
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Expression is highest at the gastrula stage. Expressed preferentially in tissues of mesoderm origin, such as the notochord and some regions of the primitive ear.
messages: Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Zl forms a heterodimer with H2B (By similarity).
messages: Ubiquitously expressed.
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be required at gastrulation for correct mesoderm formation.

8355:crygdl.17.L
gene id: 8355:crygdl.17.L
uniprot id: A0A1L8HWW0
uniprot id: A0A974I3S1
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:yipf6.L
gene id: 8355:yipf6.L
uniprot id: A2RV54
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:syvn1.S
gene id: 8355:syvn1.S
uniprot id: Q5XHH7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HRD1 family.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Sequesters p53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (By similarity).
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: The RING-type zinc finger is required for E3 ligase activity.

8355:ahdc1.L
gene id: 8355:ahdc1.L
uniprot id: A0A8J0UEI8
names: Subcellular Location Annotation
messages: Nucleus

8355:smim22.L
gene id: 8355:smim22.L
uniprot id: A0A1L8EYX6
uniprot id: A0A974C0Z8
names: Subcellular Location Annotation
messages: Membrane

8355:atp2b3.L
gene id: 8355:atp2b3.L
uniprot id: A0A8J1LHQ9
uniprot id: A0A8J1LHU7
uniprot id: A0A8J1LID5
uniprot id: A0A8J1LJ42
uniprot id: A0A8J1LK80
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:smarcad1.S
gene id: 8355:smarcad1.S
uniprot id: A0A1L8HMC3
uniprot id: A0A974DU24
names: Subcellular Location Annotation
messages: Chromosome

8355:LOC108713254
gene id: 8355:LOC108713254
uniprot id: A0A8J0UY99
uniprot id: A0A8J1MS50
uniprot id: A0A8J1MTH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

8355:psmg1.L
gene id: 8355:psmg1.L
uniprot id: Q05AX3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PSMG1 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.
messages: Cytoplasm
messages: Degraded by the proteasome upon completion of 20S proteasome maturation.
messages: Endoplasmic reticulum
messages: Forms a heterodimer with psmg2.

8355:slc30a2.S
gene id: 8355:slc30a2.S
uniprot id: A0A1L8H799
uniprot id: A0A8J0UN78
uniprot id: A0A974HVJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

8355:trhr.L
gene id: 8355:trhr.L
uniprot id: A0A1L8FZU0
uniprot id: A0A974CRK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

8355:cryba1.2.L
gene id: 8355:cryba1.2.L
uniprot id: A0A8J0UDY3
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:sec61g.L
gene id: 8355:sec61g.L
uniprot id: A0A1L8FWK5
uniprot id: A0A974CNA7
uniprot id: Q66KU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (By similarity). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (By similarity).
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63 (By similarity). The SEC61 channel associates with the multi-pass translocon (MPT) complex (By similarity).

8355:ptprd.S
gene id: 8355:ptprd.S
uniprot id: A0A8J1LKE7
uniprot id: A0A8J1LKH2
uniprot id: A0A8J1LKH9
uniprot id: A0A8J1LKI9
uniprot id: A0A8J1LKJ5
uniprot id: A0A8J1LKJ9
uniprot id: A0A8J1LKK1
uniprot id: A0A8J1LKK6
uniprot id: A0A8J1LKK9
uniprot id: A0A8J1LKL5
uniprot id: A0A8J1LKN2
uniprot id: A0A8J1LKQ7
uniprot id: A0A8J1LKV1
uniprot id: A0A8J1LKX2
uniprot id: A0A8J1LLA9
uniprot id: A0A8J1LLB6
uniprot id: A0A8J1LLD8
uniprot id: A0A8J1LLH0
uniprot id: A0A8J1LLK2
uniprot id: A0A8J1LLL9
uniprot id: A0A8J1LLN1
uniprot id: A0A8J1LLN4
uniprot id: A0A8J1LLP1
uniprot id: A0A8J1LLP4
uniprot id: A0A8J1LLP6
uniprot id: A0A8J1LLQ5
uniprot id: A0A8J1LLR9
uniprot id: A0A8J1LLS6
uniprot id: A0A8J1LLV6
uniprot id: A0A8J1LLY0
uniprot id: A0A8J1LLY5
uniprot id: A0A8J1LLZ0
uniprot id: A0A8J1LM05
uniprot id: A0A8J1LMS4
uniprot id: A0A8J1LMT0
uniprot id: A0A8J1LMT5
uniprot id: A0A8J1LMV2
uniprot id: A0A8J1LMV7
uniprot id: A0A8J1LMX6
uniprot id: A0A8J1LMZ4
uniprot id: A0A8J1LN10
uniprot id: A0A8J1LN16
uniprot id: A0A8J1LN46
uniprot id: A0A8J1LN61
uniprot id: A0A8J1LN80
uniprot id: B7ZS86
uniprot id: Q9IAJ1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.

8355:tf.S
gene id: 8355:tf.S
uniprot id: A0A8J1KRB1
uniprot id: P20233
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the transferrin family.
messages: Monomer.
messages: Plasma.
messages: Secreted
messages: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation (By similarity).

8355:LOC121396393
gene id: 8355:LOC121396393
uniprot id: A0A8J1LDX0
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:agmat.L
gene id: 8355:agmat.L
uniprot id: A0A1L8FPE8
uniprot id: A0A974HD18
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

8355:LOC108702347
gene id: 8355:LOC108702347
uniprot id: A0A1L8ERF0
uniprot id: A0A974BWI8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Nematocyst
messages: Target cell membrane

8355:LOC108696938
gene id: 8355:LOC108696938
uniprot id: A0A1L8FPR3
uniprot id: A0A8J0T441
uniprot id: A0A8J0TCD1
uniprot id: A0A974CIM6
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

8355:meaf6.S
gene id: 8355:meaf6.S
uniprot id: Q52KD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF6 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (By similarity).
messages: Component of the NuA4 histone acetyltransferase complex. Component of the hbo1 complex. Component of the moz/morf complex (By similarity).
messages: kinetochore
messages: nucleolus

8355:LOC108713902
gene id: 8355:LOC108713902
uniprot id: A0A8J0UZR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8355:dctn6.L
gene id: 8355:dctn6.L
uniprot id: A0A974I323
uniprot id: Q6IRC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
messages: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
messages: cytoskeleton

8355:ufd1.S
gene id: 8355:ufd1.S
uniprot id: A0A974DUQ5
uniprot id: Q6P704
names: Similarity
messages: Belongs to the UFD1 family.

8355:LOC108701202
gene id: 8355:LOC108701202
uniprot id: A0A1L8EUX3
uniprot id: A0A974BYH8
names: Similarity
messages: Belongs to the sulfatase family.

8355:ada2.L
gene id: 8355:ada2.L
uniprot id: Q2VQV9
names: Cofactor
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Stimulates cell proliferation.
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Expression starts at stage 20 in the somites. At stage 22 is also detected in the cement gland, and at stage 30 is expressed in the somites, pronephros, eye, cement gland, neural tube, and neural floor plate.
messages: Morpholino knockdown of the protein results in reduced body size, abnormalities of the body axis, and changes in expression of developmental marker genes.
messages: Secreted

8355:slc10a7.L
gene id: 8355:slc10a7.L
uniprot id: Q52KD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization. Also involved in the regulation of cellular calcium homeostasis. Does not show transport activity towards bile acids or steroid sulfates.

8355:eif4ebp2.S
gene id: 8355:eif4ebp2.S
uniprot id: A0A974H9U8
uniprot id: Q6DJI1
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

8355:dlx3.S
gene id: 8355:dlx3.S
uniprot id: A0A1L8EL03
uniprot id: A0A974H096
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

8355:rab3gap2.L
gene id: 8355:rab3gap2.L
uniprot id: A0A1L8G6V3
uniprot id: A0A974CTI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP regulatory subunit family.
messages: Cytoplasm

8355:sfr1.L
gene id: 8355:sfr1.L
uniprot id: A0A1L8FJ76
uniprot id: A0A974CEC8
uniprot id: Q68F53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SFR1/MEI5 family.
messages: Component of the swi5-sfr1 complex, a complex required for double-strand break repair via homologous recombination (By similarity).
messages: Component of the swi5-sfr1 complex.
messages: Nucleus

8355:slc35d2.S
gene id: 8355:slc35d2.S
uniprot id: A0A1L8HPC4
uniprot id: A0A974DTP1
names: Subcellular Location Annotation
messages: Membrane

8355:wscd1.L
gene id: 8355:wscd1.L
uniprot id: A0A1L8HDU6
uniprot id: A0A8J1M7X8
uniprot id: A0A974DLN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WSCD family.
messages: Golgi apparatus membrane
messages: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.

8355:LOC121402025
gene id: 8355:LOC121402025
uniprot id: A0A310U939
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108716497
gene id: 8355:LOC108716497
uniprot id: A0A8J1KMF8
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

8355:LOC108703398
gene id: 8355:LOC108703398
uniprot id: A0A8J0U4V5
names: Similarity
messages: Belongs to the FAM47 family.

8355:rassf3.L
gene id: 8355:rassf3.L
uniprot id: A0A8J0US65
names: Subcellular Location Annotation
messages: cytoskeleton

8355:celf2.L
gene id: 8355:celf2.L
uniprot id: A0A8J0UQX3
uniprot id: A0A8J1MGG7
uniprot id: A0A8J1MGH2
uniprot id: A0A8J1MGH5
uniprot id: A0A8J1MGH7
uniprot id: A0A8J1MGI0
uniprot id: A0A8J1MGI2
uniprot id: A0A8J1MH06
uniprot id: A0A8J1MH11
uniprot id: A0A8J1MH17
uniprot id: A0A8J1MH21
uniprot id: A0A8J1MHE3
uniprot id: A0A8J1MHE9
uniprot id: A0A8J1MHF4
uniprot id: A0A8J1MHF8
uniprot id: A0A8J1MHG4
uniprot id: A0A8J1MIC1
uniprot id: A0A8J1MIC6
uniprot id: A0A8J1MID1
uniprot id: A0A8J1MID6
uniprot id: Q7ZXE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus
messages: RNA-binding protein implicated in the regulation of several post-transcriptional events. May be involved in pre-mRNA alternative splicing, mRNA translation repression and stability (By similarity).

8355:LOC108710329
gene id: 8355:LOC108710329
uniprot id: A0A8J1MNC9
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108699574
gene id: 8355:LOC108699574
uniprot id: A0A1L8FBS9
uniprot id: A0A974C9Y9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:LOC108701229
gene id: 8355:LOC108701229
uniprot id: A0A1L8EV47
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:cdc20b.L
gene id: 8355:cdc20b.L
uniprot id: A0A1L8I2C5
uniprot id: A0A974I655
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the WD repeat CDC20/Fizzy family.
messages: Cytoplasm
messages: Expressed in multiciliated cells (MCCs).
messages: In neurula stage 14 and 17, expressed in epidermal cells but not in the neural plate.
messages: Protein regulator of centriole-deuterosome disengagement and subsequently participates in the ciliogenesis in multiciliated cells (MCCs).
messages: Specifically detected during the phase of centriole amplification.

8355:toe1.L
gene id: 8355:toe1.L
uniprot id: A0A1L8GM42
uniprot id: A0A974D4G2
names: Similarity
messages: Belongs to the CAF1 family.

8355:LOC121397333
gene id: 8355:LOC121397333
uniprot id: A0A1L8FBT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:pin4.L
gene id: 8355:pin4.L
uniprot id: A0A1L8F6N9
uniprot id: A0A974H708
uniprot id: A0A974H719
uniprot id: Q6NRQ0
names: Similarity
messages: Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.

8355:cxcr5.S
gene id: 8355:cxcr5.S
uniprot id: A0A8J1LE70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:dvl3.L
gene id: 8355:dvl3.L
uniprot id: A0A8J0V923
uniprot id: A0A8J0V9M9
uniprot id: A0A8J1KLD8
uniprot id: Q6DKE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the DSH family.
messages: Cytoplasm
messages: Expressed throughout the epidermis.
messages: Involved in the signal transduction pathway mediated by multiple Wnt genes (By similarity). Required during ciliogenesis for the docking of basal bodies to the apical plasma membrane.

8355:lmbrd2.L
gene id: 8355:lmbrd2.L
uniprot id: Q7ZYA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIMR family.
messages: Cell membrane
messages: May associate with G-protein coupled receptors and regulate downstream signaling pathways.

8355:LOC108699340
gene id: 8355:LOC108699340
uniprot id: A0A1L8FC01
uniprot id: A0A974C9L4
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

8355:vwc2l.2.S
gene id: 8355:vwc2l.2.S
uniprot id: A0A1L8GFR2
uniprot id: A0A974D1Q9
names: Subcellular Location Annotation
messages: Synapse

8355:c1d.L
gene id: 8355:c1d.L
uniprot id: A0A974CUK3
uniprot id: Q3KPR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the C1D family.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus
messages: Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
messages: nucleolus

8355:sprtn.S
gene id: 8355:sprtn.S
uniprot id: A0A1L8G2K9
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autocatalytically cleaved in response to double-stranded DNA-binding: autocatalytic cleavage takes place in trans and leads to inactivation.
messages: Belongs to the Spartan family.
messages: Chromosome
messages: DNA-binding activates the protease activity: single-stranded DNA-binding specifically activates ability to cleave covalent DNA-protein cross-links (DPCs) (By similarity). In contrast, double-stranded DNA-binding specifically activates autocatalytic cleavage, and subsequent inactivation (By similarity).
messages: DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity (PubMed:30595436). DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde (By similarity). Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis (By similarity). Acts as a pleiotropic protease for DNA-binding proteins cross-linked with DNA, such as top1, top2a, histones H3 and H4 (By similarity). Mediates degradation of DPCs that are not ubiquitinated, while it is not able to degrade ubiquitinated DPCs (PubMed:30595436). SPRTN activation requires polymerase collision with DPCs followed by helicase bypass of DPCs (PubMed:30595436). May also act as a 'reader' of ubiquitinated pcna: facilitates chromatin association of rad18 and is required for efficient pcna monoubiquitination, promoting a feed-forward loop to enhance pcna ubiquitination and translesion DNA synthesis (By similarity). Acts as a regulator of translesion DNA synthesis by recruiting vcp/p97 to sites of DNA damage (By similarity).
messages: Homodimer.
messages: Nucleus
messages: The UBZ4-type zinc fingers mediate binding to 'Lys-48'- and 'Lys-63'-linked polyubiquitin.

8355:ebf2.S
gene id: 8355:ebf2.S
uniprot id: A0A8J0USX1
uniprot id: A0A8J0UU48
uniprot id: A0A8J0UXF1
uniprot id: B7ZRJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: May play a pivotal role in the transcriptional cascade that specifies primary neurons in embryos. Stabilizes the higher neural potential of selected progenitor cells that express neurog2/X-ngnr-1 by maintaining Delta-Notch signaling. Thus ensures the transition between neural competence and irreversible commitment to a neural fate. Also promotes neuronal differentiation by activating neurod1 expression, directly or indirectly (By similarity).
messages: Nucleus

8355:c9orf78.L
gene id: 8355:c9orf78.L
uniprot id: Q640Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TLS1 family.
messages: Nucleus

8355:mmp16.S
gene id: 8355:mmp16.S
uniprot id: A0A1L8FTH5
uniprot id: A0A8J0T797
uniprot id: A0A974HED1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

8355:scrn1.L
gene id: 8355:scrn1.L
uniprot id: A0A1L8FW62
uniprot id: Q6GLL9
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

8355:pafah1b1.S
gene id: 8355:pafah1b1.S
uniprot id: A0A1L8H632
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Can self-associate. Interacts with dynein, dynactin, NDE1 and NDEL1.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
messages: centrosome
messages: cytoskeleton

8355:LOC108698499
gene id: 8355:LOC108698499
uniprot id: A0A1L8F836
uniprot id: A0A974H7G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

8355:znf395.S
gene id: 8355:znf395.S
uniprot id: Q6DFC8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:acot2.S
gene id: 8355:acot2.S
uniprot id: Q6NTQ4
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

8355:LOC108696581
gene id: 8355:LOC108696581
uniprot id: A0A8J1L6X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAS10 family.
messages: nucleolus

8355:LOC108716280
gene id: 8355:LOC108716280
uniprot id: A0A8J1KR35
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:stam.S
gene id: 8355:stam.S
uniprot id: A0A8J0VLJ8
uniprot id: A0A8J0VLW8
uniprot id: A0A8J0VMN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane

8355:golph3l.S
gene id: 8355:golph3l.S
uniprot id: A0A974C4S3
uniprot id: Q5PPU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Homooligomer.
messages: Membrane
messages: Phosphatidylinositol-4-phosphate-binding protein that may play a role in the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane.
messages: trans-Golgi network membrane

8355:vapa.L
gene id: 8355:vapa.L
uniprot id: Q8AVC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:chia.S
gene id: 8355:chia.S
uniprot id: A0A1L8H6V7
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

8355:cpt1al.L
gene id: 8355:cpt1al.L
uniprot id: A0A8J0T5R8
uniprot id: A0A8J0T8W6
uniprot id: A0A974CHX4
uniprot id: Q7ZWK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

8355:ccar1.L
gene id: 8355:ccar1.L
uniprot id: Q641G3
names: Function
names: Subcellular Location Annotation
messages: Transcriptional coactivator for nuclear receptors which may play an important role in regulating cell growth and apoptosis.
messages: perinuclear region

8355:LOC108695857
gene id: 8355:LOC108695857
uniprot id: A0A1L8FME4
uniprot id: A0A974CHH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:rpl26.L
gene id: 8355:rpl26.L
uniprot id: A0A974HSK0
uniprot id: Q6DJQ0
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

8355:zdhhc9.L
gene id: 8355:zdhhc9.L
uniprot id: A0A8J0TJG7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:lix1.S
gene id: 8355:lix1.S
uniprot id: A0A1L8HR54
uniprot id: A0A974DW36
names: Similarity
messages: Belongs to the LIX1 family.

8355:calcr.L
gene id: 8355:calcr.L
uniprot id: A0A8J0VG73
uniprot id: A0A8J1KZY2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Interacts with GPRASP2.
messages: Membrane

8355:lefty.S
gene id: 8355:lefty.S
uniprot id: Q9DFC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

8355:LOC108718508
gene id: 8355:LOC108718508
uniprot id: A0A1L8FX23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

8355:epor.L
gene id: 8355:epor.L
uniprot id: Q4W815
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Cell membrane
messages: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases (By similarity).
messages: Expressed in the ventral blood island from stage 28 through to stage 36. Expressed in the circulating blood by stage 40. In the adult, highly expressed in peripheral blood cells including immature erythrocytes and basophils, and moderately expressed in the hematopoietic organs: liver, kidney and spleen. Expressed at a low level in adult brain.
messages: First expressed at a low level at stage 18 (late neurula), with high levels of expression seen from stage 32 through to stage 48 (tadpole).
messages: Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation.
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.

8355:cckbr.L
gene id: 8355:cckbr.L
uniprot id: A0A974DRP2
uniprot id: P70031
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Brain and stomach.
messages: Cell membrane
messages: Membrane
messages: Receptor for cholecystokinin. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Has high affinity for CCK-8 and low affinities for gastrin-17-I, CCK-4, and unsulfated CCK-8.

8355:LOC108701063
gene id: 8355:LOC108701063
uniprot id: A0A1L8EU10
uniprot id: A0A974H392
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:samm50.L
gene id: 8355:samm50.L
uniprot id: A0A8J1MH74
uniprot id: Q7ZWS5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex (also known as MINOS or MitOS complex).
messages: Belongs to the SAM50/omp85 family.
messages: Its C-terminal part seems to contain many membrane-spanning sided beta-sheets, that have the potential to adopt a transmembrane beta-barrel type structure.
messages: May play a role in the maintenance of the structure of mitochondrial cristae.
messages: Mitochondrion outer membrane

8355:trim71.S
gene id: 8355:trim71.S
uniprot id: A0A1L8FRI2
uniprot id: A0A8J0VJW1
uniprot id: A0A8J0VLW5
uniprot id: A0A974CK95
names: Similarity
messages: Belongs to the TRIM/RBCC family.

8355:slc22a15.2.S
gene id: 8355:slc22a15.2.S
uniprot id: Q7ZX53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Membrane
messages: Probably transports organic cations.

8355:nkiras1.S
gene id: 8355:nkiras1.S
uniprot id: A0A1L8FRE4
uniprot id: A0A1L8FRI5
uniprot id: A0A974HDQ3
uniprot id: A0A974HE46
uniprot id: A0JMW9
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

8355:ddx47.S
gene id: 8355:ddx47.S
uniprot id: A0A1L8GGU4
uniprot id: A0A8J1KJP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.
messages: Cytoplasm
messages: Nucleus

8355:LOC108701438
gene id: 8355:LOC108701438
uniprot id: A0A1L8EWY7
uniprot id: A0A974H486
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

8355:crbn.S
gene id: 8355:crbn.S
uniprot id: A0A1L8GHL3
uniprot id: A0A8J1KJZ1
uniprot id: A0A974HMG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRBN family.
messages: Nucleus

8355:LOC108702955
gene id: 8355:LOC108702955
uniprot id: A0A1L8ENW7
uniprot id: A0A8J0U0B3
uniprot id: A0A8J1LX38
names: Similarity
messages: Belongs to the ARTD/PARP family.

8355:pik3r2.L
gene id: 8355:pik3r2.L
uniprot id: A0A1L8HWT4
uniprot id: A0A8J0V0X9
uniprot id: A0A974E0G6
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

8355:dnmbp.S
gene id: 8355:dnmbp.S
uniprot id: A0A1L8FEW2
uniprot id: A0A8J0TET2
uniprot id: A0A974H9T7
names: Subcellular Location Annotation
messages: Cell junction
messages: Golgi stack
messages: Synapse
messages: cytoskeleton

8355:haus1.L
gene id: 8355:haus1.L
uniprot id: A0A8J1L9M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS1 family.
messages: spindle

8355:LOC108717497
gene id: 8355:LOC108717497
uniprot id: A0A8J1KUL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
messages: Interacts with NIP7.
messages: Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.
messages: nucleolus

8355:snrnp27.S
gene id: 8355:snrnp27.S
uniprot id: A0A974D7N6
uniprot id: Q6GLZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNUT3 family.
messages: May play a role in mRNA splicing.
messages: Nucleus
messages: Part of a tri-snRNP complex.

8355:tie1.L
gene id: 8355:tie1.L
uniprot id: A0A1L8GM27
uniprot id: A0A8J1MX47
uniprot id: A0A8J1MYK7
uniprot id: A0A974D6C5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:LOC108705331
gene id: 8355:LOC108705331
uniprot id: A0A8J0U6P1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:acp1.L
gene id: 8355:acp1.L
uniprot id: A0A1L8GBP9
uniprot id: A0A974HK94
uniprot id: Q5PQ02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

8355:LOC108706777
gene id: 8355:LOC108706777
uniprot id: A0A1L8HMM1
uniprot id: A0A8J1M1R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8355:arl6.S
gene id: 8355:arl6.S
uniprot id: A0A8J1M4Y1
uniprot id: Q2ABY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: cilium membrane

8355:tubgcp3.L
gene id: 8355:tubgcp3.L
uniprot id: A0A1L8HH01
uniprot id: A0A8J0UG72
uniprot id: A0A8J0UIP8
uniprot id: A0A974HZ10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

8355:sntg1.S
gene id: 8355:sntg1.S
uniprot id: A0A8J1L2M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: cytoskeleton

8355:tspan18.S
gene id: 8355:tspan18.S
uniprot id: A0A974CXV8
uniprot id: Q6GP44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8355:LOC108697650
gene id: 8355:LOC108697650
uniprot id: A0A1L8FG82
uniprot id: A0A974CCF8
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108695939
gene id: 8355:LOC108695939
uniprot id: A0A1L8FNY2
uniprot id: A0A974CH39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

8355:ppp1r3b.L
gene id: 8355:ppp1r3b.L
uniprot id: Q5BL87
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown (By similarity).
messages: Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity (By similarity).
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to PYGL.

8355:LOC108711464
gene id: 8355:LOC108711464
uniprot id: A0A8J0USL9
uniprot id: A0A8J1MMX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

8355:mgst1.L
gene id: 8355:mgst1.L
uniprot id: Q6NTT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

8355:tp53i11.L
gene id: 8355:tp53i11.L
uniprot id: A0JPG8
names: Subcellular Location Annotation
messages: Membrane

8355:LOC121393966
gene id: 8355:LOC121393966
uniprot id: A0A8J1KR28
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:prc1.L
gene id: 8355:prc1.L
uniprot id: A0A8J0UVR4
uniprot id: A0A8J1MLW1
uniprot id: A0A8J1MLW6
uniprot id: A0A8J1MM00
uniprot id: A0A8J1MMU7
uniprot id: A0A8J1MMW2
uniprot id: A0A8J1MMW7
uniprot id: A0A8J1MNZ3
names: Similarity
messages: Belongs to the MAP65/ASE1 family.

8355:ccndx.L
gene id: 8355:ccndx.L
uniprot id: A0A974CHY2
uniprot id: Q641B3
names: Similarity
messages: Belongs to the cyclin family.

8355:tsr2.L
gene id: 8355:tsr2.L
uniprot id: A0A8J1LHX7
names: Function
names: Similarity
messages: Belongs to the TSR2 family.
messages: May be involved in 20S pre-rRNA processing.

8355:LOC108713277
gene id: 8355:LOC108713277
uniprot id: A0A1L8GVE2
uniprot id: A0A8J0V1Y6
uniprot id: A0A974DBN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

8355:LOC108717217
gene id: 8355:LOC108717217
uniprot id: A0A1L8GBT6
uniprot id: A0A8J0V9N8
uniprot id: A0A8J0VD07
uniprot id: A0A974CXS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

8355:katnip.L
gene id: 8355:katnip.L
uniprot id: Q5XK85
names: Function
names: Subcellular Location Annotation
messages: May control cilium integrity.
messages: cilium axoneme
messages: cilium basal body
messages: cytoskeleton

8355:acly.L
gene id: 8355:acly.L
uniprot id: A0A1L8ERV0
uniprot id: A0A8J0TTH1
uniprot id: A0A8J0TUM0
uniprot id: A0A974BW21
uniprot id: Q5U5A8
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
messages: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.

8355:LOC108704405
gene id: 8355:LOC108704405
uniprot id: A0A8J0U578
uniprot id: A0A8J0U7A9
uniprot id: A0A8J1KM60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BOD1 family.
messages: centrosome
messages: kinetochore

8355:cpa6.L
gene id: 8355:cpa6.L
uniprot id: A0A974CQ26
uniprot id: Q8AVS2
names: Similarity
messages: Belongs to the peptidase M14 family.

8355:LOC121393744
gene id: 8355:LOC121393744
uniprot id: A0A8J1KNY8
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

8355:slc9a1.L
gene id: 8355:slc9a1.L
uniprot id: A0A1L8HE98
uniprot id: A0A8J0U6C9
uniprot id: A0A974HY33
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

8355:chmp4b.S
gene id: 8355:chmp4b.S
uniprot id: A0A1L8EMW7
uniprot id: A0A974H0S4
names: Similarity
messages: Belongs to the SNF7 family.

8355:cpa1.L
gene id: 8355:cpa1.L
uniprot id: Q5U553
names: Similarity
messages: Belongs to the peptidase M14 family.

8355:cdr2l.L
gene id: 8355:cdr2l.L
uniprot id: A0A1L8EUJ8
uniprot id: A0A974BY42
names: Similarity
messages: Belongs to the CDR2 family.

8355:ltb4r2.S
gene id: 8355:ltb4r2.S
uniprot id: A0A1L8HPN8
uniprot id: A0A974DU93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

8355:c11orf58.S
gene id: 8355:c11orf58.S
uniprot id: A0A974D0N6
uniprot id: Q6DDU5
names: Similarity
messages: Belongs to the SMAP family.

8355:LOC121396554
gene id: 8355:LOC121396554
uniprot id: A0A8J1LDM6
names: Subcellular Location Annotation
messages: Secreted

8355:LOC108698796
gene id: 8355:LOC108698796
uniprot id: A0A8J0TKW9
uniprot id: A0A8J1LIW9
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily.

8355:wnt8a.S
gene id: 8355:wnt8a.S
uniprot id: A0A1L8GVI0
uniprot id: A0A974HRR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8355:hyls1.S
gene id: 8355:hyls1.S
uniprot id: A0A1L8ER70
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYLS1 family.
messages: Morpholino knockdown results in a specific loss of cilia, with no effect on the number of cells with multiple basal bodies or the number of basal bodies per cell.
messages: Plays an important role in ciliogenesis. Required for apical targeting/anchoring of centrioles at the plasma membrane.
messages: centriole
messages: cilium

8355:LOC108699267
gene id: 8355:LOC108699267
uniprot id: A0A1L8HU99
uniprot id: A0A974DY28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108710370
gene id: 8355:LOC108710370
uniprot id: A0A8J1MIK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Membrane

8355:pex10.S
gene id: 8355:pex10.S
uniprot id: A0A1L8FG46
uniprot id: A0A8J0TEM8
uniprot id: A0A974HAG6
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of the PEX2-PEX10-PEX12 retrotranslocation channel.
messages: E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:35931083). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase (By similarity). When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation (By similarity).
messages: Membrane
messages: Peroxisome membrane
messages: The E3 ubiquitin-protein ligase activity is stimulated by PEX12.
messages: The three subunits of the retrotranslocation channel (PEX2, PEX10 and PEX12) coassemble in the membrane into a channel with an open 10 Angstrom pore. The RING-type zinc-fingers that catalyze PEX5 receptor ubiquitination are positioned above the pore on the cytosolic side of the complex.

8355:p3h2.L
gene id: 8355:p3h2.L
uniprot id: A0A1L8G9Z2
uniprot id: A0A8J1KSJ6
uniprot id: A0A974CXS5
names: Similarity
messages: Belongs to the leprecan family.

8355:rtbdn.L
gene id: 8355:rtbdn.L
uniprot id: Q0IHI5
names: Similarity
messages: Belongs to the folate receptor family.

8355:LOC108713679
gene id: 8355:LOC108713679
uniprot id: A0A8J1MUJ1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natural cytotoxicity receptor (NCR) family.
messages: Cell membrane
messages: Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6.
messages: Membrane

8355:khdrbs2.S
gene id: 8355:khdrbs2.S
uniprot id: A0A1L8G3H8
uniprot id: A0A974CRE5
names: Similarity
messages: Belongs to the KHDRBS family.

8355:cenpn.S
gene id: 8355:cenpn.S
uniprot id: A0A8J1MZW0
uniprot id: A0A8J1N0T0
uniprot id: Q5XH29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-N/CHL4 family.
messages: Nucleus
messages: Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
messages: centromere

8355:nr6a1.L
gene id: 8355:nr6a1.L
uniprot id: A0A1L8F6D0
uniprot id: A0A8J0TA08
uniprot id: A0A8J0TG49
uniprot id: A0A8J0THW9
uniprot id: A0A8J0TIP0
uniprot id: A0A8J1LFV2
uniprot id: A0A8J1LFV7
uniprot id: A0A8J1LFY3
uniprot id: A0A8J1LFY8
uniprot id: A0A8J1LHA5
uniprot id: A0A8J1LHB0
uniprot id: A0A974C681
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

8355:ppp6r1.L
gene id: 8355:ppp6r1.L
uniprot id: A0A8J0T812
uniprot id: A0A8J0T814
uniprot id: A0A8J1L5T2
uniprot id: A0A8J1L6T9
uniprot id: Q6PCI0
names: Similarity
messages: Belongs to the SAPS family.

8355:gpr35.L
gene id: 8355:gpr35.L
uniprot id: A0A1L8GAX1
uniprot id: A0A974CW92
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:tmem203.S
gene id: 8355:tmem203.S
uniprot id: Q6GNX5
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Involved in the regulation of cellular calcium homeotasis.

8355:aplp2.L
gene id: 8355:aplp2.L
uniprot id: A0A1L8FL54
uniprot id: A0A8J0Q884
uniprot id: A0A8J0T8B2
uniprot id: A0A8J0T8C1
uniprot id: A0A8J0T997
uniprot id: A0A8J1L4B2
uniprot id: A0A8J1L4B4
uniprot id: A0A8J1L4D6
uniprot id: A0A8J1L715
uniprot id: A0A974CFC5
uniprot id: Q6AX20
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:mfsd14b.L
gene id: 8355:mfsd14b.L
uniprot id: A0A1L8HXC9
uniprot id: A0A8J1KLQ2
uniprot id: A0A974I446
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

8355:LOC108717036
gene id: 8355:LOC108717036
uniprot id: A0A1L8GAG6
uniprot id: A0A8J0V8Y0
uniprot id: A0A974CY52
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108719729
gene id: 8355:LOC108719729
uniprot id: A0A1L8FT06
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

8355:yipf3.L
gene id: 8355:yipf3.L
uniprot id: Q3B8G4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis (By similarity).
messages: cis-Golgi network membrane

8355:atp2a1.L
gene id: 8355:atp2a1.L
uniprot id: A0A8J1LR57
uniprot id: A0A8J1LSE6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

8355:cemip.S
gene id: 8355:cemip.S
uniprot id: A0A1L8GSM0
uniprot id: A0A8J0UVD4
uniprot id: A0A974D7H9
names: Similarity
messages: Belongs to the CEMIP family.

8355:XB5748694.L
gene id: 8355:XB5748694.L
uniprot id: Q641G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

8355:epn3.S
gene id: 8355:epn3.S
uniprot id: A0A1L8EMS6
uniprot id: A0A974H0U4
names: Similarity
messages: Belongs to the epsin family.

8355:irs4.L
gene id: 8355:irs4.L
uniprot id: Q5RJW5
names: Function
names: PTM
messages: Phosphorylated by INSR.
messages: Potentiates insulin signaling.

8355:fli1b.L
gene id: 8355:fli1b.L
uniprot id: A0A1L8FPG5
uniprot id: A0A8J1L9W0
uniprot id: A0A974CHI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8355:ccdc85a.L
gene id: 8355:ccdc85a.L
uniprot id: A0A1L8G744
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

8355:LOC108710502
gene id: 8355:LOC108710502
uniprot id: A0A1L8H470
uniprot id: A0A974DGZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:abhd8.L
gene id: 8355:abhd8.L
uniprot id: Q6AX59
names: Similarity
messages: Belongs to the AB hydrolase superfamily.

8355:psmb5.L
gene id: 8355:psmb5.L
uniprot id: A0A1L8HYU0
uniprot id: A0A974I4T4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

8355:MGC68606
gene id: 8355:MGC68606
uniprot id: A0A974CD38
uniprot id: Q6PG53
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

8355:sec23b.L
gene id: 8355:sec23b.L
uniprot id: A0A8J1KLD4
uniprot id: Q6DJE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

8355:ddx23.S
gene id: 8355:ddx23.S
uniprot id: A0A1L8H9N0
uniprot id: A0A974DKQ1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:fbxo34.S
gene id: 8355:fbxo34.S
uniprot id: A0A1L8EZX0
uniprot id: A0A974H561
uniprot id: A3KNB4
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

8355:LOC121401305
gene id: 8355:LOC121401305
uniprot id: A0A1L8H3Z2
names: Subcellular Location Annotation
messages: Membrane

8355:pank4.S
gene id: 8355:pank4.S
uniprot id: A0A1L8FG60
uniprot id: A0A974HA82
names: Similarity
names: Subunit
messages: Belongs to the type II pantothenate kinase family.
messages: Homodimer. Interacts with PKM.
messages: In the N-terminal section; belongs to the type II pantothenate kinase family.

8355:LOC121394622
gene id: 8355:LOC121394622
uniprot id: A0A8J1L0D8
names: Similarity
messages: Belongs to the peptidase C2 family.

8355:gphn.S
gene id: 8355:gphn.S
uniprot id: A0A8J1LKM0
uniprot id: A0A8J1LKM5
uniprot id: A0A8J1LKN0
uniprot id: A0A8J1LKN6
uniprot id: A0A8J1LKP2
uniprot id: A0A8J1LKS7
uniprot id: A0A8J1LKT1
uniprot id: A0A8J1LKT6
uniprot id: A0A8J1LKU1
uniprot id: A0A8J1LKU6
uniprot id: A0A8J1LLK9
uniprot id: A0A8J1LLL5
uniprot id: A0A8J1LLM0
uniprot id: A0A8J1LLM6
uniprot id: A0A8J1LLW1
uniprot id: A0A8J1LLW6
uniprot id: A0A8J1LLX0
uniprot id: A0A8J1LLX5
uniprot id: A0A8J1LN33
uniprot id: A0A8J1LN38
uniprot id: A0A8J1LN51
uniprot id: A0A8J1LN56
uniprot id: Q6GQZ6
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
messages: In the C-terminal section; belongs to the MoeA family.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

8355:ext1.S
gene id: 8355:ext1.S
uniprot id: Q52KD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane

8355:clasp1.L
gene id: 8355:clasp1.L
uniprot id: A0A8J1LPW7
uniprot id: A0A8J1LPX4
uniprot id: A0A8J1LPX9
uniprot id: A0A8J1LQ08
uniprot id: A0A8J1LQ14
uniprot id: A0A8J1LQ19
uniprot id: A0A8J1LQT8
uniprot id: A0A8J1LQU4
uniprot id: A0A8J1LQV0
uniprot id: A0A8J1LRA5
uniprot id: A0A8J1LRB2
uniprot id: A0A8J1LRB9
uniprot id: A0A8J1LRC5
uniprot id: A0A8J1LSA8
uniprot id: A0A8J1LSB5
uniprot id: A0A8J1LSC1
uniprot id: A0A8J1LSC7
uniprot id: Q4U0G1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLASP family.
messages: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules during anaphase. Plays a crucial role in chromatin-induced microtubule formation. May also act at microtubule minus ends. May be involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN) (By similarity).
messages: centrosome
messages: cytoskeleton
messages: kinetochore
messages: spindle
messages: trans-Golgi network

8355:cdk2ap1.S
gene id: 8355:cdk2ap1.S
uniprot id: A0A1L8HQM6
uniprot id: A0A8J0TRA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDK2AP family.
messages: Nucleus

8355:rnf114.S
gene id: 8355:rnf114.S
uniprot id: A0A1L8ELG3
uniprot id: A0A8J0U0W0
uniprot id: A0A974BT85
names: Subunit
messages: Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.

8355:LOC108716305
gene id: 8355:LOC108716305
uniprot id: A0A8J0V9R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:LOC108706045
gene id: 8355:LOC108706045
uniprot id: A0A8J0U7R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:vangl1.L
gene id: 8355:vangl1.L
uniprot id: A0A1L8HBP1
uniprot id: A0A974HX91
uniprot id: Q32NQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

8355:LOC121397210
gene id: 8355:LOC121397210
uniprot id: A0A8J1LJ21
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:mutyh.L
gene id: 8355:mutyh.L
uniprot id: A0A8J0V207
uniprot id: A0A8J0V685
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs.
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

8355:neurod1.S
gene id: 8355:neurod1.S
uniprot id: A0A974BVI8
uniprot id: Q6GPW1
names: Subcellular Location Annotation
messages: Nucleus

8355:mrps33.L
gene id: 8355:mrps33.L
uniprot id: Q5U5B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

8355:LOC108695730
gene id: 8355:LOC108695730
uniprot id: A0A8J0T9S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:itk.L
gene id: 8355:itk.L
uniprot id: A0A1L8GWD8
uniprot id: A0A8J1MJN4
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

8355:ifi30.L
gene id: 8355:ifi30.L
uniprot id: A0A974E023
uniprot id: I3PB85
names: Similarity
names: Subunit
messages: Belongs to the GILT family.
messages: Dimer; disulfide-linked.

8355:LOC108702259
gene id: 8355:LOC108702259
uniprot id: A0A8J1LWZ2
names: Caution
names: Similarity
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:renbp.L
gene id: 8355:renbp.L
uniprot id: A0A974H735
uniprot id: Q52L39
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

8355:LOC108719724
gene id: 8355:LOC108719724
uniprot id: A0A8J1L2L2
uniprot id: A0A8J1L2L8
uniprot id: A0A8J1L5C6
names: Similarity
messages: Belongs to the OSBP family.

8355:fubp1.L
gene id: 8355:fubp1.L
uniprot id: A0A8J0Q691
uniprot id: A0A8J0V3K9
uniprot id: A0A974D364
uniprot id: Q6IRB9
names: Subcellular Location Annotation
messages: Nucleus

8355:selenoo.L
gene id: 8355:selenoo.L
uniprot id: A0A8J0QH16
names: Similarity
messages: Belongs to the SELO family.

8355:selenok.S
gene id: 8355:selenok.S
uniprot id: Q641S4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selenoprotein K family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity). Required for cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Required for palmitoylation (By similarity).

8355:LOC121399802
gene id: 8355:LOC121399802
uniprot id: A0A1L8HC75
names: Subcellular Location Annotation
messages: Secreted

8355:LOC108711814
gene id: 8355:LOC108711814
uniprot id: A0A8J0ULT7
uniprot id: A0A8J0USP0
uniprot id: A0A8J0UTS5
uniprot id: A0A8J0UX65
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108704179
gene id: 8355:LOC108704179
uniprot id: A0A8J1LYG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Cytoplasm

8355:ube2g2.L
gene id: 8355:ube2g2.L
uniprot id: A0A974BZS4
uniprot id: Q6DFI4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8355:abhd3.S
gene id: 8355:abhd3.S
uniprot id: A0A974CL41
uniprot id: Q52KD4
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

8355:LOC108709892
gene id: 8355:LOC108709892
uniprot id: A0A1L8HA31
uniprot id: A0A974DJJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

8355:b9d1.L
gene id: 8355:b9d1.L
uniprot id: A0A8J0TS76
uniprot id: Q6DFD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the B9D family.
messages: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).
messages: Part of the tectonic-like complex (also named B9 complex).
messages: cilium basal body

8355:LOC108704027
gene id: 8355:LOC108704027
uniprot id: A0A8J0U361
uniprot id: A0A8J1N0Z7
names: Similarity
messages: Belongs to the DCP1 family.

8355:LOC108708774
gene id: 8355:LOC108708774
uniprot id: A0A8J0U994
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108715857
gene id: 8355:LOC108715857
uniprot id: A0A1L8GHL2
uniprot id: A0A974D1G4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

8355:lgi2.S
gene id: 8355:lgi2.S
uniprot id: A0A1L8HL09
uniprot id: A0A974I0E5
names: Subcellular Location Annotation
messages: Secreted

8355:fmnl1.S
gene id: 8355:fmnl1.S
uniprot id: A0A1L8EL52
names: Similarity
messages: Belongs to the formin homology family.

8355:krt61.L
gene id: 8355:krt61.L
uniprot id: Q5XGT4
names: Similarity
messages: Belongs to the intermediate filament family.

8355:med25.L
gene id: 8355:med25.L
uniprot id: A0A1L8FNR4
uniprot id: A0A8J0T9Y4
uniprot id: A0A8J0TBZ1
uniprot id: A0A8J0TD87
uniprot id: A0A8J1L7Q1
uniprot id: A0A974HCS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 25 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8355:LOC121401476
gene id: 8355:LOC121401476
uniprot id: A0A8J1MM69
names: Similarity
messages: Belongs to the HARBI1 family.

8355:mrps30.S
gene id: 8355:mrps30.S
uniprot id: Q90Z99
names: Subcellular Location Annotation
messages: Mitochondrion

8355:ca2.L
gene id: 8355:ca2.L
uniprot id: A0A974HGC2
uniprot id: Q8AVG8
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

8355:hk1.L
gene id: 8355:hk1.L
uniprot id: A0A974CEL0
uniprot id: Q6GQB4
names: Similarity
messages: Belongs to the hexokinase family.

8355:creld1.L
gene id: 8355:creld1.L
uniprot id: A0A1L8GQ26
uniprot id: A0A974D7Q8
names: Similarity
messages: Belongs to the CRELD family.

8355:LOC108716876
gene id: 8355:LOC108716876
uniprot id: A0A8J0V865
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

8355:LOC100127301
gene id: 8355:LOC100127301
uniprot id: A9JS42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
messages: Secreted

8355:xkr8.S
gene id: 8355:xkr8.S
uniprot id: A0A1L8H7P9
uniprot id: A0A974DJ94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

8355:LOC121398920
gene id: 8355:LOC121398920
uniprot id: A0A8J1M0B2
names: Similarity
messages: Belongs to the cyclin family.

8355:LOC108718604
gene id: 8355:LOC108718604
uniprot id: A0A8J1KZ26
uniprot id: A0A8J1KZ34
names: Similarity
messages: Belongs to the FAM91 family.

8355:itgbl1.L
gene id: 8355:itgbl1.L
uniprot id: Q5M9B3
names: Domain
names: Subcellular Location Annotation
messages: Contains ten tandem EGF-like repeats strikingly similar to those found in the cysteine rich 'stalk-like' structure of integrin beta-subunits.
messages: Secreted

8355:dusp13.S
gene id: 8355:dusp13.S
uniprot id: A0A8J0U4S5
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

8355:cdk2.L
gene id: 8355:cdk2.L
uniprot id: Q6IRQ7
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:dop1b.L
gene id: 8355:dop1b.L
uniprot id: A0A8J1M709
uniprot id: A0A8J1M746
uniprot id: A0A8J1M826
names: Similarity
messages: Belongs to the dopey family.

8355:LOC108701241
gene id: 8355:LOC108701241
uniprot id: A0A1L8EV90
uniprot id: A0A974BZA7
names: Similarity
messages: Belongs to the ARTD/PARP family.

8355:LOC108704001
gene id: 8355:LOC108704001
uniprot id: A0A8J0U6C6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:eif3g.L
gene id: 8355:eif3g.L
uniprot id: A0A974DE22
uniprot id: Q641B2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.

8355:vps26c.L
gene id: 8355:vps26c.L
uniprot id: Q4FZN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN).
messages: Belongs to the VPS26 family.
messages: Component of the heterotrimeric retromer cargo-selective complex (CSC) which is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants.
messages: Cytoplasm
messages: Membrane

8355:LOC108707086
gene id: 8355:LOC108707086
uniprot id: A0A1L8HQ32
uniprot id: A0A8J0U1T5
uniprot id: A0A974DVU3
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

8355:XB5731801.S
gene id: 8355:XB5731801.S
uniprot id: A0A1L8ENU1
uniprot id: A0A974BUQ5
names: Similarity
messages: Belongs to the histone H2B family.

8355:cul3.S
gene id: 8355:cul3.S
uniprot id: A0A974CSL4
uniprot id: Q6GPF3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cullin family.
messages: Component of multiple BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes formed of cul3, rbx1 and a variable BTB domain-containing protein acting as both, adapter to cullin and substrate recognition subunit (By similarity). Interacts with btbd6 (PubMed:18855900).
messages: Neddylated. Attachment of NEDD8 is required for the E3 ubiquitin-protein ligase activity of the SCF-like complex.
messages: Nucleus
messages: Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit (By similarity). Involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division (By similarity). May play a role in the regulation of mittotic entry via ubiquitination of aurka (By similarity).

8355:ocm4.9.L
gene id: 8355:ocm4.9.L
uniprot id: A0A974H455
uniprot id: Q8AVP4
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

8355:LOC108700586
gene id: 8355:LOC108700586
uniprot id: A0A8J1LN20
names: Similarity
messages: Belongs to the PP1 inhibitor family.

8355:csnk2a2.S
gene id: 8355:csnk2a2.S
uniprot id: A0A1L8GF13
uniprot id: A0A8J1KIP8
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC108701326
gene id: 8355:LOC108701326
uniprot id: A0A1L8EVV0
uniprot id: A0A8J0TMD1
uniprot id: A0A974BZ95
names: Similarity
messages: Belongs to the calcium channel beta subunit family.

8355:LOC108719747
gene id: 8355:LOC108719747
uniprot id: A0A1L8FTN5
uniprot id: A0A974CMC9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:jagn1.L
gene id: 8355:jagn1.L
uniprot id: A0A974D5J8
uniprot id: Q5M7C7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the jagunal family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function.
messages: Membrane

8355:pds5b.L
gene id: 8355:pds5b.L
uniprot id: A0A1L8HIX8
uniprot id: Q498H0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDS5 family.
messages: Interacts with the cohesin complex.
messages: Nucleus
messages: Phosphorylated in mitotic cells.
messages: Plays a role in androgen-induced proliferative arrest (By similarity). Required for maintenance of sister chromatid cohesion during mitosis.

8355:chchd4.L
gene id: 8355:chchd4.L
uniprot id: Q6NU12
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes (By similarity). Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17 or MICU1. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria.
messages: Mitochondrion intermembrane space
messages: Monomer. Can form homooligomers.
messages: The CHCH domain contains a conserved twin Cys-X(9)-Cys motif which is required for import and stability of MIA40 in mitochondria.

8355:rcor1.L
gene id: 8355:rcor1.L
uniprot id: Q90WN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CoREST family.
messages: Component of a BHC histone deacetylase complex that contains KDM1A.
messages: Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates (By similarity).
messages: Expressed in territories in which neurogenesis takes place.
messages: Nucleus

8355:abca5.L
gene id: 8355:abca5.L
uniprot id: A0A1L8ERP1
uniprot id: A0A974BWY1
names: Subcellular Location Annotation
messages: Membrane

8355:nppa.S
gene id: 8355:nppa.S
uniprot id: Q0IH46
names: Subcellular Location Annotation
messages: Secreted

8355:zeb2.S
gene id: 8355:zeb2.S
uniprot id: A0A1L8ENX7
uniprot id: A0A8J1LWU9
uniprot id: A0A8J1LXQ1
uniprot id: Q5U4S2
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

8355:tgfbr2.S
gene id: 8355:tgfbr2.S
uniprot id: A0A8J0VQD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane
messages: Membrane raft

8355:tyw3.L
gene id: 8355:tyw3.L
uniprot id: Q641F8
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).

8355:LOC108697251
gene id: 8355:LOC108697251
uniprot id: A0A8J0TE35
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:ppp1r12a.L
gene id: 8355:ppp1r12a.L
uniprot id: A0A1L8GYQ0
uniprot id: A0A8J1MKM0
uniprot id: A0A8J1MLG8
uniprot id: A0A8J1MMP0
uniprot id: A0A974DCL7
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.

8355:usp4.S
gene id: 8355:usp4.S
uniprot id: A0A1L8GHB6
uniprot id: A0A8J0V3P2
uniprot id: A0A8J0V7T8
uniprot id: A0A974D1A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Nucleus

8355:taf3.L
gene id: 8355:taf3.L
uniprot id: Q5EAW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF3 family.
messages: Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein tbp, and a number of TBP-associated factors (TAFs).
messages: Nucleus
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of tbp and TBP-associated factors (TAFs).

8355:comt.2.S
gene id: 8355:comt.2.S
uniprot id: A0A1L8HQH3
uniprot id: A0A8J0U920
uniprot id: A0A974DUE9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.

8355:uchl3.L
gene id: 8355:uchl3.L
uniprot id: A0A974HYX5
uniprot id: Q5XHE2
names: Similarity
messages: Belongs to the peptidase C12 family.

8355:npbwr1.L
gene id: 8355:npbwr1.L
uniprot id: A0A1L8ET57
uniprot id: A0A974BXP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:galm.L
gene id: 8355:galm.L
uniprot id: A0A1L8G7Q7
uniprot id: A0A974HJ79
uniprot id: A1L2T0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldose epimerase family.
messages: Monomer.
messages: Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism.

8355:gucy2c.S
gene id: 8355:gucy2c.S
uniprot id: A0A1L8GGS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

8355:cab39.S
gene id: 8355:cab39.S
uniprot id: A0A1L8G4K9
uniprot id: A0A974CSD9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

8355:lpgat1.S
gene id: 8355:lpgat1.S
uniprot id: A0A1L8G1D6
uniprot id: A0A974CQX4
uniprot id: Q6P9I6
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

8355:kmt2d.L
gene id: 8355:kmt2d.L
uniprot id: A0A8J0U8A7
uniprot id: A0A8J0UGK2
uniprot id: A0A8J0UJ43
uniprot id: A0A8J1M9Y7
names: Subcellular Location Annotation
messages: Nucleus

8355:aqp12a.S
gene id: 8355:aqp12a.S
uniprot id: Q63ZK8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:LOC108696041
gene id: 8355:LOC108696041
uniprot id: A0A1L8FIG1
uniprot id: A0A8J1LAT5
uniprot id: A0A974CDQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: extracellular matrix

8355:cd40lg.S
gene id: 8355:cd40lg.S
uniprot id: A0A1L8F3A9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell surface
messages: Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.
messages: Homotrimer.

8355:LOC108703423
gene id: 8355:LOC108703423
uniprot id: A0A8J1MPK2
names: Subcellular Location Annotation
messages: Membrane

8355:csrnp1.S
gene id: 8355:csrnp1.S
uniprot id: A0A1L8FQF9
uniprot id: A0A8J1L167
uniprot id: A0A974CIB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

8355:gapvd1.S
gene id: 8355:gapvd1.S
uniprot id: A0A8J1LK41
uniprot id: A0A8J1LK46
uniprot id: A0A8J1LKA2
uniprot id: A0A8J1LKA6
uniprot id: A0A8J1LKB2
uniprot id: A0A8J1LL02
uniprot id: A0A8J1LL06
uniprot id: A0A8J1LLD5
uniprot id: A0A8J1LLE0
uniprot id: A0A8J1LMJ8
uniprot id: A0A8J1LMK4
uniprot id: A2RV61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking.
messages: Belongs to the GAPVD1 family.
messages: Endosome
messages: Membrane

8355:LOC108712674
gene id: 8355:LOC108712674
uniprot id: A0A1L8GRM1
uniprot id: A0A974HQC8
names: Similarity
messages: Belongs to the TGF-beta family.

8355:gpr34.L
gene id: 8355:gpr34.L
uniprot id: A0A1L8HF39
uniprot id: A0A974DN22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Orphan receptor.

8355:ano8.L
gene id: 8355:ano8.L
uniprot id: A0A1L8HXF4
uniprot id: A0A8J1KP08
uniprot id: A0A8J1KQN5
uniprot id: A0A974DZ58
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:mettl6.L
gene id: 8355:mettl6.L
uniprot id: A0A1L8FWG2
uniprot id: A0A8J0VJ79
uniprot id: A0A8J1KZ08
uniprot id: A0A974CM00
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

8355:psmd3.L
gene id: 8355:psmd3.L
uniprot id: A0A1L8ERX0
uniprot id: A0A974H2J6
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

8355:b3gnt9.L
gene id: 8355:b3gnt9.L
uniprot id: A0A1L8GKL3
uniprot id: A0A974D501
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:ncald.L
gene id: 8355:ncald.L
uniprot id: Q7SY75
names: Function
names: Similarity
messages: Belongs to the recoverin family.
messages: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity).

8355:cuedc2.S
gene id: 8355:cuedc2.S
uniprot id: Q6NU18
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUEDC2 family.
messages: Cytoplasm
messages: May play a role in targeting proteins for ubiquitination and subsequent proteasomal degradation.
messages: Nucleus
messages: Phosphorylated.

8355:pfkp.S
gene id: 8355:pfkp.S
uniprot id: A0A8J0VII5
uniprot id: A0A8J0VKV2
uniprot id: A0A8J0VM01
uniprot id: A0A8J1L0B3
uniprot id: A2RV78
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:mical3.L
gene id: 8355:mical3.L
uniprot id: A0A8J0U562
uniprot id: A0A8J1MJB8
uniprot id: A0A8J1MJD0
uniprot id: A0A8J1MJD5
uniprot id: A0A8J1MK32
uniprot id: A0A8J1MKC7
uniprot id: A0A8J1MLD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mical family.
messages: Cytoplasm

8355:ets1.L
gene id: 8355:ets1.L
uniprot id: A0A8J0T860
uniprot id: A0A8J0T861
uniprot id: A0A8J1L6W7
uniprot id: Q6DJL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Cytoplasm
messages: Nucleus

8355:LOC108698242
gene id: 8355:LOC108698242
uniprot id: A0A8J0THY5
uniprot id: A0A8J0TJL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

8355:LOC108716297
gene id: 8355:LOC108716297
uniprot id: A0A8J1KR44
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:tpm2.L
gene id: 8355:tpm2.L
uniprot id: A0A8J0UN23
uniprot id: A0A8J0UPE0
uniprot id: A0A974E301
uniprot id: A0A974E3J5
uniprot id: Q7ZYU5
uniprot id: Q91706
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

8355:jag1.L
gene id: 8355:jag1.L
uniprot id: A0A8J0V838
uniprot id: Q90YD2
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

8355:LOC121401499
gene id: 8355:LOC121401499
uniprot id: A0A8J1MLH8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108695752
gene id: 8355:LOC108695752
uniprot id: A0A1L8FJ99
uniprot id: A0A974HBB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

8355:mmp21.L
gene id: 8355:mmp21.L
uniprot id: O93470
names: Cofactor
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 1 zinc ion per subunit.
messages: Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway.
messages: Secreted
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: The precursor is cleaved by a furin endopeptidase.
messages: Transiently expressed during embryo development. Undetected in the blastula stage embryo, induced in gastrula embryo, expressed in neurula embryo, and then down-regulated in pretailbud embryo.

8355:mapkapk3.S
gene id: 8355:mapkapk3.S
uniprot id: A0A1L8GHD7
uniprot id: A0A974D2N4
uniprot id: A0A974HMF4
uniprot id: Q0IHG8
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC108702183
gene id: 8355:LOC108702183
uniprot id: A0A8J0TYA1
uniprot id: A0A8J1LYA8
uniprot id: A0A8J1LYB9
uniprot id: A0A8J1LZK0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

8355:abhd3.L
gene id: 8355:abhd3.L
uniprot id: A0A1L8FYM9
uniprot id: A0A974HG57
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

8355:anxa1.2.L
gene id: 8355:anxa1.2.L
uniprot id: Q6DKC4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Cytoplasm
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: cilium

8355:LOC108712725
gene id: 8355:LOC108712725
uniprot id: A0A8J1MRH5
names: Similarity
messages: Belongs to the peptidase C14A family.

8355:mtif3.L
gene id: 8355:mtif3.L
uniprot id: A0A1L8HJ65
uniprot id: A0A974DS86
names: Similarity
messages: Belongs to the IF-3 family.

8355:LOC108718877
gene id: 8355:LOC108718877
uniprot id: A0A8J1KX89
names: Subcellular Location Annotation
messages: Membrane

8355:atp5f1d.L
gene id: 8355:atp5f1d.L
uniprot id: Q66KY9
names: Similarity
messages: Belongs to the ATPase epsilon chain family.

8355:LOC108710446
gene id: 8355:LOC108710446
uniprot id: A0A8J1MJP5
names: Subcellular Location Annotation
messages: Membrane

8355:foxf2.L
gene id: 8355:foxf2.L
uniprot id: A0A1L8FXQ3
names: Subcellular Location Annotation
messages: Nucleus

8355:ran.S
gene id: 8355:ran.S
uniprot id: A0A974I1X2
uniprot id: P52301
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Ran family.
messages: Cytoplasm
messages: Detected throughout embryonic development (PubMed:11180838). Detected within the animal pole region at the four-cell stage, then in the anterior neural plate at the neurula stage, and within the head region including the otic vesicles, branchial arches, and the tail region at the tailbud stage (PubMed:11180838, PubMed:25946333).
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
messages: GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:8413630). Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (By similarity). RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation (PubMed:10408446). Required for normal progress through mitosis (By similarity). In concert with nemp1a/b, required for proper eye development (PubMed:25946333).
messages: Mg(2+) interacts primarily with the phosphate groups of the bound guanine nucleotide.
messages: Monomer. Interacts with rangap1, which promotes ran-mediated GTP hydrolysis. Interacts with kpnb1. Interaction with kpnb1 inhibits rangap1-mediated stimulation of GTPase activity. Interacts with rcc1 which promotes the exchange of ran-bound GDP by GTP. Interaction with kpnb1 inhibits rcc1-mediated exchange of ran-bound GDP by GTP. Interacts (GTP-bound form) with tnpo1; the interaction is direct. Interacts (GTP-bound form) with tnpo3; the interaction is direct. Interacts with kpnb1 and with tnpo1; both inhibit ran GTPase activity. Interacts (via C-terminus) with ranbp1, which alleviates the inhibition of ran GTPase activity. Interacts with rangrf, which promotes the release of bound guanine nucleotide. Rangrf and rcc1 compete for an overlapping binding site on ran. Identified in a complex with kpna2 and cse1l; interaction with ranbp1 mediates dissociation of ran from this complex. Interaction with both ranbp1 and kpna2 promotes dissociation of the complex between ran and kpnb1. Identified in a complex composed of ran, rangap1 and ranbp1. Identified in a complex that contains tnpo1, ran and ranbp1. Identified in a nuclear export complex with xpo1. Interaction with ranbp1 or ranbp2 induces a conformation change in the complex formed by xpo1 and ran that triggers the release of the nuclear export signal of cargo proteins. Component of a nuclear export receptor complex composed of kpnb1, ran, snupn and xpo1 (By similarity). Interacts with nemp1a and nemp1b (PubMed:25946333).
messages: Morpholino knockdown results in defects in eye development and reduction of cell density at the neurula stage. Co-knockdown of nemp1a/b and ran elicits reduction of cell density and eye defects more significantly than the individual knockdown of either one.
messages: Nucleus
messages: Nucleus envelope
messages: cytosol

8355:LOC108714626
gene id: 8355:LOC108714626
uniprot id: A0A1L8GPK8
uniprot id: A0A974HQ29
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

8355:plcg1.L
gene id: 8355:plcg1.L
uniprot id: A0A1L8EU11
uniprot id: A0A974BXU0
uniprot id: Q6NTX2
names: Function
messages: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

8355:casp3.2.L
gene id: 8355:casp3.2.L
uniprot id: A0A8J0UPK1
uniprot id: A1L2P4
names: Similarity
messages: Belongs to the peptidase C14A family.

8355:creld2.L
gene id: 8355:creld2.L
uniprot id: A0A974HT85
uniprot id: Q4V7M2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRELD family.
messages: Endoplasmic reticulum
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Possible role in neuronal acetylcholine receptor transport.
messages: Secreted

8355:dipk1b.L
gene id: 8355:dipk1b.L
uniprot id: A0A1L8F645
uniprot id: A0A8J1LGX3
uniprot id: A0A974H6V2
names: Similarity
messages: Belongs to the DIPK family.

8355:LOC108696474
gene id: 8355:LOC108696474
uniprot id: A0A8J0T2A2
uniprot id: A0A8J0TAU8
uniprot id: A0A8J1L9C3
names: Similarity
messages: Belongs to the FAM154 family.

8355:LOC121397079
gene id: 8355:LOC121397079
uniprot id: A0A8J1LIN1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

8355:LOC108702366
gene id: 8355:LOC108702366
uniprot id: A0A1L8EL15
uniprot id: A0A974BSX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8355:piwil4.S
gene id: 8355:piwil4.S
uniprot id: A0A1L8HAX6
names: Similarity
messages: Belongs to the argonaute family.

8355:LOC121401507
gene id: 8355:LOC121401507
uniprot id: A0A8J1MLS4
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:shisa2.L
gene id: 8355:shisa2.L
uniprot id: Q2WFL8
names: Developmental Stage
names: Function
names: Miscellaneous
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 'Shisa' was named after a sculpture form, common to southern Japan, with a large head similar to the Egyptian sphinx.
messages: At late gastrula/early neurula stages expression is restricted to two stripes in the dorsal side but excluded from the dorsal midline. As somitogenesis commences, expression is localized to the paraxial region, lateral to the involuting neural tube. As development proceeds, expressied forming somites. Expression is stronger in the presomitic mesoderm and decreases as somites are formed.
messages: Belongs to the shisa family.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Endoplasmic reticulum membrane
messages: Interacts with fzd8 and fgfr1.
messages: Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both fgf and wnt signaling. Inhibits both wnt and fgf signaling through the regulation of protein maturation and cell surface transportation of their receptors within the endoplasmic reticulum.

8355:LOC108715486
gene id: 8355:LOC108715486
uniprot id: A0A1L8GF47
uniprot id: A0A974HLG2
names: Similarity
messages: Belongs to the UPF0547 family.

8355:MGC85536
gene id: 8355:MGC85536
uniprot id: Q6GM74
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-5, Lys-8 and Lys-12 when associated with the 5'-end of active genes.
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AZ2 forms a heterodimer with H2B (By similarity).
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity).

8355:LOC108710247
gene id: 8355:LOC108710247
uniprot id: A0A8J1MKE5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.

8355:LOC108710681
gene id: 8355:LOC108710681
uniprot id: A0A1L8H4L3
uniprot id: A0A974HUS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108699331
gene id: 8355:LOC108699331
uniprot id: A0A1L8FBS1
uniprot id: A0A974H8R7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108716287
gene id: 8355:LOC108716287
uniprot id: A0A8J0V934
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8355:rad1.L
gene id: 8355:rad1.L
uniprot id: A0A1L8I2M6
uniprot id: A0A8J0U0T0
uniprot id: A0A974E2H5
uniprot id: Q8AY27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

8355:st6gal2.S
gene id: 8355:st6gal2.S
uniprot id: A0A1L8H8L4
uniprot id: A0A974DI41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8355:marchf2.S
gene id: 8355:marchf2.S
uniprot id: Q5PQ35
names: Domain
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Lysosome membrane
messages: The RING-CH-type zinc finger domain is required for E3 ligase activity.

8355:jph4.S
gene id: 8355:jph4.S
uniprot id: A0A1L8HPJ4
uniprot id: A0A974DU38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:LOC108704863
gene id: 8355:LOC108704863
uniprot id: A0A8J0U5M7
names: Subcellular Location Annotation
messages: Nucleus

8355:pheta1.L
gene id: 8355:pheta1.L
uniprot id: A0A1L8I1V8
uniprot id: A0A974E2Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sesquipedalian family.
messages: Early endosome
messages: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
messages: Recycling endosome
messages: clathrin-coated vesicle
messages: trans-Golgi network

8355:unc5b.S
gene id: 8355:unc5b.S
uniprot id: A0A8J0TAL5
uniprot id: A0A8J1LC88
uniprot id: C5IAW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Interacts (via extracellular domain) with flrt3 (via extracellular domain). Interacts with rnd1.
messages: Membrane
messages: Plays a role in cell-cell adhesion during embryonic development (PubMed:19492039). Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity).
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

8355:LOC108719696
gene id: 8355:LOC108719696
uniprot id: A0A8J1L4J2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: paranodal septate junction

8355:mycbp.S
gene id: 8355:mycbp.S
uniprot id: A0A8J0U589
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AMY1 family.
messages: Nucleus

8355:LOC108708781
gene id: 8355:LOC108708781
uniprot id: A0A8J1MAF1
uniprot id: A0A8J1MBF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8355:tmem87b.L
gene id: 8355:tmem87b.L
uniprot id: A0A1L8G7A8
uniprot id: A0A974CU17
names: Subcellular Location Annotation
messages: Membrane

8355:kcns1.S
gene id: 8355:kcns1.S
uniprot id: A0A1L8EKU1
names: Subcellular Location Annotation
messages: Membrane

8355:foxd4l1.1.S
gene id: 8355:foxd4l1.1.S
uniprot id: A0A974DUQ2
uniprot id: B7ZQ25
uniprot id: Q9PRJ8
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed both maternally and zygotically. First expressed at stage II of oogenesis. Maternal expression levels are low and become further reduced after fertilization. Zygotic expression begins at the mid-blastula transition and peaks during the gastrula/neurula stages. A lower level of expression is then maintained during tailbud and later stages.
messages: Maternal expression is localized to the animal hemisphere of the cleavage embryo. In pre-gastrula embryos, zygotic expression begins in the presumptive neural ectoderm. During gastrulation, expression is confined to the superficial layer of cells in the dorsal blastopore lip (Spemann organizer). Also expressed at a lower level in the paraxial mesoderm but not in the notochord. Expression is subsequently lost until after neural tube closure when expression re-initiates in the tailtip within the entire neural tube and paraxial mesoderm, but not in the notochord.
messages: Nucleus
messages: Strongly by siamois, moderately by cer1 and weakly by wnt8 and nog.
messages: Transcriptional repressor with a role in dorsal axis formation and neural plate expansion; maintains an undifferentiated neural ectoderm after neural induction.

8355:tspan6.L
gene id: 8355:tspan6.L
uniprot id: A0A1L8F7H3
uniprot id: A0A974C6P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8355:LOC108699124
gene id: 8355:LOC108699124
uniprot id: A0A1L8FCF1
uniprot id: A0A8J1LJ07
uniprot id: A0A8J1LLC2
names: Similarity
messages: Belongs to the MHC class I family.

8355:stx4.L
gene id: 8355:stx4.L
uniprot id: Q32NP4
names: Similarity
messages: Belongs to the syntaxin family.

8355:adm.S
gene id: 8355:adm.S
uniprot id: A0A1L8GDP1
uniprot id: A0A974HL12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adrenomedullin family.
messages: Secreted

8355:samd4a.S
gene id: 8355:samd4a.S
uniprot id: Q5FWP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a translational repressor.
messages: Belongs to the SMAUG family.
messages: Cytoplasm
messages: dendrite
messages: synaptosome

8355:h4c1.L
gene id: 8355:h4c1.L
uniprot id: A0A1L8G0S8
uniprot id: A0A974HGS3
uniprot id: P62799
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by pak2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

8355:hoxa9.S
gene id: 8355:hoxa9.S
uniprot id: A0A974CIX2
uniprot id: A2BD86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

8355:amer3.L
gene id: 8355:amer3.L
uniprot id: A0A1L8GAV5
uniprot id: A0A8J1KPZ4
uniprot id: A0A974HK62
names: Similarity
messages: Belongs to the Amer family.

8355:irf9.S
gene id: 8355:irf9.S
uniprot id: A0A1L8HPG8
uniprot id: A0A8J0U8L4
uniprot id: A0A974I1B0
names: Subcellular Location Annotation
messages: Nucleus

8355:arrdc4.L
gene id: 8355:arrdc4.L
uniprot id: A0A1L8H111
uniprot id: A0A974HTR4
names: Similarity
messages: Belongs to the arrestin family.

8355:bace2.S
gene id: 8355:bace2.S
uniprot id: A0A974DH44
uniprot id: Q6PB20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Endosome
messages: Membrane

8355:napsa.L
gene id: 8355:napsa.L
uniprot id: Q6P7F8
names: Similarity
messages: Belongs to the peptidase A1 family.

8355:nxn.L
gene id: 8355:nxn.L
uniprot id: A0A1L8HG37
uniprot id: A0A974HYY9
names: Similarity
messages: Belongs to the nucleoredoxin family.

8355:fermt2.S
gene id: 8355:fermt2.S
uniprot id: A0A8J0TP80
uniprot id: A0A8J0TQA2
uniprot id: A0A8J1LPI2
uniprot id: A0A8J1LPR1
uniprot id: A0A8J1LQX0
names: Similarity
messages: Belongs to the kindlin family.

8355:ski.L
gene id: 8355:ski.L
uniprot id: A0A1L8FM01
uniprot id: A0A974CI77
uniprot id: P87388
names: Similarity
messages: Belongs to the SKI family.

8355:cldn10.L
gene id: 8355:cldn10.L
uniprot id: A0A1L8HHA5
uniprot id: A0A974DQ19
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8355:tnf.S
gene id: 8355:tnf.S
uniprot id: A0A1L8F3P0
uniprot id: A0A974C466
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8355:parp11.L
gene id: 8355:parp11.L
uniprot id: A0A1L8GWH3
uniprot id: A0A8J1MJC2
uniprot id: A0A974DBC5
uniprot id: Q5PQ88
names: Similarity
messages: Belongs to the ARTD/PARP family.

8355:klhl21.L
gene id: 8355:klhl21.L
uniprot id: A0A974HCF4
uniprot id: Q5U575
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the BCR(KLHL21) E3 ubiquitin ligase complex, at least composed of cul3, klhl21 and rbx1.
messages: Substrate-specific adapter of BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB (By similarity).
messages: spindle

8355:gpr52.L
gene id: 8355:gpr52.L
uniprot id: A0A1L8GMI0
uniprot id: A0A974D6E2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:psph.S
gene id: 8355:psph.S
uniprot id: A0A1L8H876
uniprot id: A0A974HVV7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

8355:LOC121396917
gene id: 8355:LOC121396917
uniprot id: A0A8J1LG23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEAP2 family.
messages: Has an antimicrobial activity.
messages: Secreted

8355:mex3c.S
gene id: 8355:mex3c.S
uniprot id: A1A5I7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:xenoxin1.L
gene id: 8355:xenoxin1.L
uniprot id: Q09022
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed by the skin dorsal glands.
messages: Lacks alpha-neurotoxic activity, has apparently no antibacterial activity, nor anti-coagulant potency.
messages: Secreted

8355:plcd4.L
gene id: 8355:plcd4.L
uniprot id: Q32NH8
names: Cofactor
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Binds 5 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores (By similarity).
messages: Membrane
messages: Nucleus
messages: The GBA (G-alpha binding and activating) motif mediates binding to the alpha subunits of guanine nucleotide-binding proteins (G proteins).

8355:MGC64389
gene id: 8355:MGC64389
uniprot id: A0A8J0U6T3
uniprot id: Q7SZ93
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8355:pggt1b.L
gene id: 8355:pggt1b.L
uniprot id: A0A1L8I1K8
uniprot id: A0A974E2E4
uniprot id: Q6NTZ4
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

8355:LOC108698694
gene id: 8355:LOC108698694
uniprot id: A0A8J0TBU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8355:dynlt2b.S
gene id: 8355:dynlt2b.S
uniprot id: A0A8J0VG06
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

8355:smad3.L
gene id: 8355:smad3.L
uniprot id: A0A974DFB0
uniprot id: Q90YE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

8355:tarbp2.L
gene id: 8355:tarbp2.L
uniprot id: A0A8J0U3U1
uniprot id: Q6GPZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TARBP2 family.
messages: Cytoplasm
messages: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.
messages: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of dicer1, ago2 and tarbp2. Within the RLC/miRLC, dicer1 and tarbp2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto ago2. ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from dicer1 and tarbp2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by dicer1.
messages: Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC.
messages: Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of dicer1, ago2 and tarbp2. Note that the trimeric RLC/miRLC is also referred to as RISC.

8355:LOC108712708
gene id: 8355:LOC108712708
uniprot id: A0A1L8GRP8
uniprot id: A0A974HQF8
names: Subcellular Location Annotation
messages: Membrane

8355:agtrap.L
gene id: 8355:agtrap.L
uniprot id: A0A8J1L7E5
uniprot id: Q4V7T6
names: Subcellular Location Annotation
messages: Membrane

8355:kcnn3.S
gene id: 8355:kcnn3.S
uniprot id: A0A1L8F514
uniprot id: A0A974H6G3
names: Subcellular Location Annotation
messages: Membrane

8355:scube2.S
gene id: 8355:scube2.S
uniprot id: A0A1L8GEE5
uniprot id: A0A8J0V1D1
uniprot id: A0A8J0V5U4
uniprot id: A0A8J1KHY6
uniprot id: A0A8J1KI00
uniprot id: A0A8J1KJS0
uniprot id: A0A974HLK8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:ppm1b.L
gene id: 8355:ppm1b.L
uniprot id: A0A1L8G6L5
uniprot id: A0A8J0V890
uniprot id: A0A8J1KN12
uniprot id: A0A974CTD1
uniprot id: Q6GR26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

8355:LOC121396046
gene id: 8355:LOC121396046
uniprot id: A0A8J1LD39
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:gars1.L
gene id: 8355:gars1.L
uniprot id: Q6DEA1
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Homodimer.

8355:smad6.2.L
gene id: 8355:smad6.2.L
uniprot id: A0A1L8FDC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

8355:lin7c.2.L
gene id: 8355:lin7c.2.L
uniprot id: A0A8J0UZE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-7 family.
messages: Cell junction
messages: Cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.

8355:copz2.L
gene id: 8355:copz2.L
uniprot id: A0A8J0TV27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

8355:ubtd2.S
gene id: 8355:ubtd2.S
uniprot id: Q640W6
names: Function
messages: May be involved in the regulation of cellular senescence through a positive feedback loop with TP53.

8355:LOC108707477
gene id: 8355:LOC108707477
uniprot id: A0A8J0UCR6
names: Subcellular Location Annotation
messages: Nucleus

8355:xpo1.S
gene id: 8355:xpo1.S
uniprot id: A0A974CPW3
uniprot id: Q6NS03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

8355:XB5957215.L
gene id: 8355:XB5957215.L
uniprot id: A0A1L8HV37
uniprot id: A0A8J1MLR5
uniprot id: A0A974I358
uniprot id: A0A974I3G3
uniprot id: B7ZQ22
uniprot id: O57422
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Cell membrane
messages: Highest level in the iris, high level in the inner nuclear layer, possibly in horizontal cells, and lowest level in retinal pigment epithelium. Expressed in melanophore cells of the skin.
messages: Membrane
messages: Photoreceptor implicated in non-image-forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal (By similarity).

8355:slc49a4.L
gene id: 8355:slc49a4.L
uniprot id: A0A974BYX2
uniprot id: Q6GNV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Lysosome membrane
messages: Mediates H(+)-dependent pyridoxine transport.
messages: Membrane

8355:elovl1.S
gene id: 8355:elovl1.S
uniprot id: A0A974HM44
uniprot id: Q8AVG1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL1 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

8355:LOC121393160
gene id: 8355:LOC121393160
uniprot id: A0A8J1KKM6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:pigo.L
gene id: 8355:pigo.L
uniprot id: A0A8J1M3B3
uniprot id: Q6GNZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:tnfsf11.L
gene id: 8355:tnfsf11.L
uniprot id: A0A1L8HHK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Membrane
messages: Secreted

8355:LOC108715803
gene id: 8355:LOC108715803
uniprot id: A0A1L8I029
uniprot id: A0A974E0W2
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:dut.S
gene id: 8355:dut.S
uniprot id: A0A8J0V087
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

8355:fnbp1l.S
gene id: 8355:fnbp1l.S
uniprot id: A0A1L8GG92
uniprot id: A0A8J0UZX2
uniprot id: A0A8J1MZG6
uniprot id: A0A8J1N1F0
uniprot id: A0A8J1N273
uniprot id: A0A974HLS9
uniprot id: Q6DCZ7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FNBP1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures (By similarity). Interacts with GTP-bound cdc42 and wasl/n-wasp.
messages: Membrane
messages: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Essential for autophagy of intracellular bacterial pathogens (By similarity). Promotes cdc42-induced actin polymerization by activating the wasl-waspip complex, the predominant form of wasl/n-wasp in cells.
messages: The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation (By similarity).
messages: Vesicle
messages: cell cortex
messages: cytoskeleton

8355:LOC108718478
gene id: 8355:LOC108718478
uniprot id: A0A1L8FVR9
uniprot id: A0A974CN51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

8355:LOC108705452
gene id: 8355:LOC108705452
uniprot id: A0A8J0U685
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8355:LOC121403704
gene id: 8355:LOC121403704
uniprot id: A0A8J1N087
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:etfb.L
gene id: 8355:etfb.L
uniprot id: Q6PBB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF beta-subunit/FixA family.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

8355:ppp2r5e.S
gene id: 8355:ppp2r5e.S
uniprot id: A0A1L8F007
uniprot id: A0A8J0TLC5
uniprot id: A0A974C1K9
uniprot id: A0A974C1R0
uniprot id: Q5XH34
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.

8355:myo5a.L
gene id: 8355:myo5a.L
uniprot id: A0A8J0QHU3
uniprot id: A0A8J1MGQ3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8355:lsf
gene id: 8355:lsf
uniprot id: A0A8J1MB92
uniprot id: Q7T0B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

8355:agt.S
gene id: 8355:agt.S
uniprot id: A0A1L8G2D7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family.
messages: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
messages: Secreted
messages: Stimulates aldosterone release.

8355:kdm6b.S
gene id: 8355:kdm6b.S
uniprot id: A0A8J0U3C5
uniprot id: A0A8J1MT01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTX family.
messages: Nucleus

8355:LOC108710235
gene id: 8355:LOC108710235
uniprot id: A0A1L8GXN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

8355:mrps15.L
gene id: 8355:mrps15.L
uniprot id: A0A1L8HFJ1
uniprot id: A0A974HYG7
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

8355:LOC108701783
gene id: 8355:LOC108701783
uniprot id: A0A8J1LXD0
names: Subcellular Location Annotation
messages: Membrane

8355:skap1.S
gene id: 8355:skap1.S
uniprot id: A0A1L8EKS0
uniprot id: A0A974BSC1
names: Similarity
messages: Belongs to the SKAP family.

8355:kdelr2.L
gene id: 8355:kdelr2.L
uniprot id: A0A974C0K8
uniprot id: Q7ZXS5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: Binds the C-terminal sequence motif K-D-E-L in a hydrophilic cavity between the transmembrane domains. This triggers a conformation change that exposes a Lys-rich patch on the cytosolic surface of the protein (By similarity). This patch mediates recycling from the Golgi to the endoplasmic reticulum, probably via COPI vesicles (By similarity).
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum (By similarity). Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity).

8355:tmem107.L
gene id: 8355:tmem107.L
uniprot id: A0A8J1MI86
uniprot id: Q3B8H0
names: Function
names: Subcellular Location Annotation
messages: May play a role in cilia formation and embryonic patterning.
messages: Membrane

8355:LOC108707464
gene id: 8355:LOC108707464
uniprot id: A0A1L8HDX3
uniprot id: A0A974DMA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:prickle3.L
gene id: 8355:prickle3.L
uniprot id: A0A8J1LFW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prickle / espinas / testin family.
messages: Cell membrane
messages: Membrane

8355:nme5.L
gene id: 8355:nme5.L
uniprot id: A0A1L8GXA0
uniprot id: A0A974DAM0
uniprot id: Q66IR2
names: Similarity
messages: Belongs to the NDK family.

8355:barx1.L
gene id: 8355:barx1.L
uniprot id: A0A8J0U6G7
names: Subcellular Location Annotation
messages: Nucleus

8355:trim36.L
gene id: 8355:trim36.L
uniprot id: A0A8J0U871
uniprot id: A0A8J1LYY1
uniprot id: A0A8J1M030
uniprot id: Q6NU77
names: Subcellular Location Annotation
messages: cytoskeleton

8355:LOC121395584
gene id: 8355:LOC121395584
uniprot id: A0A8J1L719
uniprot id: A0A8J1L729
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0688 family.
messages: Nucleus

8355:LOC108695723
gene id: 8355:LOC108695723
uniprot id: A0A1L8FIK2
uniprot id: A0A974HB76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108702827
gene id: 8355:LOC108702827
uniprot id: A0A8J0U128
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8355:LOC108705918
gene id: 8355:LOC108705918
uniprot id: A0A8J1KZB2
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:slc45a4.L
gene id: 8355:slc45a4.L
uniprot id: A0A1L8G036
uniprot id: A0A974CPF9
names: Subcellular Location Annotation
messages: Membrane

8355:mocs2.L
gene id: 8355:mocs2.L
uniprot id: A0A8J1L9K6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MoaE family. MOCS2B subfamily.
messages: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
messages: This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2A).
messages: cytosol

8355:XB980013.L
gene id: 8355:XB980013.L
uniprot id: A2VD77
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:LOC121393074
gene id: 8355:LOC121393074
uniprot id: A0A1L8G680
uniprot id: A0A8J1KMA9
uniprot id: A0A974CU41
names: Subcellular Location Annotation
messages: Membrane

8355:psmd2.S
gene id: 8355:psmd2.S
uniprot id: Q4KLW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S2 family.
messages: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

8355:hmgn3.S
gene id: 8355:hmgn3.S
uniprot id: A0A8J0VA22
uniprot id: A0A8J0VCY2
uniprot id: A0A8J0VDC7
uniprot id: Q7SZC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

8355:papolg.L
gene id: 8355:papolg.L
uniprot id: A0A8J0V9D4
uniprot id: A0A8J0VE76
uniprot id: Q3I527
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Nucleus

8355:LOC121401270
gene id: 8355:LOC121401270
uniprot id: A0A8J1MJH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:ing2.S
gene id: 8355:ing2.S
uniprot id: A0A974I0I3
uniprot id: Q0IHB1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

8355:psmd4.L
gene id: 8355:psmd4.L
uniprot id: A0A1L8FDD6
uniprot id: A0A974CAC0
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

8355:trnau1ap.S
gene id: 8355:trnau1ap.S
uniprot id: Q7T0M5
names: Similarity
messages: Belongs to the RRM TRSPAP family.

8355:tjap1.S
gene id: 8355:tjap1.S
uniprot id: A0A1L8G0Y8
uniprot id: A0A8J1KS49
uniprot id: A0A974CQP5
names: Subcellular Location Annotation
messages: Membrane

8355:farsb.S
gene id: 8355:farsb.S
uniprot id: A0A8J1KRW3
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

8355:fermt1.L
gene id: 8355:fermt1.L
uniprot id: A0A1L8G602
uniprot id: A0A8J0VEQ5
uniprot id: A0A974CV06
names: Similarity
messages: Belongs to the kindlin family.

8355:lrp1.L
gene id: 8355:lrp1.L
uniprot id: A0A8J0UGQ9
names: Caution
names: Similarity
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:brk1.L
gene id: 8355:brk1.L
uniprot id: Q6P7G6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRK1 family.
messages: Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex (By similarity).
messages: cytoskeleton

8355:serpinc1.L
gene id: 8355:serpinc1.L
uniprot id: Q8UVS0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the serpin family.
messages: Forms protease inhibiting heterodimer with TMPRSS7.
messages: extracellular space

8355:sbk1l.S
gene id: 8355:sbk1l.S
uniprot id: A0A1L8G593
uniprot id: A0A974CUK6
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:senp8.L
gene id: 8355:senp8.L
uniprot id: A0A974DCN6
uniprot id: Q5FWL6
names: Similarity
messages: Belongs to the peptidase C48 family.

8355:caprin1.S
gene id: 8355:caprin1.S
uniprot id: A0A8J0UZC6
uniprot id: A0A8J0V3B9
uniprot id: A0A8J0V3C4
uniprot id: A0A8J0V457
uniprot id: A0A8J0V4L4
uniprot id: A0A8J0V8I9
uniprot id: Q75T15
names: Similarity
messages: Belongs to the caprin family.

8355:hoxd3.L
gene id: 8355:hoxd3.L
uniprot id: A1L2P5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: It is uncertain whether Met-1 or Met-17 is the initiator.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

8355:ca7.S
gene id: 8355:ca7.S
uniprot id: A0A8J0U3A5
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

8355:uqcr10.S
gene id: 8355:uqcr10.S
uniprot id: A0A974DUC4
uniprot id: A9UM09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

8355:mycl.S
gene id: 8355:mycl.S
uniprot id: A0A310UE58
uniprot id: A0A974H075
uniprot id: Q7ZYN1
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

8355:pdlim3.S
gene id: 8355:pdlim3.S
uniprot id: A0A8J0U8F5
uniprot id: A0A8J0UAS0
names: Subcellular Location Annotation
messages: Z line

8355:csnk1g3.S
gene id: 8355:csnk1g3.S
uniprot id: A0A974I1L0
uniprot id: Q5EAV0
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

8355:me1.L
gene id: 8355:me1.L
uniprot id: A0A1L8G977
uniprot id: A0A8J1KNT4
uniprot id: A0A974HJN9
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

8355:zdhhc5.L
gene id: 8355:zdhhc5.L
uniprot id: A0A1L8FKK0
uniprot id: A0A8J1L5Z5
uniprot id: A0A974HBT1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:gtf2f1.L
gene id: 8355:gtf2f1.L
uniprot id: A0A8J0UNA9
uniprot id: A0A974DEV9
uniprot id: Q04870
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIF alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit.
messages: Nucleus
messages: Phosphorylated on Ser and other residues by TAF1 and casein kinase II-like kinases.
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.

8355:f10.L
gene id: 8355:f10.L
uniprot id: A0A974DNT6
uniprot id: Q6PAG2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:twsg1.S
gene id: 8355:twsg1.S
uniprot id: A0A1L8FSP6
uniprot id: A0A974CJJ2
uniprot id: Q98T88
names: Developmental Stage
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the twisted gastrulation protein family.
messages: Binds directly to bmp2, bmp4 and bmp7 and can form a ternary complex with bmps and chordin, thus preventing the binding of bmps to their cell surface receptors.
messages: Involved in dorsal-ventral patterning, permitting peak BMP signaling by antagonizing the residual anti-BMP activity of the cleavage products of chrd. Functions to promote the formation of ventral mesoderm by increasing the activity of bmp7 and other BMPS. Seems to antagonize BMP signaling by forming ternary complexes with chrd and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of chrd, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation (By similarity).
messages: Knockdown of tsg and bmp7 results in the siren phenotype with loss of posteroventral cell fates associated with decreased BMP activity.
messages: Maternal transcripts detected in eggs. Uniform expression across the entire animal hemisphere and marginal zone of the early gastrula. At tailbud stage, expressed in the developing tail, anterior brain, eye and heart.
messages: Posterior defects are induced by overexpression. This may arise through alteration of bmp4 or chrd function in the developing tailbud region.
messages: Secreted
messages: The N-terminal domain is sufficient to interact with bmp4.

8355:tmprss2.2.L
gene id: 8355:tmprss2.2.L
uniprot id: A0A1L8HC98
uniprot id: A0A8J1M6X4
uniprot id: A0A8J1M6Y1
uniprot id: A0A8J1M713
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:rgs4.S
gene id: 8355:rgs4.S
uniprot id: A0A1L8GGH1
uniprot id: A0A974D1P8
uniprot id: Q9I9D9
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

8355:cryga.8.S
gene id: 8355:cryga.8.S
uniprot id: A0A8J1LYD7
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:LOC108715519
gene id: 8355:LOC108715519
uniprot id: A0A8J1KIV9
uniprot id: A0A8J1KIX3
uniprot id: A0A8J1KIY0
uniprot id: A0A8J1KIY5
uniprot id: A0A8J1KKL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

8355:LOC108697270
gene id: 8355:LOC108697270
uniprot id: A0A8J1MMC9
uniprot id: A0A8J1MN66
uniprot id: A0A8J1MN71
uniprot id: A0A8J1MNA7
uniprot id: A0A8J1MPC1
uniprot id: A0A8J1MPC6
uniprot id: A0A8J1MPD6
uniprot id: A0A8J1MPE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferlin family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

8355:LOC108705317
gene id: 8355:LOC108705317
uniprot id: A0A8J0U5Z3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108718748
gene id: 8355:LOC108718748
uniprot id: A0A8J1KWR2
uniprot id: A0A8J1KWR9
uniprot id: A0A8J1KWS1
uniprot id: A0A8J1KYD6
names: Similarity
messages: Belongs to the DIP2 family.

8355:atf2.L
gene id: 8355:atf2.L
uniprot id: A0A1L8EWJ3
uniprot id: A0A8J1LQZ1
uniprot id: A0A974H3J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

8355:LOC108698294
gene id: 8355:LOC108698294
uniprot id: A0A1L8F6U0
uniprot id: A0A974C5X3
names: Caution
names: Similarity
messages: Belongs to the peptidase M43B family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:slain2l.S
gene id: 8355:slain2l.S
uniprot id: A0A1L8F356
uniprot id: A0A8J0TNL7
uniprot id: A0A974H5Y2
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

8355:sp8.L
gene id: 8355:sp8.L
uniprot id: Q5XGT8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Sp1 C2H2-type zinc-finger protein family.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity).

8355:LOC121396177
gene id: 8355:LOC121396177
uniprot id: A0A8J1LDE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

8355:LOC108697710
gene id: 8355:LOC108697710
uniprot id: A0A8J0TFS7
uniprot id: A0A8J1LD11
uniprot id: A0A8J1LD30
uniprot id: A0A8J1LDB5
uniprot id: A0A8J1LEK3
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC121402059
gene id: 8355:LOC121402059
uniprot id: A0A8J1MPQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:mthfr.L
gene id: 8355:mthfr.L
uniprot id: Q7ZWU2
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

8355:cyp2c8.1.L
gene id: 8355:cyp2c8.1.L
uniprot id: A0A1L8FB58
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:frrs1.L
gene id: 8355:frrs1.L
uniprot id: A0A1L8GMP7
uniprot id: A0A974HPG3
uniprot id: Q6INU7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRRS1 family.
messages: Binds 2 heme b groups non-covalently.
messages: Membrane
messages: Putative ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm.
messages: The cytochrome b561 domain lacks the conserved His residue that binds iron in the heme. The reductase activity is therefore unsure in vivo.

8355:pabir2.L
gene id: 8355:pabir2.L
uniprot id: A0A1L8F843
uniprot id: A0A8J0TH56
uniprot id: A0A8J0TKI4
uniprot id: A0A8J1LGQ4
uniprot id: A0A8J1LHA4
uniprot id: A0A8J1LHA9
uniprot id: A0A8J1LI42
uniprot id: A0A8J1LJ72
uniprot id: A0A974C6Z7
names: Similarity
messages: Belongs to the FAM122 family.

8355:cdh5.S
gene id: 8355:cdh5.S
uniprot id: A0A1L8GEW5
uniprot id: A0A974D0T1
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane

8355:tube1.L
gene id: 8355:tube1.L
uniprot id: Q8AXK5
names: Similarity
messages: Belongs to the tubulin family.

8355:sco2.S
gene id: 8355:sco2.S
uniprot id: A0A8J0TX57
uniprot id: A9ULZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCO1/2 family.
messages: Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2.
messages: Homodimer.
messages: Mitochondrion inner membrane

8355:rab32.L
gene id: 8355:rab32.L
uniprot id: A0A1L8G7U2
uniprot id: A0A974CUY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

8355:ppp1r14b.S
gene id: 8355:ppp1r14b.S
uniprot id: A0A974HKQ6
uniprot id: Q0IHD5
names: Similarity
messages: Belongs to the PP1 inhibitor family.

8355:dmrt2.L
gene id: 8355:dmrt2.L
uniprot id: Q3KQ27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

8355:mycl.L
gene id: 8355:mycl.L
uniprot id: A0A1L8HFT7
uniprot id: A0A8J1M566
uniprot id: Q05404
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.
messages: High levels in oocytes, modest levels in kidney and low levels in spleen.
messages: Nucleus

8355:hacd2.L
gene id: 8355:hacd2.L
uniprot id: A0A8J1LS93
uniprot id: A0A974BYJ1
uniprot id: Q6DCE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:LOC108704008
gene id: 8355:LOC108704008
uniprot id: A0A8J1MYG9
uniprot id: A0A8J1MYH5
uniprot id: A0A8J1MYR6
uniprot id: A0A8J1MYS1
uniprot id: A0A8J1MZM0
uniprot id: A0A8J1MZM6
uniprot id: A0A8J1N093
uniprot id: A0A8J1N099
uniprot id: A0A8J1N114
uniprot id: A0A8J1N122
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

8355:dpy30.S
gene id: 8355:dpy30.S
uniprot id: A0A974CQY9
uniprot id: Q6GQK3
names: Similarity
messages: Belongs to the dpy-30 family.

8355:inhba.S
gene id: 8355:inhba.S
uniprot id: A0A1L8FRS5
uniprot id: A0A974CIY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

8355:tuba1cl.3.S
gene id: 8355:tuba1cl.3.S
uniprot id: A0A1L8ENS7
uniprot id: A0A8J1LYZ1
uniprot id: A0A974H145
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

8355:osbpl3.S
gene id: 8355:osbpl3.S
uniprot id: A0A1L8FR93
uniprot id: A0A8J0VM41
uniprot id: A0A8J0VQA2
uniprot id: A0A974CIP2
names: Similarity
messages: Belongs to the OSBP family.

8355:fam199x.L
gene id: 8355:fam199x.L
uniprot id: Q6GP60
names: Similarity
messages: Belongs to the FAM199 family.

8355:rce1.S
gene id: 8355:rce1.S
uniprot id: A0A1L8GD49
uniprot id: A0A974CZS7
uniprot id: Q6GM63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U48 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:bix1.3.S
gene id: 8355:bix1.3.S
uniprot id: A0A974HGV4
uniprot id: B7ZQT2
uniprot id: O93536
names: Subcellular Location Annotation
messages: Nucleus

8355:ucn3.L
gene id: 8355:ucn3.L
uniprot id: A0A1L8GZJ0
uniprot id: A0A974HT40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

8355:LOC108718510
gene id: 8355:LOC108718510
uniprot id: A0A8J1KXS7
uniprot id: A0A8J1KXT0
uniprot id: A0A8J1KXT1
uniprot id: A0A8J1KXT2
uniprot id: A0A8J1KXT5
uniprot id: A0A8J1KXT6
uniprot id: A0A8J1KZE5
uniprot id: A0A8J1KZF0
uniprot id: A0A8J1L0Q1
uniprot id: A0A8J1L0Q5
names: Similarity
messages: Belongs to the beta-catenin family.

8355:clspn.S
gene id: 8355:clspn.S
uniprot id: A0A8J0UGM6
uniprot id: A0A8J0UHY4
uniprot id: Q9DF50
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the claspin family.
messages: Interacts with both chek1 and plk1/plx1 when phosphorylated.
messages: Nucleus
messages: Phosphorylated. Phosphorylation at Ser-864, Ser-895 and Thr-906 occurs during checkpoint activation and requires the ATR kinase. Phosphorylation at Ser-864 within CKB motif 1 and Ser-895 within CKB motif 2 promotes interaction with the catalytic domain of chek1 and subsequent activation of the kinase. Phosphorylation at Thr-906 creates a binding site for the Polo-box domain of the plk1/plx1 kinase, which subsequently phosphorylates Ser-934. Phosphorylation of Ser-934 is required for chek1 inactivation during checkpoint adaptation, the process whereby a prolonged cell cycle arrest is alleviated without prior removal of the checkpoint-inducing DNA lesion. Checkpoint adaptation may promote cellular proliferation when non-lethal DNA damage cannot be repaired in a timely manner.
messages: Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by UV irradiation. Adapter protein which binds to the checkpoint kinase chek1 and facilitates the phosphorylation and activation of this kinase by the ATR-TREX1/ATRIP kinase complex. Also associates with chromatin during S-phase, and this requires the pre-replication complex (pre-RC), cdc45 and cdk2. This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks.
messages: The CHEK1-binding domain (CKBD) contains 2 potential CHEK1-binding motifs (CKB motifs). Phosphorylation sites within CKB motif 1 and CKB motif 2 are required for interaction with CHEK1.

8355:rpl29.S
gene id: 8355:rpl29.S
uniprot id: A0A974D2P7
uniprot id: Q66KW1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

8355:ophn1.L
gene id: 8355:ophn1.L
uniprot id: A0A8J0TWZ8
uniprot id: Q6PCK6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Postsynapse
messages: Presynapse
messages: dendrite

8355:wnt1.L
gene id: 8355:wnt1.L
uniprot id: P10108
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: At neurula in anterior neural fold; at tailbud in dorsal midline of midbrain.
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (By similarity). Plays an important role in patterning during embryonic development (PubMed:2673541). Plays an essential role in the development of the embryonic brain and central nervous system (CNS) (By similarity). Has a role in osteoblast function, bone development and bone homeostasis (By similarity).
messages: Neurula onwards.
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Palmitoleoylation is necessary for proper trafficking to cell surface (By similarity). Depalmitoleoylated by NOTUM, leading to inhibit Wnt signaling pathway (By similarity).
messages: Secreted
messages: extracellular matrix

8355:brk1.S
gene id: 8355:brk1.S
uniprot id: A0A974D329
uniprot id: A2BD66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRK1 family.
messages: Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex (By similarity).
messages: cytoskeleton

8355:fgfbp1.S
gene id: 8355:fgfbp1.S
uniprot id: Q640W8
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

8355:LOC108703994
gene id: 8355:LOC108703994
uniprot id: A0A8J1M2J2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC121399983
gene id: 8355:LOC121399983
uniprot id: A0A1L8HEZ8
names: Similarity
messages: Belongs to the TAFA family.

8355:LOC108719302
gene id: 8355:LOC108719302
uniprot id: A0A1L8FZ87
uniprot id: A0A8J1L1K7
uniprot id: A0A974CQQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus

8355:ska3.L
gene id: 8355:ska3.L
uniprot id: B1H1S4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SKA3 family.
messages: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules.
messages: Component of the SKA1 complex, composed of ska1, ska2 and ska3.
messages: kinetochore
messages: spindle

8355:fgfr3.L
gene id: 8355:fgfr3.L
uniprot id: A0A8J1MBZ7
uniprot id: A0A8J1MCC7
uniprot id: A0A8J1MCD4
uniprot id: A0A8J1MCE7
uniprot id: A0A8J1MCZ3
uniprot id: A0A8J1MDS2
uniprot id: A0A8J1MDT6
uniprot id: Q6GNS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

8355:LOC108712451
gene id: 8355:LOC108712451
uniprot id: A0A8J1MRE6
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:uros.L
gene id: 8355:uros.L
uniprot id: A0A1L8FJ62
uniprot id: A0A8J0T6D4
uniprot id: A0A8J0T9I5
uniprot id: A0A8J1L799
uniprot id: A0A974HBP0
uniprot id: Q66KP4
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.

8355:LOC108711333
gene id: 8355:LOC108711333
uniprot id: A0A8J0URZ3
uniprot id: A0A8J0UVB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

8355:LOC108695329
gene id: 8355:LOC108695329
uniprot id: A0A1L8FT76
uniprot id: A0A8J1L5I5
uniprot id: A0A974HEA1
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

8355:LOC108707771
gene id: 8355:LOC108707771
uniprot id: A0A8J0U4X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:wnk1.L
gene id: 8355:wnk1.L
uniprot id: A0A8J1MJE6
uniprot id: A0A8J1MJF3
uniprot id: A0A8J1MJG0
uniprot id: A0A8J1MJG6
uniprot id: A0A8J1MJH1
uniprot id: A0A8J1MK65
uniprot id: A0A8J1MK70
uniprot id: A0A8J1MK77
uniprot id: A0A8J1MKF4
uniprot id: A0A8J1MKF9
uniprot id: A0A8J1MLG9
uniprot id: A0A8J1MLH4
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

8355:lancl3.S
gene id: 8355:lancl3.S
uniprot id: A0A1L8H8K0
uniprot id: A0A974DI33
names: Similarity
messages: Belongs to the LanC-like protein family.

8355:LOC108712630
gene id: 8355:LOC108712630
uniprot id: A0A8J0UVM1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:mapk10.S
gene id: 8355:mapk10.S
uniprot id: A0A8J1M1W9
uniprot id: A0A8J1M1Y1
uniprot id: A0A8J1M1Z4
uniprot id: A0A8J1M327
uniprot id: A0A8J1M3T8
uniprot id: A0A8J1M3U3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

8355:dnttip1.S
gene id: 8355:dnttip1.S
uniprot id: Q6PCF3
names: Subcellular Location Annotation
messages: Nucleus

8355:b3galt1.L
gene id: 8355:b3galt1.L
uniprot id: A0A1L8EW96
uniprot id: A0A974BZ68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:kifbp.S
gene id: 8355:kifbp.S
uniprot id: A0A1L8FES6
uniprot id: A0A974HA84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KIF-binding protein family.
messages: cytoskeleton

8355:tlr22.S
gene id: 8355:tlr22.S
uniprot id: A0A8J0UX14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

8355:LOC121400801
gene id: 8355:LOC121400801
uniprot id: A0A8J1MG43
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:LOC495518
gene id: 8355:LOC495518
uniprot id: A0A974BS89
uniprot id: Q5U487
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

8355:myo16.L
gene id: 8355:myo16.L
uniprot id: A0A8J1M9F0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8355:LOC108719599
gene id: 8355:LOC108719599
uniprot id: A0A8J1MT11
uniprot id: A0A8J1MT81
uniprot id: A0A8J1MU37
uniprot id: A0A8J1MUE7
uniprot id: A0A8J1MVB3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:naa35.S
gene id: 8355:naa35.S
uniprot id: A0A1L8HP96
uniprot id: A0A974DTN7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAK10 family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
messages: Cytoplasm

8355:gabrr3.L
gene id: 8355:gabrr3.L
uniprot id: A0A1L8HCT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8355:dcn.L
gene id: 8355:dcn.L
uniprot id: A0A974DBK1
uniprot id: Q66J59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.
messages: May affect the rate of fibrils formation.
messages: extracellular matrix

8355:adtrp.S
gene id: 8355:adtrp.S
uniprot id: A0A8J1L3X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

8355:LOC108708435
gene id: 8355:LOC108708435
uniprot id: A0A1L8HH36
uniprot id: A0A974DQX4
names: Subcellular Location Annotation
messages: Membrane

8355:gpr4.L
gene id: 8355:gpr4.L
uniprot id: A0A8J0TIX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108695407
gene id: 8355:LOC108695407
uniprot id: A0A1L8FTL6
uniprot id: A0A974CKH9
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

8355:zbtb33.S
gene id: 8355:zbtb33.S
uniprot id: Q8UVQ4
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Expressed maternally and throughout development. Expressed in the animal hemisphere of eggs and cleavage stage embryos. Expressed in the ectodermal region of blastula and gastrula stage embryos and in the anterior and dorsal regions of neurula stage embryos. Expressed in the brain, ear, eye, branchial arches and spinal cord of tailbud stage embryos.
messages: Nucleus
messages: Self associates. Interacts with tcf7l1-A, leading to repression of tcf7l1-A target genes. Interacts with ctnnd1, and this interaction may inhibit DNA-binding. Interacts with ncor1.
messages: Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. May recruit the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. Contributes to the repression of target genes of the Wnt signaling pathway and to the methylation-dependent repression of zygotic transcription prior to the mid-blastula transition (MBT). Also required for gastrulation movements.

8355:LOC108708274
gene id: 8355:LOC108708274
uniprot id: A0A8J1M8U4
uniprot id: A0A8J1M8U5
uniprot id: A0A8J1M8U9
uniprot id: A0A8J1M8V0
uniprot id: A0A8J1M8V5
uniprot id: A0A8J1M8V6
uniprot id: A0A8J1M8W2
uniprot id: A0A8J1M8W3
uniprot id: A0A8J1M8W7
uniprot id: A0A8J1M8W8
uniprot id: A0A8J1M8Z5
uniprot id: A0A8J1M901
uniprot id: A0A8J1M908
uniprot id: A0A8J1M914
uniprot id: A0A8J1M921
uniprot id: A0A8J1M9U5
uniprot id: A0A8J1M9V0
uniprot id: A0A8J1M9V6
uniprot id: A0A8J1M9W8
uniprot id: A0A8J1MAM8
uniprot id: A0A8J1MAN4
uniprot id: A0A8J1MAN9
uniprot id: A0A8J1MAP4
uniprot id: A0A8J1MAQ0
names: Subcellular Location Annotation
messages: cytoskeleton

8355:crygdl.24.L
gene id: 8355:crygdl.24.L
uniprot id: A0A1L8HX01
uniprot id: A0A974I4B2
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:aplnr.L
gene id: 8355:aplnr.L
uniprot id: A0A974E122
uniprot id: P79960
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in all blood vessels including the posterior cardinal vein, intersomitic veins and the vitelline vein network. At the gastrula stage, exclusively expressed in the mesodermal layer and at the neurula stage in the lateral plate mesoderm. Larval expression is observed in the endothelium of the primary blood vessels and the forming heart.
messages: Expression starts in the late blastula (stage 8), increases during gastrulation and remains constant between neurula and larva stages.
messages: Membrane
messages: Receptor for apelin receptor early endogenous ligand (apela) and apelin (apln) hormones coupled to G proteins that inhibit adenylate cyclase activity (PubMed:17412318, PubMed:16750822, PubMed:16876154). Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively (By similarity). Promotes angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). May promote sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity). Required for cardiovascular development, particularly for intersomitic vein angiogenesis by acting as a receptor for apln hormone (PubMed:17412318, PubMed:16750822, PubMed:16876154). Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility, and heart failure (By similarity). Acts upstream of the i/o type of G-alpha proteins in the differentiation of endothelium, erythroid cells, myeloid cells and cardiomyocytes (PubMed:16876154).

8355:trarg1.L
gene id: 8355:trarg1.L
uniprot id: A0A1L8HD21
uniprot id: A0A974DMB9
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8355:rrm2b.S
gene id: 8355:rrm2b.S
uniprot id: A0A974CSW1
uniprot id: Q8AVY2
names: Cofactor
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.

8355:jak2.S
gene id: 8355:jak2.S
uniprot id: A0A8J1M2Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
messages: Endomembrane system
messages: Nucleus

8355:mak16.L
gene id: 8355:mak16.L
uniprot id: Q66L33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAK16 family.
messages: nucleolus

8355:atp6ap1.1.S
gene id: 8355:atp6ap1.1.S
uniprot id: Q5XH19
names: Similarity
messages: Belongs to the vacuolar ATPase subunit S1 family.

8355:LOC121403129
gene id: 8355:LOC121403129
uniprot id: A0A8J1MY80
uniprot id: A0A8J1MYG7
names: Similarity
messages: Belongs to the TAFA family.

8355:atp4b.L
gene id: 8355:atp4b.L
uniprot id: Q66KW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

8355:LOC108712232
gene id: 8355:LOC108712232
uniprot id: A0A8J0UTG2
uniprot id: A0A8J1KIU4
uniprot id: A0A8J1KIW2
uniprot id: A0A8J1KIW7
uniprot id: A0A8J1KIW8
names: Subcellular Location Annotation
messages: ruffle membrane

8355:pelp1.L
gene id: 8355:pelp1.L
uniprot id: A0A8J0URX3
uniprot id: Q58HI1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RIX1/PELP1 family.
messages: Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Regulates oocyte maturation. Enhances androgen receptor (AR)-mediated transcription in a SRC-dependent manner.
messages: Component of some MLL1/MLL complex (By similarity). Forms a signaling complex with SRC and estrogen receptors.
messages: Cytoplasm
messages: Expressed in oocyte.
messages: Nucleus
messages: The Glu-rich region mediates histones interaction.
messages: The Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are required for the association with nuclear receptor ESR1.

8355:gab3.L
gene id: 8355:gab3.L
uniprot id: A0A1L8F7C5
uniprot id: A0A8J0TK35
uniprot id: A0A974C7T9
names: Similarity
messages: Belongs to the GAB family.

8355:aqp2.L
gene id: 8355:aqp2.L
uniprot id: A0A1L8HIL4
uniprot id: A0A974HZ69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

8355:elovl2.L
gene id: 8355:elovl2.L
uniprot id: A0A974CNE5
uniprot id: Q68EU2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL2 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

8355:tuba1b.L
gene id: 8355:tuba1b.L
uniprot id: A0A1L8HHQ5
uniprot id: A0A974DQP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

8355:snrnp200.S
gene id: 8355:snrnp200.S
uniprot id: A0A1L8GS40
uniprot id: A0A974HQJ1
names: Similarity
messages: Belongs to the helicase family. SKI2 subfamily.

8355:mc4r.L
gene id: 8355:mc4r.L
uniprot id: A0A1L8FXM8
uniprot id: A0A974CNI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

8355:LOC108711086
gene id: 8355:LOC108711086
uniprot id: A0A1L8GYH2
uniprot id: A0A8J0UIH0
uniprot id: A0A8J0UPP8
uniprot id: A0A974DE55
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

8355:qrfpr.L
gene id: 8355:qrfpr.L
uniprot id: A0A1L8HV38
uniprot id: A0A974DY48
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:ccnt2.L
gene id: 8355:ccnt2.L
uniprot id: A0A1L8EVJ2
uniprot id: A0A8J0TUN1
uniprot id: A0A8J0TVT8
uniprot id: A0A974BYK5
names: Similarity
messages: Belongs to the cyclin family.

8355:csgalnact1.L
gene id: 8355:csgalnact1.L
uniprot id: A0A1L8HW87
uniprot id: A0A974E024
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

8355:LOC108708431
gene id: 8355:LOC108708431
uniprot id: A0A1L8HGW9
uniprot id: A0A8J1M9M9
uniprot id: A0A974HZ80
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:dlx4.S
gene id: 8355:dlx4.S
uniprot id: A0A1L8EL12
uniprot id: A0A974BSX2
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108700099
gene id: 8355:LOC108700099
uniprot id: A0A8J0TPH9
uniprot id: A0A8J1LPR7
uniprot id: A0A8J1LQX5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

8355:LOC108702158
gene id: 8355:LOC108702158
uniprot id: A0A1L8ENI4
uniprot id: A0A8J1LX85
uniprot id: A0A8J1LZ36
uniprot id: A0A974H0Z8
names: Subcellular Location Annotation
messages: Cytoplasm

8355:odf3.L
gene id: 8355:odf3.L
uniprot id: Q8AVY1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: 'Shippo' is a Japanese word for tail.
messages: Belongs to the CIMAP family.
messages: Cytoplasm
messages: Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. May help to maintain the passive elastic structures and elastic recoil of the sperm tail.
messages: flagellum

8355:prdm1.L
gene id: 8355:prdm1.L
uniprot id: A0A1L8G929
uniprot id: A0A974HJG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

8355:kbtbd8.S
gene id: 8355:kbtbd8.S
uniprot id: A0A1L8GI05
uniprot id: A0A8J0V459
uniprot id: A0A8J0V7I5
uniprot id: A0A974D0Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KBTBD8 family.
messages: Golgi apparatus
messages: spindle

8355:kcnt1.L
gene id: 8355:kcnt1.L
uniprot id: A0A8J1LFD8
uniprot id: A0A8J1LFE2
uniprot id: A0A8J1LFF6
uniprot id: A0A8J1LFG2
uniprot id: A0A8J1LFU5
uniprot id: A0A8J1LGU9
uniprot id: A0A8J1LHW4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:tgfbr1.S
gene id: 8355:tgfbr1.S
uniprot id: Q91595
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

8355:LOC121401495
gene id: 8355:LOC121401495
uniprot id: A0A8J1MLD2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:mogs.L
gene id: 8355:mogs.L
uniprot id: B1WBB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
messages: Endoplasmic reticulum membrane

8355:LOC121399337
gene id: 8355:LOC121399337
uniprot id: A0A8J1M3S8
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

8355:LOC108705457
gene id: 8355:LOC108705457
uniprot id: A0A8J1LTU2
uniprot id: A0A8J1LUF9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8355:LOC108710457
gene id: 8355:LOC108710457
uniprot id: A0A8J0UN42
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC733328
gene id: 8355:LOC733328
uniprot id: A0A1L8HN28
uniprot id: A0A8J0U7X1
uniprot id: A0A8J0U8V3
uniprot id: A0A8J1M277
uniprot id: A0A974I0P2
names: Similarity
messages: Belongs to the ARTD/PARP family.

8355:cyld.L
gene id: 8355:cyld.L
uniprot id: A0A1L8GKP3
uniprot id: A0A974D4U6
names: Subcellular Location Annotation
messages: centrosome
messages: perinuclear region

8355:LOC108716692
gene id: 8355:LOC108716692
uniprot id: A0A1L8G7V6
uniprot id: A0A974CWA0
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108698762
gene id: 8355:LOC108698762
uniprot id: A0A1L8F9V0
uniprot id: A0A974H8I9
names: Similarity
messages: Belongs to the GTP cyclohydrolase I family.

8355:LOC108716119
gene id: 8355:LOC108716119
uniprot id: A0A8J1KMX5
uniprot id: A0A8J1KMX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

8355:hhipl1.L
gene id: 8355:hhipl1.L
uniprot id: A0A8J0TXT9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108702276
gene id: 8355:LOC108702276
uniprot id: A0A8J1M0B4
uniprot id: A0A8J1M0B9
uniprot id: A0A8J1M0E0
uniprot id: A0A8J1M0G9
uniprot id: A0A8J1M0H3
uniprot id: A0A8J1M1J2
uniprot id: A0A8J1M2C7
uniprot id: A0A8J1M2D2
names: Similarity
messages: Belongs to the DIP2 family.

8355:LOC108708382
gene id: 8355:LOC108708382
uniprot id: A0A1L8HGQ4
uniprot id: A0A974DQD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

8355:adh1b.L
gene id: 8355:adh1b.L
uniprot id: A0A1L8HVB5
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

8355:LOC108702062
gene id: 8355:LOC108702062
uniprot id: A0A8J0TPR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuropeptide B/W family.
messages: Secreted

8355:LOC108709689
gene id: 8355:LOC108709689
uniprot id: A0A8J0UJQ0
uniprot id: A0A8J1MGB3
names: Similarity
messages: Belongs to the SH3RF family.

8355:pgm1.L
gene id: 8355:pgm1.L
uniprot id: A0A8J0USN8
uniprot id: Q7ZYA3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

8355:hlf.L
gene id: 8355:hlf.L
uniprot id: A0A1L8ETR1
uniprot id: A0A8J0TL01
uniprot id: A0A974H374
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

8355:gem.S
gene id: 8355:gem.S
uniprot id: A0A1L8FTH2
uniprot id: A0A974CLN2
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

8355:XB22063241.L
gene id: 8355:XB22063241.L
uniprot id: A0A1L8F8M0
uniprot id: A0A974H7L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPACA4/bouncer family.
messages: Cell membrane
messages: Membrane

8355:LOC121396201
gene id: 8355:LOC121396201
uniprot id: A0A8J1LCW2
names: Caution
names: Similarity
messages: Belongs to the DMBT1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:sbds.L
gene id: 8355:sbds.L
uniprot id: A0A1L8HG71
uniprot id: A0A974DNR2
names: Function
names: Similarity
messages: Belongs to the SDO1/SBDS family.
messages: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.

8355:cyrib.L
gene id: 8355:cyrib.L
uniprot id: A0A8J0VMK1
uniprot id: A0A974CPE0
uniprot id: Q8AVE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYRI family.
messages: Membrane

8355:enpep.S
gene id: 8355:enpep.S
uniprot id: A0A1L8HLZ8
uniprot id: A0A974DTD5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

8355:hdac6.L
gene id: 8355:hdac6.L
uniprot id: Q7ZYF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Cytoplasm

8355:atg9a.S
gene id: 8355:atg9a.S
uniprot id: A0A8J0TSW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

8355:LOC108705018
gene id: 8355:LOC108705018
uniprot id: A0A8J1MDM0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108704415
gene id: 8355:LOC108704415
uniprot id: A0A8J1KKH6
uniprot id: A0A8J1KNK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Mitochondrion inner membrane

8355:LOC108718085
gene id: 8355:LOC108718085
uniprot id: A0A8J0VD24
uniprot id: A0A8J1KWX3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

8355:shcbp1.L
gene id: 8355:shcbp1.L
uniprot id: A0A8J0UZC7
uniprot id: Q640F2
names: Function
names: Subcellular Location Annotation
messages: May play a role in signaling pathways governing cellular proliferation.
messages: Midbody
messages: spindle

8355:LOC108703726
gene id: 8355:LOC108703726
uniprot id: A0A8J0U3R0
uniprot id: A0A8J1M2J0
uniprot id: A0A8J1M2L0
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC121394441
gene id: 8355:LOC121394441
uniprot id: A0A8J1KVJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:kcnn2.S
gene id: 8355:kcnn2.S
uniprot id: A0A8J0UAI7
uniprot id: A0A8J1M3U9
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108709869
gene id: 8355:LOC108709869
uniprot id: A0A1L8HA21
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108702739
gene id: 8355:LOC108702739
uniprot id: A0A8J1LWX5
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:ap1s3.S
gene id: 8355:ap1s3.S
uniprot id: Q3KQD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

8355:LOC108705682
gene id: 8355:LOC108705682
uniprot id: A0A8J1L6W3
names: Similarity
messages: Belongs to the Speedy/Ringo family.

8355:rab27b.S
gene id: 8355:rab27b.S
uniprot id: Q6INW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

8355:casp10.L
gene id: 8355:casp10.L
uniprot id: A0A974H3Q4
uniprot id: Q6PAD9
names: Similarity
messages: Belongs to the peptidase C14A family.

8355:aldh7a1.L
gene id: 8355:aldh7a1.L
uniprot id: Q66J16
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.

8355:LOC108697170
gene id: 8355:LOC108697170
uniprot id: A0A8J0TE08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:col4a2.L
gene id: 8355:col4a2.L
uniprot id: A0A1L8HH05
uniprot id: A0A974DRF3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

8355:itga1.S
gene id: 8355:itga1.S
uniprot id: A0A1L8HRP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

8355:LOC108716988
gene id: 8355:LOC108716988
uniprot id: A0A1L8GAD9
uniprot id: A0A8J1KPJ3
uniprot id: A0A974HJU4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8355:slc13a2.S
gene id: 8355:slc13a2.S
uniprot id: A1L2L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

8355:clca4.1.L
gene id: 8355:clca4.1.L
uniprot id: F7IYU6
names: Similarity
messages: Belongs to the CLCR family.

8355:kcnj3.L
gene id: 8355:kcnj3.L
uniprot id: A0A1L8EVZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

8355:ep300.S
gene id: 8355:ep300.S
uniprot id: A0A1L8GGS2
uniprot id: A0A1L8GGW2
uniprot id: A0A8J0V3B0
uniprot id: A0A8J0V6R4
uniprot id: A0A8J0V6R9
uniprot id: A0A8J0V825
uniprot id: A0A8J0VC59
uniprot id: A0A974D202
uniprot id: A0A974D2K8
names: Subcellular Location Annotation
messages: Cytoplasm

8355:gpr87.L
gene id: 8355:gpr87.L
uniprot id: A0A1L8GAE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108697179
gene id: 8355:LOC108697179
uniprot id: A0A8J1LDU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

8355:spcs1.L
gene id: 8355:spcs1.L
uniprot id: A0A8J0QFB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:slc26a1.L
gene id: 8355:slc26a1.L
uniprot id: A0A974DY41
uniprot id: Q6XQ07
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sodium-independent sulfate anion transporter. Can transport other anions including bicarbonate, thiosulfate and oxalate.

8355:steap4.2.S
gene id: 8355:steap4.2.S
uniprot id: A0A1L8FQW2
uniprot id: A0A8J1L1H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

8355:crygdl.10.S
gene id: 8355:crygdl.10.S
uniprot id: A0A1L8HNP8
uniprot id: A0A974I1A2
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:mgrn1.S
gene id: 8355:mgrn1.S
uniprot id: A0A8J0TW99
uniprot id: Q6P7J2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin ligase.

8355:kifc3.L
gene id: 8355:kifc3.L
uniprot id: A0A1L8GLK9
uniprot id: A0A8J1MXK9
uniprot id: A0A8J1MYX1
uniprot id: A0A974HP50
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8355:prim1.S
gene id: 8355:prim1.S
uniprot id: A0A8J1MB50
uniprot id: A0A974HWK0
uniprot id: Q800A4
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

8355:LOC108700578
gene id: 8355:LOC108700578
uniprot id: A0A8J1LNX0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:pou2f1.L
gene id: 8355:pou2f1.L
uniprot id: A0A1L8HC31
uniprot id: A0A8J0U548
uniprot id: A0A8J0UC19
uniprot id: A0A8J0UDC1
uniprot id: A0A8J1M7R1
uniprot id: A0A974DL21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus

8355:LOC108709982
gene id: 8355:LOC108709982
uniprot id: A0A1L8HAS5
uniprot id: A0A974HWY7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

8355:foxe3.S
gene id: 8355:foxe3.S
uniprot id: A0A1L8GFU2
uniprot id: A0A974D1S0
names: Subcellular Location Annotation
messages: Nucleus

8355:ddb2.L
gene id: 8355:ddb2.L
uniprot id: A0A1L8GIW4
uniprot id: A0A974D3U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Nucleus

8355:atp6v1al.L
gene id: 8355:atp6v1al.L
uniprot id: A0A974CAT2
uniprot id: Q7ZY12
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

8355:atp6ap1.2.S
gene id: 8355:atp6ap1.2.S
uniprot id: A0A8J0TNA4
uniprot id: Q9PU12
names: Similarity
messages: Belongs to the vacuolar ATPase subunit S1 family.

8355:erbb4.L
gene id: 8355:erbb4.L
uniprot id: A0A8J1LQX7
uniprot id: Q153D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

8355:LOC108695882
gene id: 8355:LOC108695882
uniprot id: A0A8J0T913
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108710346
gene id: 8355:LOC108710346
uniprot id: A0A1L8H2A7
uniprot id: A0A974HU14
names: Subcellular Location Annotation
messages: Membrane

8355:iah1.L
gene id: 8355:iah1.L
uniprot id: A0A1L8GBZ9
uniprot id: A0A974CYP0
names: Function
names: Similarity
messages: Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.
messages: Probable lipase.

8355:timm13.S
gene id: 8355:timm13.S
uniprot id: Q8AVK1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer; composed of 3 copies of TIMM8 (TIMM8A or TIMM8B) and 3 copies of TIMM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIMM22 (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of some proteins while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins (By similarity).
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of timm13-B from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

8355:atp11b.L
gene id: 8355:atp11b.L
uniprot id: A0A1L8GAF9
uniprot id: A0A8J0VC84
uniprot id: A0A8J1KPJ7
uniprot id: A0A8J1KPK3
uniprot id: A0A8J1KPL0
uniprot id: A0A8J1KSP9
uniprot id: A0A974CVM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

8355:sidt1.L
gene id: 8355:sidt1.L
uniprot id: A0A8J1M7P8
uniprot id: A0A8J1M8I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SID1 family.
messages: Membrane

8355:mcoln3.S
gene id: 8355:mcoln3.S
uniprot id: A0A1L8GLL6
uniprot id: A0A8J1MV35
uniprot id: A0A8J1MW20
uniprot id: Q6GPE7
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

8355:brox.S
gene id: 8355:brox.S
uniprot id: A0A1L8G180
uniprot id: A0A974HGW0
names: Similarity
messages: Belongs to the BROX family.

8355:p4hb.L
gene id: 8355:p4hb.L
uniprot id: A0A8J0TSV1
uniprot id: A0A974BXX6
uniprot id: Q6DD55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

8355:LOC108699172
gene id: 8355:LOC108699172
uniprot id: A0A8J0TJ75
uniprot id: A0A8J1LHZ6
uniprot id: A0A8J1LI26
uniprot id: A0A8J1LIN0
uniprot id: A0A8J1LJC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

8355:med15.L
gene id: 8355:med15.L
uniprot id: A0A1L8I0E1
uniprot id: A0A8J0TR04
uniprot id: A0A8J0TZL0
uniprot id: A0A974I576
uniprot id: Q6NS15
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 15 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation (By similarity). Positively regulates the Nodal signaling pathway.
messages: Component of the Mediator complex.
messages: Component of the Mediator complex. Interacts with srebf1 and srebf2 (By similarity). Interacts with smad2, smad3 and smad4.
messages: Cytoplasm
messages: Expressed maternally and throughout embryogenesis.
messages: Nucleus

8355:nes.L
gene id: 8355:nes.L
uniprot id: A0A1L8FCC8
uniprot id: A0A974H9F3
names: Similarity
messages: Belongs to the intermediate filament family.

8355:cuta.L
gene id: 8355:cuta.L
uniprot id: A0A8J1LEN7
uniprot id: Q66KY3
names: Similarity
names: Subunit
messages: Belongs to the CutA family.
messages: Homotrimer.

8355:nhp2.S
gene id: 8355:nhp2.S
uniprot id: A0A1L8GUY5
uniprot id: A0A974DB40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

8355:efnb2.S
gene id: 8355:efnb2.S
uniprot id: B0FLR3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:LOC121401296
gene id: 8355:LOC121401296
uniprot id: A0A8J1MIN8
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108702682
gene id: 8355:LOC108702682
uniprot id: A0A1L8ELX0
uniprot id: A0A974BT76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:usp22.L
gene id: 8355:usp22.L
uniprot id: A0A1L8EXA2
uniprot id: A0A8J1LS47
uniprot id: Q6GNI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family.
messages: Belongs to the peptidase C19 family. UBP8 subfamily.
messages: Component of some SAGA transcription coactivator-HAT complexes.
messages: Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators, where it is required for transcription (By similarity).
messages: Nucleus

8355:sctr.L
gene id: 8355:sctr.L
uniprot id: A0A8J1LPB7
uniprot id: A0A974H348
uniprot id: F8RUA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

8355:xrn1.S
gene id: 8355:xrn1.S
uniprot id: A0A8J0VD94
uniprot id: A0A8J1KVU9
uniprot id: A0A8J1KXA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-3' exonuclease family.
messages: Cytoplasm

8355:LOC121401684
gene id: 8355:LOC121401684
uniprot id: A0A8J1MNJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8355:trappc1.S
gene id: 8355:trappc1.S
uniprot id: Q5I049
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

8355:LOC121400765
gene id: 8355:LOC121400765
uniprot id: A0A1L8H6C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:tmprss2.3.L
gene id: 8355:tmprss2.3.L
uniprot id: A0A8J1M573
uniprot id: A0A8J1M712
uniprot id: Q6NUF5
uniprot id: Q9DGR2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:pard6b.S
gene id: 8355:pard6b.S
uniprot id: A0A1L8ELH2
uniprot id: A0A974BSV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

8355:dipk1a.S
gene id: 8355:dipk1a.S
uniprot id: A0A1L8GG90
uniprot id: A0A974CZE1
names: Similarity
messages: Belongs to the DIPK family.

8355:ap3d1.L
gene id: 8355:ap3d1.L
uniprot id: A0A1L8HWU3
uniprot id: A0A974I448
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

8355:LOC108702184
gene id: 8355:LOC108702184
uniprot id: A0A8J1M1X6
names: Subcellular Location Annotation
messages: Secreted

8355:slc23a1.L
gene id: 8355:slc23a1.L
uniprot id: A0A8J1MJR3
uniprot id: A0A8J1MLT6
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108698377
gene id: 8355:LOC108698377
uniprot id: A0A8J0TGP9
uniprot id: A0A8J0TK24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

8355:LOC108711262
gene id: 8355:LOC108711262
uniprot id: A0A8J1MM76
uniprot id: A0A8J1MND7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Postsynaptic density

8355:LOC108697026
gene id: 8355:LOC108697026
uniprot id: A0A1L8FMW1
uniprot id: A0A974HCI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

8355:slc7a13.S
gene id: 8355:slc7a13.S
uniprot id: Q6PAW4
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108715533
gene id: 8355:LOC108715533
uniprot id: A0A1L8GFH5
uniprot id: A0A8J0V2D6
uniprot id: A0A8J0V2E1
uniprot id: A0A8J0V7A7
uniprot id: A0A8J0VBC0
uniprot id: A0A8J1KJ04
uniprot id: A0A8J1KJ10
uniprot id: A0A8J1KJ22
uniprot id: A0A8J1KJ31
uniprot id: A0A8J1KKR4
uniprot id: A0A8J1KKR9
uniprot id: A0A8J1KM72
uniprot id: A0A974CZC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

8355:plscr2.S
gene id: 8355:plscr2.S
uniprot id: A0A1L8G4F4
uniprot id: A0A8J1KRU5
uniprot id: A0JMY8
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

8355:chst8.S
gene id: 8355:chst8.S
uniprot id: A0A8J0U4L2
uniprot id: A0A8J0U6M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:lvrn.L
gene id: 8355:lvrn.L
uniprot id: A0A1L8I1H6
uniprot id: A0A974E3W1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

8355:wnt1.S
gene id: 8355:wnt1.S
uniprot id: A0A1L8H9S8
uniprot id: A0A974HWR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8355:LOC108718198
gene id: 8355:LOC108718198
uniprot id: A0A1L8G586
uniprot id: A0A974HIK2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: dendrite

8355:cryba4.S
gene id: 8355:cryba4.S
uniprot id: A0A974HV66
uniprot id: Q7SZ91
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:pygl.L
gene id: 8355:pygl.L
uniprot id: A0A1L8F9Y5
uniprot id: A0A974C865
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

8355:slc22a2.L
gene id: 8355:slc22a2.L
uniprot id: A0A8J1KN70
uniprot id: Q66J42
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

8355:LOC779056
gene id: 8355:LOC779056
uniprot id: A0A1L8H5Q6
uniprot id: A0A8J0UJJ6
uniprot id: A0A974DGT2
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

8355:LOC108714416
gene id: 8355:LOC108714416
uniprot id: A0A1L8GN11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:rab3b.L
gene id: 8355:rab3b.L
uniprot id: A0A974HP19
uniprot id: Q6GLK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

8355:LOC121398056
gene id: 8355:LOC121398056
uniprot id: A0A8J1LSM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8355:LOC108718636
gene id: 8355:LOC108718636
uniprot id: A0A8J1KYU8
names: Subcellular Location Annotation
messages: Membrane

8355:lmbr1l.S
gene id: 8355:lmbr1l.S
uniprot id: A0A1L8H9I8
uniprot id: A0A974DL95
names: Similarity
messages: Belongs to the LIMR family.

8355:fbn2.L
gene id: 8355:fbn2.L
uniprot id: A0A1L8I1D3
uniprot id: A0A974I5V3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8355:mgat5b.S
gene id: 8355:mgat5b.S
uniprot id: A0A1L8EN27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 18 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:dtx4.L
gene id: 8355:dtx4.L
uniprot id: A0A8J0SZV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

8355:en2.L
gene id: 8355:en2.L
uniprot id: A0A974CNH1
uniprot id: P52729
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Engrailed homeobox family.
messages: Belongs to the engrailed homeobox family.
messages: In addition to the main band of expression at the midbrain-hindbrain boundary, the protein is expressed in the mandibular arch, the optic tectum and the region of anterior pituitary.
messages: Nucleus

8355:psmd9.S
gene id: 8355:psmd9.S
uniprot id: A0A974I253
uniprot id: Q8AVD0
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

8355:slc44a2.S
gene id: 8355:slc44a2.S
uniprot id: A0A8J0U1U3
uniprot id: A0A8J0U268
uniprot id: A0A8J0U347
uniprot id: A0A8J0U527
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

8355:cd82.L
gene id: 8355:cd82.L
uniprot id: A0A974D3T6
uniprot id: Q6IP10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8355:atp13a2.L
gene id: 8355:atp13a2.L
uniprot id: A0A8J0T3U6
uniprot id: A0A8J0TA43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

8355:sla.L
gene id: 8355:sla.L
uniprot id: A0A1L8G010
uniprot id: A0A974CPE5
names: Subcellular Location Annotation
messages: Cytoplasm

8355:mcm4.L
gene id: 8355:mcm4.L
uniprot id: P30664
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the mcm2-7 complex (RLF-M) (PubMed:16369567, PubMed:8901561, PubMed:9851868). The complex forms a toroidal hexameric ring with the proposed subunit order mcm2-mcm6-mcm4-mcm7-mcm3-mcm5 (PubMed:16369567, PubMed:8901561, PubMed:9851868). The heterodimer of mmcm3/mcm5 interacts with mcm4, mmcm6, mcm7 and weakly with mcm2 (PubMed:16369567, PubMed:8901561, PubMed:9851868). Begins to associate with zmcm6 at the neurula stage (PubMed:9512418). Component of the CMG helicase complex, composed of the mcm2-7 complex, the GINS complex and cdc45 (PubMed:30842657).
messages: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.
messages: Expressed throughout development.
messages: Hyperphosphorylated during mitosis in a mechanism requiring cdc2-cyclin B and other kinases. Undergoes dephosphorylation after exiting mitosis, existing in a partially phosphorylated state in the cytosolic interphase mcm complex which associates with the pre-replication complexes (pre-Rcs). Complete dephosphorylation inactivates the mcm complex, preventing its binding to chromatin. Becomes actively phosphorylated during S phase once the mcm complex is assembled on the chromatin. This chromatin-associated phosphorylation occurs during the activation of the pre-Rcs and is independent of cdks. Phosphorylated by the cdc7-dbf4b complex.
messages: Nucleus

8355:XB5745823.L
gene id: 8355:XB5745823.L
uniprot id: A0A974C018
uniprot id: A2VDC3
names: Similarity
messages: Belongs to the globin family.

8355:LOC108699855
gene id: 8355:LOC108699855
uniprot id: A0A1L8F0T7
uniprot id: A0A8J0TFU6
uniprot id: A0A8J0TMA8
uniprot id: A0A8J0TPH2
uniprot id: A0A8J0TQI7
uniprot id: A0A8J1LMX7
uniprot id: A0A8J1LP97
uniprot id: A0A974C254
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8355:rexo4.S
gene id: 8355:rexo4.S
uniprot id: A0A1L8F115
uniprot id: A0A974C2D5
uniprot id: Q91560
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REXO4 family.
messages: Nucleus

8355:sox4.L
gene id: 8355:sox4.L
uniprot id: Q6PCK0
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC121395114
gene id: 8355:LOC121395114
uniprot id: A0A8J1L4X0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

8355:nt5e.S
gene id: 8355:nt5e.S
uniprot id: A0A974HHR1
uniprot id: Q4V809
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-nucleotidase family.
messages: Membrane

8355:stat2.S
gene id: 8355:stat2.S
uniprot id: A0A1L8H9P8
uniprot id: A0A8J1MF37
uniprot id: A0A8J1MF43
uniprot id: A0A8J1MFM0
uniprot id: A0A974DIV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

8355:atp8a1.S
gene id: 8355:atp8a1.S
uniprot id: A0A8J0U730
uniprot id: A0A8J1M0W9
uniprot id: A0A8J1M2X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

8355:tbx18.S
gene id: 8355:tbx18.S
uniprot id: A0A1L8G3B1
uniprot id: A0A974HHL4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8355:LOC108704782
gene id: 8355:LOC108704782
uniprot id: A0A8J0U888
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:ccn4.S
gene id: 8355:ccn4.S
uniprot id: A0A1L8FU26
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:kit.L
gene id: 8355:kit.L
uniprot id: A0A8J0UTF6
uniprot id: Q91909
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Autophosphorylated on tyrosine residues. Phosphorylated tyrosine residues are important for interaction with specific binding partners (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: During embryogenesis, maternal transcripts levels are very low through cleavage and blastula stages. Zygotic transcripts are first detected in the early gastrula at stage 10. Transcripts levels increase through tailbud and tadpole stages. At stages 31/32, expression is seen at the surface of the embryo in a line ventral to the posterior edge of the optic cup. At stages 33/34, two short lines of cells exist running ventrally from the anterior edge of the otic vesicle. At stages 35/36, expression is seen in cells near the cement gland and in a patch of cells located posterior to the gill arches, and just beneath or within the inner layer of the epidermis. At stages 37/38, expression forms a ribbon on either side of the embryo. At stages 40, a second line runs caudally along the flank of the embryo. By stage 42, extension occurs and a line is observed ventro-caudally around the anus.
messages: Expressed in a migratory stem cell population.
messages: Membrane
messages: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine kitlg/scf and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.
messages: Ubiquitinated. Rapidly ubiquitinated after autophosphorylation induced by kitlg/scf binding, leading to internalization and degradation.

8355:LOC108715724
gene id: 8355:LOC108715724
uniprot id: A0A1L8HZZ6
uniprot id: A0A8J0V830
uniprot id: A0A974E181
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

8355:scrn3.L
gene id: 8355:scrn3.L
uniprot id: A0A8J0TSA5
uniprot id: A0A8J1LTD0
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

8355:rnf138.S
gene id: 8355:rnf138.S
uniprot id: Q1L721
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Auto-ubiquitinated.
messages: Chromosome
messages: E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (By similarity). Together with nlk.2, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with ube2k. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285).
messages: Interacts with nlk.2 (via C-terminus) and ube2k.
messages: The zinc finger domains (C2H2-type and C2HC-type zinc fingers) bind DNA and mediate recruitment to double-strand break sites. They show strong preference for DNA with 5'- or 3'-single-stranded overhangs, while they do not bind blunt-ended double-stranded DNA or poly(ADP-ribose) (PAR) polymers.

8355:tll1.S
gene id: 8355:tll1.S
uniprot id: Q8JI28
names: Cofactor
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Expressed in the marginal zone of mid-gastrulae, and in ventral and lateral sectors. At neurula stages, strongly expressed around the blastopore and in the pharyngeal endoderm, and more weakly expressed throughout the ventral half of the embryo. Transcripts are detected in the nervous system, particularly the hindbrain and spinal cord, and tailbud of tailbud stage embryos, with weaker expression in the anterior nervous system, otic vesicle, heart, and pronephric duct. Transcription is increased by BMP4 and decreased by Noggin and tBR, indicating that it is regulated by BMP signaling.
messages: Protease which processes procollagen C-propeptides, such as chordin. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.
messages: Secreted

8355:LOC121393576
gene id: 8355:LOC121393576
uniprot id: A0A8J1KLX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8355:nek6.L
gene id: 8355:nek6.L
uniprot id: A0A974H7B6
uniprot id: A1L2I8
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:or51g2.L
gene id: 8355:or51g2.L
uniprot id: A0A8J0UBL9
names: Subcellular Location Annotation
messages: Membrane

8355:avd.2.L
gene id: 8355:avd.2.L
uniprot id: A0A1L8EUL7
uniprot id: A0A974BXV2
names: Similarity
messages: Belongs to the avidin/streptavidin family.

8355:popdc2.L
gene id: 8355:popdc2.L
uniprot id: A0A1L8HBV2
uniprot id: A0A8J0U505
uniprot id: A0A8J0UD84
uniprot id: A0A8J1M8G2
names: Similarity
messages: Belongs to the popeye family.

8355:khsrp.S
gene id: 8355:khsrp.S
uniprot id: A0A8J0U2Y3
uniprot id: Q8AX85
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108708421
gene id: 8355:LOC108708421
uniprot id: A0A8J0UEH7
names: Similarity
messages: Belongs to the AF4 family.

8355:trmt11.L
gene id: 8355:trmt11.L
uniprot id: Q6NS23
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.

8355:aspn.L
gene id: 8355:aspn.L
uniprot id: Q5XHD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: extracellular matrix

8355:ppp1r10.S
gene id: 8355:ppp1r10.S
uniprot id: A0A1L8F3R2
uniprot id: A0A974C3T7
uniprot id: Q6GLQ4
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Probable inhibitor of phosphatase activity.

8355:saal1.L
gene id: 8355:saal1.L
uniprot id: Q6DCP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAAL1 family.
messages: Nucleus
messages: Plays a role in promoting cell proliferation in response to pro-inflammatory stimuli.

8355:adam28.1.S
gene id: 8355:adam28.1.S
uniprot id: A0A8J0UP88
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:calhm2.L
gene id: 8355:calhm2.L
uniprot id: A0A1L8FJ92
uniprot id: A0A8J1L4X6
uniprot id: A0A974HBE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

8355:tet2.S
gene id: 8355:tet2.S
uniprot id: A0A1L8HM87
uniprot id: A0A8J0U8H1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Chromosome
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

8355:slc26a2.2.S
gene id: 8355:slc26a2.2.S
uniprot id: A0A1L8GV37
uniprot id: A0A974D9F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

8355:hibch.L
gene id: 8355:hibch.L
uniprot id: A2VDC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity).
messages: Mitochondrion

8355:slc26a2.S
gene id: 8355:slc26a2.S
uniprot id: A0A1L8GV50
uniprot id: A0A974D969
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions. The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange. Essential for chondrocyte proliferation, differentiation and cell size expansion.

8355:lif.L
gene id: 8355:lif.L
uniprot id: A0A1L8HZU9
uniprot id: A0A974I4Q6
names: Function
messages: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.

8355:XB5907626.S
gene id: 8355:XB5907626.S
uniprot id: A0A8J0U4K5
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

8355:LOC121400093
gene id: 8355:LOC121400093
uniprot id: A0A8J1MBS9
uniprot id: A0A8J1MCK1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:spcs2.L
gene id: 8355:spcs2.L
uniprot id: A0A8J0UCZ6
uniprot id: A0A8J0UFL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS2 family.
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:xrn2.S
gene id: 8355:xrn2.S
uniprot id: A0A8J1KR47
names: Function
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

8355:LOC108699505
gene id: 8355:LOC108699505
uniprot id: A0A8J0TLV6
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

8355:ndufb3.S
gene id: 8355:ndufb3.S
uniprot id: A0A1L8EPN2
uniprot id: A0A974BV33
uniprot id: Q6GQ45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB3 subunit family.
messages: Mitochondrion inner membrane

8355:ncln.L
gene id: 8355:ncln.L
uniprot id: A0A1L8HXX6
uniprot id: A0A974E072
uniprot id: Q6GQK1
names: Function
names: Similarity
messages: Belongs to the nicastrin family.
messages: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.

8355:tpp2.S
gene id: 8355:tpp2.S
uniprot id: A0A1L8H901
uniprot id: A0A8J0ULB1
uniprot id: A0A974DID0
names: Similarity
messages: Belongs to the peptidase S8 family.

8355:sult2b1.L
gene id: 8355:sult2b1.L
uniprot id: A0A8J1L3W8
uniprot id: A0A974CHS1
uniprot id: A1L2N2
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8355:LOC108700617
gene id: 8355:LOC108700617
uniprot id: A0A8J1LLV3
names: Similarity
messages: Belongs to the intermediate filament family.

8355:ace2.S
gene id: 8355:ace2.S
uniprot id: A0A8J0UHV7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Secreted
messages: cilium

8355:rhbdl2.S
gene id: 8355:rhbdl2.S
uniprot id: A0A8J1MFM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Membrane

8355:lhcgr-A
gene id: 8355:lhcgr-A
uniprot id: G9M6I1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

8355:xxylt1.S
gene id: 8355:xxylt1.S
uniprot id: A0A8J0PYJ7
uniprot id: Q6DFE5
names: Subcellular Location Annotation
messages: Membrane

8355:LOC121402277
gene id: 8355:LOC121402277
uniprot id: A0A8J1MTN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8355:stk38l.L
gene id: 8355:stk38l.L
uniprot id: A0A1L8GVZ3
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:ubald2.L
gene id: 8355:ubald2.L
uniprot id: A0A974BY66
uniprot id: Q6IP57
names: Similarity
messages: Belongs to the UBALD family.

8355:rcan1.L
gene id: 8355:rcan1.L
uniprot id: A0A1L8HCJ8
uniprot id: A0A8J1M517
uniprot id: A0A974DMC3
uniprot id: Q7T0U1
names: Similarity
messages: Belongs to the RCAN family.

8355:LOC108705973
gene id: 8355:LOC108705973
uniprot id: A0A8J0U6I7
names: Subcellular Location Annotation
messages: Membrane

8355:tspyl2.L
gene id: 8355:tspyl2.L
uniprot id: B1WBC5
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

8355:LOC108703449
gene id: 8355:LOC108703449
uniprot id: A0A8J0U241
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:cystm1.L
gene id: 8355:cystm1.L
uniprot id: A0A1L8GXA9
uniprot id: A0A974DBV4
names: Similarity
messages: Belongs to the CYSTM1 family.

8355:h2az2.S
gene id: 8355:h2az2.S
uniprot id: Q6GM74
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-5, Lys-8 and Lys-12 when associated with the 5'-end of active genes.
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AZ2 forms a heterodimer with H2B (By similarity).
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity).

8355:LOC108712370
gene id: 8355:LOC108712370
uniprot id: A0A8J1KJN9
uniprot id: A0A8J1KJQ0
uniprot id: A0A8J1KJR1
uniprot id: A0A8J1KJS8
uniprot id: A0A8J1KJT0
uniprot id: A0A8J1KJU0
uniprot id: A0A8J1KMT2
uniprot id: A0A8J1KMT7
uniprot id: A0A8J1KMU2
names: Subcellular Location Annotation
messages: Cytoplasm

8355:ndufa5.S
gene id: 8355:ndufa5.S
uniprot id: A0A1L8GU71
uniprot id: A0A974HRK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

8355:LOC108706449
gene id: 8355:LOC108706449
uniprot id: A0A1L8HRA4
uniprot id: A0A974DVJ5
names: Similarity
messages: Belongs to the avidin/streptavidin family.

8355:mospd1.L
gene id: 8355:mospd1.L
uniprot id: A0A8J1LFQ9
uniprot id: Q7SYQ6
names: Subcellular Location Annotation
messages: Membrane

8355:nudt12.S
gene id: 8355:nudt12.S
uniprot id: A0A1L8HR39
uniprot id: A0A974I1M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Cytoplasmic granule
messages: Peroxisome

8355:LOC108712508
gene id: 8355:LOC108712508
uniprot id: A0A1L8GQ56
uniprot id: A0A8J0UNE5
uniprot id: A0A8J0UU42
uniprot id: A0A974HPT0
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

8355:anapc10.S
gene id: 8355:anapc10.S
uniprot id: A0A974I0D8
uniprot id: Q5EAZ2
names: Function
names: Similarity
messages: Belongs to the APC10 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.

8355:ola1.S
gene id: 8355:ola1.S
uniprot id: A0A1L8EPB9
uniprot id: A0A8J0TT76
uniprot id: A0A974BUX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Cytoplasm
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
messages: Monomer.
messages: Nucleus
messages: nucleolus

8355:topaz1.L
gene id: 8355:topaz1.L
uniprot id: A0A1L8FWF9
uniprot id: A0A8J0VJ52
uniprot id: A0A8J1KXC6
uniprot id: A0A974CLZ4
names: Function
messages: Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.

8355:LOC108712987
gene id: 8355:LOC108712987
uniprot id: A0A1L8GTB1
uniprot id: A0A974HQS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

8355:fancm.L
gene id: 8355:fancm.L
uniprot id: A0A8J1LE47
uniprot id: D5MDW0
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.

8355:LOC108701862
gene id: 8355:LOC108701862
uniprot id: A0A1L8EWY0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
messages: Homodimer; disulfide-linked.
messages: Membrane

8355:slc19a3.2.L
gene id: 8355:slc19a3.2.L
uniprot id: A0A1L8GAZ4
uniprot id: A0A974CWB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Membrane

8355:clip3.S
gene id: 8355:clip3.S
uniprot id: Q5U243
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics (By similarity).
messages: Golgi stack
messages: Homodimer.
messages: Microtubule association is inhibited by the ANK repeats and the Golgi localization region (GoLD).
messages: The N-terminal half is dispensable for proper Golgi targeting, whereas the GoLD region is required.

8355:f13b.L
gene id: 8355:f13b.L
uniprot id: A0A1L8GN92
uniprot id: A0A8J0V2S5
uniprot id: A0A8J1MXP5
uniprot id: A0A8J1MZ57
uniprot id: A0A974D497
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC121399775
gene id: 8355:LOC121399775
uniprot id: A0A8J1M7I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:sorl1.L
gene id: 8355:sorl1.L
uniprot id: A0A1L8FLB9
uniprot id: A0A8J1L963
uniprot id: A0A974CHT0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS10-related sortilin family. SORL1 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Recycling endosome membrane
messages: Secreted
messages: multivesicular body membrane
messages: secretory vesicle membrane
messages: trans-Golgi network membrane

8355:gpc5.S
gene id: 8355:gpc5.S
uniprot id: A0A1L8G4P3
uniprot id: A0A8J0VLS4
uniprot id: A0A974HI92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

8355:wnk1.S
gene id: 8355:wnk1.S
uniprot id: A0A8J1MPZ6
uniprot id: A0A8J1MQ01
uniprot id: A0A8J1MQ08
uniprot id: A0A8J1MQ49
uniprot id: A0A8J1MQ54
uniprot id: A0A8J1MQ61
uniprot id: A0A8J1MR01
uniprot id: A0A8J1MR06
uniprot id: A0A8J1MR64
uniprot id: A0A8J1MR70
uniprot id: A0A8J1MR75
uniprot id: A0A8J1MS77
uniprot id: A0A8J1MS83
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

8355:papss2.S
gene id: 8355:papss2.S
uniprot id: A0A1L8FE41
uniprot id: A0A974HA07
uniprot id: Q6PA85
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

8355:LOC108703518
gene id: 8355:LOC108703518
uniprot id: A0A8J0TUR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

8355:LOC121399801
gene id: 8355:LOC121399801
uniprot id: A0A8J1M7T4
uniprot id: A0A8J1M8L7
names: Subcellular Location Annotation
messages: Secreted

8355:gpr155.L
gene id: 8355:gpr155.L
uniprot id: A0A1L8EWG6
uniprot id: A0A8J0TUN9
uniprot id: A0A8J0TV57
uniprot id: A0A974H3I8
names: Subcellular Location Annotation
messages: Membrane

8355:dock9.L
gene id: 8355:dock9.L
uniprot id: A0A8J0Q9J6
uniprot id: A0A8J0UA52
uniprot id: A0A8J1M4S2
uniprot id: A0A8J1M4S3
uniprot id: A0A8J1M4S5
uniprot id: A0A8J1M4S8
uniprot id: A0A8J1M4S9
uniprot id: A0A8J1M4T0
uniprot id: A0A8J1M4T2
uniprot id: A0A8J1M4T3
uniprot id: A0A8J1M4T4
uniprot id: A0A8J1M4T7
uniprot id: A0A8J1M4T8
uniprot id: A0A8J1M4T9
uniprot id: A0A8J1M5V0
uniprot id: A0A8J1M5V5
uniprot id: A0A8J1M5W1
uniprot id: A0A8J1M5W6
uniprot id: A0A8J1M6K5
uniprot id: A0A8J1M6L3
uniprot id: A0A8J1M6L9
uniprot id: A0A8J1M6M4
names: Similarity
messages: Belongs to the DOCK family.

8355:cftr.L
gene id: 8355:cftr.L
uniprot id: A0A1L8GYY2
uniprot id: A0A8J0UR68
uniprot id: A0A974HSU1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Recycling endosome membrane

8355:sdr42e1.L
gene id: 8355:sdr42e1.L
uniprot id: Q0IH73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-beta-HSD family.
messages: Membrane

8355:dnah7.L
gene id: 8355:dnah7.L
uniprot id: A0A8J1LUB2
uniprot id: A0A8J1LUB6
names: Similarity
messages: Belongs to the dynein heavy chain family.

8355:nipsnap3a.S
gene id: 8355:nipsnap3a.S
uniprot id: Q6PA66
names: Similarity
messages: Belongs to the NipSnap family.

8355:sugt1.L
gene id: 8355:sugt1.L
uniprot id: A0A1L8HHK1
uniprot id: A0A974DQ77
uniprot id: Q6IP01
names: Similarity
messages: Belongs to the SGT1 family.

8355:pgls.S
gene id: 8355:pgls.S
uniprot id: A0A8J0QGJ1
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

8355:mrpl46.L
gene id: 8355:mrpl46.L
uniprot id: A0A1L8H0Y3
uniprot id: A0A974HTK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Mitochondrion

8355:tac1.S
gene id: 8355:tac1.S
uniprot id: A0A1L8FR38
uniprot id: A0A8J1L0Y2
uniprot id: A0A974HDJ6
uniprot id: Q58E04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted
messages: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

8355:mief1.L
gene id: 8355:mief1.L
uniprot id: A0A8J1MXQ5
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

8355:ocm4.1.L
gene id: 8355:ocm4.1.L
uniprot id: A0A974C074
uniprot id: Q8AVD4
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

8355:rnf4.S
gene id: 8355:rnf4.S
uniprot id: A0A974DSH8
uniprot id: Q5PQ91
names: Subcellular Location Annotation
messages: Nucleus

8355:cdk5rap3.S
gene id: 8355:cdk5rap3.S
uniprot id: A0A1L8EKU3
uniprot id: A0A8J1LZ27
names: Similarity
messages: Belongs to the CDK5RAP3 family.

8355:LOC121398358
gene id: 8355:LOC121398358
uniprot id: A0A8J1LVT9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Nematocyst
messages: Target cell membrane

8355:LOC108717501
gene id: 8355:LOC108717501
uniprot id: A0A8J1KUN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

8355:otop2.L
gene id: 8355:otop2.L
uniprot id: A0A8J1LT12
uniprot id: A0A8J1LT17
uniprot id: A0A8J1LTQ3
uniprot id: A0A8J1LUI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

8355:lars1.L
gene id: 8355:lars1.L
uniprot id: A0A974DB72
uniprot id: Q6AX83
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

8355:gna13.S
gene id: 8355:gna13.S
uniprot id: A0A974H108
uniprot id: Q5HZN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

8355:ptpn4.L
gene id: 8355:ptpn4.L
uniprot id: A0A1L8EVC9
uniprot id: A0A8J0TUJ8
uniprot id: A0A8J0TVQ8
uniprot id: A0A8J1LSY7
uniprot id: A0A8J1LUD8
uniprot id: A0A974BYR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

8355:slc26a9.L
gene id: 8355:slc26a9.L
uniprot id: A0A1L8HET5
uniprot id: A0A8J1M876
uniprot id: A0A974DP47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Ion transporter that can act both as an ion channel and anion exchanger. Mainly acts as a chloride channel, which mediate uncoupled chloride anion transport in an alternate-access mechanism where a saturable binding site is alternately exposed to either one or the other side of the membrane. Also acts as a DIDS- and thiosulfate- sensitive anion exchanger the exchange of chloride for bicarbonate ions across the cell membrane.
messages: Membrane

8355:XB5951253.S
gene id: 8355:XB5951253.S
uniprot id: A0A8J1MF01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
messages: P-body

8355:LOC108708885
gene id: 8355:LOC108708885
uniprot id: A0A8J1MCU2
uniprot id: A0A8J1MEQ2
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

8355:tmem163.S
gene id: 8355:tmem163.S
uniprot id: A0A1L8ENP5
uniprot id: A0A974H1H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM163 family.
messages: Membrane
messages: synaptic vesicle membrane

8355:gins1.S
gene id: 8355:gins1.S
uniprot id: Q7ZT47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Chromosome
messages: Component of the GINS complex which is a heterotetramer of gins1/psf1, gins2/psf2, gins3/psf3 and gins4/sld5 (PubMed:12730133). Component of the CMG helicase complex, composed of the mcm2-7 complex, the GINS complex and cdc45 (PubMed:30979826, PubMed:30842657).
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

8355:dkk1.S
gene id: 8355:dkk1.S
uniprot id: A0A974HA10
uniprot id: O57464
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

8355:emc9.L
gene id: 8355:emc9.L
uniprot id: A0A974DZP5
uniprot id: Q3B8G2
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

8355:LOC108697267
gene id: 8355:LOC108697267
uniprot id: A0A8J1LEX8
uniprot id: A0A8J1LFV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes large subunit family.
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.
messages: coated pit

8355:mustn1.L
gene id: 8355:mustn1.L
uniprot id: Q05AX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MUSTANG family.
messages: Nucleus

8355:ccnyl1.S
gene id: 8355:ccnyl1.S
uniprot id: A0A974BUQ7
uniprot id: Q5U5D0
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

8355:LOC108699025
gene id: 8355:LOC108699025
uniprot id: A0A1L8FBG4
uniprot id: A0A974H8U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:grk7.S
gene id: 8355:grk7.S
uniprot id: A0A974CU88
uniprot id: B6CZ18
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Although the protein is present in a diversity of vertebrates ranging from bony fish to mammals, the mouse and rat orthologous proteins do not exist.
messages: Autophosphorylated in vitro at Ser-487 (By similarity). Phosphorylation at Ser-36 is regulated by light and activated by cAMP.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
messages: Membrane
messages: Retina, cones.
messages: Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).

8355:LOC121397723
gene id: 8355:LOC121397723
uniprot id: A0A8J1LP82
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:cope.S
gene id: 8355:cope.S
uniprot id: Q6GR46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPE family.
messages: Cytoplasm
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

8355:LOC121400429
gene id: 8355:LOC121400429
uniprot id: A0A8J1MCL2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:cyp27c1.L
gene id: 8355:cyp27c1.L
uniprot id: Q66IQ5
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:LOC398367
gene id: 8355:LOC398367
uniprot id: A0A8J0V6B1
uniprot id: A0A974E322
uniprot id: Q2VPG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

8355:LOC108697721
gene id: 8355:LOC108697721
uniprot id: A0A1L8FGK2
uniprot id: A0A974CDM7
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

8355:serpina6.L
gene id: 8355:serpina6.L
uniprot id: Q00387
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the serpin family.
messages: By estrogen.
messages: Liver.
messages: Not yet known.
messages: extracellular space

8355:LOC108700582
gene id: 8355:LOC108700582
uniprot id: A0A1L8F449
names: Similarity
messages: Belongs to the TAFA family.

8355:LOC108696815
gene id: 8355:LOC108696815
uniprot id: A0A8J1KNK6
names: Similarity
messages: Belongs to the Speedy/Ringo family.

8355:lrrc8d.L
gene id: 8355:lrrc8d.L
uniprot id: A0A1L8GMW1
uniprot id: A0A974HPH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

8355:wnt10a.S
gene id: 8355:wnt10a.S
uniprot id: A0A1L8ENU7
uniprot id: A0A974BU39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8355:ssbp2.S
gene id: 8355:ssbp2.S
uniprot id: A0A1L8HRA3
uniprot id: A0A8J0TQY4
uniprot id: A0A8J0TRZ4
uniprot id: A0A974I1W7
uniprot id: A0A974I254
uniprot id: A0A974I272
uniprot id: Q6NRV5
uniprot id: Q7ZYQ7
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108716206
gene id: 8355:LOC108716206
uniprot id: A0A1L8GA77
uniprot id: A0A8J1KPL2
uniprot id: A0A8J1KR83
uniprot id: A0A8J1KSR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

8355:gpr179.S
gene id: 8355:gpr179.S
uniprot id: A0A1L8EKP6
uniprot id: A0A8J1M001
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8355:arsa.2.L
gene id: 8355:arsa.2.L
uniprot id: A0A8J0UJG3
names: Similarity
messages: Belongs to the sulfatase family.

8355:crygbl.1.S
gene id: 8355:crygbl.1.S
uniprot id: A0A8J1LIE9
uniprot id: P55940
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Monomer.

8355:LOC108697678
gene id: 8355:LOC108697678
uniprot id: A0A1L8FGF7
uniprot id: A0A974CCC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0688 family.
messages: Nucleus

8355:b3gat1.S
gene id: 8355:b3gat1.S
uniprot id: A0A1L8FFI7
uniprot id: A0A8J0TCB9
uniprot id: A0A8J1LEW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:capn2.L
gene id: 8355:capn2.L
uniprot id: A0A1L8G6L2
uniprot id: Q6P415
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C2 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

8355:higd2a.L
gene id: 8355:higd2a.L
uniprot id: A0A974HSI6
uniprot id: Q63ZJ7
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

8355:mos.L
gene id: 8355:mos.L
uniprot id: P12965
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

8355:lgalsl.S
gene id: 8355:lgalsl.S
uniprot id: Q68FJ4
names: Caution
names: Function
messages: Does not bind lactose, and may not bind carbohydrates.
messages: Most of the residues in the galectin domain that have been shown to be critical for carbohydrate-binding in other galectins are not conserved.

8355:mau2.L
gene id: 8355:mau2.L
uniprot id: A0A8J1KQR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC4/mau-2 family.
messages: nucleoplasm

8355:corin.L
gene id: 8355:corin.L
uniprot id: A0A1L8HTN5
uniprot id: A0A8J0TJM4
uniprot id: A0A974DY92
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:znf687.S
gene id: 8355:znf687.S
uniprot id: A0A1L8F591
uniprot id: A0A974H6J6
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

8355:LOC108698976
gene id: 8355:LOC108698976
uniprot id: A0A8J1LHP2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8355:oxr1.L
gene id: 8355:oxr1.L
uniprot id: A0A1L8FZT0
uniprot id: A0A8J1KV02
uniprot id: A0A8J1KY04
uniprot id: A0A974CP58
uniprot id: B4F6Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXR1 family.
messages: May be involved in protection from oxidative damage.
messages: Mitochondrion

8355:copz1.L
gene id: 8355:copz1.L
uniprot id: A0A974DRI7
uniprot id: Q6GQG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

8355:caskin1.S
gene id: 8355:caskin1.S
uniprot id: A0A8J1LY20
uniprot id: A0A8J1LYY4
names: Subcellular Location Annotation
messages: Cytoplasm

8355:psmd11.S
gene id: 8355:psmd11.S
uniprot id: A0A1L8EL57
uniprot id: A0A974BSZ1
names: Similarity
messages: Belongs to the proteasome subunit S9 family.

8355:stmn2.L
gene id: 8355:stmn2.L
uniprot id: A0A974CQQ8
uniprot id: Q09001
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the stathmin family.
messages: Cytoplasm
messages: Membrane
messages: Nervous tissue.
messages: lamellipodium

8355:paics.1.L
gene id: 8355:paics.1.L
uniprot id: A0A1L8HTT3
uniprot id: A0A8J0VJA3
uniprot id: A0A8J1KKW5
uniprot id: Q8AVT1
names: Similarity
names: Subunit
messages: Homooctamer.
messages: In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.
messages: In the N-terminal section; belongs to the SAICAR synthetase family.

8355:iars1.S
gene id: 8355:iars1.S
uniprot id: A0A1L8GH96
uniprot id: Q6P284
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

8355:ddr2l.S
gene id: 8355:ddr2l.S
uniprot id: A0A1L8F0U0
uniprot id: A0A974C259
names: Subcellular Location Annotation
messages: Membrane

8355:gabarap.L
gene id: 8355:gabarap.L
uniprot id: Q6NUG7
names: Similarity
messages: Belongs to the ATG8 family.

8355:kcnc1.S
gene id: 8355:kcnc1.S
uniprot id: A0A8J1L9T0
uniprot id: A0A8J1LBC5
uniprot id: A0A8J1LC99
uniprot id: Q9PVD1
names: Subcellular Location Annotation
messages: Membrane

8355:mrpl12.L
gene id: 8355:mrpl12.L
uniprot id: A0A974H2P5
uniprot id: Q5U556
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

8355:pigg.S
gene id: 8355:pigg.S
uniprot id: A0A1L8HN52
uniprot id: A0A8J0UBK4
uniprot id: A0A974DSW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:LOC108698953
gene id: 8355:LOC108698953
uniprot id: A0A8J1LK16
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:tsc22d3.L
gene id: 8355:tsc22d3.L
uniprot id: Q7ZYC9
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

8355:LOC108709708
gene id: 8355:LOC108709708
uniprot id: A0A1L8H8M9
uniprot id: A0A974DIH7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Interacts with CHP1 and CHP2.
messages: Membrane

8355:slc44a5.L
gene id: 8355:slc44a5.L
uniprot id: A0A8J1MWN5
uniprot id: A0A8J1MWW7
uniprot id: A0A8J1MYB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

8355:LOC121402237
gene id: 8355:LOC121402237
uniprot id: A0A8J1MSM0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:blm.L
gene id: 8355:blm.L
uniprot id: A0A1L8H1D5
uniprot id: A0A974DF32
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

8355:LOC121399206
gene id: 8355:LOC121399206
uniprot id: A0A8J1M1M8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:tfap2d.L
gene id: 8355:tfap2d.L
uniprot id: A0A1L8GCC0
names: Similarity
messages: Belongs to the AP-2 family.

8355:LOC108705163
gene id: 8355:LOC108705163
uniprot id: A0A8J0U6U8
names: Subcellular Location Annotation
messages: Nucleus

8355:wnt3a.S
gene id: 8355:wnt3a.S
uniprot id: B7ZR66
uniprot id: P31285
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: At neurula in anterior neural fold; at tailbud in dorsal midline of midbrain.
messages: Belongs to the Wnt family.
messages: Disulfide bonds have critical and distinct roles in secretion and activity. Loss of each conserved cysteine results in high molecular weight oxidized Wnt oligomers, which are formed through inter-Wnt disulfide bonding.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube.
messages: Neurula onwards.
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Secreted
messages: extracellular matrix

8355:LOC108710455
gene id: 8355:LOC108710455
uniprot id: A0A8J0UGM5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:mapk14.S
gene id: 8355:mapk14.S
uniprot id: A0A8J0UHZ4
uniprot id: A0A974DGZ3
uniprot id: D2KW21
uniprot id: P47812
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
messages: Activated by tyrosine and threonine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Dually phosphorylated on Thr-181 and Tyr-183, which activates the enzyme.
messages: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. mapk14a is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. MPK2 is activated by upstream MAPKK/MAPKKK and stimulates MAPKAP kinase 2 to phosphorylate small heat shock proteins. Does not phosphorylate myelin basic protein or MAPKAP kinase 1.
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

8355:zpld1.S
gene id: 8355:zpld1.S
uniprot id: Q66IR0
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle membrane
messages: Glycoprotein which is a component of the gelatinous extracellular matrix in the cupulae of the vestibular organ.
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted form found in the extracellular matrix of the cupula.
messages: extracellular matrix

8355:atp6v0a1.L
gene id: 8355:atp6v0a1.L
uniprot id: A0A8J0TIV6
uniprot id: A0A8J0TQL4
uniprot id: A0A8J0TSM2
uniprot id: A0A8J0TTP8
uniprot id: A0A8J1LUT4
uniprot id: A0A8J1LW72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

8355:nr2e3.S
gene id: 8355:nr2e3.S
uniprot id: A0A1L8GTC1
uniprot id: A0A974D8E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

8355:LOC108699365
gene id: 8355:LOC108699365
uniprot id: A0A1L8FBX1
uniprot id: A0A8J0TMB7
uniprot id: A0A8J1LIU6
uniprot id: A0A974H8W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

8355:tcf19.S
gene id: 8355:tcf19.S
uniprot id: A0A1L8F3P5
uniprot id: A0A974C4S8
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108718600
gene id: 8355:LOC108718600
uniprot id: A0A8J1L1V7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:vps35.S
gene id: 8355:vps35.S
uniprot id: A0A974HLH8
uniprot id: Q5FWV1
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

8355:cdk2ap1.L
gene id: 8355:cdk2ap1.L
uniprot id: A0A1L8I1J6
uniprot id: A0A8J0VB85
uniprot id: A0A974E3K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDK2AP family.
messages: Nucleus

8355:tubgcp2.L
gene id: 8355:tubgcp2.L
uniprot id: A0A8J0T6B8
uniprot id: A0A8J0T8J6
uniprot id: A0A8J1L4I8
uniprot id: A0A8J1L688
uniprot id: A0A8J1L789
uniprot id: Q6DDJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome
messages: microtubule organizing center

8355:phf20l1.L
gene id: 8355:phf20l1.L
uniprot id: A0A8J0VI49
uniprot id: A0A8J0VKJ7
uniprot id: A0A8J0VKQ1
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108705066
gene id: 8355:LOC108705066
uniprot id: A0A310TQ91
uniprot id: A0A8J0TY81
uniprot id: A0A8J0U5C5
uniprot id: A0A8J0U6M9
uniprot id: A0A8J1L8K3
uniprot id: A0A974BRR4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:ccser1.L
gene id: 8355:ccser1.L
uniprot id: A0A1L8HV88
uniprot id: A0A974I361
names: Similarity
messages: Belongs to the CCSER family.

8355:fgf8.S
gene id: 8355:fgf8.S
uniprot id: A0A8J0TEP0
uniprot id: A0A8J0TFA6
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

8355:cep295.S
gene id: 8355:cep295.S
uniprot id: A0A310TND0
uniprot id: A0A974BQQ5
names: Subcellular Location Annotation
messages: centrosome

8355:cbr1.2.L
gene id: 8355:cbr1.2.L
uniprot id: A0A1L8HCI6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8355:cltrn.L
gene id: 8355:cltrn.L
uniprot id: Q6PE94
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:emx1.S
gene id: 8355:emx1.S
uniprot id: A0A1L8HKA3
uniprot id: A0A974HZS3
uniprot id: Q6AZM1
names: Subcellular Location Annotation
messages: Nucleus

8355:XB5756214.L
gene id: 8355:XB5756214.L
uniprot id: Q6AX04
names: Similarity
messages: Belongs to the MHC class I family.

8355:tfb1m.L
gene id: 8355:tfb1m.L
uniprot id: Q7T0W5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.
messages: Mitochondrion
messages: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA. Stimulates transcription independently of the methyltransferase activity (By similarity).

8355:LOC108712999
gene id: 8355:LOC108712999
uniprot id: A0A8J1MSI4
uniprot id: A0A8J1MTI6
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:opn6a.S
gene id: 8355:opn6a.S
uniprot id: A0A1L8G1Y4
uniprot id: A0A8J1KUB7
uniprot id: A0A974HHN9
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108696244
gene id: 8355:LOC108696244
uniprot id: A0A8J0TB19
uniprot id: A0A8J1L5E1
names: Subcellular Location Annotation
messages: Membrane

8355:tjp1.S
gene id: 8355:tjp1.S
uniprot id: A0A8J1MLN4
uniprot id: A0A8J1MLR4
uniprot id: A0A8J1MLR9
uniprot id: A0A8J1MMK5
uniprot id: A0A8J1MML1
uniprot id: A0A8J1MMN1
uniprot id: A0A8J1MNQ9
uniprot id: A0A8J1MNR6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

8355:acadm.L
gene id: 8355:acadm.L
uniprot id: A0A974D367
uniprot id: Q6DEB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Mitochondrion matrix

8355:grip2.L
gene id: 8355:grip2.L
uniprot id: A8E0R9
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the GRIP2 family.
messages: Cytoplasm
messages: Enriched in the mitochondrial cloud of stage I oocytes, before becoming concentrated at the tip of the vegetal cortex in stage II oocytes. Expression becomes localized to the germ plasm of stage III-IV oocytes and early cleavage stages. At the tailbud stage, localizes to the migrating primordial germ cells (PGCs) until PGC migration is complete (stage 40), at which point expression disappears. In the adult, expressed in the brain, ovary, eye, muscle, spinal cord and very weakly in adipocytes.
messages: Expressed maternally. Prominent in the egg and during early cleavage stages. Expression decreases slightly between neurula and late tailbud stage before elevating again at the tadpole stages.
messages: Plays an important role in primordial germ cell (PGC) maintenance and efficiency of PGC migration.

8355:capn10l.L
gene id: 8355:capn10l.L
uniprot id: A0A8J0V971
uniprot id: A0A8J0VE06
uniprot id: A0A8J1KLH2
uniprot id: A0A974HIR1
uniprot id: Q6DCQ4
names: Similarity
messages: Belongs to the peptidase C2 family.

8355:ndc80.L
gene id: 8355:ndc80.L
uniprot id: A0A1L8HBZ0
uniprot id: A0A974DMZ8
uniprot id: Q0IH25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

8355:epb42.S
gene id: 8355:epb42.S
uniprot id: A0A8J0TZL2
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.

8355:orc5.L
gene id: 8355:orc5.L
uniprot id: Q4V867
names: Subcellular Location Annotation
messages: Nucleus

8355:cbwd1.1.L
gene id: 8355:cbwd1.1.L
uniprot id: A0A1L8HY87
uniprot id: A0A974I4H6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:gna14.L
gene id: 8355:gna14.L
uniprot id: A0A8J1LQV2
uniprot id: A0A974E0N3
uniprot id: O73819
names: Function
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family. G(q) subfamily.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. Mediates responses to trypsin.

8355:poc1b.L
gene id: 8355:poc1b.L
uniprot id: Q4V7Z1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat POC1 family.
messages: Expressed in eggs and early stage embryos. Strong expression is maintained until stage 8.
messages: Highly expressed in ovary and, at low levels, in testis.
messages: Interacts with pat.
messages: Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control.
messages: centriole

8355:pkia.S
gene id: 8355:pkia.S
uniprot id: A0A1L8FTD4
uniprot id: A0A974CK54
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

8355:hrh4.g1.L
gene id: 8355:hrh4.g1.L
uniprot id: A0A1L8FYT7
uniprot id: A0A974CPQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108715220
gene id: 8355:LOC108715220
uniprot id: A0A8J1KHJ5
uniprot id: A0A8J1KHK0
uniprot id: A0A8J1KHK2
uniprot id: A0A8J1KHK5
uniprot id: A0A8J1KHK7
uniprot id: A0A8J1KHM1
uniprot id: A0A8J1KHM6
uniprot id: A0A8J1KJE4
uniprot id: A0A8J1KJE9
uniprot id: A0A8J1KKS6
uniprot id: A0A8J1KKS9
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

8355:pmpcb.L
gene id: 8355:pmpcb.L
uniprot id: A0A8J0UNF6
uniprot id: Q6IP51
names: Similarity
messages: Belongs to the peptidase M16 family.

8355:LOC108701845
gene id: 8355:LOC108701845
uniprot id: A0A1L8EW33
names: Subcellular Location Annotation
messages: Membrane

8355:itgb3.L
gene id: 8355:itgb3.L
uniprot id: A0A8J1LTS7
uniprot id: B7ZQZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

8355:cadm1.L
gene id: 8355:cadm1.L
uniprot id: A0A1L8FLM5
uniprot id: A0A8J0T8P9
uniprot id: A0A8J0T8S6
uniprot id: A0A8J1L4Q4
uniprot id: A0A974CFK6
uniprot id: Q5FWW6
names: Similarity
messages: Belongs to the nectin family.

8355:pex16.S
gene id: 8355:pex16.S
uniprot id: Q6INN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-16 family.
messages: Involved in peroxisome biogenesis.
messages: Peroxisome membrane

8355:prkab1.L
gene id: 8355:prkab1.L
uniprot id: A0A1L8I0A7
uniprot id: A0A8J1KY39
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

8355:meox2.S
gene id: 8355:meox2.S
uniprot id: Q7ZXL2
names: Subcellular Location Annotation
messages: Nucleus

8355:itm2a.S
gene id: 8355:itm2a.S
uniprot id: A0A974H664
uniprot id: Q7ZXQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

8355:cmc2.S
gene id: 8355:cmc2.S
uniprot id: A0A974HL98
uniprot id: A3KNE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

8355:LOC108710315
gene id: 8355:LOC108710315
uniprot id: A0A8J1MJ34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8355:foxc2.L
gene id: 8355:foxc2.L
uniprot id: A0A974D2L2
uniprot id: Q9PVY9
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: After the mid-blastula transition, expressed in the dorsolateral mesoderm but not within the dorsal blastopore lip. During gastrulation and neurulation, expressed within the dorsal mesoderm and the lateral border of the neural plate but not within the dorsal midline. In neurula stage embryos, expressed throughout the entire somite-forming mesoderm, at the border between mesoderm and ectoderm but not within the notochord, neuroectoderm or lateral plate mesoderm. From stage 25 to stage 32, expressed in branchial arches, head mesenchyme, neural crest cells, tail tip and in two segmented lines of cells bordering the somites. Tail tip expression persists throughout later development. From stage 32, expressed in the ventral abdominal muscle and around the spinal cord. Only weakly expressed in the pronephric tubules. At hatching, expressed within the heart, foregut, hindbrain and pharyngeal pouches.
messages: Expression begins after the mid-blastula transition (stage 8-8.5) becoming most abundant during gastrulation, then decreasing as development progresses. Expression remains at a very low level during the tailbud and tadpole stages.
messages: Nucleus
messages: Transcriptional activator (By similarity). May be involved in the dorso-ventral patterning of the mesoderm.

8355:abcc5.L
gene id: 8355:abcc5.L
uniprot id: A0A1L8GA45
uniprot id: A0A8J0VDI9
uniprot id: A0A8J1KPA1
uniprot id: A0A974CY31
names: Subcellular Location Annotation
messages: Membrane

8355:dync2li1.S
gene id: 8355:dync2li1.S
uniprot id: A0A1L8G1B7
uniprot id: A0A8J0VK74
uniprot id: A0A974CS01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light intermediate chain family.
messages: centrosome
messages: cilium
messages: cilium axoneme
messages: cilium basal body

8355:LOC108709739
gene id: 8355:LOC108709739
uniprot id: A0A8J1MEQ1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

8355:med15.S
gene id: 8355:med15.S
uniprot id: A0A8J0U1Y6
uniprot id: A0A8J0U905
uniprot id: A0A8J0UAB0
uniprot id: A0A8J1M3F0
uniprot id: A0A8J1M3F2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 15 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8355:sgpl1.L
gene id: 8355:sgpl1.L
uniprot id: A0A1L8FK37
uniprot id: A0A974HBK3
names: Similarity
messages: Belongs to the group II decarboxylase family.

8355:LOC108717512
gene id: 8355:LOC108717512
uniprot id: A0A8J0VF39
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:p2ry4.L
gene id: 8355:p2ry4.L
uniprot id: A0A974H749
uniprot id: Q7ZWQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108697611
gene id: 8355:LOC108697611
uniprot id: A0A1L8FG12
uniprot id: A0A974HAM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

8355:LOC108716289
gene id: 8355:LOC108716289
uniprot id: A0A8J0VEK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8355:cwc22.S
gene id: 8355:cwc22.S
uniprot id: Q52KN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC22 family.
messages: Component of the pre-catalytic spliceosome B and the catalytic spliceosome C complexes.
messages: Nucleus
messages: Nucleus speckle
messages: Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly.

8355:immt.S
gene id: 8355:immt.S
uniprot id: A0A1L8HKP3
uniprot id: A0A8J0U7M2
uniprot id: A0A974DTA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

8355:LOC108700280
gene id: 8355:LOC108700280
uniprot id: A0A1L8F400
uniprot id: A0A974C498
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8355:b3galt6.L
gene id: 8355:b3galt6.L
uniprot id: A0A1L8FM74
uniprot id: A0A974HCB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:tbx5.L
gene id: 8355:tbx5.L
uniprot id: A0A974E1R7
uniprot id: B7ZRZ7
uniprot id: Q9W7C2
names: Caution
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation (PubMed:10079235). May bind to the core DNA motif of promoters (By similarity).
messages: Expressed exclusively in the developing heart and eye. Expression begins within a subset of cardioblasts at neurula stages and continues within the heart during morphogenesis at later tadpole stages. Within the heart tube, expressed in all but the most anterior domain, the bulbus cordis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Homodimer (via the T-box); binds DNA as homodimer.
messages: Nucleus
messages: The T-Box domain binds to double-stranded DNA.

8355:itprip.L
gene id: 8355:itprip.L
uniprot id: A0A8J0T056
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Membrane

8355:LOC495229
gene id: 8355:LOC495229
uniprot id: A0A1L8HYY1
uniprot id: A0A8J1KTP0
uniprot id: A0A974I4K8
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

8355:LOC108701106
gene id: 8355:LOC108701106
uniprot id: A0A1L8EUD4
uniprot id: A0A974H2X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

8355:stum.S
gene id: 8355:stum.S
uniprot id: A0A1L8G0Z0
uniprot id: A0A974CRD1
names: Subcellular Location Annotation
messages: Membrane

8355:esr2.L
gene id: 8355:esr2.L
uniprot id: B2NIY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

8355:calr3.L
gene id: 8355:calr3.L
uniprot id: A0A1L8GME0
uniprot id: A0A974HPC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

8355:LOC121401070
gene id: 8355:LOC121401070
uniprot id: A0A8J1MJ12
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC108698336
gene id: 8355:LOC108698336
uniprot id: A0A1L8F712
uniprot id: A0A974C7N2
names: Similarity
messages: Belongs to the peptidase S1B family.

8355:LOC121402259
gene id: 8355:LOC121402259
uniprot id: A0A8J1MSM0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:snrnp35.L
gene id: 8355:snrnp35.L
uniprot id: Q05AT9
names: Subcellular Location Annotation
messages: Nucleus

8355:tmem184c.S
gene id: 8355:tmem184c.S
uniprot id: A0A1L8HLN2
uniprot id: A0A974I0K4
names: Subcellular Location Annotation
messages: Membrane

8355:plk3.L
gene id: 8355:plk3.L
uniprot id: A0A1L8GM50
uniprot id: A0A974D655
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

8355:c2orf49.L
gene id: 8355:c2orf49.L
uniprot id: A0A974DNJ1
uniprot id: Q9I8G4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ashwin family.
messages: Expressed both maternally and zygotically. Up-regulated in the neural ectoderm after the mid-gastrula stage.
messages: Expressed in the neural plate and later in the embryonic brain, eyes, and spinal cord.
messages: May regulate cell survival and anterior-posterior patterning.
messages: Nucleus

8355:LOC108711825
gene id: 8355:LOC108711825
uniprot id: A0A1L8H4D3
uniprot id: A0A974DFH5
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

8355:bdh1b.L
gene id: 8355:bdh1b.L
uniprot id: A0A1L8GA36
uniprot id: A0A8J0VCX7
uniprot id: A0A974HK13
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8355:zdhhc6.L
gene id: 8355:zdhhc6.L
uniprot id: A0A1L8FI51
uniprot id: A0A974CDL1
uniprot id: Q8AVN5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:fcho1.L
gene id: 8355:fcho1.L
uniprot id: A0A1L8HXQ9
uniprot id: A0A974I495
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FCHO family.
messages: clathrin-coated pit

8355:tat.L
gene id: 8355:tat.L
uniprot id: A0A1L8GKR9
uniprot id: A0A974D4G8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.

8355:LOC108698201
gene id: 8355:LOC108698201
uniprot id: A0A1L8F654
uniprot id: A0A974C5J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

8355:b2m.S
gene id: 8355:b2m.S
uniprot id: Q9IA97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-2-microglobulin family.
messages: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).
messages: Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).
messages: Secreted

8355:gapvd1.L
gene id: 8355:gapvd1.L
uniprot id: A0A1L8F6E5
uniprot id: A0A8J0TA23
uniprot id: A0A8J0TG64
uniprot id: A0A8J0TG69
uniprot id: A0A8J0THX6
uniprot id: A0A8J0THY1
uniprot id: A0A8J0TIP7
uniprot id: A0A8J0TIQ2
uniprot id: A0A8J0TJK6
uniprot id: A0A8J0TJL0
uniprot id: A0A8J1LHB4
uniprot id: A0A974H7H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAPVD1 family.
messages: Membrane

8355:krt59.S
gene id: 8355:krt59.S
uniprot id: A0A1L8HAC1
names: Similarity
messages: Belongs to the intermediate filament family.

8355:gfra2.S
gene id: 8355:gfra2.S
uniprot id: A0A8J1MRG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane

8355:slc35f1.L
gene id: 8355:slc35f1.L
uniprot id: A0A1L8G8X3
uniprot id: A0A974CVM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

8355:poglut3.L
gene id: 8355:poglut3.L
uniprot id: Q0IH54
names: Similarity
messages: Belongs to the KDELC family.

8355:timp2.S
gene id: 8355:timp2.S
uniprot id: Q6GLM1
names: Similarity
messages: Belongs to the protease inhibitor I35 (TIMP) family.

8355:cyrib.S
gene id: 8355:cyrib.S
uniprot id: A0A1L8FTU6
uniprot id: A0A8J0T7J0
uniprot id: A0A974CKM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYRI family.
messages: Membrane

8355:arih1.L
gene id: 8355:arih1.L
uniprot id: Q32NS4
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoinhibited by the ariadne domain, which masks the second RING-type zinc finger that contains the active site and inhibits the E3 activity. Inhibition is relieved upon binding to neddylated cullin-RING ubiquitin ligase complexes, which activate the E3 ligase activity of ARIH1.
messages: Belongs to the RBR family. Ariadne subfamily.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 ube2l3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes.
messages: Interacts (via the first RING-type zinc finger) with ube2l3. Associates with cullin-RING ubiquitin ligase (CRL) complexes containing neddylated cullin.
messages: Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING-type zinc finger, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved active site Cys residue in the second RING-type zinc finger. The active site probably forms a thioester intermediate with ubiquitin taken from the active-site cysteine of the E2 before ultimately transferring it to a Lys residue on the substrate.
messages: Nucleus
messages: The Ariadne domain inhibits activity by masking the second RING-type zinc finger that contains the active site.

8355:LOC108714442
gene id: 8355:LOC108714442
uniprot id: A0A1L8HY62
uniprot id: A0A8J0V351
uniprot id: A0A8J1KTN8
uniprot id: A0A8J1KTP3
uniprot id: A0A974I465
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

8355:myf6.S
gene id: 8355:myf6.S
uniprot id: A0A974DBF4
uniprot id: Q5U4S0
names: Subcellular Location Annotation
messages: Nucleus

8355:npl.S
gene id: 8355:npl.S
uniprot id: A0A1L8GG39
uniprot id: A0A974HLT5
names: Similarity
names: Subunit
messages: Belongs to the DapA family.
messages: Homotetramer.

8355:XB5870894.L
gene id: 8355:XB5870894.L
uniprot id: A0A1L8GBV3
uniprot id: A0A8J0VI84
uniprot id: A0A974CZ61
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:tiparp.S
gene id: 8355:tiparp.S
uniprot id: A0A1L8G4F7
uniprot id: A0A8J0VD70
uniprot id: A0A974HI26
names: Similarity
messages: Belongs to the ARTD/PARP family.

8355:abcg2.L
gene id: 8355:abcg2.L
uniprot id: A0A8J1M7G5
uniprot id: A0A974DZA3
uniprot id: A1L2M4
names: Subcellular Location Annotation
messages: Membrane

8355:sbk1l.L
gene id: 8355:sbk1l.L
uniprot id: A0A974CZA1
uniprot id: Q91758
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm

8355:catip.L
gene id: 8355:catip.L
uniprot id: Q0IHI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CATIP family.
messages: Cell membrane
messages: Cytoplasm
messages: Nucleus
messages: Plays a role in primary ciliogenesis by modulating actin polymerization.
messages: cytoskeleton

8355:tgif2.L
gene id: 8355:tgif2.L
uniprot id: A0A8J0U4E6
uniprot id: Q66J83
names: Subcellular Location Annotation
messages: Nucleus

8355:galnt1.S
gene id: 8355:galnt1.S
uniprot id: A0A8J1L0F6
uniprot id: A0A8J1L208
uniprot id: A0A8J1L381
uniprot id: Q6PA81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8355:cnksr1.L
gene id: 8355:cnksr1.L
uniprot id: A0A1L8HED5
uniprot id: A0A8J1M847
uniprot id: A0A8J1M9Y8
uniprot id: A0A974HXU8
names: Similarity
messages: Belongs to the CNKSR family.

8355:dpysl5.S
gene id: 8355:dpysl5.S
uniprot id: A0A1L8G5R4
uniprot id: A0A974HIN3
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

8355:LOC108698850
gene id: 8355:LOC108698850
uniprot id: A0A8J1LJG5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8355:hspa5.L
gene id: 8355:hspa5.L
uniprot id: A0A1L8F6I3
uniprot id: A0A974C5Z0
uniprot id: Q91883
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with dnajc10/ERdj5, probably to facilitate the release of dnajc10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by dnajb9/ERdj4 to the luminal region of ern1/ire1, leading to disrupt the dimerization of ern1/ire1, thereby inactivating ern1/ire1. Accumulation of misfolded protein in the endoplasmic reticulum causes release of hspa5/BiP from ern1/ire1, allowing homodimerization and subsequent activation of ern1/ire1 (By similarity).
messages: Endoplasmic reticulum lumen
messages: Monomer and homooligomer; homooligomerization via the interdomain linker inactivates the chaperone activity and acts as a storage of hspa5/BiP molecules (By similarity). Interacts with DNAJC10 (By similarity). Interacts with dnajb9/ERdj4; leading to recruit hspa5/BiP to ern1/ire1. Interacts with ern1/ire1; interaction takes place following interaction with dnajb9/ERdj4 and leads to inactivate ern1/IRE1 (By similarity).
messages: The chaperone activity is regulated by ATP-induced allosteric coupling of the nucleotide-binding (NBD) and substrate-binding (SBD) domains (By similarity). In the ADP-bound and nucleotide-free (apo) states, the two domains have little interaction (By similarity). In contrast, in the ATP-bound state the two domains are tightly coupled, which results in drastically accelerated kinetics in both binding and release of polypeptide substrates (By similarity). J domain-containing co-chaperones (dnajb9/ERdj4 or dnajc10/ERdj5) stimulate the ATPase activity and are required for efficient substrate recognition by hspa5/BiP. Homooligomerization inactivates participating hspa5/BiP protomers and probably act as reservoirs to store hspa5/BiP molecules when they are not needed by the cell (By similarity).
messages: The interdomain linker regulates the chaperone activity by mediating the formation of homooligomers. Homooligomers are formed by engagement of the interdomain linker of one hspa5/BiP molecule as a typical substrate of an adjacent hspa5/BiP molecule. hspa5/BiP oligomerization inactivates participating hspa5/BiP protomers. hspa5/BiP oligomers probably act as reservoirs to store hspa5/BiP molecules when they are not needed by the cell. When the levels of unfolded proteins rise, cells can rapidly break up these oligomers to make active monomers.

8355:bri3.L
gene id: 8355:bri3.L
uniprot id: A0A1L8EXX8
uniprot id: A0A974C0Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRI3 family.
messages: Membrane
messages: perinuclear region

8355:cks1b.L
gene id: 8355:cks1b.L
uniprot id: A3KMU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

8355:masp1.S
gene id: 8355:masp1.S
uniprot id: A0A8J1KR99
uniprot id: Q8AXR0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108713565
gene id: 8355:LOC108713565
uniprot id: A0A1L8GP20
uniprot id: A0A974D7J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Cell membrane
messages: Membrane

8355:rps27l.S
gene id: 8355:rps27l.S
uniprot id: A0A8J0UWY2
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

8355:ndrg2.S
gene id: 8355:ndrg2.S
uniprot id: A0A8J1LIX8
uniprot id: Q7ZY73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation (By similarity).
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.
messages: Cytoplasm

8355:map4k5.S
gene id: 8355:map4k5.S
uniprot id: A0A8J0PZN9
uniprot id: A0A8J1LNC0
uniprot id: Q68F04
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

8355:mrto4.S
gene id: 8355:mrto4.S
uniprot id: A0A1L8FHN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

8355:cnr1.L
gene id: 8355:cnr1.L
uniprot id: A0A1L8G9R5
uniprot id: A0A974CX79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for cannabinoids. Mediates many cannabinoid-induced effects in the central nervous system (CNS), as well as in peripheral tissues. Signaling typically involves reduction in cyclic AMP.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Presynapse
messages: Synapse
messages: axon

8355:ugt1a6.S
gene id: 8355:ugt1a6.S
uniprot id: A0A1L8EPI3
uniprot id: A0A974H1E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

8355:c18orf25.L
gene id: 8355:c18orf25.L
uniprot id: A0A8J0VJI2
uniprot id: A0A8J0VP47
uniprot id: Q7T0Y6
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108703381
gene id: 8355:LOC108703381
uniprot id: A0A8J0U1W6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

8355:sept5in.S
gene id: 8355:sept5in.S
uniprot id: A0A1L8HQF7
uniprot id: A0A8J0U2T1
uniprot id: A0A8J0U378
uniprot id: A0A8J0U383
uniprot id: A0A8J0U427
uniprot id: A0A974I1M5
uniprot id: A0A974I1W5
uniprot id: Q0VGX0
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

8355:cacng7.S
gene id: 8355:cacng7.S
uniprot id: A0A1L8FHA8
uniprot id: A0A974CD33
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2.

8355:cln5.L
gene id: 8355:cln5.L
uniprot id: A0A1L8HHC5
names: Similarity
messages: Belongs to the CLN5 family.

8355:eif4e1b.S
gene id: 8355:eif4e1b.S
uniprot id: A0A1L8HM93
uniprot id: A0A8J0TKX6
uniprot id: A0A8J0TTF3
uniprot id: A0A8J0TTG9
uniprot id: P48597
uniprot id: Q6AZE6
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic initiation factor 4E family.
messages: Cytoplasm
messages: Expressed both maternally and zygotically.
messages: Nucleus
messages: Recognizes and binds the 7-methylguanosine (m7G)-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:10635326). In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (By similarity). Maternal RNA in oocytes remain in a dormant state as tacc3/maskin outcompetes eif4g to bind eif4e, thereby preventing translation (PubMed:10635326). During oocyte maturation this complex dissolves and eif4g binds eif4e to allow translation of maternal RNAs (PubMed:10635326). Also promotes export of a subset of mRNAs from the nucleus to the cytoplasm (By similarity).
messages: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eif4a, eif4e and eif4g. eif4e is also known to interact with other partners (By similarity). tacc3/maskin competes with eif4g for binding to eif4e (PubMed:10635326).

8355:henmt1.L
gene id: 8355:henmt1.L
uniprot id: A0A1L8GNB2
uniprot id: A0A8J1MXP0
uniprot id: A0A8J1MYK6
uniprot id: A0A974HPD0
names: Similarity
messages: Belongs to the methyltransferase superfamily. HEN1 family.

8355:nudc.S
gene id: 8355:nudc.S
uniprot id: Q640C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudC family.
messages: Midbody
messages: spindle

8355:capn2.S
gene id: 8355:capn2.S
uniprot id: A0A1L8G117
uniprot id: A0A8J0VEB7
uniprot id: A0A974CQ53
names: Similarity
messages: Belongs to the peptidase C2 family.

8355:LOC108699806
gene id: 8355:LOC108699806
uniprot id: A0A1L8F0A9
uniprot id: A0A974C2F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8355:rspo2.S
gene id: 8355:rspo2.S
uniprot id: A0A8J1L305
names: Similarity
messages: Belongs to the R-spondin family.

8355:irf8.L
gene id: 8355:irf8.L
uniprot id: Q6DE53
names: Subcellular Location Annotation
messages: Nucleus

8355:mat2a.S
gene id: 8355:mat2a.S
uniprot id: A0A1L8GRZ7
uniprot id: A0A974HQK0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

8355:proser2.L
gene id: 8355:proser2.L
uniprot id: A0A1L8GZE7
uniprot id: A0A974DE29
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC121399435
gene id: 8355:LOC121399435
uniprot id: A0A8J1M4U0
names: Subcellular Location Annotation
messages: Nucleus

8355:arrdc1.S
gene id: 8355:arrdc1.S
uniprot id: A0A974C2H7
uniprot id: Q6AZP4
names: Similarity
messages: Belongs to the arrestin family.

8355:mettl3.L
gene id: 8355:mettl3.L
uniprot id: A0A974E1M9
uniprot id: Q6NUC3
names: Similarity
messages: Belongs to the MT-A70-like family.

8355:prdx1.S
gene id: 8355:prdx1.S
uniprot id: Q6GQB3
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

8355:p2rx5.L
gene id: 8355:p2rx5.L
uniprot id: A0A1L8HD30
uniprot id: A0A8J0UCH9
uniprot id: A0A974HXN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

8355:cox7a2l.L
gene id: 8355:cox7a2l.L
uniprot id: A0A8J0VAT2
uniprot id: Q2VPF0
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

8355:LOC121395566
gene id: 8355:LOC121395566
uniprot id: A0A8J1L6W5
names: Similarity
messages: Belongs to the Speedy/Ringo family.

8355:polg.L
gene id: 8355:polg.L
uniprot id: A0A1L8H0W3
uniprot id: A0A974HTH3
uniprot id: Q91684
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits.
messages: Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA (By similarity).
messages: Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.
messages: Mitochondrion
messages: mitochondrion nucleoid

8355:itga7.S
gene id: 8355:itga7.S
uniprot id: A0A1L8H9L0
uniprot id: A0A8J1MF25
uniprot id: A0A8J1MG08
uniprot id: A0A8J1MGW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

8355:LOC108709836
gene id: 8355:LOC108709836
uniprot id: A0A8J0UKA8
uniprot id: A0A8J0ULL9
names: Similarity
messages: Belongs to the TGF-beta family.

8355:mios.L
gene id: 8355:mios.L
uniprot id: A4QNS7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as a E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, MIOS is required to prevent autoubiquitination of WDR24, the catalytic subunit of the complex.
messages: Belongs to the WD repeat mio family.
messages: Component of the GATOR2 subcomplex, composed of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR2 complex interacts with CASTOR1 and CASTOR2; the interaction is negatively regulated by arginine. The GATOR2 complex interacts with SESN1, SESN2 and SESN3; the interaction is negatively regulated by amino acids.
messages: Lysosome membrane
messages: The GATOR2 complex is negatively regulated by the upstream amino acid sensors CASTOR1 and SESN2, which sequester the GATOR2 complex in absence of amino acids. In the presence of abundant amino acids, GATOR2 is released from CASTOR1 and SESN2 and activated.

8355:g6pc1.2.S
gene id: 8355:g6pc1.2.S
uniprot id: Q7ZXA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

8355:LOC121399027
gene id: 8355:LOC121399027
uniprot id: A0A1L8HPS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:brms1l.L
gene id: 8355:brms1l.L
uniprot id: A0A974C8R0
uniprot id: Q6AZT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRMS1 family.
messages: Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity.
messages: Nucleus

8355:foxo4.S
gene id: 8355:foxo4.S
uniprot id: A0A1L8F2C0
uniprot id: A0A974H5L7
names: Subcellular Location Annotation
messages: Nucleus

8355:tom1l2.L
gene id: 8355:tom1l2.L
uniprot id: Q68FJ8
names: Function
names: Similarity
names: Subunit
messages: Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures (By similarity). May also play a role in recruiting clathrin to endosomes (By similarity). May regulate growth factor-induced mitogenic signaling (By similarity).
messages: Belongs to the TOM1 family.
messages: Interacts with clathrin. Interacts with MYO6 (By similarity).

8355:fgfr4.S
gene id: 8355:fgfr4.S
uniprot id: Q9PSV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

8355:usp33.S
gene id: 8355:usp33.S
uniprot id: A0A8J0V5V1
uniprot id: A0A8J0V770
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: centrosome
messages: perinuclear region

8355:arrdc2.S
gene id: 8355:arrdc2.S
uniprot id: A0A1L8HN40
uniprot id: A0A974DVB3
uniprot id: Q08AZ2
names: Similarity
messages: Belongs to the arrestin family.

8355:rarres2.L
gene id: 8355:rarres2.L
uniprot id: A0A1L8FUQ9
uniprot id: A0A974HEU1
names: Subcellular Location Annotation
messages: Secreted

8355:LOC121393820
gene id: 8355:LOC121393820
uniprot id: A0A8J1KPX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Photoreceptor outer segment membrane

8355:myh11.S
gene id: 8355:myh11.S
uniprot id: A0A1L8EQ91
uniprot id: A0A8J0U156
uniprot id: A0A8J1M0H2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8355:ntf3.L
gene id: 8355:ntf3.L
uniprot id: A0A1L8GWP4
uniprot id: A0A974DAK4
uniprot id: P25435
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGF-beta family.
messages: Secreted
messages: Seems to promote the survival of visceral and proprioceptive sensory neurons.

8355:LOC108706519
gene id: 8355:LOC108706519
uniprot id: A0A1L8HKR8
uniprot id: A0A8J1M0R8
uniprot id: A0A974DRK6
names: Similarity
messages: Belongs to the lst-2 family.

8355:atp2b4.L
gene id: 8355:atp2b4.L
uniprot id: Q6DCT8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:trio.L
gene id: 8355:trio.L
uniprot id: A0A8J1KXT7
uniprot id: A0A8J1KXU2
uniprot id: A0A8J1KXU6
uniprot id: A0A8J1KXU7
uniprot id: A0A8J1KZF7
uniprot id: A0A8J1L0R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cell membrane
messages: Cytoplasm

8355:rabac1.S
gene id: 8355:rabac1.S
uniprot id: Q6NU63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

8355:LOC121393564
gene id: 8355:LOC121393564
uniprot id: A0A8J1KLY8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:gale.S
gene id: 8355:gale.S
uniprot id: A0A310UE35
uniprot id: A0A974BS05
uniprot id: Q6INX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
messages: Homodimer.

8355:LOC108713911
gene id: 8355:LOC108713911
uniprot id: A0A1L8GJQ6
uniprot id: A0A8J0V4R2
uniprot id: A0A974HN00
names: Similarity
messages: Belongs to the kindlin family.

8355:egfl8.S
gene id: 8355:egfl8.S
uniprot id: A0A1L8F3M2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:cacng8.S
gene id: 8355:cacng8.S
uniprot id: A0A1L8FHE1
uniprot id: A0A974CCY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits.

8355:stim1.S
gene id: 8355:stim1.S
uniprot id: A0A8J1MGT6
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108701898
gene id: 8355:LOC108701898
uniprot id: A0A8J1LRD0
uniprot id: A0A8J1LSY8
names: Caution
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: cilium membrane

8355:LOC108719345
gene id: 8355:LOC108719345
uniprot id: A0A1L8FZN4
uniprot id: A0A974HGI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 6c family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

8355:LOC108716965
gene id: 8355:LOC108716965
uniprot id: A0A1L8I158
uniprot id: A0A974I5M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

8355:jpt2.L
gene id: 8355:jpt2.L
uniprot id: Q6IR99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

8355:kcnq1.S
gene id: 8355:kcnq1.S
uniprot id: A0A1L8GD44
uniprot id: A0A974CYN5
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.1/KCNQ1 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum
messages: Lateral cell membrane
messages: Membrane
messages: Membrane raft

8355:brix1.L
gene id: 8355:brix1.L
uniprot id: A0A1L8I2K7
uniprot id: A0A974E411
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRX1 family.
messages: Required for biogenesis of the 60S ribosomal subunit.
messages: nucleolus

8355:clcn1.L
gene id: 8355:clcn1.L
uniprot id: A0A1L8FI02
names: Subcellular Location Annotation
messages: Membrane

8355:ibsp.S
gene id: 8355:ibsp.S
uniprot id: A0A1L8HME4
uniprot id: A0A974DSH1
names: Function
names: Subcellular Location Annotation
messages: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
messages: Secreted

8355:LOC108699502
gene id: 8355:LOC108699502
uniprot id: A0A1L8F5V6
uniprot id: A0A974C5M9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8355:recql5.L
gene id: 8355:recql5.L
uniprot id: A0A1L8EUG1
uniprot id: A0A974H3D5
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

8355:lamtor5.S
gene id: 8355:lamtor5.S
uniprot id: A0A974DHI0
uniprot id: Q6IRS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.
messages: Belongs to the LAMTOR5 family.
messages: Cytoplasm
messages: Lysosome
messages: Part of the Ragulator complex composed of lamtor1, lamtor2, lamtor3, lamtor4 and lamtor5. The Ragulator complex interacts with slc38a9; the probable amino acid sensor. Component of the lysosomal folliculin complex (LFC).

8355:bckdk.S
gene id: 8355:bckdk.S
uniprot id: Q6IRC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

8355:kcnk15.L
gene id: 8355:kcnk15.L
uniprot id: A0A1L8ES36
uniprot id: A0A974BWJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

8355:abhd1
gene id: 8355:abhd1
uniprot id: A0A8J1KR86
uniprot id: Q7ZWU0
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

8355:clcn1.S
gene id: 8355:clcn1.S
uniprot id: A0A8J1LB21
names: Subcellular Location Annotation
messages: Membrane

8355:st3gal2.2.S
gene id: 8355:st3gal2.2.S
uniprot id: A0A1L8EMP8
uniprot id: A0A8J0TXP2
uniprot id: A0A974H0T8
uniprot id: Q70D57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8355:slc26a9.S
gene id: 8355:slc26a9.S
uniprot id: A0A1L8H729
uniprot id: A0A8J0UC88
uniprot id: A0A974HVH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Ion transporter that can act both as an ion channel and anion exchanger. Mainly acts as a chloride channel, which mediate uncoupled chloride anion transport in an alternate-access mechanism where a saturable binding site is alternately exposed to either one or the other side of the membrane. Also acts as a DIDS- and thiosulfate- sensitive anion exchanger the exchange of chloride for bicarbonate ions across the cell membrane.
messages: Membrane

8355:LOC108710434
gene id: 8355:LOC108710434
uniprot id: A0A8J0USC6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108710399
gene id: 8355:LOC108710399
uniprot id: A0A8J1MIK9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:ghsr.L
gene id: 8355:ghsr.L
uniprot id: A0A8J0V8T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:sh2b3.L
gene id: 8355:sh2b3.L
uniprot id: A0A1L8I157
uniprot id: A0A974I5H5
names: Similarity
messages: Belongs to the SH2B adapter family.

8355:amotl1.L
gene id: 8355:amotl1.L
uniprot id: A0A8J0UBH1
uniprot id: A0A8J1M5X7
uniprot id: B1WBC7
names: Similarity
messages: Belongs to the angiomotin family.

8355:LOC121401424
gene id: 8355:LOC121401424
uniprot id: A0A1L8I041
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108718850
gene id: 8355:LOC108718850
uniprot id: A0A1L8I2Z4
uniprot id: A0A8J0VIY0
uniprot id: A0A974E4J6
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

8355:sh3bgr.S
gene id: 8355:sh3bgr.S
uniprot id: A0A8J0UBD1
uniprot id: A0A8J0UI23
uniprot id: A0A8J0UJC1
uniprot id: A0A8J1MCC8
uniprot id: A0A8J1MCU1
names: Similarity
messages: Belongs to the SH3BGR family.

8355:slc1a2.L
gene id: 8355:slc1a2.L
uniprot id: A0A1L8GIQ7
uniprot id: A0A8J0UZ58
uniprot id: A0A8J1MV06
uniprot id: A0A8J1MXG9
uniprot id: A0A974D3X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

8355:LOC108696764
gene id: 8355:LOC108696764
uniprot id: A0A1L8FNK6
uniprot id: A0A974CI87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

8355:yap1.S
gene id: 8355:yap1.S
uniprot id: Q32NJ6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YAP1 family.
messages: Cell junction
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated by lats1 and lats2; leading to cytoplasmic translocation and inactivation.
messages: Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation (By similarity).

8355:th.S
gene id: 8355:th.S
uniprot id: A0A8J1MZ24
uniprot id: A1KXR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
messages: axon
messages: perinuclear region

8355:rgma.S
gene id: 8355:rgma.S
uniprot id: A0A8J0UWB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

8355:LOC108697542
gene id: 8355:LOC108697542
uniprot id: A0A8J0TF31
uniprot id: A0A8J0TFR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsyntenin family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Postsynaptic cell membrane

8355:LOC108706921
gene id: 8355:LOC108706921
uniprot id: A0A8J0U9H9
names: Subcellular Location Annotation
messages: Nucleus

8355:slc16a10.S
gene id: 8355:slc16a10.S
uniprot id: A0A1L8G2P2
uniprot id: A0A974CR68
names: Subcellular Location Annotation
messages: Membrane

8355:siah1.S
gene id: 8355:siah1.S
uniprot id: A0A1L8GLB4
uniprot id: A0A974D5L4
uniprot id: A0A974HLY5
uniprot id: Q6GQJ5
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

8355:LOC108705318
gene id: 8355:LOC108705318
uniprot id: A0A8J0U776
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108703535
gene id: 8355:LOC108703535
uniprot id: A0A8J1MSS9
uniprot id: A0A8J1MST3
uniprot id: A0A8J1MSY6
uniprot id: A0A8J1MSZ1
uniprot id: A0A8J1MTV0
uniprot id: A0A8J1MU54
uniprot id: A0A8J1MU59
uniprot id: A0A8J1MV32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

8355:LOC108718348
gene id: 8355:LOC108718348
uniprot id: A0A1L8G5R3
uniprot id: A0A8J1KUW5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:satb1.L
gene id: 8355:satb1.L
uniprot id: A0A1L8FW95
uniprot id: A0A8J0VGF3
uniprot id: A0A8J0VJ26
uniprot id: A0A974CNE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

8355:LOC108705119
gene id: 8355:LOC108705119
uniprot id: A0A8J0TYD8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108716251
gene id: 8355:LOC108716251
uniprot id: A0A8J1KRZ1
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:nat8.6.S
gene id: 8355:nat8.6.S
uniprot id: Q9I8W5
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: At the beginning of gastrulation, expressed in deep cells of the presumptive mesoderm. At later gastrulation stages, expressed at the interface between already involuted and preinvoluted mesoderm. At late neurula and tailbud stages, expressed in the deep mass of cells lying ventrally and laterally to the closed blastopore.
messages: Belongs to the camello family.
messages: Expression is first detected after midblastula transition, reaches its maximum at stages 12-15 and continues to be expressed until at least stage 27.
messages: Golgi apparatus membrane
messages: Plays a role in regulation of gastrulation, possibly by controlled reduction of cell adhesion which is necessary for optimal cell motility.

8355:LOC121398743
gene id: 8355:LOC121398743
uniprot id: A0A8J1LYG6
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC108716476
gene id: 8355:LOC108716476
uniprot id: A0A1L8G6H3
uniprot id: A0A8J0VF28
names: Similarity
messages: Belongs to the peptidase C2 family.

8355:enpp1.L
gene id: 8355:enpp1.L
uniprot id: A0A8J0V7P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Secreted

8355:snx33.S
gene id: 8355:snx33.S
uniprot id: A0A974D8B2
uniprot id: Q6NRL2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking, both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes (By similarity).
messages: The PX and BAR domains mediate association with membranes and are required for membrane tubulation.
messages: cytosol

8355:htr7l.L
gene id: 8355:htr7l.L
uniprot id: A0A1L8HSI1
uniprot id: A0A974I2S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108695884
gene id: 8355:LOC108695884
uniprot id: A0A8J0T9Y3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108710176
gene id: 8355:LOC108710176
uniprot id: A0A8J1MIX7
uniprot id: A0A8J1MIZ5
uniprot id: A0A8J1MJM8
uniprot id: A0A8J1MJX4
uniprot id: A0A8J1MJY1
uniprot id: A0A8J1MKZ2
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with KCNJ11.
messages: Membrane

8355:zhx1.L
gene id: 8355:zhx1.L
uniprot id: A0A1L8G021
uniprot id: A0A974CP98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

8355:dusp3.L
gene id: 8355:dusp3.L
uniprot id: A0A1L8ETC6
uniprot id: A0A974BXE3
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

8355:LOC108704362
gene id: 8355:LOC108704362
uniprot id: A0A8J1MJZ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:tmpo.S
gene id: 8355:tmpo.S
uniprot id: A0A8J0UMB0
uniprot id: A0A8J0UT43
uniprot id: A0A8J0UUB6
uniprot id: A0A8J0UXM7
uniprot id: Q9YGK9
names: Similarity
messages: Belongs to the LEM family.

8355:ccdc56.L
gene id: 8355:ccdc56.L
uniprot id: A0A1L8ETS3
uniprot id: Q6GM33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COA3 family.
messages: Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.
messages: Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.
messages: Membrane
messages: Required for assembly of cytochrome c oxidase (complex IV).

8355:LOC108717678
gene id: 8355:LOC108717678
uniprot id: A0A8J1KV95
names: Similarity
messages: Belongs to the peptidase C2 family.

8355:ino80d.S
gene id: 8355:ino80d.S
uniprot id: A0A1L8EQ03
uniprot id: A0A8J0U0Z8
uniprot id: A0A974BUQ2
names: Subcellular Location Annotation
messages: Nucleus

8355:fer.S
gene id: 8355:fer.S
uniprot id: A0A1L8HR56
uniprot id: A0A8J1M3V5
uniprot id: A0A974DUV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: cytoskeleton

8355:LOC108708144
gene id: 8355:LOC108708144
uniprot id: A0A8J0UHD9
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Interacts with MAPK8IP2.

8355:atad2b.L
gene id: 8355:atad2b.L
uniprot id: A0A1L8GBQ6
uniprot id: A0A8J0V4C1
uniprot id: A0A8J0V7P6
uniprot id: A0A974CXR3
uniprot id: B1WBC6
names: Similarity
messages: Belongs to the AAA ATPase family.

8355:zdhhc23.L
gene id: 8355:zdhhc23.L
uniprot id: A0A1L8HBZ6
uniprot id: A0A974DKI6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:krt18.3.L
gene id: 8355:krt18.3.L
uniprot id: A0A974BYJ2
uniprot id: Q3KQ13
names: Similarity
messages: Belongs to the intermediate filament family.

8355:ssr4.L
gene id: 8355:ssr4.L
uniprot id: A0A1L8F6V7
uniprot id: A0A974C607
uniprot id: A0A974C7J6
uniprot id: Q66KW0
uniprot id: Q91868
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-delta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

8355:MGC115291
gene id: 8355:MGC115291
uniprot id: A0A1L8GUC7
uniprot id: A0A974D8L3
uniprot id: A0A974DAT8
uniprot id: Q52KN5
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

8355:LOC108701824
gene id: 8355:LOC108701824
uniprot id: A0A8J0TWJ7
names: Similarity
messages: Belongs to the ARTD/PARP family.

8355:marchf9.S
gene id: 8355:marchf9.S
uniprot id: A0A1L8H9V7
uniprot id: A0A974DK64
names: Subcellular Location Annotation
messages: Membrane

8355:cyp3a4.2.L
gene id: 8355:cyp3a4.2.L
uniprot id: A0A8J1KKW1
uniprot id: A0A974CXJ7
uniprot id: A2VD87
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:LOC121393639
gene id: 8355:LOC121393639
uniprot id: A0A1L8G742
uniprot id: A0A8J1KQU2
names: Similarity
messages: Belongs to the Speedy/Ringo family.

8355:il10.S
gene id: 8355:il10.S
uniprot id: A0A1L8H745
uniprot id: A0A974HVH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

8355:LOC108695644
gene id: 8355:LOC108695644
uniprot id: A0A1L8HZK7
uniprot id: A0A974I4N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:fam124b.S
gene id: 8355:fam124b.S
uniprot id: A0A1L8G4H2
uniprot id: A0A974CSF0
names: Similarity
messages: Belongs to the FAM124 family.

8355:LOC108707431
gene id: 8355:LOC108707431
uniprot id: A0A1L8HCX4
uniprot id: A0A8J1M7T6
names: Similarity
messages: Belongs to the band 7/mec-2 family.

8355:yju2.L
gene id: 8355:yju2.L
uniprot id: A0A1L8G899
uniprot id: A0A974CW94
uniprot id: Q66J68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC16 family. YJU2 subfamily.
messages: Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.
messages: Nucleus
messages: Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex.

8355:LOC108701067
gene id: 8355:LOC108701067
uniprot id: A0A1L8EU63
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8355:myh10.S
gene id: 8355:myh10.S
uniprot id: A0A1L8EN71
uniprot id: A0A8J1LVU6
uniprot id: A0A8J1LVX0
uniprot id: A0A974BTY8
uniprot id: Q04834
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8355:sptbn1.L
gene id: 8355:sptbn1.L
uniprot id: A0A1L8G5Y2
uniprot id: A0A8J0V9A0
uniprot id: A0A8J1KM44
uniprot id: A0A974CT89
names: Similarity
messages: Belongs to the spectrin family.

8355:LOC121401223
gene id: 8355:LOC121401223
uniprot id: A0A8J1MIC3
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:sncg.L
gene id: 8355:sncg.L
uniprot id: A0A1L8FK62
uniprot id: A0A974CET7
uniprot id: Q6INQ7
names: Similarity
names: Subunit
messages: Belongs to the synuclein family.
messages: May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation.

8355:snx21.L
gene id: 8355:snx21.L
uniprot id: A0A1L8ETW1
uniprot id: A0A8J0TTM9
uniprot id: A0A8J1LVY7
uniprot id: A0A974H2S4
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Membrane

8355:ppa1.L
gene id: 8355:ppa1.L
uniprot id: A0A1L8HUY4
uniprot id: A0A8J1MYH1
uniprot id: A0A974DZS0
names: Similarity
messages: Belongs to the PPase family.

8355:trmt44.L
gene id: 8355:trmt44.L
uniprot id: Q4KLT3
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRM44 family.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Cytoplasm
messages: Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.

8355:tbl3.L
gene id: 8355:tbl3.L
uniprot id: Q6PCE6
names: Subcellular Location Annotation
messages: nucleolus

8355:retreg1.S
gene id: 8355:retreg1.S
uniprot id: A0A1L8FS34
uniprot id: A0A8J1L216
uniprot id: A0A974CLH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:vps28.L
gene id: 8355:vps28.L
uniprot id: A0A1L8HBN1
names: Function
names: Similarity
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.

8355:LOC108707449
gene id: 8355:LOC108707449
uniprot id: A0A1L8HDH3
names: Subcellular Location Annotation
messages: Membrane

8355:vps28.S
gene id: 8355:vps28.S
uniprot id: A0A974DI89
uniprot id: Q7T0W4
names: Function
names: Similarity
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.

8355:ube2d3.S
gene id: 8355:ube2d3.S
uniprot id: A0A8J1M2S1
uniprot id: A0A8J1M3J5
uniprot id: A0A974I3E2
uniprot id: P62840
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53.
messages: Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex.

8355:mib1.L
gene id: 8355:mib1.L
uniprot id: Q6GNY1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors (By similarity).
messages: centriolar satellite

8355:LOC121397548
gene id: 8355:LOC121397548
uniprot id: A0A1L8F1H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

8355:LOC108717861
gene id: 8355:LOC108717861
uniprot id: A0A1L8G283
uniprot id: A0A974HHC0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the 40S small ribosomal subunit.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum
messages: cytosol

8355:ptx4.L
gene id: 8355:ptx4.L
uniprot id: A0A1L8EYU0
uniprot id: A0A974H4T0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:nadk.L
gene id: 8355:nadk.L
uniprot id: A0A8J0T8P0
uniprot id: A0A974CG31
uniprot id: Q32NQ6
names: Similarity
messages: Belongs to the NAD kinase family.

8355:LOC121399421
gene id: 8355:LOC121399421
uniprot id: A0A8J1KW79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

8355:dusp16.L
gene id: 8355:dusp16.L
uniprot id: A0A8J0U3V1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

8355:LOC121399105
gene id: 8355:LOC121399105
uniprot id: A0A1L8ENI5
uniprot id: A0A8J1LZJ7
names: Subcellular Location Annotation
messages: Membrane

8355:eda2r.L
gene id: 8355:eda2r.L
uniprot id: A0A8J0U473
uniprot id: A0A8J0U4U8
uniprot id: A0A8J1LGS6
uniprot id: A0A8J1LHN8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:en1.S
gene id: 8355:en1.S
uniprot id: A0A1L8ENE0
uniprot id: A0A974BUI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Engrailed homeobox family.
messages: Nucleus

8355:eri2.L
gene id: 8355:eri2.L
uniprot id: Q5HZL1
names: Cofactor
names: Similarity
messages: Belongs to the ERI2 family.
messages: Binds 2 magnesium ions per subunit.

8355:dsg2.L
gene id: 8355:dsg2.L
uniprot id: A0A1L8FYU6
uniprot id: A0A974HGK4
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: desmosome

8355:slc35a2.L
gene id: 8355:slc35a2.L
uniprot id: A0A8J0Q3Y8
uniprot id: Q32NP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8355:LOC108710768
gene id: 8355:LOC108710768
uniprot id: A0A1L8GWF5
uniprot id: A0A974D9V1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

8355:LOC121399839
gene id: 8355:LOC121399839
uniprot id: A0A8J1M992
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:KEF37 p05
gene id: 8355:KEF37_p05
uniprot id: P03904
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
messages: Mitochondrion inner membrane

8355:mpc1.S
gene id: 8355:mpc1.S
uniprot id: A0A8J0VAN8
uniprot id: A0A974HHA6
uniprot id: Q5M994
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

8355:LOC108708118
gene id: 8355:LOC108708118
uniprot id: A0A8J0UES2
names: Similarity
messages: Belongs to the JARID1 histone demethylase family.

8355:sema3f.L
gene id: 8355:sema3f.L
uniprot id: A0A1L8GP74
uniprot id: A0A8J0V7L6
uniprot id: A0A8J1MY37
uniprot id: A0A974D5R4
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108704304
gene id: 8355:LOC108704304
uniprot id: A0A8J0TWI5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:cyp3a5.L
gene id: 8355:cyp3a5.L
uniprot id: A0A1L8FWD2
uniprot id: A0A8J1KXL5
uniprot id: Q5U557
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:LOC121394455
gene id: 8355:LOC121394455
uniprot id: A0A8J1KXT3
names: Subcellular Location Annotation
messages: Membrane

8355:junb.S
gene id: 8355:junb.S
uniprot id: A0JMS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

8355:wscd1.S
gene id: 8355:wscd1.S
uniprot id: A0A1L8H658
uniprot id: A0A8J1MD32
uniprot id: A0A974DH04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WSCD family.
messages: Golgi apparatus membrane
messages: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.

8355:LOC121399829
gene id: 8355:LOC121399829
uniprot id: A0A8J1M8F4
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:fga.S
gene id: 8355:fga.S
uniprot id: Q7ZTR1
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

8355:LOC121399925
gene id: 8355:LOC121399925
uniprot id: A0A8J1M893
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:cdk14.L
gene id: 8355:cdk14.L
uniprot id: A0A1L8FVQ9
uniprot id: A0A8J1KWZ4
uniprot id: A0A8J1KWZ9
uniprot id: A0A8J1KYL6
uniprot id: A0A974HF75
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:ttyh1.S
gene id: 8355:ttyh1.S
uniprot id: A0A8J0TEC6
uniprot id: Q6GM04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

8355:pabpc4.L
gene id: 8355:pabpc4.L
uniprot id: A0A8J0UAT9
uniprot id: A0A8J1M6I4
uniprot id: A0A974DQA3
uniprot id: Q6GNR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

8355:slc30a4.S
gene id: 8355:slc30a4.S
uniprot id: A0A1L8GSV8
uniprot id: A0A974D764
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

8355:minar2.L
gene id: 8355:minar2.L
uniprot id: A0A8J0T8M7
names: Similarity
messages: Belongs to the MINAR family.

8355:LOC108700218
gene id: 8355:LOC108700218
uniprot id: A0A974C835
uniprot id: Q6NTT2
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Component of the small ribosomal subunit.

8355:p2rx7.L
gene id: 8355:p2rx7.L
uniprot id: A0A8J1LFI8
uniprot id: Q8UUP5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P2X receptor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

8355:tptep2-csnk1e.L
gene id: 8355:tptep2-csnk1e.L
uniprot id: A0A974D7I3
uniprot id: Q9PUI2
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:hbd.S
gene id: 8355:hbd.S
uniprot id: A0A974H1K2
uniprot id: P02137
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Red blood cells.
messages: This is a larval (tadpole) beta-globin.

8355:slco5a1.L
gene id: 8355:slco5a1.L
uniprot id: A0A1L8FZ80
uniprot id: A0A974HGA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

8355:LOC121401317
gene id: 8355:LOC121401317
uniprot id: A0A8J1MJR4
names: Subcellular Location Annotation
messages: Membrane

8355:mllt1.L
gene id: 8355:mllt1.L
uniprot id: A0A8J0U921
uniprot id: A0A8J0U936
uniprot id: A0A8J0UH46
uniprot id: A0A8J0UH62
uniprot id: Q68EY8
names: Subcellular Location Annotation
messages: Nucleus

8355:prdm5.L
gene id: 8355:prdm5.L
uniprot id: A0A8J0UN98
uniprot id: A0A8J0USK3
names: Subcellular Location Annotation
messages: Nucleus

8355:rnf126.L
gene id: 8355:rnf126.L
uniprot id: Q7T0Q3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates. Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome.
messages: Nucleus

8355:gpr55.S
gene id: 8355:gpr55.S
uniprot id: A0A1L8G4P7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:cpz.L
gene id: 8355:cpz.L
uniprot id: A0A8J1MQG6
uniprot id: A0A8J1MQK3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:lpar3.L
gene id: 8355:lpar3.L
uniprot id: A0A1L8GLP8
uniprot id: A0A974D5T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108709129
gene id: 8355:LOC108709129
uniprot id: A0A1L8H9S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted

8355:dnpep.S
gene id: 8355:dnpep.S
uniprot id: A0A8J1LW94
uniprot id: A0A974H160
uniprot id: Q5U4I5
names: Similarity
names: Subunit
messages: Belongs to the peptidase M18 family.
messages: Tetrahedron-shaped homododecamer built from six homodimers.

8355:ifitm1.S
gene id: 8355:ifitm1.S
uniprot id: A0A8J0V4M6
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8355:cnot7.S
gene id: 8355:cnot7.S
uniprot id: A0A974DTG0
uniprot id: Q3KQ85
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CAF1 family.
messages: Binds 2 divalent metal cations per subunit with RNAase activity being higher in presence of Mn(2+) than of Mg(2+) or Co(2+).
messages: Component of the CCR4-NOT complex.
messages: Cytoplasm
messages: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression.
messages: Nucleus

8355:LOC108701176
gene id: 8355:LOC108701176
uniprot id: A0A1L8EUR3
uniprot id: A0A974BYL0
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:plpp3.S
gene id: 8355:plpp3.S
uniprot id: A0A974CYY9
uniprot id: Q68F34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

8355:cpsf6.L
gene id: 8355:cpsf6.L
uniprot id: A0A1L8GYJ4
uniprot id: A0A8J0UII2
uniprot id: A0A8J0UPQ3
uniprot id: A0A8J0UQX7
uniprot id: A0A8J0UQY8
uniprot id: A0A8J0UQZ3
uniprot id: A0A8J0UU45
uniprot id: A0A8J0UU50
uniprot id: A0A974HSS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Nucleus

8355:men1.L
gene id: 8355:men1.L
uniprot id: B1H1W4
names: Subcellular Location Annotation
messages: Nucleus

8355:psap.S
gene id: 8355:psap.S
uniprot id: A0A8J0TE04
uniprot id: Q7SY70
names: Subcellular Location Annotation
messages: Secreted

8355:pan3.L
gene id: 8355:pan3.L
uniprot id: A0A1L8HJ05
uniprot id: A0A8J0UH97
uniprot id: A0A8J1MAG7
uniprot id: A0A974DQH0
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. PAN3 family.
messages: Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.
messages: Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PABPC1 (via PABC domain), conferring substrate specificity of the enzyme complex. Interacts with the GW182 family proteins TNRC6A, TNRC6B and TNRC6C.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: P-body
messages: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.
messages: The N-terminal zinc finger binds to poly(A) RNA.
messages: The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.

8355:LOC108695376
gene id: 8355:LOC108695376
uniprot id: A0A1L8HY64
uniprot id: A0A8J0T7A2
uniprot id: A0A8J1KQH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

8355:irf2.S
gene id: 8355:irf2.S
uniprot id: A0A974DS12
uniprot id: Q6DED7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Nucleus

8355:LOC108707447
gene id: 8355:LOC108707447
uniprot id: A0A8J1M9F4
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

8355:hebp1.L
gene id: 8355:hebp1.L
uniprot id: Q6NU05
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HEBP family.
messages: Cytoplasm
messages: Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel. Porphyrins are expected to bind to a hydrophobic patch on the outer surface of the beta-barrel structure (By similarity).
messages: May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities (By similarity).
messages: Monomer.

8355:igfbp4.L
gene id: 8355:igfbp4.L
uniprot id: A0A1L8ERV1
uniprot id: A0A974BWH1
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds IGF2 more than IGF1.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:slc12a8.L
gene id: 8355:slc12a8.L
uniprot id: A0A974BZB4
uniprot id: B7ZQQ7
uniprot id: Q6A4L1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cation/chloride cotransporter.
messages: Membrane

8355:LOC108716637
gene id: 8355:LOC108716637
uniprot id: A0A8J0VA53
names: Subcellular Location Annotation
messages: Membrane

8355:ocm4.4.S
gene id: 8355:ocm4.4.S
uniprot id: A0A1L8EQI3
uniprot id: A0A974BVQ1
uniprot id: Q6INW1
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

8355:mark3.L
gene id: 8355:mark3.L
uniprot id: A0A8J1LED8
uniprot id: A0A8J1LEE5
uniprot id: A0A8J1LEF0
uniprot id: A0A8J1LER6
uniprot id: A0A8J1LFV1
uniprot id: A0A8J1LFV6
uniprot id: A0A8J1LGU3
uniprot id: A0A8J1LGU8
uniprot id: Q804T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

8355:dock10.S
gene id: 8355:dock10.S
uniprot id: A0A8J0VIG8
uniprot id: A0A8J1KR31
uniprot id: A0A8J1KR52
uniprot id: A0A8J1KR58
uniprot id: A0A8J1KR59
uniprot id: A0A8J1KR63
uniprot id: A0A8J1KR73
uniprot id: A0A8J1KSQ6
uniprot id: A0A8J1KSR6
uniprot id: A0A8J1KU82
uniprot id: A0A8J1KU89
uniprot id: A0A8J1KU98
uniprot id: A8E5Y4
names: Similarity
messages: Belongs to the DOCK family.

8355:hbg2.S
gene id: 8355:hbg2.S
uniprot id: A0A974H1L4
uniprot id: Q6DKM5
names: Similarity
messages: Belongs to the globin family.

8355:gap43.S
gene id: 8355:gap43.S
uniprot id: A0A974DID6
uniprot id: P55860
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neuromodulin family.
messages: Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.
messages: Cell membrane
messages: Membrane
messages: Palmitoylated (By similarity). Palmitoylation is essential for plasma membrane association (By similarity).
messages: Palmitoylated. Palmitoylation is essential for plasma membrane association.
messages: Synapse
messages: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity).
messages: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
messages: filopodium membrane
messages: growth cone membrane

8355:spdyc.L
gene id: 8355:spdyc.L
uniprot id: Q9YGL1
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Speedy/Ringo family.
messages: Expressed both maternally and zygotically. Levels are constant from stage VI oocytes to the end of blastulation, decreasing at the onset of gastrulation and becoming undetectable at later stages.
messages: Interacts with cdk2. Interacts independently with cdk1 and with the cyclin B proteins ccnb1 and ccnb2, but doesn't interact with a cdc2-cyclin B complex. Prior to oocyte maturation, the mRNA is found in a complex with dazl and pum2 proteins; pum2 dissociates from the complex during maturation.
messages: Nucleus
messages: Stimulates oocyte maturation by promoting meiotic G2/M progression in resting oocytes, via activation of the MAPK cascade and cdc2-cyclin B. Also activates the kinase activity of cdk2; this activation does not appear necessary for oocyte maturation. Necessary for polyadenylation in oocytes.
messages: The C-terminus is required for CDK2-activation, but not CDK2-binding.

8355:alg6.S
gene id: 8355:alg6.S
uniprot id: A0A8J1N1E4
uniprot id: Q6DDK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:palm.S
gene id: 8355:palm.S
uniprot id: A0A8J0U8Z1
uniprot id: A0A8J0UBM9
names: Similarity
messages: Belongs to the paralemmin family.

8355:snapc3.S
gene id: 8355:snapc3.S
uniprot id: A0A8J0U9D2
uniprot id: A0A8J1M2X1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAPC3/SRD2 family.
messages: Nucleus
messages: Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.
messages: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

8355:scube1.S
gene id: 8355:scube1.S
uniprot id: A0A8J1MPS5
uniprot id: A0A8J1MPX3
uniprot id: A0A8J1MQT1
uniprot id: A0A8J1MQY5
uniprot id: A0A8J1MQZ4
uniprot id: A0A8J1MRZ7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:zic3.L
gene id: 8355:zic3.L
uniprot id: A0A1L8F822
uniprot id: A0A974H7T6
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

8355:LOC121401580
gene id: 8355:LOC121401580
uniprot id: A0A8J1MNB0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC121401331
gene id: 8355:LOC121401331
uniprot id: A0A8J1MIT8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:eif3i.S
gene id: 8355:eif3i.S
uniprot id: A0A1L8H828
uniprot id: A0A8J0UJC2
uniprot id: A0A974HW60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

8355:eif2s2.L
gene id: 8355:eif2s2.L
uniprot id: A0A974BXU5
uniprot id: Q6Q4H9
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

8355:papss1.L
gene id: 8355:papss1.L
uniprot id: Q498H6
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

8355:msrb1.L
gene id: 8355:msrb1.L
uniprot id: A0A8J0QGB5
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.

8355:LOC108711114
gene id: 8355:LOC108711114
uniprot id: A0A8J1N0E0
names: Subcellular Location Annotation
messages: Secreted

8355:kcnh4.S
gene id: 8355:kcnh4.S
uniprot id: A0A8J1LYW6
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

8355:arid1b.S
gene id: 8355:arid1b.S
uniprot id: A0A8J0VG82
uniprot id: A0A8J1KST7
uniprot id: A0A8J1KSU9
uniprot id: A0A8J1KSV0
uniprot id: A0A8J1KSV3
uniprot id: A0A8J1KUF6
uniprot id: A0A8J1KVW7
names: Subcellular Location Annotation
messages: Nucleus

8355:slc6a15.S
gene id: 8355:slc6a15.S
uniprot id: A0A1L8GUQ7
uniprot id: A0A974HRF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8355:LOC108709182
gene id: 8355:LOC108709182
uniprot id: A0A1L8H4V8
uniprot id: A0A974DFV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex.
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
messages: Membrane
messages: Mitochondrion inner membrane

8355:kcnj15.S
gene id: 8355:kcnj15.S
uniprot id: A0A1L8H5D5
uniprot id: A0A974DGM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

8355:gdf9.L
gene id: 8355:gdf9.L
uniprot id: A0A1L8GXJ0
uniprot id: A0A974DCV5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.
messages: Secreted

8355:foxl2.S
gene id: 8355:foxl2.S
uniprot id: B5BQ71
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC121401328
gene id: 8355:LOC121401328
uniprot id: A0A8J1MIS2
names: Subcellular Location Annotation
messages: Membrane

8355:pou5f3.3.L
gene id: 8355:pou5f3.3.L
uniprot id: Q91989
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the POU transcription factor family. Class-5 subfamily.
messages: Expressed in the animal half of oocytes and remains localized to the animal cap and marginal zone of blastula embryos. Expressed in the adult ovary and at a very low level in the adult kidney. Absent from primordial germ cells (PGCs).
messages: Expressed maternally. Most abundant in oocytes and fertilized eggs, with expression maintained through the cleavage stages of development until early gastrulation. Expression levels drop abruptly during gastrulation (stage 11) but remain at very low levels through larval stages.
messages: Interacts with the transcription factors tcf7l1/tcf3 and vegt.
messages: Nucleus
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Antagonizes the activity of nodal/activin signaling during gastrulation to suppress mesendoderm formation. Acts maternally to inhibit vegt and beta-catenin-activated gene transcription, probably by forming a transcriptional repression complex on the promoters of target genes. Binds to an octamer motif in interspersed RNA.

8355:LOC108704107
gene id: 8355:LOC108704107
uniprot id: A0A8J0U6N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:parp6.L
gene id: 8355:parp6.L
uniprot id: A0A8J1MLG1
uniprot id: A0A8J1MMC7
names: Similarity
messages: Belongs to the ARTD/PARP family.

8355:vac14.L
gene id: 8355:vac14.L
uniprot id: Q68F38
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VAC14 family.
messages: Endosome membrane
messages: Forms pentamers. Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold by pentamerizing into a star-shaped structure, which can bind a single copy each of PIKFYVE and FIG4 and coordinates their activities. Interacts with NOS1.
messages: Microsome membrane
messages: Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
messages: The C-terminal domain (residues 523-782) mediates pentameric interactions and is necessary for the formation and maintenance of the PI(3,5)P2 regulatory complex.

8355:ube2z.S
gene id: 8355:ube2z.S
uniprot id: Q6PCF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in apoptosis regulation.
messages: Cytoplasm
messages: Nucleus

8355:os9.S
gene id: 8355:os9.S
uniprot id: A0A1L8H9V6
uniprot id: A0A8J0UPP4
uniprot id: A0A974HWK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OS-9 family.
messages: Endoplasmic reticulum lumen
messages: Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.

8355:LOC108716695
gene id: 8355:LOC108716695
uniprot id: A0A1L8G7X4
uniprot id: A0A8J0VG11
uniprot id: A0A974HJB1
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8355:zmpste24.L
gene id: 8355:zmpste24.L
uniprot id: A0A1L8HFP4
uniprot id: A0A974HYJ4
uniprot id: Q640V5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

8355:LOC108716742
gene id: 8355:LOC108716742
uniprot id: A0A8J0VBX5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:hdac7.S
gene id: 8355:hdac7.S
uniprot id: A0A1L8H9Z7
uniprot id: A0A8J0UDU3
uniprot id: A0A8J0UKH3
uniprot id: A0A8J0UPQ9
uniprot id: A0A974HWF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

8355:crygdl.16.L
gene id: 8355:crygdl.16.L
uniprot id: A0A8J1MIN3
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:grb2.S
gene id: 8355:grb2.S
uniprot id: A0A1L8EMZ6
uniprot id: A0A8J0TQH5
uniprot id: A0A974H140
uniprot id: Q6GPJ9
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway (By similarity). Promotes meiotic reinitiation during oocyte maturation.
messages: Cytoplasm
messages: Endosome
messages: Golgi apparatus
messages: Nucleus
messages: The two SH3 domains and the SH2 domain are necessary for the reinitiation of oocyte meiosis.

8355:dna2.S
gene id: 8355:dna2.S
uniprot id: Q8QHA5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape fen1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit dna2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing (By similarity). Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. According to various reports, the helicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of dna2 on the flap, helping the nuclease function.
messages: Mitochondrion
messages: Nucleus

8355:LOC108707937
gene id: 8355:LOC108707937
uniprot id: A0A8J0UGF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

8355:lipt2.S
gene id: 8355:lipt2.S
uniprot id: A0A1L8HBD3
uniprot id: A0A974DLL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Mitochondrion

8355:pa2g4.S
gene id: 8355:pa2g4.S
uniprot id: A0A974DLA6
uniprot id: Q5U5C4
names: Similarity
messages: Belongs to the peptidase M24 family.

8355:axin1.L
gene id: 8355:axin1.L
uniprot id: A0A1L8EYQ2
uniprot id: A0A974C172
uniprot id: Q9YGY0
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: ADP-ribosylated by tankyrase tnks and tnks2. Poly-ADP-ribosylated protein is recognized by rnf146, followed by ubiquitination at 'Lys-48' and subsequent activation of the Wnt signaling pathway.
messages: Cell membrane
messages: Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway.
messages: Cytoplasm
messages: Homodimer (By similarity). Interacts with hwa; leading to promote the tankyrase-mediated degradation of axin1 (By similarity).
messages: Membrane
messages: Nucleus
messages: Ubiquitinated by rnf146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway.
messages: Weakly and ubiquitously expressed throughout early development, and highly expressed in the anterior mesencephalon adjacent to the forebrain-midbrain boundary.

8355:sec24c.S
gene id: 8355:sec24c.S
uniprot id: Q641I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

8355:cmtr1.L
gene id: 8355:cmtr1.L
uniprot id: A0A1L8G6Y2
uniprot id: A0A8J0VAB5
uniprot id: A0A974CVJ4
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.

8355:LOC108711401
gene id: 8355:LOC108711401
uniprot id: A0A1L8H0L0
uniprot id: A0A8J0UR48
uniprot id: A0A8J1MLS7
uniprot id: A0A974DFE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

8355:LOC108717125
gene id: 8355:LOC108717125
uniprot id: A0A1L8GBE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Membrane

8355:pno1.L
gene id: 8355:pno1.L
uniprot id: A0A974CTU7
uniprot id: Q8AVH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNO1 family.
messages: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA.
messages: nucleolus

8355:LOC108708444
gene id: 8355:LOC108708444
uniprot id: A0A1L8HGX5
uniprot id: A0A8J0UEL8
uniprot id: A0A8J0UG44
uniprot id: A0A974DPV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

8355:ptges.L
gene id: 8355:ptges.L
uniprot id: A0A8J0U5Z5
uniprot id: A0A8J1LFV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

8355:flvcr1.S
gene id: 8355:flvcr1.S
uniprot id: A0A8J0VEF0
uniprot id: A0A8J0VFN8
names: Subcellular Location Annotation
messages: Membrane

8355:tcp11l2.L
gene id: 8355:tcp11l2.L
uniprot id: A0A1L8GY49
uniprot id: A0A8J0UQM0
uniprot id: A0A974HSX7
names: Similarity
messages: Belongs to the TCP11 family.

8355:LOC108719241
gene id: 8355:LOC108719241
uniprot id: A0A1L8FYX6
uniprot id: A0A8J1KYG3
uniprot id: A0A974CNJ5
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

8355:LOC108707775
gene id: 8355:LOC108707775
uniprot id: A0A1L8HBX4
uniprot id: A0A974HXH5
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
messages: Belongs to the complex I NDUFV3 subunit family.
messages: Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

8355:dzip1.L
gene id: 8355:dzip1.L
uniprot id: A0A8J0U411
uniprot id: A0A8J0U415
uniprot id: A0A8J0UAZ8
uniprot id: A0A8J0UC77
uniprot id: A0A8J0UC81
uniprot id: A0A8J0UCA2
uniprot id: A0A8J0UEW1
uniprot id: A0A8J1M6M1
uniprot id: A0A8J1M7D9
uniprot id: Q6DCV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DZIP C2H2-type zinc-finger protein family.
messages: cilium basal body

8355:rcl1.S
gene id: 8355:rcl1.S
uniprot id: Q2NLA9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: nucleolus

8355:LOC108699250
gene id: 8355:LOC108699250
uniprot id: A0A1L8FAX8
uniprot id: A0A974H8P1
names: Similarity
messages: Belongs to the globin family.

8355:LOC108716640
gene id: 8355:LOC108716640
uniprot id: A0A8J0V739
uniprot id: A0A8J0VA58
uniprot id: A0A8J0VBG8
uniprot id: A0A8J0VFP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

8355:mix1.S
gene id: 8355:mix1.S
uniprot id: A0A974HHC4
uniprot id: P21711
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the paired homeobox family.
messages: By activin and TGF-beta1 (immediate early response gene).
messages: Expressed mostly in the presumptive endodermal cells of Xenopus embryos.
messages: Nucleus
messages: Transcription factor which plays a regulatory role in the development of the embryo. Involved in the establishment of dorsal/ventral pattern in the early mesoderm. Activates the head organizer gene cer1 by acting synergistically with otx2 and siamois through the 5'-TAATCT-3' element of the cer1 promoter. Also binds as a complex with lhx1/lim1 and siamois to the 3x 5'-TAAT-3' element of the cer1 promoter.

8355:rabggta.L
gene id: 8355:rabggta.L
uniprot id: A0A1L8HYM5
uniprot id: A0A8J1M598
uniprot id: A0A974E124
uniprot id: Q6DDV4
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.

8355:eva1b.S
gene id: 8355:eva1b.S
uniprot id: A0A1L8H7R0
uniprot id: A0A974HVZ1
names: Similarity
messages: Belongs to the EVA1 family.

8355:LOC108710963
gene id: 8355:LOC108710963
uniprot id: A0A8J0UHW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

8355:ipmk.L
gene id: 8355:ipmk.L
uniprot id: Q66J00
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

8355:arrdc3.L
gene id: 8355:arrdc3.L
uniprot id: A0A1L8I1T8
uniprot id: A0A8J1L693
uniprot id: A0A974E2D7
names: Similarity
messages: Belongs to the arrestin family.

8355:LOC108710052
gene id: 8355:LOC108710052
uniprot id: A0A1L8HBA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

8355:crhr2.L
gene id: 8355:crhr2.L
uniprot id: A0A1L8FV17
uniprot id: A0A8J1KY88
uniprot id: A0A974HEW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Membrane

8355:alkbh5.L
gene id: 8355:alkbh5.L
uniprot id: A0A1L8EYM3
uniprot id: A0A974H4D2
names: Subcellular Location Annotation
names: Subunit
messages: Monomer.
messages: Nucleus speckle

8355:agxt.L
gene id: 8355:agxt.L
uniprot id: A0A974HJZ8
uniprot id: Q9DEN7
names: Similarity
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

8355:LOC108707613
gene id: 8355:LOC108707613
uniprot id: A0A8J1MB42
names: Caution
names: Cofactor
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:rps12.S
gene id: 8355:rps12.S
uniprot id: A0A8J1KRA0
uniprot id: Q6PH94
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

8355:rida.L
gene id: 8355:rida.L
uniprot id: A0A974CP23
uniprot id: Q6NTT0
names: Function
names: Similarity
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.

8355:echdc1.L
gene id: 8355:echdc1.L
uniprot id: A0A974HJ91
uniprot id: Q5HZQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Acts preferentially on (S)-ethylmalonyl-CoA but has also some activity on the (R)-isomer. Also has methylmalonyl-CoA decarboxylase activity at lower level.
messages: cytosol

8355:ccnj.L
gene id: 8355:ccnj.L
uniprot id: A0A1L8FJ67
uniprot id: A0A974HBA1
names: Similarity
messages: Belongs to the cyclin family.

8355:LOC443712
gene id: 8355:LOC443712
uniprot id: A0A1L8HC74
uniprot id: A0A974DMC2
uniprot id: A4FVD6
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108700830
gene id: 8355:LOC108700830
uniprot id: A0A8J0TKC5
uniprot id: A0A8J0TSW9
names: Similarity
messages: Belongs to the RUNDC3 family.

8355:krtcap2.L
gene id: 8355:krtcap2.L
uniprot id: A0A8J0TDV5
uniprot id: A0A8J0THC7
uniprot id: A0A974H9T3
uniprot id: A5D8P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRTCAP2 family.
messages: Membrane

8355:XB5994047.L
gene id: 8355:XB5994047.L
uniprot id: A0A1L8GJP3
uniprot id: A0A974D1U4
names: Similarity
messages: Belongs to the aldo/keto reductase family.

8355:kat7.S
gene id: 8355:kat7.S
uniprot id: A0A1L8EL06
uniprot id: A0A8J1LXA3
uniprot id: A0A8J1LXA5
uniprot id: A0A8J1LXA6
uniprot id: A0A8J1LXA9
uniprot id: A0A8J1LXM5
uniprot id: A0A8J1LZI1
uniprot id: Q6AZV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

8355:rbx1.S
gene id: 8355:rbx1.S
uniprot id: A0A1L8GGS6
uniprot id: A0A974D103
names: Similarity
messages: Belongs to the RING-box family.

8355:mpdu1.S
gene id: 8355:mpdu1.S
uniprot id: Q32NW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPDU1 (TC 2.A.43.3) family.
messages: Membrane

8355:b3gat1l.L
gene id: 8355:b3gat1l.L
uniprot id: A0A974DKP5
uniprot id: Q63ZM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:bysl.S
gene id: 8355:bysl.S
uniprot id: Q6INQ1
names: Similarity
messages: Belongs to the bystin family.

8355:ldlrad4.L
gene id: 8355:ldlrad4.L
uniprot id: A0A1L8FYE7
uniprot id: A0A8J1KZW7
uniprot id: A0A8J1L158
uniprot id: A0A974HG34
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:b4galt2.S
gene id: 8355:b4galt2.S
uniprot id: A0A8J0UZ55
uniprot id: B5DE62
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

8355:cadps.L
gene id: 8355:cadps.L
uniprot id: Q6GLR7
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) (By similarity).
messages: Homodimer.
messages: Synapse
messages: The PH domain is essential for regulated exocytosis and binds phospholipids.
messages: neuronal dense core vesicle membrane

8355:exoc2.L
gene id: 8355:exoc2.L
uniprot id: A0A1L8FXQ8
uniprot id: A0A974CMZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Component of the exocyst complex.
messages: Nucleus

8355:LOC108701771
gene id: 8355:LOC108701771
uniprot id: A0A8J1LRS1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

8355:lmf2.S
gene id: 8355:lmf2.S
uniprot id: A0A8J1MRA6
uniprot id: A0A8J1MSK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lipase maturation factor family.
messages: Endoplasmic reticulum membrane
messages: Involved in the maturation of specific proteins in the endoplasmic reticulum.
messages: Membrane

8355:LOC121394475
gene id: 8355:LOC121394475
uniprot id: A0A8J1KW89
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:foxm1.S
gene id: 8355:foxm1.S
uniprot id: A0A8J0UUS4
uniprot id: Q5W1J6
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed both maternally and zygotically. Maternal levels decrease rapidly until the blastula stage. Absent from gastrula stage embryos and then zygotic expression starts during neurulation and persists until the end of organogenesis.
messages: Localized to the animal hemisphere of early cleavage stage embryos. During neurulation, expressed in the neural folds. Later, expressed in the spinal cord and in the eye field. During tailbud stages, expression is still restricted to the neuroectoderm, predominantly to the hindbrain, the eye and the spinal cord. With ongoing development, expression is also found at lower levels in the branchial arches. At stage 35, expressed in the rhombencephalon and in the eye retina.
messages: Nucleus
messages: Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Also plays a role in DNA break repair, participating in the DNA damage checkpoint response. Promotes transcription of PHB2.

8355:parp11.S
gene id: 8355:parp11.S
uniprot id: A0A1L8GQV4
uniprot id: A0A8J1MRB3
uniprot id: A0A974D674
uniprot id: Q6DDP4
names: Similarity
messages: Belongs to the ARTD/PARP family.

8355:usp39.S
gene id: 8355:usp39.S
uniprot id: A0A8J0UUX6
names: Subcellular Location Annotation
messages: Nucleus

8355:ezr.L
gene id: 8355:ezr.L
uniprot id: A0A974CXG1
uniprot id: Q6AX84
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

8355:fyttd1.S
gene id: 8355:fyttd1.S
uniprot id: A0A8J0VJA8
uniprot id: A0A8J1KRS2
uniprot id: A0A974HHV5
uniprot id: Q4V7Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UIF family.
messages: Nucleus speckle
messages: Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the ddx39b/uap56-nfx1 pathway to ensure efficient mRNA export and delivering to the nuclear pore (By similarity).
messages: nucleoplasm

8355:tmem147.L
gene id: 8355:tmem147.L
uniprot id: A0A1L8FPF0
uniprot id: A0A974CJP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM147 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:rbp1.L
gene id: 8355:rbp1.L
uniprot id: Q6NU58
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

8355:LOC108713678
gene id: 8355:LOC108713678
uniprot id: A0A1L8GP80
uniprot id: A0A8J1MUS9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natural cytotoxicity receptor (NCR) family.
messages: Cell membrane
messages: Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6.
messages: Membrane

8355:a2m.S
gene id: 8355:a2m.S
uniprot id: A0A8J0QF15
uniprot id: B2GTX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8355:amz2.L
gene id: 8355:amz2.L
uniprot id: A0A1L8EUX6
uniprot id: A0A8J1LUQ8
names: Function
names: Similarity
messages: Belongs to the peptidase M54 family.
messages: Probable zinc metalloprotease.

8355:ebf2.L
gene id: 8355:ebf2.L
uniprot id: A0A8J1MGZ2
uniprot id: A0A974HU02
uniprot id: B7ZRI2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the COE family.
messages: Expression begins during primary neurogenesis at the neural plate stage (stage 12) and accumulates at the tailbud stage. Expressed after neurog2/X-ngnr-1 and before neurod1. Also expressed in adults.
messages: In embryos, expressed in precursors of primary neurons. In adults, expressed at high levels in the brain, and at low levels in the somatic muscles, testis, and possibly the spleen.
messages: May play a pivotal role in the transcriptional cascade that specifies primary neurons in embryos. Stabilizes the higher neural potential of selected progenitor cells that express neurog2/X-ngnr-1 by maintaining Delta-Notch signaling. Thus ensures the transition between neural competence and irreversible commitment to a neural fate. Also promotes neuronal differentiation by activating neurod1 expression, directly or indirectly.
messages: Nucleus

8355:tbx21.L
gene id: 8355:tbx21.L
uniprot id: A0A1L8ES01
uniprot id: A0A974BW71
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8355:atp1a1.L
gene id: 8355:atp1a1.L
uniprot id: A0A1L8HBQ3
uniprot id: A0A974HX82
uniprot id: Q92123
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.
messages: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
messages: sarcolemma

8355:avl9.L
gene id: 8355:avl9.L
uniprot id: A0A1L8FWU4
uniprot id: A0A974CNU2
names: Subcellular Location Annotation
messages: Recycling endosome

8355:tipin.S
gene id: 8355:tipin.S
uniprot id: Q6GPS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSM3 family.
messages: Nucleus
messages: Plays an important role in the control of DNA replication and the maintenance of replication fork stability.

8355:LOC108716419
gene id: 8355:LOC108716419
uniprot id: A0A1L8G623
uniprot id: A0A974HIS5
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108695909
gene id: 8355:LOC108695909
uniprot id: A0A1L8FNM8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:MGC64462
gene id: 8355:MGC64462
uniprot id: A0A8J1LE64
uniprot id: B7ZRF4
uniprot id: Q7SYV5
names: Similarity
messages: Belongs to the DNase I family.

8355:jpt1.L
gene id: 8355:jpt1.L
uniprot id: A0A1L8EUH3
uniprot id: A0A974H3G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

8355:fgd6.S
gene id: 8355:fgd6.S
uniprot id: A0A1L8GUJ3
uniprot id: A0A974DBB8
names: Subcellular Location Annotation
messages: cytoskeleton

8355:LOC108708898
gene id: 8355:LOC108708898
uniprot id: A0A8J0UAR6
uniprot id: A0A8J1MD67
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.
messages: NAD-dependent protein deacetylase.

8355:atp6v0a4.L
gene id: 8355:atp6v0a4.L
uniprot id: Q6PA83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

8355:rpl27.L
gene id: 8355:rpl27.L
uniprot id: A0A1L8ETY8
uniprot id: A0A974H2Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL27 family.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum

8355:nsun7.L
gene id: 8355:nsun7.L
uniprot id: B1H1T1
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108702811
gene id: 8355:LOC108702811
uniprot id: A0A8J1KI20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:cd74.L
gene id: 8355:cd74.L
uniprot id: A0A1L8GWN9
uniprot id: A0A974DCK6
uniprot id: A0A974HS35
uniprot id: Q6PB08
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:adcyap1.S
gene id: 8355:adcyap1.S
uniprot id: A0A1L8FSR7
uniprot id: A0A8J0T7P7
uniprot id: A0A974HE55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

8355:rnf43.L
gene id: 8355:rnf43.L
uniprot id: A0A8J0U5X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZNRF3 family.
messages: Cell membrane

8355:fam13a.S
gene id: 8355:fam13a.S
uniprot id: A0A8J0U7L9
uniprot id: A0A8J1M1Q8
uniprot id: A0A8J1M1R3
uniprot id: A0A8J1M2T6
uniprot id: A0A8J1M3L0
uniprot id: A0A8J1M3L4
names: Similarity
messages: Belongs to the FAM13 family.

8355:sulf1.L
gene id: 8355:sulf1.L
uniprot id: A0A1L8FZC3
uniprot id: A0A8J0VHR3
uniprot id: A0A974HGE6
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

8355:eaf1.S
gene id: 8355:eaf1.S
uniprot id: A0A1L8FRN7
uniprot id: A0A8J1L1Q3
uniprot id: A0A974CJG5
names: Similarity
messages: Belongs to the EAF family.

8355:enkur.L
gene id: 8355:enkur.L
uniprot id: A0A974HF53
uniprot id: Q5PQ29
names: Subcellular Location Annotation
messages: cilium axoneme

8355:impa1.S
gene id: 8355:impa1.S
uniprot id: Q6GM60
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

8355:LOC108697860
gene id: 8355:LOC108697860
uniprot id: A0A8J1LDU0
names: Similarity
messages: Belongs to the FAM131 family.

8355:aldh7a1.S
gene id: 8355:aldh7a1.S
uniprot id: A0A1L8HR02
uniprot id: A0A974DUR9
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.

8355:LOC108695732
gene id: 8355:LOC108695732
uniprot id: A0A1L8FIL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108718785
gene id: 8355:LOC108718785
uniprot id: A0A1L8FVI9
uniprot id: A0A974CNP3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:ndst1.S
gene id: 8355:ndst1.S
uniprot id: A0A974D6Y8
uniprot id: Q6GQK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate.
messages: Golgi apparatus membrane
messages: Membrane
messages: Monomer.
messages: trans-Golgi network membrane

8355:h2ac17.L
gene id: 8355:h2ac17.L
uniprot id: A0A974DL79
uniprot id: Q6PH89
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:LOC121393141
gene id: 8355:LOC121393141
uniprot id: A0A8J1LGP8
names: Similarity
messages: Belongs to the SUA5 family.

8355:sh3pxd2a.L
gene id: 8355:sh3pxd2a.L
uniprot id: A0A1L8FJA0
uniprot id: A0A8J0T7G8
uniprot id: A0A8J1L4W9
uniprot id: A0A8J1L4X1
uniprot id: A0A8J1L6N5
uniprot id: A0A8J1L7N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SH3PXD2 family.
messages: Cytoplasm

8355:LOC121401335
gene id: 8355:LOC121401335
uniprot id: A0A8J1MIT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:itga11.L
gene id: 8355:itga11.L
uniprot id: A0A1L8H187
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

8355:rsad2.L
gene id: 8355:rsad2.L
uniprot id: A0A8J0VCW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RSAD2 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:trarg1.S
gene id: 8355:trarg1.S
uniprot id: A0A8J0UJ76
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8355:LOC121401486
gene id: 8355:LOC121401486
uniprot id: A0A8J1MKE3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108695474
gene id: 8355:LOC108695474
uniprot id: A0A8J1L4Y5
names: Similarity
messages: Belongs to the RBR family.

8355:gal.1.S
gene id: 8355:gal.1.S
uniprot id: A0A1L8GCU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galanin family.
messages: Secreted

8355:necap2.L
gene id: 8355:necap2.L
uniprot id: Q6AX72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

8355:rundc3a.S
gene id: 8355:rundc3a.S
uniprot id: A0A1L8EL11
uniprot id: A0A8J0TYV5
uniprot id: A0A974BSU6
names: Similarity
messages: Belongs to the RUNDC3 family.

8355:taf4.S
gene id: 8355:taf4.S
uniprot id: A0A1L8ELM3
uniprot id: A0A8J0TZ75
uniprot id: A0A8J0TZ78
uniprot id: A0A974BSZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF4 family.
messages: Nucleus

8355:LOC108710552
gene id: 8355:LOC108710552
uniprot id: A0A1L8H4M7
uniprot id: A0A974HUY8
names: Subcellular Location Annotation
messages: Membrane

8355:pim3.L
gene id: 8355:pim3.L
uniprot id: A0A974DDV3
uniprot id: Q2KHQ0
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

8355:tmem220.L
gene id: 8355:tmem220.L
uniprot id: Q4V7Q8
names: Subcellular Location Annotation
messages: Membrane

8355:MGC82989
gene id: 8355:MGC82989
uniprot id: Q6GN69
names: Subcellular Location Annotation
messages: lamellipodium
messages: sarcomere

8355:LOC108712833
gene id: 8355:LOC108712833
uniprot id: A0A1L8GSI7
uniprot id: A0A974D6Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

8355:LOC108715130
gene id: 8355:LOC108715130
uniprot id: A0A1L8GCT0
uniprot id: A0A8J0V4E9
uniprot id: A0A8J0V5P5
uniprot id: A0A974HL42
names: Similarity
messages: Belongs to the spectrin family.

8355:LOC108714181
gene id: 8355:LOC108714181
uniprot id: A0A1L8GLM1
uniprot id: A0A974D5Y7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:cybrd1.S
gene id: 8355:cybrd1.S
uniprot id: A0A1L8EP67
uniprot id: A0A974H1A4
names: Subcellular Location Annotation
messages: Membrane

8355:slc25a45.S
gene id: 8355:slc25a45.S
uniprot id: A0A1L8GCY4
uniprot id: A0A974CYJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8355:LOC108703416
gene id: 8355:LOC108703416
uniprot id: A0A8J1MRR2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:smim7.S
gene id: 8355:smim7.S
uniprot id: A0A8J1LQU0
uniprot id: Q6INP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM7 family.
messages: Membrane

8355:LOC121399774
gene id: 8355:LOC121399774
uniprot id: A0A8J1M8A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC121399054
gene id: 8355:LOC121399054
uniprot id: A0A8J1LZ66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

8355:brf1.L
gene id: 8355:brf1.L
uniprot id: A0A974H8E1
uniprot id: Q63ZQ0
names: Similarity
messages: Belongs to the TFIIB family.

8355:LOC108704998
gene id: 8355:LOC108704998
uniprot id: A0A8J1M4M9
uniprot id: A0A8J1M4N2
uniprot id: A0A8J1M5Q9
uniprot id: A0A8J1M6G1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:cuzd1.2.L
gene id: 8355:cuzd1.2.L
uniprot id: A0A8J1L8U9
names: Caution
names: Similarity
messages: Belongs to the DMBT1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:ssbp3.L
gene id: 8355:ssbp3.L
uniprot id: A0A1L8GMI1
uniprot id: A0A8J1MTI9
uniprot id: A0A8J1MUE3
uniprot id: A0A974D4M0
uniprot id: A0A974D6D7
uniprot id: Q801Q3
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108703799
gene id: 8355:LOC108703799
uniprot id: A0A1L8G0S8
uniprot id: A0A974HGS3
uniprot id: P62799
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by pak2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

8355:cav1.L
gene id: 8355:cav1.L
uniprot id: Q8JHX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

8355:ptpre.L
gene id: 8355:ptpre.L
uniprot id: A0A1L8HSH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
messages: Cell membrane
messages: Membrane

8355:vamp7.L
gene id: 8355:vamp7.L
uniprot id: A0A974H7E7
uniprot id: Q6DDH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

8355:XB5953084.L
gene id: 8355:XB5953084.L
uniprot id: A0A8J0VK45
uniprot id: A0A8J0VL82
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8355:nhs.L
gene id: 8355:nhs.L
uniprot id: A0A1L8HG29
uniprot id: A0A8J0UB85
uniprot id: A0A8J0UCI2
uniprot id: A0A974DPG8
uniprot id: Q5U4N4
names: Similarity
messages: Belongs to the NHS family.

8355:mip.L
gene id: 8355:mip.L
uniprot id: Q5XGU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

8355:sfrpx.L
gene id: 8355:sfrpx.L
uniprot id: A0A1L8HJN4
uniprot id: A0A974I020
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:egr3.S
gene id: 8355:egr3.S
uniprot id: A0A1L8GRR6
uniprot id: A0A974D6H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

8355:ca9.L
gene id: 8355:ca9.L
uniprot id: A0A1L8I392
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

8355:gab2.L
gene id: 8355:gab2.L
uniprot id: A0A1L8HJE4
uniprot id: A0A974DRK5
names: Similarity
messages: Belongs to the GAB family.

8355:med16.L
gene id: 8355:med16.L
uniprot id: A0A1L8HWL9
uniprot id: A0A974DYX1
uniprot id: A0A974E0T1
uniprot id: Q566H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 16 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8355:des.1.L
gene id: 8355:des.1.L
uniprot id: Q6AZI8
names: Similarity
messages: Belongs to the intermediate filament family.

8355:kcnj4.L
gene id: 8355:kcnj4.L
uniprot id: A0A1L8GNY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

8355:tbx15.L
gene id: 8355:tbx15.L
uniprot id: A0A0U2V9A5
uniprot id: A0A974DKA0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8355:mon1b.S
gene id: 8355:mon1b.S
uniprot id: A0A1L8EZK1
uniprot id: A0A974C1U5
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

8355:nat10.L
gene id: 8355:nat10.L
uniprot id: A0A8J0V053
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Interacts with THUMPD1.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

8355:aplp1.L
gene id: 8355:aplp1.L
uniprot id: A0A8J0SZM3
uniprot id: A0A974CJR0
uniprot id: Q52KN8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:LOC108719591
gene id: 8355:LOC108719591
uniprot id: A0A8J1MTD5
names: Subcellular Location Annotation
messages: Membrane

8355:sde2.L
gene id: 8355:sde2.L
uniprot id: A0A1L8G6M9
uniprot id: A0A974CVY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDE2 family.
messages: Cytoplasm
messages: Nucleus

8355:kcnh3.L
gene id: 8355:kcnh3.L
uniprot id: A0A1L8HHS1
uniprot id: A0A974DRX4
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

8355:mchr1.2.L
gene id: 8355:mchr1.2.L
uniprot id: A0A1L8EY44
uniprot id: A0A974C089
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with NCDN.
messages: Membrane

8355:LOC121395694
gene id: 8355:LOC121395694
uniprot id: A0A8J1L8M6
uniprot id: A0A8J1LA84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8355:LOC108705137
gene id: 8355:LOC108705137
uniprot id: A0A8J0U5L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:kcnj4.S
gene id: 8355:kcnj4.S
uniprot id: A0A1L8GH52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

8355:srd5a2.L
gene id: 8355:srd5a2.L
uniprot id: A0A1L8G8B0
uniprot id: A0A974CW89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane
messages: Microsome membrane

8355:wnt8a.L
gene id: 8355:wnt8a.L
uniprot id: P28026
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Wnt family.
messages: Homooligomer; disulfide-linked, leading to inactivation. Interacts with the long chain of cer1.
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in ventral mesodermal patterning during embryogenesis. Mimics Nieuwkoop center activity. Causes dorsal mesodermal differentiation of animal cap ectoderm when coexpressed with noggin and nuclear, sequence-specific DNA-binding protein xBra. None of these molecules causes dorsal mesoderm formation when expressed alone.
messages: Mid-blastula, decline by tailbud.
messages: Palmitoleoylation is required for efficient binding to frizzled receptors (PubMed:22653731). Depalmitoleoylation leads to Wnt signaling pathway inhibition (By similarity).
messages: Proteolytic processing by tiki1 and tiki2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of wnt8.
messages: extracellular matrix

8355:agxt.S
gene id: 8355:agxt.S
uniprot id: A0A8J0VGD5
uniprot id: A0A8J1KUB6
uniprot id: A0A8J1KXC5
names: Similarity
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

8355:eif2b1.L
gene id: 8355:eif2b1.L
uniprot id: Q6NUG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.
messages: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
messages: Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

8355:LOC108710294
gene id: 8355:LOC108710294
uniprot id: A0A8J0US18
uniprot id: A0A8J1MLM2
uniprot id: A0A8J1MMJ8
uniprot id: A0A8J1MML9
uniprot id: A0A8J1MNP8
uniprot id: A0A8J1MNQ3
names: Subcellular Location Annotation
messages: Membrane

8355:LOC121396929
gene id: 8355:LOC121396929
uniprot id: A0A8J1LG78
names: Similarity
messages: Belongs to the SUA5 family.

8355:ifrd1.S
gene id: 8355:ifrd1.S
uniprot id: A0A974HR21
uniprot id: Q6PF29
names: Similarity
messages: Belongs to the IFRD family.

8355:zar1l.S
gene id: 8355:zar1l.S
uniprot id: A0A1L8HBI7
uniprot id: A0A974HWX6
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ZAR1 family.
messages: Component of a cytoplasmic ribonucleoprotein complex together with eif4enif1/4E-T and cpeb1.
messages: Cytoplasmic ribonucleoprotein granule
messages: Disordered regions undergo liquid-liquid phase separation (LLPS) for the formation of membraneless compartments that store maternal mRNAs in oocytes.
messages: Expressed in oocytes.
messages: Expressed in stage VI oocytes; its levels clearly decrease after progesterone addition.
messages: The 3CxxC-type mediates binding to the 3'-UTR of mRNAs.
messages: mRNA-binding protein required for maternal mRNA storage, translation and degradation during oocyte maturation (PubMed:36278895). Controls timing of meiosis during oogenesis (PubMed:36278895). Probably promotes formation of some phase-separated membraneless compartment that stores maternal mRNAs in oocytes: acts by undergoing liquid-liquid phase separation upon binding to maternal mRNAs (By similarity). Binds to the 3'-UTR of maternal mRNAs, inhibiting their translation (PubMed:36278895).

8355:LOC108707069
gene id: 8355:LOC108707069
uniprot id: A0A8J0U1R9
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.

8355:LOC108697012
gene id: 8355:LOC108697012
uniprot id: A0A1L8FMB3
uniprot id: A0A974HCS3
names: Similarity
messages: Belongs to the MS4A family.

8355:spns1.S
gene id: 8355:spns1.S
uniprot id: A0A8J0U3K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8355:has2.S
gene id: 8355:has2.S
uniprot id: O57427
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NodC/HAS family.
messages: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation (By similarity). This is one of three isoenzymes responsible for cellular hyaluronan synthesis and it is particularly responsible for the synthesis of high molecular mass hyaluronan (By similarity).
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer; dimerization promotes enzymatic activity.
messages: Lysosome
messages: Vesicle

8355:LOC108700456
gene id: 8355:LOC108700456
uniprot id: A0A1L8EZJ0
names: Similarity
messages: Belongs to the DNase I family.

8355:lipt1.L
gene id: 8355:lipt1.L
uniprot id: A0A1L8HGT8
uniprot id: A0A974DQ02
uniprot id: Q66KR7
names: Similarity
messages: Belongs to the LplA family.

8355:slc39a3.S
gene id: 8355:slc39a3.S
uniprot id: A0A1L8HN89
uniprot id: A0A974DV21
names: Subcellular Location Annotation
messages: Membrane

8355:ftmt.S
gene id: 8355:ftmt.S
uniprot id: A0A974HKW7
uniprot id: Q7ZXM8
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

8355:tmem106b.L
gene id: 8355:tmem106b.L
uniprot id: A0A974HFJ1
uniprot id: Q6GQ10
names: Similarity
messages: Belongs to the TMEM106 family.

8355:LOC108714471
gene id: 8355:LOC108714471
uniprot id: A0A1L8GNG4
uniprot id: A0A8J1MXI5
uniprot id: A0A8J1MYP1
uniprot id: A0A8J1MZ84
uniprot id: A0A8J1N001
uniprot id: A0A974D666
names: Similarity
messages: Belongs to the Luc7 family.

8355:tmed5.S
gene id: 8355:tmed5.S
uniprot id: A0A1L8GG75
uniprot id: A0A974D1W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

8355:nsmce4a.S
gene id: 8355:nsmce4a.S
uniprot id: A0A1L8FE93
uniprot id: A0A8J0TDM8
uniprot id: A0A974CB44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE4 family.
messages: Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
messages: Component of the SMC5-SMC6 complex.
messages: Nucleus
messages: telomere

8355:LOC108696727
gene id: 8355:LOC108696727
uniprot id: A0A974CGN9
uniprot id: V5ZDY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

8355:tmem9b.S
gene id: 8355:tmem9b.S
uniprot id: A0A1L8GE26
uniprot id: A0A974HLF1
names: Similarity
messages: Belongs to the TMEM9 family.

8355:rgs12.L
gene id: 8355:rgs12.L
uniprot id: A0A8J0TH30
names: Subcellular Location Annotation
messages: Cytoplasm

8355:raly.L
gene id: 8355:raly.L
uniprot id: A0A1L8EU32
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

8355:gdpd2.L
gene id: 8355:gdpd2.L
uniprot id: A0A1L8F715
uniprot id: A0A974C602
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

8355:lsm7.L
gene id: 8355:lsm7.L
uniprot id: A0A974DYM5
uniprot id: Q6DKD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

8355:fuca1.S
gene id: 8355:fuca1.S
uniprot id: A0A310TRB4
uniprot id: A0A974BRR9
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

8355:vrk1.L
gene id: 8355:vrk1.L
uniprot id: A0A1L8F9N0
uniprot id: A0A974C853
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC121403111
gene id: 8355:LOC121403111
uniprot id: A0A8J1MXT9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natural cytotoxicity receptor (NCR) family.
messages: Cell membrane
messages: Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6.
messages: Membrane

8355:LOC108698283
gene id: 8355:LOC108698283
uniprot id: A0A8J0TGD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8355:LOC108696199
gene id: 8355:LOC108696199
uniprot id: A0A1L8FJP3
uniprot id: A0A8J0T9T4
uniprot id: A0A8J0TA15
uniprot id: A0A974HBF8
names: Subcellular Location Annotation
messages: Membrane

8355:akap12.S
gene id: 8355:akap12.S
uniprot id: A0A8J1KSP7
uniprot id: A0A8J1KSR0
names: Subcellular Location Annotation
messages: Membrane

8355:cpsf7.S
gene id: 8355:cpsf7.S
uniprot id: A0A8J0V4X1
uniprot id: A0A974CXT7
uniprot id: Q0IH99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Nucleus

8355:XB5738351.S
gene id: 8355:XB5738351.S
uniprot id: A0A1L8GST1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

8355:pcbd1.L
gene id: 8355:pcbd1.L
uniprot id: A0A8J1L9Z8
uniprot id: A0A8J1LEG7
uniprot id: Q63ZS4
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

8355:prcp.L
gene id: 8355:prcp.L
uniprot id: A0A1L8HJS7
uniprot id: A0A974DQY0
names: Similarity
messages: Belongs to the peptidase S28 family.

8355:LOC108708763
gene id: 8355:LOC108708763
uniprot id: A0A8J1M6C4
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108698633
gene id: 8355:LOC108698633
uniprot id: A0A8J0TK73
names: Subcellular Location Annotation
messages: Nucleus

8355:slc17a9.L
gene id: 8355:slc17a9.L
uniprot id: A0A1L8ET56
uniprot id: A0A974BXT9
names: Subcellular Location Annotation
messages: Membrane

8355:ap1b1.S
gene id: 8355:ap1b1.S
uniprot id: A1L2H5
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

8355:cbr4.L
gene id: 8355:cbr4.L
uniprot id: Q6NUE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Homotetramer (in vitro). Heterotetramer with HSD17B8; contains two molecules each of HSD17B8 and CBR4.
messages: Mitochondrion matrix
messages: The heterotetramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD. The homotetramer has NADPH-dependent quinone reductase activity. Both homotetramer and the heterotetramer have broad in vitro substrate specificity and can reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones.

8355:tfap2b.S
gene id: 8355:tfap2b.S
uniprot id: A0A1L8G5L2
uniprot id: A0A8J0VDS7
uniprot id: A0A974HIG0
names: Similarity
messages: Belongs to the AP-2 family.

8355:LOC108713133
gene id: 8355:LOC108713133
uniprot id: A0A1L8GUC0
uniprot id: A0A8J1MT44
uniprot id: A0A974HRL7
names: Similarity
messages: Belongs to the TAFA family.

8355:mtnr1b.L
gene id: 8355:mtnr1b.L
uniprot id: A0A8J1M863
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:pdp2.L
gene id: 8355:pdp2.L
uniprot id: A0A1L8GL17
uniprot id: A0A974HNF2
names: Similarity
messages: Belongs to the PP2C family.

8355:rhbdl1.L
gene id: 8355:rhbdl1.L
uniprot id: A0A1L8EYT2
uniprot id: A0A974C179
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Membrane

8355:LOC108698255
gene id: 8355:LOC108698255
uniprot id: A0A1L8F6J5
uniprot id: A0A974C6B3
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC108714534
gene id: 8355:LOC108714534
uniprot id: A0A8J0UY08
uniprot id: A0A8J0V7E1
names: Similarity
messages: Belongs to the carnosine N-methyltransferase family.

8355:alg3.S
gene id: 8355:alg3.S
uniprot id: A0A8J1KR54
uniprot id: A0A974HHR3
uniprot id: A0A974HHV3
uniprot id: A9JS09
uniprot id: B7ZS40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
messages: Belongs to the glycosyltransferase 58 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:ttc21b.L
gene id: 8355:ttc21b.L
uniprot id: A0A8J1LRR7
names: Similarity
messages: Belongs to the TTC21 family.

8355:ptgs2.L
gene id: 8355:ptgs2.L
uniprot id: A0A1L8GNN4
uniprot id: A0A974D7D6
names: Caution
names: Similarity
messages: Belongs to the prostaglandin G/H synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108698311
gene id: 8355:LOC108698311
uniprot id: A0A1L8F6W9
uniprot id: A0A8J0TAB9
uniprot id: A0A8J0TI66
uniprot id: A0A8J0TIZ7
uniprot id: A0A974C5Y3
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8355:mc3r.S
gene id: 8355:mc3r.S
uniprot id: A0A1L8ELH4
uniprot id: A0A974H0C5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.

8355:bco2.L
gene id: 8355:bco2.L
uniprot id: Q6DCS3
names: Cofactor
names: Similarity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.

8355:LOC108705134
gene id: 8355:LOC108705134
uniprot id: A0A8J0U922
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:eif3b.S
gene id: 8355:eif3b.S
uniprot id: A0A1L8EQD3
uniprot id: A0A974H1Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit B family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

8355:tnrc6c.S
gene id: 8355:tnrc6c.S
uniprot id: A0A8J1LZ55
uniprot id: A0A8J1LZ60
uniprot id: A0A8J1LZC8
uniprot id: A0A8J1LZD3
uniprot id: A0A8J1M0F4
uniprot id: A0A8J1M1C4
names: Similarity
messages: Belongs to the GW182 family.

8355:LOC108704501
gene id: 8355:LOC108704501
uniprot id: A0A8J0U5G7
uniprot id: A0A8J1LHP1
names: Subcellular Location Annotation
messages: Nucleus

8355:cmpk1.L
gene id: 8355:cmpk1.L
uniprot id: A0A8J0V2H3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

8355:zadh2.S
gene id: 8355:zadh2.S
uniprot id: Q498I7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

8355:mapre1.L
gene id: 8355:mapre1.L
uniprot id: A0A974BWX4
uniprot id: Q8UW78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

8355:cyfip1.L
gene id: 8355:cyfip1.L
uniprot id: A0A1L8HGY3
uniprot id: A0A8J0UFV3
uniprot id: A0A974DRC7
names: Similarity
messages: Belongs to the CYFIP family.

8355:ednra.L
gene id: 8355:ednra.L
uniprot id: A0A974DX06
uniprot id: Q7ZXQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with HDAC7 and KAT5.
messages: Membrane
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

8355:cldn2.L
gene id: 8355:cldn2.L
uniprot id: A0A1L8F6M6
uniprot id: A0A974C6C3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8355:sdc3.S
gene id: 8355:sdc3.S
uniprot id: A0A1L8H7U3
uniprot id: A0A974DJV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

8355:dnai4.S
gene id: 8355:dnai4.S
uniprot id: Q6GPB9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Dynein axonemal particle
messages: Part of the multisubunit axonemal dynein complex formed at least of two heavy chains and a number of intermediate and light chains. Associated with axonemal dynein subunits such as, DNAH2, DNAI3, and DYNLT1.
messages: Plays a critical role in the assembly of axonemal dynein complex, thereby playing a role in ciliary motility.
messages: cilium axoneme
messages: flagellum axoneme

8355:LOC108703502
gene id: 8355:LOC108703502
uniprot id: A0A8J1MSQ9
names: Subcellular Location Annotation
messages: Secreted

8355:supt4h1.S
gene id: 8355:supt4h1.S
uniprot id: A0A974DGW1
uniprot id: Q5HZ97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT4 family.
messages: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.
messages: Interacts with SUPT5H to form the DSIF complex. DSIF interacts with RNA polymerase II and with the positive transcription elongation factor b complex (P-TEFb complex), which is composed of CDK9 and cyclin-T (By similarity).
messages: May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. Probably enhances transcriptional pausing at sites proximal to the promoter, which may in turn facilitate the assembly of an elongation competent RNA polymerase II complex (By similarity).
messages: Nucleus

8355:slbp.S
gene id: 8355:slbp.S
uniprot id: A0A974DTB4
uniprot id: Q6GNP3
names: Similarity
messages: Belongs to the SLBP family.

8355:ventx1.2.S
gene id: 8355:ventx1.2.S
uniprot id: B7ZQJ4
uniprot id: Q91926
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: By bmp4. Suppressed by gsc, acting in a negative cross-regulatory loop.
messages: Expressed in the ventral marginal zone of gastrulae. At stage 11.5, also expressed in the ventral region of the animal cap (ectoderm). At the end of gastrulation, predominantly localized to the ventral and lateral regions of the closing slit blastopore. At early tail bud stage, expression is maintained only in the forming proctodeum.
messages: Expression begins in the late blastula, peaks at state 11 (early gastrula) and decreases thereafter.
messages: Nucleus
messages: The N-terminal region is required for repressor function.
messages: Transcriptional repressor. Cooperates with vent2 in a ventral signaling pathway downstream of bmp4, which antagonizes the Spemann organizer and dorsal mesoderm formation, and leads to ventral mesoderm formation. Acts downstream of bmp4 to repress transcription of foxa4-B/XFD-1'. Binds to DNA with preference for the target sequence 5'-CTATT[T/C]G-3'. Also binds 5'-TGCATTTTG-3' at a lower frequency, and occasionally 5'-TTGATC-3'. Binds to the homeobox 2 (HBX2) repressor element in the promoter of the myf5 gene and represses myf5 transcription in the ventral domain.

8355:emc2.S
gene id: 8355:emc2.S
uniprot id: A0A974HEI2
uniprot id: Q8AVU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.

8355:capn13.S
gene id: 8355:capn13.S
uniprot id: A0A1L8G0X4
uniprot id: A0A974CPX3
names: Similarity
messages: Belongs to the peptidase C2 family.

8355:gba3.L
gene id: 8355:gba3.L
uniprot id: A0A974I2E1
uniprot id: Q66J37
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

8355:pdcd5.S
gene id: 8355:pdcd5.S
uniprot id: A0A974CYM4
uniprot id: Q5U5C7
names: Similarity
messages: Belongs to the PDCD5 family.

8355:LOC108713475
gene id: 8355:LOC108713475
uniprot id: A0A8J1MWR1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108697161
gene id: 8355:LOC108697161
uniprot id: A0A1L8FE32
uniprot id: A0A974CB27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108698967
gene id: 8355:LOC108698967
uniprot id: A0A8J1LHD3
uniprot id: A0A8J1LIS3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC121402243
gene id: 8355:LOC121402243
uniprot id: A0A8J1MTI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:rell1.S
gene id: 8355:rell1.S
uniprot id: A0A1L8HKZ4
uniprot id: A0A1L8HL14
uniprot id: A0A974DRS1
uniprot id: A0A974DRU3
uniprot id: Q7T0N2
names: Similarity
messages: Belongs to the RELT family.

8355:atoh7.S
gene id: 8355:atoh7.S
uniprot id: A0A974H9S8
uniprot id: B7ZQX7
uniprot id: O13125
names: Developmental Stage
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: First detected at stage 17 as 2 symmetric patches in the region of the presumptive olfactory placode. Expressed in the pineal at stage 23, and in the eye starting from stage 24. By stage 27, strongly expressed in retina, olfactory placodes and pineal. At stage 32, expression strongly decreases in olfactory placodes and pineal but is maintained in the neuroretina. At stage 41, expression is restricted to the ciliary marginal zone of the retina.
messages: Inhibited by Notch and ESR1.
messages: Nucleus
messages: Perikaryon
messages: Transcription factor that binds to DNA at the consensus sequence 5'-CAG[GC]TG-3' (By similarity). Positively regulates the determination of retinal ganglion cell fate and formation of the optic nerve and retino-hypothalamic tract (PubMed:9390513). Required for retinal circadian rhythm photoentrainment (By similarity). Plays a role in brainstem auditory signaling and binaural processing (By similarity). Regulates the differentiation of olfactory receptor neurons (PubMed:12454929). During retinal neurogenesis, activates the transcription of several genes such as brn3d, coe3, cbfa2t2, glis2, elrC and xgadd45-gamma (PubMed:11401395, PubMed:16112102).
messages: axon

8355:LOC108701971
gene id: 8355:LOC108701971
uniprot id: A0A1L8EZB9
uniprot id: A0A974C177
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:celf1.L
gene id: 8355:celf1.L
uniprot id: O57406
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Expressed in egg and embryo (at protein level).
messages: Nucleus
messages: Oligomer. Oligomerization is required for RNA-binding and EDEN-dependent deadenylation.
messages: Phosphorylated during oocyte maturation and dephosphorylated following egg activation. Dephosphorylation is calcium dependent and correlates with the increase in the activity of EDEN-dependent deadenylation.
messages: RNA-binding protein implicated in the regulation of several post-transcriptional events. May be involved in pre-mRNA alternative splicing, mRNA translation activation and stability (By similarity). Mediates the rapid and sequence-specific cytoplasmic deadenylation of EDEN-containing maternal mRNAs following fertilization. Binds to AU-rich sequences (AREs) of jun mRNA. Binds to the embryonic deadenylation element (EDEN) motif localized in the 3'-UTR of maternal mRNAs. Binds to RNA containing several repeats of the consensus sequence 5'-UGU-3'. EDEN-dependent deadenylation is enhanced by the presence of an additional cis element composed of three AUU repeats.
messages: The 2 N-terminal RRMs and a part of the linker region (between RRM2 and RRM3) are necessary for binding to EDEN of mos mRNA.

8355:LOC108703562
gene id: 8355:LOC108703562
uniprot id: A0A8J0TUV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:eif3f.S
gene id: 8355:eif3f.S
uniprot id: A0A1L8F4T2
uniprot id: A0A974H6H7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit F family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

8355:hnmt.L
gene id: 8355:hnmt.L
uniprot id: Q5U4V2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.
messages: Cytoplasm
messages: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
messages: Monomer.

8355:LOC108716242
gene id: 8355:LOC108716242
uniprot id: A0A1L8GBD4
uniprot id: A0A974HKI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

8355:borcs8.S
gene id: 8355:borcs8.S
uniprot id: A0A8J0TV28
uniprot id: A0A8J0U2B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS8 family.
messages: Lysosome membrane
messages: Membrane

8355:abl1.S
gene id: 8355:abl1.S
uniprot id: A0A1L8F1E7
uniprot id: A0A8J0TMR9
uniprot id: A0A8J0TNY6
uniprot id: A0A8J0TQX8
uniprot id: A0A974C2W2
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

8355:LOC108695718
gene id: 8355:LOC108695718
uniprot id: A0A8J0T9Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:myo9b.L
gene id: 8355:myo9b.L
uniprot id: A0A1L8HXG8
uniprot id: A0A8J1KNN6
uniprot id: A0A8J1KNP8
uniprot id: A0A8J1KQC2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8355:pim3.S
gene id: 8355:pim3.S
uniprot id: Q91822
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Cytoplasm
messages: Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis and promote cell survival and protein translation.
messages: Was originally called Pim-1 but seems to represent the protein pim3.

8355:lck.L
gene id: 8355:lck.L
uniprot id: A1L2U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Membrane
messages: cytosol

8355:elapor2.L
gene id: 8355:elapor2.L
uniprot id: Q6DDW2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Expressed in the animal half of the embryo during gastrulation, becoming restricted to the ventral ectoderm at stage 12.5. At the neurula stage, expressed in the anterior ectoderm surrounding the neural plate, and weakly in the epidermis. Expression is especially high in the presumptive hatching gland and cement gland regions. Surprisingly, by the tailbud stage (stage 22), expression is limited to the hatching gland and is not seen in the cement gland. Conversely, in tadpoles expressed broadly in the head, heart and fin. Expression in the head is seen in the primary mouth and in the brain, eyes, otic vesicles and olfactory pits.
messages: Expression is down-regulated by ras.
messages: First expressed at stage 9, after the mid-blastula transition (MBT). Expression is highest at stage 10.5 and remains constant until the tadpole stage (PubMed:17475571). First detected at stage 10.5, expression increases gradually until the tadpole stage (at protein level) (PubMed:21177533). Highly expressed in the epidermal ectoderm at the neurula stage (PubMed:21177533).
messages: Functions as a regulator of the BMP signaling pathway and is involved in epidermal differentiation.
messages: Morpholino knockdown induces severe developmental defects including dorsal open phenotype and the reduction of head and tail structures at the tailbud stage.

8355:LOC121398103
gene id: 8355:LOC121398103
uniprot id: A0A8J1LU79
names: Subcellular Location Annotation
messages: Nucleus

8355:il17rc.S
gene id: 8355:il17rc.S
uniprot id: A0A8J1KK46
uniprot id: A0A8J1KN69
names: Subcellular Location Annotation
messages: Membrane

8355:aprt.L
gene id: 8355:aprt.L
uniprot id: A0A8J0TXN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm

8355:palmd.S
gene id: 8355:palmd.S
uniprot id: A0A1L8GG73
uniprot id: A0A974D1X0
names: Similarity
messages: Belongs to the paralemmin family.

8355:LOC108702042
gene id: 8355:LOC108702042
uniprot id: A0A1L8ET48
uniprot id: A0A974H2J9
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

8355:LOC121400435
gene id: 8355:LOC121400435
uniprot id: A0A8J1MDN4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:gng2.L
gene id: 8355:gng2.L
uniprot id: Q66KU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8355:kcnt2.L
gene id: 8355:kcnt2.L
uniprot id: A0A8J1MXG4
uniprot id: A0A8J1MXP9
uniprot id: A0A8J1MZ63
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108719245
gene id: 8355:LOC108719245
uniprot id: A0A1L8FZ06
uniprot id: A0A974CPX0
names: Similarity
messages: Belongs to the PPDPF family.

8355:LOC108703445
gene id: 8355:LOC108703445
uniprot id: A0A8J0TUI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:cnn1.L
gene id: 8355:cnn1.L
uniprot id: A0A974GZN6
uniprot id: Q6IR60
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

8355:ubl3.L
gene id: 8355:ubl3.L
uniprot id: A0A974HWT5
uniprot id: Q6GNJ9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:adgrl2.S
gene id: 8355:adgrl2.S
uniprot id: A0A1L8GFI9
uniprot id: A0A8J0V5U5
uniprot id: A0A8J0V6L9
uniprot id: A0A8J0VB76
uniprot id: A0A8J1KIP6
uniprot id: A0A8J1KIQ1
uniprot id: A0A8J1KIR3
uniprot id: A0A8J1KIR5
uniprot id: A0A8J1KIR8
uniprot id: A0A8J1KIS0
uniprot id: A0A8J1KIS4
uniprot id: A0A8J1KIS6
uniprot id: A0A8J1KIS8
uniprot id: A0A8J1KIT0
uniprot id: A0A8J1KIT2
uniprot id: A0A8J1KIT5
uniprot id: A0A8J1KIT8
uniprot id: A0A8J1KIU1
uniprot id: A0A8J1KIV1
uniprot id: A0A8J1KKF9
uniprot id: A0A8J1KKG2
uniprot id: A0A8J1KKG7
uniprot id: A0A8J1KKH2
uniprot id: A0A8J1KKH7
uniprot id: A0A8J1KKI3
uniprot id: A0A8J1KKI8
uniprot id: A0A8J1KLV4
uniprot id: A0A8J1KLV9
uniprot id: A0A8J1KLW5
uniprot id: A0A8J1KLX1
uniprot id: A0A8J1KLY4
uniprot id: A0A8J1KLZ0
uniprot id: A0A974D1H6
names: Subcellular Location Annotation
messages: Membrane

8355:psmb6.L
gene id: 8355:psmb6.L
uniprot id: A0A974DHN3
uniprot id: Q3KPV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

8355:cog3.S
gene id: 8355:cog3.S
uniprot id: A0A1L8H9H2
uniprot id: A0A8J0ULH2
uniprot id: A0A974DKC8
names: Function
names: Similarity
messages: Belongs to the COG3 family.
messages: Involved in ER-Golgi transport.

8355:LOC121393142
gene id: 8355:LOC121393142
uniprot id: A0A8J1LX58
names: Subcellular Location Annotation
messages: Secreted

8355:ykt6.S
gene id: 8355:ykt6.S
uniprot id: A0A974D6P5
uniprot id: Q6DDU7
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Cytoplasmic vesicle membrane
messages: Farnesylation is required for Golgi targeting.
messages: Golgi apparatus membrane
messages: Maternally inherited. Detected in oocytes and eggs. Expression declines during early development and is not detected in neurula, tailbud and tadpole embryos.
messages: Membrane
messages: Palmitoylated; catalyzes its own palmitoylation. Palmitoylation is required for Golgi targeting.
messages: The longin domain regulates palmitoylation and membrane targeting.
messages: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.
messages: cytosol

8355:krt57.L
gene id: 8355:krt57.L
uniprot id: P02537
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the intermediate filament family.
messages: Heterotetramer of two type I and two type II keratins.
messages: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

8355:tnfrsf19.S
gene id: 8355:tnfrsf19.S
uniprot id: A0A1L8HAQ6
uniprot id: A0A974DLY6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:tmed5.L
gene id: 8355:tmed5.L
uniprot id: Q0IH74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

8355:pik3r2.S
gene id: 8355:pik3r2.S
uniprot id: A0A1L8HNI8
uniprot id: A0A8J0U9D3
uniprot id: A0A974I164
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

8355:tpp1.L
gene id: 8355:tpp1.L
uniprot id: A0A974HZJ9
uniprot id: Q6NTQ6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:diaph3.L
gene id: 8355:diaph3.L
uniprot id: A0A8J0U842
uniprot id: A0A8J0UEW7
uniprot id: A0A8J0UG70
uniprot id: A0A8J0UGE8
uniprot id: A0A8J0UIY2
names: Similarity
messages: Belongs to the formin homology family. Diaphanous subfamily.

8355:pdpr.S
gene id: 8355:pdpr.S
uniprot id: A0A1L8GF20
uniprot id: A0A974CZW1
names: Similarity
messages: Belongs to the GcvT family.

8355:abcc10.L
gene id: 8355:abcc10.L
uniprot id: A0A1L8G709
uniprot id: A0A974CVJ2
names: Subcellular Location Annotation
messages: Membrane

8355:tmprss2.13.L
gene id: 8355:tmprss2.13.L
uniprot id: A0A1L8HCC0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:rad50.L
gene id: 8355:rad50.L
uniprot id: A0A1L8GXM0
uniprot id: A0A974DCN0
uniprot id: C4N9Q9
names: Similarity
messages: Belongs to the SMC family. RAD50 subfamily.

8355:tcf3.L
gene id: 8355:tcf3.L
uniprot id: Q01978
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer. Heterodimer; efficient DNA binding requires dimerization with another bHLH protein (By similarity). Interacts with tgfb1i1 (PubMed:16291758).
messages: Isoform E12 and isoform E47 are present at all the stages of development and in all regions of the embryo.
messages: Nucleus
messages: Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition. Heterodimers between tcf3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Together with tcf15, required for the mesenchymal to epithelial transition. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'.

8355:elk3.S
gene id: 8355:elk3.S
uniprot id: A0A1L8GUU6
uniprot id: A0A8J0UWU8
uniprot id: A0A974HRU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8355:tubb.L
gene id: 8355:tubb.L
uniprot id: A0A974H7Y3
uniprot id: Q91575
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity).
messages: Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. The precise function of polyglycylation is still unclear.
messages: The MREI motif is common among all beta-tubulin isoforms and may be critical for tubulin autoregulation.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

8355:bcat2.L
gene id: 8355:bcat2.L
uniprot id: A9JS68
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

8355:homez.S
gene id: 8355:homez.S
uniprot id: A0A1L8HPH7
uniprot id: A0A974DTT1
names: Subcellular Location Annotation
messages: Nucleus

8355:stk33.L
gene id: 8355:stk33.L
uniprot id: A0A1L8GIB0
uniprot id: A0A8J0UU94
uniprot id: A0A974D260
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:ndufv2.L
gene id: 8355:ndufv2.L
uniprot id: A0A1L8FYH9
uniprot id: A0A974CP11
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.

8355:ppfibp2.L
gene id: 8355:ppfibp2.L
uniprot id: Q6DCK5
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

8355:mst1.S
gene id: 8355:mst1.S
uniprot id: A0A1L8GHB0
uniprot id: A0A8J1MZ45
uniprot id: A0A8J1N1S7
names: Caution
names: Similarity
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:tnk2.L
gene id: 8355:tnk2.L
uniprot id: A0A8J1KPE1
uniprot id: A0A8J1KPE4
uniprot id: A0A8J1KPF0
uniprot id: A0A8J1KR10
uniprot id: A0A8J1KR15
uniprot id: A0A8J1KSJ0
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

8355:fscn1.S
gene id: 8355:fscn1.S
uniprot id: A0A1L8EQ20
uniprot id: A0A974BVV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

8355:gns.S
gene id: 8355:gns.S
uniprot id: A0A8J0UU68
uniprot id: Q8AVH8
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Lysosome
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

8355:sh2b2.L
gene id: 8355:sh2b2.L
uniprot id: A0A1L8HDT1
uniprot id: A0A8J0UGX4
uniprot id: A0A974DNI1
names: Similarity
messages: Belongs to the SH2B adapter family.

8355:wfikkn2.S
gene id: 8355:wfikkn2.S
uniprot id: A0A974BUB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WFIKKN family.
messages: Secreted

8355:smurf2.S
gene id: 8355:smurf2.S
uniprot id: Q2TAS2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: Membrane raft
messages: Nucleus

8355:selenbp1.S
gene id: 8355:selenbp1.S
uniprot id: A0A974C4Y1
uniprot id: Q6DCH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selenium-binding protein family.
messages: Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria (By similarity). Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity).
messages: Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.
messages: Membrane
messages: Nucleus
messages: cytosol

8355:dmrta1.L
gene id: 8355:dmrta1.L
uniprot id: A0A1L8HYJ8
uniprot id: A0A974E1K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

8355:LOC108705655
gene id: 8355:LOC108705655
uniprot id: A0A310U6E4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the esterase D family.
messages: Cytoplasmic vesicle
messages: Serine hydrolase involved in the detoxification of formaldehyde.

8355:LOC121399270
gene id: 8355:LOC121399270
uniprot id: A0A1L8HKU5
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:axl.S
gene id: 8355:axl.S
uniprot id: A0A1L8F3Z0
uniprot id: A0A974C5F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cell membrane
messages: Membrane

8355:LOC108697162
gene id: 8355:LOC108697162
uniprot id: A0A1L8FE05
uniprot id: A0A974CB00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:ntmt1.S
gene id: 8355:ntmt1.S
uniprot id: A0A8J0TMT5
uniprot id: A0A974H5L4
uniprot id: Q4KLE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. NTM1 family.
messages: Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on target proteins.
messages: Nucleus

8355:LOC121397313
gene id: 8355:LOC121397313
uniprot id: A0A8J1LK24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:vill.S
gene id: 8355:vill.S
uniprot id: A0A974CI64
uniprot id: Q7ZX68
names: Similarity
messages: Belongs to the villin/gelsolin family.

8355:ntsr1.S
gene id: 8355:ntsr1.S
uniprot id: A0A1L8G5A8
uniprot id: A0A974CSW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108704633
gene id: 8355:LOC108704633
uniprot id: A0A8J0TXB8
uniprot id: A0A8J0U5T2
uniprot id: A0A8J1KZJ3
uniprot id: A0A8J1KZK5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:prph.S
gene id: 8355:prph.S
uniprot id: A0A8J0UGF8
uniprot id: A0A8J0UHS7
uniprot id: A0A8J0UKL5
uniprot id: A0A974HWS1
uniprot id: Q7T0V7
names: Similarity
messages: Belongs to the intermediate filament family.

8355:ugt3a2.L
gene id: 8355:ugt3a2.L
uniprot id: Q63ZR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane
messages: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).

8355:tapt1.S
gene id: 8355:tapt1.S
uniprot id: Q5EAY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Membrane
messages: Plays a role in primary cilia formation. Involved in cartilage and bone development. May play a role in the differentiation of cranial neural crest cells. May act as a downstream effector of hoxc8 during development.
messages: centrosome
messages: cilium basal body

8355:tbp.S
gene id: 8355:tbp.S
uniprot id: A0A974CRE3
uniprot id: Q5I004
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

8355:LOC108701955
gene id: 8355:LOC108701955
uniprot id: A0A8J0TWR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:prxl2a.L
gene id: 8355:prxl2a.L
uniprot id: Q641F0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
messages: Cytoplasm
messages: Involved in redox regulation of the cell. Acts as an antioxidant (By similarity).
messages: The active site cysteines correspond to the redox-active cysteines of peroxiredoxins.

8355:LOC121399294
gene id: 8355:LOC121399294
uniprot id: A0A8J1M1A5
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:ube2d3.L
gene id: 8355:ube2d3.L
uniprot id: A0A8J1M2S1
uniprot id: A0A8J1M3J5
uniprot id: A0A974I3E2
uniprot id: P62840
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53.
messages: Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex.

8355:tmem59.L
gene id: 8355:tmem59.L
uniprot id: A0A8J0UZN3
uniprot id: Q5XGQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:LOC108715345
gene id: 8355:LOC108715345
uniprot id: A0A1L8GE62
uniprot id: A0A8J0VAJ9
uniprot id: A0A8J1KI54
uniprot id: A0A8J1KI68
uniprot id: A0A974HL83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

8355:tspan14.S
gene id: 8355:tspan14.S
uniprot id: A0A8J0TUC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8355:tap2.L
gene id: 8355:tap2.L
uniprot id: A0A8J1LEH9
uniprot id: A0A974H7K3
uniprot id: Q6XXY8
names: Subcellular Location Annotation
messages: Membrane

8355:gmpr.L
gene id: 8355:gmpr.L
uniprot id: A0A1L8FY48
uniprot id: A0A974CN24
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

8355:vapb.S
gene id: 8355:vapb.S
uniprot id: Q5U511
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:LOC108707765
gene id: 8355:LOC108707765
uniprot id: A0A8J0UD57
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

8355:amdhd2.L
gene id: 8355:amdhd2.L
uniprot id: A0A1L8EYA2
uniprot id: A0A8J0TYV1
uniprot id: A0A974H4M8
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

8355:nif.S
gene id: 8355:nif.S
uniprot id: A0A974HQL2
uniprot id: Q6DDQ8
names: Similarity
messages: Belongs to the intermediate filament family.

8355:mmp24.S
gene id: 8355:mmp24.S
uniprot id: A0A1L8EMN6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

8355:LOC108710419
gene id: 8355:LOC108710419
uniprot id: A0A8J0UGK6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:dock7.S
gene id: 8355:dock7.S
uniprot id: A0A8J1KIY4
uniprot id: A0A8J1KIZ1
uniprot id: A0A8J1KIZ5
uniprot id: A0A8J1KJ00
uniprot id: A0A8J1KJ03
uniprot id: A0A8J1KJ09
uniprot id: A0A8J1KJ11
uniprot id: A0A8J1KJ15
uniprot id: A0A8J1KJ20
uniprot id: A0A8J1KKP3
uniprot id: A0A8J1KKQ0
uniprot id: A0A8J1KKQ5
uniprot id: A0A8J1KKQ9
uniprot id: A0A8J1KM45
uniprot id: A0A8J1KM50
uniprot id: A0A8J1KM57
uniprot id: A0A8J1KM62
names: Similarity
messages: Belongs to the DOCK family.

8355:flad1.L
gene id: 8355:flad1.L
uniprot id: A0A8J0T8N9
uniprot id: A0A8J1LEH5
uniprot id: Q6ING7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.
messages: In the N-terminal section; belongs to the MoaB/Mog family.
messages: The molybdenum cofactor biosynthesis protein-like region may not be functional.

8355:cited2.L
gene id: 8355:cited2.L
uniprot id: A0A974HJL6
uniprot id: Q5XGW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CITED family.
messages: Nucleus
messages: Transcriptional coactivator or corepressor of the p300/CBP-mediated transcription complex. May be involved in sex determination, early gonad development, left-right patterning during embryogenesis and differentiation of the adrenal cortex (By similarity).

8355:pdcd6ip.L
gene id: 8355:pdcd6ip.L
uniprot id: Q9W6C5
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Melanosome
messages: Midbody ring
messages: Multifunctional protein that may be involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles that are generated by invagination and scission from the limiting membrane of the endosome (By similarity). Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP. Ensures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity).
messages: Phosphorylated on tyrosine residues.
messages: centrosome
messages: cytosol
messages: extracellular exosome
messages: tight junction

8355:dynlt1.L
gene id: 8355:dynlt1.L
uniprot id: A0A1L8G8P0
uniprot id: A0A974CVJ1
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

8355:lonp1.L
gene id: 8355:lonp1.L
uniprot id: A0A1L8HXB6
uniprot id: A0A974I3F2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: Homohexamer or homoheptamer. Organized in a ring with a central cavity.
messages: Mitochondrion matrix

8355:tuba1cl.3.L
gene id: 8355:tuba1cl.3.L
uniprot id: Q7ZYU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

8355:pde7a.S
gene id: 8355:pde7a.S
uniprot id: A0A1L8FT78
uniprot id: A0A8J1L2R7
uniprot id: A0A974HEC3
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8355:LOC121401453
gene id: 8355:LOC121401453
uniprot id: A0A8J1ML06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8355:fxyd6.S
gene id: 8355:fxyd6.S
uniprot id: A0A974CCA5
uniprot id: Q6DJD6
names: Similarity
messages: Belongs to the FXYD family.

8355:dlg5.L
gene id: 8355:dlg5.L
uniprot id: A0A8J0TVT4
uniprot id: A0A8J0U321
uniprot id: A0A8J0U3I4
uniprot id: A0A8J0U4B5
uniprot id: A0A8J0U6B1
names: Subcellular Location Annotation
messages: Cytoplasm

8355:grhpr.1.L
gene id: 8355:grhpr.1.L
uniprot id: Q6NTU8
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

8355:nt5dc2.S
gene id: 8355:nt5dc2.S
uniprot id: A0A1L8F224
uniprot id: A0A8J1LN92
uniprot id: A0A974H5K9
uniprot id: Q6DFB3
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

8355:shmt2.L
gene id: 8355:shmt2.L
uniprot id: A0A974DS03
uniprot id: Q6AXB3
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

8355:brd4.S
gene id: 8355:brd4.S
uniprot id: Q08D75
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters (By similarity).
messages: Chromosome
messages: Nucleus
messages: The 2 bromo domains mediate specific binding to acetylated histones. The exact combination of modified histone tails required to recruit brd4 to target genes is still unclear. The first bromo domain has high affinity for acetylated histone H4 tail, whereas the second bromo domain recognizes multiply acetylated marks in histone H3 (By similarity).

8355:LOC108715905
gene id: 8355:LOC108715905
uniprot id: A0A8J0V856
uniprot id: A0A8J1KLT3
names: Subcellular Location Annotation
messages: Membrane

8355:aldh9a1.S
gene id: 8355:aldh9a1.S
uniprot id: A0A974CZX0
uniprot id: Q7ZXX4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

8355:irf2bpl.S
gene id: 8355:irf2bpl.S
uniprot id: Q6PCG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

8355:thbd.S
gene id: 8355:thbd.S
uniprot id: A0A1L8G612
uniprot id: A0A974CTE6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108701954
gene id: 8355:LOC108701954
uniprot id: A0A8J0TZQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108704044
gene id: 8355:LOC108704044
uniprot id: A0A8J0U3P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:LOC108707504
gene id: 8355:LOC108707504
uniprot id: A0A8J1M9Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8355:wdr1.L
gene id: 8355:wdr1.L
uniprot id: Q9W7F2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat AIP1 family.
messages: Cell membrane
messages: Expressed both maternally and zygotically with expression levels remaining constant throughout development.
messages: Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Doesn't sever actin filaments alone, but caps the barbed ends of filaments severed by cofilin, which blocks annealing and depolymerization and allows more extensive severing by cofilin.
messages: Nucleus
messages: cytoskeleton

8355:atp6v0b.S
gene id: 8355:atp6v0b.S
uniprot id: A0A1L8GFV7
uniprot id: A0A974CZB9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: clathrin-coated vesicle membrane

8355:rock2.L
gene id: 8355:rock2.L
uniprot id: O73732
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by RHOA binding. Inhibited by Y-27632.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane
messages: Nucleus
messages: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.
messages: centrosome

8355:qsox1.S
gene id: 8355:qsox1.S
uniprot id: A0A8J1KJE2
uniprot id: A0A8J1KJF1
uniprot id: A0A8J1KJG2
uniprot id: A0A8J1KMI8
names: Function
names: Similarity
messages: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
messages: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.

8355:LOC121399168
gene id: 8355:LOC121399168
uniprot id: A0A8J1M003
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

8355:npc1.L
gene id: 8355:npc1.L
uniprot id: A0A1L8FYQ3
uniprot id: A0A974HGI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

8355:LOC108710165
gene id: 8355:LOC108710165
uniprot id: A0A8J1MN11
uniprot id: A0A8J1MN44
uniprot id: A0A8J1MN53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:atp13a4.L
gene id: 8355:atp13a4.L
uniprot id: A0A1L8G9U1
uniprot id: A0A974HJU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

8355:trpv1.L
gene id: 8355:trpv1.L
uniprot id: A0A1L8HD73
uniprot id: A0A8J1M7D5
uniprot id: A0A8J1M8B8
uniprot id: A0A974DN03
names: Subcellular Location Annotation
messages: Membrane

8355:ptpra.S
gene id: 8355:ptpra.S
uniprot id: A0A8J1LIJ0
uniprot id: A0A8J1LIJ5
uniprot id: A0A8J1LKV8
uniprot id: Q91556
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
messages: Cell membrane
messages: Membrane

8355:sult1c2.S
gene id: 8355:sult1c2.S
uniprot id: A0A8J1LYF5
uniprot id: Q5U5E7
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8355:LOC108716182
gene id: 8355:LOC108716182
uniprot id: A0A1L8G9Q3
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

8355:adra2c.L
gene id: 8355:adra2c.L
uniprot id: A0A1L8HT55
uniprot id: A0A974DW88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108711787
gene id: 8355:LOC108711787
uniprot id: A0A1L8H3V5
uniprot id: A0A974DF00
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:dyrk1a.L
gene id: 8355:dyrk1a.L
uniprot id: A0A1L8HCE8
uniprot id: A0A974DLA9
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

8355:LOC108695727
gene id: 8355:LOC108695727
uniprot id: A0A1L8FIK6
uniprot id: A0A974CEF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:rab5if.L
gene id: 8355:rab5if.L
uniprot id: A0A974BXX1
uniprot id: Q6DE34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:LOC121401199
gene id: 8355:LOC121401199
uniprot id: A0A8J1MIY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:arpc4.S
gene id: 8355:arpc4.S
uniprot id: Q641G7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:17178911). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:17178911). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (Probable). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).
messages: Belongs to the ARPC4 family.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of actr2/arp2, actr3/arp3, arpc1 (arpc1a or arpc1b), arpc2, arpc3, arpc4 and arpc5.
messages: Nucleus
messages: cytoskeleton

8355:efemp1.L
gene id: 8355:efemp1.L
uniprot id: A0A1L8G759
uniprot id: A0A974HJ47
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108698841
gene id: 8355:LOC108698841
uniprot id: A0A1L8F5M6
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

8355:KEF37 p13
gene id: 8355:KEF37_p13
uniprot id: P03890
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

8355:il18rap.L
gene id: 8355:il18rap.L
uniprot id: A0A8J0UEG2
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

8355:h2ax.2.L
gene id: 8355:h2ax.2.L
uniprot id: A0A1L8FLH3
uniprot id: A0A974CFP4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:arhgap19.L
gene id: 8355:arhgap19.L
uniprot id: Q6INE5
names: Function
messages: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

8355:acvr2a.S
gene id: 8355:acvr2a.S
uniprot id: A0A8J1LW64
uniprot id: A0A8J1LW81
uniprot id: Q9PSM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

8355:ezh1.L
gene id: 8355:ezh1.L
uniprot id: A0A1L8ETS0
uniprot id: A0A974H2R5
names: Subcellular Location Annotation
messages: Nucleus

8355:smoc1.L
gene id: 8355:smoc1.L
uniprot id: A0A1L8FAJ5
uniprot id: A0A8J0T831
uniprot id: A0A8J0TFX3
uniprot id: A0A8J0TGR9
uniprot id: A0A8J0THH3
uniprot id: A0A8J1LEE2
uniprot id: A0A974C8H0
uniprot id: B8PXJ7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108696036
gene id: 8355:LOC108696036
uniprot id: A0A8J1L9B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8355:slc26a11.L
gene id: 8355:slc26a11.L
uniprot id: A0A1L8ETJ1
uniprot id: A0A8J0TTG3
uniprot id: A0A8J0TUJ5
uniprot id: A0A8J1LTU8
uniprot id: A0A974BXA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

8355:LOC108711149
gene id: 8355:LOC108711149
uniprot id: A0A8J0UR89
names: Subcellular Location Annotation
messages: cytoskeleton
messages: sarcomere

8355:nqo1.L
gene id: 8355:nqo1.L
uniprot id: A0A8J0UYD8
uniprot id: A5D8M8
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

8355:acat1.S
gene id: 8355:acat1.S
uniprot id: Q6GN02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Homotetramer.
messages: Mitochondrion
messages: This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism.

8355:LOC108696031
gene id: 8355:LOC108696031
uniprot id: A0A8J0T705
uniprot id: A0A8J1L9B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8355:cnih3.L
gene id: 8355:cnih3.L
uniprot id: A0A1L8G6F3
uniprot id: A0A974CU82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

8355:ednrb2.S
gene id: 8355:ednrb2.S
uniprot id: Q7ZWK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:gpr18.L
gene id: 8355:gpr18.L
uniprot id: A0A1L8HH77
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:tmem115.S
gene id: 8355:tmem115.S
uniprot id: A0A974D315
uniprot id: B1H1R4
names: Subcellular Location Annotation
messages: Membrane

8355:tprg1.L
gene id: 8355:tprg1.L
uniprot id: A0A974CXQ6
uniprot id: Q6P416
names: Similarity
messages: Belongs to the TPRG1 family.

8355:dus3l.L
gene id: 8355:dus3l.L
uniprot id: A0A974HF42
uniprot id: Q7ZWS1
names: Function
names: Similarity
messages: Belongs to the Dus family. Dus3 subfamily.
messages: Belongs to the dus family. Dus3 subfamily.
messages: Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs. Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation.

8355:LOC108717207
gene id: 8355:LOC108717207
uniprot id: A0A1L8GBZ5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:pmepa1.L
gene id: 8355:pmepa1.L
uniprot id: A0A8J0TQ97
uniprot id: D2KUZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: May function as a negative regulator of TGF-beta signaling and thereby inhibits activin-mediated mesoderm formation.
messages: Membrane

8355:LOC108712484
gene id: 8355:LOC108712484
uniprot id: A0A1L8GU19
uniprot id: A0A974D8T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8355:gtf2ird1.L
gene id: 8355:gtf2ird1.L
uniprot id: A0A1L8HG89
uniprot id: A0A8J1M923
uniprot id: A0A8J1MA35
uniprot id: A0A8J1MAV9
uniprot id: A0A974DN96
names: Subcellular Location Annotation
messages: Nucleus

8355:gper1.S
gene id: 8355:gper1.S
uniprot id: A0A1L8EQD0
uniprot id: A0A974H1P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C.

8355:drgx.S
gene id: 8355:drgx.S
uniprot id: A0A8J0TF21
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC121400483
gene id: 8355:LOC121400483
uniprot id: A0A8J1MCX6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC121401257
gene id: 8355:LOC121401257
uniprot id: A0A8J1MKG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108695734
gene id: 8355:LOC108695734
uniprot id: A0A1L8FIL5
uniprot id: A0A974CEX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:cutc.L
gene id: 8355:cutc.L
uniprot id: A0A974HBS8
uniprot id: Q32NG2
names: Similarity
messages: Belongs to the CutC family.

8355:kcnab3.L
gene id: 8355:kcnab3.L
uniprot id: A0A1L8H3C4
uniprot id: A0A8J1MPD2
uniprot id: Q9PTM4
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters functional properties of Kv1.1 and Kv1.2.
messages: Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit.
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cytoplasm
messages: Expression first detected in brain and most anterior regions of spinal cord at embryonic stage 24 (26 hours). By stage 29 (35 hours) expression is also detected in posterior regions of spinal cord.
messages: Forms heteromultimeric complex with alpha subunits.

8355:paqr6.L
gene id: 8355:paqr6.L
uniprot id: A0A974CA98
uniprot id: Q52L08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

8355:calr3.S
gene id: 8355:calr3.S
uniprot id: A0A1L8GG47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

8355:flnc.L
gene id: 8355:flnc.L
uniprot id: A0A1L8GZU4
uniprot id: A0A8J1ML92
uniprot id: A0A8J1MM93
uniprot id: A0A8J1MNB1
uniprot id: A0A974DE31
names: Similarity
messages: Belongs to the filamin family.

8355:slc2a2.L
gene id: 8355:slc2a2.L
uniprot id: A0A974CWN4
uniprot id: Q6IRN8
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

8355:cryg1
gene id: 8355:cryg1
uniprot id: Q06254
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Monomer.

8355:mpz.S
gene id: 8355:mpz.S
uniprot id: A0A8J0QFM7
uniprot id: A2VD98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin P0 protein family.
messages: Cell membrane
messages: Creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae.
messages: Membrane

8355:ifitm1.L
gene id: 8355:ifitm1.L
uniprot id: A0A1L8GJ50
uniprot id: A0A974D455
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8355:ptmap12.S
gene id: 8355:ptmap12.S
uniprot id: A0A1L8FGB5
uniprot id: A0A974HAB4
names: Similarity
messages: Belongs to the pro/parathymosin family.

8355:cdip1.L
gene id: 8355:cdip1.L
uniprot id: Q8AVW3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Late endosome membrane
messages: Lysosome membrane
messages: May act as a p53/TP53-apoptotic effector.
messages: The LITAF domain is stabilized by a bound zinc ion. The LITAF domain contains an amphipathic helix that mediates interaction with lipid membranes.

8355:MGC68456
gene id: 8355:MGC68456
uniprot id: Q6PAE2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:sh3bp5.L
gene id: 8355:sh3bp5.L
uniprot id: A0A1L8FWJ1
uniprot id: A0A974HFR7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

8355:42sp50.L
gene id: 8355:42sp50.L
uniprot id: A4FVE0
uniprot id: P17506
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 3 EF-1-alpha are expressed under different developmental control in Xenopus laevis. This protein is expressed exclusively in immature oocytes.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: The 42S RNP particle comprises four subunits each of which contains one molecule of 5S RNA, three molecules of tRNA, two molecules of EF1-alpha and one molecule of the 5S RNA binding protein 43.
messages: This protein is one of two protein components of a 42S RNP particle that is very abundant in previtellogenic oocytes. A major function served by 42sp50 appears to be the storage of tRNAs for later use in oogenesis and early embryogenesis. Purified 42S particles can directly transfer aminoacyl tRNA to ribosomes.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

8355:oxsr1.L
gene id: 8355:oxsr1.L
uniprot id: A0A974HEX0
uniprot id: A0JPG0
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

8355:XB5913757.L
gene id: 8355:XB5913757.L
uniprot id: A0A1L8FMX1
uniprot id: A0A8J1L795
uniprot id: A0A974CHS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM11 family.
messages: Membrane
messages: Plays a role in mitochondrial morphogenesis.

8355:sebox.L
gene id: 8355:sebox.L
uniprot id: A0A1L8HDA6
uniprot id: A0A974HXQ4
names: Subcellular Location Annotation
messages: Nucleus

8355:nsun6.L
gene id: 8355:nsun6.L
uniprot id: A0A8J1KW45
uniprot id: A0A8J1KW48
uniprot id: A0A8J1KXR8
uniprot id: A0A8J1KZ44
uniprot id: Q0IHJ9
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:fabp1.S
gene id: 8355:fabp1.S
uniprot id: A0A1L8HKR9
uniprot id: A0A974DTA2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

8355:hes1.S
gene id: 8355:hes1.S
uniprot id: Q8AVU4
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
messages: Nucleus
messages: The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
messages: The bHLH, as well as cooperation between the central Orange domain and the C-terminal WRPW motif, is required for transcriptional repressor activity.
messages: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family. Interacts with the bHLH protein hes2, and binds DNA in the form of a heterodimer with the bHLH protein hey1/hrt1. Interacts with the bHLH protein hes6; this interaction may inhibit the transcriptional repressor activity (By similarity).
messages: Transcriptional repressor of a subset of early mesodermal genes including myod1 and t/bra. Binds DNA on N-box motifs: 5'-CACNAG-3'. Acts as a negative regulator of myogenesis, mediating Notch signaling to repress expression of myod1 (By similarity).

8355:LOC121394547
gene id: 8355:LOC121394547
uniprot id: A0A8J1KX40
uniprot id: A0A8J1L061
names: Subcellular Location Annotation
messages: Membrane

8355:sass6.2.L
gene id: 8355:sass6.2.L
uniprot id: A0A1L8GN37
uniprot id: A0A8J0V1T6
uniprot id: A0A8J1MZS3
uniprot id: A0A974D447
names: Subcellular Location Annotation
messages: centrosome

8355:pltp.L
gene id: 8355:pltp.L
uniprot id: A0A1L8ETW4
uniprot id: A0A974BXR0
names: Similarity
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

8355:aff4.L
gene id: 8355:aff4.L
uniprot id: A0A1L8GXN0
uniprot id: A0A8J0UTF0
uniprot id: A0A974DCN5
names: Similarity
messages: Belongs to the AF4 family.

8355:arl5c.L
gene id: 8355:arl5c.L
uniprot id: A0A974BX35
uniprot id: Q7ZXC2
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

8355:ndc1.S
gene id: 8355:ndc1.S
uniprot id: A0A8J0V925
uniprot id: A0A8J1N285
uniprot id: A0A974HM69
uniprot id: Q6AX31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDC1 family.
messages: Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.
messages: Membrane
messages: Nucleus membrane
messages: nuclear pore complex

8355:nnt.L
gene id: 8355:nnt.L
uniprot id: A0A974E2F3
uniprot id: Q66J07
names: Similarity
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

8355:dhx15.S
gene id: 8355:dhx15.S
uniprot id: A0A1L8HKX4
uniprot id: A0A8J0U7U0
uniprot id: A0A974I0C3
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.

8355:ncdn.S
gene id: 8355:ncdn.S
uniprot id: A0A8J1MC34
uniprot id: Q640K1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurochondrin family.
messages: Postsynapse
messages: Probably involved in signal transduction, in the nervous system. Required for the spatial learning process. May also be involved in neurite outgrowth (By similarity).
messages: cytosol
messages: dendrite

8355:setd2.S
gene id: 8355:setd2.S
uniprot id: A0A8J1L133
uniprot id: A0A8J1L150
uniprot id: A0A8J1L2P7
names: Subcellular Location Annotation
messages: Nucleus

8355:sf3b4.L
gene id: 8355:sf3b4.L
uniprot id: A0A8J1LEM3
uniprot id: A0A974CAI0
uniprot id: Q6AZR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B4 family.
messages: Nucleus

8355:pmvk.L
gene id: 8355:pmvk.L
uniprot id: A0A1L8FDC1
uniprot id: A0A974CAM2
uniprot id: Q3KPY7
names: Subcellular Location Annotation
messages: cytosol

8355:pick1.L
gene id: 8355:pick1.L
uniprot id: A0A8J0UZU0
uniprot id: A0A8J1MWK8
uniprot id: A0A974D5U9
uniprot id: Q32NG7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
messages: cytoskeleton
messages: perinuclear region
messages: synaptosome

8355:atxn1l.S
gene id: 8355:atxn1l.S
uniprot id: A0A974D0X6
uniprot id: B1WBC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

8355:fnip2.S
gene id: 8355:fnip2.S
uniprot id: A0A1L8HLQ8
uniprot id: A0A8J0U854
uniprot id: A0A8J0UAV3
uniprot id: A0A974DTK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

8355:tmem199.L
gene id: 8355:tmem199.L
uniprot id: A0A974HXK0
uniprot id: Q3B8B0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:LOC121394548
gene id: 8355:LOC121394548
uniprot id: A0A8J1KX40
uniprot id: A0A8J1L016
uniprot id: A0A8J1L061
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108715046
gene id: 8355:LOC108715046
uniprot id: A0A8J1KK48
names: Similarity
messages: Belongs to the copine family.

8355:copg2.S
gene id: 8355:copg2.S
uniprot id: A0A8J1MQ50
uniprot id: Q6DKD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

8355:gas2l2.S
gene id: 8355:gas2l2.S
uniprot id: A0A1L8H8C0
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAS2 family.
messages: Due to the high similarity between gas2l2.L and gas2l2.S, the morpholinos used for knockdown target both gas2l2.L and gas2l2.S RNA.
messages: Morpholino knockdown of both gas2l2.L and gas2l2.s resulted in mosiac embryos and impacted the number and distribution of basal bodies on the surface of ciliated cells (PubMed:30665704). As a result, ciliary orientation was significantly reduced (PubMed:30665704).
messages: Together with gas2l2.L, regulates ciliary orientation and performance.
messages: cilium basal body
messages: cytoskeleton

8355:LOC108701972
gene id: 8355:LOC108701972
uniprot id: A0A1L8EZE5
uniprot id: A0A974C2H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108702339
gene id: 8355:LOC108702339
uniprot id: A0A8J0TR28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8355:MGC146850.L
gene id: 8355:MGC146850.L
uniprot id: A0A8J1MXF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:pex19.L
gene id: 8355:pex19.L
uniprot id: A0A974H938
uniprot id: Q0IH62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-19 family.
messages: Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.
messages: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
messages: Peroxisome membrane

8355:get4.L
gene id: 8355:get4.L
uniprot id: Q6NRL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of a cytosolic protein quality control complex, the bag6/bat3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The bag6/bat3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Similarly, the bag6/bat3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The bag6/bat3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.
messages: Belongs to the GET4 family.
messages: Component of the bag6/bat3 complex.
messages: cytosol

8355:LOC108695707
gene id: 8355:LOC108695707
uniprot id: A0A8J1L984
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8355:hoxb9.L
gene id: 8355:hoxb9.L
uniprot id: A0A1L8ES24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

8355:nemp1.S
gene id: 8355:nemp1.S
uniprot id: A0A8J1MDN1
uniprot id: B9X187
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NEMP family.
messages: Expressed both maternally and zygotically. At the early gastrula stage, expressed mainly in the entire animal hemisphere. During neurulation, its expression becomes restricted to the anterior neuroectoderm. At the tailbud stage, expressed in various anterior regions including the anterior central nervous system (CNS), otic vesicles and branchial arches.
messages: Homooligomer. Interacts with banf1-a and banf1-b. Interacts with ran-gtp.
messages: In concert with ran, required for proper eye development (PubMed:25946333). May be involved in the expression of early eye marker genes (PubMed:19167377). Contributes to nuclear envelope stiffness in germ cells (By similarity). Required for fertility (By similarity).
messages: Morpholino knockdown results in defects in eye development, reduced expression of early eye marker genes rax, tbx3, six3 and pax6 and reduction of cell density at the neurula stage. Co-knockdown of nemp1a and ran elicits reduction of cell density and eye defects more significantly than the individual knockdown of either one.
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Phosphorylated.
messages: The transmembrane domains are required and sufficient for its oligomerization.

8355:oxa1l.L
gene id: 8355:oxa1l.L
uniprot id: A0A1L8HYQ8
uniprot id: A0A974DZZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

8355:peli2.S
gene id: 8355:peli2.S
uniprot id: A0A974C1K1
uniprot id: Q6GQ57
names: Similarity
messages: Belongs to the pellino family.

8355:taf4b.S
gene id: 8355:taf4b.S
uniprot id: A0A1L8FSU7
uniprot id: A0A8J1L2M2
uniprot id: A0A974CK23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF4 family.
messages: Nucleus

8355:pbx3.S
gene id: 8355:pbx3.S
uniprot id: A0A1L8F1R5
uniprot id: A0A8J0TQ62
uniprot id: A0A8J1LMB6
uniprot id: A0A974C3G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

8355:fshb.S
gene id: 8355:fshb.S
uniprot id: A0A1L8GDH0
uniprot id: A0A974CYS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

8355:bhmt.L
gene id: 8355:bhmt.L
uniprot id: A0A8J1M8F5
uniprot id: Q5XGM3
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.
messages: Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity).

8355:slit1.S
gene id: 8355:slit1.S
uniprot id: Q7ZXI2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:LOC121402248
gene id: 8355:LOC121402248
uniprot id: A0A8J1MSM0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:brca1.L
gene id: 8355:brca1.L
uniprot id: Q90X96
names: Subcellular Location Annotation
messages: Chromosome

8355:sstr1.L
gene id: 8355:sstr1.L
uniprot id: A0A1L8FAQ3
uniprot id: A0A974H8E4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:alb.S
gene id: 8355:alb.S
uniprot id: Q642P7
names: Subcellular Location Annotation
messages: Secreted

8355:LOC108708683
gene id: 8355:LOC108708683
uniprot id: A0A1L8HIT8
uniprot id: A0A974HZE4
names: Subcellular Location Annotation
messages: Membrane

8355:grhl1.S
gene id: 8355:grhl1.S
uniprot id: A0A1L8G554
uniprot id: A0A8J0VGK6
uniprot id: A0A8J0VGL1
uniprot id: A0A8J0VHM0
uniprot id: A0A8J0VLY5
uniprot id: A0A8J0VLZ0
uniprot id: A0A974CSS8
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC121398090
gene id: 8355:LOC121398090
uniprot id: A0A1L8G0S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:tmem35b.L
gene id: 8355:tmem35b.L
uniprot id: A0A8J0UF80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

8355:LOC108699846
gene id: 8355:LOC108699846
uniprot id: A0A8J0TNI4
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

8355:chchd4.S
gene id: 8355:chchd4.S
uniprot id: A0A1L8GHQ5
uniprot id: A0A8J1MZK3
uniprot id: A0A974D360
uniprot id: Q63ZK1
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes (By similarity). Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17 or MICU1. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria.
messages: Mitochondrion intermembrane space
messages: Monomer. Can form homooligomers.
messages: The CHCH domain contains a conserved twin Cys-X(9)-Cys motif which is required for import and stability of MIA40 in mitochondria.

8355:e2f8.L
gene id: 8355:e2f8.L
uniprot id: A0A8J1MV02
uniprot id: Q32NV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

8355:LOC108713505
gene id: 8355:LOC108713505
uniprot id: A0A8J1MZQ6
names: Similarity
messages: Belongs to the DCK/DGK family.

8355:LOC108707492
gene id: 8355:LOC108707492
uniprot id: A0A8J0UCS1
uniprot id: A0A8J1M8G0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.

8355:slc25a30.S
gene id: 8355:slc25a30.S
uniprot id: A0A1L8H9C4
uniprot id: A0A8J0ULF1
uniprot id: A0A974DIN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8355:LOC108704600
gene id: 8355:LOC108704600
uniprot id: A0A8J0U7V3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

8355:LOC108713228
gene id: 8355:LOC108713228
uniprot id: A0A1L8GUZ9
uniprot id: A0A974HRS2
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

8355:atp6v1b2.S
gene id: 8355:atp6v1b2.S
uniprot id: A0A974D7D0
uniprot id: Q7ZTJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

8355:LOC108699032
gene id: 8355:LOC108699032
uniprot id: A0A8J0TLD8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:myoz1.L
gene id: 8355:myoz1.L
uniprot id: Q7SYY0
names: Similarity
messages: Belongs to the myozenin family.

8355:nagk.L
gene id: 8355:nagk.L
uniprot id: B4F6R2
names: Similarity
messages: Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

8355:LOC121393574
gene id: 8355:LOC121393574
uniprot id: A0A8J1KLZ7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:xkr5.L
gene id: 8355:xkr5.L
uniprot id: A0A8J0VCM7
uniprot id: A0A8J0VDW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

8355:bicd2l.L
gene id: 8355:bicd2l.L
uniprot id: A0A974C698
uniprot id: Q5FWL8
names: Similarity
messages: Belongs to the BicD family.

8355:myh9.S
gene id: 8355:myh9.S
uniprot id: A0A1L8GGP5
uniprot id: A0A974HLZ4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8355:cldn17.1.L
gene id: 8355:cldn17.1.L
uniprot id: A0A1L8HCQ4
uniprot id: A0A974DNB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8355:c9.L
gene id: 8355:c9.L
uniprot id: A0A8J0VC26
uniprot id: A0A8J0VG71
uniprot id: A0A8J1N0U6
uniprot id: Q7SYA0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:plaa.S
gene id: 8355:plaa.S
uniprot id: A0A8J0U1A6
uniprot id: A0A8J0U8C4
uniprot id: A0A974I1E9
uniprot id: Q6GM65
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PLAP family.
messages: Cytoplasm
messages: Nucleus
messages: Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis.
messages: Synapse
messages: The PFU domain mediates interaction with ubiquitin.
messages: The PUL domain is composed of 6 armadillo-like repeats and mediates the interaction with VCP C-terminus.

8355:LOC121400544
gene id: 8355:LOC121400544
uniprot id: A0A8J1MEK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

8355:LOC108697330
gene id: 8355:LOC108697330
uniprot id: A0A1L8FDU1
uniprot id: A0A974H9P7
names: Similarity
messages: Belongs to the RimK family.

8355:polm.S
gene id: 8355:polm.S
uniprot id: A0A8J0UUY7
uniprot id: A0A8J1MQP2
uniprot id: A0A8J1MRJ3
uniprot id: A0A8J1MSS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ).
messages: Nucleus

8355:LOC108700278
gene id: 8355:LOC108700278
uniprot id: A0A8J0TP70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:c11orf49.L
gene id: 8355:c11orf49.L
uniprot id: A0A1L8GIP5
uniprot id: A0A974D1C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSTPP1 family.
messages: cytoskeleton

8355:atp6v1g2.L
gene id: 8355:atp6v1g2.L
uniprot id: A0A1L8F8G8
uniprot id: A0A974C8H3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

8355:lmbrd1.L
gene id: 8355:lmbrd1.L
uniprot id: Q7SYR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIMR family. LMBRD1 subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors. Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome. Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (By similarity). May play a role in mediating and regulating the internalization of the insulin receptor (By similarity).
messages: Lysosome membrane

8355:cdc42bpa.S
gene id: 8355:cdc42bpa.S
uniprot id: A0A8J0VJY9
uniprot id: A0A8J1KS61
uniprot id: A0A8J1KS78
uniprot id: A0A8J1KTT1
uniprot id: A0A8J1KV99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: lamellipodium

8355:LOC121394464
gene id: 8355:LOC121394464
uniprot id: A0A8J1KXU3
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:arfgap1l.L
gene id: 8355:arfgap1l.L
uniprot id: A0A8J1MAH0
uniprot id: A0A8J1MC84
uniprot id: A0A8J1MC89
names: Subcellular Location Annotation
messages: Cytoplasm

8355:tspan17.S
gene id: 8355:tspan17.S
uniprot id: Q6NRM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8355:ess2.L
gene id: 8355:ess2.L
uniprot id: A0A1L8I0I5
uniprot id: A0A8J1L065
uniprot id: A0A974E2T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESS2 family.
messages: Nucleus

8355:pappa2.L
gene id: 8355:pappa2.L
uniprot id: A0A8J1MX21
names: Caution
names: Similarity
messages: Belongs to the peptidase M43B family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108700335
gene id: 8355:LOC108700335
uniprot id: A0A1L8F4H7
uniprot id: A0A974H6C5
names: Similarity
messages: Belongs to the peptidase C1 family.

8355:ndufab1.S
gene id: 8355:ndufab1.S
uniprot id: A0A1L8EQU3
uniprot id: A0A974BVS8
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

8355:LOC121394486
gene id: 8355:LOC121394486
uniprot id: A0A8J1KXW6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:appl2.L
gene id: 8355:appl2.L
uniprot id: A0A974DDK2
uniprot id: Q642Q2
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: Nucleus
messages: phagosome
messages: ruffle

8355:gosr2.L
gene id: 8355:gosr2.L
uniprot id: A0A1L8ESM2
uniprot id: A0A8J0TUF0
uniprot id: A0A974BWJ0
uniprot id: Q6DDU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOSR2 family.
messages: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
messages: Membrane

8355:hkdc1.S
gene id: 8355:hkdc1.S
uniprot id: A0A1L8GS61
uniprot id: A0A974D8K3
names: Similarity
messages: Belongs to the hexokinase family.

8355:rtn1.S
gene id: 8355:rtn1.S
uniprot id: A0A8J0TMS6
uniprot id: Q5MY90
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Endoplasmic reticulum membrane
messages: Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity.
messages: Isoform A and isoform C are both expressed in the animal hemisphere (presumptive neural ectoderm) of blastula and gastrula stage embryos, and along the anterior neural border, in the panplacodal primordium, and in the dorsolateral side of archenteron roof of late neurula embryos. At the tailbud stage, expression of the isoforms begin to differ. Isoform A localizes to the cranial placodes including the trigeminal placode, lateral line placode, olfactory placode and otic vesicle. Isoform C localizes to the central nervous system, including the spinal cord, prosencephalon, mesencephalon and rhombencephalon, as well as the lateral line placode, otic vesicle and pronephros.
messages: Isoform A and isoform C are expressed both maternally and zygotically.
messages: Isoform A is repressed by thyroid hormone.
messages: Membrane
messages: Nucleus

8355:MGC81040
gene id: 8355:MGC81040
uniprot id: Q6NUD5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.

8355:top1.1.L
gene id: 8355:top1.1.L
uniprot id: A0A1L8EU24
uniprot id: A0A974H3B9
uniprot id: P41512
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type IB topoisomerase family.
messages: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.
messages: Monomer.
messages: Nucleus
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. TThe free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. May play a role in the circadian transcription of the core circadian clock component BMAL1.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

8355:fgf9.S
gene id: 8355:fgf9.S
uniprot id: Q91875
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the heparin-binding growth factors family.
messages: Glycosylated.
messages: Maternal transcript is found mainly in the animal hemisphere. Zygotic transcript is found around the blastopore and in the late gastrula stage, in the dorsal part. In later stages it is found along the dorsal part and head region.
messages: May have a role in muscle development and neural differentiation, has no specific role in anteroposterior patterning.
messages: Secreted
messages: The maternal protein is detected up to the blastula stage but declines by the early glastrula. Zygotic expression starts at around early gastrula; the level of expression reached at stage 15 persists during neurula and tailbud stages, and is further increased during the tadpole stages.

8355:ddr1.L
gene id: 8355:ddr1.L
uniprot id: A0A8J0T8I1
uniprot id: A0A974C7D2
uniprot id: Q6P9I0
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108711407
gene id: 8355:LOC108711407
uniprot id: A0A1L8H0M7
uniprot id: A0A8J0UK58
uniprot id: A0A8J0UR58
uniprot id: A0A8J0US98
uniprot id: A0A8J1MLW5
uniprot id: A0A8J1MMS5
uniprot id: A0A8J1MNW4
uniprot id: A0A974DD53
names: Subcellular Location Annotation
messages: Membrane

8355:psmc2.S
gene id: 8355:psmc2.S
uniprot id: A0A1L8GTU4
uniprot id: A0A974HRG8
names: Similarity
messages: Belongs to the AAA ATPase family.

8355:slc26a6.2.L
gene id: 8355:slc26a6.2.L
uniprot id: Q6DJN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

8355:pou3f2.L
gene id: 8355:pou3f2.L
uniprot id: A0A974CV61
uniprot id: P70030
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Expressed in the developing brain and spinal cord. Also found in a restricted region of the auditory vesicle during development. In the adult, expression is restricted to the brain.
messages: First expressed at the neurula stage.
messages: Nucleus
messages: Transcription factor that may be implicated in patterning of the central nervous system during early development.

8355:LOC100037108
gene id: 8355:LOC100037108
uniprot id: A0A8J0U8J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synuclein family.
messages: Membrane
messages: Nucleus
messages: Secreted
messages: Synapse

8355:prmt1.L
gene id: 8355:prmt1.L
uniprot id: A0A8J0T881
uniprot id: A0A8J0T883
uniprot id: A0A974HCP6
uniprot id: Q6VRB0
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in target proteins. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation (By similarity). Methylates ilf3 to regulate its DNA-binding activity (PubMed:18636753). Required for neural induction, playing a key role in the control of epidermal versus neural cell fate choice (PubMed:16214893).
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
messages: By Ca(2+).
messages: Cytoplasm
messages: Expressed both maternally and zygotically. Expressed throughout all embryonic stages.
messages: From the onset of gastrulation, expressed in dorsal mesoderm, and in dorsal and ventral ectoderm. At the neurula and tail bud stages, expression is restricted to the neuroectoderm, with highest expression in the anterior neural plate.
messages: Homodimer. Homooctamer; individual homodimers associates to form a homooctamer and homooligomerization is required for proper localization to the cell membrane. Individual homodimers can associate to form a homohexamer (By similarity). Component of a complex with lsm14a/rap55a. Interacts with cirbp (By similarity).
messages: Nucleus
messages: cytosol
messages: nucleoplasm

8355:LOC108699022
gene id: 8355:LOC108699022
uniprot id: A0A8J1LKS0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:htr1a.S
gene id: 8355:htr1a.S
uniprot id: A0A8J0U5K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:nos2.L
gene id: 8355:nos2.L
uniprot id: A0A8J0UGX9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.

8355:sdc4.L
gene id: 8355:sdc4.L
uniprot id: Q1AGV6
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan. Regulates non-canonical Wnt signaling, being necessary and sufficient for fibronectrin-mediated translocation of dvl2/dsh to the plasma membrane. Required for proper convergent extension movements during gastrulation, which shape the neural plate, and for subsequent neural tube closure.
messages: Expressed both maternally and zygotically.
messages: Expressed in the animal hemisphere from the 4-cell to the blastula stage. During gastrulation, expressed in the involuting dorsal mesoderm and ectoderm. After involution, localized mainly to the anterior neuroectoderm. At later stages, expressed in the brain, branchial arches, pronephros, tailbud, and at low levels in the somites.
messages: Interacts with the Wnt receptor fzd7 and its signal transducer dvl2/dsh.
messages: Membrane
messages: O-glycosylated; contains both chondroitin sulfate and heparan sulfate. Ser-37, Ser-73 and Ser-75 can all be modified by either chondroitin sulfate or heparan sulfate, and the protein exists in forms that contain only chondroitin sulfate, only heparan sulfate and both chondroitin sulfate and heparan sulfate.

8355:LOC108719099
gene id: 8355:LOC108719099
uniprot id: A0A1L8FXM9
uniprot id: A0A974CPG8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:borcs7.S
gene id: 8355:borcs7.S
uniprot id: A0A8J0T5U6
uniprot id: A0A8J0TDV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS7 family.
messages: Lysosome membrane
messages: Membrane

8355:myo6.S
gene id: 8355:myo6.S
uniprot id: A0A1L8G372
uniprot id: A0A8J0VCM3
uniprot id: A0A8J0VCM8
uniprot id: A0A8J0VFF2
uniprot id: A0A8J0VFF6
uniprot id: A0A8J0VFP8
uniprot id: A0A8J0VGP3
uniprot id: A0A8J0VL24
uniprot id: A0A974CRH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: clathrin-coated pit
messages: clathrin-coated vesicle
messages: filopodium
messages: microvillus
messages: ruffle membrane
messages: trans-Golgi network membrane

8355:ca12.L
gene id: 8355:ca12.L
uniprot id: A0A8J0ULE0
uniprot id: A1L3H6
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

8355:LOC121395713
gene id: 8355:LOC121395713
uniprot id: A0A8J1L8Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

8355:glul.L
gene id: 8355:glul.L
uniprot id: A0A974C5G3
uniprot id: P51121
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine.
messages: Microsome
messages: Mitochondrion
messages: cytosol

8355:ghrhr
gene id: 8355:ghrhr
uniprot id: J7FDM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

8355:arl11.S
gene id: 8355:arl11.S
uniprot id: A0A1L8HAB2
uniprot id: A0A974HWJ9
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

8355:cldn8.1.L
gene id: 8355:cldn8.1.L
uniprot id: A0A1L8HCL9
uniprot id: A0A974HXE1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8355:LOC108715166
gene id: 8355:LOC108715166
uniprot id: A0A1L8GCZ1
uniprot id: A0A974CZX2
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.

8355:rpl3l.L
gene id: 8355:rpl3l.L
uniprot id: Q640D7
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

8355:dbndd1.S
gene id: 8355:dbndd1.S
uniprot id: A0A1L8GES0
names: Similarity
messages: Belongs to the dysbindin family.

8355:XB5951253.L
gene id: 8355:XB5951253.L
uniprot id: A0A1L8HDV6
uniprot id: A0A974DN72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
messages: P-body

8355:vgll4.S
gene id: 8355:vgll4.S
uniprot id: Q6GP39
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

8355:fam171a1.L
gene id: 8355:fam171a1.L
uniprot id: A0A8J0VIY6
uniprot id: A0A974CLY9
uniprot id: Q5RJX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM171 family.
messages: Cell membrane
messages: May be involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation.
messages: Membrane

8355:snph.L
gene id: 8355:snph.L
uniprot id: A0A1L8ET82
uniprot id: A0A974BXC3
names: Subcellular Location Annotation
messages: Membrane

8355:slc13a1.L
gene id: 8355:slc13a1.L
uniprot id: A0A8J0UUE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

8355:LOC108708426
gene id: 8355:LOC108708426
uniprot id: A0A1L8HGX2
uniprot id: A0A974DNQ0
names: Similarity
messages: Belongs to the IUNH family.

8355:LOC108704388
gene id: 8355:LOC108704388
uniprot id: A0A8J1KKF8
uniprot id: A0A8J1KKG0
uniprot id: A0A8J1KKG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

8355:rasgrp1.S
gene id: 8355:rasgrp1.S
uniprot id: A0A1L8EZI4
uniprot id: A0A8J1LNK0
uniprot id: A0A974C1D8
names: Similarity
messages: Belongs to the RASGRP family.

8355:abcg1.L
gene id: 8355:abcg1.L
uniprot id: A0A1L8HCA2
uniprot id: A0A974HXE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

8355:LOC121402269
gene id: 8355:LOC121402269
uniprot id: A0A8J1MSL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8355:LOC108698646
gene id: 8355:LOC108698646
uniprot id: A0A1L8F931
uniprot id: A0A974H8B4
names: Similarity
messages: Belongs to the nesprin family.

8355:slc4a1.L
gene id: 8355:slc4a1.L
uniprot id: A0A1L8ESA0
uniprot id: A0A1L8ESA4
uniprot id: A0A8J0TRZ5
uniprot id: A0A974BWN1
uniprot id: A0A974BWS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Membrane

8355:LOC121393958
gene id: 8355:LOC121393958
uniprot id: A0A8J1KQZ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108714427
gene id: 8355:LOC108714427
uniprot id: A0A1L8GN61
names: Similarity
messages: Belongs to the PA28 family.

8355:sfrpx.S
gene id: 8355:sfrpx.S
uniprot id: A0A8J0U9H4
uniprot id: A0A8J1MBY1
uniprot id: A0A974HWX9
uniprot id: Q0IHH5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:ccn5.S
gene id: 8355:ccn5.S
uniprot id: A0A1L8ELA8
names: Similarity
messages: Belongs to the CCN family.

8355:LOC108716162
gene id: 8355:LOC108716162
uniprot id: A0A8J1KQU0
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:psen2.S
gene id: 8355:psen2.S
uniprot id: A0A8J0VE80
uniprot id: A0A974CQU9
uniprot id: O12977
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundant in early stages of oogenesis after which it is nearly constant.
messages: Belongs to the peptidase A22A family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Highest expression in ovaries and to a lesser extent in kidney, brain, eye and lung. Weak expression in testis, intestine, liver and heart. Present in trace amounts in skeletal muscle.
messages: Homodimer.
messages: Homodimer. Probable component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PS-alpha or PS-beta), nicastrin (NCSTN), APH1 and PEN2 (Probable).
messages: Membrane
messages: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (By similarity). May play a role in negative regulation of apoptotic cascades during oogenesis and embryogenesis, and in developmentally matured tissues such as brain tissue.
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: The PAL motif is required for normal active site conformation.

8355:XB5864179.L
gene id: 8355:XB5864179.L
uniprot id: A0A1L8GMA7
uniprot id: A0A974HPB1
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:cnpy3.L
gene id: 8355:cnpy3.L
uniprot id: Q6GN40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the canopy family.
messages: Endoplasmic reticulum
messages: Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for immune responses (By similarity).

8355:notch4.S
gene id: 8355:notch4.S
uniprot id: A0A8J1LNN4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

8355:pdhb.S
gene id: 8355:pdhb.S
uniprot id: Q6GR17
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

8355:ndufv1.L
gene id: 8355:ndufv1.L
uniprot id: A0A974CFC0
uniprot id: Q8AVD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 51 kDa subunit family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

8355:LOC108711793
gene id: 8355:LOC108711793
uniprot id: A0A8J0UTU8
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

8355:LOC121393595
gene id: 8355:LOC121393595
uniprot id: A0A1L8G666
uniprot id: A0A8J1KM33
names: Similarity
messages: Belongs to the acylphosphatase family.

8355:dnaja4.1.L
gene id: 8355:dnaja4.1.L
uniprot id: A0A1L8HZM9
uniprot id: A0A974E253
uniprot id: Q7SZ03
names: Subcellular Location Annotation
messages: Membrane

8355:hsd17b6.L
gene id: 8355:hsd17b6.L
uniprot id: Q6PA40
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8355:grid1.L
gene id: 8355:grid1.L
uniprot id: A0A8J1L5L2
uniprot id: A0A8J1L5L9
uniprot id: A0A8J1L5P0
uniprot id: A0A8J1L7C4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8355:LOC108709161
gene id: 8355:LOC108709161
uniprot id: A0A1L8H4U6
uniprot id: A0A8J1MDU2
uniprot id: A0A974DHL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

8355:serpini2.L
gene id: 8355:serpini2.L
uniprot id: A0A1L8GAB9
uniprot id: A0A974CWR8
names: Similarity
messages: Belongs to the serpin family.

8355:slc10a4.L
gene id: 8355:slc10a4.L
uniprot id: A0A1L8HTQ0
uniprot id: A0A974I331
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

8355:LOC121393860
gene id: 8355:LOC121393860
uniprot id: A0A1L8GBS4
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:nr5a1.L
gene id: 8355:nr5a1.L
uniprot id: A0A1L8F6D6
uniprot id: A4PCW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

8355:rsad1.L
gene id: 8355:rsad1.L
uniprot id: A0A1L8EU82
uniprot id: A0A974BY98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Mitochondrion

8355:st7.L
gene id: 8355:st7.L
uniprot id: A0A8J0UMD1
uniprot id: A0A8J0UNL2
uniprot id: Q6DDN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

8355:top1.2.S
gene id: 8355:top1.2.S
uniprot id: A0A1L8GF75
uniprot id: A0A974D190
uniprot id: Q4V7M4
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

8355:aox1.L
gene id: 8355:aox1.L
uniprot id: A0A8J0TV29
uniprot id: A0A8J1LRM0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

8355:ube2e3.S
gene id: 8355:ube2e3.S
uniprot id: Q76EZ1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8355:ing3.S
gene id: 8355:ing3.S
uniprot id: A0A1L8GU41
uniprot id: A0A8J1MTX0
uniprot id: A0A974D8U9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

8355:ndufs7.L
gene id: 8355:ndufs7.L
uniprot id: A0A8J0UET0
uniprot id: A0A974E0R9
uniprot id: Q66L03
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

8355:fgfr1.L
gene id: 8355:fgfr1.L
uniprot id: A0A1L8H273
uniprot id: A0A8J1MGX5
uniprot id: A0A974HTT8
uniprot id: Q91897
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Nucleus
messages: Vesicle
messages: cytosol

8355:stard5.S
gene id: 8355:stard5.S
uniprot id: Q3KPW3
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

8355:lpcat4.S
gene id: 8355:lpcat4.S
uniprot id: A0A974DV44
uniprot id: Q6DCK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates. Prefers long chain acyl-CoAs (C16, C18) as acyl donors (By similarity).
messages: Endoplasmic reticulum membrane

8355:zfpm1.S
gene id: 8355:zfpm1.S
uniprot id: A0A8J0TW16
uniprot id: A0A8J0U3A0
uniprot id: A0A8J0U3S3
uniprot id: A0A8J0U4J7
uniprot id: A0A8J0U6K1
names: Subcellular Location Annotation
messages: Nucleus

8355:cfap206.L
gene id: 8355:cfap206.L
uniprot id: A0A8J0VC76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP206 family.
messages: cilium axoneme

8355:arhgef1.L
gene id: 8355:arhgef1.L
uniprot id: A0A8J1L7D3
uniprot id: A0A8J1L7E2
uniprot id: A0A8J1L920
uniprot id: A0A8J1L9Z6
names: Subcellular Location Annotation
messages: Membrane

8355:c16orf87.L
gene id: 8355:c16orf87.L
uniprot id: Q5XG50
names: Similarity
messages: Belongs to the UPF0547 family.

8355:hoxd3.S
gene id: 8355:hoxd3.S
uniprot id: A0A1L8EPE6
uniprot id: A0A974BUR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

8355:LOC121397047
gene id: 8355:LOC121397047
uniprot id: A0A8J1LI96
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:LOC108705808
gene id: 8355:LOC108705808
uniprot id: A0A8J1LM50
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

8355:LOC108708035
gene id: 8355:LOC108708035
uniprot id: A0A8J1M7U1
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC108703480
gene id: 8355:LOC108703480
uniprot id: A0A8J0U1V1
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

8355:vps72.L
gene id: 8355:vps72.L
uniprot id: Q6GNJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS72/YL1 family.
messages: Component of the NuA4 histone acetyltransferase complex.
messages: Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.
messages: Nucleus

8355:LOC108697615
gene id: 8355:LOC108697615
uniprot id: A0A1L8FG02
uniprot id: A0A974HAF2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8355:LOC108705395
gene id: 8355:LOC108705395
uniprot id: A0A8J1LGB2
uniprot id: A0A8J1LIA5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

8355:kars1.L
gene id: 8355:kars1.L
uniprot id: A0A8J0UYY4
uniprot id: Q801R2
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

8355:tbx6.L
gene id: 8355:tbx6.L
uniprot id: Q8AV66
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: At gastrulation, expressed in the lateral and ventral mesoderm. Expressed around the blastopore except at the dorsal midline. As gastrulation proceeds, expression extends anteriorly and ventrally. At the tailbud stage, expression then retracts caudally becoming restricted to the tip of the tailbud.
messages: By activin and vegt signaling, both acting via nodal. By bmp signaling in a dose-dependent manner. Fgf is necessary but not sufficient for induction.
messages: Expression begins in early gastrula embryos, reaches a peak in late gastrula to early neurula embryos (stages 13-16) and then declines until stage 30.
messages: Interacts with ripply2.2/bowline. Associates with tle4 in the presence of ripply2.2/bowline.
messages: Nucleus
messages: Transcriptional activator. Plays a role in ventral mesoderm specification and acts together with nog during muscle differentiation. Mediates posterior pattern formation of the embryo, including specification of posterior mesoderm, via activation of the Wnt and Fgf signaling pathways.

8355:ptgr2.S
gene id: 8355:ptgr2.S
uniprot id: Q5HZQ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer.

8355:icmt.S
gene id: 8355:icmt.S
uniprot id: A0A974HAB3
uniprot id: B7ZP70
uniprot id: O12947
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:smad9.L
gene id: 8355:smad9.L
uniprot id: A0A1L8HIU3
uniprot id: A0A974DQ22
uniprot id: Q8QGG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

8355:kcnt2l.S
gene id: 8355:kcnt2l.S
uniprot id: A0A8J1MSR3
uniprot id: A0A8J1MTL8
uniprot id: A0A8J1MTY0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108707191
gene id: 8355:LOC108707191
uniprot id: A0A1L8HQX6
uniprot id: A0A974I278
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

8355:kpna3.L
gene id: 8355:kpna3.L
uniprot id: A0A974DQ30
uniprot id: Q6IRB7
names: Similarity
messages: Belongs to the importin alpha family.

8355:fam8a1.S
gene id: 8355:fam8a1.S
uniprot id: A0A1L8FSF4
uniprot id: A0A974CK21
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108702272
gene id: 8355:LOC108702272
uniprot id: A0A8J1LXG7
uniprot id: A0A8J1LXG9
uniprot id: A0A8J1LXH4
uniprot id: A0A8J1LXH6
uniprot id: A0A8J1LXI0
uniprot id: A0A8J1LXI2
uniprot id: A0A8J1LXT4
uniprot id: A0A8J1LXT9
uniprot id: A0A8J1LXU6
uniprot id: A0A8J1LYS9
uniprot id: A0A8J1LYT5
uniprot id: A0A8J1LZQ0
uniprot id: A0A8J1LZQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cell membrane

8355:cdc14a.S
gene id: 8355:cdc14a.S
uniprot id: A0A1L8GGF5
uniprot id: A0A8J0VC07
uniprot id: A0A974D2D3
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

8355:dvl2.L
gene id: 8355:dvl2.L
uniprot id: A0A8J1MGW3
uniprot id: P51142
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DSH family.
messages: Can form homomultimers. Interacts with prickle1. Interacts (via PDZ domain) with ccdc88c/dal and dact1-B/dpr. Interacts (via DIX domain) with ARP/Axin-related protein and dact1-A/frodo. Interacts with sdc4, possibly via fz7. Interacts directly (via DEP domain) with efnb1/ephrin-B1 and indirectly with the phosphorylated ephrin receptors ephb1 and ephb2, via association with SH domain-containing adapters. May interact with lrrc6. Interacts with custos (via NLS1 and NLS2); the interaction is negatively regulated by Wnt stimulation (PubMed:25157132).
messages: Cell membrane
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Expressed equally in both animal-vegetal and dorsal-ventral directions of the early blastula. Becomes enriched on the dorsal side of the embryo after cortical rotation. Expressed along the anterior margin of eye field of neurulae (stage 16 embryos) and in the anterolateral crescent that borders the eye field. Continues to be expressed in the optic cup at stage 26. Expressed in the central nervous system throughout the early tailbud stage including the entire hindbrain.
messages: Expressed maternally. Most abundant in eggs and expressed at a low level in blastulae, gastrulae, neurulae and tailbud embryonic stages.
messages: Involved in at least 2 independent signaling cascades, controlling cell fate via canonical Wnt signaling and cell polarity via a planar cell polarity (PCP) cascade. Acts synergistically with dal/dapple-like to activate Wnt signaling, stabilizing ctnnb1/beta-catenin and leading to dorsal axis formation. Also prevents degradation of ctnnb1/beta-catenin by displacing gsk3 from a complex with ARP/Axin-related protein. Has an additional role in anterior-posterior (A/P) axis formation, specifying different neuroectodermal cell fates along the A/P axis in a dose-dependent manner by activating several early patterning genes. In the PCP pathway, required at the cell membrane for PCP-mediated neural and mesodermal convergent extension during gastrulation and subsequent neural tube closure, acting to activate jnk. Also involved in blastopore closure and archenteron elongation during early, but not late, gastrulation. Associates with ephrin receptors and ligands and acts as part of a downstream PCP pathway to mediate ephrin-mediated cell repulsion via activation of rhoa. Required for efnb1/ephrin-B1-driven movement of non-retinal progenitor cells into the retina during eye field formation. Patterns the hindbrain. Required for ciliogenesis. Controls the docking of basal bodies to the apical plasma membrane; mediates the activation, but not localization of rhoa at the apical surface of ciliated cells during basal body docking. Furthermore, required for the association of basal bodies with membrane-bound vesicles and the vesicle-trafficking protein exoc4/sec8, and this association is in turn required for basal body docking. Once basal bodies are docked, required for the planar polarization of basal bodies that underlies ciliary beating and the directional fluid flow across ciliated epithelia.
messages: Nucleus
messages: Phosphorylated. Phosphorylation is controlled by frizzled proteins, correlates with the onset of embryo dorsalizing events and is higher in the dorsal half of early cleavage embryos. Phosphorylated on tyrosine residues in response to association with efnb1/ephrin-B1.
messages: The C-terminal region containing the DEP domain is required for membrane accumulation and phosphorylation. Wnt signaling and axis induction requires the DIX domain. The C-terminus contributes to the localization at the cilia base.
messages: cilium

8355:LOC108709549
gene id: 8355:LOC108709549
uniprot id: A0A8J1MDX7
uniprot id: A0A8J1MFR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family. Ago subfamily.
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

8355:mif.L
gene id: 8355:mif.L
uniprot id: Q76BK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MIF family.
messages: Cytoplasm
messages: Homotrimer.
messages: Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense (By similarity). Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity. Required for normal neural development during embryogenesis.
messages: Secreted
messages: Ubiquitous. Detected throughout embryogenesis. Detected in adult spleen, liver, kidney, heart, brain, intestine, testis and lung.

8355:plxnb2.S
gene id: 8355:plxnb2.S
uniprot id: A0A1L8GU25
uniprot id: A0A8J0V163
uniprot id: A0A974HR82
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8355:parp14.3.L
gene id: 8355:parp14.3.L
uniprot id: A0A1L8HXV4
uniprot id: A0A8J1KM58
uniprot id: A0A974E173
names: Similarity
messages: Belongs to the ARTD/PARP family.

8355:tmem135.L
gene id: 8355:tmem135.L
uniprot id: Q6GQ39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM135 family.
messages: Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization.
messages: Mitochondrion membrane
messages: Peroxisome membrane

8355:mtmr11.S
gene id: 8355:mtmr11.S
uniprot id: A0A8J0TRJ2
uniprot id: A0A8J1LLK3
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

8355:LOC108708445
gene id: 8355:LOC108708445
uniprot id: A0A1L8HGX7
uniprot id: A0A8J0UIM3
uniprot id: A0A974DNT3
names: Subcellular Location Annotation
messages: Nucleus

8355:crh.S
gene id: 8355:crh.S
uniprot id: A0A1L8FT73
uniprot id: Q0GGT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

8355:c18orf21.L
gene id: 8355:c18orf21.L
uniprot id: A0A1L8FX47
uniprot id: A0A974CMF4
names: Similarity
messages: Belongs to the UPF0711 family.

8355:LOC108717233
gene id: 8355:LOC108717233
uniprot id: A0A1L8I1M8
uniprot id: A0A974I5J7
names: Subcellular Location Annotation
messages: Membrane

8355:cdc42ep1.S
gene id: 8355:cdc42ep1.S
uniprot id: A0A974HMM1
uniprot id: A8WFQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

8355:tnfaip1.L
gene id: 8355:tnfaip1.L
uniprot id: A0A8J1M8W6
names: Similarity
messages: Belongs to the BACURD family.

8355:tmem98.S
gene id: 8355:tmem98.S
uniprot id: A0A1L8EKZ0
uniprot id: A0A974BSK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM98 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: extracellular exosome

8355:megf11.L
gene id: 8355:megf11.L
uniprot id: A0A1L8H163
uniprot id: A0A8J0UKK2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC121396386
gene id: 8355:LOC121396386
uniprot id: A0A8J1LCD2
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:pole2.L
gene id: 8355:pole2.L
uniprot id: Q9DGB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase epsilon subunit B family.
messages: Nucleus
messages: Participates in DNA repair and in chromosomal DNA replication.

8355:luc7l.S
gene id: 8355:luc7l.S
uniprot id: A0A1L8EPZ6
uniprot id: A0A8J0TQK2
uniprot id: A0A974H1X0
uniprot id: Q6DJL9
names: Similarity
messages: Belongs to the Luc7 family.

8355:cavin1.L
gene id: 8355:cavin1.L
uniprot id: Q7ZWW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

8355:ephb2.S
gene id: 8355:ephb2.S
uniprot id: A0A8J0TE40
uniprot id: A0A8J1LDY8
uniprot id: A0A8J1LDZ9
uniprot id: A0A8J1LE05
uniprot id: A0A8J1LE96
uniprot id: A0A8J1LFG4
uniprot id: A0A8J1LGF0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:top2b.S
gene id: 8355:top2b.S
uniprot id: A0A1L8FRI6
uniprot id: A0A8J0VJU1
uniprot id: A0A8J0VMW7
uniprot id: A0A8J1L4F2
uniprot id: A0A974CIT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
messages: nucleolus
messages: nucleoplasm

8355:hebp2.S
gene id: 8355:hebp2.S
uniprot id: Q4ZJ76
names: Similarity
messages: Belongs to the HEBP family.

8355:wdr76.S
gene id: 8355:wdr76.S
uniprot id: Q4KLQ5
names: Function
names: Similarity
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

8355:stra6l.2.L
gene id: 8355:stra6l.2.L
uniprot id: A0A8J1KMA4
uniprot id: A0A8J1KNZ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:gsta1.S
gene id: 8355:gsta1.S
uniprot id: A0A1L8G3N9
uniprot id: A0A8J1KTM5
uniprot id: A0A974CRT3
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

8355:slc7a7.S
gene id: 8355:slc7a7.S
uniprot id: A0A1L8HPJ3
uniprot id: A0A974DTT4
names: Subcellular Location Annotation
messages: Membrane

8355:LOC121395574
gene id: 8355:LOC121395574
uniprot id: A0A8J1L6Z2
uniprot id: A0A8J1L714
uniprot id: A0A8J1L8N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0688 family.
messages: Nucleus

8355:fat4.S
gene id: 8355:fat4.S
uniprot id: A0A1L8HLV5
uniprot id: A0A974DSH3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:tmem14c.L
gene id: 8355:tmem14c.L
uniprot id: A0A974CPM4
uniprot id: Q66L20
names: Similarity
messages: Belongs to the TMEM14 family.

8355:bcor.S
gene id: 8355:bcor.S
uniprot id: A0A8J1MDA5
uniprot id: A0A8J1ME95
uniprot id: A0A8J1MF44
names: Similarity
messages: Belongs to the BCOR family.

8355:MGC84076
gene id: 8355:MGC84076
uniprot id: A0A8J1LKQ1
uniprot id: A0A974H5E1
uniprot id: Q6DKC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

8355:LOC108711202
gene id: 8355:LOC108711202
uniprot id: A0A8J1ML31
uniprot id: A0A8J1ML34
uniprot id: A0A8J1ML56
uniprot id: A0A8J1MLY3
uniprot id: A0A8J1MLZ3
uniprot id: A0A8J1MM22
uniprot id: A0A8J1MM27
uniprot id: A0A8J1MN45
uniprot id: A0A8J1MN49
names: Subcellular Location Annotation
messages: Membrane

8355:kcnj8.L
gene id: 8355:kcnj8.L
uniprot id: A0A1L8GVX8
uniprot id: A0A974DBL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

8355:traf6.S
gene id: 8355:traf6.S
uniprot id: Q3MV19
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TNF receptor-associated factor family. A subfamily.
messages: Cytoplasm
messages: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation.
messages: First detected in the neurula stage and then increased during late tadpole stage.
messages: Highly expressed in ovary and moderately expressed in kidney, spleen, stomach, colon and testis.
messages: Homotrimer (By similarity). Homooligomer (By similarity). Interacts with tifa (PubMed:16023795).
messages: Lipid droplet
messages: Nucleus
messages: The MATH/TRAF domain binds to receptor cytoplasmic domains.
messages: cell cortex

8355:nab2.L
gene id: 8355:nab2.L
uniprot id: A0A1L8HI44
uniprot id: A0A8J1MAT8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

8355:alg5.L
gene id: 8355:alg5.L
uniprot id: Q7ZXT5
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

8355:LOC108707084
gene id: 8355:LOC108707084
uniprot id: A0A1L8HQ23
uniprot id: A0A8J0UA59
uniprot id: A0A8J1M4H3
uniprot id: A0A974I1I4
names: Similarity
messages: Belongs to the RUTBC family.

8355:aspn.S
gene id: 8355:aspn.S
uniprot id: A0A1L8GH88
uniprot id: A0A974HM75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: extracellular matrix

8355:best1.L
gene id: 8355:best1.L
uniprot id: A0A1L8GJ79
uniprot id: A0A974D469
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

8355:sema3a.S
gene id: 8355:sema3a.S
uniprot id: A0A1L8GTU0
uniprot id: A0A8J0UW77
uniprot id: A0A974D9J3
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:gpr20.L
gene id: 8355:gpr20.L
uniprot id: A0A1L8G038
uniprot id: A0A974CRV1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:LOC108708732
gene id: 8355:LOC108708732
uniprot id: A0A8J0UHD6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

8355:abhd6.L
gene id: 8355:abhd6.L
uniprot id: Q7SY73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily.
messages: Late endosome membrane
messages: Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (By similarity). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (By similarity).
messages: Lysosome membrane
messages: Mitochondrion membrane

8355:ndufaf4.L
gene id: 8355:ndufaf4.L
uniprot id: Q3KQ61
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

8355:pacc1.L
gene id: 8355:pacc1.L
uniprot id: A0A1L8G6A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proton-activated chloride channel family.
messages: Cell membrane
messages: Membrane

8355:tnxb.S
gene id: 8355:tnxb.S
uniprot id: A0A8J1LNL5
uniprot id: A0A8J1LNP6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8355:LOC108711807
gene id: 8355:LOC108711807
uniprot id: A0A8J0UTW3
uniprot id: A0A8J1MQL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:foxq1.L
gene id: 8355:foxq1.L
uniprot id: A0A1L8FXS2
uniprot id: A0A974CNA6
names: Subcellular Location Annotation
messages: Nucleus

8355:cyp26c1.L
gene id: 8355:cyp26c1.L
uniprot id: A0A1L8FJ59
uniprot id: A0A974CEA3
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:LOC108699002
gene id: 8355:LOC108699002
uniprot id: A0A8J0TCQ1
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

8355:dnah11.L
gene id: 8355:dnah11.L
uniprot id: A0A8J0VGA5
names: Similarity
messages: Belongs to the dynein heavy chain family.

8355:plcd1.L
gene id: 8355:plcd1.L
uniprot id: A0A8J0VFQ6
uniprot id: A0A8J0VIF4
uniprot id: A0A8J0VND0
names: Cofactor
messages: Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.

8355:LOC108718009
gene id: 8355:LOC108718009
uniprot id: A0A8J0VCR5
uniprot id: A0A8J0VFI8
uniprot id: A0A8J0VFT2
uniprot id: A0A8J0VFT7
uniprot id: A0A8J0VGS8
uniprot id: A0A8J0VGT4
uniprot id: A0A8J0VL58
uniprot id: A0A8J1KTJ3
uniprot id: A0A8J1KTJ7
uniprot id: A0A8J1KTJ9
uniprot id: A0A8J1KTK2
uniprot id: A0A8J1KTK4
uniprot id: A0A8J1KTK5
uniprot id: A0A8J1KTK8
uniprot id: A0A8J1KTK9
uniprot id: A0A8J1KV50
uniprot id: A0A8J1KV56
uniprot id: A0A8J1KV62
uniprot id: A0A8J1KWL0
uniprot id: A0A8J1KWL5
uniprot id: A0A8J1KWM1
names: Subcellular Location Annotation
messages: cytoskeleton

8355:LOC108713233
gene id: 8355:LOC108713233
uniprot id: A0A1L8GV32
uniprot id: A0A8J0URU0
uniprot id: A0A8J0UY72
uniprot id: A0A974HRX6
names: Similarity
messages: Belongs to the lst-2 family.

8355:selenoi.S
gene id: 8355:selenoi.S
uniprot id: A0A8J0PW93
uniprot id: A0A8J0QFJ5
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

8355:LOC121401275
gene id: 8355:LOC121401275
uniprot id: A0A1L8H2C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:trabd2b.S
gene id: 8355:trabd2b.S
uniprot id: A0A1L8GFZ8
uniprot id: A0A974D213
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIKI family.
messages: Cell membrane
messages: Divalent metal cations. Mn(2+) or Co(2+).
messages: Membrane
messages: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.

8355:tulp3.L
gene id: 8355:tulp3.L
uniprot id: A0A8J1MH51
uniprot id: A0A974DB47
uniprot id: Q6DEE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

8355:csmd1-a
gene id: 8355:csmd1-a
uniprot id: A0A8J1MKV6
uniprot id: A0A8J1MKW0
uniprot id: A0A8J1MKW6
uniprot id: A0A8J1MKX1
uniprot id: A0A8J1MKX6
uniprot id: A0A8J1MKY1
uniprot id: A0A8J1MKY3
uniprot id: A0A8J1MKY7
uniprot id: A0A8J1MKY9
uniprot id: A0A8J1MKZ3
uniprot id: A0A8J1MKZ4
uniprot id: A0A8J1MKZ8
uniprot id: A0A8J1MKZ9
uniprot id: A0A8J1ML03
uniprot id: A0A8J1ML04
uniprot id: A0A8J1ML10
uniprot id: A0A8J1ML16
uniprot id: A0A8J1ML23
uniprot id: A0A8J1ML28
uniprot id: A0A8J1ML33
uniprot id: A0A8J1MLR2
uniprot id: A0A8J1MLR7
uniprot id: A0A8J1MLS3
uniprot id: A0A8J1MLS8
uniprot id: A0A8J1MLT3
uniprot id: A0A8J1MLT9
uniprot id: A0A8J1MLU6
uniprot id: A0A8J1MLV1
uniprot id: A0A8J1MLV3
uniprot id: A0A8J1MLV6
uniprot id: A0A8J1MLV9
uniprot id: A0A8J1MLW2
uniprot id: A0A8J1MLW9
uniprot id: A0A8J1MLX5
uniprot id: A0A8J1MLY1
uniprot id: A0A8J1MLY6
uniprot id: A0A8J1MLZ2
uniprot id: A0A8J1MLZ5
uniprot id: A0A8J1MM01
uniprot id: A0A8J1MMY2
uniprot id: A0A8J1MMY6
uniprot id: A0A8J1MMZ1
uniprot id: A0A8J1MMZ7
uniprot id: A0A8J1MN00
uniprot id: A0A8J1MN05
uniprot id: A0A8J1MN10
uniprot id: A0A8J1MN15
uniprot id: A0A8J1MN20
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:mogat2.2.L
gene id: 8355:mogat2.2.L
uniprot id: A0A974DQM3
uniprot id: Q2KHS5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: perinuclear region

8355:med23.L
gene id: 8355:med23.L
uniprot id: A0A8J0V4V5
uniprot id: Q6P423
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 23 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

8355:stk17a.S
gene id: 8355:stk17a.S
uniprot id: A0A974HE95
uniprot id: Q52KW9
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:ckap2.L
gene id: 8355:ckap2.L
uniprot id: A0A8J0UH27
uniprot id: A0A8J0UJN4
uniprot id: A0A8J1MBT8
names: Similarity
messages: Belongs to the CKAP2 family.

8355:crisp1.8.L
gene id: 8355:crisp1.8.L
uniprot id: A0A8J0VAC6
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:ints4.L
gene id: 8355:ints4.L
uniprot id: Q68F70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 4 family.
messages: Belongs to the multiprotein complex Integrator.
messages: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.
messages: Nucleus

8355:pdk4.L
gene id: 8355:pdk4.L
uniprot id: A0A974CLP9
uniprot id: Q7ZXU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

8355:adamts8.L
gene id: 8355:adamts8.L
uniprot id: A0A1L8FL27
uniprot id: A0A8J0T8E1
uniprot id: A0A974HBY1
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8355:nuf2.S
gene id: 8355:nuf2.S
uniprot id: A0A8J1KL67
uniprot id: Q6GQ71
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
messages: Belongs to the NUF2 family.
messages: Component of the NDC80 complex, which is composed of ndc80, cdca1, spbc24 and spbc25. The NDC80 complex interacts with mis12 and zwint (By similarity).
messages: Contaminating sequence. Potential poly-A sequence.
messages: Nucleus
messages: kinetochore

8355:LOC108716096
gene id: 8355:LOC108716096
uniprot id: A0A8J1KNP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane

8355:LOC108706710
gene id: 8355:LOC108706710
uniprot id: A0A8J0U0F3
uniprot id: A0A8J0U7I2
uniprot id: A0A8J0U8S9
uniprot id: A0A8J1M1D3
uniprot id: A0A8J1M1D8
uniprot id: A0A8J1M1E1
uniprot id: A0A8J1M1E7
uniprot id: A0A8J1M1F0
uniprot id: A0A8J1M1F4
uniprot id: A0A8J1M1F5
uniprot id: A0A8J1M1F8
uniprot id: A0A8J1M1F9
uniprot id: A0A8J1M1G3
uniprot id: A0A8J1M1G4
uniprot id: A0A8J1M1G7
uniprot id: A0A8J1M1G8
uniprot id: A0A8J1M1G9
uniprot id: A0A8J1M1H1
uniprot id: A0A8J1M1H3
uniprot id: A0A8J1M1H5
uniprot id: A0A8J1M1H6
uniprot id: A0A8J1M1I0
uniprot id: A0A8J1M1I1
uniprot id: A0A8J1M1I6
uniprot id: A0A8J1M1I7
uniprot id: A0A8J1M1J1
uniprot id: A0A8J1M1J3
uniprot id: A0A8J1M1J9
uniprot id: A0A8J1M1K2
uniprot id: A0A8J1M1K9
uniprot id: A0A8J1M1L5
uniprot id: A0A8J1M2I7
uniprot id: A0A8J1M2J4
uniprot id: A0A8J1M2K0
uniprot id: A0A8J1M2K6
uniprot id: A0A8J1M2L3
uniprot id: A0A8J1M2L9
uniprot id: A0A8J1M2M5
uniprot id: A0A8J1M2N1
uniprot id: A0A8J1M2N7
uniprot id: A0A8J1M3C8
uniprot id: A0A8J1M3D1
uniprot id: A0A8J1M3D8
uniprot id: A0A8J1M3E4
uniprot id: A0A8J1M3F5
uniprot id: A0A8J1M3G7
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

8355:foxl1.S
gene id: 8355:foxl1.S
uniprot id: A0A1L8GF40
uniprot id: A0A974CYK3
names: Subcellular Location Annotation
messages: Nucleus

8355:avp.L
gene id: 8355:avp.L
uniprot id: A0A8J0TA94
names: Similarity
messages: Belongs to the vasopressin/oxytocin family.

8355:LOC108716777
gene id: 8355:LOC108716777
uniprot id: A0A8J0VAS5
uniprot id: A0A8J1KN81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

8355:vgll4.L
gene id: 8355:vgll4.L
uniprot id: A0A8J0U4D7
uniprot id: A0A8J0U6D6
uniprot id: Q0IH83
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

8355:cdkal1.S
gene id: 8355:cdkal1.S
uniprot id: Q6NS26
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
messages: Endoplasmic reticulum membrane

8355:LOC108696259
gene id: 8355:LOC108696259
uniprot id: A0A1L8HSJ1
uniprot id: A0A974DYA0
names: Similarity
messages: Belongs to the nanos family.

8355:bco2l.L
gene id: 8355:bco2l.L
uniprot id: A0A1L8FLR5
uniprot id: A0A8J0TAX7
uniprot id: A0A8J1L6Q4
uniprot id: A0A974CI15
names: Cofactor
names: Similarity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.

8355:uckl1.S
gene id: 8355:uckl1.S
uniprot id: A0A1L8G5P9
uniprot id: A0A8J1KXV9
uniprot id: A0A974HIE4
names: Similarity
messages: Belongs to the uridine kinase family.

8355:LOC108717063
gene id: 8355:LOC108717063
uniprot id: A0A8J0VCI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane

8355:pde6b.L
gene id: 8355:pde6b.L
uniprot id: A0A1L8HVK6
uniprot id: A0A974DZ31
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8355:rxra.S
gene id: 8355:rxra.S
uniprot id: A0A1L8F189
uniprot id: A0A8J0TG25
uniprot id: A0A8J0TNS6
uniprot id: A0A8J0TPQ4
uniprot id: A0A8J1LNW6
uniprot id: A0A974C2D8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

8355:hs2st1.L
gene id: 8355:hs2st1.L
uniprot id: A0A974D4X1
uniprot id: O93336
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sulfotransferase 3 family.
messages: Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes (By similarity).
messages: Golgi apparatus membrane
messages: Homotrimer.
messages: Membrane

8355:LOC108695747
gene id: 8355:LOC108695747
uniprot id: A0A8J1LAF9
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:golph3.L
gene id: 8355:golph3.L
uniprot id: A0A974E416
uniprot id: Q5XH63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

8355:LOC108717222
gene id: 8355:LOC108717222
uniprot id: A0A8J0V9Q1
uniprot id: A0A8J0VCL1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

8355:LOC108708097
gene id: 8355:LOC108708097
uniprot id: A0A1L8HEA3
uniprot id: A0A974DM40
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

8355:laptm5.S
gene id: 8355:laptm5.S
uniprot id: A0A1L8H7M1
uniprot id: A0A8J0UJ93
uniprot id: A0A974DHE1
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

8355:LOC108714608
gene id: 8355:LOC108714608
uniprot id: A0A1L8GPB5
uniprot id: A0A974HPZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

8355:dync1i2.S
gene id: 8355:dync1i2.S
uniprot id: A0A8J0TXL0
uniprot id: A0A8J0U0J8
uniprot id: A0A8J1LVV8
uniprot id: A0A8J1LVX9
uniprot id: A0A8J1LWB5
uniprot id: A0A974H194
uniprot id: Q6NRC5
names: Similarity
messages: Belongs to the dynein intermediate chain family.

8355:sox3.L
gene id: 8355:sox3.L
uniprot id: A0A974C6D7
uniprot id: Q5FWM3
names: Caution
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with ctnnb1.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor with sequence-specific DNA binding activity. Binds to the consensus sequence 5'-[AT][AT]CAA[AT]G-3', showing a preference for 5'-AACAAT-3' and 5'-AACAAAG-3'. Inhibits beta-catenin-mediated dorsal axis specification by binding to sites within the promoter of the beta-catenin-regulated gene nodal5. Acts maternally as a transcriptional repressor of nodal5 and nodal6 to restrict their expression to the vegetal hemisphere of early embryos and thus establish germ layer formation. Acts at multiple points to inhibit nodal signaling, repressing the expression of the other mesoderm-inducing nodal genes nodal, nodal2 and nodal4, and also acting downstream to induce expression of genes including trim33/ectodermin, ema and coco, whose products repress nodal signaling (By similarity).
messages: Was originally termed sox-11.

8355:hoxb7.L
gene id: 8355:hoxb7.L
uniprot id: A0A974BX52
uniprot id: Q4QR28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

8355:LOC108708797
gene id: 8355:LOC108708797
uniprot id: A0A8J1MAT1
names: Caution
names: Cofactor
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:rnf8.S
gene id: 8355:rnf8.S
uniprot id: A0A974HGY6
uniprot id: Q7ZX20
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CHFR family.
messages: Belongs to the RNF8 family.
messages: E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites.
messages: E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated mdc1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of tp53bp1 and brca1 ionizing radiation-induced foci (IRIF). H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains, leading to degradation of substrate proteins. In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation.
messages: Homodimer.
messages: Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the rnf8 homodimer and a E2 heterodimer of ube2n and ube2v2.
messages: Nucleus
messages: The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1.

8355:LOC121394769
gene id: 8355:LOC121394769
uniprot id: A0A8J1L0U6
uniprot id: A0A8J1L225
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: nucleoplasm

8355:coq8b.L
gene id: 8355:coq8b.L
uniprot id: Q6AX14
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

8355:drc1.L
gene id: 8355:drc1.L
uniprot id: Q7T0Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DRC1 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.
messages: Component of the nexin-dynein regulatory complex (N-DRC).
messages: cilium axoneme
messages: flagellum axoneme

8355:LOC108714003
gene id: 8355:LOC108714003
uniprot id: A0A8J0V046
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

8355:nrf1.S
gene id: 8355:nrf1.S
uniprot id: A0A8J0UY16
uniprot id: Q6DDH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRF1/Ewg family.
messages: Nucleus

8355:cdk15.L
gene id: 8355:cdk15.L
uniprot id: A0A1L8EWW8
uniprot id: A0A8J0TV46
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:smpd4.L
gene id: 8355:smpd4.L
uniprot id: Q5XHG1
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, and endoplasmic reticulum organization and function. May sensitize cells to DNA damage-induced apoptosis.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Nucleus envelope
messages: sarcolemma

8355:sctr.S
gene id: 8355:sctr.S
uniprot id: A0A1L8ENG6
uniprot id: A0A8J1LZ43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

8355:limch1.L
gene id: 8355:limch1.L
uniprot id: Q3KQW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Actin stress fibers-associated protein that activates non-muscle myosin IIa. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration.
messages: Belongs to the LIMCH1 family.
messages: stress fiber

8355:LOC121398266
gene id: 8355:LOC121398266
uniprot id: A0A8J1LVT1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:acp4.S
gene id: 8355:acp4.S
uniprot id: Q3KQG9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histidine acid phosphatase family.
messages: Homodimer.
messages: Membrane

8355:rab3gap1.L
gene id: 8355:rab3gap1.L
uniprot id: A0A8J1LR96
uniprot id: Q642R9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rab3-GAP catalytic subunit family.
messages: Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of rab3gap1 and rab3gap2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (By similarity). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (By similarity). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (By similarity). The Rab3GAP complex, acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (By similarity). Required for recruiting and activating RAB18 at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (By similarity). Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: The Rab3 GTPase-activating complex is a heterodimer composed of rab3gap1 and rab3gap2 (By similarity). The Rab3 GTPase-activating complex interacts with DMXL2 (By similarity). Interacts with LMAN1 (By similarity).

8355:plod1.S
gene id: 8355:plod1.S
uniprot id: A0A1L8FFL3
uniprot id: A0A8J0TFS6
uniprot id: A0A8J1LCC0
uniprot id: A0A8J1LCE2
uniprot id: A0A974CD07
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

8355:kif17.L
gene id: 8355:kif17.L
uniprot id: A0A310U6V8
uniprot id: A0A8J0U5D4
uniprot id: A0A974GZW2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8355:LOC108705815
gene id: 8355:LOC108705815
uniprot id: A0A8J0TZB4
uniprot id: A0A8J1MAF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:fzd6.L
gene id: 8355:fzd6.L
uniprot id: A0A1L8FZR1
uniprot id: A0A8J0VI00
uniprot id: A0A974HGV8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:tnfrsf6b.L
gene id: 8355:tnfrsf6b.L
uniprot id: A0A1L8ET70
uniprot id: A0A974BXC2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:stc2.S
gene id: 8355:stc2.S
uniprot id: A0A1L8GV38
uniprot id: A0A974D9G5
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

8355:cers5.S
gene id: 8355:cers5.S
uniprot id: A0A8J1MCR7
uniprot id: Q5U4L5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

8355:lgmn.S
gene id: 8355:lgmn.S
uniprot id: A0A1L8F0I1
uniprot id: A0A974C388
names: Similarity
messages: Belongs to the peptidase C13 family.

8355:b3gat1.L
gene id: 8355:b3gat1.L
uniprot id: A0A1L8FKZ1
uniprot id: A0A8J1L819
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:rnf114.L
gene id: 8355:rnf114.L
uniprot id: A0A974H2V4
uniprot id: Q5M9A8
names: Subunit
messages: Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.

8355:XB986526.L
gene id: 8355:XB986526.L
uniprot id: A0A1L8HDQ7
uniprot id: A0A8J1M7T7
uniprot id: A0A8J1M7Z2
uniprot id: A0A974HXM7
names: Similarity
messages: Belongs to the 3-beta-HSD family.

8355:fut8.S
gene id: 8355:fut8.S
uniprot id: A0A8J1LL44
uniprot id: A0JMS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 23 family.
messages: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
messages: Golgi stack membrane
messages: Membrane

8355:pabpc1l.S
gene id: 8355:pabpc1l.S
uniprot id: A0A8J1LVR8
uniprot id: A0A8J1LVU3
uniprot id: A0A8J1LW82
uniprot id: A0A8J1LX47
uniprot id: A0A8J1LXZ9
uniprot id: Q98SP8
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds and protects the poly(A) tail of mRNA with or without an AU-rich element (ARE) and prevents mRNA deadenylation. Stimulates the translation of mRNAs to which it is bound during early development.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm
messages: Expressed in adult testis, but at a reduced level compared to oocytes.
messages: Interacts with dazl in an RNA-independent manner. The C-terminus can self-associate and also interact with the C-terminus of pabpc1, independently of RNA. RRM 1 and RRM 2 interact with both eif4g1 and paip1, and the C-terminus also interacts with paip1. Prior to oocyte maturation, found in a complex with dazl and pum2 proteins and spdy1 mRNA; pum2 dissociates from the complex during maturation. Interacts with the translation termination factor sup35/erf3.
messages: Predominant from the stage VI oocyte through to the neurula stage (30 hours embryo), with levels decreasing at the onset of zygotic transcription.

8355:cyp26b1.S
gene id: 8355:cyp26b1.S
uniprot id: A0A1L8HKG6
uniprot id: A0A974DSV1
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:rab9a.S
gene id: 8355:rab9a.S
uniprot id: A0A974DKL0
uniprot id: Q6GQ88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: phagosome membrane

8355:ccl4.L
gene id: 8355:ccl4.L
uniprot id: A0A1L8HG64
uniprot id: A0A974DN70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

8355:rdh7.2.L
gene id: 8355:rdh7.2.L
uniprot id: Q63ZL6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8355:gpt2.L
gene id: 8355:gpt2.L
uniprot id: A0A1L8GLA9
uniprot id: A0A974HNQ4
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

8355:pappa2.S
gene id: 8355:pappa2.S
uniprot id: A0A8J1KJD1
names: Caution
names: Similarity
messages: Belongs to the peptidase M43B family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:nsun7.S
gene id: 8355:nsun7.S
uniprot id: A0A1L8HL15
uniprot id: A0A974DRI9
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:hba1.S
gene id: 8355:hba1.S
uniprot id: A0A974H1K9
uniprot id: Q6DJI3
names: Similarity
messages: Belongs to the globin family.

8355:cyp7a1.L
gene id: 8355:cyp7a1.L
uniprot id: A0A1L8FZ27
uniprot id: A0A974CR22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

8355:LOC108696872
gene id: 8355:LOC108696872
uniprot id: A0A1L8FPE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane

8355:LOC108716985
gene id: 8355:LOC108716985
uniprot id: A0A1L8GAC7
uniprot id: A0A8J0V8M8
uniprot id: A0A8J0V8N2
uniprot id: A0A8J0V8N7
uniprot id: A0A8J0VBL2
uniprot id: A0A8J0VBL7
uniprot id: A0A8J0VC47
uniprot id: A0A8J0VC52
uniprot id: A0A8J0VCX2
uniprot id: A0A8J0VH68
uniprot id: A0A8J1KPF5
uniprot id: A0A8J1KPG1
uniprot id: A0A8J1KPG6
uniprot id: A0A8J1KPG7
uniprot id: A0A8J1KPH0
uniprot id: A0A8J1KPH2
uniprot id: A0A8J1KPH5
uniprot id: A0A8J1KPH7
uniprot id: A0A8J1KPI0
uniprot id: A0A8J1KR34
uniprot id: A0A8J1KR38
uniprot id: A0A8J1KR43
uniprot id: A0A8J1KR48
uniprot id: A0A8J1KSL1
uniprot id: A0A8J1KSL5
uniprot id: A0A8J1KSL9
uniprot id: A0A8J1KSM5
uniprot id: A0A8J1KSN6
uniprot id: A0A974HKD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Membrane

8355:LOC121393789
gene id: 8355:LOC121393789
uniprot id: A0A1L8GA76
names: Subcellular Location Annotation
messages: Cytoplasmic ribonucleoprotein granule

8355:LOC414455
gene id: 8355:LOC414455
uniprot id: A0A1L8GFG5
uniprot id: A0A8J0V5Y4
uniprot id: A0A974D082
names: Similarity
messages: Belongs to the phosphohexose mutase family.

8355:alox5.S
gene id: 8355:alox5.S
uniprot id: A0A8J1LEC2
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:sfpq.S
gene id: 8355:sfpq.S
uniprot id: A0A1L8H7P1
uniprot id: A0A8J1MEW0
uniprot id: A0A8J1MFS2
uniprot id: A0A974DIL1
names: Subcellular Location Annotation
messages: Nucleus speckle

8355:LOC108705540
gene id: 8355:LOC108705540
uniprot id: A0A8J1M4G9
uniprot id: A0A8J1M4H2
uniprot id: A0A8J1M4H6
uniprot id: A0A8J1M4H7
uniprot id: A0A8J1M4I0
uniprot id: A0A8J1M4I1
uniprot id: A0A8J1M4I2
uniprot id: A0A8J1M5K4
uniprot id: A0A8J1M5K8
uniprot id: A0A8J1M5L3
uniprot id: A0A8J1M6A4
uniprot id: A0A8J1M6A9
uniprot id: A0A8J1M6B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Nucleus

8355:letm2.S
gene id: 8355:letm2.S
uniprot id: A0A1L8GRP0
uniprot id: A0A974D8V3
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane

8355:tmem47.S
gene id: 8355:tmem47.S
uniprot id: A0A1L8H8I2
uniprot id: A0A974DI27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

8355:uts2b.S
gene id: 8355:uts2b.S
uniprot id: A0A310U4Z8
uniprot id: A0A974BR52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

8355:lsm2.S
gene id: 8355:lsm2.S
uniprot id: Q52KE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: Nucleus

8355:slc22a15.1.L
gene id: 8355:slc22a15.1.L
uniprot id: Q6NUB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Membrane
messages: Probably transports organic cations.

8355:mcl1.L
gene id: 8355:mcl1.L
uniprot id: B6V6J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: nucleoplasm

8355:LOC121401273
gene id: 8355:LOC121401273
uniprot id: A0A1L8H2B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108718638
gene id: 8355:LOC108718638
uniprot id: A0A8J1KW62
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108701370
gene id: 8355:LOC108701370
uniprot id: A0A1L8EWE8
uniprot id: A0A974BZ33
names: Subcellular Location Annotation
messages: Nucleus

8355:mapk8ip3.S
gene id: 8355:mapk8ip3.S
uniprot id: A0A8J1LYB8
names: Similarity
messages: Belongs to the JIP scaffold family.

8355:slc32a1.S
gene id: 8355:slc32a1.S
uniprot id: Q6PF45
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient (By similarity). May also transport beta-alanine (By similarity). Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake (By similarity).
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Cytoplasmic vesicle membrane
messages: Initially expressed in late neurula stages in the anterior spinal cord. By early tailbud stages, expression extends posteriorly along the entire developing spinal cord and appears in the hindbrain. In late tailbud embryos, expressed in the forebrain, midbrain, hindbrain, spinal cord and retina. In swimming tadpoles, expressed in an extended and more intense pattern including interneurons.
messages: Juge et al. shows that SLC32A1 is a symporter of both 4-aminobutanoate or glycine or beta-alanine with Cl(-) that operates according an electrical gradient without the need for a chemical gradient (By similarity). However Farsi et al. and Egashira et al. confirm that SLC32A1 is an antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or glycine and exclude any coupling with chloride (By similarity).
messages: Presynapse

8355:mtmr10.S
gene id: 8355:mtmr10.S
uniprot id: Q5U581
names: Caution
names: Similarity
messages: Although it belongs to the non-receptor class myotubularin subfamily, lacks the conserved active site cysteine residue at position 391 in the dsPTPase catalytic loop, suggesting that it has no phosphatase activity.
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

8355:ston1.S
gene id: 8355:ston1.S
uniprot id: A0A1L8G1D4
uniprot id: A0A974CRS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Stoned B family.
messages: Cytoplasm

8355:gpr21.L
gene id: 8355:gpr21.L
uniprot id: A0A1L8F6D2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:utp15.L
gene id: 8355:utp15.L
uniprot id: A0A974E2Z9
uniprot id: Q7ZXZ2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. May be a component of the proposed t-UTP subcomplex of the ribosomal small subunit (SSU) processome.
messages: Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: nucleolus

8355:ndufs8.L
gene id: 8355:ndufs8.L
uniprot id: Q66KT2
names: Similarity
messages: Belongs to the complex I 23 kDa subunit family.

8355:opn5.L
gene id: 8355:opn5.L
uniprot id: A0A974HKU3
uniprot id: E0R7P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8355:LOC121399879
gene id: 8355:LOC121399879
uniprot id: A0A8J1M7P6
uniprot id: A0A8J1M7U2
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:osbpl11.S
gene id: 8355:osbpl11.S
uniprot id: A0A1L8ENK3
uniprot id: A0A8J0U074
uniprot id: A0A974BUJ2
names: Similarity
messages: Belongs to the OSBP family.

8355:map3k12.L
gene id: 8355:map3k12.L
uniprot id: A0A1L8HIG9
uniprot id: A0A974DPW1
uniprot id: A7J1T3
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

8355:gbx2.1.L
gene id: 8355:gbx2.1.L
uniprot id: A0A974H3Q9
uniprot id: A6H8J9
names: Subcellular Location Annotation
messages: Nucleus

8355:tubb4b.S
gene id: 8355:tubb4b.S
uniprot id: A0A8J1LK88
uniprot id: A0A974H5F1
uniprot id: Q7ZY50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

8355:mettl16.L
gene id: 8355:mettl16.L
uniprot id: A0A974HXW5
uniprot id: Q6GR37
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. METTL16/RlmF family.
messages: Cytoplasm
messages: Methyltransferase activity is autoinhibited by the K-loop region that blocks S-adenosyl-L-methionine-binding. Upon activation, K-loop changes conformation, allowing S-adenosyl-L-methionine-binding and subsequent methyltransferase activity. mRNA N6-adenosine-methyltransferase activity is inhibited by zinc.
messages: Nucleus
messages: RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure.
messages: RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, impairing MAT2A splicing and protein expression. In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A. In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs.
messages: The K-loop region occludes the S-adenosyl-L-methionine-binding pocket. Upon activation, conformation of the K-loop changes, allowing S-adenosyl-L-methionine-binding.
messages: The VCR (vertebrate conserved) regions bind the first hairpin of MAT2A mRNAs. The VCR regions interact with the internal stem-loop within U6 snRNAs, inducing the conformational rearrangement of the A43-containing region of U6 snRNA, thereby modifying the RNA structure to become suitable for productive catalysis by the methyltransferase region.

8355:plrg1.S
gene id: 8355:plrg1.S
uniprot id: A0A1L8HLS8
uniprot id: A0A974I0T6
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

8355:LOC108699089
gene id: 8355:LOC108699089
uniprot id: A0A1L8FBZ7
uniprot id: A0A974CAN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC121399872
gene id: 8355:LOC121399872
uniprot id: A0A1L8HDA9
names: Subcellular Location Annotation
messages: Nucleus

8355:serpinf1.L
gene id: 8355:serpinf1.L
uniprot id: A0A974HXQ8
uniprot id: Q6GN71
names: Similarity
messages: Belongs to the serpin family.

8355:emc8.L
gene id: 8355:emc8.L
uniprot id: A0A1L8GKZ9
uniprot id: A0A974D2V8
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

8355:sgk3.L
gene id: 8355:sgk3.L
uniprot id: A0A1L8FZ68
uniprot id: A0A974HGB5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

8355:dck.2.L
gene id: 8355:dck.2.L
uniprot id: Q6DD33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DCK/DGK family.
messages: Homodimer.
messages: Nucleus
messages: Phosphorylates the deoxyribonucleosides deoxyadenosine, deoxycytidine and deoxyguanosine with highest activity against deoxyguanosine followed by deadenosine and then deoxycytidine (PubMed:27906638). Shows only very minor activity against deoxyuridine and deoxythymidine (PubMed:27906638).

8355:LOC108716495
gene id: 8355:LOC108716495
uniprot id: A0A8J0V6I6
names: Similarity
messages: Belongs to the peptidase C2 family.

8355:bche.S
gene id: 8355:bche.S
uniprot id: A0A8J1KU48
uniprot id: A0A8J1KU51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Secreted

8355:LOC108710677
gene id: 8355:LOC108710677
uniprot id: A0A1L8H4F8
uniprot id: A0A974DI63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:dctn2.S
gene id: 8355:dctn2.S
uniprot id: A0A974DLC3
uniprot id: Q6IRB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dynactin subunit 2 family.
messages: Membrane
messages: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes (By similarity).
messages: Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3.
messages: centrosome
messages: cytoskeleton

8355:ppfia1.L
gene id: 8355:ppfia1.L
uniprot id: A0A1L8GIV1
uniprot id: A0A8J1MV73
uniprot id: A0A8J1MV80
uniprot id: A0A8J1MVG7
uniprot id: A0A8J1MVH1
uniprot id: A0A8J1MVH7
uniprot id: A0A8J1MWC9
uniprot id: A0A8J1MWD3
uniprot id: A0A8J1MWR4
uniprot id: A0A8J1MWS0
uniprot id: A0A8J1MXN6
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

8355:LOC108719808
gene id: 8355:LOC108719808
uniprot id: A0A1L8FQG9
uniprot id: A0A974CJJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

8355:ppm1f.S
gene id: 8355:ppm1f.S
uniprot id: A0A8J0UCS3
uniprot id: A0A8J1M3G1
names: Similarity
messages: Belongs to the PP2C family.

8355:kcnk6.S
gene id: 8355:kcnk6.S
uniprot id: A0A974C4G0
uniprot id: Q0IHD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Endosome
messages: Membrane
messages: Perikaryon
messages: Recycling endosome
messages: Synaptic cell membrane
messages: Vesicle
messages: dendrite

8355:ints10.L
gene id: 8355:ints10.L
uniprot id: A0A1L8HWD7
uniprot id: A0A8J0UTD2
uniprot id: A0A8J0UUH0
uniprot id: A0A8J1KKF4
uniprot id: A0A974DZM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 10 family.
messages: Nucleus

8355:gata1.L
gene id: 8355:gata1.L
uniprot id: P23767
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in the developing ventral blood island, and in both tadpole and adult erythrocytes.
messages: Expressed zygotically by embryonic stage 11 (mid-gastrula).
messages: Nucleus
messages: Transcription factor that acts synergistically with tal1/scl and lmo2 to specify embryonic dorsal mesoderm to a hematopoietic fate.

8355:LOC121394460
gene id: 8355:LOC121394460
uniprot id: A0A8J1KZ62
names: Similarity
messages: Belongs to the helicase family.

8355:LOC495407
gene id: 8355:LOC495407
uniprot id: Q5U4Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane
messages: Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate.

8355:mpv17l2.L
gene id: 8355:mpv17l2.L
uniprot id: A0A1L8HWU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

8355:LOC108713875
gene id: 8355:LOC108713875
uniprot id: A0A1L8GJH1
uniprot id: A0A974D3T0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

8355:pou3f3.S
gene id: 8355:pou3f3.S
uniprot id: A0A1L8H8P3
uniprot id: A0A974HW94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus

8355:trpt1.L
gene id: 8355:trpt1.L
uniprot id: A0A1L8GJQ3
uniprot id: A0A974HNI0
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.

8355:slc9a4.L
gene id: 8355:slc9a4.L
uniprot id: A0A1L8HGQ9
uniprot id: A0A974HYL4
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

8355:LOC108717743
gene id: 8355:LOC108717743
uniprot id: A0A8J0VBP5
uniprot id: A0A8J0VK83
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

8355:rpl37.L
gene id: 8355:rpl37.L
uniprot id: A0A1L8I2F1
uniprot id: A0A974I5A2
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

8355:trnt1.S
gene id: 8355:trnt1.S
uniprot id: Q8AXB8
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

8355:rnf128.L
gene id: 8355:rnf128.L
uniprot id: Q8AWW4
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Auto-ubiquitinated.
messages: E3 ubiquitin-protein ligase that catalyzes polyubiquitin chains (By similarity). Converts epidermis into cement gland and neural tissue in whole embryos.
messages: Endomembrane system
messages: Expressed in the cement gland, cranial placodes, and the pronephros.
messages: Present as a maternal transcript. Early expression is confined to tissues of ectodermal origin. At stage 16, the predominant area of expression is within the developing cement gland. At stage 27, expression is detected in the anterodorsal lateral line placode, the olfactory placode, and the otic vesicle and pronephros.
messages: perinuclear region

8355:LOC108704302
gene id: 8355:LOC108704302
uniprot id: A0A8J1LZU9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:podxl2.S
gene id: 8355:podxl2.S
uniprot id: A0A1L8GHP0
uniprot id: A0A974D0G6
names: Subcellular Location Annotation
messages: Membrane

8355:ybx2.L
gene id: 8355:ybx2.L
uniprot id: P21574
names: Caution
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed maternally.
messages: Has a dual function in oocytes: as a DNA-binding protein, binds to the Y-box sequence (CTGATTGGCCAA) in the promoters of target genes to stimulate transcription. May also function at CCAAT-containing promoters that lack the consensus Y-box sequence. Also binds mRNA to promote accumulation of the transcripts it contributes to produce.
messages: In adults, expression is restricted to the ovary and testis.
messages: Phosphorylation activates in vitro RNA binding.
messages: Possibly forms a heterodimer with p54 in the 6S and 15S mRNA-binding particles. The principle component of multiple messenger ribonucleoprotein (mRNP) complexes. Component of a ribonucleoprotein (RNP) complex, composed at least of elavl1/elrA and/or elavl2/elrB, igf2bp3/vg1RBP, ddx6/Xp54, ybx2/frgy2, lsm14b/rap55b and, in a subset of RNP complexes, stau1/staufen. Component of a ribonucleoprotein (RNP) complex, at least composed of lsm14a/rap55a, ybx2/frgy2, ddx6/Xp54 and eif4enif1/4E-T. Does not appear to directly bind lsm14a/rap55a. Component of a ribonucleoprotein (RNP) complex, at least composed of cpeb1, lsm14b/rap55b, ddx6/Xp54, ybx2/frgy2, pat1/P100, eif4enif1/4E-T and eif4e1b. Interaction with cpeb1 is RNA-dependent.
messages: PubMed:2247479 report a decline in expression during oogenesis, but PubMed:1729676 show expression is maintained at a high level throughout oogenesis.

8355:LOC108708295
gene id: 8355:LOC108708295
uniprot id: A0A1L8HFY2
uniprot id: A0A974DN37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

8355:epha4.L
gene id: 8355:epha4.L
uniprot id: A0A8J0V933
uniprot id: A0A8J0VD80
uniprot id: A0A8J1KMP3
uniprot id: A0A974CY95
uniprot id: Q7ZYM7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Membrane

8355:prickle2.L
gene id: 8355:prickle2.L
uniprot id: A0A1L8GQ36
uniprot id: A0A8J0V3T3
uniprot id: A0A974D884
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prickle / espinas / testin family.
messages: Cell membrane
messages: Membrane

8355:LOC108719663
gene id: 8355:LOC108719663
uniprot id: A0A1L8HVF1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8355:rabggtb.S
gene id: 8355:rabggtb.S
uniprot id: Q5EAU8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

8355:gcg2
gene id: 8355:gcg2
uniprot id: A0A1L8EP35
uniprot id: A0A8J1LWW9
uniprot id: A0A974BUM4
uniprot id: O42144
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.
messages: Secreted

8355:sntg2.S
gene id: 8355:sntg2.S
uniprot id: A0A8J1KUG4
uniprot id: A0A8J1KW17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: cytoskeleton

8355:lhfpl2.L
gene id: 8355:lhfpl2.L
uniprot id: A0A1L8I2U6
uniprot id: A0A974E397
names: Subcellular Location Annotation
messages: Membrane

8355:slc4a1.S
gene id: 8355:slc4a1.S
uniprot id: A0A8J0TRK4
uniprot id: A0A8J0TYW1
uniprot id: A0A8J0U1U8
uniprot id: A0A8J1LXS0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:LOC108703939
gene id: 8355:LOC108703939
uniprot id: A0A8J0U475
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inflammasome

8355:prep.L
gene id: 8355:prep.L
uniprot id: Q4KLX3
names: Similarity
messages: Belongs to the peptidase S9A family.

8355:LOC108697171
gene id: 8355:LOC108697171
uniprot id: A0A1L8FE31
uniprot id: A0A8J1LBC7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

8355:atp6v1c1.L
gene id: 8355:atp6v1c1.L
uniprot id: A0A974CP53
uniprot id: Q5XH14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity).
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

8355:dlx6.L
gene id: 8355:dlx6.L
uniprot id: A0A8J0VMQ9
uniprot id: A0A974CMC2
uniprot id: Q0P3Q7
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108707797
gene id: 8355:LOC108707797
uniprot id: A0A8J1M6K0
uniprot id: A0A8J1M7M6
uniprot id: A0A8J1M8F7
names: Similarity
messages: Belongs to the CFAP91 family.

8355:strip2.L
gene id: 8355:strip2.L
uniprot id: A0A8J0UJC7
names: Similarity
messages: Belongs to the STRIP family.

8355:jakmip1.L
gene id: 8355:jakmip1.L
uniprot id: A0A8J0U366
uniprot id: A0A8J1M1V2
uniprot id: A0A8J1M1W4
uniprot id: A0A8J1M1Z9
uniprot id: A0A8J1M342
uniprot id: A0A8J1M3U8
uniprot id: Q6INS9
names: Similarity
messages: Belongs to the JAKMIP family.

8355:MGC80748
gene id: 8355:MGC80748
uniprot id: A0A8J0TWT5
uniprot id: A0A974I1R6
uniprot id: Q6GP13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

8355:mtmr10.L
gene id: 8355:mtmr10.L
uniprot id: Q6NU08
names: Caution
names: Similarity
messages: Although it belongs to the non-receptor class myotubularin subfamily, lacks the conserved active site cysteine residue at position 390 in the dsPTPase catalytic loop, suggesting that it has no phosphatase activity.
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

8355:casp8.L
gene id: 8355:casp8.L
uniprot id: Q9IB64
names: Similarity
messages: Belongs to the peptidase C14A family.

8355:recql.L
gene id: 8355:recql.L
uniprot id: Q32NN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

8355:LOC121393275
gene id: 8355:LOC121393275
uniprot id: A0A8J1KIJ8
uniprot id: A0A8J1KIJ9
uniprot id: A0A8J1KKA1
uniprot id: A0A8J1KLP1
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:arpc2.L
gene id: 8355:arpc2.L
uniprot id: A0A8J0TK15
uniprot id: Q0IH88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:17178911). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:17178911). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).
messages: Belongs to the ARPC2 family.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of actr2/arp2, actr3/arp3, arpc1 (arpc1a or arpc1b), arpc2, arpc3, arpc4 and arpc5.
messages: Component of the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: Nucleus
messages: cytoskeleton

8355:LOC108717591
gene id: 8355:LOC108717591
uniprot id: A0A1L8G4U1
uniprot id: A0A974CUP8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:trappc6a.L
gene id: 8355:trappc6a.L
uniprot id: A0A974C7B3
uniprot id: Q7ZXX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

8355:kcnj3.S
gene id: 8355:kcnj3.S
uniprot id: A0A1L8EP07
uniprot id: A0A974BU82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

8355:LOC108717416
gene id: 8355:LOC108717416
uniprot id: A0A8J1KT03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: Membrane
messages: Vacuole membrane

8355:LOC108717032
gene id: 8355:LOC108717032
uniprot id: A0A1L8GAR4
uniprot id: A0A974CYH9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:tph1.L
gene id: 8355:tph1.L
uniprot id: Q92142
names: Function
names: Similarity
names: Subunit
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
messages: Homotetramer.
messages: Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis.

8355:rps24.L
gene id: 8355:rps24.L
uniprot id: A0A8J1L411
uniprot id: A0A8J1L418
uniprot id: A0A8J1L5T4
uniprot id: A0A8J1L5U7
uniprot id: P02377
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS24 family.
messages: Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: Cytoplasm
messages: nucleolus

8355:armc8.S
gene id: 8355:armc8.S
uniprot id: Q6IR87
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:LOC108702807
gene id: 8355:LOC108702807
uniprot id: A0A8J1LX01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

8355:nck1.L
gene id: 8355:nck1.L
uniprot id: A0A974CYK8
uniprot id: P79956
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

8355:pdzk1ip1.S
gene id: 8355:pdzk1ip1.S
uniprot id: A0A974D0B9
uniprot id: Q6XQ84
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: By retinoic acid.
messages: Essential for pronephric tubule development, acting upstream of pax8 and lhx1/lim1 and downstream of retinoic acid signaling to induce pronephric mesoderm to form pronephric tubule-specific cells.
messages: Expressed in prospective pronephric mesoderm at the late gastrula stage. After neurulation, expressed in the intermediate mesoderm, eye placode and blood islands. Expression becomes restricted to the pronephric proximal tubule during embryogenesis, but is absent from the connecting tubules.
messages: Expressed zygotically from late gastrula stages, persisting throughout embryogenesis with highest expression between stages 30 and 35.
messages: Membrane

8355:LOC108708350
gene id: 8355:LOC108708350
uniprot id: A0A8J0UE84
uniprot id: A0A8J0UFH9
uniprot id: A0A8J0UFR0
uniprot id: A0A8J0UI66
uniprot id: A0A8J0UI72
names: Subcellular Location Annotation
messages: Nucleus

8355:gpr132.S
gene id: 8355:gpr132.S
uniprot id: A0A1L8F017
uniprot id: A0A974C1M7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:LOC108697235
gene id: 8355:LOC108697235
uniprot id: A0A8J1LC67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane

8355:susd6.S
gene id: 8355:susd6.S
uniprot id: A0A8J1LLK5
uniprot id: Q7ZXH8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108705161
gene id: 8355:LOC108705161
uniprot id: A0A8J0TYF6
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:ndufa1.L
gene id: 8355:ndufa1.L
uniprot id: A0A1L8F7N1
uniprot id: A0A974C7Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA1 subunit family.
messages: Mitochondrion inner membrane

8355:spire2.S
gene id: 8355:spire2.S
uniprot id: A0A1L8GEZ6
uniprot id: A0A8J0V6R2
uniprot id: A0A974HLE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spire family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytoskeleton

8355:thrsp.L
gene id: 8355:thrsp.L
uniprot id: A0A1L8F7H8
uniprot id: A0A974C6X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

8355:LOC108697977
gene id: 8355:LOC108697977
uniprot id: A0A1L8FGM0
uniprot id: A0A974CCQ2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

8355:slc9a3r2.L
gene id: 8355:slc9a3r2.L
uniprot id: A0A8J1LUV4
names: Subcellular Location Annotation
messages: Endomembrane system

8355:dtna.L
gene id: 8355:dtna.L
uniprot id: A0A8J0VE55
uniprot id: A0A8J0VGX3
uniprot id: A0A8J0VI52
uniprot id: A0A8J1KV28
uniprot id: A0A8J1KV33
uniprot id: A0A8J1KV35
uniprot id: A0A8J1KV37
uniprot id: A0A8J1KV39
uniprot id: A0A8J1KV46
uniprot id: A0A8J1KWL9
uniprot id: A0A8J1KWM4
uniprot id: A0A8J1KY33
uniprot id: Q7ZX13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

8355:gfra2.L
gene id: 8355:gfra2.L
uniprot id: A0A8J1MPH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane

8355:cpb1.S
gene id: 8355:cpb1.S
uniprot id: Q5U552
names: Similarity
messages: Belongs to the peptidase M14 family.

8355:atp2a2.S
gene id: 8355:atp2a2.S
uniprot id: A0A8J1LRS3
uniprot id: A0A974I1Y9
uniprot id: A2RV57
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

8355:ncaph2.S
gene id: 8355:ncaph2.S
uniprot id: A0A8J1MTK6
names: Similarity
messages: Belongs to the CND2 H2 (condensin-2 subunit 2) family.

8355:ube3a.L
gene id: 8355:ube3a.L
uniprot id: A0A1L8HGV0
uniprot id: A0A974DNL3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.
messages: Nucleus

8355:LOC108712848
gene id: 8355:LOC108712848
uniprot id: A0A1L8GSK3
uniprot id: A0A974D9T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

8355:hmbs.2.S
gene id: 8355:hmbs.2.S
uniprot id: A0A8J0U5M5
uniprot id: Q5XH11
names: Similarity
messages: Belongs to the HMBS family.

8355:ccz1b.L
gene id: 8355:ccz1b.L
uniprot id: A0A1L8EY01
uniprot id: A0A974C0G6
names: Similarity
messages: Belongs to the CCZ1 family.

8355:cdc42se2l.S
gene id: 8355:cdc42se2l.S
uniprot id: A0A1L8HPI8
uniprot id: A0A974DW62
uniprot id: Q5FVD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly.
messages: cytoskeleton

8355:LOC108700328
gene id: 8355:LOC108700328
uniprot id: A0A8J0TRG1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:atat1.S
gene id: 8355:atat1.S
uniprot id: Q5FWM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase ATAT1 family.
messages: Cytoplasm
messages: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. May be involved in neuron development.
messages: axon
messages: clathrin-coated pit
messages: cytoskeleton
messages: focal adhesion
messages: spindle

8355:LOC108714191
gene id: 8355:LOC108714191
uniprot id: A0A1L8GLP7
uniprot id: A0A8J1MWM5
uniprot id: A0A974HNT5
names: Similarity
messages: Belongs to the GIPC family.

8355:LOC108704373
gene id: 8355:LOC108704373
uniprot id: A0A8J0U4E4
uniprot id: A0A8J0U778
names: Similarity
messages: Belongs to the ARTD/PARP family.

8355:abcg5.S
gene id: 8355:abcg5.S
uniprot id: A0A1L8G1F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

8355:ppard.S
gene id: 8355:ppard.S
uniprot id: A0A8J1MB60
uniprot id: P37233
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: 'Lys-48'-linked polyubiquitinated; leading to proteasomal degradation. Deubiquitinated and stabilized by OTUD3.
messages: Belongs to the nuclear hormone receptor family.
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Heterodimer with the retinoid X receptor.
messages: Ligand-activated transcription factor key mediator of energy metabolism in adipose tissues. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
messages: Nucleus
messages: Oocytes, embryos, and adults.
messages: Ubiquitous.

8355:ikbkb.L
gene id: 8355:ikbkb.L
uniprot id: Q6INT1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:LOC108700977
gene id: 8355:LOC108700977
uniprot id: A0A8J0TUG6
uniprot id: A0A8J1LTM6
names: Similarity
messages: Belongs to the CENP-X/MHF2 family.

8355:ncaph2.L
gene id: 8355:ncaph2.L
uniprot id: Q641G4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CND2 H2 (condensin-2 subunit 2) family.
messages: Component of the condensin-2 complex, which contains the smc2 and smc4 heterodimer, and three non SMC subunits, ncapg2, ncaph2 and ncapd3 that probably regulate the complex.
messages: Nucleus
messages: Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture.

8355:slc6a14.2.L
gene id: 8355:slc6a14.2.L
uniprot id: Q6NTW9
names: Subcellular Location Annotation
messages: Membrane

8355:timm8b.S
gene id: 8355:timm8b.S
uniprot id: A1A639
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

8355:LOC108706206
gene id: 8355:LOC108706206
uniprot id: A0A8J0UA51
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:LOC108707421
gene id: 8355:LOC108707421
uniprot id: A0A8J1M851
uniprot id: A0A8J1M8Y3
names: Similarity
messages: Belongs to the EVA1 family.

8355:cul9.L
gene id: 8355:cul9.L
uniprot id: A0A8J0V9T8
uniprot id: A0A8J0VB52
uniprot id: A0A8J1KMK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cullin family.
messages: Cytoplasm

8355:LOC108719932
gene id: 8355:LOC108719932
uniprot id: A0A1L8FR88
uniprot id: A0A8J0VMU6
uniprot id: A0A974CJN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

8355:LOC108715553
gene id: 8355:LOC108715553
uniprot id: A0A8J1KU25
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:vps4b.L
gene id: 8355:vps4b.L
uniprot id: A0A1L8FXP4
uniprot id: A0A974HFR2
uniprot id: Q6DJK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

8355:LOC108719104
gene id: 8355:LOC108719104
uniprot id: A0A1L8FXP6
uniprot id: A0A974CNJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

8355:nipbl.L
gene id: 8355:nipbl.L
uniprot id: A0A1L8I2N9
uniprot id: A0A8J0UI22
uniprot id: A0A974E2G6
uniprot id: Q1XG42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC2/Nipped-B family.
messages: Nucleus

8355:arf6.2.S
gene id: 8355:arf6.2.S
uniprot id: P51645
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cell membrane
messages: Cleavage furrow
messages: Endosome membrane
messages: GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. May contribute to the regulation of dendritic branching, filopodia extension and dendritic spine development (By similarity).
messages: Golgi apparatus
messages: Midbody ring
messages: Recycling endosome membrane
messages: cytosol
messages: filopodium membrane
messages: ruffle

8355:hmces.L
gene id: 8355:hmces.L
uniprot id: A0A8J0UZ11
uniprot id: A0A8J1MTM5
uniprot id: Q6IND6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SOS response-associated peptidase family.
messages: Chromosome
messages: Glu-129 is involved in sensing abasic sites in single-stranded DNA (ssDNA). His-203 stabilizes the abasic sites by forming a hydrogen bond with the O4' hydroxyl group.
messages: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction (By similarity). Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity).
messages: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction.

8355:atp13a5.L
gene id: 8355:atp13a5.L
uniprot id: A0A1L8GA40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

8355:atg4a.S
gene id: 8355:atg4a.S
uniprot id: A9JS10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

8355:lpar2.S
gene id: 8355:lpar2.S
uniprot id: A0A974GZX5
uniprot id: Q66J84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cell surface
messages: Endosome
messages: Membrane

8355:slc7a2.1.S
gene id: 8355:slc7a2.1.S
uniprot id: A0A1L8HLD4
uniprot id: A0A8J0UAR1
uniprot id: A0A8J1M166
uniprot id: A0A974DT02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

8355:nat9.L
gene id: 8355:nat9.L
uniprot id: A0A1L8EUD5
uniprot id: A0A974BY06
names: Similarity
messages: Belongs to the acetyltransferase family. GNAT subfamily.

8355:tmem59.S
gene id: 8355:tmem59.S
uniprot id: A0A8J0V4Z6
uniprot id: Q6GNB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:rc3h1.L
gene id: 8355:rc3h1.L
uniprot id: Q6NUC6
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasmic granule
messages: HEPN (higher eukaryotes and prokaryotes nucleotide-binding) are observed in both N- and C-terminal sides of ROQ domain with 3D structure even if they are poredcted on the basis of sequence.
messages: P-body
messages: Post-transcriptional repressor. May recognize and bind to the 3'-UTR of some mRNAs and promote mRNA decay.
messages: Proteolytically cleaved after Arg-509 and Arg-576 by MALT1 in activated CD4(+) T cells; cleavage at Arg-509 and Arg-576 is critical for promoting RC3H1 degradation in response to T-cell receptor (TCR) stimulation, and hence is necessary for prolonging the stability of a set of mRNAs controlling Th17 cell differentiation.
messages: The RING-type zinc finger is required for proper localization to stress granules, but not to P-bodies.
messages: The ROQ region is required for CDE RNA-binding. It may also be involved in localization to stress granules.

8355:cfap36.L
gene id: 8355:cfap36.L
uniprot id: A0A974CUK7
uniprot id: Q7T0S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP36 family.
messages: Cytoplasm
messages: Nucleus
messages: flagellum

8355:LOC121402223
gene id: 8355:LOC121402223
uniprot id: A0A8J1MSM0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:chmp2b.S
gene id: 8355:chmp2b.S
uniprot id: A0A8J0UHW9
uniprot id: A0A974HUT7
uniprot id: Q7SYR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Late endosome membrane
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity).
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome (By similarity).
messages: cytosol

8355:brd1.S
gene id: 8355:brd1.S
uniprot id: A0A1L8GU33
uniprot id: A0A8J0UR36
uniprot id: A0A8J0UXK3
uniprot id: A0A974DAQ2
names: Subcellular Location Annotation
messages: Nucleus

8355:agpat3.S
gene id: 8355:agpat3.S
uniprot id: A0A974DG90
uniprot id: Q66J57
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

8355:slc35b1.L
gene id: 8355:slc35b1.L
uniprot id: A0A8J1LQU1
uniprot id: Q6GQ70
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Probable sugar transporter.
messages: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

8355:LOC108698538
gene id: 8355:LOC108698538
uniprot id: A0A1L8F879
uniprot id: A0A974H7M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

8355:LOC108705096
gene id: 8355:LOC108705096
uniprot id: A0A8J1MYK4
uniprot id: A0A8J1MZG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

8355:LOC121398078
gene id: 8355:LOC121398078
uniprot id: A0A1L8FQ56
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:gsn.S
gene id: 8355:gsn.S
uniprot id: A0A8J0TL03
uniprot id: A0A8J0TN99
uniprot id: A0A8J0TPA8
uniprot id: A0A974C345
uniprot id: Q5XHJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
messages: cytoskeleton

8355:LOC108711733
gene id: 8355:LOC108711733
uniprot id: A0A8J1MQC5
names: Subcellular Location Annotation
messages: Secreted

8355:LOC495017
gene id: 8355:LOC495017
uniprot id: A0A974CM44
uniprot id: Q5XHF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

8355:krt78.3.L
gene id: 8355:krt78.3.L
uniprot id: A0A8J0U4M2
names: Similarity
messages: Belongs to the intermediate filament family.

8355:LOC108716793
gene id: 8355:LOC108716793
uniprot id: A0A1L8G8W7
uniprot id: A0A8J0V7U5
uniprot id: A0A8J1KRN4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8355:cmas.L
gene id: 8355:cmas.L
uniprot id: A0A1L8GVU4
uniprot id: A0A974DA13
names: Similarity
messages: Belongs to the CMP-NeuNAc synthase family.

8355:LOC108717363
gene id: 8355:LOC108717363
uniprot id: A0A8J1L617
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
messages: Vesicle
messages: secretory vesicle

8355:xrcc1.L
gene id: 8355:xrcc1.L
uniprot id: Q7ZXE5
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108714211
gene id: 8355:LOC108714211
uniprot id: A0A8J0V5X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

8355:LOC121397934
gene id: 8355:LOC121397934
uniprot id: A0A8J1LSA3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Nematocyst
messages: Target cell membrane

8355:tmem39a.S
gene id: 8355:tmem39a.S
uniprot id: A0A1L8H5I1
uniprot id: Q0IHF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

8355:abi2.L
gene id: 8355:abi2.L
uniprot id: A0A1L8EWV2
uniprot id: A0A8J0TMY4
uniprot id: A0A8J0TMY7
uniprot id: A0A8J0TVE6
uniprot id: A0A8J0TWK2
uniprot id: A0A8J0TXZ7
uniprot id: A0A8J1LUK2
uniprot id: A0A8J1LUK3
uniprot id: A0A8J1LUK7
uniprot id: A0A8J1LUK8
uniprot id: A0A8J1LV48
uniprot id: A0A8J1LV53
uniprot id: A0A8J1LW02
uniprot id: A0A8J1LWW2
uniprot id: A0A974BZN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

8355:LOC121403113
gene id: 8355:LOC121403113
uniprot id: A0A1L8GP59
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natural cytotoxicity receptor (NCR) family.
messages: Cell membrane
messages: Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6.
messages: Membrane

8355:LOC101027277
gene id: 8355:LOC101027277
uniprot id: A0A8J1MA08
uniprot id: A0A974DS17
uniprot id: G4VV18
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Membrane
messages: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.

8355:kcnj1.L
gene id: 8355:kcnj1.L
uniprot id: A0A974CGK4
uniprot id: Q6AX29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

8355:trpm7.S
gene id: 8355:trpm7.S
uniprot id: A0A1L8GSX1
uniprot id: A0A8J0UQ17
uniprot id: A0A8J0UWH1
uniprot id: A0A8J0V062
uniprot id: A0A8J1MQX5
uniprot id: A0A974HR64
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
messages: Membrane

8355:LOC108714330
gene id: 8355:LOC108714330
uniprot id: A0A8J0UX28
uniprot id: A0A8J0V1E2
uniprot id: A0A8J1MX97
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

8355:prss12.L
gene id: 8355:prss12.L
uniprot id: A0A1L8HUV0
uniprot id: A0A974DZP8
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
messages: Secreted

8355:arvcf.S
gene id: 8355:arvcf.S
uniprot id: A0A8J1M3H0
uniprot id: A0A8J1M3H1
uniprot id: A0A8J1M3H3
uniprot id: A0A8J1M3H5
uniprot id: A0A8J1M3H6
uniprot id: A0A8J1M3H8
uniprot id: A0A8J1M4M4
uniprot id: A0A8J1M4N0
names: Similarity
messages: Belongs to the beta-catenin family.

8355:LOC108705332
gene id: 8355:LOC108705332
uniprot id: A0A8J1MVI0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:adora2a.S
gene id: 8355:adora2a.S
uniprot id: A0A1L8HQB8
uniprot id: A0A974DVY4
uniprot id: Q6GM75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

8355:rpl34.S
gene id: 8355:rpl34.S
uniprot id: A0A974I312
uniprot id: Q8QFW7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

8355:tnrc6a.S
gene id: 8355:tnrc6a.S
uniprot id: A0A1L8EQS4
uniprot id: A0A8J0TTY8
uniprot id: A0A8J0U189
uniprot id: A0A8J0U2I3
uniprot id: A0A8J0U4F2
uniprot id: A0A974BW26
names: Similarity
messages: Belongs to the GW182 family.

8355:eif3d.S
gene id: 8355:eif3d.S
uniprot id: A0A974HMM5
uniprot id: Q7ZTM9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit D family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m.
messages: Cytoplasm
messages: The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

8355:zdhhc1.S
gene id: 8355:zdhhc1.S
uniprot id: A0A1L8GEB5
uniprot id: A0A974CYM1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:sike1.S
gene id: 8355:sike1.S
uniprot id: A0A1L8H692
uniprot id: A0A8J1MDL9
uniprot id: A0A974DH71
names: Similarity
messages: Belongs to the SIKE family.

8355:krt34.S
gene id: 8355:krt34.S
uniprot id: A0A8J0TY96
names: Similarity
messages: Belongs to the intermediate filament family.

8355:LOC108710411
gene id: 8355:LOC108710411
uniprot id: A0A8J0UPB3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:slc39a12.S
gene id: 8355:slc39a12.S
uniprot id: A0A1L8FQU4
uniprot id: A0A974CJC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

8355:LOC108711365
gene id: 8355:LOC108711365
uniprot id: A0A1L8H0C6
uniprot id: A0A974DF99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRINL1 family.
messages: Nucleus

8355:tspan3.S
gene id: 8355:tspan3.S
uniprot id: A0A8J1MQB6
uniprot id: A0A974DA07
uniprot id: Q5XH66
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:l3mbtl1.S
gene id: 8355:l3mbtl1.S
uniprot id: A0A1L8EMN5
uniprot id: A0A8J1LYF4
uniprot id: A0A8J1LYM5
uniprot id: A0A8J1LZN5
uniprot id: A0A8J1M0L5
names: Subcellular Location Annotation
messages: Nucleus

8355:sfrp5.S
gene id: 8355:sfrp5.S
uniprot id: Q640J3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:cisd2.L
gene id: 8355:cisd2.L
uniprot id: A0A974I342
uniprot id: Q6PCF8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CISD protein family. CISD2 subfamily.
messages: Binds 1 [2Fe-2S] cluster.
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Mitochondrion outer membrane
messages: Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy.
messages: Regulator of autophagy that contributes to antagonize becn1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of bcl2 with becn1 and is required for bcl2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy (By similarity).

8355:hnrnph1.S
gene id: 8355:hnrnph1.S
uniprot id: A0A8J0UUE0
uniprot id: A0A8J1MP13
uniprot id: A0A8J1MR61
uniprot id: A0A974D9C8
uniprot id: Q6IRC9
names: Subcellular Location Annotation
messages: nucleoplasm

8355:LOC108710683
gene id: 8355:LOC108710683
uniprot id: A0A8J0UH21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:sh3gl3.S
gene id: 8355:sh3gl3.S
uniprot id: A0A8J0UY68
uniprot id: Q5U589
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

8355:carmil1.S
gene id: 8355:carmil1.S
uniprot id: A0A8J1L2C8
uniprot id: A0A8J1L2C9
uniprot id: A0A8J1L2D0
uniprot id: A0A8J1L2D4
uniprot id: A0A8J1L3Z6
uniprot id: A0A8J1L541
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CARMIL family.
messages: Belongs to the PARI family.
messages: Cytoplasm
messages: Nucleus

8355:LOC108703253
gene id: 8355:LOC108703253
uniprot id: A0A1L8ER37
uniprot id: A0A974BVY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL family.
messages: Membrane

8355:hsf2.L
gene id: 8355:hsf2.L
uniprot id: A0A8J1KLP0
uniprot id: A0A8J1KLP7
uniprot id: A0A8J1KLR2
uniprot id: Q5EG56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

8355:mff.L
gene id: 8355:mff.L
uniprot id: A0A1L8GAZ9
uniprot id: A0A1L8GBJ2
uniprot id: A0A8J0V8Z5
uniprot id: A0A8J0V9K0
uniprot id: A0A974CX67
uniprot id: A0A974CYD8
uniprot id: Q6GQI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tango11 family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (By similarity).
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.

8355:LOC108709012
gene id: 8355:LOC108709012
uniprot id: A0A8J1MFC5
names: Subcellular Location Annotation
messages: Membrane

8355:stac3.S
gene id: 8355:stac3.S
uniprot id: A0A1L8H9W2
uniprot id: A0A974HWL6
names: Subcellular Location Annotation
messages: sarcolemma

8355:LOC108699457
gene id: 8355:LOC108699457
uniprot id: A0A1L8FCY3
uniprot id: A0A974CAD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

8355:fgf6.L
gene id: 8355:fgf6.L
uniprot id: A0A1L8GWG0
uniprot id: A0A974HRU4
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

8355:parp3.L
gene id: 8355:parp3.L
uniprot id: A0A1L8GPE0
uniprot id: A0A974D6U7
uniprot id: Q5M9A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

8355:pigh.L
gene id: 8355:pigh.L
uniprot id: A0A8J1KN13
names: Similarity
messages: Belongs to the PIGH family.

8355:LOC108710650
gene id: 8355:LOC108710650
uniprot id: A0A8J0UNE7
names: Subcellular Location Annotation
messages: Nucleus

8355:homer1.S
gene id: 8355:homer1.S
uniprot id: A0A1L8HRH3
uniprot id: A0A8J1M5X9
uniprot id: A0A974DV75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

8355:npm2.L
gene id: 8355:npm2.L
uniprot id: A0A1L8H245
uniprot id: A0A974DFF8
uniprot id: A0A974HUA0
uniprot id: Q6GQG6
names: Similarity
messages: Belongs to the nucleoplasmin family.

8355:gpc2.L
gene id: 8355:gpc2.L
uniprot id: A0A8J0ULL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

8355:f11r.L
gene id: 8355:f11r.L
uniprot id: A0A974CAK8
uniprot id: Q2VPP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily.
messages: Cell membrane
messages: Membrane
messages: tight junction

8355:clca3p.S
gene id: 8355:clca3p.S
uniprot id: A0A1L8GGD7
uniprot id: A0A974D1Z8
names: Similarity
messages: Belongs to the CLCR family.

8355:cldn6.2.L
gene id: 8355:cldn6.2.L
uniprot id: Q6NTY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8355:rps6kb1.S
gene id: 8355:rps6kb1.S
uniprot id: Q9W6Y9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

8355:gsto2.L
gene id: 8355:gsto2.L
uniprot id: A0A974HBD9
uniprot id: A8E5X8
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

8355:acsbg2.L
gene id: 8355:acsbg2.L
uniprot id: Q7ZYC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily.
messages: Catalyzes the conversion of fatty acids such as long chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids.
messages: Cytoplasm

8355:egflam.S
gene id: 8355:egflam.S
uniprot id: A0A1L8HRS5
uniprot id: A0A8J0U9U7
uniprot id: A0A8J1M492
uniprot id: A0A974I2C9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108695263
gene id: 8355:LOC108695263
uniprot id: A0A8J1L475
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GREB1 family.
messages: Membrane

8355:pnpla7.L
gene id: 8355:pnpla7.L
uniprot id: A0A8J1MMR1
uniprot id: A0A8J1MPU2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:tnfsf15.L
gene id: 8355:tnfsf15.L
uniprot id: A0A8J0THZ5
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8355:prox1.L
gene id: 8355:prox1.L
uniprot id: A0A8J1KL56
uniprot id: A0A8J1KL65
uniprot id: A0A8J1KMV9
uniprot id: A0A8J1KPA5
uniprot id: Q9DGF4
names: Subcellular Location Annotation
messages: Nucleus

8355:rnf149.L
gene id: 8355:rnf149.L
uniprot id: Q6NRX0
names: Domain
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation.
messages: Membrane
messages: The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.

8355:LOC108695933
gene id: 8355:LOC108695933
uniprot id: A0A8J0T930
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

8355:LOC121395519
gene id: 8355:LOC121395519
uniprot id: A0A1L8I2A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

8355:mtnr1c.S
gene id: 8355:mtnr1c.S
uniprot id: P49219
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for melatonin. Likely to mediate the potent effects of melatonin on pigment aggregation in melanophores. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
messages: Moderately expressed in dermal melanophores.

8355:phox2b.S
gene id: 8355:phox2b.S
uniprot id: A0A8J1LRW2
uniprot id: Q5XGX2
names: Subcellular Location Annotation
messages: Nucleus

8355:aldh1a1.L
gene id: 8355:aldh1a1.L
uniprot id: Q6DFL9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

8355:gstt1.L
gene id: 8355:gstt1.L
uniprot id: A0A974I579
uniprot id: Q6INS0
names: Similarity
messages: Belongs to the GST superfamily. Theta family.

8355:LOC108698947
gene id: 8355:LOC108698947
uniprot id: A0A8J0TCM7
names: Subcellular Location Annotation
messages: Membrane

8355:camk2b.L
gene id: 8355:camk2b.L
uniprot id: A0A1L8H1N2
uniprot id: A0A1L8H1R7
uniprot id: A0A8J0UF87
uniprot id: A0A8J0UF95
uniprot id: A0A8J0UN74
uniprot id: A0A8J0UN79
uniprot id: A0A8J0UR64
uniprot id: A0A8J0UR70
uniprot id: A0A8J1MGS5
uniprot id: A0A8J1MGS8
uniprot id: A0A8J1MGT0
uniprot id: A0A8J1MGT4
uniprot id: A0A8J1MHC0
uniprot id: A0A8J1MHC5
uniprot id: A0A8J1MHD0
uniprot id: A0A8J1MHQ6
uniprot id: A0A8J1MHR2
uniprot id: A0A8J1MIN1
uniprot id: A0A8J1MIN7
uniprot id: A0A974DDT4
uniprot id: A0A974DFJ0
uniprot id: Q6AX64
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

8355:tom1.L
gene id: 8355:tom1.L
uniprot id: A0A1L8GNT9
uniprot id: A0A974D7H6
names: Similarity
messages: Belongs to the TOM1 family.

8355:washc3.L
gene id: 8355:washc3.L
uniprot id: A0A8J1MH43
uniprot id: Q6DKA1
names: Similarity
names: Subunit
messages: Belongs to the CCDC53 family.
messages: Component of the WASH complex.

8355:rps2.L
gene id: 8355:rps2.L
uniprot id: A0A974H4Q6
uniprot id: Q7T0R9
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

8355:LOC108704260
gene id: 8355:LOC108704260
uniprot id: A0A8J0TWF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: nucleoplasm

8355:fshr.S
gene id: 8355:fshr.S
uniprot id: A0A1L8G1D8
uniprot id: A0A974CS79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
messages: Membrane

8355:pi15.S
gene id: 8355:pi15.S
uniprot id: Q3KPV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISP family.
messages: Secreted
messages: Serine protease inhibitor which displays weak inhibitory activity against trypsin (By similarity). May be involved in facial patterning during embryonic development (By similarity).

8355:LOC121399992
gene id: 8355:LOC121399992
uniprot id: A0A8J1M9M6
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:ift43.L
gene id: 8355:ift43.L
uniprot id: A0A8J0TIW1
uniprot id: Q3B8E9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis. Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base.
messages: Belongs to the IFT43 family.
messages: Component of the IFT complex A (IFT-A) complex.
messages: cilium
messages: cytoskeleton

8355:prdm8.L
gene id: 8355:prdm8.L
uniprot id: A0A1L8HW62
uniprot id: A0A8J0UMI7
names: Subcellular Location Annotation
messages: Nucleus

8355:dazap2.L
gene id: 8355:dazap2.L
uniprot id: Q8AVL1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle
messages: nuclear body

8355:LOC108712511
gene id: 8355:LOC108712511
uniprot id: A0A8J1MPQ1
uniprot id: A0A8J1MPU3
uniprot id: A0A8J1MPU8
uniprot id: A0A8J1MQQ8
uniprot id: A0A8J1MRX3
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8355:styxl2.L
gene id: 8355:styxl2.L
uniprot id: A0A8J0UC24
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

8355:LOC121394488
gene id: 8355:LOC121394488
uniprot id: A0A8J1KXX2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108700369
gene id: 8355:LOC108700369
uniprot id: A0A8J0TSN7
uniprot id: A0A8J1LLH5
uniprot id: A0A8J1LMJ5
names: Similarity
messages: Belongs to the MHC class I family.

8355:LOC108718943
gene id: 8355:LOC108718943
uniprot id: A0A1L8FWE0
uniprot id: A0A8J0VKC1
uniprot id: A0A8J0VNR5
uniprot id: A0A974CM63
names: Similarity
messages: Belongs to the TRIM/RBCC family.

8355:ccnb1.L
gene id: 8355:ccnb1.L
uniprot id: A0A1L8I241
uniprot id: A0A974E2L1
names: Similarity
messages: Belongs to the cyclin family.

8355:LOC108697845
gene id: 8355:LOC108697845
uniprot id: A0A1L8FHH7
uniprot id: A0A8J1LFF9
uniprot id: A0A974HAP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVBP family.
messages: Secreted
messages: cytoskeleton

8355:LOC108713537
gene id: 8355:LOC108713537
uniprot id: A0A8J1MYS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

8355:cnot2.L
gene id: 8355:cnot2.L
uniprot id: A0A1L8GYK2
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

8355:clstn2.S
gene id: 8355:clstn2.S
uniprot id: A0A8J0VHA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsyntenin family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Postsynaptic cell membrane

8355:gadl1.L
gene id: 8355:gadl1.L
uniprot id: A0A1L8FWG1
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

8355:LOC108702365
gene id: 8355:LOC108702365
uniprot id: A0A1L8EKY2
uniprot id: A0A974BSS8
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

8355:smc1a.S
gene id: 8355:smc1a.S
uniprot id: A0A1L8F1L3
uniprot id: A0A974C2X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

8355:gkap1.S
gene id: 8355:gkap1.S
uniprot id: A0A8J0TP01
uniprot id: Q8AVX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GKAP1 family.
messages: Golgi apparatus
messages: May play a role in the regulation of insulin-dependent IRS1 tyrosine phosphorylation in adipocytes.

8355:dgcr2.S
gene id: 8355:dgcr2.S
uniprot id: A0A1L8HQD5
uniprot id: A0A8J0U038
uniprot id: A0A8J0U043
uniprot id: A0A974DWJ9
uniprot id: Q6GM11
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:scnn1a.L
gene id: 8355:scnn1a.L
uniprot id: P51167
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Heterotrimer containing an alpha/SCNN1A, a beta/SCNN1B and a gamma/SCNN1G subunit. An additional delta/SCNN1D subunit exists only in some organisms and can replace the alpha/SCNN1A subunit to form an alternative channel with specific properties (Probable). Interacts with shroom1 (PubMed:10438504).
messages: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.
messages: acrosome
messages: cilium
messages: flagellum

8355:LOC108707541
gene id: 8355:LOC108707541
uniprot id: A0A8J1M9L8
uniprot id: A0A8J1M9L9
uniprot id: A0A8J1M9M4
uniprot id: A0A8J1M9W1
uniprot id: A0A8J1MAM7
uniprot id: A0A8J1MBF0
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

8355:tmed1.L
gene id: 8355:tmed1.L
uniprot id: A0A8J0UMW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

8355:slco1b3.L
gene id: 8355:slco1b3.L
uniprot id: A0A1L8GVV4
uniprot id: A0A974HRT8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:ndc1.L
gene id: 8355:ndc1.L
uniprot id: A0A8J0V6H3
uniprot id: A0A8J1MX06
uniprot id: A0A8J1MYQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDC1 family.
messages: Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.
messages: Membrane
messages: Nucleus membrane
messages: nuclear pore complex

8355:desi2.L
gene id: 8355:desi2.L
uniprot id: A0A974CW40
uniprot id: Q5PQ09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeSI family.
messages: Cytoplasm
messages: Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

8355:slc2a2.S
gene id: 8355:slc2a2.S
uniprot id: A0A1L8G481
uniprot id: A0A8J1KU41
uniprot id: A0A974CUD0
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

8355:LOC121402939
gene id: 8355:LOC121402939
uniprot id: A0A8J1MX22
names: Subcellular Location Annotation
messages: Membrane

8355:dtd1.L
gene id: 8355:dtd1.L
uniprot id: A0A974HJ69
uniprot id: Q6DEC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DTD family.
messages: Cytoplasm

8355:bfsp1.L
gene id: 8355:bfsp1.L
uniprot id: Q6DKC1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: cell cortex
messages: cytoskeleton

8355:znf652.L
gene id: 8355:znf652.L
uniprot id: Q6GNP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

8355:slc7a6os.L
gene id: 8355:slc7a6os.L
uniprot id: A2BDB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IWR1/SLC7A6OS family.
messages: Cytoplasm
messages: Directs RNA polymerase II nuclear import.
messages: Nucleus

8355:LOC108702718
gene id: 8355:LOC108702718
uniprot id: A0A8J0TS54
uniprot id: A0A8J0TZH5
uniprot id: A0A8J1LY49
uniprot id: A0A8J1LY55
uniprot id: A0A8J1LY61
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events.

8355:LOC108701904
gene id: 8355:LOC108701904
uniprot id: A0A1L8EYD0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:polr3a.L
gene id: 8355:polr3a.L
uniprot id: Q7ZXW5
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

8355:pop7.L
gene id: 8355:pop7.L
uniprot id: A0A1L8H4F4
uniprot id: A0A974HV04
uniprot id: A1A610
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone-like Alba family.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
messages: nucleolus

8355:sult2b1.S
gene id: 8355:sult2b1.S
uniprot id: A0A1L8FGT8
uniprot id: A0A974CDA5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8355:tyw1.S
gene id: 8355:tyw1.S
uniprot id: Q2KHP8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the TYW1 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity).

8355:man2a1.S
gene id: 8355:man2a1.S
uniprot id: A0A8J1M3V4
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

8355:usp34.S
gene id: 8355:usp34.S
uniprot id: A0A1L8G0N1
uniprot id: A0A974CQA5
names: Similarity
messages: Belongs to the peptidase C19 family.

8355:tmem120a.L
gene id: 8355:tmem120a.L
uniprot id: A0A974DN42
uniprot id: A1L2R7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Cell membrane
messages: Ion channel involved in sensing mechanical pain. Contributes to mechanosensitive currents in nocireceptors and detecting mechanical pain stimuli. May also be required for efficient adipogenesis.
messages: Membrane
messages: Nucleus inner membrane

8355:LOC108714365
gene id: 8355:LOC108714365
uniprot id: A0A8J0V2R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

8355:adh5.L
gene id: 8355:adh5.L
uniprot id: A0A974I356
uniprot id: Q4V813
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

8355:adgrf1.S
gene id: 8355:adgrf1.S
uniprot id: A0A1L8G597
uniprot id: A0A974CSW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

8355:sppl3.S
gene id: 8355:sppl3.S
uniprot id: A0A1L8HQ74
uniprot id: A0A974I1J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

8355:tsnare1l.S
gene id: 8355:tsnare1l.S
uniprot id: A0A1L8FQ79
uniprot id: A0A8J0T5F8
uniprot id: A0A974CI45
names: Similarity
messages: Belongs to the CDR2 family.

8355:slc30a9.L
gene id: 8355:slc30a9.L
uniprot id: A0A1L8HTM8
uniprot id: A0A974DWI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Endoplasmic reticulum
messages: Membrane
messages: Mitochondrion membrane
messages: Nucleus

8355:tlcd2.L
gene id: 8355:tlcd2.L
uniprot id: A0A1L8HDL8
uniprot id: A0A974DN26
names: Subcellular Location Annotation
messages: Membrane

8355:arsk.L
gene id: 8355:arsk.L
uniprot id: Q0IHJ2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Catalyzes the hydrolysis of pseudosubstrates such as p-nitrocatechol sulfate and p-nitrophenyl sulfate (By similarity). Catalyzes the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate (By similarity). Acts selectively on 2-sulfoglucuronate and lacks activity against 2-sulfoiduronate (By similarity).
messages: Lysosome
messages: Secreted
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

8355:nit1.S
gene id: 8355:nit1.S
uniprot id: A0A1L8F521
uniprot id: A0A8J1LMW9
uniprot id: A0A974C6A4
uniprot id: Q66KS6
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

8355:fam149b1.S
gene id: 8355:fam149b1.S
uniprot id: A0A1L8FEZ2
uniprot id: A0A8J0TEV4
uniprot id: A0A974CCR7
names: Similarity
messages: Belongs to the FAM149 family.

8355:LOC108717215
gene id: 8355:LOC108717215
uniprot id: A0A1L8GCA8
uniprot id: A0A974CZA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

8355:polrmt.L
gene id: 8355:polrmt.L
uniprot id: A0A8J0TDZ8
uniprot id: Q9PTG7
names: Function
names: Similarity
messages: Belongs to the phage and mitochondrial RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

8355:LOC108718104
gene id: 8355:LOC108718104
uniprot id: A0A1L8G420
uniprot id: A0A8J0VFW6
uniprot id: A0A974HHX6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum membrane
messages: Interacts with sptlc1; the interaction is direct. Component of the serine palmitoyltransferase (SPT) complex.
messages: Membrane
messages: Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference.

8355:slc66a2.2.L
gene id: 8355:slc66a2.2.L
uniprot id: A0A1L8GKX6
uniprot id: A0A974D3M4
names: Subcellular Location Annotation
messages: Membrane

8355:rpl15.S
gene id: 8355:rpl15.S
uniprot id: A0A1L8FRG2
uniprot id: A0A974HDQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Cytoplasm

8355:mff.S
gene id: 8355:mff.S
uniprot id: A0A1L8G4S2
uniprot id: A0A8J0VAJ1
uniprot id: A0A8J0VDT0
uniprot id: A0A8J1KVZ2
uniprot id: A0A974HIA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tango11 family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.

8355:esco2.S
gene id: 8355:esco2.S
uniprot id: A0A8J0Q454
uniprot id: Q4KLP7
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108708176
gene id: 8355:LOC108708176
uniprot id: A0A1L8HEZ1
uniprot id: A0A8J0U6P0
uniprot id: A0A8J0UDK4
uniprot id: A0A974DMD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

8355:LOC121400471
gene id: 8355:LOC121400471
uniprot id: A0A8J1MEP5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:axin2.S
gene id: 8355:axin2.S
uniprot id: A0A8J0TD29
uniprot id: A0A974CD98
uniprot id: Q641H3
names: Subcellular Location Annotation
messages: Cytoplasm

8355:LOC108716097
gene id: 8355:LOC108716097
uniprot id: A0A1L8I0P3
uniprot id: A0A974E1B3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:nol11.L
gene id: 8355:nol11.L
uniprot id: A0A8J0TS86
uniprot id: A0A8J0TTA2
uniprot id: A0A974H3K8
uniprot id: A2BD95
names: Subcellular Location Annotation
messages: nucleolus

8355:LOC108709321
gene id: 8355:LOC108709321
uniprot id: A0A1L8H5Y4
uniprot id: A0A974DGD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the claudin family.
messages: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8355:mtcp1.L
gene id: 8355:mtcp1.L
uniprot id: A0A1L8F6Q6
uniprot id: A0A974C686
names: Similarity
messages: Belongs to the CMC4 family.

8355:eif4a1.S
gene id: 8355:eif4a1.S
uniprot id: Q6AZL6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: Cytoplasm
messages: Nucleus
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

8355:LOC108703553
gene id: 8355:LOC108703553
uniprot id: A0A8J0U3D9
names: Similarity
messages: Belongs to the NXPE family.

8355:sdc2.L
gene id: 8355:sdc2.L
uniprot id: A0A974CP72
uniprot id: Q3KQ99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

8355:rxfp4.L
gene id: 8355:rxfp4.L
uniprot id: A0A8J1LLC1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:wee2.S
gene id: 8355:wee2.S
uniprot id: O57473
names: Caution
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Absent in stage VI oocytes and is expressed from meiosis II until gastrulation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Interacts with cdca3.
messages: Nucleus
messages: Oocyte and early embryo-specific protein tyrosine kinase that phosphorylates and inhibits cdk1 and acts as a regulator of meiosis in oocytes. Required to ensure the meiotic cell cycle in oocytes by phosphorylating cdk1 at 'Tyr-15', leading to inhibit cdk1 activity and prevent meiosis.
messages: Phosphorylated during M and G1 phases. Interacts with cdca3 when phosphorylated at Ser-38.
messages: Ubiquitinated and degraded at the onset of G2/M phase.
messages: Was initially assigned as wee1 (PubMed:9486797). However, it corresponds to the meiosis-specific protein WEE2 in mammals.

8355:bok.L
gene id: 8355:bok.L
uniprot id: A0A1L8GB63
uniprot id: A0A974HKL1
names: Similarity
messages: Belongs to the Bcl-2 family.

8355:mdm2.L
gene id: 8355:mdm2.L
uniprot id: A0A1L8GYI7
uniprot id: A0A8J0UQZ7
uniprot id: A0A8J0UU55
uniprot id: A0A974DBN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

8355:nnmt.L
gene id: 8355:nnmt.L
uniprot id: A0A974CH63
uniprot id: Q7SZ76
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8355:dars1.S
gene id: 8355:dars1.S
uniprot id: A0A974BUF0
uniprot id: Q8AVK0
names: Function
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.

8355:tsc22d2.S
gene id: 8355:tsc22d2.S
uniprot id: A0A8J1KRE8
uniprot id: Q6NU54
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

8355:cryab.L
gene id: 8355:cryab.L
uniprot id: A0A8J0T2B8
uniprot id: A0A8J1L6R6
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

8355:zfx.S
gene id: 8355:zfx.S
uniprot id: Q6NRV1
names: Subcellular Location Annotation
messages: Nucleus

8355:prrx2.L
gene id: 8355:prrx2.L
uniprot id: A0A8J0U5D3
uniprot id: A0A8J0U858
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

8355:bdkrb2.L
gene id: 8355:bdkrb2.L
uniprot id: A0A1L8F9L7
uniprot id: A0A974C833
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.
messages: Membrane
messages: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

8355:dbf4b.L
gene id: 8355:dbf4b.L
uniprot id: Q283Q6
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Forms a complex with cdc7.
messages: Nucleus
messages: Phosphorylated. Stably phosphorylated throughout the cell cycle.
messages: Present early in development. During oogenesis and maturation, low levels are detected in growing oocyte stages V-VI. Expression increases significantly during oocyte maturation. After fertilization, the level decreases slowly until the mid-blastula transition (MBT, stage 8.5). A sharper decrease occurs after MBT. Not detected in embryos past stage 10 of development (at protein level).
messages: Regulatory subunit for cdc7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Specifically required during the initiation of DNA replication in egg and during early embryonic development. The complex cdc7-dbf4b phosphorylates mcm2 and mcm4 subunits and is required for cdc45 loading.

8355:pde4a.S
gene id: 8355:pde4a.S
uniprot id: A0A8J1MPA6
uniprot id: A0A8J1MPE9
uniprot id: A0A8J1MQB0
uniprot id: A0A8J1MRG0
uniprot id: Q5XGT5
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8355:LOC108717413
gene id: 8355:LOC108717413
uniprot id: A0A1L8G2D2
names: Subcellular Location Annotation
messages: Membrane

8355:atp2c1.S
gene id: 8355:atp2c1.S
uniprot id: A0A1L8FWI7
uniprot id: A0A8J1KXE3
uniprot id: A0A8J1L0C1
uniprot id: A0A974CM45
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:exoc3l2.L
gene id: 8355:exoc3l2.L
uniprot id: A0A1L8F841
uniprot id: A0A8J1LGR8
names: Similarity
messages: Belongs to the SEC6 family.

8355:baz1b.L
gene id: 8355:baz1b.L
uniprot id: A0A1L8HDI8
uniprot id: A0A974DMJ9
names: Subcellular Location Annotation
messages: Nucleus

8355:glrx.S
gene id: 8355:glrx.S
uniprot id: A0A1L8HR55
uniprot id: A0A974DV68
names: Function
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

8355:ociad1.L
gene id: 8355:ociad1.L
uniprot id: A0A8J0QFF8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OCIAD1 family.
messages: Endosome
messages: Interacts with STAT3.
messages: Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.
messages: The OCIA domain is necessary and sufficient for endosomal localization.

8355:mrpl49.L
gene id: 8355:mrpl49.L
uniprot id: A0A1L8GJK9
uniprot id: A0A974D459
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL49 family.
messages: Mitochondrion

8355:gper1.L
gene id: 8355:gper1.L
uniprot id: A0A8J0TYK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:jade3.S
gene id: 8355:jade3.S
uniprot id: A0A8J1MBB0
uniprot id: A0A8J1MC01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMP-30/CGR1 family.
messages: Cytoplasm

8355:LOC432208
gene id: 8355:LOC432208
uniprot id: Q4V7X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

8355:pkp2.S
gene id: 8355:pkp2.S
uniprot id: A0A8J1MQX6
names: Similarity
messages: Belongs to the beta-catenin family.

8355:nodal6.L
gene id: 8355:nodal6.L
uniprot id: A0A974HUB8
uniprot id: Q9DEF0
names: Similarity
messages: Belongs to the TGF-beta family.

8355:slc25a48.L
gene id: 8355:slc25a48.L
uniprot id: A0A1L8GWW3
uniprot id: A0A8J0UQ51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8355:smarcd3.S
gene id: 8355:smarcd3.S
uniprot id: A0A1L8EL76
uniprot id: A0A8J1LWD7
uniprot id: Q52L33
names: Similarity
messages: Belongs to the SMARCD family.

8355:XB5863530.L
gene id: 8355:XB5863530.L
uniprot id: Q6GMA9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8355:LOC121401274
gene id: 8355:LOC121401274
uniprot id: A0A1L8H2B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:bok.S
gene id: 8355:bok.S
uniprot id: A0A1L8G4M6
uniprot id: A0A974CSY7
uniprot id: B9ZYL8
names: Similarity
messages: Belongs to the Bcl-2 family.

8355:LOC108697397
gene id: 8355:LOC108697397
uniprot id: A0A8J1LBD9
uniprot id: A0A8J1LBJ1
uniprot id: A0A8J1LD00
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

8355:LOC108710432
gene id: 8355:LOC108710432
uniprot id: A0A1L8H3K5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:ccni.L
gene id: 8355:ccni.L
uniprot id: A0A974E036
uniprot id: Q6P7H3
names: Similarity
messages: Belongs to the cyclin family.

8355:adipor1.S
gene id: 8355:adipor1.S
uniprot id: A0A974HVZ2
uniprot id: Q7ZY04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

8355:nr2e1.S
gene id: 8355:nr2e1.S
uniprot id: P70052
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Monomer.
messages: Nucleus
messages: Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). Involved in the regulation of early eye development.
messages: Prominent expression in the embryonal optic stalk and the distal tip of the forming vesicle. In tadpole-stage embryos predominantly found in the ciliary margin of the optic cup.

8355:zranb2.S
gene id: 8355:zranb2.S
uniprot id: A3KND4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZRANB2 family.
messages: May interfere with constitutive 5'-splice site selection.
messages: Nucleus

8355:cryba1.2.S
gene id: 8355:cryba1.2.S
uniprot id: A0A1L8H4T8
uniprot id: A0A974DHE8
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:primpol.L
gene id: 8355:primpol.L
uniprot id: A0A1L8HU35
uniprot id: A0A8J0TLS9
uniprot id: A0A8J1MUI5
uniprot id: A0A974DWV5
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

8355:LOC108702352
gene id: 8355:LOC108702352
uniprot id: A0A8J0TYE9
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8355:tgfb2.L
gene id: 8355:tgfb2.L
uniprot id: A0A974HIK0
uniprot id: P17247
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked (By similarity). Interacts with TGF-beta receptors (tgfbr1 and tgfbr2), leading to signal transduction (By similarity).
messages: Homodimer; disulfide-linked.
messages: Interacts with Transforming growth factor beta-2 (TGF-beta-2) chain; interaction is non-covalent and maintains (TGF-beta-2) in a latent state (By similarity).
messages: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as ltbp1 and lrrc32/garp, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus (By similarity). Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (tgfbr1 and tgfbr2), which transduce signal (By similarity).
messages: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
messages: Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as ltbp1 and lrrc32/garp, that control activation of TGF-beta-2.
messages: Secreted
messages: The precursor proprotein is cleaved in the Golgi apparatus to form Transforming growth factor beta-2 (TGF-beta-2) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-2 inactive.
messages: extracellular matrix

8355:mchr2.S
gene id: 8355:mchr2.S
uniprot id: A0A8J0VCG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC121399122
gene id: 8355:LOC121399122
uniprot id: A0A8J1M105
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

8355:slc22a18.L
gene id: 8355:slc22a18.L
uniprot id: A0A1L8GI77
uniprot id: A0A8J1MUM4
uniprot id: A0A8J1MW51
uniprot id: A0A8J1MX27
uniprot id: A0A974HMU9
names: Subcellular Location Annotation
messages: Membrane

8355:slc26a2.L
gene id: 8355:slc26a2.L
uniprot id: A0A8J0UTJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions. The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange. Essential for chondrocyte proliferation, differentiation and cell size expansion.

8355:snapc3.L
gene id: 8355:snapc3.L
uniprot id: A0A1L8HY22
uniprot id: A0A974I3U9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAPC3/SRD2 family.
messages: Nucleus
messages: Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.
messages: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

8355:rpl11.L
gene id: 8355:rpl11.L
uniprot id: A0A1L8HFU5
uniprot id: A0A974DP64
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

8355:rnf112.1.S
gene id: 8355:rnf112.1.S
uniprot id: A0A1L8ERI6
uniprot id: A0A974H227
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8355:c12orf57.L
gene id: 8355:c12orf57.L
uniprot id: A0A974HB00
uniprot id: Q6AX50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0456 family.
messages: Cytoplasm

8355:adra2b.S
gene id: 8355:adra2b.S
uniprot id: A0A1L8GS17
uniprot id: A0A974D6T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108717150
gene id: 8355:LOC108717150
uniprot id: A0A8J1KRQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

8355:msn.L
gene id: 8355:msn.L
uniprot id: A0A8J0U464
uniprot id: Q4V7Z2
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

8355:tmem38b.L
gene id: 8355:tmem38b.L
uniprot id: A0A974E0C3
uniprot id: Q6GN30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM38 family.
messages: Endoplasmic reticulum membrane
messages: Homotrimer; trimerization probably requires binding to phosphatidylinositol 4,5-bisphosphate (PIP2).
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

8355:XB5805949.S
gene id: 8355:XB5805949.S
uniprot id: A0A1L8H4T4
uniprot id: A0A974DFS1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: gap junction

8355:LOC121395506
gene id: 8355:LOC121395506
uniprot id: A0A8J1L660
names: Subcellular Location Annotation
messages: Membrane

8355:ncam1.S
gene id: 8355:ncam1.S
uniprot id: P16170
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell membrane
messages: Expressed in neuron and in presumptive neural tissue.
messages: The mRNA encoding this LD-NCAM is the major transcript present in both maternal RNA and in the embryo during early neural development.
messages: This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.

8355:cyp27a1
gene id: 8355:cyp27a1
uniprot id: A0A8J1LW12
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:LOC108701260
gene id: 8355:LOC108701260
uniprot id: A0A1L8EVD7
uniprot id: A0A974BYS5
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:tnks.S
gene id: 8355:tnks.S
uniprot id: A0A8J1M8H5
uniprot id: A0A8J1M9H7
uniprot id: A0A8J1M9I1
uniprot id: Q5XGK5
names: Similarity
messages: Belongs to the ARTD/PARP family.

8355:lsm3.L
gene id: 8355:lsm3.L
uniprot id: A0A1L8GPJ8
uniprot id: A0A974HQ38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

8355:LOC108700404
gene id: 8355:LOC108700404
uniprot id: A0A1L8F504
uniprot id: A0A974C578
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

8355:phc1.S
gene id: 8355:phc1.S
uniprot id: A0A8J0TDY1
uniprot id: A0JMR9
names: Subcellular Location Annotation
messages: Nucleus

8355:rbbp5.S
gene id: 8355:rbbp5.S
uniprot id: A0A8J0UL52
uniprot id: A0A8J1MBM8
uniprot id: A0A8J1MCM0
uniprot id: A0A8J1MDE2
uniprot id: A0A974DH27
uniprot id: Q6DE48
names: Subcellular Location Annotation
messages: Nucleus

8355:ust.S
gene id: 8355:ust.S
uniprot id: A0A1L8G2J0
uniprot id: A0A974HH93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:ppm1a.L
gene id: 8355:ppm1a.L
uniprot id: A0A8J0TL20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

8355:atp5f1b.S
gene id: 8355:atp5f1b.S
uniprot id: A0A974HWT8
uniprot id: Q7ZWR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

8355:atp5mc3.S
gene id: 8355:atp5mc3.S
uniprot id: A0A974BUY5
uniprot id: Q8AVE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

8355:aimp2.L
gene id: 8355:aimp2.L
uniprot id: Q7ZYD7
names: Subcellular Location Annotation
messages: Nucleus
messages: cytosol

8355:foxh1.2.L
gene id: 8355:foxh1.2.L
uniprot id: Q8JIT7
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: ARF2 contains 2 smad2s, 1 smad4 and 1 fast3 protein. Interacts with the MH2 domain of smad2. The ARF1 and ARF2 complexes are activated by distinct TGFbeta family members; formation of ARF2 is promoted by derriere and vegt.
messages: Expressed only during gastrulation.
messages: Highly expressed in the animal cap (prospective ectoderm) and prospective mesoderm of stage 10.25 embryos.
messages: Nucleus
messages: The FM region is required for binding smad2/smad4 complexes. FM2 is more effective than FM1 and only interacts with phosphorylated smad2 that is in an activated smad complex.
messages: Transcriptional activator. Upon TGF-beta induction, forms a transcriptionally active complex with smad2 and smad4 called activin-responsive factor 2 (ARF2), which binds a site on the mix-B/mix.2 promoter called the activin response element (ARE). Binds to activated smads and the ARE with much higher affinity than foxh1/fast-1. Acts with foxh1/fast-1 to control the convergent extension movements of gastrulation.

8355:tpm1.L
gene id: 8355:tpm1.L
uniprot id: Q01173
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tropomyosin family.
messages: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
messages: Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain.
messages: The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
messages: cytoskeleton

8355:prdm6.S
gene id: 8355:prdm6.S
uniprot id: A0A1L8HQZ8
uniprot id: A0A974I229
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108706280
gene id: 8355:LOC108706280
uniprot id: A0A8J1MAC7
names: Subcellular Location Annotation
messages: Membrane

8355:enah.S
gene id: 8355:enah.S
uniprot id: A0A1L8G107
uniprot id: A0A8J0VEJ7
uniprot id: A0A8J0VIY9
uniprot id: A0A974CPZ1
uniprot id: Q4V859
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: cytoskeleton

8355:LOC121400426
gene id: 8355:LOC121400426
uniprot id: A0A8J1MD25
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC108702166
gene id: 8355:LOC108702166
uniprot id: A0A8J0TY54
names: Subcellular Location Annotation
messages: Membrane

8355:notch2.L
gene id: 8355:notch2.L
uniprot id: A0A8J0V3A6
uniprot id: A0A8J1MZA0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

8355:wdr45.S
gene id: 8355:wdr45.S
uniprot id: Q6DCV0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (By similarity). Binds phosphatidylinositol 3-phosphate (PtdIns3P) (By similarity).
messages: Preautophagosomal structure
messages: The L/FRRG motif is required for recruitment to PtdIns3P.

8355:tfap2e.L
gene id: 8355:tfap2e.L
uniprot id: A0A974DMP4
uniprot id: Q2T9K2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AP-2 family.
messages: Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity).
messages: Nucleus
messages: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions (By similarity).

8355:psmf1.L
gene id: 8355:psmf1.L
uniprot id: A0A974BX51
uniprot id: Q5XGW2
names: Similarity
messages: Belongs to the proteasome inhibitor PI31 family.

8355:phf23l.L
gene id: 8355:phf23l.L
uniprot id: Q0IHB0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a negative regulator of autophagy.
messages: Belongs to the PHF23 family.
messages: Cytoplasm
messages: Nucleus
messages: The PHD-type zinc-finger domain is required for negative regulation of autophagy.

8355:LOC100127300
gene id: 8355:LOC100127300
uniprot id: A0A8J0TGM9
uniprot id: A9JS41
names: Similarity
messages: Belongs to the S-100 family.

8355:hsd17b10.L
gene id: 8355:hsd17b10.L
uniprot id: Q6DCM8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8355:zic5.L
gene id: 8355:zic5.L
uniprot id: A0A1L8HH76
uniprot id: A0A974DNT1
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

8355:LOC108695235
gene id: 8355:LOC108695235
uniprot id: A0A1L8FSK6
uniprot id: A0A974HE36
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane

8355:neurod4.L
gene id: 8355:neurod4.L
uniprot id: A0A1L8HIF8
uniprot id: A0A974DQT7
uniprot id: P79920
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Efficient DNA binding requires dimerization with another bHLH protein (By similarity). Forms a heterodimer with the bHLH protein hes2, and weakly interacts with hey1/hrt1.
messages: First expressed weakly at stage 12 in primary neuronal precursors. At stages 18 and 21, strongly expressed in the cranial ganglions, with weaker expression remaining in the spinal cord. Later, strongly expressed at sites of neuronal differentiation, namely the eye, forebrain and cranial ganglions.
messages: Nucleus
messages: Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina (By similarity).
messages: Serine or threonine phosphorylation within the basic region may regulate neurogenic activity.

8355:camk4.L
gene id: 8355:camk4.L
uniprot id: A0A8J0UR59
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:fmr1.L
gene id: 8355:fmr1.L
uniprot id: P51113
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the FMR1 family.
messages: Cell membrane
messages: Chromosome
messages: Cytoplasmic ribonucleoprotein granule
messages: During early to late tailbud stage, expression intensifies in the craniofacial region with prominent staining in the endodermal, mesodermal and mesenchymal regions of the pharyngeal arches. By early tadpole stage (stage 35), expressed in the forebrain, midbrain, hindbrain and notochord in addition to craniofacial regions including the ear vesicles and eye. In the central nervous system (CNS) of late tadpoles (stage 45), expressed in the olfactory bulbs and the cerebellum. In adults, expressed predominantly in the brain.
messages: Expressed both maternally and zygotically. Zygotic expression begins just prior to gastrulation (stage 10) and gradually increases during subsequent embryonic stages.
messages: Homodimer. Heterodimer.
messages: Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of target mRNAs (By similarity). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Binds poly(G) and poly(U), and to a lower extent poly(A) and poly(C) (PubMed:7781595).
messages: Nucleus
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Presynaptic cell membrane
messages: Stress granule
messages: Synapse
messages: The C-terminal disordered region undergoes liquid-liquid phase separation (LLPS) for the formation of a membraneless compartment that concentrates mRNAs with associated regulatory factors.
messages: axon
messages: centromere
messages: dendrite
messages: dendritic spine
messages: filopodium tip
messages: growth cone
messages: neuron projection
messages: nucleolus
messages: perinuclear region
messages: synaptosome

8355:thoc7.S
gene id: 8355:thoc7.S
uniprot id: A0A974D344
uniprot id: Q7SZ78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THOC7 family.
messages: Component of the THO subcomplex of the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling.
messages: Cytoplasm
messages: Nucleus
messages: Nucleus speckle
messages: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.

8355:ndel1.S
gene id: 8355:ndel1.S
uniprot id: A0A1L8EN91
uniprot id: A0A8J1LW71
uniprot id: A0A8J1LYD6
uniprot id: A0A974BU20
uniprot id: Q66IZ7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudE family.
messages: Phosphorylated in mitosis.
messages: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts.
messages: centrosome
messages: cytoskeleton
messages: spindle

8355:patj.L
gene id: 8355:patj.L
uniprot id: A0A8J1MWU0
uniprot id: A0A8J1MXZ9
uniprot id: A0A8J1MYI3
uniprot id: A0A8J1MZB0
names: Subcellular Location Annotation
messages: tight junction

8355:adss2.L
gene id: 8355:adss2.L
uniprot id: Q7ZY87
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Inhibited competitively by AMP and IMP and non-competitively by fructose 1,6-bisphosphate.
messages: Mitochondrion
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

8355:sod2.S
gene id: 8355:sod2.S
uniprot id: A0A974HHC3
uniprot id: Q6GP18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homotetramer.
messages: Mitochondrion matrix

8355:LOC108698465
gene id: 8355:LOC108698465
uniprot id: A0A1L8F7T6
uniprot id: A0A974C6J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:usp7.L
gene id: 8355:usp7.L
uniprot id: A0A1L8EXJ7
uniprot id: A0A8J0TNB1
uniprot id: A0A8J0TVD3
uniprot id: A0A8J0TWX8
uniprot id: A0A974H4E8
names: Similarity
messages: Belongs to the peptidase C19 family.

8355:ccr3.L
gene id: 8355:ccr3.L
uniprot id: A0A1L8FX05
uniprot id: A0A8J0VI74
uniprot id: A0A974HFX4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:psmc6.L
gene id: 8355:psmc6.L
uniprot id: A0A1L8F9T2
uniprot id: A0A974H830
names: Similarity
messages: Belongs to the AAA ATPase family.

8355:tmem41b.S
gene id: 8355:tmem41b.S
uniprot id: A0A1L8GE68
uniprot id: A0A974D089
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

8355:tshz2.S
gene id: 8355:tshz2.S
uniprot id: A0A8J0TZ47
names: Similarity
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.

8355:mrpl9.S
gene id: 8355:mrpl9.S
uniprot id: A0A8J1LKZ1
uniprot id: Q5U4L3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

8355:LOC108697485
gene id: 8355:LOC108697485
uniprot id: A0A8J1L787
uniprot id: A0A8J1L9V1
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:scnn1b.S
gene id: 8355:scnn1b.S
uniprot id: O13262
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1B subfamily.
messages: Cytoplasmic vesicle membrane
messages: Heterotrimer containing an alpha/SCNN1A, a beta/SCNN1B and a gamma/SCNN1G subunit. An additional delta/SCNN1D subunit exists only in some organisms and can replace the alpha/SCNN1A subunit to form an alternative channel with specific properties.
messages: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.

8355:atxn3.S
gene id: 8355:atxn3.S
uniprot id: A0A1L8F0I3
uniprot id: A0A8J0TFQ8
uniprot id: A0A8J0TNF7
uniprot id: A0A974H5B4
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108697976
gene id: 8355:LOC108697976
uniprot id: A0A1L8FGG4
uniprot id: A0A974CCM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:cyb5b.S
gene id: 8355:cyb5b.S
uniprot id: A0A1L8GF07
uniprot id: A0A8J0V6U0
uniprot id: A0A974HLU8
names: Similarity
messages: Belongs to the cytochrome b5 family.

8355:bloc1s1.S
gene id: 8355:bloc1s1.S
uniprot id: Q640Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BLOC1S1 family.
messages: Mitochondrion intermembrane space

8355:LOC108715924
gene id: 8355:LOC108715924
uniprot id: A0A8J1KLU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

8355:ccdc124.L
gene id: 8355:ccdc124.L
uniprot id: A0A1L8HXF1
uniprot id: A0A974E0E7
uniprot id: Q68EY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with translationally inactive ribosomes in the nonrotated state.
messages: Belongs to the CCDC124 family.
messages: Midbody
messages: Ribosome-binding protein involved in ribosome hibernation: associates with translationally inactive ribosomes and stabilizes the nonrotated conformation of the 80S ribosome, thereby promoting ribosome preservation and storage.
messages: centrosome

8355:paqr6.S
gene id: 8355:paqr6.S
uniprot id: A0A8J1LM25
uniprot id: A0A8J1LNB4
uniprot id: Q6AX66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

8355:rps16.L
gene id: 8355:rps16.L
uniprot id: Q6INX6
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

8355:plod2.S
gene id: 8355:plod2.S
uniprot id: A0A1L8G4J2
uniprot id: A0A8J0VG14
uniprot id: A0A974HIF6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

8355:LOC121401602
gene id: 8355:LOC121401602
uniprot id: A0A8J1MNN0
names: Similarity
messages: Belongs to the SNF7 family.

8355:clec3a.L
gene id: 8355:clec3a.L
uniprot id: Q66KU1
names: Subcellular Location Annotation
messages: Secreted

8355:irx1.S
gene id: 8355:irx1.S
uniprot id: Q2TAQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Acts early in neural plate development to induce expression of some but not all proneural genes, and specify a neural precursor state. Also up-regulates repressors that prevent neuronal differentiation. Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes. Acts primarily as a transcriptional repressor during neural development, and binds to the bmp4 promoter to repress gene expression and thus mediate down-regulation of bmp4 by wnt signaling. Controls multiple processes through bmp4-repression including neural plate development, neural crest specification and Spemann organizer development. Involved in the specification of the preplacodal field at the anterior border of the neural plate. Regulates the genetic cascade of interactions that are necessary for positioning the isthmus organizer and the formation of the midbrain-hindbrain boundary. Required during at least two stages of pronephros kidney development; during neurula stages, maintains transcription of key renal genes to define the size and identity of the pronephric anlage, probably in part through regulation of bmp-signaling. Subsequently required for proper formation of the intermediate tubule segment of the pronephros. Acts principally as a transcriptional activator during pronephros development (By similarity).
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

8355:LOC108705591
gene id: 8355:LOC108705591
uniprot id: A0A310U7K0
uniprot id: A0A974BQF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:fbn1.S
gene id: 8355:fbn1.S
uniprot id: A0A1L8GSW8
uniprot id: A0A974HR69
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8355:slc4a8.L
gene id: 8355:slc4a8.L
uniprot id: A0A8J0UGU8
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

8355:LOC108715635
gene id: 8355:LOC108715635
uniprot id: A0A1L8GG25
uniprot id: A0A8J0V7Q4
uniprot id: A0A974HLQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Nucleus

8355:LOC108699866
gene id: 8355:LOC108699866
uniprot id: A0A1L8F0R5
uniprot id: A0A974C2D9
names: Similarity
messages: Belongs to the CRISP family.

8355:rsph3.L
gene id: 8355:rsph3.L
uniprot id: A0A974CX59
uniprot id: Q08B05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flagellar radial spoke RSP3 family.
messages: flagellum axoneme

8355:dars2.L
gene id: 8355:dars2.L
uniprot id: A0A8J0V6I3
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.

8355:mfsd10.S
gene id: 8355:mfsd10.S
uniprot id: A0A1L8HKS8
uniprot id: A0A974DSM0
uniprot id: Q6NR99
names: Subcellular Location Annotation
messages: Membrane

8355:myo3a.L
gene id: 8355:myo3a.L
uniprot id: A0A1L8FVI1
uniprot id: A0A8J1KWW6
uniprot id: A0A8J1KWW8
uniprot id: A0A8J1KYI1
uniprot id: A0A974CLD9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: cytoskeleton

8355:limk2.S
gene id: 8355:limk2.S
uniprot id: A0A8J0U6S0
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

8355:vamp8.L
gene id: 8355:vamp8.L
uniprot id: A0A1L8H1L5
uniprot id: A0A974HTY3
uniprot id: Q5XGY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

8355:vkorc1l1.L
gene id: 8355:vkorc1l1.L
uniprot id: A0A1L8HG70
uniprot id: A0A974DNA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:rnf112l.L
gene id: 8355:rnf112l.L
uniprot id: A0A8J0U3G4
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8355:LOC108709170
gene id: 8355:LOC108709170
uniprot id: A0A8J0UJ62
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108699016
gene id: 8355:LOC108699016
uniprot id: A0A1L8FBG6
uniprot id: A0A974C9C9
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108714734
gene id: 8355:LOC108714734
uniprot id: A0A1L8GQ49
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

8355:ddx20.L
gene id: 8355:ddx20.L
uniprot id: A0A1L8HF67
uniprot id: A0A974DPT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family.
messages: Cytoplasm
messages: Nucleus

8355:nid2.S
gene id: 8355:nid2.S
uniprot id: A0A1L8F057
uniprot id: A0A974C1P7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

8355:LOC108701970
gene id: 8355:LOC108701970
uniprot id: A0A1L8EZD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Nucleus

8355:mpv17l.S
gene id: 8355:mpv17l.S
uniprot id: A0A974HAE1
uniprot id: Q68F62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane
messages: Participates in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes. Protective against the mitochondrial apoptotic cascade.
messages: Peroxisome membrane

8355:kcnk13.L
gene id: 8355:kcnk13.L
uniprot id: A0A1L8F9H3
uniprot id: A0A974C898
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

8355:adamts6.S
gene id: 8355:adamts6.S
uniprot id: A0A8J0U5L2
uniprot id: A0A8J1M464
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8355:mbp.S
gene id: 8355:mbp.S
uniprot id: A0A8J0VPT6
uniprot id: A0A974HE28
uniprot id: B2ZZ74
uniprot id: P87346
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As in other animals, several charge isomers may be produced as a result of optional post-translational modifications, such as phosphorylation of serine or threonine residues, deamidation of glutamine or asparagine residues, citrullination and methylation of arginine residues.
messages: Belongs to the myelin basic protein family.
messages: Homodimer.
messages: Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Plays a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity).
messages: Myelin membrane

8355:pde5a.S
gene id: 8355:pde5a.S
uniprot id: A0A8J0TZK7
uniprot id: A0A8J1LR42
uniprot id: A0A8J1LR52
uniprot id: Q5XH00
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8355:atp11c.S
gene id: 8355:atp11c.S
uniprot id: A0A1L8F3D1
uniprot id: A0A8J0TPV7
uniprot id: A0A8J1LND4
uniprot id: A0A974H5Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

8355:stxbp3.S
gene id: 8355:stxbp3.S
uniprot id: A0A1L8GGJ9
uniprot id: A0A974HM51
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

8355:LOC108716239
gene id: 8355:LOC108716239
uniprot id: A0A8J1KQ53
uniprot id: A0A8J1KT92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

8355:LOC108709468
gene id: 8355:LOC108709468
uniprot id: A0A1L8H6Y3
uniprot id: A0A8J0UN11
uniprot id: A0A974DH22
names: Subcellular Location Annotation
messages: Membrane

8355:nefh.L
gene id: 8355:nefh.L
uniprot id: A0A1L8HZT6
uniprot id: A0A974E1P2
names: Similarity
messages: Belongs to the intermediate filament family.

8355:ldlrap1.S
gene id: 8355:ldlrap1.S
uniprot id: Q801G1
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR). Also involved in the vitellogenin receptor mediated endocytosis of nutrients during oogenesis.
messages: Cytoplasm
messages: Expressed at high level during oogenesis and embryogenesis. Found in the oocyte vegetal cortex. Found at low level in the adult liver and spleen. Found at very low level in testis and heart.
messages: Expressed throughout oogenesis. Homogeneously distributed in stages I and II oocytes and only later localized primarily to the vegetal cortex. Expressed in early stage embryos, but expression decreases during gastrulation, reaching barely detectable levels by tailbud stages.
messages: Interacts (via PID domain) with ldlr (via NPXY motif) (PubMed:15327785). Binds to soluble clathrin trimers and to the adapter protein complex 2 (AP-2, beta 2 subunit). Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Interacts with the VLDL receptor (vldlr) (By similarity). Interacts with the vitellogenin receptor (PubMed:15327785).
messages: The PID domain mediates interaction with the NPXY internalization motif of LDLR.
messages: The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction the AP-2 complex subunit AP2B1.

8355:cdh19.S
gene id: 8355:cdh19.S
uniprot id: A0A1L8FSN4
uniprot id: A0A974HE53
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane

8355:rps3.S
gene id: 8355:rps3.S
uniprot id: P47835
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Has endonuclease activity and plays a role in repair of damaged DNA. Also involved in other processes including regulation of transcription, translation of its cognate mRNA, spindle formation and chromosome movement during mitosis, and apoptosis.
messages: Cytoplasm
messages: Mitochondrion inner membrane
messages: Nucleus
messages: nucleolus
messages: spindle

8355:kctd15.L
gene id: 8355:kctd15.L
uniprot id: Q6DCX3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: During embryonic development, interferes with neural crest formation. Inhibits AP2 transcriptional activity by interaction with its activation domain.
messages: Interacts with TFAP2A; this interaction inhibits TFAP2A transcriptional activation.
messages: Nucleus

8355:LOC108704874
gene id: 8355:LOC108704874
uniprot id: A0A8J1MKR5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

8355:ap1s1.L
gene id: 8355:ap1s1.L
uniprot id: A0A974DF67
uniprot id: Q6GQF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

8355:MGC81152
gene id: 8355:MGC81152
uniprot id: A0A8J0UA23
uniprot id: A0A8J0UGR6
uniprot id: A0A8J1MBC4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:LOC108712890
gene id: 8355:LOC108712890
uniprot id: A0A1L8GSR8
uniprot id: A0A8J0UWG5
uniprot id: A0A8J1MS76
uniprot id: A0A974D828
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8355:fth1.1.L
gene id: 8355:fth1.1.L
uniprot id: A0A974CI79
uniprot id: Q6PAB7
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

8355:fcf1.L
gene id: 8355:fcf1.L
uniprot id: A0A8J0T8L3
uniprot id: A0A974H856
uniprot id: Q6NUA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

8355:LOC108719597
gene id: 8355:LOC108719597
uniprot id: A0A8J1MDJ8
names: Subcellular Location Annotation
messages: Membrane

8355:MGC116491
gene id: 8355:MGC116491
uniprot id: A0A974CUJ9
uniprot id: Q4KLC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

8355:galnt4.L
gene id: 8355:galnt4.L
uniprot id: Q6IR91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8355:pla2g4f.L
gene id: 8355:pla2g4f.L
uniprot id: A0A1L8FAX9
uniprot id: A0A974C9X2
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

8355:dgkb.L
gene id: 8355:dgkb.L
uniprot id: A0A1L8FVW1
uniprot id: A0A8J1KX24
uniprot id: A0A974CLT2
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

8355:sft2d1.S
gene id: 8355:sft2d1.S
uniprot id: A0A1L8G2G3
uniprot id: A0A8J0VGB3
uniprot id: A0A8J1KSZ6
uniprot id: A0A974HH84
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

8355:ets2.S
gene id: 8355:ets2.S
uniprot id: A0A1L8H5C3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus
messages: Transcription factor.

8355:LOC108704046
gene id: 8355:LOC108704046
uniprot id: A0A8J1MYI6
uniprot id: A0A8J1MYJ0
uniprot id: A0A8J1MYS8
uniprot id: A0A8J1MYT2
uniprot id: A0A8J1MYT7
uniprot id: A0A8J1MZN4
uniprot id: A0A8J1MZN8
uniprot id: A0A8J1N0B2
uniprot id: A0A8J1N0B8
uniprot id: A0A8J1N132
uniprot id: A0A8J1N138
names: Similarity
messages: Belongs to the BRAG family.

8355:LOC108695650
gene id: 8355:LOC108695650
uniprot id: A0A1L8HZM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:scn1b.L
gene id: 8355:scn1b.L
uniprot id: A0A1L8FPK6
uniprot id: A0A974CJS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

8355:jmjd6.S
gene id: 8355:jmjd6.S
uniprot id: Q7ZX37
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JMJD6 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as u2af2/u2af65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of u2af2/u2af65, affecting the pre-mRNA splicing activity of u2af2/u2af65. Hydroxylates its own N-terminus, which is required for homooligomerization. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation. Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. In collaboration with brd4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. Demethylates other arginine methylated-proteins such as esr1. Has no histone lysine demethylase activity (By similarity). Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation (By similarity).
messages: Hydroxylates its own N-terminus; hydroxylation is required for homooligomerization.
messages: The nuclear localization signal motifs are necessary and sufficient to target it into the nucleus.
messages: nucleolus
messages: nucleoplasm

8355:lrp5.L
gene id: 8355:lrp5.L
uniprot id: A0A8J1MUB6
uniprot id: A0A8J1MVJ8
uniprot id: Q8AYF1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LDLR family.
messages: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes.
messages: Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108697060
gene id: 8355:LOC108697060
uniprot id: A0A8J1LDJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:ifrd2.L
gene id: 8355:ifrd2.L
uniprot id: A0A8J0UZK6
uniprot id: A0A8J1MVQ0
uniprot id: A0A974D5S1
uniprot id: Q6AZE7
names: Similarity
messages: Belongs to the IFRD family.

8355:ints9.S
gene id: 8355:ints9.S
uniprot id: A0A8J1KRJ0
uniprot id: Q6DFF4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although strongly related to RNA-specific endonuclease proteins, it lacks the HXHXDH motif that binds zinc and participates in the catalytic center. Its function as endonuclease is therefore unsure.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
messages: Belongs to the multiprotein complex Integrator.
messages: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.
messages: Nucleus

8355:rnf168.L
gene id: 8355:rnf168.L
uniprot id: A0A8J0V880
uniprot id: Q6INS5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNF168 family.
messages: E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with ube2n/ubc13 to amplify the rnf8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the rnf8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of tp53bp1 and brca1. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).
messages: Monomer.
messages: Nucleus
messages: The MIU motif (motif interacting with ubiquitin) mediates the interaction with both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains. The UMI motif mediates interaction with ubiquitin with a preference for 'Lys-63'-linked ubiquitin. The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs).

8355:sephs1.S
gene id: 8355:sephs1.S
uniprot id: A0A1L8GZG9
uniprot id: A0A974HTC7
uniprot id: Q6PF47
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selenophosphate synthase 1 family. Class II subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Cell membrane
messages: Homodimer.
messages: Nucleus membrane
messages: Synthesizes selenophosphate from selenide and ATP.
messages: The conserved active site Cys (or selenocysteine) residue in position 29 is replaced by a Thr. However, as function in selenoprotein synthesis is probable, it is possible Cys-31 is the active site.

8355:snrpd2.L
gene id: 8355:snrpd2.L
uniprot id: Q5HZQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

8355:minpp1.S
gene id: 8355:minpp1.S
uniprot id: A0A1L8FE35
uniprot id: A0A974H9K1
names: Similarity
messages: Belongs to the histidine acid phosphatase family. MINPP1 subfamily.

8355:gpatch1.L
gene id: 8355:gpatch1.L
uniprot id: A0A1L8GL60
uniprot id: A0A974D322
names: Similarity
messages: Belongs to the GPATCH1 family.

8355:clcc1.S
gene id: 8355:clcc1.S
uniprot id: A0A8J0V4A0
uniprot id: Q91892
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel MCLC family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Nucleus membrane
messages: Seems to act as a chloride ion channel (By similarity). Plays a role in retina development (By similarity).

8355:LOC108697973
gene id: 8355:LOC108697973
uniprot id: A0A8J0TDS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8355:mis18a.L
gene id: 8355:mis18a.L
uniprot id: A0A1L8HCK9
uniprot id: A0A974DKZ8
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

8355:atg4b.L
gene id: 8355:atg4b.L
uniprot id: A0A8J0V5E1
uniprot id: A0A8J0V997
uniprot id: A0A8J0VE33
uniprot id: Q640G7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. Required for canonical autophagy (macroautophagy), non-canonical autophagy as well as for mitophagy. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3. In addition to the protease activity, also mediates delipidation of ATG8 family proteins. Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy. Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, by catalyzing delipidation of ATG8 proteins conjugated to phosphatidylserine (PS).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Mitochondrion
messages: The LIR motif (LC3-interacting region) is required for the interaction with ATG8 family proteins. Required for proteolytic activation and delipidation of ATG8 proteins.
messages: autophagosome
messages: cytosol

8355:yif1b.S
gene id: 8355:yif1b.S
uniprot id: A0A1L8F3S4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

8355:hyou1.L
gene id: 8355:hyou1.L
uniprot id: A0A1L8FLI2
uniprot id: A0A8J0TB52
uniprot id: A0A974CHW1
names: Similarity
messages: Belongs to the heat shock protein 70 family.

8355:adgrf1.L
gene id: 8355:adgrf1.L
uniprot id: A0A1L8GC24
uniprot id: A0A974CYX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

8355:cdc37l1.L
gene id: 8355:cdc37l1.L
uniprot id: A0A1L8HY65
uniprot id: A0A974DZZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

8355:lyrm2.S
gene id: 8355:lyrm2.S
uniprot id: Q5PQ90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I LYR family.
messages: Involved in effecient integration of the N-module into mitochondrial respiratory chain complex I.
messages: Mitochondrion

8355:rpl23a.L
gene id: 8355:rpl23a.L
uniprot id: A0A1L8H4S4
uniprot id: A0A974HUU2
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

8355:ier2.S
gene id: 8355:ier2.S
uniprot id: D2I901
names: Similarity
messages: Belongs to the IER family.

8355:cnih1.L
gene id: 8355:cnih1.L
uniprot id: A0A8J1LEN4
uniprot id: Q66KH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

8355:sox14.L
gene id: 8355:sox14.L
uniprot id: A0A1L8GB57
uniprot id: A0A974CXA3
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108708413
gene id: 8355:LOC108708413
uniprot id: A0A1L8HGQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus

8355:hmox2.S
gene id: 8355:hmox2.S
uniprot id: Q6GPF6
names: Similarity
messages: Belongs to the heme oxygenase family.

8355:LOC108698757
gene id: 8355:LOC108698757
uniprot id: A0A8J0TC52
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the 40S small ribosomal subunit.

8355:abr.L
gene id: 8355:abr.L
uniprot id: A0A1L8HD47
uniprot id: A0A8J0U3E0
uniprot id: A0A8J0UBJ1
uniprot id: A0A8J1M6X9
uniprot id: A0A974DNK1
uniprot id: Q8AVG0
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form.
messages: Synapse
messages: The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. The C-terminus is a Rho-GAP domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. The protein has a unique structure having two opposing regulatory activities toward small GTP-binding proteins.
messages: axon
messages: dendritic spine

8355:LOC121393140
gene id: 8355:LOC121393140
uniprot id: Q7SZB0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

8355:adra1b.S
gene id: 8355:adra1b.S
uniprot id: A0A8J0UV25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
messages: caveola

8355:trpm8b.L
gene id: 8355:trpm8b.L
uniprot id: A0A1L8EWM8
uniprot id: A0A8J0TQC7
uniprot id: C5IJY8
names: Subcellular Location Annotation
messages: Membrane

8355:ank1.L
gene id: 8355:ank1.L
uniprot id: A0A8J1MMK4
uniprot id: A0A8J1MMK9
uniprot id: A0A8J1MML7
uniprot id: A0A8J1MMN2
uniprot id: A0A8J1MMN8
uniprot id: A0A8J1MMP4
uniprot id: A0A8J1MNJ7
uniprot id: A0A8J1MNJ8
uniprot id: A0A8J1MNK3
uniprot id: A0A8J1MNK4
uniprot id: A0A8J1MNK7
uniprot id: A0A8J1MNL1
uniprot id: A0A8J1MPN5
uniprot id: A0A8J1MPP0
uniprot id: A0A8J1MPP4
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

8355:krt78.4.L
gene id: 8355:krt78.4.L
uniprot id: A0A1L8HIL0
uniprot id: A0A974HZ66
names: Similarity
messages: Belongs to the intermediate filament family.

8355:LOC108708895
gene id: 8355:LOC108708895
uniprot id: A0A8J0UIR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC121401306
gene id: 8355:LOC121401306
uniprot id: A0A8J1MKR1
names: Subcellular Location Annotation
messages: Membrane

8355:fli1b.S
gene id: 8355:fli1b.S
uniprot id: A0A1L8FHN9
uniprot id: A0A8J0TAK2
uniprot id: A1L2Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8355:dcaf12.L
gene id: 8355:dcaf12.L
uniprot id: Q63ZP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat DCAF12 family.
messages: Component of the DCX(DCAF12) E3 ubiquitin ligase complex, at least composed of cul4 (cul4a or cul4b), ddb1, dcaf12 and rbx1.
messages: Cytoplasm
messages: Nucleus
messages: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The DCX(DCAF12) complex specifically recognizes proteins with a diglutamate (Glu-Glu) at the C-terminus leading to their ubiquitination and degradation. Also directly recognizes the C-terminal glutamate-leucine (Glu-Leu) degron as an alternative degron in proteins leading to their ubiquitination and degradation.
messages: centrosome

8355:rbm46.L
gene id: 8355:rbm46.L
uniprot id: A0A1L8HU76
uniprot id: A0A974I3D6
names: Subcellular Location Annotation
messages: Cytoplasm

8355:rab33b.L
gene id: 8355:rab33b.L
uniprot id: A0A1L8HUP7
uniprot id: Q6PCF5
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

8355:LOC108705305
gene id: 8355:LOC108705305
uniprot id: A0A310U9V8
uniprot id: A0A974BQZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

8355:LOC108698867
gene id: 8355:LOC108698867
uniprot id: A0A8J1LFQ0
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8355:LOC121397742
gene id: 8355:LOC121397742
uniprot id: A0A8J1LPA8
uniprot id: A0A8J1LQN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
messages: Belongs to the sulfotransferase 6 family.
messages: Membrane

8355:ndufa13.L
gene id: 8355:ndufa13.L
uniprot id: Q66KN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFA13 subunit family.
messages: Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
messages: Mitochondrion inner membrane

8355:areg.L
gene id: 8355:areg.L
uniprot id: A0A1L8HVB8
uniprot id: A0A974I3R8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:tubb4a.L
gene id: 8355:tubb4a.L
uniprot id: A0A1L8H339
uniprot id: A0A974HU38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

8355:LOC108698977
gene id: 8355:LOC108698977
uniprot id: A0A8J1LI79
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8355:hoxd9.L
gene id: 8355:hoxd9.L
uniprot id: A0A1L8EWC8
uniprot id: A0A974BZI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

8355:f3.S
gene id: 8355:f3.S
uniprot id: A0A8J0V031
uniprot id: A0A8J1N1L5
uniprot id: A0A974D0N5
uniprot id: Q5U482
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.

8355:med20.S
gene id: 8355:med20.S
uniprot id: A0A1L8H6W2
uniprot id: A0A974HVE5
uniprot id: A0A974HVP7
uniprot id: Q6NTV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 20 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8355:cpt2.L
gene id: 8355:cpt2.L
uniprot id: A0A1L8GMF7
uniprot id: A0A974D3S0
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

8355:tm9sf2.S
gene id: 8355:tm9sf2.S
uniprot id: A0A974DID5
uniprot id: Q5U4N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

8355:LOC121399771
gene id: 8355:LOC121399771
uniprot id: A0A8J1M8A4
names: Subcellular Location Annotation
messages: Membrane

8355:krt78.9.L
gene id: 8355:krt78.9.L
uniprot id: A0A1L8HIJ5
uniprot id: A0A974DS93
names: Similarity
messages: Belongs to the intermediate filament family.

8355:vps4b.S
gene id: 8355:vps4b.S
uniprot id: A0A974CLL6
uniprot id: Q8AVB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

8355:LOC108715161
gene id: 8355:LOC108715161
uniprot id: A0A974CZW3
uniprot id: A2BD76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

8355:ppp1cc.L
gene id: 8355:ppp1cc.L
uniprot id: A0A974E1K8
uniprot id: P36874
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cleavage furrow
messages: Cytoplasm
messages: Membrane
messages: Midbody
messages: Mitochondrion
messages: Nucleus
messages: Nucleus speckle
messages: PP1 comprises a catalytic subunit, ppp1c1, ppp1cb or ppp1cc, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then is complexed to one or several targeting or regulatory subunits.
messages: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis (By similarity). Promotes nuclear envelope reassembly by targeting nuclear membrane vesicles to chromatin at the end of mitosis. Acts by dephosphorylating membrane proteins such as lamin B receptor (lbr) to regulate the binding of membrane proteins to chromatin.
messages: kinetochore
messages: nucleolus
messages: nucleoplasm

8355:hoxb9.S
gene id: 8355:hoxb9.S
uniprot id: Q3KQ20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

8355:katnb1.L
gene id: 8355:katnb1.L
uniprot id: A0A1L8GLG1
uniprot id: A0A8J0UST2
uniprot id: A0A974HP31
uniprot id: Q4V7Y7
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat KATNB1 family.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Cytoplasm
messages: Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome.
messages: Interacts with katna1. This interaction enhances the microtubule binding and severing activity of katna1 and also targets this activity to the centrosome.
messages: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

8355:LOC121394151
gene id: 8355:LOC121394151
uniprot id: A0A1L8G0S1
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:LOC108713736
gene id: 8355:LOC108713736
uniprot id: A0A1L8GIG9
uniprot id: A0A974D349
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

8355:LOC121397146
gene id: 8355:LOC121397146
uniprot id: A0A8J1LJL9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

8355:LOC121397326
gene id: 8355:LOC121397326
uniprot id: A0A1L8FBP4
names: Subcellular Location Annotation
messages: Membrane

8355:slc11a1.L
gene id: 8355:slc11a1.L
uniprot id: Q640D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

8355:inha.L
gene id: 8355:inha.L
uniprot id: A9JS55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
messages: Secreted

8355:ppp1r21.L
gene id: 8355:ppp1r21.L
uniprot id: Q6IR70
names: Function
names: Subcellular Location Annotation
messages: Early endosome
messages: Putative regulator of protein phosphatase 1 (PP1) activity. May play a role in the endosomal sorting process or in endosome maturation pathway.

8355:rhbdf1.S
gene id: 8355:rhbdf1.S
uniprot id: A0A1L8EQ44
uniprot id: A0A8J0U0V3
uniprot id: A0A8J0U134
uniprot id: A0A974BVB9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.

8355:stmn1.L
gene id: 8355:stmn1.L
uniprot id: A0A974HXZ8
uniprot id: Q09006
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Accumulates during oogenesis and remains stable as a maternal product throughout early development.
messages: Belongs to the stathmin family.
messages: Binds to two alpha/beta-tubulin heterodimers.
messages: Different phosphorylated forms, from unphosphorylated to highly phosphorylated, are found in the mature egg. Progressive dephosphorylation from the mid-blastula to the tailbud stage.
messages: Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules (By similarity).
messages: Ubiquitous. Mostly abundant in brain and oocytes.
messages: cytoskeleton

8355:cct8.L
gene id: 8355:cct8.L
uniprot id: A0A8J0UAE2
uniprot id: Q7ZTL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: cilium basal body

8355:itga2b.1.S
gene id: 8355:itga2b.1.S
uniprot id: A0A1L8EL13
uniprot id: A0A974BSB8
uniprot id: Q6DCU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

8355:LOC108707626
gene id: 8355:LOC108707626
uniprot id: A0A8J1MCB3
names: Subcellular Location Annotation
messages: Secreted

8355:tnfrsf1a.L
gene id: 8355:tnfrsf1a.L
uniprot id: A0A1L8FIN6
uniprot id: A0A974HB35
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:c1orf52.L
gene id: 8355:c1orf52.L
uniprot id: Q32NA2
names: Similarity
messages: Belongs to the UPF0690 family.

8355:senp3.L
gene id: 8355:senp3.L
uniprot id: Q5XG28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

8355:rplp1.L
gene id: 8355:rplp1.L
uniprot id: A0A974CPY0
uniprot id: Q6P699
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

8355:sptbn1.S
gene id: 8355:sptbn1.S
uniprot id: A0A8J1KSH7
uniprot id: A0A8J1KVI9
names: Similarity
messages: Belongs to the spectrin family.

8355:LOC108697476
gene id: 8355:LOC108697476
uniprot id: A0A1L8FEZ9
uniprot id: A0A8J1LDC6
uniprot id: A0A974CBQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MET18/MMS19 family.
messages: Component of the CIA complex.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus
messages: spindle

8355:tnnt2.L
gene id: 8355:tnnt2.L
uniprot id: A0A8J0UGP9
uniprot id: A0A8J1MB86
uniprot id: Q804V6
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

8355:barx2.L
gene id: 8355:barx2.L
uniprot id: A0A8J0TBL3
names: Subcellular Location Annotation
messages: Nucleus

8355:tgm2.S
gene id: 8355:tgm2.S
uniprot id: A0A8J0TYQ2
uniprot id: Q7SZT2
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

8355:foxi4.2.S
gene id: 8355:foxi4.2.S
uniprot id: A0A974DSE4
uniprot id: Q91904
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expression begins at the early-mid blastula stage. Levels are highest during the blastula and gastrula stages, after which levels decreases until somite segregation. At later developmental stages, expressed at a slightly lower level than foxi1-B.
messages: Induced by Bmp-signaling. Suppressed by Wnt-signaling.
messages: Initially localized to the animal hemisphere (the presumptive ectoderm) of early-mid blastula embryos. Becomes restricted to head placodes, excluding the otic placodes, by the tailbud stages.
messages: Nucleus
messages: Transcription factor. Essential for ventral specification of the early cephalic (head) ectoderm during gastrulation, playing a role in the non-neural versus neural cell fate choice. Binds to DNA via the target sequence 5'-[AG]TAAA[CT]A-3', with 5'-ATAAACA-3' being the preferred binding site.

8355:twf1.L
gene id: 8355:twf1.L
uniprot id: A0A1L8GYS1
uniprot id: A0A974HSR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

8355:foxp2.L
gene id: 8355:foxp2.L
uniprot id: A0A1L8GYY0
uniprot id: A0A8J1MHG1
uniprot id: A0A8J1MHG5
uniprot id: A0A8J1MHG6
uniprot id: A0A8J1MI35
uniprot id: A0A8J1MIF2
uniprot id: A0A974DE03
uniprot id: Q4VYS1
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: At stage 15, expressed in the anterior/superior eye field and the caudal branchial arch. At later stages, expression persists in the retina and in the caudal branchial arch. Expressed in the pronephros and the tip of the tail. Beginning with stage 35, expression in the brain is localized to distinct subdomains of the anterior prosencephalon, the medial mesencephalon and to lateral domains of the hindbrain.
messages: Dimerization is required for DNA-binding.
messages: First expressed weakly at mid-gastrula (stage 11) but expression becomes prominent at stage 15.
messages: Nucleus
messages: The leucine-zipper is required for dimerization and transcriptional repression.
messages: Transcriptional repressor.

8355:slc1a7.L
gene id: 8355:slc1a7.L
uniprot id: A0A1L8GMG0
uniprot id: A0A974D4N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

8355:sult1b1.L
gene id: 8355:sult1b1.L
uniprot id: A0A8J1LP58
uniprot id: A5D8P4
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8355:atg4c.L
gene id: 8355:atg4c.L
uniprot id: A0A1L8GLW8
uniprot id: A0A8J0V1T8
uniprot id: A0A974HNP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

8355:LOC108700598
gene id: 8355:LOC108700598
uniprot id: A0A8J1LN90
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108705708
gene id: 8355:LOC108705708
uniprot id: A0A8J0U7P4
names: Similarity
messages: Belongs to the SKP1 family.

8355:znf703.S
gene id: 8355:znf703.S
uniprot id: Q2VPM4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Elbow/Noc family.
messages: Cytoplasm
messages: Expressed at the posterior ectoderm except for the dorsal midline in gastrulae (PubMed:28716930). During neurulation, expression diminishes so as to become restricted to the lateral neural plate border (NPB) and neural crest (PubMed:28716930).
messages: Morpholino knockdown blocks differentiation of the neural plate border (NPB).
messages: Nucleus
messages: Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation (By similarity). Involved in specification of the lateral neural plate border (NPB) (PubMed:28716930). May be required for segmental gene expression during hindbrain development (By similarity).

8355:LOC108715766
gene id: 8355:LOC108715766
uniprot id: A0A1L8GGZ9
uniprot id: A0A974D150
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

8355:thap1.L
gene id: 8355:thap1.L
uniprot id: A0A974I3Z0
uniprot id: Q5U560
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes (By similarity).
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: nucleoplasm

8355:lipe.S
gene id: 8355:lipe.S
uniprot id: A0A1L8FGV9
uniprot id: A0A8J1LDJ4
uniprot id: A0A8J1LFP3
uniprot id: A0A974CCU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'GDXG' lipolytic enzyme family.
messages: Cell membrane
messages: Lipid droplet
messages: caveola
messages: cytosol

8355:slc13a4.L
gene id: 8355:slc13a4.L
uniprot id: A0A8J1MI51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

8355:scn3b.L
gene id: 8355:scn3b.L
uniprot id: A0A974CFG2
uniprot id: Q6DE47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

8355:ppef2.L
gene id: 8355:ppef2.L
uniprot id: A0A1L8HVE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

8355:bc014685.S
gene id: 8355:bc014685.S
uniprot id: A0A1L8FF36
uniprot id: A0A974CBG8
names: Subcellular Location Annotation
messages: Membrane

8355:tgfa.S
gene id: 8355:tgfa.S
uniprot id: A0A8J0UW25
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108695212
gene id: 8355:LOC108695212
uniprot id: A0A1L8FRT2
uniprot id: A0A974HDU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Membrane

8355:cenpu.L
gene id: 8355:cenpu.L
uniprot id: A0A1L8HU11
uniprot id: A0A8J1MT28
uniprot id: A0A8J1MU50
uniprot id: A0A974DWR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-U/AME1 family.
messages: Nucleus

8355:capn5.L
gene id: 8355:capn5.L
uniprot id: Q7ZWK6
names: Similarity
messages: Belongs to the peptidase C2 family.

8355:kcnj9.L
gene id: 8355:kcnj9.L
uniprot id: A0A1L8FPQ9
uniprot id: A0A974CHU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

8355:nr5a2.S
gene id: 8355:nr5a2.S
uniprot id: A0A8J0UZI0
uniprot id: A0A8J1N080
uniprot id: A0A974D2I2
uniprot id: Q91544
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

8355:lgi2.L
gene id: 8355:lgi2.L
uniprot id: A0A8J1MS23
names: Subcellular Location Annotation
messages: Secreted

8355:rbm47.S
gene id: 8355:rbm47.S
uniprot id: A0A8J1M0U8
uniprot id: A0A8J1M101
uniprot id: A0A8J1M2V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM RBM47 family.
messages: Cytoplasm
messages: Nucleus

8355:LOC108703980
gene id: 8355:LOC108703980
uniprot id: A0A8J0TVS5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC121394616
gene id: 8355:LOC121394616
uniprot id: A0A8J1KZ24
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:atp5f1a.L
gene id: 8355:atp5f1a.L
uniprot id: A0A974I5F3
uniprot id: Q68EY5
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

8355:srp68.L
gene id: 8355:srp68.L
uniprot id: A0A974H2Y2
uniprot id: A6H8I5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
messages: Cytoplasm
messages: nucleolus

8355:XB5900382.L
gene id: 8355:XB5900382.L
uniprot id: A0A1L8I396
uniprot id: A0A974E398
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8355:cnn1.S
gene id: 8355:cnn1.S
uniprot id: Q6PAB2
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

8355:rad21.L
gene id: 8355:rad21.L
uniprot id: O93310
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity).
messages: Belongs to the rad21 family.
messages: Chromosome
messages: Cleaved by separase/ESPL1 at the onset of anaphase; this cleavage is required for sister chromatid separation and cytokinesis (By similarity). Cleaved by caspases at the beginning of apoptosis (By similarity).
messages: Component of the cohesin complex, which consists of an SMC1 and SMC3 heterodimer core and 2 non-Smc subunits RAD21 and STAG1/SA1, STAG2/SA2 or STAG3/SA3.
messages: May promote apoptosis.
messages: Nucleus
messages: Nucleus matrix
messages: Phosphorylated; becomes hyperphosphorylated in M phase of cell cycle. The large dissociation of cohesin from chromosome arms during prophase may be partly due to phosphorylation by PLK1/PLX1.
messages: The C-terminal part associates with the head of smc1a, while the N-terminal part binds to the head of smc3.
messages: centromere
messages: cytosol
messages: spindle pole

8355:lif.S
gene id: 8355:lif.S
uniprot id: A0A1L8HPW4
uniprot id: A0A8J0U9U0
names: Function
messages: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.

8355:LOC121395252
gene id: 8355:LOC121395252
uniprot id: A0A8J1L3W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8355:ssr1.S
gene id: 8355:ssr1.S
uniprot id: A0A1L8FS90
uniprot id: A0A974CJ91
uniprot id: A0A974CJV3
uniprot id: Q6DCM6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

8355:LOC108711822
gene id: 8355:LOC108711822
uniprot id: A0A8J0ULU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:cav1.S
gene id: 8355:cav1.S
uniprot id: A0A8J1MQ12
uniprot id: A0A974D8V5
uniprot id: Q6P7G5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

8355:ddo.L
gene id: 8355:ddo.L
uniprot id: A0A1L8G961
uniprot id: A0A8J1KNN3
uniprot id: A0A974CXD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

8355:LOC108716290
gene id: 8355:LOC108716290
uniprot id: A0A8J1KS51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCARA5 family.
messages: Cell membrane
messages: Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways.
messages: Homotrimer.
messages: Membrane

8355:LOC121394545
gene id: 8355:LOC121394545
uniprot id: A0A8J1KX40
uniprot id: A0A8J1L016
uniprot id: A0A8J1L061
names: Subcellular Location Annotation
messages: Membrane

8355:efs.L
gene id: 8355:efs.L
uniprot id: A0A8J0UHD5
uniprot id: A0A8J0UIL6
uniprot id: A0A8J0ULG6
uniprot id: Q5XG33
names: Similarity
messages: Belongs to the CAS family.

8355:LOC121402037
gene id: 8355:LOC121402037
uniprot id: A0A8J1MRP7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:lhx3.L
gene id: 8355:lhx3.L
uniprot id: A0A8J0TEC2
uniprot id: A0A8J0THU5
uniprot id: B7ZPU9
uniprot id: P36200
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: First detectable at the neural plate stage in the stomodeal-hypophyseal (pituitary) anlage and in the neural plate. At later stages it persists in the pituitary and pineal, retina, hindbrain and spinal cord.
messages: In dorsal regions at neural tube and tailbud stages and in adults predominantly in the pituitary gland and weakly in the eye and brain.
messages: Interacts with ldb1 and with the N-terminus of rnf12.
messages: Nucleus
messages: Transcription factor (By similarity). May be involved in the specification and maintenance of differentiation of distinct neuronal and neuroendocrine tissues. Early marker for the pituitary and pineal lineages, it may be involved in specifying these lineages.

8355:LOC108698790
gene id: 8355:LOC108698790
uniprot id: A0A1L8FA10
uniprot id: A0A974H8L6
names: Similarity
messages: Belongs to the SEC6 family.

8355:spns2.L
gene id: 8355:spns2.L
uniprot id: A0A8J1MAW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8355:cabin1.L
gene id: 8355:cabin1.L
uniprot id: A0A1L8I0F0
uniprot id: A0A8J0V533
uniprot id: A0A8J0V8B2
uniprot id: A0A8J0V906
uniprot id: A0A8J0VDT4
uniprot id: A0A974E214
names: Subcellular Location Annotation
messages: Nucleus

8355:npc1l1.S
gene id: 8355:npc1l1.S
uniprot id: A0A1L8GRV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

8355:LOC121399020
gene id: 8355:LOC121399020
uniprot id: A0A8J1M163
names: Subcellular Location Annotation
messages: Membrane

8355:XB5863395.L
gene id: 8355:XB5863395.L
uniprot id: A0A974CPP4
uniprot id: Q6GLX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RGS7BP/RGS9BP family.
messages: Membrane
messages: Regulator of G protein-coupled receptor (GPCR) signaling. Probably acts by regulating the activity of some 'R7' family protein (RGS6, RGS7, RGS9 and/or RGS11).

8355:taok1.L
gene id: 8355:taok1.L
uniprot id: Q6NU21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: Serine/threonine-protein kinase involved in various processes such as p38/mapk14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of upstream MAP kinase kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade (By similarity).

8355:LOC121399776
gene id: 8355:LOC121399776
uniprot id: A0A8J1M6F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:xcxcra
gene id: 8355:xcxcra
uniprot id: A0A974CD76
uniprot id: K7ZLW8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:foxi2.S
gene id: 8355:foxi2.S
uniprot id: Q5NDM2
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed both maternally and zygotically. Maternal levels decrease rapidly during the early cleavage stages. Zygotic expression begins at neurulation.
messages: Localized to the animal hemisphere of early cleavage stage embryos. Zygotic expression is restricted to the dorsal part of the epibranchial placodes of the head within a region located near the tip of the first, second and third visceral pouch.
messages: Nucleus
messages: Possible transcriptional activator.

8355:plxnb1.S
gene id: 8355:plxnb1.S
uniprot id: A0A1L8GHW9
uniprot id: A0A974HME4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

8355:snx6.L
gene id: 8355:snx6.L
uniprot id: A0A8J0TIE0
uniprot id: Q6DE29
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

8355:adcy1.S
gene id: 8355:adcy1.S
uniprot id: A0A8J1L1W1
uniprot id: A0A8J1L3F3
uniprot id: A0A8J1L4K1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

8355:npy.L
gene id: 8355:npy.L
uniprot id: P33689
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
messages: Secreted
messages: neuronal dense core vesicle

8355:ppa2.L
gene id: 8355:ppa2.L
uniprot id: Q6GN00
names: Similarity
messages: Belongs to the PPase family.

8355:LOC108703549
gene id: 8355:LOC108703549
uniprot id: A0A8J1MV56
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

8355:gadd45b.L
gene id: 8355:gadd45b.L
uniprot id: A0A8J0UV54
names: Similarity
messages: Belongs to the GADD45 family.

8355:LOC108701945
gene id: 8355:LOC108701945
uniprot id: A0A1L8EZ65
uniprot id: A0A974C195
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:ppp1r15b-b
gene id: 8355:ppp1r15b-b
uniprot id: Q5U4R3
names: Similarity
messages: Belongs to the PPP1R15 family.

8355:h2ac14.L
gene id: 8355:h2ac14.L
uniprot id: A0A974BPE8
uniprot id: Q6AZJ8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:cry-dash.L
gene id: 8355:cry-dash.L
uniprot id: Q75WS4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.
messages: Binds 1 FAD per subunit.
messages: May have a photoreceptor function (By similarity). Has weak cyclobutyl pyrimidine photolyase activity when expressed in E.coli and when tested in vitro.

8355:serpine1.L
gene id: 8355:serpine1.L
uniprot id: A0A8J1MIM1
uniprot id: Q0IHE4
names: Similarity
messages: Belongs to the serpin family.

8355:copz1.S
gene id: 8355:copz1.S
uniprot id: A0AUT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

8355:dhx8.S
gene id: 8355:dhx8.S
uniprot id: A0A8J1LZR9
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC447781
gene id: 8355:LOC447781
uniprot id: A0A1L8F431
uniprot id: A0A1L8F445
uniprot id: A0A974C4F9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

8355:slc25a1-b
gene id: 8355:slc25a1-b
uniprot id: A0A8J0Q7F3
uniprot id: A5D8Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8355:LOC121401228
gene id: 8355:LOC121401228
uniprot id: A0A8J1MIB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8355:dnajc16.S
gene id: 8355:dnajc16.S
uniprot id: A0A1L8FHP4
uniprot id: A0A974CDW9
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays an important role in regulating the size of autophagosomes during the formation process.

8355:ier3ip1.L
gene id: 8355:ier3ip1.L
uniprot id: A0A974E4G3
uniprot id: Q3B8G7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YOS1 family.
messages: Endoplasmic reticulum membrane
messages: Regulator of endoplasmic reticulum secretion that acts as a key determinant of brain size. Required for secretion of extracellular matrix proteins. Required for correct brain development by depositing sufficient extracellular matrix proteins for tissue integrity and the proliferation of neural progenitors (By similarity). Acts as a regulator of the unfolded protein response (UPR) (By similarity).

8355:plk2.S
gene id: 8355:plk2.S
uniprot id: Q7ZX26
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

8355:LOC108697876
gene id: 8355:LOC108697876
uniprot id: A0A1L8FHN0
uniprot id: A0A8J1LE22
uniprot id: A0A974CD95
names: Similarity
messages: Belongs to the CAMK2N family.

8355:c1qbp.L
gene id: 8355:c1qbp.L
uniprot id: A0A1L8HGG4
uniprot id: A0A974HYU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAM33 family.
messages: Cell membrane

8355:ppm1e.S
gene id: 8355:ppm1e.S
uniprot id: A0A1L8H8C2
uniprot id: A0A974DK80
names: Similarity
messages: Belongs to the PP2C family.

8355:tmeff2.L
gene id: 8355:tmeff2.L
uniprot id: A0A1L8EXD0
uniprot id: A0A8J0TUV2
uniprot id: A0A974BZX2
uniprot id: A0A974BZZ6
uniprot id: Q0IHG2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:tmem192.L
gene id: 8355:tmem192.L
uniprot id: Q66KF2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM192 family.
messages: Homodimer.
messages: Late endosome
messages: Lysosome membrane

8355:slc25a37.S
gene id: 8355:slc25a37.S
uniprot id: A0A1L8GRS8
uniprot id: A0A974HQB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8355:MGC147226.S
gene id: 8355:MGC147226.S
uniprot id: A0A1L8GHZ2
uniprot id: A0A974D0P7
uniprot id: B1H1Q7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

8355:grina.L
gene id: 8355:grina.L
uniprot id: A0A974CQF6
uniprot id: Q8AVK4
names: Subcellular Location Annotation
messages: Membrane

8355:LOC121393773
gene id: 8355:LOC121393773
uniprot id: A0A8J1KPB5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

8355:LOC108701773
gene id: 8355:LOC108701773
uniprot id: A0A8J1LU14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

8355:spo11.L
gene id: 8355:spo11.L
uniprot id: A0A1L8ESW0
uniprot id: A0A8J1LUQ7
names: Similarity
messages: Belongs to the TOP6A family.

8355:slc25a29.L
gene id: 8355:slc25a29.L
uniprot id: A0A1L8FA24
uniprot id: A0A974H869
uniprot id: Q66KI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8355:crygdl.18.L
gene id: 8355:crygdl.18.L
uniprot id: A0A8J1MIN0
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:mmp9.2.L
gene id: 8355:mmp9.2.L
uniprot id: A1ILK1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: extracellular matrix

8355:clic1.L
gene id: 8355:clic1.L
uniprot id: A0A974C7F0
uniprot id: Q6GP73
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane
messages: Nucleus membrane

8355:LOC108705439
gene id: 8355:LOC108705439
uniprot id: A0A8J0U6X7
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

8355:cd28.L
gene id: 8355:cd28.L
uniprot id: A1L2W1
names: Subcellular Location Annotation
messages: Membrane

8355:LOC121396948
gene id: 8355:LOC121396948
uniprot id: A0A8J1LHK3
names: Similarity
messages: Belongs to the SUA5 family.

8355:elac1.L
gene id: 8355:elac1.L
uniprot id: A0A8J0VFG0
names: Subunit
messages: Homodimer.

8355:actb.S
gene id: 8355:actb.S
uniprot id: A0A974C008
uniprot id: O93400
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.
messages: Belongs to the actin family.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylation at His-73 by SETD3. Methylation stabilizes actin filaments.
messages: N-terminal cleavage of acetylated methionine of immature cytoplasmic actin by ACTMAP.
messages: Nucleus
messages: Oxidation of Met-44 and Met-47 by MICALs (mical1, mical2 or mical3) to form methionine sulfoxide promotes actin filament depolymerization. Mical1 and mical2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by msrb1 and msrb2, which promote actin repolymerization.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix (By similarity). Each actin can bind to 4 others (By similarity).
messages: cytoskeleton

8355:usp3.S
gene id: 8355:usp3.S
uniprot id: A0A1L8GTD1
uniprot id: A0A8J0UVY8
uniprot id: A0A974D8F4
names: Similarity
messages: Belongs to the peptidase C19 family.

8355:foxn4.L
gene id: 8355:foxn4.L
uniprot id: A0A1L8I009
uniprot id: A0A974I580
names: Subcellular Location Annotation
messages: Nucleus

8355:ankrd13b.L
gene id: 8355:ankrd13b.L
uniprot id: A0A1L8HD40
uniprot id: A0A8J1M7G9
uniprot id: A0A8J1M8E9
uniprot id: A0A8J1M977
uniprot id: A0A974DLB0
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

8355:tsr3.L
gene id: 8355:tsr3.L
uniprot id: A0A1L8EXU5
uniprot id: A0A974H441
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:adcyap1r1.L
gene id: 8355:adcyap1r1.L
uniprot id: A0A8J1KWL1
uniprot id: A0A8J1KWL7
uniprot id: A0A8J1KWM2
uniprot id: A0A8J1KZJ2
names: Subcellular Location Annotation
messages: Membrane

8355:pabir3.S
gene id: 8355:pabir3.S
uniprot id: A0A1L8F3D9
uniprot id: A0A8J0TH50
uniprot id: A0A8J0TPU7
uniprot id: A0A8J0TQU2
uniprot id: A0A8J0TRW0
uniprot id: A0A8J1LPI5
uniprot id: A0A974C3X0
names: Similarity
messages: Belongs to the FAM122 family.

8355:LOC108705000
gene id: 8355:LOC108705000
uniprot id: A0A8J1M2G2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:fam168a.S
gene id: 8355:fam168a.S
uniprot id: A0A974HXB1
uniprot id: Q66IP6
names: Similarity
messages: Belongs to the FAM168 family.

8355:LOC108695921
gene id: 8355:LOC108695921
uniprot id: A0A8J1L7T4
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8355:gipr.S
gene id: 8355:gipr.S
uniprot id: A0A8J1LPM6
names: Subcellular Location Annotation
messages: Membrane

8355:tpm3.L
gene id: 8355:tpm3.L
uniprot id: A0A8J0TKC0
uniprot id: A0A8J0TLS1
uniprot id: A0A8J0TML9
uniprot id: A0A8J1LJG4
uniprot id: A0A8J1LJH0
uniprot id: A0A8J1LJN5
uniprot id: A0A8J1LKC3
uniprot id: A0A8J1LKC9
uniprot id: A0A8J1LKT8
uniprot id: A0A8J1LLY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

8355:rhbdl2.L
gene id: 8355:rhbdl2.L
uniprot id: A0A1L8HE37
uniprot id: A0A974HXT0
uniprot id: Q5XGS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Membrane

8355:gata6.S
gene id: 8355:gata6.S
uniprot id: A0A8J0VPS7
uniprot id: A0A974CL83
uniprot id: Q91678
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expression is up-regulated during gastrulation.
messages: In embryos, expressed in the presumptive heart mesoderm. In adults, expressed at high levels in heart, small intestine, and stomach and at lower levels in lung, pancreas and colon.
messages: Nucleus
messages: Transcriptional activator that binds 5'-GATA-3'-containing motifs within gene promoters (By similarity). Regulates cardiac-specific transcription during embryogenesis and thereby cardiogenesis.

8355:tax1bp3.S
gene id: 8355:tax1bp3.S
uniprot id: A0A974DGE4
uniprot id: Q6DKL6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.
messages: Nucleus

8355:gem.L
gene id: 8355:gem.L
uniprot id: A0A1L8FZH7
uniprot id: A0A974CQX2
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

8355:abl2.L
gene id: 8355:abl2.L
uniprot id: A0A8J1MVW5
uniprot id: Q6P282
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

8355:rffl.L
gene id: 8355:rffl.L
uniprot id: A0A1L8HG40
uniprot id: A0A8J0UCC9
uniprot id: A0A974DN82
uniprot id: Q68EY6
names: Subcellular Location Annotation
messages: Cell membrane

8355:tmcc2.L
gene id: 8355:tmcc2.L
uniprot id: A0A1L8HER4
uniprot id: A0A8J1M890
uniprot id: A0A8J1MA26
uniprot id: A0A974DP55
names: Similarity
messages: Belongs to the TEX28 family.

8355:polr2a.S
gene id: 8355:polr2a.S
uniprot id: A0A8J0U2K7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

8355:slc25a44.S
gene id: 8355:slc25a44.S
uniprot id: A0A1L8F4U9
uniprot id: Q6DFD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8355:foxc1.S
gene id: 8355:foxc1.S
uniprot id: A0A974CKD0
uniprot id: Q9PVZ3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: By vegt, acting via nodal signaling.
messages: DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Required for cell viability and resistance to oxidative stress in the eye. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals. Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion. Involved in chemokine-induced endothelial cell migration. Plays a role in epidermal keratinocyte terminal differentiation. Essential developmental transcriptional factor required for mesoderm-derived tissues formation, such as the somites, skin, bone and cartilage. Plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner (By similarity). Plays a role at the gastrula stage for expression of several mesodermal and endodermal genes (PubMed:17705306). At the late neurula stage, regulates expression of adhesion genes to maintain cell adhesion in the mesodermal germ layer (PubMed:17705306).
messages: Embryos gastrulate and neurulate, but at the tailbud stage show stunted growth and loss of cells at the blastopore. Embryos continue to develop but display shortened axes and abnormal gut and heart development by the swimming tadpole stage.
messages: Expressed from late blastula/early gastrula stage throughout embryogenesis.
messages: In gastrulae, expressed in ventral and lateral but not dorsal mesoderm. In neurulae, expressed in the posterior mesoderm except for the dorsal midline, and also at the lateral border of the neural plate and within anterior neuroectoderm. From tailbud stages, expressed in the pronephros, heart, neural crest cells surrounding the eye, in the mandibular, hyoid and branchial arches, and within the tail.
messages: Monomer.
messages: Nucleus

8355:zyx.S
gene id: 8355:zyx.S
uniprot id: A5H447
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adhesion plaque protein. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). Suppresses the transcription-repressing activity of hesx1/anf1.
messages: At the early gastrula stage, expressed at a low level in the animal hemisphere. Expression rises by the end of gastrulation in the anterior part of the embryo, where it gradually increases by the midneurula stage. During neurulation, expression continues most intensively in the anterior part of the neural plate and around it. At later stages, intensely expressed in the brain and at lower levels in the spinal cord, eyes, nasal placodes, within somites, and around the cement gland.
messages: Belongs to the zyxin/ajuba family.
messages: Cytoplasm
messages: Expressed at a low level at early stages. Expression increases during gastrulation, reaches maximum levels by the middle of neurulation, and slightly decreases during later development.
messages: Interacts (via LIM2 domain) with hesx1/anf1.
messages: cytoskeleton
messages: focal adhesion

8355:cd44.L
gene id: 8355:cd44.L
uniprot id: A0A8J0UT55
uniprot id: A0A8J0UY46
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: microvillus

8355:kcnmb4.S
gene id: 8355:kcnmb4.S
uniprot id: A0A1L8GUG4
uniprot id: A0A974HRC7
names: Subcellular Location Annotation
messages: Membrane

8355:nkx6-3.S
gene id: 8355:nkx6-3.S
uniprot id: A0A1L8GRQ7
uniprot id: A0A974D6N4
names: Subcellular Location Annotation
messages: Nucleus

8355:psma7.L
gene id: 8355:psma7.L
uniprot id: A0A974BXP5
uniprot id: Q9PVY6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated in G2 phase.
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

8355:LOC121400779
gene id: 8355:LOC121400779
uniprot id: A0A8J1MHV5
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:pfdn4.S
gene id: 8355:pfdn4.S
uniprot id: A0A1L8ELI6
uniprot id: A0A974H0P7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

8355:tspan3.L
gene id: 8355:tspan3.L
uniprot id: A0A974DE86
uniprot id: Q4FZN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8355:ak4.S
gene id: 8355:ak4.S
uniprot id: A0A1L8GFP7
uniprot id: A0A8J0V6P6
uniprot id: A0A974HLU3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion matrix
messages: Monomer.

8355:dpy19l1.L
gene id: 8355:dpy19l1.L
uniprot id: A0A1L8HV41
uniprot id: A0A974DYK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

8355:LOC108716798
gene id: 8355:LOC108716798
uniprot id: A0A1L8G949
uniprot id: A0A974CX28
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

8355:ctsf.L
gene id: 8355:ctsf.L
uniprot id: A0A1L8GK32
uniprot id: A0A974D259
names: Similarity
messages: Belongs to the peptidase C1 family.

8355:notch2.S
gene id: 8355:notch2.S
uniprot id: A0A1L8GGU0
uniprot id: A0A974D2Q4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

8355:LOC121398019
gene id: 8355:LOC121398019
uniprot id: A0A1L8EVP4
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:pggt1b.S
gene id: 8355:pggt1b.S
uniprot id: Q4QQZ0
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

8355:LOC108697259
gene id: 8355:LOC108697259
uniprot id: A0A8J1LD89
uniprot id: A0A8J1LDL1
uniprot id: A0A8J1LET3
uniprot id: A0A8J1LFQ8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Postsynaptic density

8355:nelfcd.L
gene id: 8355:nelfcd.L
uniprot id: A0A1L8ET09
uniprot id: A0A974BX68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NELF-D family.
messages: Nucleus

8355:chrm1.S
gene id: 8355:chrm1.S
uniprot id: A0A1L8GDD8
uniprot id: A0A974CZY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

8355:srp68.S
gene id: 8355:srp68.S
uniprot id: A0A1L8EMX9
uniprot id: A0A974BTV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
messages: Cytoplasm
messages: nucleolus

8355:LOC108701939
gene id: 8355:LOC108701939
uniprot id: A0A8J0TY39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:fam20b.L
gene id: 8355:fam20b.L
uniprot id: A0A1L8GMN6
uniprot id: A0A974D5R6
uniprot id: Q6GQL4
names: Similarity
messages: Belongs to the FAM20 family.

8355:kremen2.S
gene id: 8355:kremen2.S
uniprot id: A0A8J1LVU9
uniprot id: Q8AXX3
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.

8355:lrp3.S
gene id: 8355:lrp3.S
uniprot id: A0A8J0U3U3
uniprot id: A0A8J1KIH2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:ube2b.S
gene id: 8355:ube2b.S
uniprot id: A0A974HQ91
uniprot id: Q6GR64
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8355:LOC108714237
gene id: 8355:LOC108714237
uniprot id: A0A1L8GLX4
uniprot id: A0A8J0V277
uniprot id: A0A8J1MWU5
uniprot id: A0A8J1MY08
uniprot id: A0A8J1MYI8
uniprot id: A0A8J1MYJ3
uniprot id: A0A8J1MZB6
uniprot id: A0A974D619
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

8355:gadd45g.S
gene id: 8355:gadd45g.S
uniprot id: Q7ZXC4
names: Similarity
messages: Belongs to the GADD45 family.

8355:tmprss4.L
gene id: 8355:tmprss4.L
uniprot id: A0A1L8FLP3
uniprot id: A0A974CHW7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:pcnx4.L
gene id: 8355:pcnx4.L
uniprot id: Q5HZQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

8355:man1a2.L
gene id: 8355:man1a2.L
uniprot id: A0A974DMR7
uniprot id: Q6DFL1
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

8355:LOC108700178
gene id: 8355:LOC108700178
uniprot id: A0A8J0TPU2
uniprot id: A0A8J0TQT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

8355:LOC108717043
gene id: 8355:LOC108717043
uniprot id: A0A8J0VHH0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:s1pr4.L
gene id: 8355:s1pr4.L
uniprot id: A0A1L8HXJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108700297
gene id: 8355:LOC108700297
uniprot id: A0A1L8F454
uniprot id: A0A974H677
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB11 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane

8355:LOC121401277
gene id: 8355:LOC121401277
uniprot id: A0A8J1MJ76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:pou5f3.3.S
gene id: 8355:pou5f3.3.S
uniprot id: A0A1L8F0S8
uniprot id: A0A974C241
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

8355:LOC108698326
gene id: 8355:LOC108698326
uniprot id: A0A1L8F6Z9
uniprot id: A0A8J0TJW8
uniprot id: A0A974C6E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8355:nmt2.S
gene id: 8355:nmt2.S
uniprot id: A0A1L8FQW5
uniprot id: A0A974HDJ5
names: Function
names: Similarity
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.

8355:rell2.L
gene id: 8355:rell2.L
uniprot id: A0A1L8GX57
uniprot id: A0A8J0UMG5
uniprot id: A0A974HSH3
uniprot id: Q68EV2
names: Similarity
messages: Belongs to the RELT family.

8355:fzd9.S
gene id: 8355:fzd9.S
uniprot id: A0A1L8H5V1
uniprot id: A0A974DI29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Membrane

8355:abca4.L
gene id: 8355:abca4.L
uniprot id: A0A8J1MWF7
uniprot id: Q5F1L3
names: Subcellular Location Annotation
messages: Membrane

8355:LOC121399706
gene id: 8355:LOC121399706
uniprot id: A0A1L8HDZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:sugp1.L
gene id: 8355:sugp1.L
uniprot id: A0A8J0UTN5
names: Subcellular Location Annotation
messages: Nucleus

8355:macir.S
gene id: 8355:macir.S
uniprot id: A0A1L8HR46
uniprot id: A0A974I234
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UNC119-binding protein family.
messages: Cytoplasm
messages: cilium

8355:slc16a3.S
gene id: 8355:slc16a3.S
uniprot id: A0A8J0U4N0
uniprot id: Q7ZXP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

8355:taf7.L
gene id: 8355:taf7.L
uniprot id: A0A1L8F6P5
uniprot id: A0A974C685
uniprot id: A0A974C6C9
uniprot id: Q6DEC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

8355:osbpl8.L
gene id: 8355:osbpl8.L
uniprot id: A0A1L8GYP0
uniprot id: A0A8J1MKK2
uniprot id: A0A8J1MLK1
uniprot id: A0A8J1MMM0
uniprot id: A0A974DDL3
names: Similarity
messages: Belongs to the OSBP family.

8355:LOC108695629
gene id: 8355:LOC108695629
uniprot id: A0A1L8HZD4
uniprot id: A0A974I583
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:cryga.7.S
gene id: 8355:cryga.7.S
uniprot id: A0A8J1LX07
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:me2.S
gene id: 8355:me2.S
uniprot id: A0A1L8HRZ7
uniprot id: A0A1L8HS05
uniprot id: A0A8J0TJR1
uniprot id: A0A8J0TTE9
uniprot id: A0A974DVE5
uniprot id: A0A974DWL8
uniprot id: Q5XH25
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

8355:kcnh5.L
gene id: 8355:kcnh5.L
uniprot id: A0A1L8FA96
uniprot id: A0A8J0TCF4
uniprot id: A0A8J0TK80
uniprot id: A0A8J0TL11
uniprot id: A0A8J0TM05
uniprot id: A0A974C8X9
names: Subcellular Location Annotation
messages: Membrane

8355:lxn.S
gene id: 8355:lxn.S
uniprot id: A0A1L8G444
uniprot id: A0A974CS35
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

8355:LOC108710588
gene id: 8355:LOC108710588
uniprot id: A0A1L8GYN3
uniprot id: A0A974HT04
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:nos1.L
gene id: 8355:nos1.L
uniprot id: A0A1L8I1A8
uniprot id: A0A8J1MNE2
uniprot id: B7ZRI9
uniprot id: Q800E5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.
messages: dendritic spine
messages: sarcolemma

8355:zranb2.L
gene id: 8355:zranb2.L
uniprot id: A0A8J0UTK0
uniprot id: Q5XGW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZRANB2 family.
messages: May interfere with constitutive 5'-splice site selection.
messages: Nucleus

8355:septin6.L
gene id: 8355:septin6.L
uniprot id: A0A1L8F7P1
uniprot id: A0A8J0T8Z6
uniprot id: A0A8J0THM8
uniprot id: A0A974C6Z1
uniprot id: Q6DCR0
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

8355:abca5.S
gene id: 8355:abca5.S
uniprot id: A0A1L8EKD4
uniprot id: A0A8J0TR93
uniprot id: A0A8J1LXX3
uniprot id: A0A974BS47
names: Subcellular Location Annotation
messages: Membrane

8355:LOC121399777
gene id: 8355:LOC121399777
uniprot id: A0A8J1M6G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:rhot1.S
gene id: 8355:rhot1.S
uniprot id: A0A8J1M062
uniprot id: A0A8J1M084
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrion outer membrane

8355:LOC108699229
gene id: 8355:LOC108699229
uniprot id: A0A8J0TL27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8355:mycbp2.L
gene id: 8355:mycbp2.L
uniprot id: A0A8J0U822
uniprot id: A0A8J0UEU7
uniprot id: A0A8J0UG50
uniprot id: A0A8J0UGC5
uniprot id: A0A8J0UIW1
uniprot id: A0A8J1M9I7
uniprot id: A0A8J1M9I9
uniprot id: A0A8J1M9J3
uniprot id: A0A8J1M9J5
uniprot id: A0A8J1M9T6
uniprot id: A0A8J1M9U1
uniprot id: A0A8J1MAJ6
uniprot id: A0A8J1MAK2
uniprot id: A0A8J1MBC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RING-Cys relay (RCR) family.
messages: axon

8355:glyr1.L
gene id: 8355:glyr1.L
uniprot id: A0A1L8EYV2
uniprot id: A0A8J0TP69
uniprot id: A0A8J0TWM6
uniprot id: A0A8J0TXS2
uniprot id: A0A8J0TZA9
uniprot id: A0A974C0U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HIBADH-related family. NP60 subfamily.
messages: Chromosome

8355:LOC495139
gene id: 8355:LOC495139
uniprot id: A0A974CB52
uniprot id: Q5XGU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

8355:LOC108715864
gene id: 8355:LOC108715864
uniprot id: A0A8J0VCP4
uniprot id: A0A8J1KK03
names: Subcellular Location Annotation
messages: cytoskeleton

8355:slc2a15a.L
gene id: 8355:slc2a15a.L
uniprot id: A0A1L8HTC5
uniprot id: A0A8J0THR9
uniprot id: A0A8J1MR14
uniprot id: A0A974I2M0
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

8355:ednrb.S
gene id: 8355:ednrb.S
uniprot id: A0A1L8H972
uniprot id: A0A974HWF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:fgfbp2.L
gene id: 8355:fgfbp2.L
uniprot id: A0A1L8HTI9
uniprot id: A0A974DXJ7
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

8355:nsg1.L
gene id: 8355:nsg1.L
uniprot id: A0A1L8HTC1
uniprot id: A0A974DXH8
names: Similarity
messages: Belongs to the NSG family.

8355:nkx2-8.L
gene id: 8355:nkx2-8.L
uniprot id: A0A1L8FAM8
uniprot id: A0A974C8I2
names: Subcellular Location Annotation
messages: Nucleus

8355:chrm5.S
gene id: 8355:chrm5.S
uniprot id: A0A1L8EZM2
uniprot id: A0A974H4R2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

8355:tph2.S
gene id: 8355:tph2.S
uniprot id: A0A1L8GUD7
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

8355:nr1i3.S
gene id: 8355:nr1i3.S
uniprot id: A0A8J1LMP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

8355:LOC108716418
gene id: 8355:LOC108716418
uniprot id: A0A8J0VET4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:pax7.S
gene id: 8355:pax7.S
uniprot id: A0A1L8FHK8
uniprot id: A0A8J0TFH7
uniprot id: A0A974CDP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

8355:LOC121399750
gene id: 8355:LOC121399750
uniprot id: A0A8J1M6D5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC121401264
gene id: 8355:LOC121401264
uniprot id: A0A8J1MJ61
names: Subcellular Location Annotation
messages: Membrane

8355:nts.S
gene id: 8355:nts.S
uniprot id: A0A974HR74
uniprot id: Q6GM28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurotensin family.
messages: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
messages: Secreted
messages: Vesicle
messages: secretory vesicle

8355:nr6a1.S
gene id: 8355:nr6a1.S
uniprot id: A0A8J0TEN7
uniprot id: A0A8J0TMG4
uniprot id: A0A8J1LLR3
uniprot id: P70033
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family.
messages: Belongs to the nuclear hormone receptor family. NR6 subfamily.
messages: By retinoic acid.
messages: Cytoplasm
messages: Embryonic form.
messages: Homodimer.
messages: Isoform Oo is expressed both maternally and zygotically, being predominantly expressed in oocytes and embryos before the midblastula transition but present at later stages at very low levels. Isoform Em is expressed zygotically between late gastrula stage and late tailbud stage 30, being predominant during tailbud stages.
messages: Nucleus
messages: Oocyte form.
messages: Probable orphan nuclear receptor. Binds to a response element containing repeats of the motif 5'-AGGTCA-3'. Required for anterior-posterior patterning during organogenesis. Acts with chordin to play a role in patterning the midbrain-hindbrain. Isoform Em is required for integrin-mediated cell matrix interaction during neurulation and for the morphogenetic movements leading to formation of the neural tube. Also mediates the effect of retinoic acid on primary neurogenesis.
messages: Transiently expressed in differentiating cells of all embryonic germ layers. Expressed in an anterior to posterior concentration gradient from late gastrula to midneurula stages. Shows a complicated spatio-temporal pattern of expression during neurulation, being predominant in the neural plate and neural crest in midneurula embryos. At late tailbud (stage 30), mainly expressed in the head mesenchyme, gill arches and tail tip. Expression persists in the epidermis, somites and endoderm, and in the central nervous system, expression is restricted to the midbrain, hindbrain and part of the spinal cord. Isoforms Oo and Em are both expressed in the brain and isoform Oo is expressed in the germ cells of both the adult testis and ovary.

8355:cryga.1.L
gene id: 8355:cryga.1.L
uniprot id: A0A974BZX3
uniprot id: Q6DKC9
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:tubb2b.S
gene id: 8355:tubb2b.S
uniprot id: A0A974CJV7
uniprot id: P13602
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Nervous system specific.
messages: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity).
messages: Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. The precise function of polyglycylation is still unclear.
messages: The MREI motif is common among all beta-tubulin isoforms and may be critical for tubulin autoregulation.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

8355:LOC121402011
gene id: 8355:LOC121402011
uniprot id: A0A8J1MNR1
names: Similarity
messages: Belongs to the SNF7 family.

8355:LOC108715122
gene id: 8355:LOC108715122
uniprot id: A0A1L8GCZ4
uniprot id: A0A974HL51
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

8355:LOC108704306
gene id: 8355:LOC108704306
uniprot id: A0A1L8G0S8
uniprot id: A0A974HGS3
uniprot id: P62799
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by pak2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

8355:gpt.L
gene id: 8355:gpt.L
uniprot id: A0A8J0VMT4
uniprot id: A0A8J1KVP1
uniprot id: A0A8J1KYP7
uniprot id: Q6GM82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate.
messages: Homodimer.

8355:pds5b.S
gene id: 8355:pds5b.S
uniprot id: A0A8J1MBR9
uniprot id: Q5U241
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDS5 family.
messages: Interacts with the cohesin complex.
messages: Nucleus
messages: Phosphorylated in mitotic cells.
messages: Plays a role in androgen-induced proliferative arrest. Required for maintenance of sister chromatid cohesion during mitosis (By similarity).

8355:ciao2b.L
gene id: 8355:ciao2b.L
uniprot id: A0A974CU97
uniprot id: Q5M9B8
names: Similarity
messages: Belongs to the MIP18 family.

8355:tacr3.L
gene id: 8355:tacr3.L
uniprot id: A0A1L8HUZ1
uniprot id: A0A974DYS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:gdi1.L
gene id: 8355:gdi1.L
uniprot id: A0A1L8F5F5
uniprot id: A0A974C5C8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

8355:hsd17b11.L
gene id: 8355:hsd17b11.L
uniprot id: Q6DKA5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8355:unc5d.S
gene id: 8355:unc5d.S
uniprot id: A0A8J1MQM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

8355:setdb2.S
gene id: 8355:setdb2.S
uniprot id: Q6YI93
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Chromosome
messages: Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis (By similarity).
messages: In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
messages: Nucleus

8355:kat8.L
gene id: 8355:kat8.L
uniprot id: A0A8J1LV04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

8355:slc7a1.L
gene id: 8355:slc7a1.L
uniprot id: A0A1L8HIZ7
uniprot id: A0A974DPZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

8355:LOC108718162
gene id: 8355:LOC108718162
uniprot id: A0A8J1KVW4
uniprot id: A0A8J1KXC0
names: Similarity
messages: Belongs to the DNase I family.

8355:arhgef11.S
gene id: 8355:arhgef11.S
uniprot id: A0A1L8F4M1
uniprot id: A0A8J0THV3
uniprot id: A0A8J0TPI0
uniprot id: A0A8J0TQJ8
uniprot id: A0A8J0TRL2
uniprot id: A0A8J0TSM5
uniprot id: A0A974C4L2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

8355:p2ry2.L
gene id: 8355:p2ry2.L
uniprot id: A0A1L8HJU6
uniprot id: A0A8J0UK92
uniprot id: A0A974DRS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:klhdc10.L
gene id: 8355:klhdc10.L
uniprot id: Q5U580
names: Function
names: Similarity
names: Subunit
messages: Belongs to the KLHDC10 family.
messages: Component of a CRL2 E3 ubiquitin-protein ligase complex, also named ECS (Elongin BC-CUL2/5-SOCS-box protein) complex, composed of CUL2, Elongin BC (ELOB and ELOC), RBX1 and substrate-specific adapter KLHDC10.
messages: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(KLHDC10) complex specifically recognizes proteins with a proline-glycine (Pro-Gly) or an alanine tail (CAT tail) at the C-terminus, leading to their ubiquitination and degradation. The CRL2(KLHDC10) complex is involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: CRL2(KLHDC10) acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation.

8355:LOC121402026
gene id: 8355:LOC121402026
uniprot id: A0A310U7F3
names: Subcellular Location Annotation
messages: Membrane

8355:chek1.L
gene id: 8355:chek1.L
uniprot id: A0A1L8FL95
uniprot id: A0A8J0TAT4
uniprot id: A0A974CGL2
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.

8355:LOC108718546
gene id: 8355:LOC108718546
uniprot id: A0A8J1KYD0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

8355:kit.S
gene id: 8355:kit.S
uniprot id: Q6P6Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Membrane

8355:chat.L
gene id: 8355:chat.L
uniprot id: A0A8J0TA63
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

8355:myoz1.S
gene id: 8355:myoz1.S
uniprot id: A0A8J0T4F7
uniprot id: A0A974H9W3
uniprot id: Q7ZYN8
names: Similarity
messages: Belongs to the myozenin family.

8355:LOC121403162
gene id: 8355:LOC121403162
uniprot id: A0A8J1MYX9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natural cytotoxicity receptor (NCR) family.
messages: Cell membrane
messages: Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6.
messages: Membrane

8355:degs3.S
gene id: 8355:degs3.S
uniprot id: A0A8J0TH86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:hmgn1.L
gene id: 8355:hmgn1.L
uniprot id: A0A8J0UBD2
uniprot id: A0A8J0UBI1
uniprot id: A0A8J0UE14
uniprot id: A0A974DMP5
uniprot id: Q9I988
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

8355:nosip.S
gene id: 8355:nosip.S
uniprot id: A0A1L8FGZ1
uniprot id: A0A974CCW2
uniprot id: Q6NUH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOSIP family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face (By similarity). Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity (By similarity).
messages: Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity.
messages: Nucleus

8355:mdm1.L
gene id: 8355:mdm1.L
uniprot id: A0A1L8GYI8
uniprot id: A0A8J0UQW9
uniprot id: A0A8J0UU40
uniprot id: A0A8J1MKI8
uniprot id: A0A974HSI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM1 family.
messages: Nucleus
messages: centriole

8355:arhgef2.L
gene id: 8355:arhgef2.L
uniprot id: A0A1L8FCZ7
uniprot id: A0A8J1LJB6
uniprot id: A0A8J1LJH2
uniprot id: A0A8J1LKN5
uniprot id: A0A974CAQ5
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Golgi apparatus
messages: Vesicle
messages: spindle
messages: tight junction

8355:pdlim1.L
gene id: 8355:pdlim1.L
uniprot id: A0A8J1L489
uniprot id: A0A8J1L4B1
uniprot id: A0A8J1L5Z4
uniprot id: Q7SYV2
names: Subcellular Location Annotation
messages: Z line

8355:LOC108718467
gene id: 8355:LOC108718467
uniprot id: A0A1L8FV98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
messages: Membrane
messages: secretory vesicle membrane

8355:trap1.S
gene id: 8355:trap1.S
uniprot id: A0A1L8EQP6
uniprot id: A0A974BVS1
names: Similarity
messages: Belongs to the heat shock protein 90 family.

8355:slc38a7.L
gene id: 8355:slc38a7.L
uniprot id: Q6DFE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Lysosome membrane
messages: Symporter that selectively cotransports sodium ions and amino acids, such as L-glutamine and L-asparagine from the lysosome into the cytoplasm and may participates in mTORC1 activation. The transport activity requires an acidic lysosomal lumen.
messages: axon

8355:tacc3.L
gene id: 8355:tacc3.L
uniprot id: A0A1L8HT14
uniprot id: A0A974DW52
uniprot id: A0JMR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: Cytoplasm

8355:vsig1.L
gene id: 8355:vsig1.L
uniprot id: Q91664
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in thymocytes.
messages: Membrane

8355:vkorc1l1.S
gene id: 8355:vkorc1l1.S
uniprot id: A0A1L8H880
uniprot id: A0A974DHV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:zup1.S
gene id: 8355:zup1.S
uniprot id: A0A8J0VDQ7
uniprot id: A0A974CTL0
uniprot id: Q6DF95
names: Similarity
names: Subunit
messages: Belongs to the peptidase C78 family. ZUFSP subfamily.
messages: Interacts with RPA1 and RPA2.

8355:LOC121399408
gene id: 8355:LOC121399408
uniprot id: A0A8J1M2R1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neugrin family.
messages: Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.
messages: Mitochondrion membrane
messages: Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.

8355:gja7.S
gene id: 8355:gja7.S
uniprot id: A0A974BUI6
uniprot id: Q7ZXS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Belongs to the connexin family. Gamma-type subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8355:LOC108704970
gene id: 8355:LOC108704970
uniprot id: A0A8J1MUV4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:LOC121393898
gene id: 8355:LOC121393898
uniprot id: A0A8J1KQU4
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:LOC108705707
gene id: 8355:LOC108705707
uniprot id: A0A8J1MJR5
names: Subcellular Location Annotation
messages: Membrane

8355:reln.L
gene id: 8355:reln.L
uniprot id: A0A1L8GZC4
uniprot id: A0A8J0URD1
uniprot id: A0A8J0UUM3
uniprot id: A0A974DDU6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the reelin family.
messages: Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Oligomer of disulfide-linked homodimers. Binds to the ectodomains of VLDLR and LRP8/APOER2.
messages: extracellular matrix

8355:tp53bp2.S
gene id: 8355:tp53bp2.S
uniprot id: A0A1L8G181
uniprot id: A0A8J0VEM9
uniprot id: A0A974CQ58
names: Subcellular Location Annotation
messages: Nucleus

8355:desi1.L
gene id: 8355:desi1.L
uniprot id: Q6GLM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DeSI family.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins (By similarity). Has isopeptidase but not SUMO-processing activity (By similarity). Collaborates with ubqln4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm (By similarity).

8355:acss3.L
gene id: 8355:acss3.L
uniprot id: A0A1L8GY84
uniprot id: A0A974DB67
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

8355:crygbl.2.S
gene id: 8355:crygbl.2.S
uniprot id: A0A8J0U519
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:lep.S
gene id: 8355:lep.S
uniprot id: A0A974HRE1
uniprot id: Q563I5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the leptin family.
messages: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways.
messages: Secreted

8355:fam207a.L
gene id: 8355:fam207a.L
uniprot id: A0A974BZN3
uniprot id: Q6GNL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLX9 family.
messages: nucleolus

8355:b3galt5.2.S
gene id: 8355:b3galt5.2.S
uniprot id: A0A1L8H5E5
uniprot id: A0A974DG44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:LOC108704145
gene id: 8355:LOC108704145
uniprot id: A0A8J1KNZ9
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.

8355:KEF37 p07
gene id: 8355:KEF37_p07
uniprot id: P00419
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

8355:LOC108716379
gene id: 8355:LOC108716379
uniprot id: A0A8J1KQX9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:LOC121398104
gene id: 8355:LOC121398104
uniprot id: A0A8J1LU79
names: Subcellular Location Annotation
messages: Nucleus

8355:csad.L
gene id: 8355:csad.L
uniprot id: A0A1L8HII5
uniprot id: A0A8J0UFH4
uniprot id: A0A8J1MA97
names: Similarity
messages: Belongs to the group II decarboxylase family.

8355:cacng5.L
gene id: 8355:cacng5.L
uniprot id: A0A8J1LQP4
uniprot id: Q6GM02
names: Similarity
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

8355:pus7.L
gene id: 8355:pus7.L
uniprot id: A0A1L8GZ75
uniprot id: A0A8J1MHK1
uniprot id: A0A8J1MIJ5
uniprot id: A0A8J1MJI5
uniprot id: A0A974HT70
uniprot id: Q498E9
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

8355:LOC121394744
gene id: 8355:LOC121394744
uniprot id: A0A8J1KYP5
uniprot id: A0A8J1L0C2
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC121395394
gene id: 8355:LOC121395394
uniprot id: A0A8J1L5D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

8355:sdc4.S
gene id: 8355:sdc4.S
uniprot id: A0A974H0J0
uniprot id: B1H1N2
uniprot id: Q1AGV7
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan. Regulates non-canonical Wnt signaling, being necessary and sufficient for fibronectrin-mediated translocation of dvl2/dsh to the plasma membrane. Required for proper convergent extension movements during gastrulation, which shape the neural plate, and for subsequent neural tube closure.
messages: Expressed both maternally and zygotically.
messages: Expressed in the animal hemisphere from the 4-cell to the blastula stage. During gastrulation, expressed in the involuting dorsal mesoderm and ectoderm. After involution, localized mainly to the anterior neuroectoderm. At later stages, expressed in the brain, branchial arches, pronephros, tailbud, and at low levels in the somites.
messages: Interacts with the Wnt receptor fzd7 and its signal transducer dvl2/dsh.
messages: Membrane
messages: O-glycosylated; contains both chondroitin sulfate and heparan sulfate. Ser-36, Ser-65 and Ser-67 can all be modified by either chondroitin sulfate or heparan sulfate, and the protein exists in forms that contain only chondroitin sulfate, only heparan sulfate and both chondroitin sulfate and heparan sulfate.

8355:LOC108712576
gene id: 8355:LOC108712576
uniprot id: A0A1L8HWG7
uniprot id: A0A8J1KLY2
uniprot id: A0A974DYI1
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:taco1.S
gene id: 8355:taco1.S
uniprot id: A0A1L8EL56
uniprot id: A0A974BSP9
names: Similarity
messages: Belongs to the TACO1 family.

8355:atad2.L
gene id: 8355:atad2.L
uniprot id: A0A8J1KZ22
uniprot id: A0A8J1L0P4
names: Similarity
messages: Belongs to the AAA ATPase family.

8355:akap8l.L
gene id: 8355:akap8l.L
uniprot id: A0A1L8H2H0
uniprot id: A0A8J0UTA7
uniprot id: A0A974DDT9
names: Similarity
messages: Belongs to the AKAP95 family.

8355:LOC495206
gene id: 8355:LOC495206
uniprot id: A0A1L8H357
names: Subcellular Location Annotation
messages: Secreted

8355:fermt1.S
gene id: 8355:fermt1.S
uniprot id: A0A974HH20
uniprot id: Q7ZYR0
names: Similarity
messages: Belongs to the kindlin family.

8355:thyn1.L
gene id: 8355:thyn1.L
uniprot id: A0A1L8FL07
uniprot id: A0A8J0TAF6
uniprot id: A0A974HBV4
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

8355:LOC108700624
gene id: 8355:LOC108700624
uniprot id: A0A1L8EZR3
names: Subcellular Location Annotation
messages: Nucleus

8355:gpr179.L
gene id: 8355:gpr179.L
uniprot id: A0A1L8ES17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8355:or5f1l1.1.L
gene id: 8355:or5f1l1.1.L
uniprot id: A0A8J0UGV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8355:LOC108705539
gene id: 8355:LOC108705539
uniprot id: A0A8J1MKT4
names: Subcellular Location Annotation
messages: Cytoplasm

8355:med9.L
gene id: 8355:med9.L
uniprot id: A0A8J1LQ37
uniprot id: A0A974C0P2
uniprot id: Q4V7L5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 9 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8355:sh3gl2.L
gene id: 8355:sh3gl2.L
uniprot id: A0A974I4G0
uniprot id: Q5HZS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

8355:ankrd34b.S
gene id: 8355:ankrd34b.S
uniprot id: A0A1L8HRA5
uniprot id: A0A974DW90
names: Similarity
messages: Belongs to the ANKRD34 family.

8355:sh3bp5.S
gene id: 8355:sh3bp5.S
uniprot id: A0A1L8FRK2
uniprot id: A0A974CIU6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

8355:LOC108711766
gene id: 8355:LOC108711766
uniprot id: A0A8J0USI6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:kcna2.L
gene id: 8355:kcna2.L
uniprot id: A0A1L8HE21
uniprot id: A0A974DLS2
uniprot id: Q98TW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.
messages: Cell membrane
messages: Membrane

8355:sgo2.S
gene id: 8355:sgo2.S
uniprot id: A0A1L8EPV7
uniprot id: A0A8J1LZ78
uniprot id: A0A8J1M060
uniprot id: A0A974BV96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

8355:sh3bp5l.S
gene id: 8355:sh3bp5l.S
uniprot id: A0A1L8F3H4
uniprot id: A0A974H6H0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

8355:LOC108712404
gene id: 8355:LOC108712404
uniprot id: A0A8J0UTZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

8355:LOC108713301
gene id: 8355:LOC108713301
uniprot id: A0A8J0US32
uniprot id: A0A8J1MS99
uniprot id: A0A8J1MSA4
uniprot id: A0A8J1MSF4
uniprot id: A0A8J1MSG0
uniprot id: A0A8J1MTB7
uniprot id: A0A8J1MTM1
uniprot id: A0A8J1MTM6
uniprot id: A0A8J1MUL2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

8355:qprt.L
gene id: 8355:qprt.L
uniprot id: A0A8J0PYA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

8355:ptgfr.L
gene id: 8355:ptgfr.L
uniprot id: A0A1L8GLN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:nubpl.L
gene id: 8355:nubpl.L
uniprot id: A0A1L8FAX3
uniprot id: A0A974H8G5
names: Similarity
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.

8355:grb7.S
gene id: 8355:grb7.S
uniprot id: A0A1L8EKL3
uniprot id: A0A8J0TZY6
uniprot id: A0A8J1M2E7
uniprot id: A0A974BS83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

8355:glp2r.S
gene id: 8355:glp2r.S
uniprot id: A0A1L8EN96
names: Subcellular Location Annotation
messages: Membrane

8355:cyba.S
gene id: 8355:cyba.S
uniprot id: A0A8J0U4K2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p22phox family.
messages: Cell membrane
messages: Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).
messages: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
messages: Membrane

8355:LOC108710968
gene id: 8355:LOC108710968
uniprot id: A0A1L8GXT9
uniprot id: A0A974DBB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:msrb3.L
gene id: 8355:msrb3.L
uniprot id: A0A1L8GYG2
uniprot id: A0A8J1MLG0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

8355:c7.S
gene id: 8355:c7.S
uniprot id: Q6INM0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:zfhx2.S
gene id: 8355:zfhx2.S
uniprot id: A0A8J1M344
names: Subcellular Location Annotation
messages: Nucleus

8355:slc26a4.3.S
gene id: 8355:slc26a4.3.S
uniprot id: Q5QKY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sodium-independent transporter of chloride and iodide.

8355:khdrbs3.L
gene id: 8355:khdrbs3.L
uniprot id: A0A1L8G070
uniprot id: A0A974CPG7
names: Similarity
messages: Belongs to the KHDRBS family.

8355:slc48a1.S
gene id: 8355:slc48a1.S
uniprot id: A0A974HWH1
uniprot id: Q4FZW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HRG family.
messages: Endosome membrane
messages: Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment. In macrophages, is the heme transporter for heme-iron recycling. Essential for macrophage iron homeostasis, transports heme from the phagolysosome to the cytoplasm during erythrophagocytosis (EP).
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

8355:snrpa1.L
gene id: 8355:snrpa1.L
uniprot id: A0A1L8H150
uniprot id: A0A974DEZ9
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

8355:ncl.S
gene id: 8355:ncl.S
uniprot id: A0A8J1KUE9
uniprot id: Q06459
names: Subcellular Location Annotation
messages: nucleolus

8355:zpbp2.L
gene id: 8355:zpbp2.L
uniprot id: A0A974H255
uniprot id: A3F966
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zona pellucida-binding protein Sp38 family.
messages: Secreted
messages: acrosome

8355:vcl.S
gene id: 8355:vcl.S
uniprot id: A0A8J0TUB3
uniprot id: A0A8J0U1K5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction
messages: podosome

8355:ptp4a3.L
gene id: 8355:ptp4a3.L
uniprot id: A0A8J0VIJ6
uniprot id: A0A974CPD6
uniprot id: Q6L7J1
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

8355:ccnl1.S
gene id: 8355:ccnl1.S
uniprot id: A0A8J0VG75
names: Similarity
messages: Belongs to the cyclin family.

8355:slc26a3.3.S
gene id: 8355:slc26a3.3.S
uniprot id: A0A1L8GTW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
messages: Membrane

8355:vdac2.S
gene id: 8355:vdac2.S
uniprot id: A0A8J1LCV9
uniprot id: Q52KY1
names: Similarity
messages: Belongs to the eukaryotic mitochondrial porin family.

8355:gnai1.S
gene id: 8355:gnai1.S
uniprot id: P27044
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity).
messages: Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Part of a spindle orientation complex. Identified in complex with the beta subunit GNB1 and the gamma subunit GNG1. Identified in complex with the beta subunit GNB1 and the gamma subunit GNG2. GTP binding causes dissociation of the heterotrimer, liberating the individual subunits so that they can interact with downstream effector proteins (By similarity).
messages: Membrane
messages: Myristoylation at Gly-2 is required for membrane anchoring before palmitoylation.
messages: Nucleus
messages: Palmitoylation at Cys-3 varies with membrane lipid composition.
messages: cell cortex
messages: centrosome

8355:smyd5.L
gene id: 8355:smyd5.L
uniprot id: Q6GPQ4
names: Function
names: Similarity
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 to form trimethylated histone H4 lysine 20 (H4K20me3) which represents a specific tag for epigenetic transcriptional repression.

8355:LOC108701942
gene id: 8355:LOC108701942
uniprot id: A0A8J0TPI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:nxpe3l.6.S
gene id: 8355:nxpe3l.6.S
uniprot id: A0A8J1L275
names: Similarity
messages: Belongs to the NXPE family.

8355:LOC108714032
gene id: 8355:LOC108714032
uniprot id: A0A8J0V592
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:stra6.S
gene id: 8355:stra6.S
uniprot id: A0A1L8GT99
uniprot id: A0A974D7L1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:pygb.L
gene id: 8355:pygb.L
uniprot id: A0A8J1MYB1
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

8355:LOC108712716
gene id: 8355:LOC108712716
uniprot id: A0A8J0UW14
uniprot id: A0A8J0UZG4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:tlcd5.L
gene id: 8355:tlcd5.L
uniprot id: A0A1L8FLG7
uniprot id: A0A974HCD8
names: Subcellular Location Annotation
messages: Membrane

8355:glrx.L
gene id: 8355:glrx.L
uniprot id: A0A974E3I0
uniprot id: Q6P7J6
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

8355:ifitm5.L
gene id: 8355:ifitm5.L
uniprot id: A0A1L8GJ42
uniprot id: A0A8J1MWL9
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8355:tysnd1.L
gene id: 8355:tysnd1.L
uniprot id: A0A1L8FJW0
uniprot id: A0A974CEN3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1B family.
messages: Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.
messages: Peroxisome
messages: The full-lengh TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity.

8355:LOC108703785
gene id: 8355:LOC108703785
uniprot id: A0A310TTQ1
uniprot id: A0A974BPZ0
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:ano7.L
gene id: 8355:ano7.L
uniprot id: A0A8J1L8J3
uniprot id: A0A8J1LB40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

8355:LOC121398939
gene id: 8355:LOC121398939
uniprot id: A0A8J1LZL5
names: Similarity
messages: Belongs to the cyclin family.

8355:serpind1.S
gene id: 8355:serpind1.S
uniprot id: Q4KLF2
names: Similarity
messages: Belongs to the serpin family.

8355:hccs.S
gene id: 8355:hccs.S
uniprot id: A0A8J0PYY3
uniprot id: Q6DCG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

8355:LOC108711748
gene id: 8355:LOC108711748
uniprot id: A0A1L8H3B5
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

8355:aph1a.L
gene id: 8355:aph1a.L
uniprot id: A0A1L8FCC5
uniprot id: A0A8J0TDU1
uniprot id: A0A974H909
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

8355:mtx2.L
gene id: 8355:mtx2.L
uniprot id: Q6Q8B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

8355:stk39.S
gene id: 8355:stk39.S
uniprot id: A0A8J0U3H9
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

8355:hey1.S
gene id: 8355:hey1.S
uniprot id: Q9I8A3
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the HEY family.
messages: By Notch signaling.
messages: Downstream effector of Notch signaling. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Acts as a suppressor of neurogenesis by antagonizing proneural gene function. Functions during floorplate development. Plays a role in pronephros formation in the inhibition of distal tubule and duct cell fates and the promotion of glomus and proximal tubule formation.
messages: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA in the form of homodimer or more strongly as a heterodimer with hes1/hairy1 or hes4-B/hairy2b. Also weakly interacts with the bHLH proteins hes2, neurod1 and neurod4/ath3. Interacts (via Orange domain) with ccdc89/boip (via C-terminus).
messages: Expressed throughout embryogenesis, with expression rising after neurulation.
messages: Expression in late gastrula and early neurula embryos is restricted to dorsal endodermal cells and the medial neural plate and in dorsal endodermal cells. Expression fills exactly the gap in between the two rows of motor neurons in the ventral neural tube. At later stages, expressed in the floor plate, in hypochord cells and in the somitogenic and anterior presomitic mesoderm. By tailbud stage, also highly expressed in the dorsal hindbrain, telencephalon and eye vesicles, olfactory placodes, branchial arches, tail fin and somites. Expression in the somite, eye, head and branchial arches persists throughout organogenesis. In addition, despite being absent in the early heart field, expression begins within the linear heart tube at stages 32-35. Also expressed from the early-tailbud stage in the dorsoanterior region of the developing pronephros. During early tailbud stages, localized to the most dorsoanterior portion of the pronephric anlagen. During late tailbud to early tadpole stages, expression marks the most dorsoanterior portion of the pronephros with expression becoming progressively restricted to the tip of the forming tubules. Pronephric expression is no longer detectable at late tadpole stages (stage 35). In adults, strongest expression is observed in the brain, eye, heart, lung, muscle, ovary, skin, spleen and testis.
messages: Nucleus
messages: The C-terminal YRPW motif is not required for transcriptional repressor activity and is unable to recruit groucho.
messages: The Orange domain, downstream sequence and the bHLH are required for efficient heterodimerization with hes/hairy proteins, and for transcriptional repressor activity.

8355:gnrhr2.S
gene id: 8355:gnrhr2.S
uniprot id: A0A1L8GSR0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:csf3.L
gene id: 8355:csf3.L
uniprot id: A0A1L8ERX3
uniprot id: A0A974BX13
names: Similarity
messages: Belongs to the IL-6 superfamily.

8355:serpinh1.L
gene id: 8355:serpinh1.L
uniprot id: Q08AX2
names: Function
names: Similarity
messages: Belongs to the serpin family.
messages: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

8355:gpm6b.S
gene id: 8355:gpm6b.S
uniprot id: A0A8J0UGN0
uniprot id: A0A8J0UHY8
uniprot id: A0A8J0UKU2
uniprot id: A0A974DI06
uniprot id: Q6AZU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

8355:cd9.S
gene id: 8355:cd9.S
uniprot id: Q6GQE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Membrane
messages: extracellular exosome

8355:pim1.L
gene id: 8355:pim1.L
uniprot id: A0A8J0UZE1
uniprot id: A0A974D641
uniprot id: Q5U489
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

8355:mus81.L
gene id: 8355:mus81.L
uniprot id: A0A1L8GJY4
uniprot id: A0A8J0V115
uniprot id: A0A8J0V4V2
uniprot id: A0A8J1MW06
uniprot id: A0A8J1MXD1
uniprot id: A0A974HN24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
messages: Interacts with EME1.
messages: Nucleus

8355:slco2b1.L
gene id: 8355:slco2b1.L
uniprot id: A0A8J1M5T3
uniprot id: A0A8J1M5V4
uniprot id: Q32NK1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:LOC121394141
gene id: 8355:LOC121394141
uniprot id: A0A8J1KRY3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:atp5pd.L
gene id: 8355:atp5pd.L
uniprot id: A0A974BY34
uniprot id: Q6IRP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase d subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

8355:dpm1.S
gene id: 8355:dpm1.S
uniprot id: Q4QR31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

8355:atp5mg.L
gene id: 8355:atp5mg.L
uniprot id: Q66L24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

8355:cd247.L
gene id: 8355:cd247.L
uniprot id: B1NA61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

8355:LOC108712610
gene id: 8355:LOC108712610
uniprot id: A0A1L8GR36
uniprot id: A0A8J0UVI8
uniprot id: A0A8J1MQ66
uniprot id: A0A8J1MSE4
uniprot id: A0A974D7W1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8355:en2.S
gene id: 8355:en2.S
uniprot id: A0A974HDE3
uniprot id: B7ZPM7
uniprot id: P52730
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Engrailed homeobox family.
messages: Belongs to the engrailed homeobox family.
messages: In addition to the main band of expression at the midbrain-hindbrain boundary, the protein is expressed in the mandibular arch, the optic tectum and the region of anterior pituitary.
messages: Nucleus

8355:mbtps2.L
gene id: 8355:mbtps2.L
uniprot id: A0A1L8HDN7
uniprot id: A0A974HY68
names: Similarity
messages: Belongs to the peptidase M50A family.

8355:exoc4.L
gene id: 8355:exoc4.L
uniprot id: A0A1L8GZQ8
uniprot id: A0A974DE08
names: Function
names: Similarity
messages: Belongs to the SEC8 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

8355:LOC108710741
gene id: 8355:LOC108710741
uniprot id: A0A1L8GWC5
uniprot id: A0A974DBW5
names: Similarity
messages: Belongs to the CDI family.

8355:skor1.L
gene id: 8355:skor1.L
uniprot id: A0A1L8H173
uniprot id: A0A8J0UST6
uniprot id: A0A974DDM9
names: Similarity
messages: Belongs to the SKI family.

8355:rab33b.S
gene id: 8355:rab33b.S
uniprot id: A0A1L8HLW3
uniprot id: A0A974DTA7
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

8355:vil1.L
gene id: 8355:vil1.L
uniprot id: A0A1L8EVQ4
uniprot id: A0A974BZ71
names: Similarity
messages: Belongs to the villin/gelsolin family.

8355:cers5.L
gene id: 8355:cers5.L
uniprot id: A0A8J1M592
uniprot id: A0A974DSA3
uniprot id: Q8QGA3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

8355:ndst2.S
gene id: 8355:ndst2.S
uniprot id: A0A8J1LBZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

8355:grik5.S
gene id: 8355:grik5.S
uniprot id: A0A1L8FGX2
uniprot id: A0A8J1LEQ9
uniprot id: A0A974HAF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8355:slc7a4.L
gene id: 8355:slc7a4.L
uniprot id: A0A974E337
uniprot id: Q6NRJ1
names: Subcellular Location Annotation
messages: Membrane

8355:sin3b.L
gene id: 8355:sin3b.L
uniprot id: A0A1L8HXG3
uniprot id: A0A8J0UTC8
uniprot id: A0A8J1KQA3
uniprot id: A0A974I497
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108700329
gene id: 8355:LOC108700329
uniprot id: A0A1L8F4H0
uniprot id: A0A974C4R6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:kctd3.L
gene id: 8355:kctd3.L
uniprot id: Q6AX43
names: Similarity
messages: Belongs to the KCTD3 family.

8355:fam83g.L
gene id: 8355:fam83g.L
uniprot id: Q5XK72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAM83 family.
messages: Interacts with SMAD1 (via MH2 domain); in a SMAD4-independent manner.
messages: Nucleus
messages: Substrate for type I BMP receptor kinase involved in regulation of some target genes of the BMP signaling pathway. May also play a role in other signaling pathways.
messages: cytosol

8355:crygdl.16.S
gene id: 8355:crygdl.16.S
uniprot id: A0A1L8HNR7
uniprot id: A0A974DUX2
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:tm7sf2.L
gene id: 8355:tm7sf2.L
uniprot id: A0A1L8GJH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

8355:phactr3.S
gene id: 8355:phactr3.S
uniprot id: A0A1L8ELJ3
uniprot id: A0A8J0TZ85
uniprot id: A0A8J0U0G5
uniprot id: A0A974BT05
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

8355:ppara.L
gene id: 8355:ppara.L
uniprot id: A0A8J1MID8
uniprot id: Q5PPL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

8355:ppp6r3.S
gene id: 8355:ppp6r3.S
uniprot id: Q6NRF1
names: Function
names: Similarity
messages: Belongs to the SAPS family.
messages: Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit (By similarity).

8355:ndufb1.L
gene id: 8355:ndufb1.L
uniprot id: A0A8J0TBY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

8355:abo2.S
gene id: 8355:abo2.S
uniprot id: A0A1L8EM77
uniprot id: A0A974BTR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8355:egfl8.L
gene id: 8355:egfl8.L
uniprot id: A0A1L8F8E3
uniprot id: A0A974C780
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108703413
gene id: 8355:LOC108703413
uniprot id: A0A8J0TUH3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:pea15.S
gene id: 8355:pea15.S
uniprot id: A0A1L8F4Q4
uniprot id: A0A974C4Y0
names: Subcellular Location Annotation
messages: Cytoplasm

8355:sntb2.S
gene id: 8355:sntb2.S
uniprot id: A0A1L8GF31
uniprot id: A0A974HLP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

8355:LOC108716628
gene id: 8355:LOC108716628
uniprot id: A0A8J0VA39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PET117 family.
messages: Mitochondrion

8355:lpar1.L
gene id: 8355:lpar1.L
uniprot id: A0A974E0A4
uniprot id: B7ZPQ9
uniprot id: Q9PU16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cell surface
messages: Endosome
messages: Expressed at high levels in oocytes and at lower levels in brain and spinal cord. Below detection level in lung, heart, kidney, liver, muscle, stomach, and intestine.
messages: Membrane
messages: Receptor for lysophosphatidic acid (LPA)(PubMed:11278944). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:11278944). Signaling triggers an increase of cytoplasmic Ca(2+) levels. Signaling leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate. Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape (PubMed:11278944). Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction. Promotes the activation of Rho and the formation of actin stress fibers. Promotes formation of lamellipodia at the leading edge of migrating cells via activation of Rac. Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding. Promotes cell proliferation in response to lysophosphatidic acid (By similarity).

8355:phlda2.L
gene id: 8355:phlda2.L
uniprot id: A1L2W9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PHLDA2 family.
messages: Cytoplasm
messages: Membrane
messages: Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity).
messages: The PH domain binds phosphoinositides with a broad specificity. It may compete with the PH domain of some other proteins, thereby interfering with their binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity).

8355:XB5810926.L
gene id: 8355:XB5810926.L
uniprot id: A1L2K6
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:gpt.S
gene id: 8355:gpt.S
uniprot id: A0A1L8FU71
uniprot id: A0A8J0T7L5
uniprot id: A0A8J1L3P3
uniprot id: A0A8J1L3Q6
uniprot id: A0A8J1L3S0
uniprot id: A0A974CM24
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

8355:rpl37.S
gene id: 8355:rpl37.S
uniprot id: Q6GN79
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

8355:gabbr1.L
gene id: 8355:gabbr1.L
uniprot id: A0A1L8F895
uniprot id: A0A8J0TB84
uniprot id: A0A8J1LHE0
uniprot id: A0A974H7V4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:pnrc2.L
gene id: 8355:pnrc2.L
uniprot id: A0A974BQS7
uniprot id: Q66KH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNRC family. PNRC2 subfamily.
messages: Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for upf1/rent1 localization to the P-body. Also acts as a nuclear receptor coactivator (By similarity).
messages: Nucleus
messages: P-body

8355:cyld.S
gene id: 8355:cyld.S
uniprot id: A0A8J1KIA2
uniprot id: A0A8J1KLE1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: centrosome
messages: cilium basal body
messages: perinuclear region
messages: spindle

8355:bcor.L
gene id: 8355:bcor.L
uniprot id: A0A8J1M8J3
uniprot id: A0A8J1M8J7
uniprot id: A0A8J1M8P9
names: Similarity
messages: Belongs to the BCOR family.

8355:LOC108709490
gene id: 8355:LOC108709490
uniprot id: A0A8J1MDN6
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:nptxr.S
gene id: 8355:nptxr.S
uniprot id: A0A1L8GH07
uniprot id: A0A8J0V882
uniprot id: A0A974HMJ9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:riok2.L
gene id: 8355:riok2.L
uniprot id: A0A8J0U6L1
uniprot id: A0A8J1M5E1
uniprot id: Q6AZQ3
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

8355:cdnf.L
gene id: 8355:cdnf.L
uniprot id: A0A1L8GZJ7
uniprot id: A0A8J0URG0
uniprot id: A0A974DDX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

8355:foxf1.S
gene id: 8355:foxf1.S
uniprot id: Q9W707
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: At the late gastrula stage, expressed in the presumptive ventrolateral mesoderm. During neurulation and tailbud stages, expressed in the lateral plate mesoderm and in the neural crest-derived structures of the head and branchial arches. During tailbud stages, expressed in the pronephros and pronephros ducts and in cells that migrate from the dorsolateral plate to the ventral region of the embryo (with the notable exception of the heart). These cells may represent hematopoietic or endothelial progenitor cells.
messages: By bmp4, probably acting indirectly via t/bra. Also induced to a lower extent by fgf and activin.
messages: Expression begins at late gastrula/early neurula stage and increases towards the end of embryogenesis.
messages: Nucleus
messages: Probable transcription factor. Required for smooth muscle (visceral mesoderm) differentiation during gut development. Also required for normal proliferation of the lateral plate mesoderm. Acts as a downstream mediator of bmp4-signaling.

8355:wars1.S
gene id: 8355:wars1.S
uniprot id: A0A974C1Q8
uniprot id: Q7ZWT7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

8355:cd8a.S
gene id: 8355:cd8a.S
uniprot id: A0A1L8HKJ9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:mat2a.L
gene id: 8355:mat2a.L
uniprot id: A0A974HU40
uniprot id: Q7ZY54
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

8355:exoc6b.S
gene id: 8355:exoc6b.S
uniprot id: A0A1L8HKG9
uniprot id: A0A8J0TZL9
uniprot id: A0A8J0U6R4
uniprot id: A0A8J0U7I9
uniprot id: A0A974DRD1
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

8355:gal3st4.5.L
gene id: 8355:gal3st4.5.L
uniprot id: A0A8J0UTQ1
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

8355:kif14.L
gene id: 8355:kif14.L
uniprot id: A0A1L8GN93
uniprot id: A0A974D558
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8355:LOC121393085
gene id: 8355:LOC121393085
uniprot id: A0A8J1LZV9
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8355:irx5.L
gene id: 8355:irx5.L
uniprot id: Q90XW5
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes. Does not appear to play a role in pronephros kidney development. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12.
messages: Belongs to the TALE/IRO homeobox family.
messages: By hoxb4 and hoxb5. Down-regulated by hoxb9.
messages: Early in gastrulation, expressed in cells beneath the blastopore lip. Subsequently expressed in the neural plate in overlapping patterns with other irx members, which all share an anterior border of expression. At the time of neural tube closure (stage 19) in regions of the midbrain, hindbrain, neural tube and optic vesicle, where expression continues during tailbud stages. In stage 34, expressed throughout the eye retina. Does not appear to be expressed in the developing heart or pronephros.
messages: Nucleus

8355:hbox10.S
gene id: 8355:hbox10.S
uniprot id: Q6GPM5
names: Subcellular Location Annotation
messages: Nucleus

8355:tubd1.L
gene id: 8355:tubd1.L
uniprot id: A0A974DPD6
uniprot id: Q5EAU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Nucleus
messages: centriole
messages: cilium

8355:LOC121399695
gene id: 8355:LOC121399695
uniprot id: A0A8J1M657
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:lrrc8a.L
gene id: 8355:lrrc8a.L
uniprot id: A0A8J1LG71
uniprot id: Q640H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

8355:cmss1.L
gene id: 8355:cmss1.L
uniprot id: Q68EV5
names: Similarity
messages: Belongs to the CMS1 family.

8355:prdm4.S
gene id: 8355:prdm4.S
uniprot id: A0A1L8GQR7
uniprot id: A0A974D5X7
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor involved in cell differentiation.
messages: Nucleus

8355:ints6.S
gene id: 8355:ints6.S
uniprot id: Q5U4W6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 6 family.
messages: Belongs to the multiprotein complex Integrator.
messages: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.
messages: Nucleus

8355:slc39a1l.L
gene id: 8355:slc39a1l.L
uniprot id: A0A1L8H0Z2
uniprot id: A0A974DET1
names: Subcellular Location Annotation
messages: Membrane

8355:atpsckmt.S
gene id: 8355:atpsckmt.S
uniprot id: A0A8J1L0S1
uniprot id: Q5I047
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANT/ATPSC lysine N-methyltransferase family.
messages: Mitochondrial protein-lysine N-methyltransferase that promotes chronic pain. Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia. Protein-lysine N-methyltransferase activity is dependent on S-adenosyl-L-methionine.
messages: Mitochondrion membrane

8355:celf5.S
gene id: 8355:celf5.S
uniprot id: B5LEQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Nucleus

8355:clpp.L
gene id: 8355:clpp.L
uniprot id: A0A974DG57
uniprot id: Q3KQF3
names: Similarity
messages: Belongs to the peptidase S14 family.

8355:LOC108704470
gene id: 8355:LOC108704470
uniprot id: A0A8J1LHS6
uniprot id: A0A8J1LHV7
names: Similarity
messages: Belongs to the Niban family.

8355:psmd3.S
gene id: 8355:psmd3.S
uniprot id: Q6GNC1
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

8355:usp33.L
gene id: 8355:usp33.L
uniprot id: A0A8J0V5V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: centrosome
messages: perinuclear region

8355:lmbr1.L
gene id: 8355:lmbr1.L
uniprot id: A0A8J0VNE6
uniprot id: A0A8J1KWR1
names: Similarity
messages: Belongs to the LIMR family.

8355:ftsj3.L
gene id: 8355:ftsj3.L
uniprot id: A0A1L8FKB5
uniprot id: A0A974CFH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
messages: Interacts with NIP7.
messages: Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.
messages: nucleolus

8355:pou3f1.S
gene id: 8355:pou3f1.S
uniprot id: P31363
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a transcription factor (By similarity). May play a role in neuronal differentiation (PubMed:1717323).
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Embryonic expression begins at the neural plate stage and continues throughout development to adulthood.
messages: In embryos at the neural fold stage, localized primarily in the anterior neural plate, and localized mostly in the anterior region of the nerve cord of neurula stage embryos. In tailbud stages, expressed predominantly in the eye and brain, with weak expression along the length of the nerve cord. In adults, expressed in skin and brain.
messages: Nucleus

8355:trim32.L
gene id: 8355:trim32.L
uniprot id: A0A1L8F6U8
uniprot id: A0A974C603
names: Similarity
messages: Belongs to the TRIM/RBCC family.

8355:derl1.L
gene id: 8355:derl1.L
uniprot id: Q6DJH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

8355:cd37.S
gene id: 8355:cd37.S
uniprot id: A0A1L8FGP7
uniprot id: A0A974CCJ5
uniprot id: Q66J31
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:mab21l3.S
gene id: 8355:mab21l3.S
uniprot id: A0A8J1MBH5
uniprot id: A0A8J1MBH8
uniprot id: A0A8J1MBU3
uniprot id: A0A8J1MD96
uniprot id: A0A974DG60
uniprot id: Q6GNM3
names: Similarity
messages: Belongs to the mab-21 family.

8355:cyp1a1.L
gene id: 8355:cyp1a1.L
uniprot id: Q9YI88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

8355:LOC108715679
gene id: 8355:LOC108715679
uniprot id: A0A1L8GGD6
uniprot id: A0A8J0V7W7
uniprot id: A0A974HM36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

8355:gusb.S
gene id: 8355:gusb.S
uniprot id: A0A1L8H877
uniprot id: A0A8J0UJK4
uniprot id: A0A974DI80
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Homotetramer.
messages: Inhibited by L-aspartic acid.
messages: Lysosome
messages: Plays an important role in the degradation of dermatan and keratan sulfates.

8355:pdk1.L
gene id: 8355:pdk1.L
uniprot id: A0A974H3L1
uniprot id: Q6IR88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

8355:mvb12a.L
gene id: 8355:mvb12a.L
uniprot id: A0A974C8D1
uniprot id: Q7ZYJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MVB12 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I).
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (By similarity).
messages: Cytoplasm
messages: Endosome
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

8355:fgf4.S
gene id: 8355:fgf4.S
uniprot id: A0A974D064
uniprot id: P48806
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: By derriere.
messages: Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Good candidate for an inducing factor with possible roles both in mesoderm induction at the blastula stage and in the formation of the anteroposterior axis at the gastrula stage.
messages: Secreted

8355:eif4a2.L
gene id: 8355:eif4a2.L
uniprot id: A0A1L8GA12
uniprot id: A0A8J0V8I4
uniprot id: A0A8J0VD96
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: Cytoplasm
messages: Nucleus
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

8355:cenpt.L
gene id: 8355:cenpt.L
uniprot id: B1H1T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-T/CNN1 family.
messages: Nucleus

8355:LOC108695751
gene id: 8355:LOC108695751
uniprot id: A0A1L8FJ86
uniprot id: A0A974HBA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

8355:LOC121398202
gene id: 8355:LOC121398202
uniprot id: A0A8J1LTV5
uniprot id: A0A8J1LTW7
uniprot id: A0A8J1LVC2
uniprot id: A0A8J1LW78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

8355:LOC101027275
gene id: 8355:LOC101027275
uniprot id: G3CH39
names: Similarity
names: Subunit
messages: Belongs to the SFTPD family.
messages: Oligomeric complex of 4 set of homotrimers.

8355:fgfr1op2.S
gene id: 8355:fgfr1op2.S
uniprot id: A0A8J0USX8
uniprot id: A0A974D8C1
uniprot id: Q8AVR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIKE family.
messages: Cytoplasm

8355:tomm40.L
gene id: 8355:tomm40.L
uniprot id: A0A974CGT7
uniprot id: Q7ZTM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tom40 family.
messages: Channel-forming protein essential for import of protein precursors into mitochondria.
messages: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex). Interacts with mitochondrial targeting sequences (By similarity).
messages: Membrane
messages: Mitochondrion outer membrane

8355:LOC108699950
gene id: 8355:LOC108699950
uniprot id: A0A8J0TG83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.

8355:cndp2.S
gene id: 8355:cndp2.S
uniprot id: A0A974CJF7
uniprot id: Q7T0R7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

8355:gnaq.L
gene id: 8355:gnaq.L
uniprot id: A0A974I3Y3
uniprot id: P38410
uniprot id: Q66IZ8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-alpha family. G(q) subfamily.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Golgi apparatus
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
messages: Nucleus
messages: Nucleus membrane
messages: Palmitoylated. Palmitoylation occurs in the Golgi and participates in the localization of GNAQ to the plasma membrane.

8355:btg1.L
gene id: 8355:btg1.L
uniprot id: Q8AVV7
names: Similarity
messages: Belongs to the BTG family.

8355:LOC121398255
gene id: 8355:LOC121398255
uniprot id: A0A8J1LUA8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:mgst2.L
gene id: 8355:mgst2.L
uniprot id: A0A1L8HUS6
uniprot id: A0A8J0TKQ4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:42sp43.L
gene id: 8355:42sp43.L
uniprot id: P25456
names: Function
names: Subunit
messages: The 42S RNP particle comprises four subunits each of which contains one molecule of 5S RNA, three molecules of tRNA, two molecules of p50 (EF1-alpha) and one molecule of the 5S RNA binding protein 43.
messages: p43 is a 5S RNA binding protein which is a major constituent of oocytes and comprises part of a 42S ribonucleoprotein storage particle.

8355:LOC108709756
gene id: 8355:LOC108709756
uniprot id: A0A8J0ULA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
messages: Belongs to the sulfotransferase 6 family.
messages: Membrane

8355:parvb.L
gene id: 8355:parvb.L
uniprot id: A0A8J1MJ57
uniprot id: A0A8J1MJU6
uniprot id: A0A8J1ML55
names: Similarity
messages: Belongs to the parvin family.

8355:coq4.L
gene id: 8355:coq4.L
uniprot id: A9JS49
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ4 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least coq3, coq4, coq5, coq6, coq7 and coq9.
messages: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
messages: Mitochondrion inner membrane
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

8355:atp6v0c.L
gene id: 8355:atp6v0c.L
uniprot id: Q7SYU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

8355:LOC108711111
gene id: 8355:LOC108711111
uniprot id: A0A1L8GYM6
uniprot id: A0A974DBU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

8355:susd4.S
gene id: 8355:susd4.S
uniprot id: A0A1L8G125
uniprot id: A0A8J1KS71
uniprot id: A0A8J1KVA9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:sowahb.L
gene id: 8355:sowahb.L
uniprot id: Q6NRK3
names: Similarity
messages: Belongs to the SOWAH family.

8355:kcnh5.S
gene id: 8355:kcnh5.S
uniprot id: A0A1L8F011
uniprot id: A0A8J0TQ36
uniprot id: A0A974C1L7
names: Subcellular Location Annotation
messages: Membrane

8355:dydc1.L
gene id: 8355:dydc1.L
uniprot id: A0A974HBL2
uniprot id: A3KNE0
names: Similarity
messages: Belongs to the dpy-30 family.

8355:LOC108705587
gene id: 8355:LOC108705587
uniprot id: A0A8J1MWU8
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:wdr12.L
gene id: 8355:wdr12.L
uniprot id: A0A8J1LSU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

8355:fzd6.S
gene id: 8355:fzd6.S
uniprot id: A0A8J0Q1K2
uniprot id: Q5XHG3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:pygm.L
gene id: 8355:pygm.L
uniprot id: A0A974HIW4
uniprot id: Q801T6
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

8355:sgcz.L
gene id: 8355:sgcz.L
uniprot id: A0A8J1MUD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

8355:ccnk.S
gene id: 8355:ccnk.S
uniprot id: A0A1L8F070
uniprot id: A0A974C1T1
names: Similarity
messages: Belongs to the cyclin family.

8355:hnrnpc.S
gene id: 8355:hnrnpc.S
uniprot id: A0A1L8HPW0
uniprot id: A0A8J1LHZ0
uniprot id: A0A8J1LJV5
uniprot id: A0A974DWF6
uniprot id: Q8AVP9
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

8355:bmt2.L
gene id: 8355:bmt2.L
uniprot id: A0A1L8GYV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BMT2 family.
messages: Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.
messages: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.

8355:lmnb3.L
gene id: 8355:lmnb3.L
uniprot id: A0A1L8H0P1
uniprot id: A0A974HTF7
uniprot id: P10999
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Expressed in oocytes.
messages: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
messages: Nucleus inner membrane
messages: There are at least five different lamins in Xenopus: the somatic lamins L(I), L(II), and A; the oocyte germinal vesicle lamin L(III); and the male germ cells lamin l(IV).

8355:gpx3.S
gene id: 8355:gpx3.S
uniprot id: A0A8J0PX46
names: Similarity
messages: Belongs to the glutathione peroxidase family.

8355:erg.L
gene id: 8355:erg.L
uniprot id: Q9W700
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8355:LOC121393659
gene id: 8355:LOC121393659
uniprot id: A0A8J1KMY4
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8355:aadac.L
gene id: 8355:aadac.L
uniprot id: A0A1L8GAW4
uniprot id: A0A974HJZ5
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

8355:LOC108696911
gene id: 8355:LOC108696911
uniprot id: A0A1L8HYE3
uniprot id: A0A974E056
names: Subcellular Location Annotation
messages: Nucleus

8355:sacm1l.L
gene id: 8355:sacm1l.L
uniprot id: Q6GM29
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2).

8355:rrn3.L
gene id: 8355:rrn3.L
uniprot id: A0A8J0TJC3
uniprot id: A0A8J1LR08
uniprot id: Q2T9I7
names: Similarity
messages: Belongs to the RRN3 family.

8355:rgs12.S
gene id: 8355:rgs12.S
uniprot id: A0A8J0U1N5
uniprot id: A0A8J0U2Y7
uniprot id: A0A8J0U2Z2
names: Subcellular Location Annotation
messages: Cytoplasm

8355:amt.L
gene id: 8355:amt.L
uniprot id: A0A974D5Q8
uniprot id: Q0IH11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

8355:strn.S
gene id: 8355:strn.S
uniprot id: A0A8J0VAK5
uniprot id: A0A974HH85
uniprot id: Q66JA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

8355:aldh3b1.L
gene id: 8355:aldh3b1.L
uniprot id: A0A1L8I0K0
uniprot id: A0A974E1T6
uniprot id: Q6DCC8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

8355:ccnt1.L
gene id: 8355:ccnt1.L
uniprot id: A0A1L8HHN4
uniprot id: A0A8J0UF82
uniprot id: A0A974HYX9
names: Similarity
messages: Belongs to the cyclin family.

8355:fam3a.L
gene id: 8355:fam3a.L
uniprot id: Q7ZYE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

8355:rspo1.S
gene id: 8355:rspo1.S
uniprot id: A0A8J0UKN1
names: Similarity
messages: Belongs to the R-spondin family.

8355:chst1.L
gene id: 8355:chst1.L
uniprot id: A0A1L8GIV7
uniprot id: A0A974HMQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

8355:xirp1.S
gene id: 8355:xirp1.S
uniprot id: A0A8J1L6J8
names: Domain
names: Similarity
messages: Belongs to the Xin family.
messages: Xin repeats bind F-actin.

8355:rpl17.S
gene id: 8355:rpl17.S
uniprot id: A0A974DVF5
uniprot id: Q6AZV3
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

8355:slc26a2.2.L
gene id: 8355:slc26a2.2.L
uniprot id: A0A1L8GXV8
uniprot id: A0A8J1MK78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

8355:e2f7.L
gene id: 8355:e2f7.L
uniprot id: A0A8J0UP35
uniprot id: A0A8J0US24
uniprot id: A0JMR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

8355:csrnp3.L
gene id: 8355:csrnp3.L
uniprot id: A0A1L8EW36
uniprot id: A0A974H3J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

8355:slc16a1.S
gene id: 8355:slc16a1.S
uniprot id: A0A974DJ49
uniprot id: Q7ZYH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

8355:MGC52899
gene id: 8355:MGC52899
uniprot id: A0A974BRN6
uniprot id: Q801R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

8355:llgl1.S
gene id: 8355:llgl1.S
uniprot id: Q6NRG4
names: Similarity
messages: Belongs to the WD repeat L(2)GL family.

8355:cox18.L
gene id: 8355:cox18.L
uniprot id: A0A1L8HVD3
uniprot id: A0A8J0ULV8
uniprot id: A0A8J0UN64
uniprot id: A0A974I3I6
uniprot id: Q3B8F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

8355:adamts14.L
gene id: 8355:adamts14.L
uniprot id: A0A8J0TA62
uniprot id: A0A8J0TB15
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8355:fut10.L
gene id: 8355:fut10.L
uniprot id: A0A8J0U9N3
uniprot id: A0A8J1KJ07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

8355:LOC108705258
gene id: 8355:LOC108705258
uniprot id: A0A8J1LBT3
uniprot id: A0A8J1LBY1
uniprot id: A0A8J1LDB8
uniprot id: A0A8J1LE83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MET18/MMS19 family.
messages: Component of the CIA complex.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus
messages: spindle

8355:appl1.L
gene id: 8355:appl1.L
uniprot id: Q6P9I3
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: Nucleus
messages: phagosome
messages: ruffle

8355:LOC108701136
gene id: 8355:LOC108701136
uniprot id: A0A1L8EUI2
uniprot id: A0A974BY53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8355:LOC108699053
gene id: 8355:LOC108699053
uniprot id: A0A8J1LKT3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:lpar4.L
gene id: 8355:lpar4.L
uniprot id: A0A974C6Y4
uniprot id: Q0IH81
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:cdk19.L
gene id: 8355:cdk19.L
uniprot id: A0A8J0V4K7
uniprot id: A0A974CV17
uniprot id: Q7T0R3
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:ccnj.S
gene id: 8355:ccnj.S
uniprot id: A0A1L8FEF4
names: Similarity
messages: Belongs to the cyclin family.

8355:dgkb.S
gene id: 8355:dgkb.S
uniprot id: A0A8J1L1K9
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

8355:LOC108706809
gene id: 8355:LOC108706809
uniprot id: A0A1L8HN07
uniprot id: A0A8J0U7U2
uniprot id: A0A974I197
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

8355:gstz1.L
gene id: 8355:gstz1.L
uniprot id: A0A8J0THW0
uniprot id: A0A974C7W4
uniprot id: Q3B8M0
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

8355:ptx.S
gene id: 8355:ptx.S
uniprot id: A0A8J1MZ50
uniprot id: A0A8J1N113
uniprot id: A0A8J1N1T5
uniprot id: Q2LK77
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC121393276
gene id: 8355:LOC121393276
uniprot id: A0A8J1KII5
uniprot id: A0A8J1KIK6
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC108704869
gene id: 8355:LOC108704869
uniprot id: A0A8J0U4Y8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:rasgrp3.S
gene id: 8355:rasgrp3.S
uniprot id: A0A1L8G260
uniprot id: A0A8J1KUC8
names: Similarity
messages: Belongs to the RASGRP family.

8355:LOC121393617
gene id: 8355:LOC121393617
uniprot id: A0A1L8G0S2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:LOC108701964
gene id: 8355:LOC108701964
uniprot id: A0A8J1LU68
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8355:LOC121400385
gene id: 8355:LOC121400385
uniprot id: A0A8J1MC04
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

8355:nme6.S
gene id: 8355:nme6.S
uniprot id: A0A8J1MRF7
names: Similarity
messages: Belongs to the NDK family.

8355:mul1.L
gene id: 8355:mul1.L
uniprot id: A0A1L8FPE1
uniprot id: A0A8J1L612
uniprot id: A0A974HDG4
uniprot id: Q6NTT6
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
messages: Homooligomer.
messages: Membrane
messages: Mitochondrion outer membrane
messages: The zinc finger domain is required for E3 ligase activity.

8355:LOC108704123
gene id: 8355:LOC108704123
uniprot id: A0A8J1LVH3
names: Subcellular Location Annotation
messages: Membrane

8355:brinp1.L
gene id: 8355:brinp1.L
uniprot id: A0A1L8F6W0
uniprot id: A0A974C5X6
names: Similarity
messages: Belongs to the BRINP family.

8355:LOC121397330
gene id: 8355:LOC121397330
uniprot id: A0A8J1LJY8
names: Subcellular Location Annotation
messages: Membrane

8355:nt5dc1.S
gene id: 8355:nt5dc1.S
uniprot id: A0A1L8G2Q9
uniprot id: A0A8J1KUT4
uniprot id: A0A8J1KUT9
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

8355:pum1.S
gene id: 8355:pum1.S
uniprot id: Q66KI6
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Interacts with cpeb1-a; interacts with unphosphorylated cpeb1-a but not phosphorylated (PubMed:12963108). Component of a complex with papd4, sympk, tacc3, parn, dazl and cpeb1 (PubMed:21098481).
messages: P-body
messages: Phosphorylated. Phosphorylation takes place at the time of dissociation of cpeb1-a from pum1 and the translational activation of ccnb1 mRNA.
messages: Present in oocytes (at protein level).
messages: Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of deadenylase complexes leading to translational inhibition and mRNA degradation (PubMed:12963108, PubMed:21098481). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (By similarity). Acts as a post-transcriptional repressor of ccnb1 mRNA during oocyte maturation (PubMed:12963108).
messages: The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half donut. RNA-binding occurs on the concave side of the surface. Pum1 is composed of 8 pumilio repeats of 36 residues; each repeat binds a single nucleotide in its RNA target. Residues at positions 12 and 16 of the pumilio repeat bind each RNA base via hydrogen bonding or van der Waals contacts with the Watson-Crick edge, while the amino acid at position 13 makes a stacking interaction. The recognition of RNA by pumilio repeats is base specific: cysteine and glutamine at position 12 and 16, respectively, bind adenine; asparagine and glutamine bind uracil; and serine and glutamate bind guanine.

8355:LOC121398770
gene id: 8355:LOC121398770
uniprot id: A0A8J1LY82
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:slc2a11.L
gene id: 8355:slc2a11.L
uniprot id: A0A1L8I0F1
uniprot id: A0A8J1KZE6
uniprot id: A0A974E170
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

8355:trpv4.S
gene id: 8355:trpv4.S
uniprot id: A0A1L8HQ36
uniprot id: A0A974DVT7
names: Subcellular Location Annotation
messages: Membrane

8355:apex1.S
gene id: 8355:apex1.S
uniprot id: A0A8J0UCG1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

8355:LOC108703414
gene id: 8355:LOC108703414
uniprot id: A0A8J1MPP1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108704404
gene id: 8355:LOC108704404
uniprot id: A0A8J0U3X0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8355:LOC108710442
gene id: 8355:LOC108710442
uniprot id: A0A8J0UPB4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:XB877238.S
gene id: 8355:XB877238.S
uniprot id: A0A1L8HB71
uniprot id: A0A974DJU8
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

8355:csnk1g1.L
gene id: 8355:csnk1g1.L
uniprot id: A0A1L8H0B6
uniprot id: A0A8J0UQT7
uniprot id: A0A8J1MLM4
uniprot id: A0A8J1MMI8
uniprot id: A0A8J1MNL0
uniprot id: A0A974HTN0
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

8355:gpr150.L
gene id: 8355:gpr150.L
uniprot id: A0A1L8I204
uniprot id: A0A974E2U9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:LOC121401016
gene id: 8355:LOC121401016
uniprot id: A0A8J1MJ03
names: Similarity
messages: Belongs to the WD repeat WDR91 family.

8355:LOC108717815
gene id: 8355:LOC108717815
uniprot id: A0A8J0VBZ6
uniprot id: A0A8J0VET3
uniprot id: A0A8J0VG27
uniprot id: A0A8J1KSP2
uniprot id: A0A8J1KSQ5
uniprot id: A0A8J1KSQ7
uniprot id: A0A8J1KUA7
uniprot id: A0A8J1KVR8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:pcdha13.L
gene id: 8355:pcdha13.L
uniprot id: A0A1L8GX05
uniprot id: A0A974DD36
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

8355:LOC108701018
gene id: 8355:LOC108701018
uniprot id: A0A8J1LUR9
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events.

8355:nsmce2.L
gene id: 8355:nsmce2.L
uniprot id: Q7ZXH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE2 family.
messages: Component of the SMC5-SMC6 complex which consists at least of smc5, smc6, nsmce2, nsmce1 and nsmce4a.
messages: E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair. Required for sister chromatid cohesion during prometaphase and mitotic progression (By similarity).
messages: Nucleus
messages: telomere

8355:smg8.S
gene id: 8355:smg8.S
uniprot id: A0A1L8H862
uniprot id: A0A974HW29
names: Function
names: Similarity
messages: Belongs to the SMG8 family.
messages: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

8355:znf652.S
gene id: 8355:znf652.S
uniprot id: Q6INV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

8355:dnm1l.S
gene id: 8355:dnm1l.S
uniprot id: A0A8J1MPS2
uniprot id: Q7ZXR2
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

8355:siva1.L
gene id: 8355:siva1.L
uniprot id: A0A974C9D5
uniprot id: A1L1C4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
messages: Nucleus

8355:vgll4l.S
gene id: 8355:vgll4l.S
uniprot id: A0A1L8F0R4
uniprot id: A0A974H512
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

8355:LOC108713119
gene id: 8355:LOC108713119
uniprot id: A0A8J0V1B0
uniprot id: A0A8J1MRP3
uniprot id: A0A8J1MSQ3
uniprot id: A0A8J1MTY7
names: Similarity
messages: Belongs to the DOCK family.

8355:LOC108704334
gene id: 8355:LOC108704334
uniprot id: A0A8J0TWJ9
uniprot id: A0A8J0U4B4
names: Subcellular Location Annotation
messages: Membrane

8355:wnk3.S
gene id: 8355:wnk3.S
uniprot id: A0A8J0TP57
uniprot id: A0A8J1LP21
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

8355:grtp1.S
gene id: 8355:grtp1.S
uniprot id: Q6GLZ0
names: Function
messages: May act as a GTPase-activating protein for Rab family protein(s).

8355:tns4.L
gene id: 8355:tns4.L
uniprot id: A0A1L8ERV4
uniprot id: A0A974BWE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

8355:popdc2.S
gene id: 8355:popdc2.S
uniprot id: Q640L0
names: Similarity
messages: Belongs to the popeye family.

8355:imp4.S
gene id: 8355:imp4.S
uniprot id: Q6NTP0
names: Subcellular Location Annotation
messages: nucleolus

8355:pih1d2.L
gene id: 8355:pih1d2.L
uniprot id: A0A1L8FLS6
uniprot id: A0A974CFS8
names: Similarity
messages: Belongs to the PIH1 family.

8355:LOC108710392
gene id: 8355:LOC108710392
uniprot id: A0A8J1MJK7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:insrr.L
gene id: 8355:insrr.L
uniprot id: A0A8J0T8H6
uniprot id: A0A8J0TEG3
uniprot id: Q6PA47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

8355:itgb8.S
gene id: 8355:itgb8.S
uniprot id: A0A8J1L1M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

8355:armc1.S
gene id: 8355:armc1.S
uniprot id: A0A974HEQ0
uniprot id: Q804W4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.
messages: Membrane
messages: Mitochondrion outer membrane

8355:LOC121401319
gene id: 8355:LOC121401319
uniprot id: A0A8J1MJG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8355:gabbr1.S
gene id: 8355:gabbr1.S
uniprot id: A0A1L8F3J3
uniprot id: A0A8J0TS04
uniprot id: A0A8J1LPJ1
uniprot id: A0A8J1LQY0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:cyp8b1.2.L
gene id: 8355:cyp8b1.2.L
uniprot id: A0A8J0VI79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

8355:LOC108696950
gene id: 8355:LOC108696950
uniprot id: A0A8J0TDR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

8355:trpm8.L
gene id: 8355:trpm8.L
uniprot id: A0A974BZU3
uniprot id: C5IJY6
names: Subcellular Location Annotation
messages: Membrane

8355:actr3.S
gene id: 8355:actr3.S
uniprot id: Q801P7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:17178911). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:17178911). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (Probable). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).
messages: Belongs to the actin family. ARP3 subfamily.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of actr2/arp2, actr3/arp3, arpc1 (arpc1a or arpc1b), arpc2, arpc3, arpc4 and arpc5.
messages: Nucleus
messages: cytoskeleton

8355:LOC108702074
gene id: 8355:LOC108702074
uniprot id: A0A1L8EZ59
uniprot id: A0A974C134
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8355:psen1.S
gene id: 8355:psen1.S
uniprot id: A0A1L8EZY9
uniprot id: A0A974C1L0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: The PAL motif is required for normal active site conformation.

8355:XB5944457.S
gene id: 8355:XB5944457.S
uniprot id: Q2KM82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8355:slc29a3.L
gene id: 8355:slc29a3.L
uniprot id: A0A1L8FK28
uniprot id: A0A8J0T1C4
uniprot id: A0A8J0TAC7
uniprot id: A0A974CES5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

8355:rpn1.S
gene id: 8355:rpn1.S
uniprot id: A0A974D2W7
uniprot id: Q7ZX69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

8355:pdgfra.S
gene id: 8355:pdgfra.S
uniprot id: A0A1L8HLA2
uniprot id: A0A974DTP6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.
messages: Membrane
messages: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.

8355:LOC108718971
gene id: 8355:LOC108718971
uniprot id: A0A1L8FWK8
uniprot id: A0A8J1KXH4
uniprot id: A0A8J1KXH5
uniprot id: A0A8J1KXH8
uniprot id: A0A8J1KXI0
uniprot id: A0A8J1KXI3
uniprot id: A0A8J1KZ50
uniprot id: A0A8J1L0F1
uniprot id: A0A8J1L0F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

8355:XB5721641.L
gene id: 8355:XB5721641.L
uniprot id: A1L2J5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:sbk3.L
gene id: 8355:sbk3.L
uniprot id: A0A1L8FMS6
uniprot id: A0A974HCH6
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:arl2bp.L
gene id: 8355:arl2bp.L
uniprot id: A0A1L8GKJ3
uniprot id: Q6DDX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL2BP family.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: Plays a role as an effector of the ADP-ribosylation factor-like protein 2, ARL2.
messages: centrosome
messages: cilium basal body
messages: spindle

8355:copb1.S
gene id: 8355:copb1.S
uniprot id: A0A974HL63
uniprot id: Q498K6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

8355:LOC121401293
gene id: 8355:LOC121401293
uniprot id: A0A8J1MIM8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:zranb1.S
gene id: 8355:zranb1.S
uniprot id: Q6NUB7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C64 family.
messages: Cytoplasm
messages: Nucleus
messages: The OTU domain mediates the deubiquitinating activity.
messages: The RanBP2-type zinc fingers, also called NZFs, mediate the interaction with ubiquitin and determine linkage specificity. RanBP2-type zinc fingers 1 and 2 (also named NZF1 and NZF2) specifically recognize and bind 'Lys-29'- and 'Lys-33'-linked ubiquitin. RanBP2-type zinc finger 3 (also named NZF3) binds 'Lys-33'-linked ubiquitin and shows weak binding to 'Lys-6'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin chains but it does not interact with 'Lys-29'-linked chains.
messages: The second ankyrin repeat ANK 2 is termed AnkUBD, it interacts with ubiquitin hydrophobic patch and contributes to linkage specificity.
messages: Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin (By similarity). Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones (By similarity). Positive regulator of the Wnt signaling pathway that deubiquitinates apc protein, a negative regulator of Wnt-mediated transcription (By similarity). Acts as a regulator of autophagy by mediating deubiquitination of pik3c3/vps34, thereby promoting autophagosome maturation (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Required in the stress fiber dynamics and cell migration (By similarity).

8355:p4ha3.L
gene id: 8355:p4ha3.L
uniprot id: A0A8J1MCA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

8355:LOC108706752
gene id: 8355:LOC108706752
uniprot id: A0A8J1M1N9
names: Similarity
messages: Belongs to the CCSER family.

8355:mfsd14bl.L
gene id: 8355:mfsd14bl.L
uniprot id: A0A1L8HYK1
uniprot id: A0A974I415
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

8355:tmed9.L
gene id: 8355:tmed9.L
uniprot id: A0A1L8GXX7
uniprot id: A0A974DBE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:lamb4.L
gene id: 8355:lamb4.L
uniprot id: A0A8J0UJ01
uniprot id: A0A8J0URD8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

8355:ahsa1.L
gene id: 8355:ahsa1.L
uniprot id: A0A974C867
uniprot id: Q6GQ65
names: Similarity
messages: Belongs to the AHA1 family.

8355:slc41a2.S
gene id: 8355:slc41a2.S
uniprot id: A0A1L8GUV3
uniprot id: A0A974HRG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

8355:hrh4.f7.L
gene id: 8355:hrh4.f7.L
uniprot id: A0A8J0VN75
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:polr2j.L
gene id: 8355:polr2j.L
uniprot id: A0A974HW26
uniprot id: Q5M778
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.
messages: Nucleus

8355:bsx.L
gene id: 8355:bsx.L
uniprot id: A0A1L8FLC4
uniprot id: A0A974CFN8
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108718898
gene id: 8355:LOC108718898
uniprot id: A0A1L8FW71
uniprot id: A0A974CLV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

8355:scarb2.S
gene id: 8355:scarb2.S
uniprot id: Q5XH33
names: Similarity
messages: Belongs to the CD36 family.

8355:LOC121398870
gene id: 8355:LOC121398870
uniprot id: A0A8J1LXS7
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:cplane2.L
gene id: 8355:cplane2.L
uniprot id: A0A1L8FP55
uniprot id: A0A974CHG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.
messages: cilium basal body

8355:scnn1d.L
gene id: 8355:scnn1d.L
uniprot id: Q7SZG4
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Membrane
messages: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.

8355:cplx1.S
gene id: 8355:cplx1.S
uniprot id: A0A8J0U2F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

8355:LOC108717425
gene id: 8355:LOC108717425
uniprot id: A0A8J1KUY4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:otop3.L
gene id: 8355:otop3.L
uniprot id: A0A8J1LVV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

8355:LOC108699039
gene id: 8355:LOC108699039
uniprot id: A0A8J0TMD8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:map3k13.L
gene id: 8355:map3k13.L
uniprot id: A7J1T2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm
messages: May have a role in the JNK signaling pathway.
messages: Membrane

8355:nr1h2.S
gene id: 8355:nr1h2.S
uniprot id: A0A1L8FHB7
uniprot id: A0A974CD39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

8355:ext2.S
gene id: 8355:ext2.S
uniprot id: A0A1L8GDK6
uniprot id: A0A974HL24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane

8355:LOC108704460
gene id: 8355:LOC108704460
uniprot id: A0A8J1M2T1
uniprot id: A0A8J1M3K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8355:LOC108704403
gene id: 8355:LOC108704403
uniprot id: A0A8J0TWQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8355:LOC121395553
gene id: 8355:LOC121395553
uniprot id: A0A1L8FLR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

8355:LOC121397032
gene id: 8355:LOC121397032
uniprot id: A0A8J1KUR7
uniprot id: A0A8J1KW79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

8355:msi1.S
gene id: 8355:msi1.S
uniprot id: A0A1L8HQ70
uniprot id: A0A8J0TSY5
uniprot id: A0A8J1LM96
uniprot id: A0A974DUQ8
uniprot id: A0A974DWF8
uniprot id: Q5U4T5
uniprot id: Q91807
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Musashi family.
messages: Cytoplasm

8355:hspa1a.L
gene id: 8355:hspa1a.L
uniprot id: A0A8J0TA12
uniprot id: A0A8J0TDB8
names: Similarity
messages: Belongs to the heat shock protein 70 family.

8355:or6s1.S
gene id: 8355:or6s1.S
uniprot id: A0A1L8HPR7
uniprot id: A0A974I1E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:frem3.L
gene id: 8355:frem3.L
uniprot id: A0A310TMV5
uniprot id: A0A974GZJ3
names: Similarity
messages: Belongs to the FRAS1 family.

8355:adgrl3.S
gene id: 8355:adgrl3.S
uniprot id: A0A8J1M1Z0
uniprot id: A0A8J1M1Z5
uniprot id: A0A8J1M1Z6
uniprot id: A0A8J1M201
uniprot id: A0A8J1M202
uniprot id: A0A8J1M206
uniprot id: A0A8J1M213
uniprot id: A0A8J1M218
uniprot id: A0A8J1M222
uniprot id: A0A8J1M226
uniprot id: A0A8J1M352
uniprot id: A0A8J1M357
uniprot id: A0A8J1M363
uniprot id: A0A8J1M3W3
uniprot id: A0A8J1M3W9
uniprot id: A0A8J1M3X6
names: Subcellular Location Annotation
messages: Membrane

8355:pax5.L
gene id: 8355:pax5.L
uniprot id: A0A8J1MNT9
uniprot id: A0A974DZT5
uniprot id: Q9YH95
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: First detected in mid-neurula embryos in the folding neural tube. With the completion of neurulation, expression becomes localized to the midbrain/hindbrain boundary (MHB) till at least stage 40. Expression is absent from regions adjacent to the MHB. In tailbuds, weakly and transiently expressed in the developing otic vesicle from stage 21 to stage 27.
messages: Nucleus
messages: Probable transcription factor.

8355:apob.L
gene id: 8355:apob.L
uniprot id: Q7SYX5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:tpte2.S
gene id: 8355:tpte2.S
uniprot id: A0A1L8HAD6
uniprot id: A0A974DJY6
names: Similarity
messages: Belongs to the PTEN phosphatase protein family.

8355:cacna1a.S
gene id: 8355:cacna1a.S
uniprot id: A0A8J1MSN8
uniprot id: A0A8J1MSP3
uniprot id: A0A8J1MSQ0
uniprot id: A0A8J1MSV3
uniprot id: A0A8J1MSV7
uniprot id: A0A8J1MSW2
uniprot id: A0A8J1MTQ9
uniprot id: A0A8J1MTR6
uniprot id: A0A8J1MTS1
uniprot id: A0A8J1MU18
uniprot id: A0A8J1MU23
uniprot id: A0A8J1MU29
uniprot id: A0A8J1MV00
uniprot id: A0A8J1MV05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane

8355:ube2n.L
gene id: 8355:ube2n.L
uniprot id: A0A1L8GYC6
uniprot id: A0A974DBD8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8355:scn3b.S
gene id: 8355:scn3b.S
uniprot id: A0A1L8FFJ8
uniprot id: A0A974CCA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

8355:LOC108702489
gene id: 8355:LOC108702489
uniprot id: A0A1L8EKR0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8355:LOC108706552
gene id: 8355:LOC108706552
uniprot id: A0A1L8HKY9
uniprot id: A0A974DRP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

8355:dvl1.L
gene id: 8355:dvl1.L
uniprot id: A0A8J0T2L8
uniprot id: A0A8J0T931
uniprot id: A0A8J1L8K1
names: Similarity
messages: Belongs to the DSH family.

8355:zdhhc17.S
gene id: 8355:zdhhc17.S
uniprot id: A0A1L8GUE9
uniprot id: A0A8J0UXM2
uniprot id: A0A974DAV3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:tpp2.L
gene id: 8355:tpp2.L
uniprot id: Q6GQZ3
names: Similarity
messages: Belongs to the peptidase S8 family.

8355:LOC108719991
gene id: 8355:LOC108719991
uniprot id: A0A1L8FRM2
uniprot id: A0A8J0VQF0
uniprot id: A0A8J1L1S1
uniprot id: A0A8J1L1T2
uniprot id: A0A8J1L1T7
uniprot id: A0A8J1L3C3
uniprot id: A0A8J1L4H2
uniprot id: A0A974CJX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

8355:LOC108702804
gene id: 8355:LOC108702804
uniprot id: A0A8J1LYV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

8355:LOC108709442
gene id: 8355:LOC108709442
uniprot id: A0A1L8H716
uniprot id: A0A8J1MDX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

8355:LOC108705319
gene id: 8355:LOC108705319
uniprot id: A0A8J1KQV6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:slc4a7.S
gene id: 8355:slc4a7.S
uniprot id: A0A1L8FRH8
uniprot id: A0A8J0VM81
uniprot id: A0A8J0VQC9
uniprot id: A0A8J1L1Q1
uniprot id: A0A974CK82
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

8355:LOC108697992
gene id: 8355:LOC108697992
uniprot id: A0A1L8FHB2
uniprot id: A0A974CCX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

8355:pigb.S
gene id: 8355:pigb.S
uniprot id: Q4V7R2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family. PIGB subfamily.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly (By similarity).

8355:adamts3.L
gene id: 8355:adamts3.L
uniprot id: A0A8J1N0F7
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8355:irx1.L
gene id: 8355:irx1.L
uniprot id: A0A974CPS7
uniprot id: Q9YGK8
names: Caution
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Acts early in neural plate development to induce expression of some but not all proneural genes, and specify a neural precursor state. Also up-regulates repressors that prevent neuronal differentiation. Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes. Acts primarily as a transcriptional repressor during neural development, and binds to the bmp4 promoter to repress gene expression and thus mediate down-regulation of bmp4 by wnt signaling. Controls multiple processes through bmp4-repression including neural plate development, neural crest specification and Spemann organizer development. Involved in the specification of the preplacodal field at the anterior border of the neural plate. Regulates the genetic cascade of interactions that are necessary for positioning the isthmus organizer and the formation of the midbrain-hindbrain boundary. Required during at least two stages of pronephros kidney development; during neurula stages, maintains transcription of key renal genes to define the size and identity of the pronephric anlage, probably in part through regulation of bmp-signaling. Subsequently required for proper formation of the intermediate tubule segment of the pronephros. Acts principally as a transcriptional activator during pronephros development.
messages: Although PubMed:17875669 show that irx1 is dispensable for pronephric kidney development, PubMed:18715948 show that irx1 is required for formation of the pronephros.
messages: Belongs to the TALE/IRO homeobox family.
messages: By wnt signaling. Mutually antagonizes bmp4 signaling. Inhibited in the neural plate by foxd5. The anterior limit of expression at the future border between the prethalamus and thalamus is defined by mutual repression with the anterior repressor fezf2, and also by arx. Induced by retinoic acid (RA) during kidney development.
messages: Expressed early in neural differentiation in the neural plate, and expression continues in the neural tube after neural fold closure. Expressed in the presumptive midbrain territory. Also expressed in the prospective neural crest and the preplacodal field, anterior to the neural plate. Strongly expressed in the profundal placode and weakly expressed in the trigeminal placode. Also expressed in the mesoderm in the Spemann organizer from the start of gastrulation, and subsequently in its derivatives; namely in the notochord as well as in the somites of stage 25 embryos, and the somites and notochord of tailbud embryos. Also expressed in specific and overlapping dynamic patterns with irx2 and irx3 during pronephric kidney development. Renal expression begins in the dorsal region of the pronephric anlage at mid neurula stage and continues to at least tailbud stages where expression is confined to the intermediate tubule segment IT1. Renal expression is maintained at tadpole stages.
messages: Nucleus

8355:fam227a.L
gene id: 8355:fam227a.L
uniprot id: A0A8J1MYU9
names: Similarity
messages: Belongs to the FAM227 family.

8355:lhx9.L
gene id: 8355:lhx9.L
uniprot id: A0A1L8GN79
uniprot id: A0A1L8GNA9
uniprot id: A0A8J1MXC7
uniprot id: A0A8J1MZU4
uniprot id: A0A974D6T2
uniprot id: A0A974D6W6
names: Subcellular Location Annotation
messages: Nucleus

8355:taf2.L
gene id: 8355:taf2.L
uniprot id: A0A8J0VLL3
uniprot id: A0A8J0VPH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF2 family.
messages: Nucleus

8355:slc39a9.L
gene id: 8355:slc39a9.L
uniprot id: Q6NRM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Cell membrane
messages: Mitochondrion
messages: Nucleus
messages: Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Regulates intracellular zinc level, resulting in the enhancement of AKT1 and MAPK3/MAPK1 (Erk1/2) phosphorylation in response to the BCR activation (By similarity). Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1 (By similarity). Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process (By similarity).
messages: perinuclear region
messages: trans-Golgi network membrane

8355:cfl2.S
gene id: 8355:cfl2.S
uniprot id: A0A8J0TF99
uniprot id: A0A8J1LNM0
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

8355:scrn2.S
gene id: 8355:scrn2.S
uniprot id: A0A1L8EKV8
uniprot id: A0A8J1LXJ7
uniprot id: Q5XH17
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

8355:cldn8.1.S
gene id: 8355:cldn8.1.S
uniprot id: A0A1L8H5A1
uniprot id: A0A974DI54
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8355:lamtor4.S
gene id: 8355:lamtor4.S
uniprot id: A0A8J0U587
uniprot id: A0A8J1MTU1
names: Similarity
messages: Belongs to the LAMTOR4 family.

8355:grpel2.L
gene id: 8355:grpel2.L
uniprot id: A0A974HSN7
uniprot id: Q5U571
names: Similarity
messages: Belongs to the GrpE family.

8355:nodal.L
gene id: 8355:nodal.L
uniprot id: O13048
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TGF-beta family.
messages: By dorsal-mesoderm inducing signals including vegt and other nodal-related proteins. By sox17.
messages: Cooperation and regulatory loops of multiple nodals are essential for mesendoderm patterning in early embryos. Plays a role in mesoderm formation and may be required for neural development.
messages: During blastula stages, expressed in the endoderm at a higher level dorsally than ventrally. Expressed in the deep cells of the Spemann organizer at the gastrula stage. Expressed in the notochord (a derivative of the organizer) and neural tube during the neural stages.
messages: Expressed zygotically. First expressed at the midblastula transition (MBT).
messages: Homodimer; disulfide-linked.
messages: Secreted

8355:bmp4.S
gene id: 8355:bmp4.S
uniprot id: A0A8J0TPC4
uniprot id: A0A974H594
uniprot id: B7ZPR8
uniprot id: P30885
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Expressed both maternally and zygotically. Expressed at a low level maternally with expression levels increasing rapidly after stage 9. Expression is maintained throughout development and in a range of adult tissues including the ovary and testis.
messages: Homodimer; disulfide-linked (By similarity). Forms heterodimers with the TGF-beta family member derriere. Part of a complex consisting of twsg1 and chrd. Interacts with tsku (PubMed:16319115).
messages: Posterior-ventralizing factor in Xenopus mesoderm induction. Induces posteroventral mesoderm and counteracts dorsalizing signals such as activin.
messages: extracellular matrix

8355:or11l1.18.L
gene id: 8355:or11l1.18.L
uniprot id: Q9I8B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108716137
gene id: 8355:LOC108716137
uniprot id: A0A8J1KNH3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

8355:ptpn3.S
gene id: 8355:ptpn3.S
uniprot id: A0A974CK80
uniprot id: Q6GPK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

8355:LOC100037001
gene id: 8355:LOC100037001
uniprot id: A0A8J0THX9
uniprot id: A0A8J0TPK2
names: Similarity
messages: Belongs to the KHDC4 family.

8355:fam135b.L
gene id: 8355:fam135b.L
uniprot id: Q641I1
names: Similarity
messages: Belongs to the FAM135 family.

8355:lactb2.L
gene id: 8355:lactb2.L
uniprot id: Q5XGR8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.
messages: Mitochondrion matrix

8355:ablim2.L
gene id: 8355:ablim2.L
uniprot id: A0A8J1M6Y8
uniprot id: A0A8J1M6Z2
uniprot id: A0A8J1M714
uniprot id: A0A8J1M715
uniprot id: A0A8J1M734
uniprot id: A0A8J1M737
uniprot id: A0A8J1M742
uniprot id: A0A8J1M773
uniprot id: A0A8J1M836
uniprot id: A0A8J1M8W0
uniprot id: A0A8J1M8X0
uniprot id: A0A8J1M8X5
uniprot id: Q66IQ2
names: Subcellular Location Annotation
messages: Cytoplasm

8355:tshz3.L
gene id: 8355:tshz3.L
uniprot id: A0A1L8GL93
uniprot id: A0A974D5M4
uniprot id: A0SNQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.
messages: Nucleus

8355:LOC121399388
gene id: 8355:LOC121399388
uniprot id: A0A8J1M4D7
names: Similarity
messages: Belongs to the cyclin family.

8355:wee2.L
gene id: 8355:wee2.L
uniprot id: A0A8J1MGT9
uniprot id: P47817
names: Caution
names: Cofactor
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Binds 2 magnesium ions per subunit.
messages: Detected in egg (at protein level). Oocyte-specific maternally supplied protein. Present in immature and mature oocytes and in early (pregastrula) embryos, but not in post-gastrula embryos.
messages: Expressed only after meiosis I. Not detected in full-grown stage VI immature oocytes (arrested at prophase I) and in oocytes undergoing germinal vesicle breakdown (GVBD) or meiosis I, while it is present in oocytes from 1-1.5 hour after GVBD, or from the onset of meiosis II.
messages: Interacts with prmt5; this promotes protesomal degradation of wee2-a in the nucleus. The interaction with prmt5 is disrupted upon activation of the DNA replication checkpoint.
messages: Nucleus
messages: Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits cdk1 and acts as a key regulator of meiosis. Required to maintain meiotic arrest in oocytes by phosphorylating cdk1 at 'Tyr-15', which inhibits cdk1 activity and prevents meiotic reentry. Negative regulator of mitosis. Involved in the mitotic DNA replication checkpoint.
messages: Subject to proteasomal degradation in the nucleus.
messages: Was initially assigned as wee1 (PubMed:7749193). However, it corresponds to the meiosis-specific protein WEE2 in mammals.
messages: cytosol

8355:txnip.L
gene id: 8355:txnip.L
uniprot id: Q6DED2
names: Similarity
messages: Belongs to the arrestin family.

8355:LOC108710529
gene id: 8355:LOC108710529
uniprot id: A0A1L8H4J3
uniprot id: A0A974DHA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:smg7.S
gene id: 8355:smg7.S
uniprot id: A0A1L8GG27
uniprot id: A0A8J0V2V4
uniprot id: A0A8J0V6D3
uniprot id: A0A8J0V755
uniprot id: A0A8J0V7Q0
uniprot id: A0A974CZI3
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in nonsense-mediated mRNA decay.

8355:pacsin1.S
gene id: 8355:pacsin1.S
uniprot id: A0A974HVE2
uniprot id: Q6AX65
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytosol
messages: ruffle membrane
messages: synaptosome

8355:snrpg.L
gene id: 8355:snrpg.L
uniprot id: A0A1L8H1N9
uniprot id: A0A8J0UW78
uniprot id: A0A974DF54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

8355:LOC108697057
gene id: 8355:LOC108697057
uniprot id: A0A8J0T4B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:tom1.S
gene id: 8355:tom1.S
uniprot id: Q6DDZ2
names: Similarity
messages: Belongs to the TOM1 family.

8355:LOC108708480
gene id: 8355:LOC108708480
uniprot id: A0A8J0UIU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
messages: Belongs to the sulfotransferase 6 family.
messages: Membrane

8355:snap25.L
gene id: 8355:snap25.L
uniprot id: A0A974CVD2
uniprot id: Q640W4
uniprot id: Q8AXM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion.
messages: synaptosome

8355:sco1.L
gene id: 8355:sco1.L
uniprot id: A0A1L8EV00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCO1/2 family.
messages: Mitochondrion inner membrane

8355:LOC108719346
gene id: 8355:LOC108719346
uniprot id: A0A1L8HSD5
uniprot id: A0A974DW39
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:fxyd1.S
gene id: 8355:fxyd1.S
uniprot id: A2VDB1
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the FXYD family.
messages: Cell membrane
messages: Membrane
messages: T-tubule
messages: caveola
messages: sarcolemma

8355:ampd1.L
gene id: 8355:ampd1.L
uniprot id: A0A1L8HE24
uniprot id: A0A974DN95
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

8355:kcnk1.S
gene id: 8355:kcnk1.S
uniprot id: Q3KQ34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Endosome
messages: Membrane
messages: Perikaryon
messages: Recycling endosome
messages: Synaptic cell membrane
messages: Vesicle
messages: dendrite

8355:ccnp.L
gene id: 8355:ccnp.L
uniprot id: A0A1L8F8V1
uniprot id: A0A8J1LIF9
uniprot id: A0A974H7Q2
names: Similarity
messages: Belongs to the cyclin family.

8355:abca8.L
gene id: 8355:abca8.L
uniprot id: A0A1L8ETB2
uniprot id: A0A974BXR6
names: Subcellular Location Annotation
messages: Membrane

8355:naa38.S
gene id: 8355:naa38.S
uniprot id: A0A8J0U1P5
uniprot id: Q6NU60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of naa35, naa38 and naa30.
messages: Cytoplasm

8355:LOC108717776
gene id: 8355:LOC108717776
uniprot id: A0A1L8G1T9
uniprot id: A0A8J0VKD5
uniprot id: A0A8J1KSK6
uniprot id: A0A974HH15
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8355:LOC108702641
gene id: 8355:LOC108702641
uniprot id: A0A1L8ELN5
uniprot id: A0A974H0R3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

8355:mapk6.S
gene id: 8355:mapk6.S
uniprot id: A0A1L8GSY5
uniprot id: A0A974HQU7
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

8355:LOC121393962
gene id: 8355:LOC121393962
uniprot id: A0A8J1KSL7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108719490
gene id: 8355:LOC108719490
uniprot id: A0A1L8G0E3
uniprot id: A0A974HH47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

8355:arsa.1.S
gene id: 8355:arsa.1.S
uniprot id: A0A974CQZ4
uniprot id: Q6AX40
names: Similarity
messages: Belongs to the sulfatase family.

8355:LOC108712389
gene id: 8355:LOC108712389
uniprot id: A0A8J1MS06
uniprot id: A0A8J1MTD4
uniprot id: A0A8J1MUB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

8355:rpa3.S
gene id: 8355:rpa3.S
uniprot id: A0A974CIK6
uniprot id: Q6AZP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

8355:tfap2c.L
gene id: 8355:tfap2c.L
uniprot id: A0A1L8ESV4
uniprot id: A0A8J0TKL5
uniprot id: A0A8J0TT54
uniprot id: A0A974BX41
names: Similarity
messages: Belongs to the AP-2 family.

8355:cdr2l.S
gene id: 8355:cdr2l.S
uniprot id: A0A1L8EMW1
uniprot id: A0A974H137
names: Similarity
messages: Belongs to the CDR2 family.

8355:cox10.L
gene id: 8355:cox10.L
uniprot id: Q0IH15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiA prenyltransferase family.
messages: Converts protoheme IX and farnesyl diphosphate to heme O.
messages: Membrane
messages: Mitochondrion membrane

8355:LOC121401078
gene id: 8355:LOC121401078
uniprot id: A0A8J1MIQ3
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC108713018
gene id: 8355:LOC108713018
uniprot id: A0A1L8GTM2
uniprot id: A0A8J1MRB8
uniprot id: A0A8J1MRC2
uniprot id: A0A8J1MRH4
uniprot id: A0A8J1MRI6
uniprot id: A0A8J1MSC4
uniprot id: A0A8J1MSC9
uniprot id: A0A8J1MSE0
uniprot id: A0A8J1MSM3
uniprot id: A0A8J1MSN3
uniprot id: A0A8J1MTL4
uniprot id: A0A8J1MTL9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

8355:mrpl53.L
gene id: 8355:mrpl53.L
uniprot id: Q66IS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL53 family.
messages: Mitochondrion

8355:bola1.L
gene id: 8355:bola1.L
uniprot id: A0A1L8FBX4
uniprot id: A0A8J0TK02
uniprot id: A0A974H8X1
names: Similarity
messages: Belongs to the BolA/IbaG family.

8355:sh3bgrl3.L
gene id: 8355:sh3bgrl3.L
uniprot id: A0A8J0UD26
names: Similarity
messages: Belongs to the SH3BGR family.

8355:slc5a7.S
gene id: 8355:slc5a7.S
uniprot id: A0A8J1MFG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

8355:pitpnm3.S
gene id: 8355:pitpnm3.S
uniprot id: A0A8J1MD51
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

8355:atxn2.S
gene id: 8355:atxn2.S
uniprot id: A0A8J0U271
uniprot id: A0A8J0U982
uniprot id: A0A8J0UAB1
uniprot id: A0A8J0UAJ0
uniprot id: A0A8J0UD03
names: Similarity
messages: Belongs to the ataxin-2 family.

8355:pcdhac2.L
gene id: 8355:pcdhac2.L
uniprot id: A0A8J0UHL0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

8355:gbe1.S
gene id: 8355:gbe1.S
uniprot id: Q5XG45
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

8355:slc15a2.L
gene id: 8355:slc15a2.L
uniprot id: A0A8J0TSN0
uniprot id: Q7SY87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

8355:plscr4.S
gene id: 8355:plscr4.S
uniprot id: A0A8J1MU97
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

8355:nfe2l1.L
gene id: 8355:nfe2l1.L
uniprot id: A0A1L8ES08
uniprot id: A0A8J0TTX7
uniprot id: A0A974H272
names: Similarity
messages: Belongs to the bZIP family. CNC subfamily.

8355:LOC108710308
gene id: 8355:LOC108710308
uniprot id: A0A8J1MW84
uniprot id: A0A8J1MWA1
uniprot id: A0A8J1MWB2
uniprot id: A0A8J1MWB8
uniprot id: A0A8J1MWE0
uniprot id: A0A8J1MWI2
uniprot id: A0A8J1MWI7
uniprot id: A0A8J1MWJ2
uniprot id: A0A8J1MWJ4
uniprot id: A0A8J1MWK4
uniprot id: A0A8J1MWM1
uniprot id: A0A8J1MWM6
uniprot id: A0A8J1MWN7
uniprot id: A0A8J1MWQ7
uniprot id: A0A8J1MWR9
uniprot id: A0A8J1MWV7
uniprot id: A0A8J1MXD3
uniprot id: A0A8J1MXE9
uniprot id: A0A8J1MXH6
uniprot id: A0A8J1MXI2
uniprot id: A0A8J1MXK3
uniprot id: A0A8J1MXM0
uniprot id: A0A8J1MXN5
uniprot id: A0A8J1MXT2
uniprot id: A0A8J1MXT8
uniprot id: A0A8J1MXV0
uniprot id: A0A8J1MXY0
uniprot id: A0A8J1MXY6
uniprot id: A0A8J1MXZ7
uniprot id: A0A8J1MY27
uniprot id: A0A8J1MY52
uniprot id: A0A8J1MY91
uniprot id: A0A8J1MYB0
uniprot id: A0A8J1MYP7
uniprot id: A0A8J1MYQ3
uniprot id: A0A8J1MYQ9
uniprot id: A0A8J1MYU8
uniprot id: A0A8J1MYW0
uniprot id: A0A8J1MYZ2
uniprot id: A0A8J1MZ54
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

8355:LOC121399093
gene id: 8355:LOC121399093
uniprot id: A0A8J1LZE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

8355:LOC108696816
gene id: 8355:LOC108696816
uniprot id: A0A1L8FP12
uniprot id: A0A974HDB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

8355:smg1.S
gene id: 8355:smg1.S
uniprot id: A0A1L8EQ71
uniprot id: A0A8J1LWT8
uniprot id: A0A8J1LYN1
uniprot id: A0A974H1N8
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

8355:mettl2b.L
gene id: 8355:mettl2b.L
uniprot id: A0A8J1LRZ6
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

8355:LOC108696093
gene id: 8355:LOC108696093
uniprot id: A0A8J0T9C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

8355:lamb3.S
gene id: 8355:lamb3.S
uniprot id: A0A1L8H6F1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:stra6.L
gene id: 8355:stra6.L
uniprot id: A0A1L8H009
uniprot id: A0A974DED4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:ipo13.S
gene id: 8355:ipo13.S
uniprot id: A0A1L8GFL1
uniprot id: A0A8J0V2H5
uniprot id: A0A8J0V6T9
uniprot id: A0A974CZ87
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the importin beta family.
messages: Cytoplasm
messages: Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.
messages: Nucleus

8355:get3.L
gene id: 8355:get3.L
uniprot id: A0A1L8H300
uniprot id: A0A974HU98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homodimer.

8355:XB5850668.L
gene id: 8355:XB5850668.L
uniprot id: A0A1L8FNN9
uniprot id: A0A974CIA9
uniprot id: A1L3M6
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8355:tspan17.L
gene id: 8355:tspan17.L
uniprot id: A0A1L8GXX3
uniprot id: A0A8J0UPA6
uniprot id: A0A974DC87
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:spic.S
gene id: 8355:spic.S
uniprot id: Q6DCY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8355:LOC108699038
gene id: 8355:LOC108699038
uniprot id: A0A8J1LJV9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:tlr9.L
gene id: 8355:tlr9.L
uniprot id: A0A8J0V7L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

8355:stx7.L
gene id: 8355:stx7.L
uniprot id: Q7ZWP6
names: Similarity
messages: Belongs to the syntaxin family.

8355:tdrd3.L
gene id: 8355:tdrd3.L
uniprot id: Q6NRP6
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of mRNA stress granules.
messages: Cytoplasm
messages: Nucleus
messages: Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1.
messages: The Tudor domain specifically recognizes and binds asymmetric dimethylation of histone H3 'Arg-17' (H3R17me2a) and histones H4 'Arg-3', 2 tags for epigenetic transcriptional activation.

8355:aldh5a1.L
gene id: 8355:aldh5a1.L
uniprot id: A0A1L8FY56
uniprot id: A0A974CQI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
messages: Homotetramer.
messages: Mitochondrion

8355:LOC108710549
gene id: 8355:LOC108710549
uniprot id: A0A8J0USJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:ccne1.L
gene id: 8355:ccne1.L
uniprot id: A0A974D3U9
uniprot id: P50756
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family.
messages: Belongs to the cyclin family. Cyclin E subfamily.
messages: Essential for the control of the cell cycle at the G1/S (start) transition.
messages: Interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.
messages: Nucleus
messages: Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway.

8355:rnf145.L
gene id: 8355:rnf145.L
uniprot id: A0A8J0UM97
uniprot id: A0A8J1MHN6
uniprot id: A0A974DCH6
uniprot id: Q6GM95
names: Subcellular Location Annotation
messages: Membrane

8355:XB5836416.L
gene id: 8355:XB5836416.L
uniprot id: Q66KP8
names: Similarity
messages: Belongs to the aldo/keto reductase family.

8355:tubb2b.L
gene id: 8355:tubb2b.L
uniprot id: A0A1L8FXS6
uniprot id: A0A974CNB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

8355:plppr1.L
gene id: 8355:plppr1.L
uniprot id: A0A1L8HXU5
uniprot id: A0A974DZS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

8355:cyp1d1.S
gene id: 8355:cyp1d1.S
uniprot id: A0A1L8HP70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

8355:rtp3b.S
gene id: 8355:rtp3b.S
uniprot id: A0A1L8G3W8
uniprot id: A0A974CSA4
names: Subcellular Location Annotation
messages: Cytoplasmic ribonucleoprotein granule

8355:LOC108696771
gene id: 8355:LOC108696771
uniprot id: A0A1L8FNL4
uniprot id: A0A8J1L7P1
names: Function
names: Subcellular Location Annotation
messages: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: ruffle

8355:foxr1.L
gene id: 8355:foxr1.L
uniprot id: A0A1L8FLF7
uniprot id: A0A8J0T233
uniprot id: Q3BJS0
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TTC36 family.
messages: Expressed maternally. Expression levels decrease from gastrulation until the onset of neurulation (stage 15), when expression is absent.
messages: Nucleus
messages: Ubiquitously expressed in early cleavage stage and gastrula stage embryos.

8355:cacybp.L
gene id: 8355:cacybp.L
uniprot id: A0A1L8GMJ1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
messages: Nucleus

8355:shbg.S
gene id: 8355:shbg.S
uniprot id: A0A8J1MQC1
uniprot id: A0A8J1MRG5
uniprot id: Q5U524
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:MGC84691
gene id: 8355:MGC84691
uniprot id: A0A8J0TVC4
uniprot id: A0A8J1LR67
uniprot id: A0A8J1LS68
uniprot id: Q6DKB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

8355:krt19.S
gene id: 8355:krt19.S
uniprot id: A0A8J0TY67
uniprot id: Q05AX6
names: Similarity
messages: Belongs to the intermediate filament family.

8355:lsm14a.S
gene id: 8355:lsm14a.S
uniprot id: A0A8J0TVZ9
uniprot id: Q8AVJ2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LSM14 family.
messages: Component of a ribonucleoprotein (RNP) complex, at least composed of lsm14a/rap55a, ybx2/frgy2, ddx6/Xp54 and eif4enif1/4E-T. Also forms a complex with prmt1 independently of ybx2/frgy2. Interacts with ddx6/Xp54 but does not appear to directly bind ybx2/frgy2. Different translationally-repressed mRNP complexes probably exist that contain either lsm14a/rap55a or lsm14b/rap55b depending on the developmental stage (By similarity).
messages: Cytoplasm
messages: P-body
messages: Phosphorylated.
messages: RNA-binding component of messenger ribonucleoprotein complexes (mRNPs), storage particles that mask maternal mRNAs from the translational apparatus during oocyte maturation. Acts as a repressor of mRNA translation. Probably involved in the storage of translationally inactive mRNAs in the cytoplasm in order to prevent their degradation.
messages: Stress granule
messages: The RGG repeats are required for interaction with ddx6/Xp54 and accumulation in ribonucleoprotein complexes.

8355:il1rapl1.S
gene id: 8355:il1rapl1.S
uniprot id: A0A8J1MDT2
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

8355:leo1.L
gene id: 8355:leo1.L
uniprot id: A0A1L8H0G4
uniprot id: A0A974DD27
names: Similarity
messages: Belongs to the LEO1 family.

8355:ocstamp.L
gene id: 8355:ocstamp.L
uniprot id: A0A1L8ESH5
names: Subcellular Location Annotation
messages: Membrane

8355:msx2.L
gene id: 8355:msx2.L
uniprot id: A0A1L8GXR7
uniprot id: A0A974DC42
names: Subcellular Location Annotation
messages: Nucleus

8355:pms2.L
gene id: 8355:pms2.L
uniprot id: A0A8J0TX93
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

8355:mtfr1l.S
gene id: 8355:mtfr1l.S
uniprot id: A0A974DHN5
uniprot id: Q4V7T5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

8355:nim1k.L
gene id: 8355:nim1k.L
uniprot id: A0A1L8I2G5
uniprot id: A0A974I5H9
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:ipo9.S
gene id: 8355:ipo9.S
uniprot id: A0A1L8H7C4
uniprot id: A0A974DJ17
names: Subcellular Location Annotation
messages: Cytoplasm

8355:LOC108717342
gene id: 8355:LOC108717342
uniprot id: A0A1L8I1J8
uniprot id: A0A8J1L6M5
uniprot id: A0A974E283
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

8355:LOC121402023
gene id: 8355:LOC121402023
uniprot id: A0A310TM41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:ada.L
gene id: 8355:ada.L
uniprot id: A0A8J1LQA8
uniprot id: A0A8J1LQF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasmic vesicle lumen

8355:cdhr1.L
gene id: 8355:cdhr1.L
uniprot id: Q6B457
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in photoreceptor cells of the outer nuclear layer of the retina and in the pinal gland.
messages: Expressed in the retina 3 days post-fertilization (hpf).
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein.

8355:cdknx.L
gene id: 8355:cdknx.L
uniprot id: A0A974CH21
uniprot id: Q91646
names: Similarity
messages: Belongs to the CDI family.

8355:eny2.S
gene id: 8355:eny2.S
uniprot id: A0A1L8FTN9
uniprot id: A0A974CKJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2). Component of the SAGA transcription coactivator-HAT complex. Within the SAGA complex, participates to a subcomplex of SAGA called the DUB module (deubiquitination module).
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
messages: nucleoplasm

8355:LOC108713766
gene id: 8355:LOC108713766
uniprot id: A0A1L8GIT5
uniprot id: A0A974HN60
names: Function
names: Similarity
messages: Belongs to the SPSB family.
messages: May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

8355:ikzf5.L
gene id: 8355:ikzf5.L
uniprot id: Q6NRM0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 'Pegasus' was the winged horse in Greek mythology.
messages: Belongs to the Ikaros C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Probably self-associates.
messages: Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence.

8355:elavl3.L
gene id: 8355:elavl3.L
uniprot id: A0A8J0TYJ5
uniprot id: A0A8J0U5Q8
uniprot id: A0A8J0U6Y7
uniprot id: A0A8J1MGW5
uniprot id: A0A8J1MHU3
uniprot id: A0A974BR73
uniprot id: Q91584
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
names: Tissue Specificity
messages: Belongs to the RRM elav family.
messages: By bHLH transcription factors atoh7/ath5 and neurod1/neuroD.
messages: Expressed by late gastrula stage (stage 11).
messages: Expression is neural-specific in both embryos and adults. Expressed from neurula stage onwards in primary motor-, inter- and sensory-neurons. Expressed in the closing neural tube and motor neurons of stage 18 embryos, and primarily in the ventricular zone and dorsal region of the tailbud and adult brain. Expressed from stage 26 onwards in the differentiating ganglion cell layer of the retina, extending to the inner nuclear layer at later stages.
messages: RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs. May also bind poly-A tracts via RRM 3. May be involved in neuronal differentiation and maintenance (By similarity).
messages: RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in target mRNAs. RRM 3 binds to poly-A mRNA sequences (By similarity).

8355:h1-10.S
gene id: 8355:h1-10.S
uniprot id: Q2VPN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8355:LOC121398263
gene id: 8355:LOC121398263
uniprot id: A0A8J1LUB8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:micos10.L
gene id: 8355:micos10.L
uniprot id: A0A974HCZ9
uniprot id: A4FVF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

8355:slc6a17.S
gene id: 8355:slc6a17.S
uniprot id: A0A1L8H6Y7
uniprot id: A0A974DHL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8355:alms1.S
gene id: 8355:alms1.S
uniprot id: A0A8J1M0J2
uniprot id: A0A8J1M0L2
uniprot id: A0A8J1M0N8
uniprot id: A0A8J1M1R2
uniprot id: A0A8J1M2K2
names: Subcellular Location Annotation
messages: centrosome

8355:LOC108710440
gene id: 8355:LOC108710440
uniprot id: A0A1L8H3U5
uniprot id: A0A974DGX2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:rexo4.L
gene id: 8355:rexo4.L
uniprot id: Q2TAR2
names: Similarity
messages: Belongs to the REXO4 family.

8355:LOC108717138
gene id: 8355:LOC108717138
uniprot id: A0A8J0VDK8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:c8g.S
gene id: 8355:c8g.S
uniprot id: A0A8J0TQL1
names: Subcellular Location Annotation
messages: Secreted

8355:cdca7l.L
gene id: 8355:cdca7l.L
uniprot id: A0A8J0VIY5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:crygbl.6.S
gene id: 8355:crygbl.6.S
uniprot id: A0A8J0U519
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:LOC100036900
gene id: 8355:LOC100036900
uniprot id: A0A1L8FI98
uniprot id: A0A974CE81
uniprot id: A1L2N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

8355:stat6.L
gene id: 8355:stat6.L
uniprot id: A0A1L8HI20
uniprot id: Q5U256
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

8355:ddx28.L
gene id: 8355:ddx28.L
uniprot id: A0A1L8GKB9
uniprot id: A0A974D4N2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family.
messages: Cytoplasm
messages: Nucleus
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

8355:tprg1l.S
gene id: 8355:tprg1l.S
uniprot id: A0A1L8FGH9
uniprot id: A0A974HAB8
names: Similarity
messages: Belongs to the TPRG1 family.

8355:pdyn.L
gene id: 8355:pdyn.L
uniprot id: Q6Y2X1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin.
messages: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Leumorphin has a typical opioid activity and may have anti-apoptotic effect.
messages: Secreted

8355:LOC121393575
gene id: 8355:LOC121393575
uniprot id: A0A1L8GCE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8355:LOC121401416
gene id: 8355:LOC121401416
uniprot id: A0A8J1KZA3
names: Similarity
messages: Belongs to the HARBI1 family.

8355:pias2.L
gene id: 8355:pias2.L
uniprot id: A0A8J0U2N8
uniprot id: A0A8J0UAS2
uniprot id: A0A8J0UAZ0
uniprot id: A0A8J0UDH3
uniprot id: Q6IRN4
names: Similarity
messages: Belongs to the PIAS family.

8355:LOC121401329
gene id: 8355:LOC121401329
uniprot id: A0A8J1MJS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC121401325
gene id: 8355:LOC121401325
uniprot id: A0A8J1MJS3
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108707238
gene id: 8355:LOC108707238
uniprot id: A0A1L8HR89
uniprot id: A0A8J0U2K5
uniprot id: A0A974I252
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

8355:ambn.S
gene id: 8355:ambn.S
uniprot id: Q6Y4V3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ameloblastin family.
messages: Involved in the mineralization and structural organization of enamel.
messages: extracellular matrix

8355:LOC108703446
gene id: 8355:LOC108703446
uniprot id: A0A8J0U1S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108709041
gene id: 8355:LOC108709041
uniprot id: A0A1L8HBI6
uniprot id: A0A974DMA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8355:eef1d.S
gene id: 8355:eef1d.S
uniprot id: A0A8J0VIP8
uniprot id: A0A8J0VKZ2
uniprot id: A0A8J0VL72
uniprot id: A0A8J0VM42
uniprot id: A0A8J0VPT2
uniprot id: P29693
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

8355:vps53.L
gene id: 8355:vps53.L
uniprot id: A0A1L8HG35
uniprot id: A0A8J1M900
uniprot id: A0A974DN79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

8355:uba6.L
gene id: 8355:uba6.L
uniprot id: A0A8J1MZ58
uniprot id: A0A8J1N0R2
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

8355:dmbx1.S
gene id: 8355:dmbx1.S
uniprot id: A0A1L8GFS8
uniprot id: A0A8J1KJ76
uniprot id: A0A974CZC4
names: Subcellular Location Annotation
messages: Nucleus

8355:mtmr1.L
gene id: 8355:mtmr1.L
uniprot id: A0A1L8F7L2
uniprot id: A0A8J0TIL7
uniprot id: A0A8J0TJE4
uniprot id: A0A8J0TKA7
uniprot id: A0A974C6X6
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

8355:LOC108717922
gene id: 8355:LOC108717922
uniprot id: A0A1L8G2T9
uniprot id: A0A8J1KUU6
uniprot id: A0A8J1KWB3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8355:cdca7.L
gene id: 8355:cdca7.L
uniprot id: A0A8J0TQ65
uniprot id: A2BDC5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:cdh22.S
gene id: 8355:cdh22.S
uniprot id: A0A1L8EMF1
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane

8355:cachd1.S
gene id: 8355:cachd1.S
uniprot id: A0A1L8GFF1
uniprot id: A0A8J1KIZ8
uniprot id: A0A974CZC1
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

8355:adcy5.S
gene id: 8355:adcy5.S
uniprot id: A0A1L8ENI2
uniprot id: A0A8J1LY59
uniprot id: A0A974H1F3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

8355:prr5.L
gene id: 8355:prr5.L
uniprot id: A0A8J0UN24
uniprot id: A0A8J1MGP4
uniprot id: A0A8J1MH90
uniprot id: Q8AVJ1
names: Function
names: Similarity
messages: Belongs to the PROTOR family.
messages: Subunit of TORC2, which regulates cell growth and survival in response to hormonal signals.

8355:LOC108710417
gene id: 8355:LOC108710417
uniprot id: A0A8J1MKN1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC121400407
gene id: 8355:LOC121400407
uniprot id: A0A8J1MC95
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:polr2j.S
gene id: 8355:polr2j.S
uniprot id: A0A974HW26
uniprot id: Q5M778
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.
messages: Nucleus

8355:ccna1.S
gene id: 8355:ccna1.S
uniprot id: Q6GME9
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

8355:LOC108700827
gene id: 8355:LOC108700827
uniprot id: A0A1L8ES96
uniprot id: A0A974BX83
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:bmp7.2.S
gene id: 8355:bmp7.2.S
uniprot id: A0A1L8GT31
uniprot id: A0A974D943
names: Similarity
messages: Belongs to the TGF-beta family.

8355:rpl35a.S
gene id: 8355:rpl35a.S
uniprot id: Q7SZB0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

8355:znf750.L
gene id: 8355:znf750.L
uniprot id: Q32N19
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription factor involved in epidermis differentiation.

8355:cndp1.L
gene id: 8355:cndp1.L
uniprot id: Q6PA54
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

8355:dpt.S
gene id: 8355:dpt.S
uniprot id: A0A1L8H6D2
uniprot id: A0A974HV87
names: Similarity
messages: Belongs to the dermatopontin family.

8355:ca11.S
gene id: 8355:ca11.S
uniprot id: A0A1L8FGR6
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

8355:slc4a11.L
gene id: 8355:slc4a11.L
uniprot id: A0A8J1MMP7
uniprot id: A0A8J1MNM9
uniprot id: A0A8J1MPS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Membrane

8355:taf5.L
gene id: 8355:taf5.L
uniprot id: B1WBA4
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

8355:chd1.S
gene id: 8355:chd1.S
uniprot id: A0A1L8HR49
uniprot id: A0A1L8HR66
uniprot id: A0A8J0UAT5
uniprot id: A0A974DWJ8
uniprot id: A0A974DXE7
names: Subcellular Location Annotation
messages: Nucleus

8355:serpina3.L
gene id: 8355:serpina3.L
uniprot id: A0A1L8F9L8
uniprot id: Q5U539
names: Similarity
messages: Belongs to the serpin family.

8355:prkg1.S
gene id: 8355:prkg1.S
uniprot id: A0A1L8FE28
uniprot id: A0A8J0TF03
uniprot id: A0A974CAY3
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

8355:capn8.1.S
gene id: 8355:capn8.1.S
uniprot id: A0A8J1KS88
uniprot id: A0A8J1KS94
names: Similarity
messages: Belongs to the peptidase C2 family.

8355:LOC398653
gene id: 8355:LOC398653
uniprot id: A0A974HXU4
uniprot id: Q6DJI6
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

8355:cavin2.L
gene id: 8355:cavin2.L
uniprot id: A0A1L8EX60
uniprot id: A0A974C091
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

8355:lamp1.L
gene id: 8355:lamp1.L
uniprot id: Q6DCR6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

8355:slc16a13.L
gene id: 8355:slc16a13.L
uniprot id: A0A974GZ58
uniprot id: Q5M7D0
names: Subcellular Location Annotation
messages: Membrane

8355:slc25a18.S
gene id: 8355:slc25a18.S
uniprot id: A0A8J1MQY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8355:LOC121399407
gene id: 8355:LOC121399407
uniprot id: A0A8J1M2P7
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:ldhb.S
gene id: 8355:ldhb.S
uniprot id: A0A1L8GQX2
uniprot id: A0A974D8E2
uniprot id: Q7SYU9
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

8355:aurka.S
gene id: 8355:aurka.S
uniprot id: Q91819
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: Interacts with kif2c and kif11.
messages: Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression (By similarity). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (By similarity). Phosphorylates numerous target proteins (By similarity). Important for microtubule formation and/or stabilization (By similarity).
messages: Phosphorylated (By similarity). Autophosphorylated on a serine residue (By similarity).
messages: centrosome
messages: spindle pole

8355:LOC108712438
gene id: 8355:LOC108712438
uniprot id: A0A1L8HWF9
uniprot id: A0A974DYH2
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

8355:pnck.L
gene id: 8355:pnck.L
uniprot id: Q7T2H4
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:ptger1.L
gene id: 8355:ptger1.L
uniprot id: A0A1L8H2L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108708524
gene id: 8355:LOC108708524
uniprot id: A0A1L8HHL3
uniprot id: A0A8J0UEZ3
uniprot id: A0A8J0UG94
uniprot id: A0A974DP95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8355:eva1a.S
gene id: 8355:eva1a.S
uniprot id: A0A1L8G557
uniprot id: A0A974CSU0
names: Similarity
messages: Belongs to the EVA1 family.

8355:chst10.L
gene id: 8355:chst10.L
uniprot id: A0A974DNM3
uniprot id: Q6GNS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules (By similarity).
messages: Golgi apparatus membrane
messages: Membrane

8355:gab3.S
gene id: 8355:gab3.S
uniprot id: A0A1L8F2S6
uniprot id: A0A8J1LQ53
names: Similarity
messages: Belongs to the GAB family.

8355:ppp6r3.L
gene id: 8355:ppp6r3.L
uniprot id: A0A8J0UT15
uniprot id: A0A8J0UY07
uniprot id: A0A8J0UZ72
uniprot id: A0A8J0UZ77
uniprot id: Q6NRI0
names: Function
names: Similarity
messages: Belongs to the SAPS family.
messages: Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit (By similarity).

8355:LOC108716355
gene id: 8355:LOC108716355
uniprot id: A0A1L8GA24
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

8355:bix1.3.L
gene id: 8355:bix1.3.L
uniprot id: A0A1L8G718
uniprot id: A0A974CTK2
uniprot id: Q9YHW3
names: Subcellular Location Annotation
messages: Nucleus

8355:gfod2.L
gene id: 8355:gfod2.L
uniprot id: A0A974D4K7
uniprot id: Q7ZY75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Gfo/Idh/MocA family.
messages: Promotes matrix assembly.
messages: extracellular matrix

8355:krt78.7.S
gene id: 8355:krt78.7.S
uniprot id: A0A1L8HA75
uniprot id: A0A974DJ61
names: Similarity
messages: Belongs to the intermediate filament family.

8355:LOC108695731
gene id: 8355:LOC108695731
uniprot id: A0A8J0T6L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:ggps1.S
gene id: 8355:ggps1.S
uniprot id: A0A1L8G2P4
uniprot id: A0A974HHB6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

8355:chrng.L
gene id: 8355:chrng.L
uniprot id: A0A8J0U5W7
uniprot id: A0JMU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8355:LOC108700821
gene id: 8355:LOC108700821
uniprot id: A0A1L8ES57
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

8355:LOC121393332
gene id: 8355:LOC121393332
uniprot id: A0A8J1KML5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8355:cxcl10.L
gene id: 8355:cxcl10.L
uniprot id: A0A1L8HVA1
uniprot id: A0A974DZE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

8355:nkx2-6.L
gene id: 8355:nkx2-6.L
uniprot id: Q9W6H4
names: Subcellular Location Annotation
messages: Nucleus

8355:dao.L
gene id: 8355:dao.L
uniprot id: A0A1L8HZZ7
uniprot id: A0A1L8HZZ9
uniprot id: A0A974E1C8
uniprot id: Q4QR47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

8355:astl2f.S
gene id: 8355:astl2f.S
uniprot id: A0A8J0V126
uniprot id: A0A8J1KJF4
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:tspan36.L
gene id: 8355:tspan36.L
uniprot id: Q6P7J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8355:LOC108711754
gene id: 8355:LOC108711754
uniprot id: A0A1L8H3B6
uniprot id: A0A974HUD2
names: Similarity
messages: Belongs to the FMO family.

8355:nkx3-2.L
gene id: 8355:nkx3-2.L
uniprot id: A0A1L8HTD2
uniprot id: A0A974DWD0
names: Subcellular Location Annotation
messages: Nucleus

8355:rps7.L
gene id: 8355:rps7.L
uniprot id: A0A1L8G577
uniprot id: A0A974CSK5
uniprot id: A0A974CUH0
uniprot id: P02362
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS7 family.
messages: Component of the small ribosomal subunit.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for rRNA maturation.
messages: Cytoplasm
messages: Nucleus
messages: centrosome

8355:gsdme.L
gene id: 8355:gsdme.L
uniprot id: Q6DCC3
names: Similarity
messages: Belongs to the gasdermin family.

8355:LOC108708909
gene id: 8355:LOC108708909
uniprot id: A0A8J1MG10
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

8355:sars2.L
gene id: 8355:sars2.L
uniprot id: A0A1L8F928
uniprot id: A0A974C7H9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.

8355:soat1.L
gene id: 8355:soat1.L
uniprot id: A0A1L8GMV6
uniprot id: A0A8J0V1J5
uniprot id: A0A974HPK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:LOC121393440
gene id: 8355:LOC121393440
uniprot id: A0A8J1KKT7
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC108704577
gene id: 8355:LOC108704577
uniprot id: A0A8J0U7R1
uniprot id: A0A8J1MJF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Membrane

8355:LOC108700132
gene id: 8355:LOC108700132
uniprot id: A0A8J0TNH7
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

8355:rap1gds1.L
gene id: 8355:rap1gds1.L
uniprot id: A0A1L8HV82
uniprot id: A0A974DXE6
uniprot id: A0A974DYU9
uniprot id: O93614
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Endoplasmic reticulum
messages: Expressed both maternally and zygotically from oogenesis through to late embryogenesis at a constant level.
messages: Interacts with ralB (PubMed:9753634). Probably interacts with the post-translationally isoprenylated (geranyl-geranylation) forms of ral proteins. Interacts with both GDP-bound and GTP-bound forms of ralA, but interaction is much stronger with ralA-GDP (PubMed:9753634).
messages: Mitochondrion
messages: Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein.
messages: Weakly expressed in adult tissues with highest levels found in spleen, kidney, skin and A6 cells.
messages: cytosol

8355:ubl3.S
gene id: 8355:ubl3.S
uniprot id: A0A974HWT5
uniprot id: Q6GNJ9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108704392
gene id: 8355:LOC108704392
uniprot id: A0A8J1KKJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:mcee.S
gene id: 8355:mcee.S
uniprot id: Q4FZP6
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

8355:LOC121393653
gene id: 8355:LOC121393653
uniprot id: A0A8J1KMU8
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:nedd9.S
gene id: 8355:nedd9.S
uniprot id: A0A8J0U4N1
uniprot id: A0A8J1L2B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

8355:atp6v1c2.L
gene id: 8355:atp6v1c2.L
uniprot id: A0A1L8GBH8
uniprot id: A0A974HKK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

8355:XB5738351.L
gene id: 8355:XB5738351.L
uniprot id: A0A1L8H0Q0
uniprot id: A0A974HT92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

8355:LOC108700332
gene id: 8355:LOC108700332
uniprot id: A0A8J1LLB9
names: Similarity
messages: Belongs to the peptidase C1 family.

8355:LOC108719731
gene id: 8355:LOC108719731
uniprot id: A0A8J0VME8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

8355:rpl28.S
gene id: 8355:rpl28.S
uniprot id: A0A974CCT2
uniprot id: Q66KV6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL28 family.

8355:psme1.S
gene id: 8355:psme1.S
uniprot id: Q6GP09
names: Similarity
messages: Belongs to the PA28 family.

8355:LOC108717389
gene id: 8355:LOC108717389
uniprot id: A0A8J1KTX4
names: Subcellular Location Annotation
messages: Membrane

8355:agl.L
gene id: 8355:agl.L
uniprot id: A0A1L8GN75
uniprot id: A0A8J1MZR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.

8355:LOC121401511
gene id: 8355:LOC121401511
uniprot id: A0A8J1ML09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
messages: Membrane

8355:hsp90b1.S
gene id: 8355:hsp90b1.S
uniprot id: Q6PAE3
names: Similarity
messages: Belongs to the heat shock protein 90 family.

8355:oaz2.S
gene id: 8355:oaz2.S
uniprot id: Q1PPZ9
names: Similarity
messages: Belongs to the ODC antizyme family.

8355:snx18.S
gene id: 8355:snx18.S
uniprot id: Q5XGZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

8355:spin1.L
gene id: 8355:spin1.L
uniprot id: A0A8J1MAV3
uniprot id: A0A974DU20
uniprot id: Q4V7S2
names: Similarity
messages: Belongs to the SPIN/STSY family.

8355:tmem178a.S
gene id: 8355:tmem178a.S
uniprot id: A0A974CQM8
uniprot id: Q5XGU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM178 family.
messages: Endoplasmic reticulum membrane
messages: May act as a negative regulator of osteoclast differentiation.

8355:LOC121399727
gene id: 8355:LOC121399727
uniprot id: A0A8J1M848
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

8355:fzd3.L
gene id: 8355:fzd3.L
uniprot id: O42579
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Cell surface
messages: Expression restricted to the early nervous system.
messages: Low expression from cleavage stages to the end of gastrulation; increases from neurulation onward. During neurulation, first localized to the anterior neural folds. As neurulation proceeds, the expression extends to the trunk neural fold, with low levels in the posterior neural fold. At the end of neurulation, strongly expressed as a large band in the midbrain. After neural tube closure, also detected in the optic lobes and otic vesicles. During the late development, expression remains restricted to the nervous system. Detected until at least the larval stages.
messages: Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
messages: Membrane
messages: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activated by Wnt8. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner (By similarity).
messages: The FZ domain is involved in binding with Wnt ligands.

8355:ndufb4.L
gene id: 8355:ndufb4.L
uniprot id: Q3KQ78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

8355:LOC108719383
gene id: 8355:LOC108719383
uniprot id: A0A1L8FZT2
uniprot id: A0A974CR26
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108695733
gene id: 8355:LOC108695733
uniprot id: A0A1L8FIK9
uniprot id: A0A974HB79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108695850
gene id: 8355:LOC108695850
uniprot id: A0A8J0T9V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:mrpl51.L
gene id: 8355:mrpl51.L
uniprot id: A0A1L8FJ49
uniprot id: A0A8J0T0M4
uniprot id: A0A8J1L4V3
uniprot id: A0A974HB84
uniprot id: Q66KZ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins (By similarity).
messages: Mitochondrion

8355:dcaf1.S
gene id: 8355:dcaf1.S
uniprot id: A0A1L8GHG5
uniprot id: A0A8J0V3Q9
uniprot id: A0A974D305
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPRBP/DCAF1 family.
messages: Nucleus

8355:LOC121399129
gene id: 8355:LOC121399129
uniprot id: A0A1L8G0S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:chst9l.1.S
gene id: 8355:chst9l.1.S
uniprot id: A0A1L8EZS0
uniprot id: A0A974C2P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:LOC108701341
gene id: 8355:LOC108701341
uniprot id: A0A8J1LR70
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:niban2.S
gene id: 8355:niban2.S
uniprot id: A0A1L8F1S7
uniprot id: A0A974C2Z5
uniprot id: Q6GPX6
names: Similarity
messages: Belongs to the Niban family.

8355:hrh4.f3.L
gene id: 8355:hrh4.f3.L
uniprot id: A0A8J0VN72
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:LOC108716543
gene id: 8355:LOC108716543
uniprot id: A0A8J0V9R9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:rab3a.L
gene id: 8355:rab3a.L
uniprot id: A0A974DZ49
uniprot id: Q5U507
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

8355:gria3.L
gene id: 8355:gria3.L
uniprot id: A0A1L8F7A8
uniprot id: A0A8J0TE11
uniprot id: A0A8J1LE43
uniprot id: A0A974H782
uniprot id: B9V8R9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8355:cast.L
gene id: 8355:cast.L
uniprot id: Q9I9C1
names: Function
names: Similarity
messages: Belongs to the protease inhibitor I27 (calpastatin) family.
messages: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

8355:hrh4.b1.L
gene id: 8355:hrh4.b1.L
uniprot id: A0A8J1KW94
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:dtx2.L
gene id: 8355:dtx2.L
uniprot id: A0A1L8HFZ6
uniprot id: A0A8J0U773
uniprot id: A0A8J0UE26
uniprot id: A0A974HYN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

8355:LOC108695306
gene id: 8355:LOC108695306
uniprot id: A0A1L8FSZ0
uniprot id: A0A974CJZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

8355:LOC121398750
gene id: 8355:LOC121398750
uniprot id: A0A8J1LWE7
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:meis3.L
gene id: 8355:meis3.L
uniprot id: A0A974H7U0
uniprot id: Q5U4X3
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TALE/MEIS homeobox family.
messages: Caudalizing protein which is required to pattern the anterior/posterior (A/P) axis during central nervous system (CNS) formation. Inhibits anterior neural expression and acts as a transcriptional activator to induce posterior neural gene expression. Maintains a proper A/P balance required for hindbrain formation by activating the FGF/MAPK pathway, which modulates the planar cell polarity (PCP) pathway. Interacts with retinoid signaling during hindbrain patterning.
messages: In early-mid neurula stages, expressed in a single stripe in the neural plate. By neurula/early-tailbud stages, expression is localized to rhombomeres r2, r3 and r4 and the anterior spinal cord. Some ventral expression was also detected in posterior rhombomeres. Not expressed in rhombomere r1.
messages: Initially expressed at gastrula stages. Expression peaks at neurula stage, and is maintained at stable levels through tailbud stages.
messages: Nucleus

8355:wnk4.S
gene id: 8355:wnk4.S
uniprot id: A0A1L8EMC7
uniprot id: A0A974BTF3
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

8355:LOC108700895
gene id: 8355:LOC108700895
uniprot id: A0A1L8ESP7
names: Subcellular Location Annotation
messages: Membrane

8355:lipe.L
gene id: 8355:lipe.L
uniprot id: A0A8J0QD49
uniprot id: A0A8J1L3Y4
uniprot id: A0A8J1L400
uniprot id: A0A8J1L5M1
uniprot id: B3DLL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'GDXG' lipolytic enzyme family.
messages: Cell membrane
messages: Lipid droplet
messages: caveola
messages: cytosol

8355:gria3.S
gene id: 8355:gria3.S
uniprot id: A0A8J1LM64
uniprot id: A0A8J1LMB4
uniprot id: A0A8J1LNA6
uniprot id: A0A8J1LPP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8355:iqsec2.S
gene id: 8355:iqsec2.S
uniprot id: A0A1L8F1P3
uniprot id: A0A8J0TPZ0
uniprot id: A0A8J0TR08
uniprot id: A0A8J1LNF3
uniprot id: A0A8J1LPT3
uniprot id: A0A974H5B9
names: Similarity
messages: Belongs to the BRAG family.

8355:noc4l.S
gene id: 8355:noc4l.S
uniprot id: A0A8J0TV71
uniprot id: A0A8J1LNJ5
uniprot id: Q6NRQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: Nucleus membrane
messages: nucleolus

8355:timm23.L
gene id: 8355:timm23.L
uniprot id: A0A8J0U3H8
uniprot id: Q6INU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of timm23, timm17 and timm50. The complex interacts with the timm44 component of the PAM complex (By similarity).
messages: Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

8355:gtsf2.L
gene id: 8355:gtsf2.L
uniprot id: P13007
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0224 (FAM112) family.
messages: Cytoplasm
messages: Involved in oocyte maturation. It is possible that D7 is required at a certain point in the maturation process and that maturation cannot proceed beyond this point unless a threshold amount of D7 protein is provided.
messages: Its levels are highest during the first day of embryonic development and then decrease; D7 protein was not detected in adult tissues.

8355:myo1e.2.L
gene id: 8355:myo1e.2.L
uniprot id: Q2TAV1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8355:kcng2.L
gene id: 8355:kcng2.L
uniprot id: A0A1L8FY81
uniprot id: A0A974CPW6
names: Subcellular Location Annotation
messages: Membrane

8355:LOC121401258
gene id: 8355:LOC121401258
uniprot id: A0A8J1MJG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC121403015
gene id: 8355:LOC121403015
uniprot id: A0A1L8GKV8
names: Subcellular Location Annotation
messages: Cell membrane

8355:XB5884180.L
gene id: 8355:XB5884180.L
uniprot id: A0A1L8GYF7
uniprot id: A0A974DDQ2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:pitx2.S
gene id: 8355:pitx2.S
uniprot id: A0A8J0TNH4
uniprot id: A0A974DSD8
uniprot id: Q6GNM5
uniprot id: Q9PWR3
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Asymmetrically expressed in the left lateral plate mesoderm, tubular heart and early gut tube.
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: By nodal/nr-1 in the left lateral plate mesoderm.
messages: May play an important role in development and maintenance of anterior structures and mediate left-right asymmetry. Could play a role at the interface of lateral plate signaling and heart and gut morphogenesis.
messages: Nucleus

8355:gpr141.L
gene id: 8355:gpr141.L
uniprot id: A0A1L8FWZ6
uniprot id: A0A974CMG6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:grin3b.S
gene id: 8355:grin3b.S
uniprot id: A0A1L8HN96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8355:rgs9bp.S
gene id: 8355:rgs9bp.S
uniprot id: Q5XHI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RGS7BP/RGS9BP family.
messages: Membrane
messages: Regulator of G protein-coupled receptor (GPCR) signaling. Probably acts by regulating the activity of some 'R7' family protein (RGS6, RGS7, RGS9 and/or RGS11).

8355:eif1b.L
gene id: 8355:eif1b.L
uniprot id: A0A974CIY2
uniprot id: Q8QHI4
names: Similarity
messages: Belongs to the SUI1 family.

8355:ing1.S
gene id: 8355:ing1.S
uniprot id: A0A974DIC1
uniprot id: Q3L6P2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

8355:crygbl.5.S
gene id: 8355:crygbl.5.S
uniprot id: A0A8J0U519
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:LOC108699538
gene id: 8355:LOC108699538
uniprot id: A0A1L8F8M7
uniprot id: A0A974C7F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:atp6ap1.2.L
gene id: 8355:atp6ap1.2.L
uniprot id: A0A1L8F5D4
uniprot id: A0A974C5B3
names: Similarity
messages: Belongs to the vacuolar ATPase subunit S1 family.

8355:crtc3.S
gene id: 8355:crtc3.S
uniprot id: A0A1L8GSP8
uniprot id: A0A8J0V050
uniprot id: A0A974HQK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TORC family.
messages: Cytoplasm
messages: Nucleus

8355:grk6.S
gene id: 8355:grk6.S
uniprot id: A0A8J1MRC1
uniprot id: A0A974DBF9
uniprot id: Q68F06
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

8355:cyyr1.L
gene id: 8355:cyyr1.L
uniprot id: Q5HZN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYYR1 family.
messages: Membrane

8355:LOC108713150
gene id: 8355:LOC108713150
uniprot id: A0A1L8GUH6
uniprot id: A0A8J1MSV4
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.

8355:cand1.L
gene id: 8355:cand1.L
uniprot id: Q6DKM0
names: Similarity
messages: Belongs to the CAND family.

8355:cltcl1.S
gene id: 8355:cltcl1.S
uniprot id: A0A1L8HQC0
uniprot id: A0A8J0UAB5
uniprot id: A0A8J1M3F8
uniprot id: A0A974DVK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

8355:cd40lg.L
gene id: 8355:cd40lg.L
uniprot id: A0A1L8F817
uniprot id: A0A974C6Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell surface

8355:LOC108719487
gene id: 8355:LOC108719487
uniprot id: A0A1L8G0I6
uniprot id: A0A8J1L068
uniprot id: A0A8J1L1R0
uniprot id: A0A8J1L2Z7
uniprot id: A0A974HGS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tonsoku family.
messages: Chromosome

8355:trim9.L
gene id: 8355:trim9.L
uniprot id: A0A1L8F9X1
uniprot id: A0A8J0TID1
uniprot id: A0A8J0TJZ8
uniprot id: A0A8J0TKS4
uniprot id: A0A8J0TKS8
uniprot id: A0A8J1LHI0
uniprot id: A0A8J1LI07
uniprot id: A0A8J1LJV8
uniprot id: A0A974C952
names: Subcellular Location Annotation
messages: cytoskeleton

8355:XB5961849.S
gene id: 8355:XB5961849.S
uniprot id: A0A8J1LQ79
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ITPK1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.
messages: Monomer.

8355:adam12.S
gene id: 8355:adam12.S
uniprot id: A0A1L8FEF0
uniprot id: A0A974CC45
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:snap91.L
gene id: 8355:snap91.L
uniprot id: A0A1L8G9T2
uniprot id: A0A8J0V894
uniprot id: A0A8J0V899
uniprot id: A0A8J0VB84
uniprot id: A0A8J0VBS4
uniprot id: A0A8J0VCJ0
uniprot id: A0A8J1KNS9
uniprot id: A0A8J1KNT5
uniprot id: A0A8J1KNT8
uniprot id: A0A8J1KNU3
uniprot id: A0A8J1KQH1
uniprot id: A0A8J1KRW5
uniprot id: A0A8J1KRX0
uniprot id: A0A974CXG3
names: Similarity
messages: Belongs to the PICALM/SNAP91 family.

8355:adamts15.L
gene id: 8355:adamts15.L
uniprot id: A0A1L8FL13
uniprot id: A0A974HBY2
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8355:LOC108715185
gene id: 8355:LOC108715185
uniprot id: A0A8J1KNM9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:mki67.L
gene id: 8355:mki67.L
uniprot id: A0A8J1L4S6
uniprot id: A0A8J1L4S7
uniprot id: A0A8J1L4T0
uniprot id: A0A8J1L4T4
uniprot id: A0A8J1L4T5
uniprot id: A0A8J1L4T9
uniprot id: A0A8J1L4U0
uniprot id: A0A8J1L4U4
uniprot id: A0A8J1L4U5
uniprot id: A0A8J1L4U8
uniprot id: A0A8J1L4V1
uniprot id: A0A8J1L4V2
uniprot id: A0A8J1L4V7
uniprot id: A0A8J1L4W3
uniprot id: A0A8J1L4W8
uniprot id: A0A8J1L4X3
uniprot id: A0A8J1L6I6
uniprot id: A0A8J1L6J7
uniprot id: A0A8J1L6K2
uniprot id: A0A8J1L6K9
uniprot id: A0A8J1L7J6
uniprot id: A0A8J1L7K1
uniprot id: A0A8J1L7K7
uniprot id: A0A8J1L7L1
names: Subcellular Location Annotation
messages: Nucleus

8355:itfg1.S
gene id: 8355:itfg1.S
uniprot id: A0A1L8GFF8
uniprot id: A0A974D114
names: Similarity
messages: Belongs to the TIP family.

8355:cdx1.L
gene id: 8355:cdx1.L
uniprot id: A0A1L8GWE3
uniprot id: A0A974DCQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

8355:iws1.S
gene id: 8355:iws1.S
uniprot id: Q6DE96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IWS1 family.
messages: Nucleus
messages: Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts.

8355:ctnna1.L
gene id: 8355:ctnna1.L
uniprot id: A0A1L8GWT0
uniprot id: A0A974DCZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction

8355:dpysl3.S
gene id: 8355:dpysl3.S
uniprot id: A0A1L8GV71
uniprot id: A0A974HRJ8
uniprot id: O13022
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Cytoplasm
messages: Homotetramer and heterotetramer.
messages: Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.
messages: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).
messages: growth cone

8355:ssx2ip.S
gene id: 8355:ssx2ip.S
uniprot id: Q6NRK1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Involved in cell movement (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome.
messages: Belongs to the ADIP family.
messages: Expressed at M-phase onset and accumulates at microtubule minus ends.
messages: Interacts with WRAP73.
messages: adherens junction
messages: centriolar satellite

8355:ldlrap1.L
gene id: 8355:ldlrap1.L
uniprot id: Q67FQ3
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR). Also involved in the vitellogenin receptor mediated endocytosis of nutrients during oogenesis.
messages: Cytoplasm
messages: Expressed at high level during oogenesis and embryogenesis. Found at low level in the adult liver and spleen. Found at very low level in testis and heart. Not found in the oocyte vegetal cortex.
messages: Expressed throughout oogenesis. Homogeneously distributed in stages I and II oocytes and only later localized primarily to the vegetal cortex. Expressed in early stage embryos, but expression decreases during gastrulation, reaching barely detectable levels by tailbud stages.
messages: Interacts (via PID domain) with ldlr (via NPXY motif) (PubMed:12591597). Binds to soluble clathrin trimers and to the adapter protein complex 2 (AP-2, beta 2 subunit). Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Interacts with the VLDL receptor (vldlr) (By similarity). Interacts with the vitellogenin receptor (PubMed:12591597).
messages: The PID domain mediates interaction with the NPXY internalization motif of LDLR.
messages: The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction the AP-2 complex subunit AP2B1.

8355:LOC108718221
gene id: 8355:LOC108718221
uniprot id: A0A1L8G4Y4
uniprot id: A0A8J1KUG3
uniprot id: A0A8J1KXG7
uniprot id: A0A974CSZ6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:cyp2d6.S
gene id: 8355:cyp2d6.S
uniprot id: Q6DCR5
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:cebpb.S
gene id: 8355:cebpb.S
uniprot id: Q9YH08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

8355:hyal4.L
gene id: 8355:hyal4.L
uniprot id: A0A1L8GZ06
uniprot id: A0A974DDT3
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

8355:pth2r.S
gene id: 8355:pth2r.S
uniprot id: A0A1L8EPU1
uniprot id: A0A974BV28
names: Subcellular Location Annotation
messages: Membrane

8355:ctu2
gene id: 8355:ctu2
uniprot id: A0A8J0U637
uniprot id: Q08B12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTU2/NCS2 family.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ctu1/atpbd3 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position.

8355:tbpl2.L
gene id: 8355:tbpl2.L
uniprot id: A0A974C8L6
uniprot id: Q5UE94
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TBP family.
messages: Expressed both maternally and zygotically. Abundant in oocytes and expressed in embryos at a lower level, dropping between embryonic stages 6.5 and 12.
messages: Expression is restricted to the gonads, and is higher in the ovary than the testis.
messages: Nucleus
messages: TATA box-binding transcription factor. Members of the TBP family are differentially required to regulate transcription and development during early embryogenesis. Required for gastrulation. Regulates a large subset of genes that are ventrally expressed. Binds to a subset of promoters.

8355:ankrd13b.S
gene id: 8355:ankrd13b.S
uniprot id: A0A1L8H4W0
uniprot id: A0A8J0UJ67
uniprot id: A0A8J1MC28
uniprot id: A0A8J1MD35
uniprot id: A0A974DFU5
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

8355:tnrc6b.S
gene id: 8355:tnrc6b.S
uniprot id: A0A1L8GH02
uniprot id: A0A8J1KJQ7
uniprot id: A0A8J1KJQ8
uniprot id: A0A8J1KJR2
uniprot id: A0A8J1KJS1
uniprot id: A0A8J1KJS5
uniprot id: A0A8J1KLF0
uniprot id: A0A974D2S8
names: Similarity
messages: Belongs to the GW182 family.

8355:elmo1.L
gene id: 8355:elmo1.L
uniprot id: A0A974CMG2
uniprot id: Q498J3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

8355:ajap1.L
gene id: 8355:ajap1.L
uniprot id: A0A1L8FMG7
uniprot id: A0A1L8FMH3
uniprot id: A0A8J1L708
uniprot id: A0A974CG28
uniprot id: A0A974CHK3
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108704606
gene id: 8355:LOC108704606
uniprot id: A0A8J0U538
uniprot id: A0A8J0U5Q1
uniprot id: A0A8J1LVW6
uniprot id: A0A8J1LXN3
names: Similarity
messages: Belongs to the SAPAP family.

8355:LOC108704800
gene id: 8355:LOC108704800
uniprot id: A0A8J1LHR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

8355:rbm5.L
gene id: 8355:rbm5.L
uniprot id: A0A8J0UYP6
uniprot id: A0A974D7Q0
uniprot id: A0JMV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM5/RBM10 family.
messages: Component of the spliceosome A complex (also known as the prespliceosome). Appears to dissociate from the spliceosome upon formation of the spliceosome B complex (also known as the precatalytic spliceosome), in which the heterotrimeric U4/U6.U5 snRNPs are bound (By similarity).
messages: Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron (By similarity).
messages: Nucleus

8355:kcnj1.S
gene id: 8355:kcnj1.S
uniprot id: A0A1L8FFR6
uniprot id: A0A974HA31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

8355:purg.L
gene id: 8355:purg.L
uniprot id: A0A1L8HW89
uniprot id: A0A8J0UUV8
uniprot id: A0A974E0L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

8355:LOC108712603
gene id: 8355:LOC108712603
uniprot id: A0A8J0UVI0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

8355:smc3.L
gene id: 8355:smc3.L
uniprot id: Q8AW91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC3 subfamily.
messages: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.
messages: Nucleus
messages: centromere

8355:slc6a5.L
gene id: 8355:slc6a5.L
uniprot id: A0A8J1MXC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8355:tbcb.S
gene id: 8355:tbcb.S
uniprot id: A0A974C470
uniprot id: Q3KPK1
names: Similarity
messages: Belongs to the TBCB family.

8355:eps8.L
gene id: 8355:eps8.L
uniprot id: Q6NU33
names: Similarity
messages: Belongs to the EPS8 family.

8355:sdha.L
gene id: 8355:sdha.L
uniprot id: Q6PA58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.
messages: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

8355:nav1.L
gene id: 8355:nav1.L
uniprot id: A0A1L8HET2
uniprot id: A0A8J1M8D5
uniprot id: A0A8J1M8D6
uniprot id: A0A8J1M8J1
uniprot id: A0A974DQ32
names: Similarity
messages: Belongs to the Nav/unc-53 family.

8355:LOC121397593
gene id: 8355:LOC121397593
uniprot id: Q98SP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-beta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

8355:zic5.S
gene id: 8355:zic5.S
uniprot id: A0A974DJ37
uniprot id: B7ZPU8
uniprot id: Q9IB89
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: At blastula and early gastrula stage (stages 9-10.25), expressed weakly throughout the ectoderm. At the late gastrula stage (stages 11.5-13), expression is restricted to the prospective neural fold region and anterior neural plate border region. Expression becomes enhanced in the prospective midbrain and hindbrain region at the late gastrula stage. Expression in the neural plate border region continues in the neurula stage with expression in the anterior region more enhanced. Expression represents the neural plate edges and part of the neural fold. In the tailbud stages expression is restricted to the eyes, dorsal brain and the posterior part of the dorsal spinal cord. In the brain, expression is higher in the mesencephalon and rhombencephalon.
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: By FGF-signaling. By snai1/snail. By zic1, zic2, zic3 and zic5.
messages: Expressed both maternally and zygotically. Expression increases from stage 11 (late gastrula), when the neural crest is induced, through to the neurula and tailbud stages.
messages: May bind to DNA (By similarity). Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Does not induce anterior neural tissue.
messages: Nucleus

8355:cops9.L
gene id: 8355:cops9.L
uniprot id: A0A1L8GBE1
uniprot id: A0A974HK66
names: Similarity
messages: Belongs to the CSN9 family.

8355:traf3.L
gene id: 8355:traf3.L
uniprot id: A0A1L8F9Z2
uniprot id: A0A8J1LI34
uniprot id: A0A974C895
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

8355:LOC108707647
gene id: 8355:LOC108707647
uniprot id: A0A1L8HJX7
uniprot id: A0A974DQQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

8355:arhgap35.L
gene id: 8355:arhgap35.L
uniprot id: Q6NU25
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: N-terminal part (1-266) has GTPase activity. Required for proper cellular localization.
messages: Nucleus
messages: Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity).
messages: The pG1 pseudoGTPase domain does not bind GTP.
messages: cilium basal body

8355:emx2.L
gene id: 8355:emx2.L
uniprot id: A0A974CE59
uniprot id: Q6GMD8
names: Subcellular Location Annotation
messages: Nucleus

8355:pcnx2.L
gene id: 8355:pcnx2.L
uniprot id: A0A8J1KN56
uniprot id: A0A8J1KN62
uniprot id: A0A8J1KN68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

8355:dkk2.S
gene id: 8355:dkk2.S
uniprot id: A0A1L8HM80
uniprot id: A0A974DTY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

8355:slc66a1l.S
gene id: 8355:slc66a1l.S
uniprot id: A0A1L8G471
uniprot id: A0A974CTZ4
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108695758
gene id: 8355:LOC108695758
uniprot id: A0A8J0T8T6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:ghsr.S
gene id: 8355:ghsr.S
uniprot id: A0A8J0VG48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:tom1l1.L
gene id: 8355:tom1l1.L
uniprot id: A0A8J0TRE8
uniprot id: A0A8J0TSH6
uniprot id: Q8AVF2
names: Similarity
messages: Belongs to the TOM1 family.

8355:zfyve9.L
gene id: 8355:zfyve9.L
uniprot id: Q9YHB9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane

8355:lipa.L
gene id: 8355:lipa.L
uniprot id: A0A974HBG3
uniprot id: Q3KQ76
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

8355:LOC108712462
gene id: 8355:LOC108712462
uniprot id: A0A8J0UNB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:fut11.S
gene id: 8355:fut11.S
uniprot id: A9UMP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

8355:LOC108719140
gene id: 8355:LOC108719140
uniprot id: A0A1L8FY22
uniprot id: A0A974CNR4
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

8355:best4.S
gene id: 8355:best4.S
uniprot id: A0A1L8GFV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

8355:LOC108713132
gene id: 8355:LOC108713132
uniprot id: A0A1L8GUF5
uniprot id: A0A974HRP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

8355:noct.L
gene id: 8355:noct.L
uniprot id: P79942
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CCR4/nocturin family.
messages: Binds 2 magnesium ions, but the ions are only loosely bound to the protein.
messages: Cytoplasm
messages: Expressed only in the photoreceptors of the retina. Expression is controlled by the retinal circadian clock.
messages: Mitochondrion
messages: Nucleus
messages: Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (By similarity). Shows a small preference for NADPH over NADP(+) (By similarity). Component of the circadian clock or downstream effector of clock function (PubMed:12573214). Exhibits a high amplitude circadian rhythm with maximal levels in early evening (PubMed:12573214). In constant darkness or constant light, the amplitude of the rhythm decreases (PubMed:12573214).
messages: Was initially shown to have low deadenylase activity that was lost when the metal-binding Glu was mutated (PubMed:12573214). Later studies showed that the purified protein lacked deadenylase activity (By similarity). Was subsequently shown to act as a phosphatase (By similarity).
messages: perinuclear region

8355:nfil3.L
gene id: 8355:nfil3.L
uniprot id: Q66J36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. NFIL3 subfamily.
messages: Cytoplasm
messages: Homodimer (By similarity). Binds DNA as a dimer (By similarity).
messages: May act as a transcriptional regulator of a number of proteins of the circadian clock.
messages: Nucleus

8355:dusp9.L
gene id: 8355:dusp9.L
uniprot id: A0A8J0U4S4
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

8355:xv2r1.L
gene id: 8355:xv2r1.L
uniprot id: Q767K3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:tbx18.L
gene id: 8355:tbx18.L
uniprot id: G9B8Q3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8355:uox.L
gene id: 8355:uox.L
uniprot id: A0A8J0UYT8
uniprot id: A0A974D439
uniprot id: Q6P700
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
messages: Peroxisome

8355:lnpep.L
gene id: 8355:lnpep.L
uniprot id: Q5U5D5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

8355:ccni2.S
gene id: 8355:ccni2.S
uniprot id: A0A1L8GV84
uniprot id: A0A974DBT4
names: Similarity
messages: Belongs to the cyclin family.

8355:rpl14.S
gene id: 8355:rpl14.S
uniprot id: A0A974HDS3
uniprot id: Q6NTR4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

8355:six4.L
gene id: 8355:six4.L
uniprot id: A0A8J0TCG0
uniprot id: A0A8J0TK91
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC121401150
gene id: 8355:LOC121401150
uniprot id: A0A1L8GVZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcitonin family.
messages: Secreted

8355:tent2.S
gene id: 8355:tent2.S
uniprot id: Q641A1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.
messages: Component of a complex at least composed of cpeb1, cpsf1, tent2/gld2, pabpc1/ePAB, parn and sympk. Following oocyte maturation, parn is expelled from the complex. Interacts with rbfox2 and sympk.
messages: Cytoplasm
messages: Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs during oocyte maturation. Plays a central role during oocyte maturation by mediating polyadenylation of dormant mRNAs, which contain 5'AAUAAA-3' sequence in their 3'UTR. In immature oocytes, polyadenylation of poly(A) tails is counteracted by the ribonuclease parn. During maturation parn is excluded from the ribonucleoprotein complex, allowing poly(A) elongation and activation of mRNAs. May not play a role in replication-dependent histone mRNA degradation (By similarity).
messages: Present in oocytes.

8355:smagp.L
gene id: 8355:smagp.L
uniprot id: A0A1L8HI84
uniprot id: A0A974DQ00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAGP family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane

8355:gata1.S
gene id: 8355:gata1.S
uniprot id: A0A1L8F426
uniprot id: A0A8J1LLH7
uniprot id: A0A974C4J8
uniprot id: P23768
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in the developing ventral blood island, and in both tadpole and adult erythrocytes.
messages: Expressed zygotically by embryonic stage 11 (mid-gastrula).
messages: Nucleus
messages: Transcription factor that acts synergistically with tal1/scl and lmo2 to specify embryonic dorsal mesoderm to a hematopoietic fate.

8355:LOC108713158
gene id: 8355:LOC108713158
uniprot id: A0A8J0URG3
uniprot id: A0A8J0UXW1
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

8355:idh2.L
gene id: 8355:idh2.L
uniprot id: A0A1L8H0U2
uniprot id: A0A974DD96
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

8355:LOC108710673
gene id: 8355:LOC108710673
uniprot id: A0A1L8H4F0
uniprot id: A0A974DG17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:strada.L
gene id: 8355:strada.L
uniprot id: A0A1L8ESD1
uniprot id: A0A8J0TSB1
uniprot id: A0A8J1LVV7
uniprot id: A0A974H2C1
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

8355:anxa2.L
gene id: 8355:anxa2.L
uniprot id: P24801
names: Developmental Stage
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Adult brain, heart, striated muscle, liver, kidney, and very high levels in skin.
messages: Belongs to the annexin family.
messages: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.
messages: It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.
messages: Tetramer of 2 light chains (p10 proteins) and 2 heavy chains (p36 proteins).
messages: Throughout oogenesis and in mature eggs. Constant levels during early embryogenesis, but decrease at 8h. After midblastula transition, the steady state level increases substantially.
messages: basement membrane

8355:slc39a1.L
gene id: 8355:slc39a1.L
uniprot id: A0A1L8FDA8
uniprot id: A0A974CAG3
names: Subcellular Location Annotation
messages: Membrane

8355:ppp1r1c.L
gene id: 8355:ppp1r1c.L
uniprot id: A0A1L8EWM0
uniprot id: A0A8J0TTL8
uniprot id: A0A8J1LQ85
uniprot id: Q3KQ02
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

8355:LOC108702178
gene id: 8355:LOC108702178
uniprot id: A0A1L8EL38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:hnrnpa1.S
gene id: 8355:hnrnpa1.S
uniprot id: A0A8J0UGK1
uniprot id: Q7ZX33
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:sncb.L
gene id: 8355:sncb.L
uniprot id: A0A974DDP3
uniprot id: Q5U4S4
names: Similarity
messages: Belongs to the synuclein family.

8355:LOC108703107
gene id: 8355:LOC108703107
uniprot id: A0A1L8EQC9
uniprot id: A0A974BUW2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

8355:cnnm4.S
gene id: 8355:cnnm4.S
uniprot id: A0A8J1MQP7
uniprot id: A0A8J1MRJ8
uniprot id: A0A8J1MRT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Cell membrane
messages: Membrane
messages: Metal transporter.

8355:XB5799637.L
gene id: 8355:XB5799637.L
uniprot id: A0A1L8FJ96
uniprot id: A0A8J0TD17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8355:btbd10.S
gene id: 8355:btbd10.S
uniprot id: A0A974CY13
uniprot id: Q4V7H9
names: Subcellular Location Annotation
messages: Cytoplasm

8355:gna13.L
gene id: 8355:gna13.L
uniprot id: A0A1L8EV46
uniprot id: A0A974BY56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

8355:cdkl1.S
gene id: 8355:cdkl1.S
uniprot id: A0A1L8F0A6
uniprot id: A0A974C1U2
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:rps25.S
gene id: 8355:rps25.S
uniprot id: A0A974CFN4
uniprot id: Q6DJJ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

8355:grin2d.L
gene id: 8355:grin2d.L
uniprot id: A0A1L8FNL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8355:LOC121398072
gene id: 8355:LOC121398072
uniprot id: A0A1L8G0S2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:ldlrad2.L
gene id: 8355:ldlrad2.L
uniprot id: A0A1L8FP74
uniprot id: A0A974CHD2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108700067
gene id: 8355:LOC108700067
uniprot id: A0A1L8F2D9
uniprot id: A0A8J0TGP7
uniprot id: A0A8J0TPF0
uniprot id: A0A8J0TQE1
uniprot id: A0A974C3B0
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8355:med14.S
gene id: 8355:med14.S
uniprot id: A0A8J1MD74
uniprot id: A0A8J1MDP5
uniprot id: A0A8J1MF39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 14 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8355:LOC121401303
gene id: 8355:LOC121401303
uniprot id: A0A8J1MJP9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:kcnk7.L
gene id: 8355:kcnk7.L
uniprot id: A0A974H8C5
uniprot id: Q4V7J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Endosome
messages: Membrane
messages: Perikaryon
messages: Recycling endosome
messages: Synaptic cell membrane
messages: Vesicle
messages: dendrite

8355:LOC121400030
gene id: 8355:LOC121400030
uniprot id: A0A8J1M9I0
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC121399398
gene id: 8355:LOC121399398
uniprot id: A0A8J1M2L7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANP32 family.
messages: Multifunctional protein that is involved in the regulation of many processes.
messages: Nucleus

8355:dctn5.S
gene id: 8355:dctn5.S
uniprot id: Q6DJF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.
messages: cytoskeleton

8355:LOC121402273
gene id: 8355:LOC121402273
uniprot id: A0A8J1MSH7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:LOC108709050
gene id: 8355:LOC108709050
uniprot id: A0A8J1MG60
names: Subcellular Location Annotation
messages: Membrane

8355:eif2a.S
gene id: 8355:eif2a.S
uniprot id: A0A1L8G4H4
uniprot id: A0A8J0VD90
uniprot id: A0A974CS53
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

8355:smim12.S
gene id: 8355:smim12.S
uniprot id: A0A974HVY9
uniprot id: A1L2P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM12 family.
messages: Membrane

8355:LOC108698949
gene id: 8355:LOC108698949
uniprot id: A0A1L8F8P6
uniprot id: A0A974C7H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:rbm24.L
gene id: 8355:rbm24.L
uniprot id: Q6GQD3
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Expressed both maternally and zygotically (PubMed:10842088). Zygotic transcription is initiated in the early gastrula embryo in paraxial mesoderm that is fated to give rise to somites (PubMed:10842088). During the course of gastrulation and neurulation, it is expressed in somitic paraxial mesoderm is centered within the myoD expression domain (PubMed:10842088). Expressed in developing somites at larval stages (PubMed:25217815). As development proceeds it is also expressed in the cardiac primordium and the lens vesicle (PubMed:10842088, PubMed:25217815). Expressed in hypaxial migrating cells and branchiomeric cranial muscles (PubMed:25217815). In the heart expression is confined to the myocardium (PubMed:10842088).
messages: Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation. Plays a major role in pre-mRNA alternative splicing regulation. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation. Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing. Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes. Plays a role in the regulation of mRNA stability and mRNA translation to which it is bound. Involved in myogenic differentiation by regulating myog levels (PubMed:20338237). Binds to a huge amount of mRNAs. Required for embryonic heart development, sarcomer and M-band formation in striated muscles (PubMed:20338237).
messages: Nucleus
messages: The RRM domain is necessary for mRNA stability and mRNA translation regulation.
messages: Up-regulated by the myogenic factor myoD during gastrulation.

8355:klc1.L
gene id: 8355:klc1.L
uniprot id: A0A1L8FA06
uniprot id: A0A8J0TCA7
uniprot id: A0A8J0TK37
uniprot id: A0A8J0TK41
uniprot id: A0A974C846
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

8355:LOC108699315
gene id: 8355:LOC108699315
uniprot id: A0A8J0TJV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8355:camp1.L
gene id: 8355:camp1.L
uniprot id: A0A1L8FUY1
uniprot id: A0A974CNB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Secreted

8355:cntn1.S
gene id: 8355:cntn1.S
uniprot id: A0A974D8C4
uniprot id: O93250
names: Similarity
messages: Belongs to the immunoglobulin superfamily. Contactin family.

8355:dnajb12.S
gene id: 8355:dnajb12.S
uniprot id: A0A974CBR2
uniprot id: Q6GND5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:slc1a3.S
gene id: 8355:slc1a3.S
uniprot id: A0A1L8HRR7
uniprot id: A0A974DWI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

8355:gja5.L
gene id: 8355:gja5.L
uniprot id: A0A1L8HC88
uniprot id: A0A974DKK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8355:LOC121393950
gene id: 8355:LOC121393950
uniprot id: A0A8J1KQC5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:krt12.2.L
gene id: 8355:krt12.2.L
uniprot id: A0A974BWC7
uniprot id: E3WF12
names: Similarity
messages: Belongs to the intermediate filament family.

8355:LOC108706101
gene id: 8355:LOC108706101
uniprot id: A0A8J0U7B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:ahcy.S
gene id: 8355:ahcy.S
uniprot id: A0A974H0Q5
uniprot id: O93477
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (By similarity). Binds copper ions (By similarity).
messages: Cytoplasm
messages: Homotetramer.

8355:ercc1.L
gene id: 8355:ercc1.L
uniprot id: A0A1L8FKK3
uniprot id: A0A974CGD6
uniprot id: A0A974HC57
uniprot id: Q7ZYE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERCC1/RAD10/SWI10 family.
messages: Nucleus

8355:adprh.S
gene id: 8355:adprh.S
uniprot id: Q66IX9
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

8355:LOC108702495
gene id: 8355:LOC108702495
uniprot id: A0A1L8EKQ1
uniprot id: A0A8J1M142
uniprot id: A0A974BSF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

8355:inpp4a.S
gene id: 8355:inpp4a.S
uniprot id: A0A1L8H8X5
uniprot id: A0A8J0UD47
uniprot id: A0A8J0UP09
uniprot id: A0A8J1MEL1
uniprot id: A0A8J1MEL6
uniprot id: A0A8J1MEM1
uniprot id: A0A8J1MF40
uniprot id: A0A8J1MFI8
uniprot id: A0A8J1MGE2
uniprot id: A0A974DKL6
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

8355:nlgn2.L
gene id: 8355:nlgn2.L
uniprot id: A0A1L8H4F1
uniprot id: A0A8J1MNJ0
uniprot id: A0A974HUP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

8355:LOC108720086
gene id: 8355:LOC108720086
uniprot id: A0A1L8FS97
uniprot id: A0A974CJA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

8355:LOC108707151
gene id: 8355:LOC108707151
uniprot id: A0A8J0UCX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

8355:nova2.L
gene id: 8355:nova2.L
uniprot id: A0A8J1LFE5
uniprot id: Q6GPZ4
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PTBP2; the interaction is direct.
messages: Nucleus

8355:MGC64410
gene id: 8355:MGC64410
uniprot id: Q6PGS6
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:LOC108701900
gene id: 8355:LOC108701900
uniprot id: A0A8J1LT68
uniprot id: A0A8J1LUP1
uniprot id: A0A8J1LVK8
names: Caution
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: cilium membrane

8355:LOC121399769
gene id: 8355:LOC121399769
uniprot id: A0A8J1M899
names: Subcellular Location Annotation
messages: Membrane

8355:ldb1.S
gene id: 8355:ldb1.S
uniprot id: A0A8J0T543
uniprot id: A0A8J0TB71
uniprot id: A0A974CCA7
uniprot id: A9UM32
uniprot id: P70060
names: Developmental Stage
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the LDB family.
messages: Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. Acts as a coactivator together with otx2 to stimulate lhx1/lim1-mediated activation of the gsc promoter in the Spemann organizer. Acts synergistically with lhx1/lim1 and ssbp in axis formation.
messages: Expressed both maternally and zygotically during embryogenesis.
messages: Forms homodimers and heterodimers. Interacts with the LIM domain of LIM/homeobox factor lhx1/lim1, and with lhx3/lim3 and lhx5/lim5. Activates lhx1/lim1 by binding. The stoichiometry of lhx1/lim1 and ldb1 is important for their function and an excess of ldb1 can inhibit lhx1/lim1 function. When bound to lhx1/lim1, escapes degradation by rnf12. The N-terminus interacts with the N-terminal region of rnf12.
messages: Lacks LIM-binding domain.
messages: Nucleus
messages: The dimerization domain is located in the N-terminus.
messages: Ubiquitously expressed in the early gastrula before localizing to the dorsal region of the vegetal hemisphere, which contains the Spemann organizer. Expressed in the CNS, pronephros and tail bud in neurula and tail-bud stage embryos. Expressed in multiple adult tissues including brain, heart, lung, stomach, intestine, liver, spleen, kidney, ovary, muscle and skin.
messages: Undergoes rnf12-mediated ubiquitin-proteasome-dependent degradation.

8355:tgfa.L
gene id: 8355:tgfa.L
uniprot id: Q5PPZ2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:meltf.L
gene id: 8355:meltf.L
uniprot id: A0A8J0VH64
uniprot id: A0A8J1KPJ5
names: Similarity
messages: Belongs to the transferrin family.

8355:LOC108713213
gene id: 8355:LOC108713213
uniprot id: A0A1L8GUW3
uniprot id: A0A974D8T0
names: Subcellular Location Annotation
messages: Membrane

8355:LOC121395648
gene id: 8355:LOC121395648
uniprot id: A0A1L8FNY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

8355:MGC131348
gene id: 8355:MGC131348
uniprot id: A0A1L8EKY8
uniprot id: A0A8J1LWD2
uniprot id: A0A974BSD2
uniprot id: Q3KPS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8355:ddi2.L
gene id: 8355:ddi2.L
uniprot id: A0A1L8FP79
uniprot id: A0A8J1L8F7
uniprot id: A0A8J1L8G9
names: Similarity
messages: Belongs to the DDI1 family.

8355:fdps.L
gene id: 8355:fdps.L
uniprot id: A0A1L8FDJ2
uniprot id: A0A974CAP4
uniprot id: Q3KPW7
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

8355:tpm3.S
gene id: 8355:tpm3.S
uniprot id: A0A8J1LKG7
uniprot id: A0A8J1LKM4
uniprot id: A0A8J1LLE5
uniprot id: A0A8J1LLF2
uniprot id: A0A8J1LLQ1
uniprot id: A0A8J1LMY3
uniprot id: Q6PA57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

8355:ints12.S
gene id: 8355:ints12.S
uniprot id: A0A8J1LP85
uniprot id: A0A974I0D7
uniprot id: Q6DJM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 12 family.
messages: Belongs to the multiprotein complex Integrator.
messages: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.
messages: Nucleus

8355:LOC121401560
gene id: 8355:LOC121401560
uniprot id: A0A8J1MLX6
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:LOC108707425
gene id: 8355:LOC108707425
uniprot id: A0A1L8HCM2
uniprot id: A0A8J0UBG5
uniprot id: A0A8J1M857
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8355:aebp2.S
gene id: 8355:aebp2.S
uniprot id: Q6GR30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AEBP2/jing C2H2-type zinc-finger family.
messages: DNA-binding transcriptional repressor. May interact with and stimulate the activity of histone methyltransferase complexes.
messages: Nucleus

8355:LOC108711361
gene id: 8355:LOC108711361
uniprot id: A0A1L8H0D0
uniprot id: A0A974DCZ3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:pon2.S
gene id: 8355:pon2.S
uniprot id: Q6IRR7
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.
messages: Glycosylated.

8355:pdik1l.L
gene id: 8355:pdik1l.L
uniprot id: A0A8J0UEI5
uniprot id: A0A974DNZ3
uniprot id: Q6NU98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Nucleus

8355:hoxd1.S
gene id: 8355:hoxd1.S
uniprot id: A0A1L8EP93
uniprot id: Q08820
names: Developmental Stage
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Expression is abundant in the gastrula dorsal lip.
messages: First detected at stage 10.5 and peaks at mid-gastrula (stage 11.5).
messages: Nucleus
messages: Sequence of unknown origin at C-terminus.
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Acts downstream of meis3 to pattern the hindbrain.

8355:LOC121396891
gene id: 8355:LOC121396891
uniprot id: A0A8J1LGE9
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8355:gns.L
gene id: 8355:gns.L
uniprot id: A0A1L8GYG5
uniprot id: A0A8J0UQX5
uniprot id: A0A974HSI0
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Lysosome
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

8355:sgtb.L
gene id: 8355:sgtb.L
uniprot id: A0A8J0U4N7
uniprot id: A0A8J0UCX8
uniprot id: A0A974E276
uniprot id: Q6GM15
names: Similarity
messages: Belongs to the SGT family.

8355:cldn5.L
gene id: 8355:cldn5.L
uniprot id: Q6PA22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8355:rcl1.L
gene id: 8355:rcl1.L
uniprot id: A0A974E1V0
uniprot id: Q7ZXF0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: nucleolus

8355:c5orf24.S
gene id: 8355:c5orf24.S
uniprot id: A0A1L8GRC2
uniprot id: A0A974D817
names: Similarity
messages: Belongs to the UPF0461 family.

8355:ank1.S
gene id: 8355:ank1.S
uniprot id: A0A8J1MNK2
uniprot id: A0A8J1MNK8
uniprot id: A0A8J1MNQ0
uniprot id: A0A8J1MPK6
uniprot id: A0A8J1MPM6
uniprot id: A0A8J1MQP3
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

8355:rab3b.S
gene id: 8355:rab3b.S
uniprot id: A0A1L8GFW8
uniprot id: A0A974D219
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

8355:LOC121401585
gene id: 8355:LOC121401585
uniprot id: A0A1L8H242
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108705403
gene id: 8355:LOC108705403
uniprot id: A0A8J1L8W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

8355:smarcal1.L
gene id: 8355:smarcal1.L
uniprot id: A0A1L8EVE4
uniprot id: A0A974H3Q6
uniprot id: Q498E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA (By similarity).
messages: Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.
messages: Nucleus

8355:LOC108695642
gene id: 8355:LOC108695642
uniprot id: A0A8J0T957
names: Subcellular Location Annotation
messages: Membrane

8355:LOC121398088
gene id: 8355:LOC121398088
uniprot id: A0A1L8G0S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:LOC108710624
gene id: 8355:LOC108710624
uniprot id: A0A1L8H262
uniprot id: A0A974HU85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:sst.1.L
gene id: 8355:sst.1.L
uniprot id: Q7T1M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

8355:rspo1.L
gene id: 8355:rspo1.L
uniprot id: A0A1L8HFF7
uniprot id: A0A974DP69
names: Similarity
messages: Belongs to the R-spondin family.

8355:cpped1.L
gene id: 8355:cpped1.L
uniprot id: A9UMN7
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. CPPED1 family.

8355:snrpg.S
gene id: 8355:snrpg.S
uniprot id: A0A974HQE9
uniprot id: Q0IH31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

8355:acss2.1.L
gene id: 8355:acss2.1.L
uniprot id: A0A1L8EU13
uniprot id: A0A8J0TUU2
uniprot id: A0A8J0TW24
uniprot id: A0A974BXJ4
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

8355:alkbh1.L
gene id: 8355:alkbh1.L
uniprot id: Q640F9
names: Cofactor
messages: Binds 1 Fe(2+) ion per subunit.

8355:syngr1.L
gene id: 8355:syngr1.L
uniprot id: A0A8J0UYU3
uniprot id: A0A974D5I5
uniprot id: Q8UW67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

8355:fam83c.S
gene id: 8355:fam83c.S
uniprot id: A0A1L8EL04
uniprot id: A0A974H0G7
names: Similarity
messages: Belongs to the FAM83 family.

8355:mcidas.L
gene id: 8355:mcidas.L
uniprot id: A0A1L8I2H1
uniprot id: A0A8J0VE15
uniprot id: A0A974E2E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

8355:myod1.L
gene id: 8355:myod1.L
uniprot id: Q6GN48
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

8355:slc7a4.S
gene id: 8355:slc7a4.S
uniprot id: A0A1L8HQ50
uniprot id: A0A974I1R1
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108699343
gene id: 8355:LOC108699343
uniprot id: A0A8J0TLF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

8355:LOC121397983
gene id: 8355:LOC121397983
uniprot id: A0A1L8EYW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:ormdl1.S
gene id: 8355:ormdl1.S
uniprot id: A0A974BVB1
uniprot id: Q5XH57
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORM family.
messages: Ceramide-sensitive subunit of the serine palmitoyltransferase (SPT) complex, which is also composed of SPTLC1, SPTLC2/3 and SPTSSA/B.
messages: Ceramides bind to ORMDL3 N-terminus and stabilize it in a conformation that physically restricts the accessibility of the substrates to their binding sites in the serine palmitoyltransferase (SPT) complex, hence inhibiting SPT catalytic activity. In the absence of ceramides, the N-terminus is flexible and permits substrate binding, thus liberating SPT from inhibition.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.
messages: Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels (By similarity). When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (By similarity).

8355:ensa.L
gene id: 8355:ensa.L
uniprot id: A0A974C9C1
uniprot id: Q6P425
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with ppp2r2d (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase.

8355:rev3l.S
gene id: 8355:rev3l.S
uniprot id: A0A1L8G2X7
uniprot id: A0A8J1KTB8
uniprot id: A0A974CT32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

8355:LOC121393446
gene id: 8355:LOC121393446
uniprot id: A0A8J1KKU7
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108709305
gene id: 8355:LOC108709305
uniprot id: A0A1L8H5V4
uniprot id: A0A974DI85
names: Subcellular Location Annotation
messages: Membrane

8355:endou.L
gene id: 8355:endou.L
uniprot id: A0A1L8HIC8
uniprot id: A0A8J1M9Y0
uniprot id: A0A974DRI4
names: Similarity
names: Subunit
messages: Belongs to the ENDOU family.
messages: Monomer.

8355:tmtops2.L
gene id: 8355:tmtops2.L
uniprot id: A0A1L8HGU3
uniprot id: A0A974DQS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

8355:fbln7.L
gene id: 8355:fbln7.L
uniprot id: A0A1L8G722
uniprot id: A0A974CU05
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108710342
gene id: 8355:LOC108710342
uniprot id: A0A8J0UP75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:zfpm2.L
gene id: 8355:zfpm2.L
uniprot id: A0A1L8FZV8
uniprot id: A0A8J0VPG6
uniprot id: A0A974CPV4
names: Subcellular Location Annotation
messages: Nucleus

8355:rcc2.L
gene id: 8355:rcc2.L
uniprot id: Q52KW8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Chromosome
messages: Interacts with RAC1. Interacts with CORO1C.
messages: Midbody
messages: Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA. Required for normal progress through the cell cycle, both during interphase and during mitosis. Required for normal attachment of kinetochores to mitotic spindles. Required for normal organization of the microtubule cytoskeleton in interphase cells. Interferes with the activation of RAC1 by guanine nucleotide exchange factors. Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions. Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration.
messages: Nucleus
messages: centromere
messages: cytoskeleton
messages: nucleolus
messages: spindle

8355:LOC108695649
gene id: 8355:LOC108695649
uniprot id: A0A8J1MHN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8355:dhx32.L
gene id: 8355:dhx32.L
uniprot id: Q5XH12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Mitochondrion
messages: Nucleus

8355:ppp1r9al.L
gene id: 8355:ppp1r9al.L
uniprot id: A0A1L8EW81
uniprot id: A0A8J0TMN4
uniprot id: A0A8J0TV48
uniprot id: A0A974H3I5
names: Subcellular Location Annotation
messages: cytoskeleton

8355:tspan36.S
gene id: 8355:tspan36.S
uniprot id: A0A974I248
uniprot id: Q6GP11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8355:LOC108715693
gene id: 8355:LOC108715693
uniprot id: A0A1L8GGH3
uniprot id: A0A974CZU8
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

8355:ss18l1.L
gene id: 8355:ss18l1.L
uniprot id: A0A1L8ESY2
uniprot id: A0A974H2Y3
names: Similarity
messages: Belongs to the SS18 family.

8355:hsph1.S
gene id: 8355:hsph1.S
uniprot id: Q6DE28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm

8355:rnpc3.L
gene id: 8355:rnpc3.L
uniprot id: A0A1L8GN60
uniprot id: A0A974D525
names: Subcellular Location Annotation
messages: Nucleus

8355:s100a1.L
gene id: 8355:s100a1.L
uniprot id: A0A1L8FD72
uniprot id: A0A974H977
names: Similarity
messages: Belongs to the S-100 family.

8355:aasdh.L
gene id: 8355:aasdh.L
uniprot id: A0A1L8HTW3
uniprot id: A0A974DYC9
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

8355:hspb1.S
gene id: 8355:hspb1.S
uniprot id: Q66KZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: spindle

8355:phf5a.L
gene id: 8355:phf5a.L
uniprot id: A0A8J1MXP4
uniprot id: Q5I000
names: Similarity
messages: Belongs to the PHF5 family.

8355:cmtm8.S
gene id: 8355:cmtm8.S
uniprot id: A0A1L8FRH0
uniprot id: A0A974CK89
names: Subcellular Location Annotation
messages: Membrane

8355:ncs1.L
gene id: 8355:ncs1.L
uniprot id: Q91614
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the recoverin family.
messages: Binds 3 calcium ions via the second, third and fourth EF-hand.
messages: Brain.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus
messages: Is not detectable until stage 21, when spinal neurons begin to establish synaptic contacts with muscle cells, levels increase dramatically around stage 40.
messages: Membrane
messages: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity).
messages: Postsynaptic density
messages: perinuclear region

8355:gnb1.S
gene id: 8355:gnb1.S
uniprot id: A0A974CCG4
uniprot id: Q5XH13
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

8355:LOC108704068
gene id: 8355:LOC108704068
uniprot id: A0A8J0TW04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

8355:rcan3.L
gene id: 8355:rcan3.L
uniprot id: A0A1L8HFQ8
uniprot id: A0A974DMX8
names: Similarity
messages: Belongs to the RCAN family.

8355:slc10a7.S
gene id: 8355:slc10a7.S
uniprot id: A0A8J0TQ60
uniprot id: A0A974DS26
uniprot id: Q7T0V6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Cell membrane
messages: Does not show transport activity towards bile acids or steroid sulfates.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization. Also involved in the regulation of cellular calcium homeostasis. Does not show transport activity towards bile acids or steroid sulfates.
messages: Strongly expressed in small intestine. Moderately expressed in spleen. Weakly expressed in skeletal muscle. Not detected in other tissues tested.

8355:prdx6.L
gene id: 8355:prdx6.L
uniprot id: A0A974D6Q4
uniprot id: Q7SYT1
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

8355:LOC121395570
gene id: 8355:LOC121395570
uniprot id: A0A1L8FMA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8355:LOC108697740
gene id: 8355:LOC108697740
uniprot id: A0A1L8HT29
uniprot id: A0A8J0T765
uniprot id: A0A974I2J0
names: Similarity
messages: Belongs to the lst-2 family.

8355:bbs5.L
gene id: 8355:bbs5.L
uniprot id: A0A1L8EW62
uniprot id: A0A974BZ58
uniprot id: A0A974BZ74
uniprot id: Q66IS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBS5 family.
messages: Membrane
messages: Required for ciliogenesis.
messages: centriolar satellite
messages: cilium membrane

8355:cldn17.1.S
gene id: 8355:cldn17.1.S
uniprot id: A0A1L8H576
uniprot id: A0A974HUZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8355:lpar5.S
gene id: 8355:lpar5.S
uniprot id: A0A1L8FDZ3
uniprot id: A0A8J0T5I5
uniprot id: A0A974CAV7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:rbp4l.L
gene id: 8355:rbp4l.L
uniprot id: A0A974DZG9
uniprot id: Q642Q9
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

8355:clrn3.L
gene id: 8355:clrn3.L
uniprot id: A0A1L8FJ48
uniprot id: A0A974CF66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

8355:LOC108704939
gene id: 8355:LOC108704939
uniprot id: A0A8J1M499
uniprot id: A0A8J1M4Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

8355:slc4a3.L
gene id: 8355:slc4a3.L
uniprot id: A0A1L8EVH4
uniprot id: A0A974H3R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Membrane

8355:tmprss6.L
gene id: 8355:tmprss6.L
uniprot id: A0A1L8GP16
uniprot id: A0A8J1MXS5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:miox.S
gene id: 8355:miox.S
uniprot id: A0A974HR20
uniprot id: Q641D2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myo-inositol oxygenase family.
messages: Binds 2 iron ions per subunit.
messages: Cytoplasm

8355:arpc5.L
gene id: 8355:arpc5.L
uniprot id: Q68FI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC5 family.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of actr2/arp2, actr3/arp3, arpc1 (arpc1a or arpc1b), arpc2, arpc3, arpc4 and arpc5.
messages: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:17178911). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:17178911). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).
messages: Nucleus
messages: cytoskeleton

8355:atad3a.S
gene id: 8355:atad3a.S
uniprot id: Q58E76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important role in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis (By similarity).
messages: Mitochondrion inner membrane
messages: mitochondrion nucleoid

8355:grm3.S
gene id: 8355:grm3.S
uniprot id: A0A1L8GTT9
uniprot id: A0A974D7W5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
messages: Interacts with TAMALIN.
messages: Membrane

8355:LOC108702816
gene id: 8355:LOC108702816
uniprot id: A0A8J0TZW3
names: Subcellular Location Annotation
messages: Membrane

8355:fam174c.L
gene id: 8355:fam174c.L
uniprot id: A0A1L8HX54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

8355:plod3.L
gene id: 8355:plod3.L
uniprot id: Q7ZY90
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

8355:adgrb2.S
gene id: 8355:adgrb2.S
uniprot id: A0A8J0UCM7
uniprot id: A0A8J1ME11
uniprot id: A0A8J1MEY9
uniprot id: A0A8J1MFV5
names: Subcellular Location Annotation
messages: Membrane

8355:pxn.L
gene id: 8355:pxn.L
uniprot id: A0A1L8I058
uniprot id: A0A8J0V8A4
uniprot id: A0A974E2K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paxillin family.
messages: cell cortex
messages: cytoskeleton
messages: focal adhesion

8355:trappc2.S
gene id: 8355:trappc2.S
uniprot id: A0A974DJV2
uniprot id: Q641A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

8355:erh.S
gene id: 8355:erh.S
uniprot id: Q71U69
names: Function
names: Similarity
messages: Belongs to the E(R) family.
messages: May have a role in the cell cycle.

8355:LOC108702189
gene id: 8355:LOC108702189
uniprot id: A0A8J1LZ91
uniprot id: A0A8J1LZB4
uniprot id: A0A8J1LZG2
uniprot id: A0A8J1M0I4
uniprot id: A0A8J1M1F2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

8355:tp53bp1.L
gene id: 8355:tp53bp1.L
uniprot id: A0A1L8H0P7
uniprot id: A0A8J1MNX7
uniprot id: A0A974HTG0
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108698765
gene id: 8355:LOC108698765
uniprot id: A0A1L8F9V1
uniprot id: A0A974C860
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

8355:baat.S
gene id: 8355:baat.S
uniprot id: A0A1L8HRY1
uniprot id: A0A8J1M4D4
uniprot id: A0A8J1M5H1
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

8355:c6orf120.S
gene id: 8355:c6orf120.S
uniprot id: A0A8J0VEY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0669 family.
messages: Secreted

8355:LOC108696127
gene id: 8355:LOC108696127
uniprot id: A0A1L8FJ58
uniprot id: A0A8J0T0N4
uniprot id: A0A8J1L4V8
uniprot id: A0A974CEI8
names: Similarity
messages: Belongs to the RRM CPEB family.

8355:slc25a39.L
gene id: 8355:slc25a39.L
uniprot id: A0A8J1LPT1
uniprot id: A0A8J1LR26
uniprot id: Q6GP92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8355:ncaph.L
gene id: 8355:ncaph.L
uniprot id: Q7T0P8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND2 (condensin subunit 2) family.
messages: Chromosome
messages: Cytoplasm
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.

8355:pex1.L
gene id: 8355:pex1.L
uniprot id: A0A8J0VEN8
uniprot id: Q6GQJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: cytosol

8355:LOC495046
gene id: 8355:LOC495046
uniprot id: A0A8J1M864
uniprot id: A0A974I5S7
uniprot id: Q4KLX4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

8355:LOC108717228
gene id: 8355:LOC108717228
uniprot id: A0A1L8GC81
uniprot id: A0A974HKG0
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:tnfrsf21.L
gene id: 8355:tnfrsf21.L
uniprot id: A0A1L8GC21
uniprot id: A0A974CYW1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:rtf2.S
gene id: 8355:rtf2.S
uniprot id: A0A1L8ELJ9
uniprot id: A0A974BSY1
uniprot id: Q7SYZ1
names: Similarity
messages: Belongs to the rtf2 family.

8355:slc27a2.L
gene id: 8355:slc27a2.L
uniprot id: A0A1L8H0L7
uniprot id: A0A974DES8
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

8355:ncor1.S
gene id: 8355:ncor1.S
uniprot id: A0A8J1MB69
uniprot id: A0A8J1MB71
uniprot id: A0A8J1MB75
uniprot id: A0A8J1MB78
uniprot id: A0A8J1MBI2
uniprot id: A0A8J1MBI8
uniprot id: A0A8J1MC63
uniprot id: A0A8J1MC69
uniprot id: A0A8J1MCY7
uniprot id: A0A8J1MCZ5
uniprot id: Q8QG78
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the N-CoR nuclear receptor corepressors family.
messages: By thyroid hormone in the developing intestine and tail.
messages: Expressed in the developing intestine both prior to and during remodeling (stages NF54 to NF66). Also expressed at high levels in the tail during tail regression (stages NF62 and NF64) and in the hindlimbs during hindlimb morphogenesis (stage NF56).
messages: Forms a large corepressor complex that contains sin3a/b, histone deacetylases hdac1 and hdac2, rbbp4 and possibly rbbp7. Interacts with the thyroid receptor (TR, composed of rxra and thrb) and the retinoid acid receptor (RAR, composed of rxra and rara) in the absence of ligand. Interacts with tbl1xr1-A and possibly tbl1xr1-B. Interacts with zbtb33/kaiso.
messages: Mediates transcriptional repression by certain nuclear receptors. Participates in complexes which promote histone deacetylation and the formation of repressive chromatin structures which may impede access by the basal transcription machinery. In association with hdac3, may play a role in the regulation of the circadian clock (By similarity).
messages: Nucleus
messages: The CORNR box motifs in the C-terminal region may be necessary and sufficient for binding to unligated nuclear hormone receptors. Sequences flanking these motifs may determine the precise nuclear hormone receptor specificity (By similarity).

8355:slc6a1.S
gene id: 8355:slc6a1.S
uniprot id: A0A1L8GQV9
uniprot id: A0A974HQH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8355:cpa1.S
gene id: 8355:cpa1.S
uniprot id: A0A8J0UXG9
uniprot id: A0A974D9G7
uniprot id: Q6PGR7
names: Similarity
messages: Belongs to the peptidase M14 family.

8355:osbpl2.S
gene id: 8355:osbpl2.S
uniprot id: A0A974BTA4
uniprot id: Q6GNX2
names: Similarity
messages: Belongs to the OSBP family.

8355:gabrb3.S
gene id: 8355:gabrb3.S
uniprot id: A0A1L8H8U2
uniprot id: A0A974DJD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8355:tuba1c.S
gene id: 8355:tuba1c.S
uniprot id: A0A974DKF6
uniprot id: Q7ZWQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

8355:areg.S
gene id: 8355:areg.S
uniprot id: A0A1L8HMF4
uniprot id: A0A8J0U7P2
uniprot id: A0A974DSH6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC121398844
gene id: 8355:LOC121398844
uniprot id: A0A8J1LXJ1
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:ergic1.S
gene id: 8355:ergic1.S
uniprot id: A0A974D9G1
uniprot id: Q6NS19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.
messages: Possible role in transport between endoplasmic reticulum and Golgi.

8355:LOC108695654
gene id: 8355:LOC108695654
uniprot id: A0A8J0T9D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108713110
gene id: 8355:LOC108713110
uniprot id: A0A8J1MRN3
uniprot id: A0A8J1MSP5
uniprot id: A0A8J1MTX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

8355:LOC108696894
gene id: 8355:LOC108696894
uniprot id: A0A1L8HYB5
uniprot id: A0A974I4F5
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:urad.L
gene id: 8355:urad.L
uniprot id: A0A974DQ50
uniprot id: A1L1C5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OHCU decarboxylase family.
messages: Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.
messages: Peroxisome

8355:LOC108714721
gene id: 8355:LOC108714721
uniprot id: A0A1L8GQ74
uniprot id: A0A974HQ83
names: Subcellular Location Annotation
messages: cytoskeleton

8355:erf.S
gene id: 8355:erf.S
uniprot id: A0A8J0TDW9
uniprot id: Q3B8H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8355:ctsc.L
gene id: 8355:ctsc.L
uniprot id: A0A974I017
uniprot id: Q7T0N7
names: Similarity
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.

8355:LOC108706793
gene id: 8355:LOC108706793
uniprot id: A0A974DYM5
uniprot id: Q6DKD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

8355:xnf7.L
gene id: 8355:xnf7.L
uniprot id: Q92021
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: At the neurula stage, high expression in dorsal embryo region including neural folds and somites. Also high expression in adult brain (CNS) and low expression in oocytes.
messages: Expressed both maternally and zygotically.
messages: Monomer.
messages: Nucleus
messages: Threonine (predominantly) and serine residues are phosphorylated during oocyte maturation, when CDK1 is active.
messages: Transcription factor that determines dorsal-ventral body axis.

8355:dnajc25.S
gene id: 8355:dnajc25.S
uniprot id: A0A8J0Q260
names: Similarity
messages: Belongs to the DNAJC25 family.

8355:tfdp2.L
gene id: 8355:tfdp2.L
uniprot id: A0A8J1KQ24
uniprot id: A0A8J1KT74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

8355:LOC108699265
gene id: 8355:LOC108699265
uniprot id: H6D7E8
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:gsto1.S
gene id: 8355:gsto1.S
uniprot id: A0A8J0TDU2
uniprot id: Q5U546
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

8355:cd3e.L
gene id: 8355:cd3e.L
uniprot id: A0A1L8FLK6
uniprot id: A0A974HC38
names: Subcellular Location Annotation
messages: Membrane

8355:gja5.S
gene id: 8355:gja5.S
uniprot id: A0A1L8H5G0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8355:mmp17.S
gene id: 8355:mmp17.S
uniprot id: A0A1L8HQI6
uniprot id: A0A8J1M3I1
uniprot id: A0A8J1M3I3
uniprot id: A0A974I235
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

8355:spire1.S
gene id: 8355:spire1.S
uniprot id: A0A8J1LYB1
uniprot id: A0A974BT98
uniprot id: Q6DFF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spire family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytoskeleton

8355:lmnb3.S
gene id: 8355:lmnb3.S
uniprot id: A0A1L8GSQ9
uniprot id: A0A8J0UN32
uniprot id: A0A8J0UV05
uniprot id: A0A974DA03
uniprot id: Q32NH4
names: Similarity
messages: Belongs to the intermediate filament family.

8355:arf1.S
gene id: 8355:arf1.S
uniprot id: A0A974BS88
uniprot id: Q8AVF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

8355:LOC121398349
gene id: 8355:LOC121398349
uniprot id: A0A1L8HM60
names: Similarity
messages: Belongs to the DDIT4 family.

8355:LOC108720089
gene id: 8355:LOC108720089
uniprot id: A0A1L8FSE2
uniprot id: A0A974CKU7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC121398925
gene id: 8355:LOC121398925
uniprot id: A0A8J1LY68
names: Similarity
messages: Belongs to the cyclin family.

8355:LOC108697603
gene id: 8355:LOC108697603
uniprot id: A0A1L8FFY4
uniprot id: A0A974CDD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8355:mrpl22.L
gene id: 8355:mrpl22.L
uniprot id: A0A8J1MJS6
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

8355:mxra8.L
gene id: 8355:mxra8.L
uniprot id: A0A1L8FM42
uniprot id: A0A974CH68
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:nol10.L
gene id: 8355:nol10.L
uniprot id: A0A974HKB2
uniprot id: Q7T0Q5
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: Contaminating sequence. Potential poly-A sequence.
messages: nucleolus

8355:mmp3.L
gene id: 8355:mmp3.L
uniprot id: Q6DCN8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

8355:LOC121393448
gene id: 8355:LOC121393448
uniprot id: A0A8J1KMI9
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108712399
gene id: 8355:LOC108712399
uniprot id: A0A1L8GV44
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8355:LOC108707586
gene id: 8355:LOC108707586
uniprot id: A0A8J1MBD0
uniprot id: A0A8J1MC51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

8355:arpc5.S
gene id: 8355:arpc5.S
uniprot id: Q641B9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC5 family.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of actr2/arp2, actr3/arp3, arpc1 (arpc1a or arpc1b), arpc2, arpc3, arpc4 and arpc5.
messages: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).
messages: Nucleus
messages: cytoskeleton

8355:atrn.S
gene id: 8355:atrn.S
uniprot id: A0A1L8HKI6
uniprot id: A0A8J1M2N2
uniprot id: A0A974I0D0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108715283
gene id: 8355:LOC108715283
uniprot id: A0A1L8GDY6
uniprot id: A0A8J0V502
uniprot id: A0A8J1KHV0
uniprot id: A0A8J1KHW1
uniprot id: A0A8J1KL08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mical family.
messages: Cytoplasm

8355:exo1.S
gene id: 8355:exo1.S
uniprot id: Q9W6K2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR) (By similarity).
messages: Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Nucleus

8355:dsg2.S
gene id: 8355:dsg2.S
uniprot id: A0A1L8FSX6
uniprot id: A0A974CK29
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: desmosome

8355:pax3.L
gene id: 8355:pax3.L
uniprot id: A0A1L8GAL5
uniprot id: A0A8J0V5H5
uniprot id: A0A8J0V8P6
uniprot id: A0A8J0V9C8
uniprot id: A0A974CW34
uniprot id: A0A974CX03
uniprot id: Q0IH87
names: Function
names: Induction
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the paired homeobox family.
messages: By wnt-signaling from the posterior mesoderm.
messages: Expressed in the dorsolateral ectoderm during early and mid-gastrula stages. At late-gastrula and neurula stages, expressed in the lateral neural plate, becoming progressively refined to the neural folds during convergence and extension. Expression is also restricted in the A/P axis, extending into the midbrain but excluded from the forebrain.
messages: May contain intron retention.
messages: Nucleus
messages: Probable transcription factor. Promotes both hatching gland and neural crest cell fates, two of the cell populations that arise from the neural plate border. Acts downstream of msx1 to induce the neural crest, cooperating with zic1 and mediating signals from both the wnt and fgf8 signaling pathways. Induction of hatching gland cell fate is independent of zic1.

8355:LOC121394353
gene id: 8355:LOC121394353
uniprot id: A0A8J1KWG7
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:ube2v1.L
gene id: 8355:ube2v1.L
uniprot id: A0A8J1LPJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase CarF family.
messages: Membrane

8355:LOC108707475
gene id: 8355:LOC108707475
uniprot id: A0A8J1M825
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

8355:frg1.L
gene id: 8355:frg1.L
uniprot id: A0A1L8HU14
uniprot id: A0A8J0UFN6
uniprot id: A0A974DXZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRG1 family.
messages: Cajal body
messages: nucleolus

8355:LOC108711035
gene id: 8355:LOC108711035
uniprot id: A0A8J0UQR0
uniprot id: A0A8J0UTX3
names: Similarity
messages: Belongs to the OCC1 family.

8355:maml2.L
gene id: 8355:maml2.L
uniprot id: A0A1L8HJB6
uniprot id: A0A974HZZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mastermind family.
messages: Nucleus speckle

8355:LOC121394573
gene id: 8355:LOC121394573
uniprot id: A0A8J1KYW0
names: Subcellular Location Annotation
messages: Membrane

8355:ccr2.L
gene id: 8355:ccr2.L
uniprot id: A0A974CPH2
uniprot id: Q640C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8355:jph4.L
gene id: 8355:jph4.L
uniprot id: A0A1L8HYU1
uniprot id: A0A974I4B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:gab1.L
gene id: 8355:gab1.L
uniprot id: A0A310TNH6
uniprot id: A0A8J0U7G1
uniprot id: A0A8J1MA57
uniprot id: A0A8J1MA62
uniprot id: A0A974GZC5
uniprot id: Q6DDF9
names: Similarity
messages: Belongs to the GAB family.

8355:akr1a1.L
gene id: 8355:akr1a1.L
uniprot id: A0A1L8GM75
uniprot id: A0A8J0UZ56
uniprot id: A0A8J0V334
uniprot id: Q6GMC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the aldo/keto reductase family.
messages: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids. Acts as an aldehyde-detoxification enzyme (By similarity). Displays no reductase activity towards retinoids (By similarity).
messages: Cell membrane
messages: Membrane
messages: cytosol

8355:nubp1.L
gene id: 8355:nubp1.L
uniprot id: A0A974C031
uniprot id: Q3KQF0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of nubp1 and two labile, bridging clusters between subunits of the nubp1-nubp2 heterotetramer.
messages: Cell projection
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The nubp1-nubp2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains.
messages: Heterotetramer of 2 nubp1 and 2 nubp2 chains.

8355:ppp2r2d.S
gene id: 8355:ppp2r2d.S
uniprot id: A0A974H9M5
uniprot id: Q7ZX64
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing ppp2r2d (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ensa and arpp19 inhibitors. PP2A complexes containing ppp2r2d (PR55-delta) also regulate the activity of TGF-beta/Activin/Nodal signaling by restricting receptor activity. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and may also direct the localization of the catalytic enzyme to a particular subcellular compartment.
messages: Belongs to the phosphatase 2A regulatory subunit B family.
messages: Cytoplasm
messages: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with ensa (when phosphorylated at 'Ser-67') and arpp19 (when phosphorylated at 'Ser-67'), leading to inhibit PP2A activity.
messages: ppp2r2d is an abundant subunit in egg extracts and represents 70% or more of B55 subunits.

8355:LOC108699061
gene id: 8355:LOC108699061
uniprot id: A0A8J0TMF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108695335
gene id: 8355:LOC108695335
uniprot id: A0A1L8FT90
uniprot id: A0A974HEB9
names: Similarity
messages: Belongs to the glutaredoxin family.

8355:psmd8.L
gene id: 8355:psmd8.L
uniprot id: A2RV94
names: Similarity
messages: Belongs to the proteasome subunit S14 family.

8355:LOC121397323
gene id: 8355:LOC121397323
uniprot id: A0A1L8FBJ9
names: Subcellular Location Annotation
messages: Membrane

8355:btbd10.L
gene id: 8355:btbd10.L
uniprot id: A0A8J0UYP0
uniprot id: A0A8J1MTC2
uniprot id: A0A974D3H7
uniprot id: Q08B60
names: Subcellular Location Annotation
messages: Cytoplasm

8355:cep41.L
gene id: 8355:cep41.L
uniprot id: A0JPH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP41 family.
messages: Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of tubulin polyglutamylases between the basal body and the cilium (By similarity).
messages: centrosome
messages: cilium
messages: cilium basal body

8355:agbl1.L
gene id: 8355:agbl1.L
uniprot id: A0A1L8H0X5
uniprot id: A0A974DCU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

8355:eef1akmt2.S
gene id: 8355:eef1akmt2.S
uniprot id: A0A1L8FEB3
uniprot id: A0A974CBA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
messages: Cytoplasm
messages: Nucleus
messages: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'.

8355:KEF37 p11
gene id: 8355:KEF37_p11
uniprot id: P00398
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 2 heme A groups non-covalently per subunit.
messages: Binds a copper B center.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). As a newly synthesized protein, rapidly incorporates into a multi-subunit assembly intermediate in the inner membrane, called MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase) complex, whose core components are COA3/MITRAC12 and COX14. Within the MITRAC complex, interacts with COA3 and with SMIM20/MITRAC7; the interaction with SMIM20 stabilizes the newly synthesized MT-CO1 and prevents its premature turnover. Interacts with TMEM177 in a COX20-dependent manner (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

8355:LOC108718728
gene id: 8355:LOC108718728
uniprot id: A0A8J0VFS9
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:XB987369.L
gene id: 8355:XB987369.L
uniprot id: A0A1L8FK09
uniprot id: A0A8J1L5F6
uniprot id: A0A974HBJ2
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
messages: Secreted

8355:reep3.L
gene id: 8355:reep3.L
uniprot id: A0A974CE34
uniprot id: Q6P418
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes (By similarity).

8355:mettl15.S
gene id: 8355:mettl15.S
uniprot id: A0A1L8GD71
uniprot id: A0A974CXL2
uniprot id: Q6GQZ0
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmH family.

8355:LOC108698349
gene id: 8355:LOC108698349
uniprot id: A0A8J0TGL9
names: Similarity
messages: Belongs to the SUA5 family.

8355:polr2k.S
gene id: 8355:polr2k.S
uniprot id: A0A974CP42
uniprot id: Q6GQI6
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

8355:LOC108696658
gene id: 8355:LOC108696658
uniprot id: A0A1L8HWR2
uniprot id: A0A974I3Z3
names: Subcellular Location Annotation
messages: Membrane

8355:dse.S
gene id: 8355:dse.S
uniprot id: A0A166W5V8
uniprot id: A0A8J0VKV4
uniprot id: A0A974HHI3
names: Similarity
messages: Belongs to the dermatan-sulfate isomerase family.

8355:LOC108695274
gene id: 8355:LOC108695274
uniprot id: A0A8J0T7R3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: desmosome

8355:dusp8.L
gene id: 8355:dusp8.L
uniprot id: A0A1L8FNQ1
uniprot id: A0A974CH70
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

8355:zdhhc7.L
gene id: 8355:zdhhc7.L
uniprot id: A0A1L8GL03
uniprot id: A0A974D589
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:pdpk1.L
gene id: 8355:pdpk1.L
uniprot id: A0A8J0PX21
uniprot id: A0A8J0TT69
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.

8355:LOC108703056
gene id: 8355:LOC108703056
uniprot id: A0A1L8EPY6
uniprot id: A0A8J1M000
uniprot id: A0A974BUP3
names: Subcellular Location Annotation
messages: Membrane

8355:rps12.L
gene id: 8355:rps12.L
uniprot id: Q7ZY09
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

8355:LOC108697300
gene id: 8355:LOC108697300
uniprot id: A0A1L8FDM1
uniprot id: A0A974H9C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:iars2.L
gene id: 8355:iars2.L
uniprot id: A0A1L8G6E9
uniprot id: A0A974CTJ7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

8355:LOC108714977
gene id: 8355:LOC108714977
uniprot id: A0A8J1KIP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
messages: Peroxisome

8355:rassf1.S
gene id: 8355:rassf1.S
uniprot id: A0A1L8GHE8
names: Subcellular Location Annotation
messages: cytoskeleton

8355:atg5.L
gene id: 8355:atg5.L
uniprot id: Q6GR40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
messages: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
messages: Preautophagosomal structure membrane

8355:LOC121396919
gene id: 8355:LOC121396919
uniprot id: A0A8J1LIK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108701849
gene id: 8355:LOC108701849
uniprot id: A0A8J0TWU0
names: Similarity
messages: Belongs to the dynein heavy chain family.

8355:mrps12.L
gene id: 8355:mrps12.L
uniprot id: A0A974H7V3
uniprot id: Q7SZ18
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

8355:LOC121393601
gene id: 8355:LOC121393601
uniprot id: A0A8J1KMD2
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:mpg.L
gene id: 8355:mpg.L
uniprot id: A0A1L8EXC7
uniprot id: A0A8J1LUI8
uniprot id: A0A8J1LVY2
uniprot id: A0A974H4C3
names: Function
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.
messages: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.

8355:irak4.L
gene id: 8355:irak4.L
uniprot id: A0A1L8GYU8
uniprot id: A0A974DDZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Cytoplasm
messages: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.

8355:septin2.S
gene id: 8355:septin2.S
uniprot id: A0A1L8G4K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Midbody
messages: cilium membrane
messages: spindle

8355:ift20.S
gene id: 8355:ift20.S
uniprot id: A0A1L8H621
uniprot id: A0A974DHI6
uniprot id: Q640Z7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Golgi apparatus
messages: Involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella.
messages: centriole
messages: cilium
messages: cis-Golgi network

8355:LOC108701091
gene id: 8355:LOC108701091
uniprot id: A0A1L8EU78
uniprot id: A0A974BXL5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

8355:pdgfra.L
gene id: 8355:pdgfra.L
uniprot id: A0A1L8HTV1
uniprot id: A0A974DWL5
uniprot id: Q7ZY71
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.
messages: Membrane
messages: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.

8355:vipr2.S
gene id: 8355:vipr2.S
uniprot id: A0A8J1L2T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

8355:tbcel.L
gene id: 8355:tbcel.L
uniprot id: A0A8J0T6G8
uniprot id: A0A974CGX4
uniprot id: Q3B8H5
names: Subcellular Location Annotation
messages: Cytoplasm

8355:zc3hc1.S
gene id: 8355:zc3hc1.S
uniprot id: A0A1L8GTM4
uniprot id: A0A8J0UQS1
uniprot id: A0A974HR31
names: Subcellular Location Annotation
messages: Nucleus

8355:myadm.L
gene id: 8355:myadm.L
uniprot id: A0A974CH47
uniprot id: Q63ZU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL family.
messages: Membrane

8355:myo5a.S
gene id: 8355:myo5a.S
uniprot id: A0A1L8GSX4
uniprot id: A0A8J1MR02
uniprot id: A0A8J1MR51
uniprot id: A0A8J1MSA2
uniprot id: A0A974D852
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8355:itga5.S
gene id: 8355:itga5.S
uniprot id: A0A1L8HAA6
uniprot id: A0A8J1MH45
uniprot id: A0A974HWY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

8355:LOC108701818
gene id: 8355:LOC108701818
uniprot id: A0A8J1LUJ9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8355:adam33.L
gene id: 8355:adam33.L
uniprot id: O12960
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC121400625
gene id: 8355:LOC121400625
uniprot id: A0A8J1MEK3
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

8355:nbr1.L
gene id: 8355:nbr1.L
uniprot id: A0A8J0TSK2
uniprot id: A0A8J0TTL9
uniprot id: Q6PF38
names: Subcellular Location Annotation
messages: autophagosome

8355:LOC121401172
gene id: 8355:LOC121401172
uniprot id: A0A8J1MJ80
names: Similarity
messages: Belongs to the HARBI1 family.

8355:astl2b.L
gene id: 8355:astl2b.L
uniprot id: A5PKN4
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:mga.L
gene id: 8355:mga.L
uniprot id: A0A1L8FAD9
uniprot id: A0A8J0TMK4
uniprot id: A0A974C8J5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8355:mybl1.S
gene id: 8355:mybl1.S
uniprot id: A0A1L8FT65
uniprot id: A0A8J0T4T2
uniprot id: A0A8J0T721
uniprot id: A0A974CM68
names: Subcellular Location Annotation
messages: Nucleus

8355:tshz1.S
gene id: 8355:tshz1.S
uniprot id: A0A1L8FSM1
uniprot id: A0A974HE31
uniprot id: Q2HNT2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.
messages: Expressed in early blastula stage embryos with a decrease during gastrulation. Expressed at early neurula stage in two broad wedge-shaped domains within the neuroectoderm flanking the midline. Throughout neurula stages, the anterior limit of its expression is maintained at a position posterior to hindbrain rhombomere 5. Confined to the trunk region of the prospective CNS. At stage 26, expressed in a gradient spanning the presumptive hindbrain/spinal cord boundary, the diencephalon, the pronephros and the presumptive olfactory placodes. From late neurula stage on, its expression becomes detectable in a distinct population of emigrating cranial neural crest (CNC) cells of the third branchial arch. At stage 26, expressed in the entire hyoid and branchial arch region and strongly reduced in this domain at tailbud stage.
messages: Nucleus
messages: Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Involved in two major neuronal regionalization processes: primary anteroposterior (AP) axis patterning of the CNS and segmentation of the cranial neuronal crest (CNS) development.

8355:LOC108709749
gene id: 8355:LOC108709749
uniprot id: A0A1L8H912
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:nme4.S
gene id: 8355:nme4.S
uniprot id: A0A8J0TY28
uniprot id: Q5PQ84
names: Similarity
messages: Belongs to the NDK family.

8355:phf10.S
gene id: 8355:phf10.S
uniprot id: A0A1L8G2B3
uniprot id: A0A8J0VAL6
uniprot id: A0A8J0VDH5
uniprot id: A0A8J0VDV4
uniprot id: A0A974HH67
uniprot id: Q63ZP1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SAYP family.
messages: Component of neural progenitors-specific chromatin remodeling complex (npBAF complex), a subfamily of ATP-dependent SWI/SNF chromatin remodeling complexes.
messages: Involved in transcription activity regulation by chromatin remodeling in the context of the neural progenitors-specific chromatin remodeling complex (npBAF complex). May play a role in the proliferation of neural progenitors (By similarity).
messages: It is uncertain whether Met-1 or Met-90 is the initiator.
messages: Nucleus

8355:kalrn.S
gene id: 8355:kalrn.S
uniprot id: A0A8J1LX88
uniprot id: A0A8J1LX91
uniprot id: A0A8J1LX95
uniprot id: A0A8J1LXL0
uniprot id: A0A8J1LXL5
uniprot id: A0A8J1LYK2
uniprot id: A0A8J1LZG4
uniprot id: A0A8J1LZH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cell membrane
messages: Cytoplasm

8355:hpf1.L
gene id: 8355:hpf1.L
uniprot id: A0A1L8HU84
uniprot id: A0A974I2V3
names: Similarity
messages: Belongs to the HPF1 family.

8355:LOC108699046
gene id: 8355:LOC108699046
uniprot id: A0A8J1LK38
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:mepce.S
gene id: 8355:mepce.S
uniprot id: A0A8J0U3G1
names: Similarity
messages: Belongs to the methyltransferase superfamily.

8355:LOC108701542
gene id: 8355:LOC108701542
uniprot id: A0A0D3QS97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pectinacetylesterase family. Notum subfamily.
messages: Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors.
messages: Secreted

8355:ywhae.S
gene id: 8355:ywhae.S
uniprot id: A0A8J1MB40
uniprot id: A0A974DID3
uniprot id: O57468
names: Function
names: Similarity
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
messages: Belongs to the 14-3-3 family.

8355:rpl38.L
gene id: 8355:rpl38.L
uniprot id: A0A974BT94
uniprot id: Q66KV2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

8355:cdv3.S
gene id: 8355:cdv3.S
uniprot id: Q7ZYA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDV3 family.
messages: Cytoplasm

8355:LOC108710406
gene id: 8355:LOC108710406
uniprot id: A0A8J1MJL7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:plpp5.L
gene id: 8355:plpp5.L
uniprot id: A0A974DE81
uniprot id: Q6GQ62
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Cell membrane
messages: Magnesium-independent phospholipid phosphatase with broad substrate specificity. Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate. Phospholipid phosphatases are involved in both the synthesis of lipids and the generation or degradation of lipid-signaling molecules.
messages: Magnesium-independent phospholipid phosphatase. Inhibited by N-ethylmaleimide.
messages: Membrane

8355:mdk.L
gene id: 8355:mdk.L
uniprot id: A0A8J0USW6
uniprot id: A0A974D2D4
uniprot id: P48531
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the pleiotrophin family.
messages: In adults, expression is highest in the brain, eye and bone, with lower expression in the heart and lung. Not expressed in the ovary. In the tailbud stage embryo, expressed in the head and tail regions as well as in the central nervous system (CNS).
messages: Secreted
messages: Secreted protein that functions as cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptors via their chondroitin sulfate (CS) groups. Thereby regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration (By similarity). Inhibits mesoderm formation and promotes neural formation during development. Plays a role in development of the neuromuscular junction (NMJ). Has antibacterial activity against both Gram-positive and Gram-negative bacteria (By similarity).

8355:LOC108700477
gene id: 8355:LOC108700477
uniprot id: Q66KU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8355:tmem33.S
gene id: 8355:tmem33.S
uniprot id: A0A1L8HL24
uniprot id: A0A8J0UAM9
uniprot id: A0A974DRT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

8355:rars1.S
gene id: 8355:rars1.S
uniprot id: A0A1L8GVE9
uniprot id: A0A974D946
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

8355:LOC108700451
gene id: 8355:LOC108700451
uniprot id: A0A8J1LN08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

8355:incenp.S
gene id: 8355:incenp.S
uniprot id: A0A8J0V8S4
uniprot id: Q32N93
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the INCENP family.
messages: Chromosome
messages: Component of the CPC at least composed of survivin/birc5, incenp, cdca8/borealin and/or cdca9/dasra-A, and aurkb/aurora-B. Interacts (via C-terminus) with aurkb (via N-terminus and kinase domain). Interacts (via N-terminus) with birc5.1, birc5.2, cdca8 and cdca9. Interacts with mtus1 (By similarity).
messages: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with aurkb/aurora-B, the N-terminus associated with cdca8/borealin and/or cdca9/dasra-A tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs aurkb/aurora-B toward substrates near microtubules. Activates aurkb.
messages: Midbody
messages: Nucleus
messages: Originally predicted to contain a coiled coil domain but shown to contain a stable SAH domain instead.
messages: The INbox mediates interaction with aurkb/aurora-B.
messages: The SAH (single alpha-helix) region is characterized by a high content of charged residues which are predicted to stabilize the alpha-helical structure by ionic bonds. It can refold after extension suggesting an in vivo force-dependent function. The isolated SAH domain is monomeric.
messages: centromere
messages: kinetochore
messages: spindle

8355:MGC75753.S
gene id: 8355:MGC75753.S
uniprot id: A0A974HMK8
uniprot id: Q5EAW3
names: Similarity
messages: Belongs to the BTG family.

8355:tada2a.L
gene id: 8355:tada2a.L
uniprot id: A0A8J0UCA0
names: Subcellular Location Annotation
messages: Nucleus

8355:ackr3.L
gene id: 8355:ackr3.L
uniprot id: A0A974BZ92
uniprot id: Q8QFR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:hrh4.g2.L
gene id: 8355:hrh4.g2.L
uniprot id: A0A8J1KW97
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:ocm4.7.L
gene id: 8355:ocm4.7.L
uniprot id: A0A974H455
uniprot id: Q8AVP4
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

8355:LOC108719480
gene id: 8355:LOC108719480
uniprot id: A0A8J0VIA0
uniprot id: A0A8J1MNJ6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC121395349
gene id: 8355:LOC121395349
uniprot id: A0A8J1L7R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane

8355:LOC108704300
gene id: 8355:LOC108704300
uniprot id: A0A8J0U729
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:XB985134.L
gene id: 8355:XB985134.L
uniprot id: A0A1L8FZF1
uniprot id: A0A8J1KYT5
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108712258
gene id: 8355:LOC108712258
uniprot id: A0A8J1MQ23
uniprot id: A0A8J1MQ77
uniprot id: A0A8J1MR27
uniprot id: A0A8J1MSA3
names: Similarity
messages: Belongs to the JARID1 histone demethylase family.

8355:myh13.S
gene id: 8355:myh13.S
uniprot id: A0A1L8F450
uniprot id: A0A974C5K9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8355:LOC108697160
gene id: 8355:LOC108697160
uniprot id: A0A1L8FE25
uniprot id: A0A974CBV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108716394
gene id: 8355:LOC108716394
uniprot id: A0A1L8GCV1
uniprot id: A0A974CZC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8355:kif5c.S
gene id: 8355:kif5c.S
uniprot id: A0A1L8EP18
uniprot id: A0A974H1J2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8355:LOC108718901
gene id: 8355:LOC108718901
uniprot id: A0A8J0VJ17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

8355:ube2t.S
gene id: 8355:ube2t.S
uniprot id: A0A974DHL9
uniprot id: Q7ZY08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in DNA repair.
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Nucleus

8355:LOC108703962
gene id: 8355:LOC108703962
uniprot id: A0A8J1LUB7
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8355:LOC121402847
gene id: 8355:LOC121402847
uniprot id: A0A8J1MUI3
uniprot id: A0A8J1MW09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8355:LOC108707079
gene id: 8355:LOC108707079
uniprot id: A0A1L8HQ06
uniprot id: A0A974DWJ5
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

8355:irf10.L
gene id: 8355:irf10.L
uniprot id: A0A1L8ET99
uniprot id: A0A974BXD6
names: Subcellular Location Annotation
messages: Nucleus

8355:chit1.S
gene id: 8355:chit1.S
uniprot id: A0A974DGZ9
uniprot id: Q6GP67
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

8355:LOC121395814
gene id: 8355:LOC121395814
uniprot id: A0A8J1LB34
names: Subcellular Location Annotation
messages: acrosome

8355:cox11.L
gene id: 8355:cox11.L
uniprot id: A0A1L8G040
uniprot id: A0A974CRD2
names: Function
names: Subcellular Location Annotation
messages: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
messages: Mitochondrion inner membrane

8355:dtnbp1.L
gene id: 8355:dtnbp1.L
uniprot id: A0A8J0VHN9
uniprot id: Q6DF99
names: Similarity
messages: Belongs to the dysbindin family.

8355:LOC121401167
gene id: 8355:LOC121401167
uniprot id: A0A8J1MIV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8355:pdia6.S
gene id: 8355:pdia6.S
uniprot id: A0A974CUI3
uniprot id: Q7ZWN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Melanosome

8355:LOC108713455
gene id: 8355:LOC108713455
uniprot id: A0A8J1MWT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the catalase family.
messages: Peroxisome

8355:ist1.L
gene id: 8355:ist1.L
uniprot id: A0A1L8GKU1
uniprot id: A0A8J1MWF2
uniprot id: A0A974D5D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IST1 family.
messages: Cytoplasmic vesicle
messages: Nucleus envelope

8355:LOC108709433
gene id: 8355:LOC108709433
uniprot id: A0A8J1MD98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

8355:ern2.S
gene id: 8355:ern2.S
uniprot id: Q6GPM2
names: Subcellular Location Annotation
messages: Membrane

8355:cyb5r1.L
gene id: 8355:cyb5r1.L
uniprot id: A0A8J1M856
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

8355:cadm1.S
gene id: 8355:cadm1.S
uniprot id: A0A1L8FFV2
uniprot id: A0A8J0TCG8
uniprot id: A0A8J1LCN9
uniprot id: A0A8J1LCR8
uniprot id: A0A8J1LCX2
uniprot id: A0A8J1LE99
uniprot id: A0A8J1LF71
uniprot id: A0A8J1LF76
uniprot id: A0A974CC16
names: Similarity
messages: Belongs to the nectin family.

8355:slc16a6.S
gene id: 8355:slc16a6.S
uniprot id: A0A1L8EN87
uniprot id: A0A974H1B6
names: Subcellular Location Annotation
messages: Membrane

8355:cyp11a1.S
gene id: 8355:cyp11a1.S
uniprot id: A0A1L8GTC0
uniprot id: A0A8J0V0L4
uniprot id: A0A8J1MR68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
messages: Belongs to the cytochrome P450 family.
messages: Mitochondrion inner membrane

8355:sult4a1.L
gene id: 8355:sult4a1.L
uniprot id: A0A974DA59
uniprot id: Q68EV3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8355:fbn1.L
gene id: 8355:fbn1.L
uniprot id: A0A1L8H0J8
uniprot id: A0A974HT78
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8355:LOC108700535
gene id: 8355:LOC108700535
uniprot id: A0A8J1LM63
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

8355:cks2.L
gene id: 8355:cks2.L
uniprot id: A0A974E084
uniprot id: A3KNE9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

8355:faslg.L
gene id: 8355:faslg.L
uniprot id: B6F0V6
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8355:LOC108717528
gene id: 8355:LOC108717528
uniprot id: A0A1L8G0P0
uniprot id: A0A974HGS1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:nasp.S
gene id: 8355:nasp.S
uniprot id: A0A1L8GFM0
uniprot id: A0A974D090
uniprot id: P06180
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NASP family.
messages: Nucleus
messages: This protein is involved in nucleosome assembly. It is bound to H3 and H4 in the absence of DNA, but released from H3 and H4 in the presence of DNA.

8355:LOC108697803
gene id: 8355:LOC108697803
uniprot id: A0A8J0TFC1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8355:camk2g.S
gene id: 8355:camk2g.S
uniprot id: A0A8J0T4H8
uniprot id: A0A8J0T4I3
uniprot id: A0A8J0T4I9
uniprot id: A0A8J0T4J6
uniprot id: A0A8J0T4K1
uniprot id: A0A8J0TAP9
uniprot id: A0A8J0TAQ4
uniprot id: A0A8J0TCQ2
uniprot id: A0A8J0TCQ7
uniprot id: A0A8J0TCR5
uniprot id: A0A8J0TCS2
uniprot id: A0A8J0TDD1
uniprot id: A0A8J0TDD6
uniprot id: A0A8J0TDE1
uniprot id: A0A8J0TDE7
uniprot id: A0A8J0TDF4
uniprot id: A0A8J0TE25
uniprot id: A0A8J0TE31
uniprot id: A0A8J0TE36
uniprot id: A0A8J0TE41
uniprot id: A0A8J1L9W2
uniprot id: A0A8J1L9W8
uniprot id: A0A8J1L9X2
uniprot id: A0A8J1L9X6
uniprot id: A0A8J1LA00
uniprot id: A0A8J1LA04
uniprot id: A0A8J1LBG5
uniprot id: A0A8J1LBH0
uniprot id: A0A8J1LCE7
uniprot id: Q801N3
uniprot id: Q9DG00
uniprot id: Q9DG01
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

8355:rnf182.S
gene id: 8355:rnf182.S
uniprot id: Q6INB3
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that mediates the ubiquitination of atp6v0c and targets it to degradation via the ubiquitin-proteasome pathway.
messages: Interacts with ATP6V0C.
messages: Membrane
messages: The RING-type zinc finger domain is required for E3 ligase activity.

8355:tmod3.S
gene id: 8355:tmod3.S
uniprot id: A0A1L8GSW1
uniprot id: Q7ZWK9
names: Subcellular Location Annotation
messages: cytoskeleton

8355:zpr1.L
gene id: 8355:zpr1.L
uniprot id: A0A974CFQ8
uniprot id: B1H1S5
names: Similarity
messages: Belongs to the ZPR1 family.

8355:kcnf1.S
gene id: 8355:kcnf1.S
uniprot id: A0A1L8G5I5
uniprot id: A0A974HIM6
names: Subcellular Location Annotation
messages: Membrane

8355:atxn3.L
gene id: 8355:atxn3.L
uniprot id: A0A8J0TGK1
uniprot id: A0A8J1LHX0
uniprot id: A0A8J1LJS6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8355:plxnb1.L
gene id: 8355:plxnb1.L
uniprot id: A0A1L8GPZ4
uniprot id: A0A974HPP1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

8355:ezh2.S
gene id: 8355:ezh2.S
uniprot id: A0A8J0VIK0
uniprot id: A0A8J0VKW1
uniprot id: Q4V863
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.
messages: Component of the prc2/eed-ezh2 complex.
messages: Nucleus
messages: Polycomb group (PcG) protein. Catalytic subunit of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. May regulate the circadian clock via histone methylation at the promoter of the circadian genes.

8355:clstn2.L
gene id: 8355:clstn2.L
uniprot id: A0A8J1KPV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsyntenin family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Postsynaptic cell membrane

8355:sh2b1.S
gene id: 8355:sh2b1.S
uniprot id: A0A8J1M0E2
names: Similarity
messages: Belongs to the SH2B adapter family.

8355:gpr158.L
gene id: 8355:gpr158.L
uniprot id: A0A1L8FVG5
uniprot id: A0A974HF16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8355:myoz3.S
gene id: 8355:myoz3.S
uniprot id: A0A1L8GR63
names: Similarity
messages: Belongs to the myozenin family.

8355:ubtf.L
gene id: 8355:ubtf.L
uniprot id: P25979
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus
messages: UBF recognizes the ribosomal RNA gene promotor and activates transcription mediated by RNA polymerase I through cooperative interactions with the species-specific factor SL1. It binds specifically to the upstream control element.
messages: XUBF consists of 2 polypeptides of 82 and 85 kDa, encoded by the same or closely related genes.

8355:LOC108705285
gene id: 8355:LOC108705285
uniprot id: A0A8J1LYV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8355:LOC108719187
gene id: 8355:LOC108719187
uniprot id: A0A1L8FYF6
uniprot id: A0A8J0VHB8
uniprot id: A0A8J0VJY1
uniprot id: A0A8J0VKZ8
uniprot id: A0A8J0VP51
uniprot id: A0A974CN92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spire family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytoskeleton

8355:LOC108708891
gene id: 8355:LOC108708891
uniprot id: A0A1L8H644
uniprot id: A0A974DJ63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:upk1a.L
gene id: 8355:upk1a.L
uniprot id: A0A1L8FPJ0
uniprot id: A0A974CHJ0
uniprot id: A0A974CHP1
uniprot id: Q6DDZ0
names: Subcellular Location Annotation
messages: Membrane

8355:zfpl1.L
gene id: 8355:zfpl1.L
uniprot id: A0A974D3T7
uniprot id: A1L2S8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZFPL1 family.
messages: Membrane
messages: Required for cis-Golgi integrity and efficient ER to Golgi transport.
messages: The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.
messages: cis-Golgi network membrane

8355:gdf15.L
gene id: 8355:gdf15.L
uniprot id: A0A8J0V1Q7
names: Similarity
messages: Belongs to the TGF-beta family.

8355:LOC108709437
gene id: 8355:LOC108709437
uniprot id: A0A1L8H6M9
uniprot id: A0A8J1MF87
uniprot id: A0A974DGV3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: synaptic vesicle membrane

8355:LOC108703864
gene id: 8355:LOC108703864
uniprot id: A0A8J0U393
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

8355:itgae.L
gene id: 8355:itgae.L
uniprot id: A0A1L8HD32
uniprot id: A0A8J1M950
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

8355:LOC108702263
gene id: 8355:LOC108702263
uniprot id: A0A8J0TYC3
names: Similarity
messages: Belongs to the ARTD/PARP family.

8355:XB5734924.S
gene id: 8355:XB5734924.S
uniprot id: A0A1L8HLT1
uniprot id: A0A974DS35
names: Similarity
messages: Belongs to the MS4A family.

8355:mbd1.S
gene id: 8355:mbd1.S
uniprot id: A0A8J1LMB3
names: Subcellular Location Annotation
messages: Nucleus

8355:hspa14.S
gene id: 8355:hspa14.S
uniprot id: A2VD93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Component of ribosome-associated complex (RAC).
messages: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state.
messages: cytosol

8355:fbxo45.L
gene id: 8355:fbxo45.L
uniprot id: A0A1L8GBA4
uniprot id: A0A974HKH6
names: Similarity
messages: Belongs to the FBXO45/Fsn family.

8355:XB5993342.S
gene id: 8355:XB5993342.S
uniprot id: A0A1L8GEP3
uniprot id: A0A974CYU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IST1 family.
messages: Cytoplasmic vesicle
messages: Nucleus envelope

8355:ptbp1.L
gene id: 8355:ptbp1.L
uniprot id: A0A8J0U6Y5
uniprot id: A0A8J1LQ47
uniprot id: Q9PTS5
names: Subcellular Location Annotation
messages: Nucleus

8355:hspb8.L
gene id: 8355:hspb8.L
uniprot id: Q7SYX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Displays temperature-dependent chaperone activity.

8355:cnot3.L
gene id: 8355:cnot3.L
uniprot id: A0A1L8FMY0
uniprot id: A0A8J0T367
uniprot id: A0A8J0T373
uniprot id: A0A8J0T9J9
uniprot id: A0A8J0T9K4
uniprot id: A0A8J0TBL0
uniprot id: A0A8J0TBL2
uniprot id: A0A8J0TC23
uniprot id: A0A8J0TC29
uniprot id: A0A8J0TC34
uniprot id: A0A8J0TCT8
uniprot id: A0A974CGM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT2/3/5 family.
messages: Cytoplasm
messages: Nucleus

8355:LOC121402230
gene id: 8355:LOC121402230
uniprot id: A0A8J1MSH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8355:nodal.S
gene id: 8355:nodal.S
uniprot id: A0A1L8FF18
uniprot id: A0A974H9V3
names: Similarity
messages: Belongs to the TGF-beta family.

8355:sgsm3.L
gene id: 8355:sgsm3.L
uniprot id: A0A1L8GNS5
uniprot id: A0A974D4K8
names: Similarity
messages: Belongs to the small G protein signaling modulator family.

8355:XB22164552.L
gene id: 8355:XB22164552.L
uniprot id: A3KNF4
names: Similarity
messages: Belongs to the cystatin family.

8355:ctbp2l.L
gene id: 8355:ctbp2l.L
uniprot id: A0A1L8GY01
uniprot id: A0A8J1MM99
uniprot id: A0A974DCA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

8355:LOC108705845
gene id: 8355:LOC108705845
uniprot id: A0A8J1KIF6
uniprot id: A0A8J1KLL6
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:vsx2.S
gene id: 8355:vsx2.S
uniprot id: A0A1L8F0U1
uniprot id: A0A8J1LNV2
uniprot id: A0A8J1LNY7
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108716888
gene id: 8355:LOC108716888
uniprot id: A0A1L8G9G6
uniprot id: A0A974CXC3
names: Subcellular Location Annotation
messages: Membrane

8355:tmem150c.L
gene id: 8355:tmem150c.L
uniprot id: A0A1L8HVW1
uniprot id: A0A974I332
names: Subcellular Location Annotation
messages: Membrane

8355:dync1li2.L
gene id: 8355:dync1li2.L
uniprot id: Q0P3S2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

8355:mb21d2.S
gene id: 8355:mb21d2.S
uniprot id: A0A310TPJ3
uniprot id: A0A974BQZ6
names: Similarity
messages: Belongs to the mab-21 family.

8355:gpr87.S
gene id: 8355:gpr87.S
uniprot id: A0A1L8G4G6
uniprot id: A0A974HIE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:trmt1.L
gene id: 8355:trmt1.L
uniprot id: A0A8J1MG95
uniprot id: B1H1T2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

8355:htr1a.L
gene id: 8355:htr1a.L
uniprot id: Q98998
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.
messages: Cell membrane
messages: First expressed in the rostral part of the brain stem at stage 22. At later stages of development, expression is localized to serotonergic neurons. The expression pattern changes in the tadpole of stage 41 where, in addition to serotonergic neurons, expression is also localized to the inner nuclear layer (INL) of the developing retina. This expression pattern continues through to the start of metamorphosis (stage 46). In adults, expressed in the brain, in particular the telencephalon, diencephalon and mesencephalon. In the telencephalic region, expression is localized to the lateral, dorsal and medial pallium, and in the striatum, septum and amygdala. In the mesencephalic region, expression is strongest in the optic tectum and torus semicircularis with moderate levels of expression in tegmental nuclei. In diencephalon, localized to the dorsal and ventral thalamus and the preoptic area of the hypothalamus.
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity and behavior. Activation of the receptor may play a role in the exit from G0 phase and in promoting DNA synthesis.
messages: dendrite

8355:gpx4.S
gene id: 8355:gpx4.S
uniprot id: A0A8J0QEN5
uniprot id: Q32NS6
names: Similarity
messages: Belongs to the glutathione peroxidase family.

8355:dda1.L
gene id: 8355:dda1.L
uniprot id: A0A8J0QFA1
uniprot id: Q6INY2
names: Similarity
messages: Belongs to the DDA1 family.

8355:mrps25.L
gene id: 8355:mrps25.L
uniprot id: A0A974D7V8
uniprot id: A5D8M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS25 family.
messages: Mitochondrion

8355:LOC108711592
gene id: 8355:LOC108711592
uniprot id: A0A1L8H1T8
uniprot id: A0A8J0UKZ9
uniprot id: A0A8J0UT09
uniprot id: A0A974DDH2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:arpp19.L
gene id: 8355:arpp19.L
uniprot id: A0A8J0UFR1
uniprot id: A0A974DCT8
uniprot id: Q6DEB4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Interacts (when phosphorylated at Ser-67) with ppp2r2d.
messages: Phosphorylation at Ser-67 by gwl during mitosis is essential for interaction with ppp2r2d (PR55-delta) and subsequent inactivation of PP2A. Phosphorylated by PKA.
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with ppp2r2d (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase.

8355:tent5a.L
gene id: 8355:tent5a.L
uniprot id: Q08AY7
names: Similarity
messages: Belongs to the TENT family.

8355:tomm20.L
gene id: 8355:tomm20.L
uniprot id: A0A1L8G8K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

8355:LOC108699412
gene id: 8355:LOC108699412
uniprot id: A0A8J0TDX1
uniprot id: A0A8J0TMH6
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

8355:stx10.L
gene id: 8355:stx10.L
uniprot id: Q6GM45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

8355:LOC108709281
gene id: 8355:LOC108709281
uniprot id: A0A1L8H5J9
uniprot id: A0A8J0UJJ7
uniprot id: A0A974DGA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

8355:tada2b.L
gene id: 8355:tada2b.L
uniprot id: A0A974I313
uniprot id: Q6NRB5
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional coactivator.

8355:LOC121400930
gene id: 8355:LOC121400930
uniprot id: A0A8J1MGP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108706548
gene id: 8355:LOC108706548
uniprot id: A0A8J0U7T2
uniprot id: A0A8J1M0T0
names: Similarity
messages: Belongs to the LDB family.

8355:zc3h12c.S
gene id: 8355:zc3h12c.S
uniprot id: A0A1L8HAW9
names: Similarity
messages: Belongs to the ZC3H12 family.

8355:epdr1.L
gene id: 8355:epdr1.L
uniprot id: A0A1L8FWX4
uniprot id: A0A974CNW2
names: Similarity
messages: Belongs to the ependymin family.

8355:litaf.L
gene id: 8355:litaf.L
uniprot id: A0A1L8EXI1
uniprot id: A0A974C033
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

8355:homer2.L
gene id: 8355:homer2.L
uniprot id: A0A1L8H0M4
uniprot id: A0A974DCN1
uniprot id: Q7ZWP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

8355:miga1.L
gene id: 8355:miga1.L
uniprot id: A0A1L8GLN5
uniprot id: A0A974D5Y2
names: Similarity
messages: Belongs to the mitoguardin family.

8355:LOC108706474
gene id: 8355:LOC108706474
uniprot id: A0A1L8HKA1
uniprot id: A0A8J1M0K7
uniprot id: A0A8J1M2J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane

8355:hmga2.S
gene id: 8355:hmga2.S
uniprot id: A0A8J0USU7
uniprot id: A0A8J0UXC2
uniprot id: A0A974DAN8
uniprot id: Q08AX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

8355:LOC121398130
gene id: 8355:LOC121398130
uniprot id: A0A8J1LT22
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:jmy.S
gene id: 8355:jmy.S
uniprot id: A0A8J1M436
names: Subcellular Location Annotation
messages: Membrane

8355:gbf1.L
gene id: 8355:gbf1.L
uniprot id: A0A1L8FJX2
uniprot id: A0A8J1L5D9
uniprot id: A0A8J1L5E5
uniprot id: A0A8J1L5E6
uniprot id: A0A8J1L5H1
uniprot id: A0A8J1L754
uniprot id: A0A8J1L759
uniprot id: A0A8J1L858
names: Subcellular Location Annotation
messages: Golgi apparatus

8355:nup133.S
gene id: 8355:nup133.S
uniprot id: A0A1L8GS04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin Nup133 family.
messages: nuclear pore complex

8355:LOC108707491
gene id: 8355:LOC108707491
uniprot id: A0A1L8HES0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

8355:LOC108701023
gene id: 8355:LOC108701023
uniprot id: A0A1L8ETQ4
uniprot id: A0A974H2Q3
names: Similarity
messages: Belongs to the RAMP family.

8355:LOC108717482
gene id: 8355:LOC108717482
uniprot id: A0A1L8G511
uniprot id: A0A974CUF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

8355:LOC121403689
gene id: 8355:LOC121403689
uniprot id: A0A8J1N1Y5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
messages: Homodimer; disulfide-linked.
messages: Membrane

8355:rnf111.S
gene id: 8355:rnf111.S
uniprot id: A0A8J1MPF0
uniprot id: A0A8J1MPJ8
uniprot id: A0A8J1MQF7
uniprot id: A0A8J1MQJ8
uniprot id: Q6NRV8
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Arkadia family.
messages: Binds free ubiquitin non-covalently via its RING-type zinc finger. Ubiquitin-binding leads to enhance the E3 ubiquitin-protein ligase activity by stabilizing the ubiquitin-conjugating enzyme E2 (donor ubiquitin) in the 'closed' conformation and activating ubiquitin transfer.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the smad2/smad3 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as smad7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP. Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (By similarity). The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity).
messages: Monomer.
messages: Nucleus
messages: PML body
messages: The RING-type zinc finger mediates the E3 ubiquitin-protein ligase activity and binds directly to free ubiquitin (By similarity). Non-covalent ubiquitin-binding stabilizes the ubiquitin-conjugating enzyme E2 (donor ubiquitin) in the 'closed' conformation and stimulates ubiquitin transfer (By similarity).
messages: The SUMO interaction motifs (SIMs) mediates the binding to polysumoylated substrate.

8355:adam11.S
gene id: 8355:adam11.S
uniprot id: A0A1L8EL35
uniprot id: A0A974H0A2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:cryl1.S
gene id: 8355:cryl1.S
uniprot id: A0A8J0UKX1
uniprot id: A0A8J0UM84
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

8355:LOC108703945
gene id: 8355:LOC108703945
uniprot id: A0A8J0TVQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8355:bcar1.L
gene id: 8355:bcar1.L
uniprot id: A0A8J0USV2
uniprot id: A0A8J1MTI7
uniprot id: A0A8J1MVV9
uniprot id: Q6PAF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

8355:rnf4.L
gene id: 8355:rnf4.L
uniprot id: Q5HZL0
names: Subcellular Location Annotation
messages: Nucleus

8355:ppp1r1b.S
gene id: 8355:ppp1r1b.S
uniprot id: A0A1L8EKM5
uniprot id: A0A974H056
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

8355:slc4a10.L
gene id: 8355:slc4a10.L
uniprot id: A0A1L8EVZ9
uniprot id: A0A8J0TPE0
uniprot id: A0A8J1LQW9
uniprot id: A0A8J1LR12
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

8355:rax2.S
gene id: 8355:rax2.S
uniprot id: A0A974DT16
uniprot id: Q0ZLI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

8355:dcps.L
gene id: 8355:dcps.L
uniprot id: Q4KLD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HIT family.
messages: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.
messages: Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.
messages: Nucleus

8355:scg2.L
gene id: 8355:scg2.L
uniprot id: A0A1L8GB41
uniprot id: A0A8J0V8N3
uniprot id: Q5U578
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Secreted

8355:slco2a1.S
gene id: 8355:slco2a1.S
uniprot id: A0A1L8G508
uniprot id: A0A974HI94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

8355:LOC108707272
gene id: 8355:LOC108707272
uniprot id: A0A8J1M428
uniprot id: A0A8J1M429
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8355:limk2.L
gene id: 8355:limk2.L
uniprot id: A0A8J0TXD1
uniprot id: A0A8J0TXG5
uniprot id: Q8QHM0
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

8355:fkbp4.L
gene id: 8355:fkbp4.L
uniprot id: A0A974D9T0
uniprot id: Q6NRL7
names: Subcellular Location Annotation
messages: Mitochondrion
messages: cytoskeleton
messages: cytosol

8355:heatr5a.L
gene id: 8355:heatr5a.L
uniprot id: A0A1L8FAV8
uniprot id: A0A8J0TMY3
uniprot id: A0A974C9W4
names: Similarity
messages: Belongs to the HEATR5 family.

8355:cmtm7.L
gene id: 8355:cmtm7.L
uniprot id: A0A974HFE7
uniprot id: Q6DFH1
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108700640
gene id: 8355:LOC108700640
uniprot id: A0A1L8F107
uniprot id: A0A974C2I2
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

8355:gstcd.L
gene id: 8355:gstcd.L
uniprot id: Q6DDT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSTCD family.
messages: Cytoplasm

8355:atp2a3.S
gene id: 8355:atp2a3.S
uniprot id: A0A1L8H8B2
uniprot id: A0A8J1MEB7
uniprot id: A0A974HVX7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

8355:LOC121398254
gene id: 8355:LOC121398254
uniprot id: A0A8J1LWL3
names: Subcellular Location Annotation
messages: Secreted

8355:slc30a7.S
gene id: 8355:slc30a7.S
uniprot id: Q52KD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Cytoplasmic vesicle
messages: Golgi apparatus membrane
messages: Homooligomer.
messages: Mitochondrion
messages: Sarcoplasmic reticulum
messages: Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway. By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases.
messages: trans-Golgi network

8355:LOC108708905
gene id: 8355:LOC108708905
uniprot id: A0A8J1MDD0
uniprot id: A0A8J1MF75
names: Similarity
messages: Belongs to the WD repeat EBI family.

8355:dpp3.L
gene id: 8355:dpp3.L
uniprot id: A0A1L8GJX9
uniprot id: Q6DE90
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M49 family.
messages: Binds 1 zinc ion per subunit.

8355:mylk.S
gene id: 8355:mylk.S
uniprot id: A0A8J1LXJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cell membrane

8355:adcy9.S
gene id: 8355:adcy9.S
uniprot id: A0A8J1M0C2
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

8355:snx18.L
gene id: 8355:snx18.L
uniprot id: A0A8J1M5F4
uniprot id: Q6DDP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

8355:ube2u.L
gene id: 8355:ube2u.L
uniprot id: A0A1L8GLX6
uniprot id: A0A974D559
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8355:ahdc1.S
gene id: 8355:ahdc1.S
uniprot id: A0A8J0UKG3
names: Subcellular Location Annotation
messages: Nucleus

8355:nog2.L
gene id: 8355:nog2.L
uniprot id: A0A974H4M2
uniprot id: Q5EC15
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the noggin family.
messages: Homodimer.
messages: Secreted

8355:crx.S
gene id: 8355:crx.S
uniprot id: A0A1L8F3X7
uniprot id: Q9PVM0
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed at low level from stage 1 to stage 9, when expression levels increase.
messages: Initially expressed in the Spemann organizer region of early gastrula embryos. Expression then becomes localized to the anterior region; confined to the cement gland anlage at stages 19-25 and localized to the forebrain, optic vesicle and otocyst at stage 28.
messages: Nucleus
messages: Transcription factor involved in anterior and eye development. Promotes the differentiation of both rod and cone photoreceptors cells in the retina. Together with other retinal homeobox proteins, acts as an effector of a cellular clock which, depending on cell cycle progression, establishes the generation of distinct retinal neuronal cell types. Acts synergistically with nrl to activate the rhodopsin promoter (By similarity). Promotes the formation of anterior regions and represses the formation of posterior structures during development.

8355:lipc.L
gene id: 8355:lipc.L
uniprot id: A0A1L8H0B2
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:LOC108708897
gene id: 8355:LOC108708897
uniprot id: A0A1L8H6D7
uniprot id: A0A974DH53
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:LOC108706964
gene id: 8355:LOC108706964
uniprot id: A0A1L8HP50
uniprot id: A0A8J0U1D8
uniprot id: A0A8J0U8F6
uniprot id: A0A974I103
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

8355:rab11fip3.S
gene id: 8355:rab11fip3.S
uniprot id: A0A1L8EQS1
uniprot id: A0A8J0U2F0
uniprot id: A0A974BVV0
names: Subcellular Location Annotation
messages: Cleavage furrow
messages: Endosome membrane
messages: Membrane
messages: Midbody
messages: Recycling endosome membrane

8355:ube2e2
gene id: 8355:ube2e2
uniprot id: Q6DD28
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8355:cdc14b.L
gene id: 8355:cdc14b.L
uniprot id: A0A1L8HYG6
uniprot id: A0A8J0UYZ1
uniprot id: A0A8J0V314
uniprot id: A0A8J0V487
uniprot id: A0A8J0V493
uniprot id: A0A8J1KT75
uniprot id: A0A8J1KT81
uniprot id: A0A8J1KT85
uniprot id: A0A8J1KWC3
uniprot id: A0A974E237
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

8355:LOC108717866
gene id: 8355:LOC108717866
uniprot id: A0A8J0VGA4
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

8355:gnal.S
gene id: 8355:gnal.S
uniprot id: A0A8J0VL40
uniprot id: A0A8J0VM13
uniprot id: A0A8J0VPR4
uniprot id: Q90WN6
names: Similarity
messages: Belongs to the G-alpha family. G(s) subfamily.

8355:krt78.6.S
gene id: 8355:krt78.6.S
uniprot id: A0A1L8HA95
uniprot id: A0A974DJF4
names: Similarity
messages: Belongs to the intermediate filament family.

8355:crygdl.4.L
gene id: 8355:crygdl.4.L
uniprot id: A0A8J0TCU3
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:LOC108716895
gene id: 8355:LOC108716895
uniprot id: A0A1L8G9H5
uniprot id: A0A974CW54
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

8355:hoxa7.L
gene id: 8355:hoxa7.L
uniprot id: A0A974CLR8
uniprot id: B7ZRU4
uniprot id: P09071
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: By derriere.
messages: Expressed exclusively in the posterior mesoderm and ectoderm of early Xenopus embryos.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

8355:kat6a.L
gene id: 8355:kat6a.L
uniprot id: A0A8J1MMK0
uniprot id: A0A8J1MNI8
uniprot id: A0A8J1MPM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

8355:LOC108703893
gene id: 8355:LOC108703893
uniprot id: A0A8J0TVL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

8355:LOC108711385
gene id: 8355:LOC108711385
uniprot id: A0A8J1MLR0
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

8355:LOC121395587
gene id: 8355:LOC121395587
uniprot id: A0A8J1L703
uniprot id: A0A8J1L8P4
uniprot id: A0A8J1L9N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0688 family.
messages: Nucleus

8355:erlec1.L
gene id: 8355:erlec1.L
uniprot id: A0A1L8G651
uniprot id: A0A8J0V9A5
uniprot id: A0A8J1KQ81
uniprot id: A0A974CV21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OS-9 family.
messages: Endoplasmic reticulum lumen
messages: Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.

8355:eif4a3.1.S
gene id: 8355:eif4a3.1.S
uniprot id: O42226
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions (By similarity). Involved in craniofacial development (By similarity). When overexpressed, induces epidermis in dissociated cells that would otherwise adopt a neural fate, a process that requires an active BMP signaling pathway (PubMed:9334272).
messages: Belongs to the DEAD box helicase family.
messages: Cytoplasm
messages: Expressed between blastula and neural plate stages. Detected in the ventral ectoderm of the gastrula, the region fated to give rise to epidermis and a site of active BMP signaling.
messages: Identified in the spliceosome C complex. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains casc3, eif4a3, magoh and rbm8a.
messages: Nucleus
messages: Nucleus speckle

8355:LOC108698644
gene id: 8355:LOC108698644
uniprot id: A0A1L8F909
uniprot id: A0A8J1LH87
uniprot id: A0A8J1LHR6
uniprot id: A0A8J1LII1
uniprot id: A0A8J1LJM0
uniprot id: A0A974C7N6
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

8355:pdilt.S
gene id: 8355:pdilt.S
uniprot id: A0A8J1LWU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

8355:LOC108713501
gene id: 8355:LOC108713501
uniprot id: A0A8J0UTZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

8355:cdc5l.L
gene id: 8355:cdc5l.L
uniprot id: A1A5J6
names: Similarity
messages: Belongs to the CEF1 family.

8355:XB5880541.S
gene id: 8355:XB5880541.S
uniprot id: A0A974CKW2
uniprot id: Q641E1
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:stx18.S
gene id: 8355:stx18.S
uniprot id: A0A1L8HKT5
uniprot id: A0A974DRN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

8355:irf3.L
gene id: 8355:irf3.L
uniprot id: Q7ZXG6
names: Subcellular Location Annotation
messages: Nucleus

8355:mgmt.L
gene id: 8355:mgmt.L
uniprot id: A0A1L8FJ53
names: Function
names: Similarity
messages: Belongs to the MGMT family.
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

8355:tmc5.S
gene id: 8355:tmc5.S
uniprot id: A0A1L8EQB1
uniprot id: A0A974H1Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

8355:id3.S
gene id: 8355:id3.S
uniprot id: A0A974DHV4
uniprot id: Q7SZ28
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer (By similarity). Heterodimer with other HLH proteins. Interacts (via HLH domain) with the bHLH protein hes4/hairy2 (via Orange domain). Interacts with stat3 (By similarity).
messages: Nucleus
messages: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Influences cell fate decisions in the embryo by sequestering and blocking the activity of the bHLH transcription factors that control these decisions. Inhibits the binding of myogenic bHLH-containing complexes to E-box DNA, thereby preventing activation of muscle-specific target genes. Also inhibits the activity of neurogenic factor neurod1/neuroD. Plays a role in cell cycle progression and survival of neural crest progenitors; binding to either hes4-B/hairy2b or stat3 blocks the formation of transcription factor complexes and the repressor function of hes4-B/hairy2B, to allow neural crest progenitors to differentiate. May play a role in the regulation of the circadian rhythm (By similarity).

8355:tm6sf1.L
gene id: 8355:tm6sf1.L
uniprot id: A0A974DD86
uniprot id: Q6DCP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM6SF family.
messages: Lysosome membrane
messages: May function as sterol isomerase.
messages: Membrane

8355:myo5b.S
gene id: 8355:myo5b.S
uniprot id: A0A8J1M4F0
uniprot id: A0A8J1M4F3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8355:eif3b.L
gene id: 8355:eif3b.L
uniprot id: Q569Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit B family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Stress granule

8355:tmem19.L
gene id: 8355:tmem19.L
uniprot id: A0A974DBP6
uniprot id: Q6IR76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

8355:entpd7.L
gene id: 8355:entpd7.L
uniprot id: A0A1L8FJK2
uniprot id: A0A974CFN2
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

8355:LOC108705420
gene id: 8355:LOC108705420
uniprot id: A0A8J0TYY9
names: Subcellular Location Annotation
messages: Membrane

8355:st6galnac6.L
gene id: 8355:st6galnac6.L
uniprot id: A0A8J1LI59
uniprot id: A0A8J1LKI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8355:st3gal6.L
gene id: 8355:st3gal6.L
uniprot id: A0A8J1M6B1
uniprot id: Q70D53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8355:LOC121393288
gene id: 8355:LOC121393288
uniprot id: A0A8J1KLR0
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:LOC108704562
gene id: 8355:LOC108704562
uniprot id: A0A8J1M1U6
uniprot id: A0A8J1M2Z0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:cluap1.L
gene id: 8355:cluap1.L
uniprot id: A0A1L8EYI0
uniprot id: A0A8J0TTQ2
uniprot id: A0A8J1LRL9
uniprot id: A0A974H499
uniprot id: Q5PPY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLUAP1 family.
messages: cilium

8355:LOC108704424
gene id: 8355:LOC108704424
uniprot id: A0A8J0U598
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

8355:c20orf27.S
gene id: 8355:c20orf27.S
uniprot id: A0A8J1M0R0
uniprot id: A0A8J1M2M1
names: Similarity
messages: Belongs to the ADISSP family.

8355:sema4c.S
gene id: 8355:sema4c.S
uniprot id: A0A1L8GRZ6
uniprot id: A0A974D9G0
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:selenop1.L
gene id: 8355:selenop1.L
uniprot id: A0A8J0QGR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selenoprotein P family.
messages: Secreted

8355:anxa4.S
gene id: 8355:anxa4.S
uniprot id: Q6GND2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Zymogen granule membrane

8355:xpr1.S
gene id: 8355:xpr1.S
uniprot id: A0A1L8GG71
uniprot id: A0A974D294
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYG1 (TC 2.A.94) family.
messages: Membrane

8355:XB5761350.S
gene id: 8355:XB5761350.S
uniprot id: Q5XH06
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:hdac1.L
gene id: 8355:hdac1.L
uniprot id: A0A974DMV1
uniprot id: Q91695
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Belongs to the histone deacetylase family. HD type 1 subfamily.
messages: Cytoplasm
messages: Expressed both maternally and zygotically. Accumulates in previtellogenic oocytes and is maintained at constant level throughout oogenesis and into early embryogenesis. Declines through gastrula to neurula. Not detectable between neurula and tailbud, nor in adult tissues other than ovary.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins. In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones.
messages: Nucleus
messages: Oocyte.
messages: Part of a large multiprotein complex that also contains RBBP4.

8355:slc7a8.S
gene id: 8355:slc7a8.S
uniprot id: A0A8J0TRD1
uniprot id: A0A974DW67
uniprot id: Q7ZWV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Cell membrane
messages: Membrane

8355:tmem47.L
gene id: 8355:tmem47.L
uniprot id: A0A974DQD6
uniprot id: Q6IP19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane
messages: Regulates cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly.
messages: adherens junction

8355:LOC108702502
gene id: 8355:LOC108702502
uniprot id: A0A8J0TYS5
uniprot id: A0A8J0U005
uniprot id: A0A8J1M298
names: Function
names: Subcellular Location Annotation
messages: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.
messages: cell cortex
messages: cytoskeleton

8355:pop5.L
gene id: 8355:pop5.L
uniprot id: A6H8I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

8355:c22orf39.L
gene id: 8355:c22orf39.L
uniprot id: A0A974BQJ2
uniprot id: A2BD89
names: Similarity
messages: Belongs to the UPF0545 family.

8355:eef2.1.L
gene id: 8355:eef2.1.L
uniprot id: Q7ZXP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Binds to 80S ribosomes (PubMed:36653451). Actively translating ribosomes show mutually exclusive binding of eIF5a (EIF5A or EIF5A2) and EEF2/eEF2 (By similarity). Interacts with serbp1; interaction sequesters eef2/eEF2 at the A-site of the ribosome, thereby blocking the interaction sites of the mRNA-tRNA complex, promoting ribosome stabilization and hibernation (By similarity). Interacts with habp4; interaction takes place at the A-site of hibernating ribosomes and promotes ribosome stabilization (PubMed:36653451).
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (By similarity). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (By similarity). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
messages: Cytoplasm
messages: Nucleus

8355:zdhhc21.S
gene id: 8355:zdhhc21.S
uniprot id: A0A1L8HP35
uniprot id: A0A8J0U8D3
uniprot id: A0A8J0U9N6
uniprot id: A0A974DUP0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:gpr61.S
gene id: 8355:gpr61.S
uniprot id: A0A1L8H6X0
uniprot id: A0A974DH13
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:LOC108716291
gene id: 8355:LOC108716291
uniprot id: A0A1L8GCZ0
uniprot id: A0A974CZE2
names: Subcellular Location Annotation
messages: Membrane

8355:vps16.S
gene id: 8355:vps16.S
uniprot id: A0A1L8HBP7
uniprot id: A0A974HX29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS16 family.
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: Vesicle

8355:lmnb2.L
gene id: 8355:lmnb2.L
uniprot id: P21910
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.
messages: Belongs to the intermediate filament family.
messages: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
messages: Nucleus inner membrane
messages: The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively.
messages: There are at least five different lamins in Xenopus: the somatic lamins L(I), L(II), and A; the oocyte germinal vesicle lamin L(III); and the male germ cells lamin l(IV).

8355:asf1a.L
gene id: 8355:asf1a.L
uniprot id: A0A974HJM9
uniprot id: Q69DB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ASF1 family.
messages: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (By similarity). Not critical for histone deposition during nucleosome assembly (PubMed:17576589).
messages: Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4 (By similarity). Interacts with hira and p60 (PubMed:17576589).
messages: Nucleus

8355:chst11.S
gene id: 8355:chst11.S
uniprot id: A0A1L8GUW0
uniprot id: A0A8J1MRZ4
uniprot id: A0A974DB46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:coq10a.L
gene id: 8355:coq10a.L
uniprot id: A0A8J1M5I2
uniprot id: A0A974DQF4
uniprot id: Q6DFA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Mitochondrion inner membrane
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity).
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

8355:wdr35.S
gene id: 8355:wdr35.S
uniprot id: A0A1L8G5F0
uniprot id: A0A974CSX6
names: Subcellular Location Annotation
messages: centrosome
messages: cilium basal body

8355:elp2.S
gene id: 8355:elp2.S
uniprot id: A0A1L8FS31
uniprot id: A0A974HDX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ELP2 family.
messages: Cytoplasm
messages: Nucleus

8355:myd88.S
gene id: 8355:myd88.S
uniprot id: Q5FWM2
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Activates expression of target genes in the Spemann organizer region during early embryonic development. Is required for normal axis formation (By similarity).
messages: Cytoplasm
messages: The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.

8355:mcl1.S
gene id: 8355:mcl1.S
uniprot id: A0A1L8F4J2
uniprot id: A0A974C4D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: nucleoplasm

8355:pcdhgc4.S
gene id: 8355:pcdhgc4.S
uniprot id: A0A1L8GVJ0
uniprot id: A0A8J0UYF3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:chd8.L
gene id: 8355:chd8.L
uniprot id: A0A1L8I025
uniprot id: A0A8J0V5F4
uniprot id: A0A974E2P1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily.
messages: Component of some MLL1/MLL complex.
messages: DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. May also act as a transcription activator by participating in efficient U6 RNA polymerase III transcription.
messages: Nucleus

8355:LOC121402057
gene id: 8355:LOC121402057
uniprot id: A0A8J1MPQ0
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108709367
gene id: 8355:LOC108709367
uniprot id: A0A1L8H651
uniprot id: A0A974HV65
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:pcsk4.L
gene id: 8355:pcsk4.L
uniprot id: Q5EE50
names: Similarity
messages: Belongs to the peptidase S8 family.

8355:st3gal4.L
gene id: 8355:st3gal4.L
uniprot id: A0A8J0T8Q0
uniprot id: A0A8J0T9M1
uniprot id: A0A8J1L4M7
uniprot id: A0A8J1L4Q1
uniprot id: A0A8J1L6D5
uniprot id: A0A974CFE8
uniprot id: Q4V814
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8355:relt.S
gene id: 8355:relt.S
uniprot id: A0A1L8HB37
uniprot id: A0A974HWT3
names: Similarity
messages: Belongs to the RELT family.

8355:nrde2.L
gene id: 8355:nrde2.L
uniprot id: A0A8J0TEL8
uniprot id: Q6IRN3
names: Similarity
messages: Belongs to the NRDE2 family.

8355:brinp1.S
gene id: 8355:brinp1.S
uniprot id: A0A1L8F247
uniprot id: A0A974C3Q4
names: Similarity
messages: Belongs to the BRINP family.

8355:rprd1b.S
gene id: 8355:rprd1b.S
uniprot id: Q0D258
names: Similarity
messages: Belongs to the UPF0400 (RTT103) family.

8355:crybg1.L
gene id: 8355:crybg1.L
uniprot id: A0A1L8G8X1
uniprot id: A0A8J0V827
uniprot id: A0A8J0VB17
uniprot id: A0A8J1KRS8
uniprot id: A0A974CV42
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:hhex.S
gene id: 8355:hhex.S
uniprot id: A0A1L8FEG0
uniprot id: A0A974HA46
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC443660
gene id: 8355:LOC443660
uniprot id: A0A8J1M929
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
messages: Nucleus

8355:LOC108697168
gene id: 8355:LOC108697168
uniprot id: A0A1L8FE15
uniprot id: A0A974CAT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:tnpo2.S
gene id: 8355:tnpo2.S
uniprot id: A0A8J0U4Y5
uniprot id: Q5XHG0
names: Subcellular Location Annotation
messages: Cytoplasm

8355:LOC108705581
gene id: 8355:LOC108705581
uniprot id: A0A8J0U7L6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:ahctf1.L
gene id: 8355:ahctf1.L
uniprot id: Q5U249
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELYS family.
messages: Cytoplasm
messages: Interacts with the Nup107-160 subcomplex of the NPC.
messages: Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex, which may in turn recruit membrane vesicles containing pom121 and tmem48/ndc1. Association with chromatin may require the presence of the mcm2-mcm7 complex, suggesting a mechanism for coordination of nuclear assembly and the inactivation of replication licensing.
messages: The N-terminus forms a highly conserved seven-bladed beta propeller decorated with long loops and mediates anchorage to the Nup107-160 subcomplex of the nuclear pore, synergistically with the central alpha domain. The disordered C-terminus is responsible for the interactions with chromatin (By similarity).
messages: nuclear pore complex
messages: nucleoplasm

8355:npm1.L
gene id: 8355:npm1.L
uniprot id: A0A8J0UMZ3
uniprot id: A0A974DA72
uniprot id: Q7SZ17
names: Similarity
messages: Belongs to the nucleoplasmin family.

8355:vti1b.S
gene id: 8355:vti1b.S
uniprot id: A0A1L8H759
uniprot id: A0A974HVI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

8355:LOC108699020
gene id: 8355:LOC108699020
uniprot id: A0A8J1LJV7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC494784
gene id: 8355:LOC494784
uniprot id: A0A974C9Y4
uniprot id: Q63ZL1
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:ccng1.L
gene id: 8355:ccng1.L
uniprot id: A0A974DAP1
uniprot id: Q802B8
names: Similarity
messages: Belongs to the cyclin family.

8355:gck.S
gene id: 8355:gck.S
uniprot id: A0A8J0UZI5
names: Similarity
messages: Belongs to the hexokinase family.

8355:tnn.L
gene id: 8355:tnn.L
uniprot id: A0A1L8GML9
uniprot id: A0A974D3W3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8355:LOC108698359
gene id: 8355:LOC108698359
uniprot id: A0A8J1LGF4
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC108715673
gene id: 8355:LOC108715673
uniprot id: A0A1L8I028
uniprot id: A0A8J0V6K5
uniprot id: A0A8J0V7B5
uniprot id: A0A974E1G2
names: Similarity
messages: Belongs to the RUTBC family.

8355:gnptab.L
gene id: 8355:gnptab.L
uniprot id: A0A1L8GY18
uniprot id: A0A974HSC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the stealth family.
messages: Membrane

8355:sfrp4.L
gene id: 8355:sfrp4.L
uniprot id: A0A1L8FWW4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:lipg.L
gene id: 8355:lipg.L
uniprot id: A0A1L8I2X6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:scd.S
gene id: 8355:scd.S
uniprot id: A0A974CCN1
uniprot id: Q66IP8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

8355:fgf20.L
gene id: 8355:fgf20.L
uniprot id: A0A974DWN6
uniprot id: Q9PVY1
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

8355:foxj1.S
gene id: 8355:foxj1.S
uniprot id: A0A974BTF6
uniprot id: Q708W2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FOXJ1 family.
messages: Expressed in two independent areas of stage 10-11 embryos; in the dorsal blastopore lip (Spemann organizer) and shortly after in the ectodermal cells of the animal cap. As development proceeds, cells of the animal cap contribute to the epidermis and show a spotty pattern, which suggests expression in ciliated epidermal cells. Distribution of these cells is uniform in the trunk area of the embryo but more random in the head, being practically absent in the cement gland and olfactory placode. The spotted pattern becomes more dispersed as embryos grow in size. Due to cell movements during gastrulation, expression in the dorsal lip becomes located in the dorsal midline with expression restricted to the neuroectoderm. Expressed transiently in cells of the newly formed neural floor plate in the tail of older tadpoles.
messages: Expression begins during gastrulation, increases continuously until stage 26 and then becomes slightly down-regulated during the following stages.
messages: Key transcription factor required for motile ciliogenesis. Activates genes essential for motile cilia formation and function. Required for ciliogenesis in multiciliated cells.
messages: Nucleus

8355:cux1.S
gene id: 8355:cux1.S
uniprot id: A0A1L8H698
uniprot id: A0A8J0UIF4
uniprot id: A0A8J0UML7
uniprot id: A0A974HVK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASP family.
messages: Belongs to the CUT homeobox family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Nucleus

8355:LOC121399924
gene id: 8355:LOC121399924
uniprot id: A0A8J1M893
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:ascc3.L
gene id: 8355:ascc3.L
uniprot id: A0A1L8G9L1
uniprot id: A0A974HK49
names: Similarity
messages: Belongs to the helicase family.

8355:fastkd1.L
gene id: 8355:fastkd1.L
uniprot id: Q6GQ66
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAST kinase family.
messages: May regulate the stability of some mitochondrial mRNA species.
messages: Mitochondrion
messages: The RAP domain seems to regulate mitochondrial mRNA levels.

8355:atf1.L
gene id: 8355:atf1.L
uniprot id: A0A974DS50
uniprot id: Q5HZP0
names: Subcellular Location Annotation
messages: Nucleus

8355:optc.S
gene id: 8355:optc.S
uniprot id: A0A1L8H6T4
uniprot id: A0A974HVE0
names: Similarity
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

8355:csk.L
gene id: 8355:csk.L
uniprot id: A0A1L8H049
uniprot id: A0A974HT79
uniprot id: O73786
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

8355:LOC121401069
gene id: 8355:LOC121401069
uniprot id: A0A8J1MK00
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:pde6h.L
gene id: 8355:pde6h.L
uniprot id: A0A974D5A5
uniprot id: Q6GLU4
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

8355:rtp3d.S
gene id: 8355:rtp3d.S
uniprot id: A0A1L8G414
uniprot id: A0A974HHX8
names: Subcellular Location Annotation
messages: Cytoplasmic ribonucleoprotein granule

8355:purb.L
gene id: 8355:purb.L
uniprot id: A0A974DD92
uniprot id: Q6PAC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: May bind repeated elements in single-stranded DNA and may participate in transcriptional and translational gene regulation.
messages: Nucleus

8355:spop.S
gene id: 8355:spop.S
uniprot id: A0A974BS94
uniprot id: Q0IHH9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tdpoz family.
messages: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.
messages: Homodimer. Part of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain CUL3 and SPOP, plus a target protein (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: The BTB (POZ) domain mediates dimerization and interaction with CUL3.
messages: The MATH domain mediates interaction with protein-ubiquitin ligase substrates.

8355:myb.L
gene id: 8355:myb.L
uniprot id: A0A8J1KNI8
uniprot id: A0A8J1KNJ7
uniprot id: A0A8J1KNJ9
uniprot id: A0A8J1KRM9
names: Subcellular Location Annotation
messages: Nucleus

8355:ptprn.L
gene id: 8355:ptprn.L
uniprot id: A0A1L8EVM3
uniprot id: A0A8J0TT34
uniprot id: A0A974H3V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
messages: Membrane
messages: secretory vesicle membrane

8355:LOC108697058
gene id: 8355:LOC108697058
uniprot id: A0A1L8FNZ4
uniprot id: A0A974HCW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

8355:ahcyl2.S
gene id: 8355:ahcyl2.S
uniprot id: A0A8J0UMQ7
uniprot id: A0A8J0UTH1
uniprot id: A0A8J0UUK8
uniprot id: A0A8J0UUN7
uniprot id: A0A8J0UY26
uniprot id: A0A8J1MP77
uniprot id: A0A8J1MRC7
uniprot id: Q68EX1
names: Cofactor
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.

8355:LOC108720028
gene id: 8355:LOC108720028
uniprot id: A0A1L8FS21
uniprot id: A0A974CJ34
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.
messages: Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.

8355:pex10.L
gene id: 8355:pex10.L
uniprot id: A0A1L8FM16
uniprot id: A0A974HC94
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of the PEX2-PEX10-PEX12 retrotranslocation channel.
messages: E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:35931083). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase (By similarity). When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation (By similarity).
messages: Membrane
messages: Peroxisome membrane
messages: The E3 ubiquitin-protein ligase activity is stimulated by PEX12.
messages: The three subunits of the retrotranslocation channel (PEX2, PEX10 and PEX12) coassemble in the membrane into a channel with an open 10 Angstrom pore. The RING-type zinc-fingers that catalyze PEX5 receptor ubiquitination are positioned above the pore on the cytosolic side of the complex.

8355:senp8.S
gene id: 8355:senp8.S
uniprot id: A0A1L8GTG2
uniprot id: A0A974D9Z4
uniprot id: Q6PCE7
names: Similarity
messages: Belongs to the peptidase C48 family.

8355:prrt1.L
gene id: 8355:prrt1.L
uniprot id: A0A1L8F8D5
uniprot id: A0A974H7K5
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8355:mpi.S
gene id: 8355:mpi.S
uniprot id: A0A1L8GT78
uniprot id: A0A8J0UWU0
uniprot id: A0A8J0UX16
uniprot id: A0A974HRA5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

8355:reep4.L
gene id: 8355:reep4.L
uniprot id: A0A1L8H222
uniprot id: A0A974HU37
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:p2ry1.S
gene id: 8355:p2ry1.S
uniprot id: A0A974CS89
uniprot id: Q90X57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:frem2.L
gene id: 8355:frem2.L
uniprot id: A0A1L8HIY1
uniprot id: A0A8J0UGW6
uniprot id: A0A974HZV3
names: Similarity
messages: Belongs to the FRAS1 family.

8355:LOC121394107
gene id: 8355:LOC121394107
uniprot id: A0A8J1KTG7
names: Subcellular Location Annotation
messages: interphotoreceptor matrix

8355:LOC121396357
gene id: 8355:LOC121396357
uniprot id: A0A1L8FE02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:chst2.S
gene id: 8355:chst2.S
uniprot id: A0A1L8G4H0
uniprot id: A0A974CSV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

8355:c2orf68.L
gene id: 8355:c2orf68.L
uniprot id: A0A974DFI1
uniprot id: Q4V817
names: Similarity
messages: Belongs to the UPF0561 family.

8355:camlg.L
gene id: 8355:camlg.L
uniprot id: A0A1L8GWV0
uniprot id: A0A974HRY1
uniprot id: Q8AVP2
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells.

8355:itga5.L
gene id: 8355:itga5.L
uniprot id: Q06274
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the integrin alpha chain family.
messages: Cell membrane
messages: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1.
messages: Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1 (By similarity). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (By similarity).
messages: focal adhesion

8355:pals1.L
gene id: 8355:pals1.L
uniprot id: Q4KLW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: tight junction

8355:dnal4.S
gene id: 8355:dnal4.S
uniprot id: A0A974HM41
uniprot id: Q68FC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

8355:nbr1.S
gene id: 8355:nbr1.S
uniprot id: A0A1L8EMC4
uniprot id: A0A8J0TS70
uniprot id: A0A8J0TZI9
uniprot id: A0A8J0TZJ6
uniprot id: A0A8J0U0Q4
uniprot id: A0A8J1LZ26
names: Subcellular Location Annotation
messages: autophagosome

8355:LOC121393925
gene id: 8355:LOC121393925
uniprot id: A0A8J1KSH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC9 family.
messages: flagellum
messages: flagellum axoneme

8355:srp9.S
gene id: 8355:srp9.S
uniprot id: A0A1L8G171
uniprot id: A0A974CQT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm

8355:atp8b1.S
gene id: 8355:atp8b1.S
uniprot id: A0A1L8HRW0
uniprot id: A0A8J0UDQ3
uniprot id: A0A974I2C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

8355:id2.L
gene id: 8355:id2.L
uniprot id: Q9PWJ5
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed both maternally and zygotically. Maternal expression declines during cleavage and blastula stages with zygotic expression increasing from gastrulation. From neurula stage onwards, expression levels are relatively constant.
messages: Heterodimer with other HLH proteins.
messages: In the embryo, expressed in a range of tissues, with primary expression in the developing pronephros; expressed in the pronephric anlage, and by the swimming tadpole stages expressed robustly in the pronephric tubules and weakly in the pronephric duct. Expressed in the secondary heart field. In the developing nervous system, expressed in the neural crest and in the neural folds during neurula stages, and at stage 20 in the neural tube, ventral mesoderm and mid-hindbrain boundary. By early tailbud stages, expressed in the neural tube, somites and branchial arches. In tadpoles (stage 37/38), expressed in the heart, eye, otic vesicle, somites and branchial arches. Also expressed in migrating muscle cells. Expressed at a low level in limbs, with expression decreasing as limbs develop, but expressed at a high level in blastemas (regenerated limbs), where expression is localized primarily to the blastemal epidermis. Widely expressed in adults with highest expression in the spleen, skin, intestine and brain, and at a much lower level in testis and heart.
messages: May be induced by Notch signaling.
messages: Nucleus
messages: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Inhibits the activity of both neurogenic (neurod1/neuroD) and myogenic (myod1/myoD) bHLH factors. May play a role in the regulation of the circadian clock.

8355:tmtc4.L
gene id: 8355:tmtc4.L
uniprot id: A0A1L8HH43
uniprot id: A0A974DPA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

8355:LOC121394115
gene id: 8355:LOC121394115
uniprot id: A0A8J1KRY4
names: Similarity
messages: Belongs to the cyclin family.

8355:LOC108702375
gene id: 8355:LOC108702375
uniprot id: A0A8J0TR45
names: Subcellular Location Annotation
messages: Cytoplasm

8355:mthfr.S
gene id: 8355:mthfr.S
uniprot id: A0A1L8FFK7
uniprot id: A0A8J0TCD3
uniprot id: A0A974CBW7
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

8355:sanbr.L
gene id: 8355:sanbr.L
uniprot id: Q08AX9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the KIAA1841 family.
messages: Homodimer.
messages: Negatively regulates class switch recombination or isotype switching in splenic B-cells.
messages: The BTB domain is important for homodimerization and for its function in negative regulation of class switch recombination.

8355:sumf1.L
gene id: 8355:sumf1.L
uniprot id: A0A1L8GPM5
uniprot id: A0A974D7G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

8355:LOC108704650
gene id: 8355:LOC108704650
uniprot id: A0A8J1KWE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

8355:atg16l1.S
gene id: 8355:atg16l1.S
uniprot id: A0A8J0V9Z6
uniprot id: A0A8J0VCU7
uniprot id: A0A8J0VDA2
uniprot id: A0A8J0VE32
uniprot id: A0A8J0VIG3
uniprot id: A0A8J1KR26
uniprot id: A4IFX6
names: Similarity
messages: Belongs to the WD repeat ATG16 family.

8355:LOC108714726
gene id: 8355:LOC108714726
uniprot id: A0A1L8GQ71
uniprot id: A0A974HQ85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

8355:LOC108700377
gene id: 8355:LOC108700377
uniprot id: A0A8J0TQM2
names: Similarity
messages: Belongs to the HARBI1 family.

8355:atp2c2.S
gene id: 8355:atp2c2.S
uniprot id: A0A1L8GEV0
uniprot id: A0A8J0V437
uniprot id: A0A974CZS8
uniprot id: Q1W9P0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:XB5856184.L
gene id: 8355:XB5856184.L
uniprot id: A0A1L8FBP2
uniprot id: A0A974H8T5
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:fam13b.L
gene id: 8355:fam13b.L
uniprot id: A0A1L8GXE5
uniprot id: A0A974DD33
names: Similarity
messages: Belongs to the FAM13 family.

8355:LOC108697923
gene id: 8355:LOC108697923
uniprot id: A0A1L8FEF6
uniprot id: A0A974H9X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

8355:tspan16.S
gene id: 8355:tspan16.S
uniprot id: Q6P420
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8355:LOC108714206
gene id: 8355:LOC108714206
uniprot id: A0A1L8GLS5
uniprot id: A0A8J1MWP8
uniprot id: A0A8J1MYD4
uniprot id: A0A974D476
names: Similarity
messages: Belongs to the AccD/PCCB family.

8355:ywhag.S
gene id: 8355:ywhag.S
uniprot id: A0A8J0UA37
uniprot id: A0A974DKC3
uniprot id: Q6NRY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
messages: Belongs to the 14-3-3 family.
messages: Cytoplasm
messages: Homodimer, and heterodimer with other family members.

8355:aldh6a1.L
gene id: 8355:aldh6a1.L
uniprot id: Q2VPL8
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

8355:e2f7.S
gene id: 8355:e2f7.S
uniprot id: A0A1L8GUD6
uniprot id: A0A8J0UWM1
uniprot id: A0A8J1MRY5
uniprot id: A0A8J1MSU0
uniprot id: A0A8J1MT54
uniprot id: A0A974DB69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

8355:otud5.L
gene id: 8355:otud5.L
uniprot id: Q640H3
names: Function
names: Similarity
messages: Belongs to the peptidase C85 family.
messages: Deubiquitinating enzyme that may function as negative regulator of the innate immune system. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (By similarity).

8355:myadm.S
gene id: 8355:myadm.S
uniprot id: A0A8J0TDF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL family.
messages: Membrane

8355:LOC121402275
gene id: 8355:LOC121402275
uniprot id: A0A8J1MSM0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:birc2.L
gene id: 8355:birc2.L
uniprot id: A0A1L8HJ69
uniprot id: A0A8J0UC89
uniprot id: A0A974DSM5
uniprot id: Q6DDY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Nucleus

8355:lcorl.S
gene id: 8355:lcorl.S
uniprot id: A0A8J0U878
names: Subcellular Location Annotation
messages: Nucleus

8355:rnf126.S
gene id: 8355:rnf126.S
uniprot id: Q6IRP0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates. Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome.
messages: Nucleus

8355:septin9.L
gene id: 8355:septin9.L
uniprot id: A0A1L8EUK6
uniprot id: A0A8J0TU26
uniprot id: A0A8J0TV69
uniprot id: A0A8J0TWG1
uniprot id: A0A8J1LUW4
uniprot id: A0A974BYG2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

8355:LOC108699680
gene id: 8355:LOC108699680
uniprot id: A0A1L8HUM8
uniprot id: A0A974I399
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

8355:pllp.L
gene id: 8355:pllp.L
uniprot id: A0A1L8GLD8
uniprot id: A0A974HNH6
names: Subcellular Location Annotation
messages: Membrane

8355:nrg4.L
gene id: 8355:nrg4.L
uniprot id: A0A1L8GZS6
uniprot id: A0A974DC32
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108702639
gene id: 8355:LOC108702639
uniprot id: A0A1L8ELP2
uniprot id: A0A974H0R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

8355:neurod2.L
gene id: 8355:neurod2.L
uniprot id: A0A1L8ERW7
uniprot id: A0A974H276
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108707439
gene id: 8355:LOC108707439
uniprot id: A0A8J1M7H5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:gpr1.L
gene id: 8355:gpr1.L
uniprot id: A0A1L8EX37
uniprot id: A0A974BZQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

8355:psmb5.S
gene id: 8355:psmb5.S
uniprot id: A0A1L8HPN0
uniprot id: A0A974I1S2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

8355:gclm.L
gene id: 8355:gclm.L
uniprot id: A0A8J0UYX0
uniprot id: Q7ZXV1
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.
messages: Heterodimer of a catalytic heavy chain and a regulatory light chain.

8355:wasf2.S
gene id: 8355:wasf2.S
uniprot id: A0A1L8H7H5
uniprot id: A0A974DJ05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

8355:foxo3.L
gene id: 8355:foxo3.L
uniprot id: A0A8J0V937
uniprot id: Q6EUW1
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Dephosphorylation may promote translocation to the nucleus where the protein induces transcription of target genes and triggers apoptosis.
messages: Expressed both maternally and zygotically. Maternal expression decreases during early cleavage stages becoming absent during gastrulation (PubMed:15567714). Zygotic expression begins during neurulation and expression levels decrease rapidly through the early tadpole stages before becoming enhanced again up till stage 39 (PubMed:15567714).
messages: Localized to the animal hemisphere during early cleavage stages. At the late neurula, localized in the anterior neural plate, neural crest cells and in the hatching gland (PubMed:15567714). As development progresses, expression becomes less localized, being observed in a variety of organs and tissues including the head, branchial arches and somites by stage 32 (PubMed:15567714).
messages: Nucleus
messages: Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy. Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (By similarity). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of sox9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation (By similarity).
messages: cytosol

8355:LOC100037040
gene id: 8355:LOC100037040
uniprot id: A0A1L8GPC0
uniprot id: A0A8J0V7K8
uniprot id: A0A974HPZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTA family.
messages: Membrane

8355:tmem178b.S
gene id: 8355:tmem178b.S
uniprot id: A0A8J0UYU6
names: Similarity
messages: Belongs to the TMEM178 family.

8355:capn5.S
gene id: 8355:capn5.S
uniprot id: A0A1L8HB59
uniprot id: Q6NU10
names: Similarity
messages: Belongs to the peptidase C2 family.

8355:jak1.S
gene id: 8355:jak1.S
uniprot id: Q6DDJ0
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

8355:LOC108706143
gene id: 8355:LOC108706143
uniprot id: A0A1L8HMI3
uniprot id: A0A974I134
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Homodimer.
messages: Secreted

8355:LOC108700455
gene id: 8355:LOC108700455
uniprot id: A0A1L8F4T7
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

8355:ackr3.S
gene id: 8355:ackr3.S
uniprot id: A0A1L8EPQ5
uniprot id: A0A974H1C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:actn4.S
gene id: 8355:actn4.S
uniprot id: A0A8J0TMM8
uniprot id: A0A8J1LLS3
uniprot id: A0A8J1LN98
uniprot id: Q6DCS8
names: Similarity
messages: Belongs to the alpha-actinin family.

8355:magoh.S
gene id: 8355:magoh.S
uniprot id: A0A1L8GG67
uniprot id: A0A974HM76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

8355:cnr2.S
gene id: 8355:cnr2.S
uniprot id: A0A8J1MDT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:ifitm3.L
gene id: 8355:ifitm3.L
uniprot id: Q7SYS1
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8355:xylt2.L
gene id: 8355:xylt2.L
uniprot id: A0A1L8EUE4
uniprot id: A0A8J0TWA0
uniprot id: A0A974H3G0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 14 family. XylT subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: Monomer.

8355:LOC121395512
gene id: 8355:LOC121395512
uniprot id: A0A8J1L7U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

8355:LOC108712901
gene id: 8355:LOC108712901
uniprot id: A0A1L8GSV7
uniprot id: A0A974D906
names: Similarity
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

8355:fam162b.L
gene id: 8355:fam162b.L
uniprot id: A0A1L8G8Z8
uniprot id: A0A974CXA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

8355:tm2d2.S
gene id: 8355:tm2d2.S
uniprot id: A0A1L8GRP5
uniprot id: A0A974D8U7
names: Subcellular Location Annotation
messages: Membrane

8355:cnr2.L
gene id: 8355:cnr2.L
uniprot id: A0A1L8HE40
uniprot id: A0A974DLT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:ak8.L
gene id: 8355:ak8.L
uniprot id: A0A8J1LG97
uniprot id: A0A8J1LH95
uniprot id: Q5M7G4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family.
messages: Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.
messages: cytosol

8355:vps33a.L
gene id: 8355:vps33a.L
uniprot id: A0A974I5R6
uniprot id: B2GTX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

8355:MGC131138
gene id: 8355:MGC131138
uniprot id: A0A8J0V4V1
uniprot id: Q2VPM1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:LOC108700079
gene id: 8355:LOC108700079
uniprot id: A0A1L8F2J3
uniprot id: A0A8J0TGR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:htr7.S
gene id: 8355:htr7.S
uniprot id: A0A1L8FEU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:itih2.L
gene id: 8355:itih2.L
uniprot id: A0A1L8GZH4
uniprot id: A0A974DC81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

8355:tsen34.L
gene id: 8355:tsen34.L
uniprot id: A0A1L8FNM0
uniprot id: A0A8J0TCF6
uniprot id: A0A8J1L7R4
uniprot id: A0A974CHE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

8355:LOC108718769
gene id: 8355:LOC108718769
uniprot id: A0A1L8FYM6
names: Similarity
messages: Belongs to the Speedy/Ringo family.

8355:plcb4.L
gene id: 8355:plcb4.L
uniprot id: A0A1L8G5S6
uniprot id: A0A8J1KM03
uniprot id: A0A8J1KM14
uniprot id: A0A8J1KNR1
uniprot id: A0A974HIP4
names: Cofactor
names: Function
messages: Binds 1 Ca(2+) ion per subunit.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

8355:rnf146.S
gene id: 8355:rnf146.S
uniprot id: A0A8J0TXU6
uniprot id: Q6GQD5
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated proteins. Neuroprotective protein. Protects against cell death induced by DNA damaging agents and rescues cells from G1 arrest. Promotes cell survival after gamma-irradiation. Facilitates DNA repair.
messages: Nucleus
messages: The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
messages: Ubiquitinated; autoubiquitinated.
messages: cytosol

8355:apov1.2.L
gene id: 8355:apov1.2.L
uniprot id: A0A8J0U4H1
names: Function
names: Similarity
messages: Belongs to the apovitellenin family.
messages: Protein component of the very low density lipoprotein (VLDL) of egg-laying females. Potent lipoprotein lipase inhibitor, preventing the loss of triglycerides from VLDL on their way from the liver to the growing oocytes.

8355:mvp.S
gene id: 8355:mvp.S
uniprot id: A0A8J1LWL1
names: Subcellular Location Annotation
messages: Cytoplasm

8355:taok1.S
gene id: 8355:taok1.S
uniprot id: Q7ZYJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: Serine/threonine-protein kinase involved in various processes such as p38/mapk14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of upstream MAP kinase kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade (By similarity).

8355:n4bp3.S
gene id: 8355:n4bp3.S
uniprot id: A0A1L8GUX5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N4BP3 family.
messages: Cytoplasmic vesicle
messages: Detected from early embryogenesis onwards (stages 11-35) (PubMed:24044555, PubMed:28104388). Expressed in the mesoderm during gastrulation (PubMed:24044555). Expressed in migrating neural crest cells, where it partially colocalizes with twist1 (PubMed:28104388). As development proceeds, shows marked expression in developing anterior structures including brain, pharyngeal arches, eye (including retina and lens), otic vesicle, heart, pronephros, liver and cranial ganglia (PubMed:24044555, PubMed:28104388).
messages: Morpholino knockdown severely impairs cranial nerve development, with shorter or missing cranial ganglia and reduced nerve arborization (PubMed:24044555). Neural crest migration is impaired, although neural crest induction is not significantly affected (PubMed:28104388). Brain size is reduced and cranial cartilage development is severely disrupted, leading to smaller head size (PubMed:28104388). Eyes are smaller and deformed, with coloboma formation and disrupted retinal lamination (PubMed:28104388). In eye, expression of the genes rax, pax6 and otx2 is reduced (PubMed:28104388). In brain, expression of the genes emx1, pax6, otx2, en2 and egr2 is reduced (PubMed:28104388). Tissues show increased apoptosis and reduced cell proliferation (PubMed:28104388).
messages: Plays a role in axon and dendrite arborization during cranial nerve development (PubMed:24044555). Also important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (PubMed:28104388).
messages: axon
messages: dendrite

8355:LOC108716811
gene id: 8355:LOC108716811
uniprot id: A0A1L8G984
names: Similarity
messages: Belongs to the sulfatase family.

8355:itga2.L
gene id: 8355:itga2.L
uniprot id: A0A1L8I2E2
uniprot id: A0A974I658
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

8355:polr1f.L
gene id: 8355:polr1f.L
uniprot id: A0A1L8FVY7
uniprot id: A0A974HF78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA43 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

8355:XB22062350.L
gene id: 8355:XB22062350.L
uniprot id: A0A1L8G0F4
uniprot id: A0A974CS03
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

8355:anapc16.L
gene id: 8355:anapc16.L
uniprot id: A0A1L8FJU3
uniprot id: A0A974HBL7
uniprot id: Q6GQ63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APC16 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Cytoplasm
messages: Nucleus
messages: The APC/C is composed of at least 12 subunits. ANAPC16 associates with the rest of the complex independently of ANAPC2 and ANAPC11 (By similarity).
messages: kinetochore

8355:wrn.L
gene id: 8355:wrn.L
uniprot id: A0A1L8HWA9
uniprot id: A0A8J1L8Y1
uniprot id: A0A8J1L8Y6
uniprot id: A0A8J1LAL4
uniprot id: A0A974I3K8
uniprot id: O93530
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Binds 2 magnesium ions per subunit. Has high activity with manganese and zinc ions (in vitro).
messages: Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity).
messages: Nucleus

8355:LOC108702441
gene id: 8355:LOC108702441
uniprot id: A0A1L8ER92
uniprot id: A0A974H1Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8355:ccdc65.S
gene id: 8355:ccdc65.S
uniprot id: A0A1L8H9I0
uniprot id: A0A974DIS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC1 family.
messages: cilium axoneme
messages: flagellum axoneme

8355:pik3c2a.L
gene id: 8355:pik3c2a.L
uniprot id: A0A1L8GIB5
uniprot id: A0A974D1V6
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

8355:LOC108711383
gene id: 8355:LOC108711383
uniprot id: A0A1L8HVV0
uniprot id: A0A8J1N041
uniprot id: A0A8J1N0T4
uniprot id: A0A8J1N0T8
uniprot id: A0A8J1N1K5
uniprot id: A0A974DYI2
names: Subcellular Location Annotation
messages: Membrane

8355:glrb.L
gene id: 8355:glrb.L
uniprot id: A0A1L8HUE6
uniprot id: A0A974DXN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

8355:nr2f6.L
gene id: 8355:nr2f6.L
uniprot id: A0A974DZ43
uniprot id: Q7T0T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

8355:adcyap1r1.S
gene id: 8355:adcyap1r1.S
uniprot id: A0A8J1L0B4
uniprot id: A0A8J1L0B5
uniprot id: A0A8J1L0C3
uniprot id: Q9PTK1
names: Subcellular Location Annotation
messages: Membrane

8355:hsbp1.L
gene id: 8355:hsbp1.L
uniprot id: A0A8J0USB3
uniprot id: A4FVE5
names: Similarity
messages: Belongs to the HSBP1 family.

8355:med1
gene id: 8355:med1
uniprot id: A0A8J0TJB8
uniprot id: A0A974BWK9
uniprot id: Q6INP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8355:adamts10.L
gene id: 8355:adamts10.L
uniprot id: A0A1L8HWU6
uniprot id: A0A8J0UWB6
uniprot id: A0A8J0UZV4
uniprot id: A0A8J1KL01
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8355:tmem35a.L
gene id: 8355:tmem35a.L
uniprot id: A0A1L8F6S3
uniprot id: A0A974C6A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

8355:bap1.L
gene id: 8355:bap1.L
uniprot id: A0A1L8GPB2
uniprot id: A0A974D7T4
names: Similarity
messages: Belongs to the peptidase C12 family.

8355:LOC121397317
gene id: 8355:LOC121397317
uniprot id: A0A8J1LK33
names: Subcellular Location Annotation
messages: Membrane

8355:fam53a.L
gene id: 8355:fam53a.L
uniprot id: A0A1L8HT13
uniprot id: A0A974DXB5
names: Similarity
messages: Belongs to the FAM53 family.

8355:b4galnt1.L
gene id: 8355:b4galnt1.L
uniprot id: A0A8J1M4Z6
uniprot id: Q7ZX76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:capn11.L
gene id: 8355:capn11.L
uniprot id: A0A974HIZ9
uniprot id: Q6PAF2
names: Similarity
messages: Belongs to the peptidase C2 family.

8355:pparg.S
gene id: 8355:pparg.S
uniprot id: A0A8J1KKI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Heterodimer with other nuclear receptors.
messages: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.
messages: Nucleus

8355:map3k10.L
gene id: 8355:map3k10.L
uniprot id: A0A1L8F8T6
uniprot id: A0A974C8M7
uniprot id: Q7T2V3
names: Activity Regulation
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Activates the JUN N-terminal pathway. Essential for pronephros and cement gland development.
messages: Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Expressed zygotically from stages 12 to 14 (late gastrula to early neurula), increasing in concentration up to stages 40 to 45 (late tadpole). Expression continues through to adults.
messages: Homodimer.
messages: Homodimer. Binds to the GTPase rac1 but not cdc42 or rhoA. Interacts (via kinase domain) with pak1 (via kinase domain). Interacts with the ubiquitin-conjugating enzyme ube2d4.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.
messages: In adults, strongly expressed in the brain and spleen with lower levels in pancreas, heart, muscle and kidney (at protein level). In the developing embryo, expressed at stage 22 in the cement gland. Weakly expressed in the pronephros from stage 24 or 25, with expression increasing in strength by stage 30 and continuing at least until stage 37. Expression in the developing pronephros correlates with epithelialization of the proximal pronephric tubules.
messages: Mono- and poly-ubiquitinated.

8355:crygbl.1.L
gene id: 8355:crygbl.1.L
uniprot id: Q66KW2
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:ttyh2.S
gene id: 8355:ttyh2.S
uniprot id: A0A8J1LVM9
uniprot id: A0A8J1LVQ2
uniprot id: A0A974BT99
uniprot id: Q7ZWN9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probable chloride channel.
messages: Probable large-conductance Ca(2+)-activated chloride channel.

8355:tmem184a.L
gene id: 8355:tmem184a.L
uniprot id: A0A1L8EXX6
uniprot id: A0A974C049
names: Subcellular Location Annotation
messages: Membrane

8355:urah.L
gene id: 8355:urah.L
uniprot id: A0A310TNV3
uniprot id: A0A8J0U7B3
uniprot id: A0A8J0U9J8
uniprot id: A0A8J1MUG0
uniprot id: A0A974BR70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transthyretin family.
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Homotetramer.
messages: Secreted
messages: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

8355:osbp.L
gene id: 8355:osbp.L
uniprot id: A0A8J0T1K1
names: Similarity
messages: Belongs to the OSBP family.

8355:cipc.S
gene id: 8355:cipc.S
uniprot id: Q6NRH7
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional repressor which acts as a negative-feedback regulator of CLOCK-BMAL1 transcriptional activity in the circadian-clock mechanism. The physiogical relevance of these observations is unsure.
messages: cytosol

8355:cc2d1b.L
gene id: 8355:cc2d1b.L
uniprot id: A0A8J1MUD8
uniprot id: A0A8J1MUQ3
uniprot id: A0A974D6B9
uniprot id: Q6PF54
names: Similarity
messages: Belongs to the CC2D1 family.

8355:hoxa5.L
gene id: 8355:hoxa5.L
uniprot id: A0A1L8FW27
uniprot id: A0A974CMA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

8355:cap1.L
gene id: 8355:cap1.L
uniprot id: A0A974DN04
uniprot id: Q6DE60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane

8355:krt60.L
gene id: 8355:krt60.L
uniprot id: A0A8J1MA00
names: Similarity
messages: Belongs to the intermediate filament family.

8355:psmd13.S
gene id: 8355:psmd13.S
uniprot id: Q66IX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S11 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

8355:rflb.S
gene id: 8355:rflb.S
uniprot id: A0A310TNT8
uniprot id: A0A974BQZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

8355:tipin.L
gene id: 8355:tipin.L
uniprot id: A0A1L8H168
uniprot id: A0A974DDM4
uniprot id: Q0IHI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSM3 family.
messages: Cytoplasm
messages: Interacts with timeless, which impairs timeless self-association.
messages: Nucleus
messages: Plays an important role in the control of DNA replication and the maintenance of replication fork stability.
messages: Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be required for the replication checkpoint induced by hydroxyurea or ultraviolet light (By similarity).

8355:LOC121402012
gene id: 8355:LOC121402012
uniprot id: A0A8J1MQW7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:clcn2.S
gene id: 8355:clcn2.S
uniprot id: A0A1L8G3M5
uniprot id: A0A8J1KTN4
uniprot id: A0A974CS61
names: Subcellular Location Annotation
messages: Membrane

8355:hs3st3a1.S
gene id: 8355:hs3st3a1.S
uniprot id: A0A1L8EN44
uniprot id: A0A974BTR4
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8355:vwc2l.S
gene id: 8355:vwc2l.S
uniprot id: A0A1L8EPK8
uniprot id: A0A8J1LX56
uniprot id: A0A974H1G2
names: Subcellular Location Annotation
messages: Synapse

8355:fbp2.L
gene id: 8355:fbp2.L
uniprot id: A0A974I4P7
uniprot id: Q66IR7
names: Similarity
messages: Belongs to the FBPase class 1 family.

8355:amigo2.L
gene id: 8355:amigo2.L
uniprot id: A0A1L8GYN4
uniprot id: A0A974HSR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. AMIGO family.
messages: Membrane

8355:serbp1.S
gene id: 8355:serbp1.S
uniprot id: A0A8J0V466
uniprot id: A0A974HM18
uniprot id: Q7ZWZ2
names: Similarity
messages: Belongs to the SERBP1-HABP4 family.

8355:plppr2.L
gene id: 8355:plppr2.L
uniprot id: A0A1L8H2Z4
uniprot id: A0A8J0ULF7
uniprot id: A0A8J0USB5
uniprot id: A0A8J0UTK3
uniprot id: A0A8J1MP59
uniprot id: A0A8J1MQ89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

8355:LOC108713270
gene id: 8355:LOC108713270
uniprot id: A0A1L8GV89
uniprot id: A0A974HRV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

8355:mrpl47.L
gene id: 8355:mrpl47.L
uniprot id: A0A8J0VD10
uniprot id: A0A8J0VHB1
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

8355:MGC83206
gene id: 8355:MGC83206
uniprot id: A0A8J1MQ58
uniprot id: Q6INE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

8355:cnot1.L
gene id: 8355:cnot1.L
uniprot id: A0A1L8GLF8
uniprot id: A0A8J0V1J0
uniprot id: A0A974HP30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT1 family.
messages: Nucleus

8355:mex3b.S
gene id: 8355:mex3b.S
uniprot id: A1L3F4
uniprot id: C5NSX3
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Binds RNA through its KH domains.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Nucleus
messages: P-body
messages: RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms (By similarity).

8355:LOC108719910
gene id: 8355:LOC108719910
uniprot id: A0A1L8FR33
uniprot id: A0A8J0VJM3
uniprot id: A0A974CJZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.

8355:LOC108712621
gene id: 8355:LOC108712621
uniprot id: A0A1L8GR53
uniprot id: A0A8J0UNW3
uniprot id: A0A8J0UUI1
uniprot id: A0A8J0UVQ0
uniprot id: A0A8J0UVQ4
uniprot id: A0A8J0UZ46
uniprot id: A0A8J0UZ53
uniprot id: A0A8J1MQ76
uniprot id: A0A8J1MQD3
uniprot id: A0A8J1MR83
uniprot id: A0A8J1MSF2
uniprot id: A0A974D8X0
names: Similarity
messages: Belongs to the RAPGEF2 family.

8355:LOC108708347
gene id: 8355:LOC108708347
uniprot id: A0A8J0UE78
names: Similarity
messages: Belongs to the dynein heavy chain family.

8355:psmb3.L
gene id: 8355:psmb3.L
uniprot id: A0A974BW66
uniprot id: Q5M999
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

8355:LOC108708432
gene id: 8355:LOC108708432
uniprot id: A0A8J0UEJ5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8355:polr2d.L
gene id: 8355:polr2d.L
uniprot id: A0A974HKK7
uniprot id: Q66KV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Nucleus

8355:fam189a2.L
gene id: 8355:fam189a2.L
uniprot id: A0A1L8HYK5
uniprot id: A0A8J1KTQ1
uniprot id: A0A974I4H7
names: Similarity
messages: Belongs to the ENTREP family.

8355:LOC108709933
gene id: 8355:LOC108709933
uniprot id: A0A1L8HAE6
uniprot id: A0A974DJR4
names: Subcellular Location Annotation
messages: Membrane

8355:gdi1.S
gene id: 8355:gdi1.S
uniprot id: A0A974H536
uniprot id: Q642Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

8355:endog.L
gene id: 8355:endog.L
uniprot id: A0A1L8F798
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

8355:LOC121394834
gene id: 8355:LOC121394834
uniprot id: A0A8J1L047
uniprot id: A0A8J1L050
uniprot id: A0A8J1L054
uniprot id: A0A8J1L1P3
uniprot id: A0A8J1L2Y6
names: Subcellular Location Annotation
messages: Nucleus

8355:rpl6.L
gene id: 8355:rpl6.L
uniprot id: A0A1L8I1W4
uniprot id: A0A974I4W1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

8355:lsm4.L
gene id: 8355:lsm4.L
uniprot id: A0A1L8HWU0
uniprot id: A0A8J0UX21
uniprot id: A0A8J0UX26
uniprot id: A0A8J0V0N1
uniprot id: A0A974DYR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

8355:mfsd4a.S
gene id: 8355:mfsd4a.S
uniprot id: A0A1L8H741
uniprot id: A0A974DI78
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108697209
gene id: 8355:LOC108697209
uniprot id: A0A8J1LDB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

8355:LOC121399163
gene id: 8355:LOC121399163
uniprot id: A0A8J1LZZ8
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:LOC108717481
gene id: 8355:LOC108717481
uniprot id: A0A1L8G505
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

8355:dbt.S
gene id: 8355:dbt.S
uniprot id: A0A1L8GGF6
uniprot id: A0A974CZI2
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

8355:suz12
gene id: 8355:suz12
uniprot id: A0A8J0TYF8
uniprot id: A0A974H196
uniprot id: C6GGW6
names: Similarity
messages: Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.

8355:LOC108695919
gene id: 8355:LOC108695919
uniprot id: A0A8J1L7R1
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8355:ap2s1.S
gene id: 8355:ap2s1.S
uniprot id: A0A974H7H1
uniprot id: Q66L27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cell membrane
messages: coated pit

8355:ablim3.L
gene id: 8355:ablim3.L
uniprot id: A0A1L8GXM1
uniprot id: A0A1L8GXR8
uniprot id: A0A8J0UP36
uniprot id: A0A8J0UQC2
uniprot id: A0A8J0UQC9
uniprot id: A0A8J1MK43
uniprot id: A0A8J1MK64
uniprot id: A0A8J1MKY0
uniprot id: A0A8J1MM54
names: Subcellular Location Annotation
messages: Cytoplasm

8355:nceh1.L
gene id: 8355:nceh1.L
uniprot id: A0A1L8GA66
uniprot id: A0A974HJS3
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

8355:rps27.S
gene id: 8355:rps27.S
uniprot id: A0A974C517
uniprot id: P47904
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for proper rRNA processing and maturation of 18S rRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: Cytoplasm
messages: nucleolus

8355:dynlt5.L
gene id: 8355:dynlt5.L
uniprot id: A0A1L8GLV0
uniprot id: A0A974D392
uniprot id: Q3B8D7
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

8355:rpa1.S
gene id: 8355:rpa1.S
uniprot id: A0A8J1MD24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: PML body

8355:rrad.L
gene id: 8355:rrad.L
uniprot id: Q6GLV8
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

8355:smg8.L
gene id: 8355:smg8.L
uniprot id: A0A1L8HG19
uniprot id: A0A974DN67
names: Function
names: Similarity
messages: Belongs to the SMG8 family.
messages: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

8355:grk4.S
gene id: 8355:grk4.S
uniprot id: Q5XH04
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

8355:LOC108700221
gene id: 8355:LOC108700221
uniprot id: A0A8J0TNX5
uniprot id: A0A8J0TS27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS3 family.
messages: spindle

8355:LOC108709044
gene id: 8355:LOC108709044
uniprot id: A0A1L8HBC3
uniprot id: A0A974DK15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:sfmbt1.S
gene id: 8355:sfmbt1.S
uniprot id: A0A1L8GH75
uniprot id: A0A974HMD4
names: Subcellular Location Annotation
messages: Nucleus

8355:parp1.L
gene id: 8355:parp1.L
uniprot id: A0A974CVF0
uniprot id: Q2NLA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Chromosome
messages: Nucleus
messages: Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair.

8355:syn1.L
gene id: 8355:syn1.L
uniprot id: A0A8J1LF70
uniprot id: A0A8J1LGN2
uniprot id: A0A8J1LHP5
names: Similarity
messages: Belongs to the synapsin family.

8355:tgs1.L
gene id: 8355:tgs1.L
uniprot id: A0A8J0VIK6
uniprot id: Q6GPD4
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

8355:LOC108697427
gene id: 8355:LOC108697427
uniprot id: A0A8J0TBW6
uniprot id: A0A8J1LE08
names: Subcellular Location Annotation
messages: Nucleus

8355:xkr7.L
gene id: 8355:xkr7.L
uniprot id: A0A1L8ETD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

8355:ypel5.S
gene id: 8355:ypel5.S
uniprot id: A0A974CQ06
uniprot id: Q6DEA6
names: Similarity
messages: Belongs to the yippee family.

8355:ventx1.2.L
gene id: 8355:ventx1.2.L
uniprot id: A0A1L8FJ88
uniprot id: A0A974CEA5
names: Subcellular Location Annotation
messages: Nucleus

8355:tmem145.L
gene id: 8355:tmem145.L
uniprot id: A0A8J0T6F6
uniprot id: A0A974CHU5
uniprot id: Q5U239
names: Subcellular Location Annotation
messages: Membrane

8355:hexd.L
gene id: 8355:hexd.L
uniprot id: A0A1L8EUL2
uniprot id: A0A8J0TRE6
uniprot id: A0A8J0TTB9
uniprot id: A0A974H2Z2
uniprot id: Q6DDT7
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

8355:cdipt.L
gene id: 8355:cdipt.L
uniprot id: Q6INH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

8355:crygdl.14.S
gene id: 8355:crygdl.14.S
uniprot id: A0A1L8HNL5
uniprot id: A0A974DT86
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:LOC108717561
gene id: 8355:LOC108717561
uniprot id: A0A8J1KWF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8355:LOC108702330
gene id: 8355:LOC108702330
uniprot id: A0A8J0TYA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8355:zdhhc6.S
gene id: 8355:zdhhc6.S
uniprot id: Q6DD05
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:LOC108698479
gene id: 8355:LOC108698479
uniprot id: A0A8J0TAZ2
names: Subcellular Location Annotation
messages: Membrane

8355:taf9b.L
gene id: 8355:taf9b.L
uniprot id: Q641A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

8355:ppp1r10.L
gene id: 8355:ppp1r10.L
uniprot id: A0A1L8F8L9
uniprot id: A0A974C7G3
names: Subcellular Location Annotation
messages: Nucleus

8355:tbcd.L
gene id: 8355:tbcd.L
uniprot id: A0A1L8EUQ4
uniprot id: A0A974H343
names: Similarity
messages: Belongs to the TBCD family.

8355:rmnd5a.L
gene id: 8355:rmnd5a.L
uniprot id: Q6GLP4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Detected at constant levels throughout embryonic development (at protein level). Detected at high levels at the four cell stage of embryogenesis, followed by a steady decline until gastrulation. Detected at low levels throughout further stages of embryo development. Primarily expressed in the head region during gastrulation, and in the neuroectoderm during neurulation.
messages: E3 ubiquitin-protein ligase component of the CTLH complex.
messages: Identified in the CTLH complex that contains at least RANBP9, MKLN1, MAEA, RMND5A, GID8 and ARMC8.
messages: Morpholino knockdown of the protein disrupts normal development of the mesencephalon, the prosencephalon and the eyes.
messages: nucleoplasm

8355:add1.L
gene id: 8355:add1.L
uniprot id: A0A1L8HTA2
uniprot id: A0A8J0T7B9
uniprot id: A0A8J0T7F9
uniprot id: A0A8J0T7G4
uniprot id: A0A8J0TDD0
uniprot id: A0A8J0TDD5
uniprot id: A0A8J0TFA0
uniprot id: A0A8J0TFB6
uniprot id: A0A8J0TGU1
uniprot id: A0A8J1MP42
uniprot id: A0A8J1MP73
uniprot id: A0A8J1MP99
uniprot id: A0A8J1MPB5
uniprot id: A0A8J1MQ69
uniprot id: A0A8J1MQ78
uniprot id: A0A8J1MQ83
uniprot id: A0A8J1MQB3
uniprot id: A0A8J1MR92
uniprot id: A0A974DYP8
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

8355:LOC108716156
gene id: 8355:LOC108716156
uniprot id: A0A1L8G8Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

8355:esd.S
gene id: 8355:esd.S
uniprot id: A0A1L8H9J8
uniprot id: A0A8J0UAE1
uniprot id: A0A974DKM6
uniprot id: Q66KU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the esterase D family.
messages: Cytoplasmic vesicle
messages: Serine hydrolase involved in the detoxification of formaldehyde.

8355:foxd1.L
gene id: 8355:foxd1.L
uniprot id: Q9PSY4
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in gastrula (stage 10) embryos in the dorsolateral mesoderm, where expression continues until mesoderm involution. In early neurula embryos (stage 12.5), expressed in the anterior neural plate in the prospective diencephalon and eye field, and in the anterior neural folds, with expression becoming stronger as neurulation proceeds. At stage 14, transiently expressed in two stripes lateral to the midline. Expressed in premigratory, but not migratory, cephalic neural crest cells. At stage 20, expressed in the paraxial mesoderm and in the optic vesicle. At stage 21, expression continues in the forebrain and begins in cells lateral to the rostral somites as well as in the neural tissue of the tailbud. By stage 36, detected in restricted regions of the forebrain and in the temporal retina. Caudally, expression continues in the neural tissue of the tailbud. At this stage, there is also strong expression at the caudal (tail) end of the embryo on the ventral side.
messages: Nucleus
messages: Transcriptional repressor that down-regulates bmp4 signaling in both mesoderm and ectoderm. Regulates mesoderm patterning by repressing ventral mesoderm genes and promoting the expression of dorsolateral genes. Can also neuralize ectodermal cells directly. Inhibits neural crest migration. The transcription factors foxd1 and foxg1 mutually repress each other to pattern the forebrain.

8355:hnrnpdl.L
gene id: 8355:hnrnpdl.L
uniprot id: A0A974DYA7
uniprot id: Q7ZX83
names: Function
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Binds DNA and RNA (By similarity).
messages: Cytoplasm
messages: Nucleus

8355:LOC108698627
gene id: 8355:LOC108698627
uniprot id: A0A8J0TL39
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:LOC108717229
gene id: 8355:LOC108717229
uniprot id: A0A8J1KQE5
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:kcnj16.L
gene id: 8355:kcnj16.L
uniprot id: A0A8J1LT81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

8355:meis3.S
gene id: 8355:meis3.S
uniprot id: A0A1L8F3W8
uniprot id: A0A1L8F3Y6
uniprot id: A0A974H671
uniprot id: A0A974H6M4
uniprot id: Q7ZY13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A caudalizing protein which is required to pattern the anterior/posterior (A/P) axis during central nervous system (CNS) formation. Inhibits anterior neural expression and acts as a transcriptional activator to induce posterior neural gene expression. Maintains a proper A/P balance required for hindbrain formation by activating the FGF/MAPK pathway, which modulates the planar cell polarity (PCP) pathway. Interacts with retinoid signaling during hindbrain patterning (By similarity).
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

8355:LOC108710156
gene id: 8355:LOC108710156
uniprot id: A0A8J0UGB8
uniprot id: A0A8J0UMV2
uniprot id: A0A8J1MN50
uniprot id: A0A8J1MP58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

8355:LOC108719897
gene id: 8355:LOC108719897
uniprot id: A0A1L8FQY2
uniprot id: A0A974CIL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

8355:LOC108715125
gene id: 8355:LOC108715125
uniprot id: A0A1L8GD53
uniprot id: A0A974HKS3
names: Similarity
messages: Belongs to the alpha-actinin family.

8355:LOC108700410
gene id: 8355:LOC108700410
uniprot id: A0A1L8F506
uniprot id: A0A974C542
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

8355:nsfl1c.L
gene id: 8355:nsfl1c.L
uniprot id: A0A974BXK4
uniprot id: Q7ZYT4
names: Subcellular Location Annotation
messages: Golgi stack

8355:LOC108710801
gene id: 8355:LOC108710801
uniprot id: A0A1L8GWM2
uniprot id: A0A974HSA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

8355:wnt6.S
gene id: 8355:wnt6.S
uniprot id: A0A974BUE5
uniprot id: B0FK91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8355:LOC108709645
gene id: 8355:LOC108709645
uniprot id: A0A1L8H8H5
uniprot id: A0A974HWA0
names: Similarity
messages: Belongs to the NUPR family.

8355:bmt2.S
gene id: 8355:bmt2.S
uniprot id: A0A974DAS3
uniprot id: Q52KX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BMT2 family.
messages: Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.
messages: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.

8355:hprt1.L
gene id: 8355:hprt1.L
uniprot id: Q6DDP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

8355:LOC108700239
gene id: 8355:LOC108700239
uniprot id: A0A974H7Y3
uniprot id: Q91575
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity).
messages: Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. The precise function of polyglycylation is still unclear.
messages: The MREI motif is common among all beta-tubulin isoforms and may be critical for tubulin autoregulation.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

8355:slc2a4.L
gene id: 8355:slc2a4.L
uniprot id: Q6GPU6
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

8355:eipr1.S
gene id: 8355:eipr1.S
uniprot id: A0A1L8G5E3
uniprot id: A0A974CSM7
uniprot id: A0A974CSU8
uniprot id: Q32NM0
names: Similarity
messages: Belongs to the WD repeat EIPR1 family.

8355:LOC108698272
gene id: 8355:LOC108698272
uniprot id: A0A8J0TIV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: cytoskeleton

8355:LOC108710795
gene id: 8355:LOC108710795
uniprot id: A0A1L8GWL3
uniprot id: A0A974D9Y4
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

8355:nek9.L
gene id: 8355:nek9.L
uniprot id: A0A8J0TEE8
uniprot id: Q6DKD3
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

8355:slc7a9.L
gene id: 8355:slc7a9.L
uniprot id: A0A974HNG1
uniprot id: A9JS28
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108707818
gene id: 8355:LOC108707818
uniprot id: A0A1L8HC05
uniprot id: A0A974HXB3
names: Similarity
messages: Belongs to the cystatin family.

8355:cope.L
gene id: 8355:cope.L
uniprot id: A0A1L8HXP4
uniprot id: A0A974E0J0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPE family.
messages: Cytoplasm
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

8355:zdhhc2.S
gene id: 8355:zdhhc2.S
uniprot id: A0A1L8HLA6
uniprot id: A0A8J0U758
uniprot id: A0A974DRR2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:LOC108699795
gene id: 8355:LOC108699795
uniprot id: A0A1L8F052
uniprot id: A0A974C1Z5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:kif23.S
gene id: 8355:kif23.S
uniprot id: A0A8J0UMW3
uniprot id: A0A8J0UTL4
uniprot id: A0A8J0UTM3
uniprot id: A0A8J0UUQ3
uniprot id: A0A8J0UUT0
uniprot id: A0A8J0UUT9
uniprot id: A0A8J0UY73
uniprot id: A0A8J1MPF9
uniprot id: Q5U4W5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8355:spo11.S
gene id: 8355:spo11.S
uniprot id: A0A8J0TY63
names: Similarity
messages: Belongs to the TOP6A family.

8355:adrm1.L
gene id: 8355:adrm1.L
uniprot id: A0A974BWV5
uniprot id: Q7ZXD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ADRM1 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor.
messages: Cytoplasm
messages: Nucleus

8355:gdpd5.L
gene id: 8355:gdpd5.L
uniprot id: A0A8J1MAM6
uniprot id: A0A8J1MAZ3
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

8355:ccl20.S
gene id: 8355:ccl20.S
uniprot id: A0A1L8G509
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

8355:chrm4.S
gene id: 8355:chrm4.S
uniprot id: A0A1L8GDU2
uniprot id: A0A8J0VA52
uniprot id: A0A8J1KJI9
uniprot id: A0A974D0J2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

8355:arl8b.S
gene id: 8355:arl8b.S
uniprot id: A0A1L8GHJ1
uniprot id: A0A974D0E4
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

8355:LOC108700279
gene id: 8355:LOC108700279
uniprot id: A0A1L8F3Y2
uniprot id: A0A974C4C9
names: Subcellular Location Annotation
messages: Nucleus

8355:manbal.S
gene id: 8355:manbal.S
uniprot id: A0A1L8EMQ8
uniprot id: A0A974H0R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0239 family.
messages: Membrane

8355:lgr4.S
gene id: 8355:lgr4.S
uniprot id: Q32NJ0
names: Subcellular Location Annotation
messages: Membrane

8355:b4galt3l2.S
gene id: 8355:b4galt3l2.S
uniprot id: A0A8J1LAB8
uniprot id: Q6DDG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

8355:ribc1.S
gene id: 8355:ribc1.S
uniprot id: A0A8J1LLY3
uniprot id: Q5PQ36
names: Similarity
messages: Belongs to the RIB43A family.

8355:LOC121400928
gene id: 8355:LOC121400928
uniprot id: A0A8J1MGK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:taf5l.L
gene id: 8355:taf5l.L
uniprot id: A0A974CWE7
uniprot id: Q6DE31
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

8355:hscb.L
gene id: 8355:hscb.L
uniprot id: A0A1L8I061
uniprot id: A0A8J0UBL0
uniprot id: A0A974E240
uniprot id: Q6GM83
names: Similarity
messages: Belongs to the HscB family.

8355:penk.L
gene id: 8355:penk.L
uniprot id: A0A8J0PZX3
uniprot id: Q5XGN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Secreted

8355:LOC108716369
gene id: 8355:LOC108716369
uniprot id: A0A1L8GAX3
uniprot id: A0A974CW51
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:itgb4.S
gene id: 8355:itgb4.S
uniprot id: A0A1L8EMZ9
uniprot id: A0A8J0U114
uniprot id: A0A8J1LXP0
uniprot id: A0A974H171
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

8355:st14.L
gene id: 8355:st14.L
uniprot id: Q6GR54
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:aqp5.S
gene id: 8355:aqp5.S
uniprot id: A0A1L8HA83
uniprot id: A0A974HWU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

8355:tyro3.L
gene id: 8355:tyro3.L
uniprot id: A0A974C8I6
uniprot id: B7ZPY0
uniprot id: Q8QFP9
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
messages: Cell membrane
messages: Detected in brain, spinal cord, intestine, lung, stomach, ovary, testis, skin and eye.
messages: Levels are high at cleavage and blastula stage, and low at gastrulation stage. Subsequently, levels increase from mid-neurulation to the tail bud stage. Detected in embryonic brain at the tail bud stage.
messages: May be involved in cell adhesion processes, particularly in the central nervous system.
messages: Membrane
messages: Tyrosine phosphorylated upon receptor stimulation.

8355:acss2.2.L
gene id: 8355:acss2.2.L
uniprot id: A0A1L8FYI4
uniprot id: A0A974CQP8
uniprot id: Q6GQF6
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

8355:hs2st1.S
gene id: 8355:hs2st1.S
uniprot id: A0A8J0V4W9
uniprot id: A0A974CZF6
uniprot id: Q6NU67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:LOC108708225
gene id: 8355:LOC108708225
uniprot id: A0A1L8HFE3
uniprot id: A0A974DPJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

8355:slc25a36.S
gene id: 8355:slc25a36.S
uniprot id: A0A974HI61
uniprot id: A5PKR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8355:mx1.L
gene id: 8355:mx1.L
uniprot id: A0A1L8HCE3
uniprot id: A0A974DLU1
uniprot id: H2DQ54
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

8355:ykt6.L
gene id: 8355:ykt6.L
uniprot id: A0A1L8H1T5
uniprot id: A0A974DFC2
uniprot id: Q32N70
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Cytoplasmic vesicle membrane
messages: Farnesylation is required for Golgi targeting.
messages: Golgi apparatus membrane
messages: Membrane
messages: Palmitoylated; catalyzes its own palmitoylation. Palmitoylation is required for Golgi targeting.
messages: The longin domain regulates palmitoylation and membrane targeting.
messages: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.
messages: cytosol

8355:LOC108704352
gene id: 8355:LOC108704352
uniprot id: A0A8J0TWL0
names: Similarity
messages: Belongs to the Bcl-2 family.

8355:pou4f4.L
gene id: 8355:pou4f4.L
uniprot id: A0A1L8F7T5
uniprot id: A0A974C6M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

8355:gpkow.L
gene id: 8355:gpkow.L
uniprot id: A0A8J1LI54
uniprot id: A0A8J1LIQ1
uniprot id: A0A8J1LJE0
uniprot id: A0A8J1LKI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOS2 family.
messages: Nucleus
messages: RNA-binding protein involved in pre-mRNA splicing.

8355:hhipl1.S
gene id: 8355:hhipl1.S
uniprot id: A0A1L8F099
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:slc5a12.L
gene id: 8355:slc5a12.L
uniprot id: A0A1L8GJF7
uniprot id: A0A8J0UZM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

8355:LOC108710328
gene id: 8355:LOC108710328
uniprot id: A0A8J0US86
names: Subcellular Location Annotation
messages: Membrane

8355:LOC121401310
gene id: 8355:LOC121401310
uniprot id: A0A8J1MIR9
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:tmcc3.S
gene id: 8355:tmcc3.S
uniprot id: A0A1L8GUQ5
uniprot id: A0A974HRS8
names: Similarity
messages: Belongs to the TEX28 family.

8355:rflnb.S
gene id: 8355:rflnb.S
uniprot id: A1L2S1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Refilin family.
messages: Interacts with FLNA and FLNB.
messages: cytoskeleton

8355:LOC121399621
gene id: 8355:LOC121399621
uniprot id: A0A8J1M701
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:adck5.L
gene id: 8355:adck5.L
uniprot id: A0A1L8G0H3
uniprot id: A0A8J0VIB9
uniprot id: A0A8J0VKQ0
uniprot id: A0A8J0VLU2
uniprot id: A0A8J0VPM6
uniprot id: A0A974HGS6
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

8355:LOC108714603
gene id: 8355:LOC108714603
uniprot id: A0A8J0V3R3
uniprot id: A0A8J1MY42
uniprot id: A0A8J1MZ17
uniprot id: A0A8J1N0D2
names: Similarity
messages: Belongs to the DOCK family.

8355:fut9.S
gene id: 8355:fut9.S
uniprot id: A0A8J0VA12
uniprot id: A0A974HHG7
uniprot id: Q8UWC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

8355:LOC108715472
gene id: 8355:LOC108715472
uniprot id: A0A8J0V229
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:kif19.S
gene id: 8355:kif19.S
uniprot id: A0A974H0K7
uniprot id: Q7ZXX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips.
messages: cilium
messages: cytoskeleton

8355:marcks.L
gene id: 8355:marcks.L
uniprot id: A0A1L8G8S4
uniprot id: A0A974HJJ2
names: Similarity
messages: Belongs to the MARCKS family.

8355:hdx.L
gene id: 8355:hdx.L
uniprot id: A0A1L8F7Q3
uniprot id: A0A8J0TH07
uniprot id: A0A974H7E3
names: Subcellular Location Annotation
messages: Nucleus

8355:them6.L
gene id: 8355:them6.L
uniprot id: Q6NRK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THEM6 family.
messages: Secreted

8355:fmr1.S
gene id: 8355:fmr1.S
uniprot id: A0A974C3K8
uniprot id: Q2KHP9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FMR1 family.
messages: Cell membrane
messages: Chromosome
messages: Cytoplasmic ribonucleoprotein granule
messages: Homodimer. Heterodimer.
messages: Membrane
messages: Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of target mRNAs. Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Binds poly(G) and poly(U), and to a lower extent poly(A) and poly(C) (By similarity).
messages: Nucleus
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Presynaptic cell membrane
messages: Stress granule
messages: Synapse
messages: Synaptic cell membrane
messages: The C-terminal disordered region undergoes liquid-liquid phase separation (LLPS) for the formation of a membraneless compartment that concentrates mRNAs with associated regulatory factors.
messages: axon
messages: centromere
messages: dendrite
messages: dendritic spine
messages: filopodium tip
messages: growth cone
messages: neuron projection
messages: nucleolus
messages: perinuclear region
messages: synaptosome

8355:LOC108698849
gene id: 8355:LOC108698849
uniprot id: A0A1L8F5X2
uniprot id: A0A974C5M0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8355:ccdc43.L
gene id: 8355:ccdc43.L
uniprot id: A0A8J0TSY3
names: Similarity
messages: Belongs to the CCDC43 family.

8355:wee1.L
gene id: 8355:wee1.L
uniprot id: A0A8J1MUX6
uniprot id: Q8AYK6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a zygotic negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed cdk1 before the onset of mitosis by mediating phosphorylation of cdk1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed cdk1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-cdk1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric cdk1 does not occur. Involved in convergent extension of the paraxial mesoderm during neurulation by inhibiting the cell cycle.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Binds 2 magnesium ions per subunit.
messages: Nucleus
messages: Was initially assigned as wee2 (PubMed:12217326). However, it corresponds to the zygotic protein WEE1 in mammals.
messages: Zygotically expressed. Expressed in regions of the embryo that are devoid of mitotic cells, such as the involuting mesoderm.

8355:dnajc5.S
gene id: 8355:dnajc5.S
uniprot id: O42196
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cell membrane
messages: May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings.
messages: Melanosome
messages: Membrane
messages: Palmitoylated. Palmitoylation occurs probably in the cysteine-rich domain and regulates DNAJC5 stable membrane attachment.
messages: chromaffin granule membrane
messages: cytosol

8355:LOC121398121
gene id: 8355:LOC121398121
uniprot id: A0A8J1LT21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8355:dlk1.L
gene id: 8355:dlk1.L
uniprot id: A0A1L8F9X2
uniprot id: A0A8J1LJY2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC121395649
gene id: 8355:LOC121395649
uniprot id: A0A1L8FNZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

8355:sypl2.S
gene id: 8355:sypl2.S
uniprot id: A0A8J0U9P8
uniprot id: A0A8J0UHW5
uniprot id: Q7ZWV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

8355:rpl35.L
gene id: 8355:rpl35.L
uniprot id: A0A8J0T9B1
uniprot id: Q4FZQ7
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

8355:gata3.S
gene id: 8355:gata3.S
uniprot id: A0A8J0UT92
uniprot id: A0A8J0UUF7
uniprot id: A0A8J0UXU0
uniprot id: A0A974DA49
uniprot id: Q2TAR8
names: Subcellular Location Annotation
messages: Nucleus

8355:baiap2.L
gene id: 8355:baiap2.L
uniprot id: A0A1L8ETN2
uniprot id: A0A8J0TKW2
uniprot id: A0A8J0TSR7
uniprot id: A0A8J1LUQ6
uniprot id: A0A8J1LUQ9
uniprot id: A0A8J1LUR3
uniprot id: A0A8J1LUR4
uniprot id: A0A8J1LVA1
uniprot id: A0A8J1LW54
uniprot id: A0A8J1LX09
uniprot id: A0A974BX70
names: Function
names: Subcellular Location Annotation
messages: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: ruffle

8355:naga.L
gene id: 8355:naga.L
uniprot id: A0A1L8EXG5
uniprot id: A0A974C0I4
uniprot id: Q6GR44
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

8355:xpo5.S
gene id: 8355:xpo5.S
uniprot id: A0A1L8G0T7
uniprot id: A0A8J0VJT6
uniprot id: A0A974CQ09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

8355:spam1.L
gene id: 8355:spam1.L
uniprot id: Q8UVT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Membrane

8355:plp1.S
gene id: 8355:plp1.S
uniprot id: A0A8J0TKW3
uniprot id: A0A8J1LL63
uniprot id: P23290
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Cell membrane
messages: Membrane
messages: This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.

8355:aoc3.L
gene id: 8355:aoc3.L
uniprot id: A0A8J1LPY7
uniprot id: Q6DCR9
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

8355:mrps16.L
gene id: 8355:mrps16.L
uniprot id: A0A974CG12
uniprot id: Q08AX5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

8355:LOC108709238
gene id: 8355:LOC108709238
uniprot id: A0A1L8H599
uniprot id: A0A8J1MDD7
uniprot id: A0A974DH32
names: Subcellular Location Annotation
messages: Nucleus

8355:dph5.S
gene id: 8355:dph5.S
uniprot id: A0A1L8GGJ2
uniprot id: A0A974D2G3
uniprot id: A0A974HMD6
uniprot id: Q7SYW0
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

8355:slc39a1l.S
gene id: 8355:slc39a1l.S
uniprot id: A0A1L8GSS4
names: Subcellular Location Annotation
messages: Membrane

8355:slc37a4.L
gene id: 8355:slc37a4.L
uniprot id: A0A1L8FLK3
uniprot id: A0A974CFW3
uniprot id: Q6PA19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

8355:rnpep.L
gene id: 8355:rnpep.L
uniprot id: A0A1L8HEP1
uniprot id: A0A8J0UCC0
uniprot id: A0A974HXY5
uniprot id: Q641C7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

8355:ndrg3.S
gene id: 8355:ndrg3.S
uniprot id: A0A8J0TXU1
uniprot id: Q6GQL1
names: Similarity
messages: Belongs to the NDRG family.

8355:LOC108697455
gene id: 8355:LOC108697455
uniprot id: A0A8J0TDZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

8355:ppp4r3a.S
gene id: 8355:ppp4r3a.S
uniprot id: A0A974C1Y4
uniprot id: Q6INN7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMEK family.
messages: Regulatory subunit of serine/threonine-protein phosphatase 4.
messages: Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits.

8355:gpr107.S
gene id: 8355:gpr107.S
uniprot id: Q5XG03
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108703376
gene id: 8355:LOC108703376
uniprot id: A0A8J0U1V5
uniprot id: A0A8J1LEK2
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

8355:colec11.L
gene id: 8355:colec11.L
uniprot id: Q7T0T0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COLEC10/COLEC11 family.
messages: Homotrimer; disulfide-linked. Interacts with MASP1; probably triggers the lectin pathway of complement.
messages: Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding. Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis.
messages: Secreted

8355:cacng1.S
gene id: 8355:cacng1.S
uniprot id: A0A1L8ENA3
uniprot id: A0A974BTV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.
messages: Membrane
messages: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.
messages: sarcolemma

8355:parp8.S
gene id: 8355:parp8.S
uniprot id: A0A1L8HRL6
uniprot id: A0A8J1M625
uniprot id: A0A974DVK2
names: Similarity
messages: Belongs to the ARTD/PARP family.

8355:LOC108717483
gene id: 8355:LOC108717483
uniprot id: A0A1L8G4W5
uniprot id: A0A974CSW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

8355:LOC121402179
gene id: 8355:LOC121402179
uniprot id: A0A1L8GTS1
uniprot id: A0A8J1MRF4
uniprot id: A0A8J1MSQ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:MGC53786
gene id: 8355:MGC53786
uniprot id: A0A1L8F3E8
uniprot id: A0A8J1LKF4
uniprot id: A0A974C538
uniprot id: Q7ZWS0
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PTBP2; the interaction is direct.
messages: Nucleus

8355:nkx3-3.S
gene id: 8355:nkx3-3.S
uniprot id: A0A974CBN5
uniprot id: O93590
names: Developmental Stage
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: At early tailbud stage, expressed in the pharyngeal endoderm, concentrated within the pharyngeal clefts. Also expressed in the mesenchymal head cells in the future infrarostral cartilage. Beginning at the mid-tailbud stage, expressed in the muscular layer of the midgut.
messages: Based on similarity to Drosophila 'bagpipe/bap', the name 'zampogna' was chosen after an Italian musical instrument related to the Scottish bagpipe.
messages: Belongs to the NK-3 homeobox family.
messages: Expressed at a low level throughout all developmental stages. Expression levels significantly increase after the mid-tailbud stage and are maintained through the tadpole stage (stage 40).
messages: Nucleus

8355:lin52.S
gene id: 8355:lin52.S
uniprot id: A0A1L8F0M9
uniprot id: A0A8J0TNI0
uniprot id: A0A974C2A6
names: Similarity
messages: Belongs to the lin-52 family.

8355:slc44a5.S
gene id: 8355:slc44a5.S
uniprot id: A0A1L8GFK4
uniprot id: A0A8J1KIT9
uniprot id: A0A8J1KM01
uniprot id: A0A974D1P5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

8355:LOC121394307
gene id: 8355:LOC121394307
uniprot id: A0A8J1KVQ6
names: Similarity
messages: Belongs to the HARBI1 family.

8355:plk1.L
gene id: 8355:plk1.L
uniprot id: A0A1L8EYC7
uniprot id: A0A974C1H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Midbody
messages: Nucleus
messages: centrosome

8355:zbed6cl.S
gene id: 8355:zbed6cl.S
uniprot id: A0A8J0T7N1
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108701415
gene id: 8355:LOC108701415
uniprot id: A0A8J0TMU6
uniprot id: A0A8J0TMV1
uniprot id: A0A8J0TMV6
uniprot id: A0A8J0TUU8
uniprot id: A0A8J0TUV3
uniprot id: A0A8J0TUV7
uniprot id: A0A8J0TVA9
uniprot id: A0A8J0TVB4
uniprot id: A0A8J0TVB9
uniprot id: A0A8J0TWG0
uniprot id: A0A8J0TWG4
uniprot id: A0A8J0TWG9
uniprot id: A0A8J0TWH4
uniprot id: A0A8J0TXV1
uniprot id: A0A8J0TXW2
uniprot id: A0A8J1LSF4
uniprot id: A0A8J1LSH5
uniprot id: A0A8J1LT50
uniprot id: A0A8J1LT55
uniprot id: A0A8J1LTW8
uniprot id: A0A8J1LTX3
uniprot id: A0A8J1LUT1
uniprot id: A0A8J1LUT5
names: Similarity
messages: Belongs to the LRRFIP family.

8355:LOC100037118
gene id: 8355:LOC100037118
uniprot id: A2RRW8
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC108695881
gene id: 8355:LOC108695881
uniprot id: A0A8J0T8X6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:nt5dc3.S
gene id: 8355:nt5dc3.S
uniprot id: A0A1L8GUS0
uniprot id: A0A974HRQ6
uniprot id: Q6GN91
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

8355:LOC108712655
gene id: 8355:LOC108712655
uniprot id: A0A8J0UP07
uniprot id: A0A8J1MQB7
uniprot id: A0A8J1MQH0
uniprot id: A0A8J1MRI8
names: Subcellular Location Annotation
messages: Membrane

8355:hpcal1.L
gene id: 8355:hpcal1.L
uniprot id: Q6DCM9
names: Miscellaneous
names: Similarity
messages: Belongs to the recoverin family.
messages: Probably binds two or three calcium ions.

8355:gdf15.S
gene id: 8355:gdf15.S
uniprot id: A0A1L8HNP6
uniprot id: A0A974I0W0
names: Similarity
messages: Belongs to the TGF-beta family.

8355:zfyve9.S
gene id: 8355:zfyve9.S
uniprot id: A0A1L8GFZ5
uniprot id: A0A974HLR5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane

8355:cryab.S
gene id: 8355:cryab.S
uniprot id: A0A8J0TEF4
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

8355:s100a1.S
gene id: 8355:s100a1.S
uniprot id: A0A1L8F549
uniprot id: A0A974H718
names: Similarity
messages: Belongs to the S-100 family.

8355:cnot2.S
gene id: 8355:cnot2.S
uniprot id: A0A1L8GUI7
uniprot id: A0A974DAY4
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

8355:ifi30.S
gene id: 8355:ifi30.S
uniprot id: A0A1L8HNI6
uniprot id: A0A974I0U2
names: Similarity
names: Subunit
messages: Belongs to the GILT family.
messages: Dimer; disulfide-linked.

8355:etv1.S
gene id: 8355:etv1.S
uniprot id: A0A1L8FR53
uniprot id: A0A8J0VLQ2
uniprot id: A0A974HDM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8355:gfra3.S
gene id: 8355:gfra3.S
uniprot id: A0A1L8GUZ8
uniprot id: A0A974D8T6
names: Similarity
messages: Belongs to the GDNFR family.

8355:nbl1.S
gene id: 8355:nbl1.S
uniprot id: A0A1L8FHM0
uniprot id: A0A974CDF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

8355:LOC108719484
gene id: 8355:LOC108719484
uniprot id: A0A1L8G0I0
uniprot id: A0A8J0VLS5
uniprot id: A0A974CQC9
names: Similarity
messages: Belongs to the oxoprolinase family.

8355:stk11.L
gene id: 8355:stk11.L
uniprot id: A0A974DZS4
uniprot id: Q91604
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.
messages: Catalytic component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta).
messages: Cytoplasm
messages: Its expression peaks in the oocyte and unfertilized egg, begins to decrease gradually after fertilization, and disappears during the gastrulation stage.
messages: Nucleus
messages: Oocytes, eggs and early embryos.
messages: Phosphorylated by a cAMP-dependent protein kinase. Autophosphorylated in a reaction that prefers Mn(2+) to Mg(2+).
messages: Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity (By similarity).

8355:pola1.S
gene id: 8355:pola1.S
uniprot id: A0A8J1MCY2
uniprot id: Q9DE46
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-B family.
messages: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
messages: Nucleus
messages: Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes (By similarity).
messages: The DNA polymerase alpha complex is composed of four subunits: the catalytic subunit POLA1, the regulatory subunit POLA2, and the small and the large primase subunits PRIM1 and PRIM2 respectively. Interacts with PARP1; this interaction functions as part of the control of replication fork progression. Interacts with MCM10 and WDHD1; these interactions recruit the polymerase alpha complex to the pre-replicative complex bound to DNA. Interacts with RPA1; this interaction stabilizes the replicative complex and reduces the misincorporation rate of DNA polymerase alpha by acting as a fidelity clamp (By similarity).

8355:cdc42.L
gene id: 8355:cdc42.L
uniprot id: A0A1L8FGB8
uniprot id: A0A974CID9
uniprot id: Q9DDV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Membrane
messages: Midbody
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.

8355:kcnq5.S
gene id: 8355:kcnq5.S
uniprot id: A0A8J0VFG1
uniprot id: A0A8J1KTG0
uniprot id: A0A8J1KV21
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108706882
gene id: 8355:LOC108706882
uniprot id: A0A8J0U112
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

8355:kif9.S
gene id: 8355:kif9.S
uniprot id: A0A1L8FQB1
uniprot id: A0A974HDD1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8355:bzw1.L
gene id: 8355:bzw1.L
uniprot id: A0A974C097
uniprot id: Q8AVM7
names: Function
names: Similarity
messages: Belongs to the BZW family.
messages: Translation initiation regulator which may repress repeat-associated non-AUG (RAN) initiated translation probably by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (By similarity). Enhances histone H4 gene transcription but does not seem to bind DNA directly (By similarity).

8355:gchfr.S
gene id: 8355:gchfr.S
uniprot id: A0A1L8F482
uniprot id: A0A974C582
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GFRP family.
messages: Membrane
messages: Nucleus membrane
messages: cytosol

8355:LOC108700444
gene id: 8355:LOC108700444
uniprot id: A0A1L8F595
uniprot id: A0A8J1LLV9
uniprot id: A0A8J1LM14
uniprot id: A0A8J1LMZ2
names: Subcellular Location Annotation
messages: cytoskeleton

8355:vwa2.S
gene id: 8355:vwa2.S
uniprot id: Q6DCQ6
names: Subcellular Location Annotation
names: Subunit
messages: Forms monomers and multimers.
messages: Secreted

8355:nop16.L
gene id: 8355:nop16.L
uniprot id: A0A1L8GXT4
uniprot id: A0A974DBA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP16 family.
messages: nucleolus

8355:LOC108703680
gene id: 8355:LOC108703680
uniprot id: A0A8J1M3W2
uniprot id: A0A8J1M4L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM6SF family.
messages: Membrane

8355:MGC147631.L
gene id: 8355:MGC147631.L
uniprot id: A0A8J1KW58
uniprot id: A0A8J1KW61
uniprot id: A0A974CMB6
uniprot id: Q0IHH7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

8355:LOC121394208
gene id: 8355:LOC121394208
uniprot id: A0A8J1KT20
uniprot id: A0A8J1KT26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat peroxin-7 family.
messages: Peroxisome matrix
messages: cytosol

8355:arl5b.S
gene id: 8355:arl5b.S
uniprot id: A0A974CIF4
uniprot id: Q5M783
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

8355:ckb.S
gene id: 8355:ckb.S
uniprot id: A0A8J1LMD9
uniprot id: A0A8J1LPR8
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

8355:LOC108703828
gene id: 8355:LOC108703828
uniprot id: A0A8J0U620
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natural cytotoxicity receptor (NCR) family.
messages: Cell membrane
messages: Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6.
messages: Membrane

8355:app.L
gene id: 8355:app.L
uniprot id: A0A8J0U3H6
uniprot id: A0A8J0UBN2
uniprot id: A0A8J0UEB3
uniprot id: Q6NRR1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:polr1d.2.L
gene id: 8355:polr1d.2.L
uniprot id: A0A974H7X1
uniprot id: Q5XK67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity).
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.
messages: Nucleus

8355:rps28p9.L
gene id: 8355:rps28p9.L
uniprot id: A0A974DZW0
uniprot id: Q66KP7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

8355:mesd.L
gene id: 8355:mesd.L
uniprot id: A0A1L8H0X7
uniprot id: A0A974HTW4
uniprot id: Q4V7K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MESD family.
messages: Endoplasmic reticulum

8355:nkx6-2.S
gene id: 8355:nkx6-2.S
uniprot id: A0A1L8FED6
uniprot id: A0A974CBH3
names: Subcellular Location Annotation
messages: Nucleus

8355:atxn1.L
gene id: 8355:atxn1.L
uniprot id: A0A8J1KY62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

8355:brpf3.S
gene id: 8355:brpf3.S
uniprot id: A0A1L8H6R5
uniprot id: A0A974DHD0
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108712908
gene id: 8355:LOC108712908
uniprot id: A0A8J0UWQ7
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

8355:inka2.L
gene id: 8355:inka2.L
uniprot id: A0A1L8HF17
uniprot id: A0A974DMF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

8355:lin52.L
gene id: 8355:lin52.L
uniprot id: A0A8J0THW3
uniprot id: A0A8J0TKB9
names: Similarity
messages: Belongs to the lin-52 family.

8355:LOC121397328
gene id: 8355:LOC121397328
uniprot id: A0A8J1LKU2
names: Subcellular Location Annotation
messages: Membrane

8355:MGC82342
gene id: 8355:MGC82342
uniprot id: Q6INM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

8355:btg1.S
gene id: 8355:btg1.S
uniprot id: Q9PVQ0
names: Similarity
messages: Belongs to the BTG family.

8355:slc35c1.L
gene id: 8355:slc35c1.L
uniprot id: A0A1L8GIT0
uniprot id: A0A8J0V033
uniprot id: A0A8J1MXM7
uniprot id: A0A974HN64
names: Subcellular Location Annotation
messages: Membrane

8355:tmem50b.S
gene id: 8355:tmem50b.S
uniprot id: A0A1L8H596
uniprot id: A0A974DH26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

8355:rad9a.L
gene id: 8355:rad9a.L
uniprot id: A0A8J0SZ53
uniprot id: A0A974HBS1
uniprot id: Q7ZZU5
names: Similarity
messages: Belongs to the rad9 family.

8355:LOC121393122
gene id: 8355:LOC121393122
uniprot id: A0A8J1MRP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: nucleolus

8355:il16.L
gene id: 8355:il16.L
uniprot id: A0A1L8H0P9
uniprot id: A0A974DCY3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homotetramer.
messages: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
messages: Nucleus
messages: Secreted

8355:fpgs.L
gene id: 8355:fpgs.L
uniprot id: A0A8J1LI09
uniprot id: A0A8J1LI43
uniprot id: A0A8J1LJD5
names: Cofactor
names: Function
names: Similarity
messages: A monovalent cation.
messages: Belongs to the folylpolyglutamate synthase family.
messages: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.

8355:csrnp1.L
gene id: 8355:csrnp1.L
uniprot id: Q63ZQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

8355:cdca8.L
gene id: 8355:cdca8.L
uniprot id: A0A1L8HFF1
uniprot id: A0A8J0UAW0
uniprot id: A0A974DQG3
uniprot id: Q3KPK4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the borealin family.
messages: Component of the CPC at least composed of survivin/birc5, incenp, cdca8/borealin and/or cdca9/dasra-A, and aurkb/aurora-B. Interacts with incenp (via N-terminus).
messages: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Contributes to CPC function by facilitating loading of the CPC onto chromosomes.
messages: Nucleus
messages: Was named 'Dasra' in reference to the Hindu mythological deity Dasra, who acts as a harbinger of the dawn.
messages: centromere
messages: spindle

8355:fdxr.S
gene id: 8355:fdxr.S
uniprot id: A0A1L8EMR0
uniprot id: A0A974BTS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferredoxin--NADP reductase type 1 family.
messages: Mitochondrion
messages: Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.

8355:rpl7a.S
gene id: 8355:rpl7a.S
uniprot id: Q6GQB2
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the ribosome.

8355:pkn1.L
gene id: 8355:pkn1.L
uniprot id: A0A1L8H2L2
uniprot id: A0A8J0UTG4
uniprot id: A0A8J1MNW1
uniprot id: A0A8J1MNY0
uniprot id: A0A8J1MQ00
uniprot id: A0A974DEH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Nucleus

8355:psma3.S
gene id: 8355:psma3.S
uniprot id: Q6PE96
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

8355:dkk2.L
gene id: 8355:dkk2.L
uniprot id: A0A974DZ28
uniprot id: Q9DDA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

8355:scd.L
gene id: 8355:scd.L
uniprot id: A2RRT2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

8355:cx38.S
gene id: 8355:cx38.S
uniprot id: Q6NUE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8355:map7d2.L
gene id: 8355:map7d2.L
uniprot id: A0A1L8HDK4
uniprot id: A0A8J0UE64
uniprot id: A0A8J0UGU4
uniprot id: A0A8J1M7Q7
uniprot id: A0A8J1M7R3
uniprot id: A0A8J1M7R4
uniprot id: A0A8J1M7R9
uniprot id: A0A8J1M7W6
uniprot id: A0A8J1M7X1
uniprot id: A0A8J1M8T2
uniprot id: A0A8J1M8T7
uniprot id: A0A8J1M9K1
uniprot id: A0A8J1M9K3
uniprot id: A0A974DLM4
names: Similarity
messages: Belongs to the MAP7 family.

8355:dstyk.S
gene id: 8355:dstyk.S
uniprot id: Q67E01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm
messages: May act as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death. May play a role in the embryonic development.

8355:cpo.3.L
gene id: 8355:cpo.3.L
uniprot id: A0A8J0TWS2
names: Similarity
messages: Belongs to the peptidase M14 family.

8355:LOC108710405
gene id: 8355:LOC108710405
uniprot id: A0A8J1MKM6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:fam3b.L
gene id: 8355:fam3b.L
uniprot id: A0A1L8HCE6
uniprot id: A0A8J0UG22
uniprot id: A0A8J1M8U8
uniprot id: A0A974DKW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

8355:LOC108699177
gene id: 8355:LOC108699177
uniprot id: A0A8J0TD01
uniprot id: A0A8J0TJ79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM151 family.
messages: Membrane

8355:LOC121403083
gene id: 8355:LOC121403083
uniprot id: A0A8J1MXF4
uniprot id: A0A8J1MYL1
uniprot id: A0A8J1MZX1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108718175
gene id: 8355:LOC108718175
uniprot id: A0A8J1KUC6
uniprot id: A0A8J1KUD2
uniprot id: A0A8J1KXD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:zdhhc3.L
gene id: 8355:zdhhc3.L
uniprot id: Q6DCL3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:smarca4.S
gene id: 8355:smarca4.S
uniprot id: Q4VQ79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

8355:tspan9.L
gene id: 8355:tspan9.L
uniprot id: A0A8J1MJP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8355:smug1.L
gene id: 8355:smug1.L
uniprot id: Q9YGN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.
messages: Nucleus
messages: Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. Does not exhibit any enzymatic activity towards G/T mismatches.

8355:LOC108717630
gene id: 8355:LOC108717630
uniprot id: A0A1L8G0Q7
uniprot id: A0A8J1KS47
uniprot id: A0A8J1KV60
uniprot id: A0A974CRL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.
messages: Cytoplasm
messages: Nucleus

8355:map7d1.L
gene id: 8355:map7d1.L
uniprot id: A0A8J0U666
uniprot id: A0A8J0UD38
uniprot id: A0A8J0UEI1
uniprot id: A0A8J1M806
names: Similarity
messages: Belongs to the MAP7 family.

8355:fen1.L
gene id: 8355:fen1.L
uniprot id: A0A974D482
uniprot id: P70040
names: Cofactor
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: First expressed at a low level in stage II oocytes. Expression increases dramatically from oocyte stages III to V (at protein level). Also expressed in embryos.
messages: Interacts with PCNA. Three molecules of fen1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Mitochondrion
messages: Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

8355:ormdl2.L
gene id: 8355:ormdl2.L
uniprot id: A0A1L8HHY5
uniprot id: A0A974DRY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

8355:LOC108706526
gene id: 8355:LOC108706526
uniprot id: A0A1L8HKT8
uniprot id: A0A974DSI6
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108719816
gene id: 8355:LOC108719816
uniprot id: A0A8J0VJ86
uniprot id: A0A8J1L154
uniprot id: A0A8J1L159
uniprot id: A0A8J1L160
uniprot id: A0A8J1L171
uniprot id: A0A8J1L2S1
uniprot id: A0A8J1L3Y3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

8355:LOC121393302
gene id: 8355:LOC121393302
uniprot id: A0A8J1KW79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

8355:nme9.L
gene id: 8355:nme9.L
uniprot id: Q6IRC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Dynein axonemal particle
messages: May be a regulator of microtubule physiology.
messages: Monomer and homodimer.
messages: cilium axoneme

8355:scamp2.L
gene id: 8355:scamp2.L
uniprot id: A0A974DCI8
uniprot id: Q68EW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

8355:LOC121400486
gene id: 8355:LOC121400486
uniprot id: A0A8J1MEU2
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:LOC121401356
gene id: 8355:LOC121401356
uniprot id: A0A8J1MJ42
names: Subcellular Location Annotation
messages: Membrane

8355:cdc42se1.L
gene id: 8355:cdc42se1.L
uniprot id: A0A974H944
uniprot id: Q6GPV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly.
messages: cytoskeleton

8355:LOC121398676
gene id: 8355:LOC121398676
uniprot id: A0A8J1LVG4
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:LOC121394357
gene id: 8355:LOC121394357
uniprot id: A0A8J1KWH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

8355:cops7b.L
gene id: 8355:cops7b.L
uniprot id: A0A8J0U824
uniprot id: Q66J43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

8355:LOC121397756
gene id: 8355:LOC121397756
uniprot id: A0A1L8F3C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8355:clgn.L
gene id: 8355:clgn.L
uniprot id: A0A8J0TE94
names: Similarity
messages: Belongs to the calreticulin family.

8355:bccip.S
gene id: 8355:bccip.S
uniprot id: A0A1L8FEE3
uniprot id: A0A974CB70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCP1 family.
messages: spindle pole

8355:st8sia2.L
gene id: 8355:st8sia2.L
uniprot id: O93234
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8355:LOC108716733
gene id: 8355:LOC108716733
uniprot id: A0A8J0V7J9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8355:fxyd6.L
gene id: 8355:fxyd6.L
uniprot id: A0A1L8FLL3
uniprot id: A0A974CH19
names: Similarity
messages: Belongs to the FXYD family.

8355:gbe1.L
gene id: 8355:gbe1.L
uniprot id: Q6DFJ1
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

8355:polr1h.L
gene id: 8355:polr1h.L
uniprot id: A0A1L8GZV4
uniprot id: A0A974DEH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.
messages: nucleolus

8355:psma1.S
gene id: 8355:psma1.S
uniprot id: Q5XGP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

8355:LOC121394604
gene id: 8355:LOC121394604
uniprot id: A0A8J1KXD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT10 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
messages: Cytoplasm
messages: Nucleus

8355:golm1.L
gene id: 8355:golm1.L
uniprot id: A0A1L8HYD6
uniprot id: A0A8J0U9Q8
uniprot id: A0A8J0UHY9
uniprot id: A0A8J1M7A1
uniprot id: A0A974E222
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

8355:tfcp2.L
gene id: 8355:tfcp2.L
uniprot id: A0A974HZ27
uniprot id: Q4V860
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Component of the SSP (stage selector protein) complex, which appears to be a heteromer of TFCP2 and 2 copies of NFE4.
messages: May function as a transcription factor.
messages: Nucleus

8355:LOC108707553
gene id: 8355:LOC108707553
uniprot id: A0A8J1M9W9
uniprot id: A0A8J1MA65
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

8355:agbl2.L
gene id: 8355:agbl2.L
uniprot id: A0A1L8GJ01
uniprot id: A0A974D293
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

8355:atf7.L
gene id: 8355:atf7.L
uniprot id: A0A8J0UGR2
uniprot id: A0A8J1MBR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

8355:gmpr2.S
gene id: 8355:gmpr2.S
uniprot id: A0A974DUZ9
uniprot id: Q6GMC9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108698938
gene id: 8355:LOC108698938
uniprot id: A0A8J1MUH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8355:otud7b.L
gene id: 8355:otud7b.L
uniprot id: A0A1L8FC26
uniprot id: A0A8J0TDQ7
uniprot id: A0A974C9N4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:f9.L
gene id: 8355:f9.L
uniprot id: A0A1L8F826
uniprot id: A0A974C6R9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:ppfibp1.S
gene id: 8355:ppfibp1.S
uniprot id: A0A8J0UMD3
uniprot id: A0A8J0UT62
uniprot id: A0A8J0UU91
uniprot id: A0A8J0UU96
uniprot id: A0A8J0UUD2
uniprot id: A0A8J0UXQ3
uniprot id: Q6DD79
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

8355:mllt11.S
gene id: 8355:mllt11.S
uniprot id: A0A1L8F4M6
uniprot id: A0A8J0THX2
uniprot id: A0A974C4X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLLT11 family.
messages: Nucleus
messages: centrosome

8355:khsrp.L
gene id: 8355:khsrp.L
uniprot id: A0A8J0QDG6
uniprot id: B1WBB7
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108698404
gene id: 8355:LOC108698404
uniprot id: A0A8J0TAP2
names: Subcellular Location Annotation
messages: Membrane

8355:cmc1.L
gene id: 8355:cmc1.L
uniprot id: A0A974CN45
uniprot id: Q6NRY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

8355:hephl1.L
gene id: 8355:hephl1.L
uniprot id: A0A1L8HJC5
uniprot id: A0A974DRD9
names: Similarity
messages: Belongs to the multicopper oxidase family.

8355:ilkap.L
gene id: 8355:ilkap.L
uniprot id: A0A8J0V5A5
uniprot id: A0A8J0V960
uniprot id: A0A8J0V9S0
uniprot id: A0A8J1KRI5
uniprot id: Q6AZM6
names: Similarity
messages: Belongs to the PP2C family.

8355:aldh1a2.L
gene id: 8355:aldh1a2.L
uniprot id: A0A974DEK5
uniprot id: Q9DEX5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

8355:hbz.L
gene id: 8355:hbz.L
uniprot id: Q3KQ67
names: Similarity
messages: Belongs to the globin family.

8355:LOC108699570
gene id: 8355:LOC108699570
uniprot id: A0A1L8FBP6
uniprot id: A0A974C9I2
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:rwdd3.L
gene id: 8355:rwdd3.L
uniprot id: A0A8J0UX92
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:LOC108706636
gene id: 8355:LOC108706636
uniprot id: A0A1L8HLJ7
uniprot id: A0A8J0U792
uniprot id: A0A8J1M176
uniprot id: A0A8J1M2A9
uniprot id: A0A974DUB3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:uba3.L
gene id: 8355:uba3.L
uniprot id: A0A1L8GQ11
uniprot id: A0A8J0V863
uniprot id: A0A974D5D5
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.

8355:LOC108702571
gene id: 8355:LOC108702571
uniprot id: A0A1L8ELA2
uniprot id: A0A974H0B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8355:prr15.L
gene id: 8355:prr15.L
uniprot id: A0A1L8FW39
uniprot id: A0A974HF96
names: Similarity
messages: Belongs to the PRR15 family.

8355:LOC121399682
gene id: 8355:LOC121399682
uniprot id: A0A8J1M640
names: Subcellular Location Annotation
messages: Membrane

8355:acvr1c.L
gene id: 8355:acvr1c.L
uniprot id: A0A1L8EVX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

8355:avpi1.S
gene id: 8355:avpi1.S
uniprot id: A0A1L8FF30
uniprot id: A0A8J0TE17
uniprot id: A0A974H9U0
names: Function
messages: May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling.

8355:tor4a.L
gene id: 8355:tor4a.L
uniprot id: A0A1L8F5N1
uniprot id: A0A974H6P4
uniprot id: Q3KQ18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Membrane

8355:LOC108713433
gene id: 8355:LOC108713433
uniprot id: A0A8J1MUM9
uniprot id: A0A8J1MUW8
uniprot id: A0A8J1MVS5
uniprot id: A0A8J1MW55
uniprot id: A0A8J1MX31
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.

8355:ypel1.L
gene id: 8355:ypel1.L
uniprot id: A0A974I5F9
uniprot id: Q6DDQ0
names: Similarity
messages: Belongs to the yippee family.

8355:mcts1.L
gene id: 8355:mcts1.L
uniprot id: A0A974C6Q1
uniprot id: Q6NRJ7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm
messages: Plays a role as translation enhancer and involved in cell cycle regulation.
messages: The PUA RNA-binding domain is critical for cap binding, but not sufficient for translation enhancer function.

8355:or51e1.L
gene id: 8355:or51e1.L
uniprot id: A0A8J0UD59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:rbm8a.S
gene id: 8355:rbm8a.S
uniprot id: A0A974C5Q9
uniprot id: Q9DF42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM8A family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
messages: Cytoplasm
messages: Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.
messages: Nucleus
messages: Nucleus speckle
messages: Part of the EJC core complex that contains casc3, eif4a3, magoh and rbm8a. Identified in the spliceosome C complex.
messages: Required for pre-mRNA splicing as component of the spliceosome (By similarity). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs (By similarity).

8355:LOC108700607
gene id: 8355:LOC108700607
uniprot id: A0A8J1LP02
names: Similarity
messages: Belongs to the MHC class I family.

8355:LOC108706545
gene id: 8355:LOC108706545
uniprot id: A0A1L8HKV6
uniprot id: A0A8J0U6Z0
uniprot id: A0A8J0U7S6
uniprot id: A0A8J0U874
uniprot id: A0A8J0UAI9
uniprot id: A0A974DRG6
names: Similarity
messages: Belongs to the RRM CPEB family.

8355:ablim1.S
gene id: 8355:ablim1.S
uniprot id: A0A8J1L9K9
uniprot id: A0A8J1L9L0
uniprot id: A0A8J1L9L4
uniprot id: A0A8J1L9L6
uniprot id: A0A8J1L9L9
uniprot id: A0A8J1L9M1
uniprot id: A0A8J1L9M5
uniprot id: A0A8J1L9M6
uniprot id: A0A8J1L9P7
uniprot id: A0A8J1L9Q2
uniprot id: A0A8J1L9Q7
uniprot id: A0A8J1LB59
uniprot id: A0A8J1LB64
uniprot id: A0A8J1LB70
uniprot id: A0A8J1LC35
uniprot id: A0A8J1LC41
uniprot id: A0A8J1LC46
uniprot id: A0A8J1LC50
uniprot id: B1H1T4
names: Subcellular Location Annotation
messages: Cytoplasm

8355:b4galt4.L
gene id: 8355:b4galt4.L
uniprot id: A0A1L8HC16
uniprot id: A0A974DKG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

8355:slc15a4.S
gene id: 8355:slc15a4.S
uniprot id: A0A1L8HQJ2
uniprot id: A0A974DWX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

8355:clic1.S
gene id: 8355:clic1.S
uniprot id: A0A1L8F3N4
uniprot id: A0A974H6J4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane
messages: Nucleus membrane

8355:LOC108716548
gene id: 8355:LOC108716548
uniprot id: A0A1L8G795
uniprot id: A0A974CW27
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:clu.L
gene id: 8355:clu.L
uniprot id: A0A974CX16
uniprot id: Q7ZWW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higher oligomers.
messages: Belongs to the clusterin family.
messages: Endoplasmic reticulum
messages: Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.
messages: Membrane
messages: Mitochondrion membrane
messages: Nucleus
messages: Secreted
messages: chromaffin granule
messages: cytosol

8355:cyp2f1.S
gene id: 8355:cyp2f1.S
uniprot id: Q6PA33
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:gsc.L
gene id: 8355:gsc.L
uniprot id: A0A1L8F9K8
uniprot id: A0A974C7V0
names: Subcellular Location Annotation
messages: Nucleus

8355:tmem255b.L
gene id: 8355:tmem255b.L
uniprot id: A0A8J1M6B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

8355:rps6.S
gene id: 8355:rps6.S
uniprot id: A0A974DTQ5
uniprot id: P39017
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS6 family.
messages: Component of the 40S small ribosomal subunit. Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Cytoplasm
messages: Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest.
messages: nucleolus

8355:LOC108719722
gene id: 8355:LOC108719722
uniprot id: A0A8J1L582
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

8355:LOC108707926
gene id: 8355:LOC108707926
uniprot id: A0A1L8HCY5
uniprot id: A0A974DLP5
names: Subcellular Location Annotation
messages: Membrane

8355:smg9.S
gene id: 8355:smg9.S
uniprot id: Q05AW9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMG9 family.
messages: Component of the SMG1C complex composed of smg1, smg8 and smg9.
messages: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with smg1 and smg8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between smg1 and smg8 (By similarity).

8355:lsm5.L
gene id: 8355:lsm5.L
uniprot id: A0A8J0VMX1
uniprot id: A0A974HFI7
uniprot id: Q66L31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

8355:ppp4r3b.S
gene id: 8355:ppp4r3b.S
uniprot id: A0A8J1KUC9
uniprot id: A0A974CSV8
uniprot id: Q801Q7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMEK family.
messages: Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4).
messages: Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits.

8355:ctnnb1.S
gene id: 8355:ctnnb1.S
uniprot id: A0A974CIX5
uniprot id: A0A974CJ64
uniprot id: A1A5I6
uniprot id: Q7ZX35
names: Similarity
messages: Belongs to the beta-catenin family.

8355:pdgfrl.L
gene id: 8355:pdgfrl.L
uniprot id: Q6INL1
names: Subunit
messages: Forms a complex composed of PDGFRL, TNK2 and GRB2.

8355:LOC108719466
gene id: 8355:LOC108719466
uniprot id: A0A1L8G0E9
uniprot id: A0A974CPP5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8355:rps27.L
gene id: 8355:rps27.L
uniprot id: A0A1L8EJM5
uniprot id: A0A8J1LKU3
uniprot id: A0A974GY26
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

8355:isoc2.S
gene id: 8355:isoc2.S
uniprot id: Q5PQ71
names: Similarity
messages: Belongs to the isochorismatase family.

8355:ints3.L
gene id: 8355:ints3.L
uniprot id: A0A1L8FD93
uniprot id: A0A974CBI9
names: Similarity
messages: Belongs to the Integrator subunit 3 family.

8355:LOC108712299
gene id: 8355:LOC108712299
uniprot id: A0A8J0UYH8
names: Similarity
messages: Belongs to the FAH family.

8355:tagln.L
gene id: 8355:tagln.L
uniprot id: Q6P7J3
names: Similarity
messages: Belongs to the calponin family.

8355:parp2.L
gene id: 8355:parp2.L
uniprot id: A0A1L8HZS1
uniprot id: A0A8J0V4M2
uniprot id: A0A974I4N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

8355:brinp2.L
gene id: 8355:brinp2.L
uniprot id: A0A1L8GMN5
uniprot id: A0A974HPJ1
names: Similarity
messages: Belongs to the BRINP family.

8355:LOC108707893
gene id: 8355:LOC108707893
uniprot id: A0A8J1M783
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:LOC108695813
gene id: 8355:LOC108695813
uniprot id: A0A8J1L697
uniprot id: A0A8J1L6A2
uniprot id: A0A8J1L6A4
uniprot id: A0A8J1L6A9
uniprot id: A0A8J1L808
uniprot id: A0A8J1L8Y9
uniprot id: A0A8J1L8Z4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:LOC121396936
gene id: 8355:LOC121396936
uniprot id: A0A8J1LHJ5
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:slc35a5.S
gene id: 8355:slc35a5.S
uniprot id: A0A1L8H6P2
uniprot id: A0A974DIK8
uniprot id: Q6DCG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: Probable UDP-sugar:UMP transmembrane antiporter involved in UDP-alpha-D-glucuronate/UDP-GlcA, UDP-GlcNAc/UDP-N-acetyl-alpha-D-glucosamine and UDP-N-acetyl-alpha-D-galactosamine/UDP-GalNAc transport from the cytosol to the lumen of the Golgi.
messages: Probably forms homooligomers.

8355:LOC121393643
gene id: 8355:LOC121393643
uniprot id: A0A8J1KMS1
names: Similarity
messages: Belongs to the HARBI1 family.

8355:unc5a.S
gene id: 8355:unc5a.S
uniprot id: A0A8J0UV49
uniprot id: A0A8J1MS73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

8355:cdc14b.S
gene id: 8355:cdc14b.S
uniprot id: A0A1L8HPD0
uniprot id: A0A8J0TU74
uniprot id: A0A8J1LLU8
uniprot id: A0A8J1LMS5
uniprot id: A0A8J1LMV0
uniprot id: A0A8J1LMX2
uniprot id: A0A8J1LP87
uniprot id: A0A974DTZ8
uniprot id: Q6QLU4
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

8355:coq6.S
gene id: 8355:coq6.S
uniprot id: A0A1L8F0Q6
uniprot id: A0A974C3C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiH/COQ6 family.
messages: Cell projection
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ7.
messages: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
messages: Golgi apparatus
messages: Mitochondrion inner membrane

8355:eif3h.S
gene id: 8355:eif3h.S
uniprot id: Q5PPY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

8355:fundc1.S
gene id: 8355:fundc1.S
uniprot id: Q58EA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

8355:dazap1.S
gene id: 8355:dazap1.S
uniprot id: Q98SJ2
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of a mRNP complex, at least composed of DAZAP1, IGF2BP3-A, STAU and VgRBP60. Binds to the 3'-UTR of Vg1 mRNA. Interacts with profilin, a protein involved in actin assembly. Interacts with VgRBP71.
messages: Cytoplasm
messages: Expressed gradually during oogenesis. First expressed in stage I-II oocytes at a low level. Strongly expressed during stage III-IV, and thereafter for the remainder of oogenesis.
messages: Expressed in oocytes.
messages: RNA-binding protein, which is required during gametogenesis. May be involved in the actin-dependent anchoring of Vg1 mRNA in the vegetal cortex of the oocyte.

8355:eef1a1o.S
gene id: 8355:eef1a1o.S
uniprot id: A0A974BSC7
uniprot id: Q7ZXA2
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

8355:sarm1.S
gene id: 8355:sarm1.S
uniprot id: A0A1L8H506
uniprot id: A0A8J0UB27
uniprot id: A0A974DHL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SARM1 family.
messages: axon

8355:cnga3.S
gene id: 8355:cnga3.S
uniprot id: A0A1L8H8R5
uniprot id: A0A8J1MF47
names: Subcellular Location Annotation
messages: Membrane

8355:tnip2.S
gene id: 8355:tnip2.S
uniprot id: A0A1L8HKR2
uniprot id: A0A974DTR7
names: Subcellular Location Annotation
messages: Cytoplasm

8355:adora1.S
gene id: 8355:adora1.S
uniprot id: A0A1L8H6C7
uniprot id: A0A974DHS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

8355:syt14.S
gene id: 8355:syt14.S
uniprot id: A0A8J1KUR6
uniprot id: Q68EW3
names: Similarity
messages: Belongs to the synaptotagmin family.

8355:nfe2l2.S
gene id: 8355:nfe2l2.S
uniprot id: A0A8J1LVZ8
uniprot id: Q6GLL4
names: Similarity
messages: Belongs to the bZIP family. CNC subfamily.

8355:LOC108703550
gene id: 8355:LOC108703550
uniprot id: A0A8J0TUU0
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

8355:myo15a.L
gene id: 8355:myo15a.L
uniprot id: A0A8J1LU94
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8355:fgf4.L
gene id: 8355:fgf4.L
uniprot id: P48805
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: By derriere.
messages: Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Good candidate for an inducing factor with possible roles both in mesoderm induction at the blastula stage and in the formation of the anteroposterior axis at the gastrula stage.
messages: Secreted

8355:chrdl1.S
gene id: 8355:chrdl1.S
uniprot id: A0A8J1LN59
names: Subcellular Location Annotation
messages: Secreted

8355:krt59.L
gene id: 8355:krt59.L
uniprot id: A0A1L8HIM2
uniprot id: A0A974DPX5
names: Similarity
messages: Belongs to the intermediate filament family.

8355:LOC121399396
gene id: 8355:LOC121399396
uniprot id: A0A8J1M2K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANP32 family.
messages: Multifunctional protein that is involved in the regulation of many processes.
messages: Nucleus

8355:isoc1.L
gene id: 8355:isoc1.L
uniprot id: A0A8J0UAX6
uniprot id: A0A8J1MAR0
uniprot id: A0A974E234
uniprot id: Q5PQA5
names: Similarity
messages: Belongs to the isochorismatase family.

8355:LOC108700107
gene id: 8355:LOC108700107
uniprot id: A0A8J0TPI4
names: Subcellular Location Annotation
messages: Membrane

8355:cds2.L
gene id: 8355:cds2.L
uniprot id: A0A1L8H1G8
uniprot id: A0A974DF47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

8355:LOC108705437
gene id: 8355:LOC108705437
uniprot id: A0A8J1KSE2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:LOC108705674
gene id: 8355:LOC108705674
uniprot id: A0A310TM08
uniprot id: A0A974BPT6
uniprot id: P06900
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-121 by BRE1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: Phosphorylated on Ser-15 during developmentally programmed apoptosis; which may facilitate apoptotic chromatin condensation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:bak1.S
gene id: 8355:bak1.S
uniprot id: Q4KLS7
names: Similarity
messages: Belongs to the Bcl-2 family.

8355:LOC121399810
gene id: 8355:LOC121399810
uniprot id: A0A8J1M704
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:cryga.10.L
gene id: 8355:cryga.10.L
uniprot id: A0A8J0TWK8
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:synm.L
gene id: 8355:synm.L
uniprot id: A0A1L8H126
uniprot id: A0A974DEZ4
names: Similarity
messages: Belongs to the intermediate filament family.

8355:tmprss9.L
gene id: 8355:tmprss9.L
uniprot id: A0A1L8HVY8
uniprot id: A0A974DZX1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:LOC108696826
gene id: 8355:LOC108696826
uniprot id: A0A1L8FP17
uniprot id: A0A974HDC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF beta-subunit/FixA family.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

8355:LOC108717510
gene id: 8355:LOC108717510
uniprot id: A0A8J0VAZ8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:syne1.L
gene id: 8355:syne1.L
uniprot id: A0A8J0V7E0
uniprot id: A0A8J1KMW5
uniprot id: A0A8J1KMX3
uniprot id: A0A8J1KR05
names: Similarity
messages: Belongs to the nesprin family.

8355:btk.L
gene id: 8355:btk.L
uniprot id: A0A1L8F6P2
uniprot id: A0A974C667
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

8355:osbpl9.L
gene id: 8355:osbpl9.L
uniprot id: A0A1L8GME2
uniprot id: A0A8J0UX05
uniprot id: A0A8J0V1C5
uniprot id: A0A8J1MWZ1
uniprot id: A0A8J1MWZ6
uniprot id: A0A8J1MX88
uniprot id: A0A8J1MX92
uniprot id: A0A8J1MY58
uniprot id: A0A8J1MYP8
uniprot id: A0A8J1MZG7
uniprot id: A0A8J1MZH2
uniprot id: A0A974HNV1
names: Similarity
messages: Belongs to the OSBP family.

8355:katnal1.S
gene id: 8355:katnal1.S
uniprot id: A0A1L8HAJ0
uniprot id: A0A974DL13
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
messages: Cytoplasm
messages: Interacts with KATNB1 and KATNBL1.
messages: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

8355:LOC108713153
gene id: 8355:LOC108713153
uniprot id: A0A1L8GUE8
uniprot id: A0A8J0UWN9
uniprot id: A0A974HRM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

8355:vps72.S
gene id: 8355:vps72.S
uniprot id: A0A1L8F4P2
names: Function
names: Similarity
messages: Belongs to the VPS72/YL1 family.
messages: Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.

8355:LOC108710284
gene id: 8355:LOC108710284
uniprot id: A0A1L8GZV3
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

8355:sema4a.S
gene id: 8355:sema4a.S
uniprot id: A0A1L8F511
uniprot id: A0A8J1LP73
uniprot id: A0A974H6T5
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:smn1.L
gene id: 8355:smn1.L
uniprot id: A0A8J0U155
uniprot id: A0A974E469
uniprot id: Q6NU78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMN family.
messages: Cajal body
messages: Perikaryon
messages: Z line
messages: gem
messages: neuron projection

8355:LOC121395691
gene id: 8355:LOC121395691
uniprot id: A0A8J1LA76
uniprot id: A0A8J1LA81
uniprot id: A0A8J1LB65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8355:eef1g.S
gene id: 8355:eef1g.S
uniprot id: Q91375
names: Function
names: Subunit
messages: EF-1 is composed of four subunits: alpha, beta, delta, and gamma.
messages: Probably plays a role in anchoring the complex to other cellular components.

8355:tjp3.S
gene id: 8355:tjp3.S
uniprot id: A0A974DSR3
uniprot id: Q7ZTN1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

8355:cyria.L
gene id: 8355:cyria.L
uniprot id: A0A1L8GBL6
uniprot id: A0A8J0V9K4
uniprot id: A0A974HKL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYRI family.
messages: Membrane

8355:cenpa.L
gene id: 8355:cenpa.L
uniprot id: A0A974C7E7
uniprot id: Q569M3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H3 family.
messages: Component of centromeric nucleosomes, where DNA is wrapped around a histone octamer core. The octamer contains two molecules each of H2A, H2B, CENPA and H4 assembled in one CENPA-H4 heterotetramer and two H2A-H2B heterodimers. CENPA modulates the DNA-binding characteristics of nucleosomes so that protruding DNA ends have higher flexibility than in nucleosomes containing conventional histone H3.
messages: Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis.
messages: Nucleus
messages: centromere

8355:lmx1a.S
gene id: 8355:lmx1a.S
uniprot id: A0A1L8GGE2
uniprot id: A0A974HMD3
names: Subcellular Location Annotation
messages: Nucleus

8355:tnfaip6.L
gene id: 8355:tnfaip6.L
uniprot id: A0A974BZ22
uniprot id: Q5I051
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108710079
gene id: 8355:LOC108710079
uniprot id: A0A8J1MFU0
uniprot id: A0A8J1MFU6
uniprot id: A0A8J1MGS1
uniprot id: A0A8J1MHN3
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8355:magt1.L
gene id: 8355:magt1.L
uniprot id: Q63ZR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory component of the STT3B-containing form of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. May be involved in substrate-specific N-glycosylation involving acceptor sites that are near cysteine residues.
messages: Accessory component of the STT3B-containing form of the oligosaccharyltransferase (OST) complex.
messages: Belongs to the OST3/OST6 family.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: May be involved in Mg(2+) transport in epithelial cells.

8355:hdhd2.L
gene id: 8355:hdhd2.L
uniprot id: A0A1L8I2W1
uniprot id: A0A974E3I7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

8355:tmem121.S
gene id: 8355:tmem121.S
uniprot id: A0A8J1LNQ8
names: Similarity
messages: Belongs to the TMEM121 family.

8355:LOC121398782
gene id: 8355:LOC121398782
uniprot id: A0A8J1LWZ3
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:usp2.L
gene id: 8355:usp2.L
uniprot id: A0A1L8FLG3
uniprot id: A0A8J0TBS5
uniprot id: A0A974HC03
names: Similarity
messages: Belongs to the peptidase C19 family.

8355:dio3.L
gene id: 8355:dio3.L
uniprot id: P49899
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iodothyronine deiodinase family.
messages: Cell membrane
messages: Endosome membrane
messages: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). May play a protective role in selected tissues by preventing their exposure to inappropriately timed or excessive levels of thyroid hormone.

8355:gabra1.S
gene id: 8355:gabra1.S
uniprot id: A0A8J1MRH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8355:tbc1d31.L
gene id: 8355:tbc1d31.L
uniprot id: A0A8J0VEY2
uniprot id: Q6DDI6
names: Function
names: Subcellular Location Annotation
messages: Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation.
messages: centriolar satellite
messages: centrosome
messages: cilium basal body

8355:LOC108696263
gene id: 8355:LOC108696263
uniprot id: A0A1L8FK17
uniprot id: A0A8J1L5K1
uniprot id: A0A974CF14
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

8355:LOC108695577
gene id: 8355:LOC108695577
uniprot id: A0A1L8FQ56
uniprot id: A0A974CIX7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:XB5740125.L
gene id: 8355:XB5740125.L
uniprot id: A0A974DYI7
uniprot id: Q5PQ10
names: Subcellular Location Annotation
messages: Membrane

8355:nfxl1.L
gene id: 8355:nfxl1.L
uniprot id: A0A974DZ10
uniprot id: A0JMY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NFX1 family.
messages: Membrane

8355:fto.L
gene id: 8355:fto.L
uniprot id: A0A8J0UYD2
uniprot id: A0A8J0UZL0
uniprot id: A0A8J0V3A7
uniprot id: A0A8J1MTX2
uniprot id: A0A8J1MU51
uniprot id: A0A8J1MVC6
uniprot id: A0A8J1MWA5
uniprot id: Q68F54
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by ascorbate. Inhibited by N-oxalylglycine, fumarate and succinate.
messages: Belongs to the fto family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer. May also exist as homodimer.
messages: Nucleus
messages: Nucleus speckle
messages: RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. M6A demethylation by FTO affects mRNA expression and stability. Also able to demethylate m6A in U6 small nuclear RNA (snRNA). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA. Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping. Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs.
messages: The 3D-structure of the Fe2OG dioxygenase domain is similar to that of the Fe2OG dioxygenase domain found in the bacterial DNA repair dioxygenase alkB and its mammalian orthologs, but sequence similarity is very low. As a consequence, the domain is not detected by protein signature databases.

8355:prss1.L
gene id: 8355:prss1.L
uniprot id: P70059
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: extracellular space

8355:lix1l.L
gene id: 8355:lix1l.L
uniprot id: A0A8J1LJI5
names: Similarity
messages: Belongs to the LIX1 family.

8355:LOC121397550
gene id: 8355:LOC121397550
uniprot id: A0A8J1LM82
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

8355:LOC121399799
gene id: 8355:LOC121399799
uniprot id: A0A8J1M6Q2
names: Similarity
messages: Belongs to the CD200R family.

8355:glra3.L
gene id: 8355:glra3.L
uniprot id: A0A1L8HU47
uniprot id: A0A974I2U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

8355:LOC108712776
gene id: 8355:LOC108712776
uniprot id: A0A1L8GS57
uniprot id: A0A974D7N7
names: Subcellular Location Annotation
messages: Membrane

8355:mad1l1.L
gene id: 8355:mad1l1.L
uniprot id: A0A8J1LPI8
uniprot id: A0A8J1LQR5
uniprot id: A0A8J1LRU7
uniprot id: A0A974C0B7
uniprot id: Q6GPD1
names: Similarity
messages: Belongs to the MAD1 family.

8355:LOC108701220
gene id: 8355:LOC108701220
uniprot id: A0A1L8EV25
uniprot id: A0A8J0TUD8
uniprot id: A0A974BY86
names: Subcellular Location Annotation
messages: Cytoplasm

8355:zar1.S
gene id: 8355:zar1.S
uniprot id: Q7T3U0
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ZAR1 family.
messages: Cytoplasmic ribonucleoprotein granule
messages: Disordered regions undergo liquid-liquid phase separation (LLPS) for the formation of membraneless compartments that store maternal mRNAs in oocytes.
messages: Expressed during oocyte maturation: reaches maximum levels at stages I-III and then declined through stages IV to VI (PubMed:23827238). During oocyte maturation, levels remain constant (PubMed:23827238).
messages: Ovary (PubMed:12773403, PubMed:23827238). Also expressed in lung and muscle (PubMed:12773403).
messages: The 3CxxC-type mediates binding to the 3'-UTR of mRNAs.
messages: mRNA-binding protein required for maternal mRNA storage, translation and degradation during oocyte maturation (PubMed:23827238). Probably promotes formation of some phase-separated membraneless compartment that stores maternal mRNAs in oocytes: acts by undergoing liquid-liquid phase separation upon binding to maternal mRNAs (By similarity). Binds to the 3'-UTR of maternal mRNAs in immature oocytes, inhibiting their translation (PubMed:23827238).

8355:LOC108705945
gene id: 8355:LOC108705945
uniprot id: A0A8J1M652
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:triap1.S
gene id: 8355:triap1.S
uniprot id: A0A974DVG7
uniprot id: Q6INR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIAP1/MDM35 family.
messages: Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. The triap1:prelid1 complex probably functions as a phosphatidic acid (PA) transporter across the mitochondrion intermembrane space to provide PA for cardiolipin CL synthesis in the inner membrane. Likewise, the triap1:prelid3a complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (By similarity). Required for pronephros development; probably involved at an early stage in the formation of pronephric components derived from the somatic layer (By similarity).
messages: Mitochondrion
messages: Mitochondrion intermembrane space
messages: Monomer. Forms a complex with prelid1 in the mitochondrion intermembrane space. Interacts with prelid3a.

8355:adgra2.L
gene id: 8355:adgra2.L
uniprot id: Q6P4S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

8355:nsg2.S
gene id: 8355:nsg2.S
uniprot id: A0A974DB78
uniprot id: Q52L09
names: Similarity
messages: Belongs to the NSG family.

8355:LOC108713211
gene id: 8355:LOC108713211
uniprot id: A0A1L8GUT6
uniprot id: A0A8J1MT20
uniprot id: A0A974HR88
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

8355:spg7.L
gene id: 8355:spg7.L
uniprot id: A0A8J0U646
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

8355:apom.L
gene id: 8355:apom.L
uniprot id: A0A8J0THH6
uniprot id: A0A8J0TKV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
messages: Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.
messages: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
messages: Secreted

8355:cyp4v2.1.L
gene id: 8355:cyp4v2.1.L
uniprot id: Q6GMD7
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:naxd.S
gene id: 8355:naxd.S
uniprot id: A0A8J0UD78
uniprot id: A0A8J0ULA1
uniprot id: A0A8J0UP38
names: Function
names: Similarity
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.

8355:ube2a.L
gene id: 8355:ube2a.L
uniprot id: A0A1L8F7M5
uniprot id: A0A974C6G0
uniprot id: A0A974H5S8
uniprot id: Q6PB14
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8355:foxa4.S
gene id: 8355:foxa4.S
uniprot id: P33206
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: By activin. Down-regulated indirectly by bmp-4 signaling, mediated via vent1.
messages: First expressed shortly after the mid blastula transition. Most abundant during gastrulation (stages 10 and 12).
messages: Nucleus
messages: Primarily expressed in the dorsal blastopore lip (Spemann organizer) of early gastrulae. At later stages, expressed in the dorsal mesoderm and the neural floor plate. In the dorsal mesoderm, expressed in the notochord but not in the presomitic mesoderm. Also expressed in the mid-brain area.
messages: Transcriptional repressor involved in embryonic nervous system development. Plays a role in the induction and patterning of the anterior-posterior neural axis. Involved in the establishment of floor plate differentiation from neural plate cells during gastrulation. Binds the anf1 promoter sequence to restrict expression of anf1 to the anterior of the neural plate, thereby patterning the forebrain. Can bind to the HNF-3-alpha DNA target sequence. Cooperates with t/bra in a dose-dependent manner to specify dorsal mesoderm formation, including notochord. May be involved in the dorso-ventral patterning of the mesoderm. Binds to DNA via the target sequence 5'-[GA]TAAA[TC]A-3', with 5'-GTAAATA-3' being the preferred binding site (By similarity).

8355:cct6a.L
gene id: 8355:cct6a.L
uniprot id: A0A1L8HG76
uniprot id: A0A974HYF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

8355:XB5899916.L
gene id: 8355:XB5899916.L
uniprot id: A0A1L8H396
uniprot id: A0A974DG76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

8355:LOC494799
gene id: 8355:LOC494799
uniprot id: A0A1L8GN17
uniprot id: A0A974HPA9
uniprot id: Q63ZI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

8355:gtf2a1.L
gene id: 8355:gtf2a1.L
uniprot id: A0A8J1LFU2
uniprot id: A0A8J1LGT3
uniprot id: Q6XPY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

8355:cdc6.L
gene id: 8355:cdc6.L
uniprot id: Q6IP89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
messages: Nucleus

8355:ublcp1.S
gene id: 8355:ublcp1.S
uniprot id: A0A974HQ78
uniprot id: Q641F1
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. Recruited to the 19S regulatory particle of the 26S proteasome where it dephosphorylates 19S component psmc2 which impairs psmc2 ATPase activity and disrupts 26S proteasome assembly. Has also been reported to stimulate the proteolytic activity of the 26S proteasome.
messages: Nucleus
messages: The Ubiquitin-like domain mediates interaction with proteasomes.

8355:clca1.1.L
gene id: 8355:clca1.1.L
uniprot id: A0A8J0UYW8
names: Similarity
messages: Belongs to the CLCR family.

8355:scamp1.S
gene id: 8355:scamp1.S
uniprot id: A0A1L8HRG4
uniprot id: A0A974DVG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

8355:mfn2.L
gene id: 8355:mfn2.L
uniprot id: A0A974HBW7
uniprot id: Q6NRV9
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

8355:med18.L
gene id: 8355:med18.L
uniprot id: A0A1L8HEA0
uniprot id: A0A974DM43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8355:LOC108704663
gene id: 8355:LOC108704663
uniprot id: A0A8J0U5A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

8355:LOC121398264
gene id: 8355:LOC121398264
uniprot id: A0A8J1LUC1
names: Similarity
messages: Belongs to the HARBI1 family.

8355:LOC108708008
gene id: 8355:LOC108708008
uniprot id: A0A1L8HDN3
uniprot id: A0A974DNV9
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

8355:cyp2a6.2.S
gene id: 8355:cyp2a6.2.S
uniprot id: A0A1L8F3W7
uniprot id: A0A974C4D2
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:lrwd1.L
gene id: 8355:lrwd1.L
uniprot id: Q6GM71
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LRWD1 family.
messages: Component of the ORC complex.
messages: Nucleus
messages: Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability (By similarity).
messages: The entire WD repeat region is required for the interaction with ORC complex components, as well as for association with chromatin and for binding to histone methylation marks.
messages: centromere
messages: centrosome
messages: kinetochore
messages: telomere

8355:LOC108704466
gene id: 8355:LOC108704466
uniprot id: A0A8J1LHL2
uniprot id: A0A8J1LHL7
uniprot id: A0A8J1LHP6
uniprot id: A0A8J1LHQ4
uniprot id: A0A8J1LI82
uniprot id: A0A8J1LI89
uniprot id: A0A8J1LIZ5
uniprot id: A0A8J1LJ01
uniprot id: A0A8J1LJ08
uniprot id: A0A8J1LK28
uniprot id: A0A8J1LK34
uniprot id: A0A8J1LK40
names: Similarity
messages: Belongs to the UPL family. TOM1/PTR1 subfamily.

8355:bcl2l1.S
gene id: 8355:bcl2l1.S
uniprot id: A0A974H0V0
uniprot id: Q90ZH2
names: Similarity
messages: Belongs to the Bcl-2 family.

8355:LOC108708637
gene id: 8355:LOC108708637
uniprot id: A0A1L8HIE5
uniprot id: A0A974HZK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

8355:cox20.L
gene id: 8355:cox20.L
uniprot id: A0A974HJK8
uniprot id: Q569S6
names: Similarity
messages: Belongs to the COX20 family.

8355:MGC146443.L
gene id: 8355:MGC146443.L
uniprot id: Q58E11
names: Similarity
messages: Belongs to the RNase H family.

8355:krt8.2.L
gene id: 8355:krt8.2.L
uniprot id: A0A1L8EVH5
uniprot id: A0A974BZD9
names: Similarity
messages: Belongs to the intermediate filament family.

8355:LOC108719485
gene id: 8355:LOC108719485
uniprot id: A0A1L8HST2
uniprot id: A0A974DW13
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:arhgdib.S
gene id: 8355:arhgdib.S
uniprot id: A0A974D0C6
uniprot id: Q7SZS9
names: Similarity
messages: Belongs to the Rho GDI family.

8355:LOC108705347
gene id: 8355:LOC108705347
uniprot id: A0A8J0U9H8
names: Similarity
messages: Belongs to the MCM family.

8355:cyp7a1.S
gene id: 8355:cyp7a1.S
uniprot id: A0A8J0T6Z6
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:atg9b.L
gene id: 8355:atg9b.L
uniprot id: A0A8J0U7Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

8355:hal.1.L
gene id: 8355:hal.1.L
uniprot id: A0A8J0UNK0
uniprot id: A0A8J1MH56
uniprot id: A0A8J1MHR5
uniprot id: Q6AZU6
names: Similarity
messages: Belongs to the PAL/histidase family.

8355:LOC121399723
gene id: 8355:LOC121399723
uniprot id: A0A1L8HF99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:nrp1.L
gene id: 8355:nrp1.L
uniprot id: Q5XH75
names: Caution
names: Similarity
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:tmem121.L
gene id: 8355:tmem121.L
uniprot id: A0A1L8FB36
uniprot id: A0A974H8Q4
names: Similarity
messages: Belongs to the TMEM121 family.

8355:txnrd2.S
gene id: 8355:txnrd2.S
uniprot id: Q7T0L5
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

8355:LOC108695657
gene id: 8355:LOC108695657
uniprot id: A0A8J0SZE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:znrf3.L
gene id: 8355:znrf3.L
uniprot id: A0A1L8I1K4
uniprot id: A0A974E2K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZNRF3 family.
messages: Cell membrane

8355:svopl.S
gene id: 8355:svopl.S
uniprot id: A0A8J1MUC1
names: Subcellular Location Annotation
messages: Membrane

8355:aimp2.S
gene id: 8355:aimp2.S
uniprot id: A0A974BV74
uniprot id: Q6INU4
names: Subcellular Location Annotation
messages: Nucleus
messages: cytosol

8355:gmds.L
gene id: 8355:gmds.L
uniprot id: Q8AVI1
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.

8355:trim67.S
gene id: 8355:trim67.S
uniprot id: A0A1L8G232
uniprot id: A0A8J0VC37
uniprot id: A0A8J0VF74
uniprot id: A0A8J0VG67
uniprot id: A0A974CSL5
names: Subcellular Location Annotation
messages: cytoskeleton

8355:rab3c.S
gene id: 8355:rab3c.S
uniprot id: A0A8J0U7F1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

8355:btrc.S
gene id: 8355:btrc.S
uniprot id: Q91854
names: Developmental Stage
names: Function
names: Subunit
messages: Part of a SCF (SKP1-cullin-F-box) ubiquitin-protein ligase complex. Interacts with fbxo5 (PubMed:17159919).
messages: Present in fully grown and progesterone-matured oocytes. The level change very little even after zygotic gene transcription begins following the midblastula transition. Do not increase in abundance in the gastrula, neurula, tailbud, or tadpole embryo.
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. May participate in Wnt signaling.

8355:LOC108696132
gene id: 8355:LOC108696132
uniprot id: A0A1L8FJ80
uniprot id: A0A8J1L4W0
uniprot id: A0A8J1L4Y3
uniprot id: A0A974CF75
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108713484
gene id: 8355:LOC108713484
uniprot id: A0A8J1MVX4
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.

8355:LOC108695855
gene id: 8355:LOC108695855
uniprot id: A0A1L8FMA8
uniprot id: A0A974CG06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:crygdl.5.S
gene id: 8355:crygdl.5.S
uniprot id: A0A1L8HNK8
uniprot id: A0A974DUH1
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:hmgb2.S
gene id: 8355:hmgb2.S
uniprot id: A0A974DTJ1
uniprot id: Q32NS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

8355:b3gnt5.L
gene id: 8355:b3gnt5.L
uniprot id: A0A974HKC1
uniprot id: Q5HZL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids.
messages: Golgi apparatus membrane
messages: Membrane

8355:spag9.S
gene id: 8355:spag9.S
uniprot id: A0A1L8ENA0
uniprot id: A0A8J0TZW1
uniprot id: A0A974BTM1
names: Similarity
messages: Belongs to the JIP scaffold family.

8355:LOC108710293
gene id: 8355:LOC108710293
uniprot id: A0A1L8H068
uniprot id: A0A974DDP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane

8355:zbtb8a.1.L
gene id: 8355:zbtb8a.1.L
uniprot id: Q0IH98
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

8355:fnta.S
gene id: 8355:fnta.S
uniprot id: A9ULW7
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

8355:tsnax.S
gene id: 8355:tsnax.S
uniprot id: A0A974HHE6
uniprot id: Q7SZ15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the translin family.
messages: Nucleus

8355:LOC108715881
gene id: 8355:LOC108715881
uniprot id: A0A8J0V7C2
uniprot id: A0A8J1KK28
uniprot id: A0A8J1KLR3
uniprot id: A0A8J1KN52
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor that may have an important role in cell/cell signaling during nervous system formation.

8355:LOC100301952
gene id: 8355:LOC100301952
uniprot id: A0A8J1MBX4
uniprot id: A0A8J1MCV5
uniprot id: A0A974DYE5
uniprot id: B7ZRC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

8355:efhc2.L
gene id: 8355:efhc2.L
uniprot id: A0A1L8HF70
uniprot id: A0A8J0U6T2
uniprot id: A0A974HY91
names: Subcellular Location Annotation
messages: cilium axoneme

8355:ctsk.L
gene id: 8355:ctsk.L
uniprot id: A0A974CAJ0
uniprot id: A8WH59
names: Similarity
messages: Belongs to the peptidase C1 family.

8355:cops6.S
gene id: 8355:cops6.S
uniprot id: A0A8J1MNZ7
uniprot id: A0A8J1MQ33
uniprot id: Q6NUC2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although related to the peptidase M67A family, it lacks the JAMM motif that probably constitutes the catalytic center and therefore it probably does not have a protease activity.
messages: Belongs to the peptidase M67A family. CSN6 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity).
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.
messages: Component of the CSN complex, probably composed of cops1, cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
messages: Cytoplasm
messages: Nucleus

8355:MGC82022
gene id: 8355:MGC82022
uniprot id: Q6GM90
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:psmd7.L
gene id: 8355:psmd7.L
uniprot id: A0A974D580
uniprot id: Q66IY6
names: Similarity
messages: Belongs to the peptidase M67A family.

8355:LOC121399914
gene id: 8355:LOC121399914
uniprot id: A0A8J1M7Y9
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:mtmr12.L
gene id: 8355:mtmr12.L
uniprot id: A0A1L8I2N1
uniprot id: A0A974E3K2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

8355:LOC108709103
gene id: 8355:LOC108709103
uniprot id: A0A1L8H6V5
uniprot id: A0A974DH07
names: Similarity
messages: Belongs to the peptidase A1 family.

8355:polr2i.L
gene id: 8355:polr2i.L
uniprot id: A0A1L8F868
uniprot id: A0A1L8F869
uniprot id: A0A974C716
uniprot id: A0A974C757
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

8355:LOC108701294
gene id: 8355:LOC108701294
uniprot id: A0A8J0TVV6
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:tspan33.S
gene id: 8355:tspan33.S
uniprot id: A0A1L8GTL4
uniprot id: A0A8J1MRE5
uniprot id: A0A974DAK7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:eif3l.S
gene id: 8355:eif3l.S
uniprot id: A0A1L8GH36
uniprot id: A0A8J0V7Q3
uniprot id: A0A8J1KJT2
uniprot id: A0A974D2F1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit L family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

8355:actr2.L
gene id: 8355:actr2.L
uniprot id: A0A974HJ32
uniprot id: Q7ZXV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).
messages: Belongs to the actin family.
messages: Belongs to the actin family. ARP2 subfamily.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of actr2/arp2, actr3/arp3, arpc1 (arpc1a or arpc1b), arpc2, arpc3, arpc4 and arpc5.
messages: Nucleus
messages: cytoskeleton

8355:camsap2.S
gene id: 8355:camsap2.S
uniprot id: A0A1L8GGK7
uniprot id: A0A8J0V6N5
uniprot id: A0A974HLX2
names: Domain
names: Similarity
messages: Belongs to the CAMSAP1 family.
messages: The CKK domain binds microtubules.

8355:map4.L
gene id: 8355:map4.L
uniprot id: A0A8J0VEJ6
uniprot id: A0A8J0VH97
uniprot id: A0A8J0VIG5
uniprot id: A0A8J0VMN2
uniprot id: A0A8J0VMN7
uniprot id: A0A8J1KVE7
uniprot id: A0A8J1KVF2
uniprot id: A0A8J1KVF3
uniprot id: A0A8J1KWY3
uniprot id: A0A8J1KWY9
uniprot id: A0A8J1KYD9
uniprot id: A0A8J1KYE5
uniprot id: Q9YI90
names: Subcellular Location Annotation
messages: cytoskeleton

8355:ocm4.5.S
gene id: 8355:ocm4.5.S
uniprot id: A0A974BVJ1
uniprot id: Q7ZY39
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

8355:LOC108708762
gene id: 8355:LOC108708762
uniprot id: A0A8J1MAN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

8355:polr1c.L
gene id: 8355:polr1c.L
uniprot id: A0A8J1KPF8
uniprot id: A0A974CVK0
uniprot id: Q6IP84
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

8355:akr1c2.L
gene id: 8355:akr1c2.L
uniprot id: Q7ZXN5
names: Similarity
messages: Belongs to the aldo/keto reductase family.

8355:LOC121397121
gene id: 8355:LOC121397121
uniprot id: A0A8J1LI13
uniprot id: A0A8J1LI49
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

8355:LOC108702440
gene id: 8355:LOC108702440
uniprot id: A0A8J0TYG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8355:LOC108700556
gene id: 8355:LOC108700556
uniprot id: A0A8J1LNB2
names: Similarity
messages: Belongs to the MAP7 family.

8355:LOC108718228
gene id: 8355:LOC108718228
uniprot id: A0A1L8G527
uniprot id: A0A8J1KUH1
uniprot id: A0A8J1KUH4
uniprot id: A0A8J1KUH6
uniprot id: A0A8J1KUI3
uniprot id: A0A8J1KUI5
uniprot id: A0A8J1KUI8
uniprot id: A0A8J1KW25
uniprot id: A0A8J1KW30
uniprot id: A0A8J1KW35
uniprot id: A0A8J1KXJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

8355:ppib.L
gene id: 8355:ppib.L
uniprot id: A0A974HTG1
uniprot id: Q7SZ26
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

8355:med22.S
gene id: 8355:med22.S
uniprot id: A0A1L8F180
uniprot id: A0A8J0TG39
uniprot id: A0A8J0TML0
uniprot id: A0A8J1LQK3
uniprot id: A0A974C2R9
names: Function
names: Subcellular Location Annotation
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

8355:LOC108698121
gene id: 8355:LOC108698121
uniprot id: A0A8J0TI98
names: Similarity
messages: Belongs to the Bcl-2 family.

8355:ywhae.L
gene id: 8355:ywhae.L
uniprot id: A0A8J0UGW4
uniprot id: A0A8J1MB40
names: Function
names: Similarity
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
messages: Belongs to the 14-3-3 family.

8355:slc13a1.S
gene id: 8355:slc13a1.S
uniprot id: A0A8J1MSN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

8355:ppp1cb.L
gene id: 8355:ppp1cb.L
uniprot id: A0A974CPW5
uniprot id: Q6GQL2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Nucleus
messages: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity (By similarity).

8355:LOC108716473
gene id: 8355:LOC108716473
uniprot id: A0A8J1KMD0
uniprot id: A0A8J1KME3
uniprot id: A0A8J1KP39
uniprot id: A0A8J1KQI7
names: Similarity
messages: Belongs to the BROX family.

8355:mlh3.L
gene id: 8355:mlh3.L
uniprot id: A0A1L8F9E2
uniprot id: A0A8J0PX07
uniprot id: A0A8J0TGL1
uniprot id: A0A8J0THG9
uniprot id: A0A974C842
uniprot id: Q6GNZ4
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

8355:parp12.L
gene id: 8355:parp12.L
uniprot id: A0A8J0U755
names: Similarity
messages: Belongs to the ARTD/PARP family.

8355:ap2m1.S
gene id: 8355:ap2m1.S
uniprot id: A0A974CRP1
uniprot id: Q801Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit and beta-type subunit), a medium adaptin (mu-type subunit) and a small adaptin (sigma-type subunit).
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositide-containing lipids.
messages: coated pit

8355:otub2.S
gene id: 8355:otub2.S
uniprot id: Q5U588
names: Similarity
messages: Belongs to the peptidase C65 family.

8355:slc25a38.S
gene id: 8355:slc25a38.S
uniprot id: A0A8J1KJN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Membrane
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.
messages: Mitochondrion inner membrane

8355:sart1.S
gene id: 8355:sart1.S
uniprot id: A0A974HL53
uniprot id: Q7ZYC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNU66/SART1 family.
messages: Nucleus

8355:tmem30a.L
gene id: 8355:tmem30a.L
uniprot id: Q7ZXD1
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

8355:LOC108711267
gene id: 8355:LOC108711267
uniprot id: A0A1L8GZS5
uniprot id: A0A974HSZ3
names: Similarity
messages: Belongs to the TCAF family.

8355:fgf20.S
gene id: 8355:fgf20.S
uniprot id: A0A1L8HLD0
uniprot id: A0A974DTR1
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

8355:hbe1.L
gene id: 8355:hbe1.L
uniprot id: A0A974BZX1
uniprot id: Q66KY4
names: Similarity
messages: Belongs to the globin family.

8355:copb2.S
gene id: 8355:copb2.S
uniprot id: Q7ZTR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat COPB2 family.
messages: COPI-coated vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
messages: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner.

8355:polr1e.L
gene id: 8355:polr1e.L
uniprot id: A0A974E0B6
uniprot id: Q6GLI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF.
messages: nucleolus

8355:LOC121397070
gene id: 8355:LOC121397070
uniprot id: A0A1L8F9D9
uniprot id: A0A8J1LJR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Stoned B family.
messages: Cytoplasm

8355:st8sia4.L
gene id: 8355:st8sia4.L
uniprot id: A0A1L8I1M0
uniprot id: A0A974E2H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8355:gcnt3.L
gene id: 8355:gcnt3.L
uniprot id: A0A974DES7
uniprot id: Q5U258
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 14 family.
messages: Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans.
messages: Golgi apparatus membrane
messages: Membrane

8355:timp3.L
gene id: 8355:timp3.L
uniprot id: A0A8J1MKB9
names: Similarity
messages: Belongs to the protease inhibitor I35 (TIMP) family.

8355:s100a10.L
gene id: 8355:s100a10.L
uniprot id: P27004
uniprot id: Q66KZ2
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.
messages: Because p10 induces the dimerization of annexin II (p36), it may function as a regulator of protein phosphorylation in that the p36 monomer is the preferred target (in vitro) of tyrosine-specific kinase.
messages: Belongs to the S-100 family.
messages: Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.
messages: Tetramer of 2 light chains (p10) and 2 heavy chains (annexin II).

8355:ro60.L
gene id: 8355:ro60.L
uniprot id: A0A1L8GNJ3
uniprot id: A0A974HPG1
uniprot id: B7ZQ38
uniprot id: P42700
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ro 60 kDa family.
messages: Cytoplasm
messages: RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs (PubMed:15907467, PubMed:17041599). May play roles in cilia formation and/or maintenance (By similarity).
messages: The MIDAS-like motif in the VWFA-like domain binds divalent metal cations.
messages: The horseshoe-shaped TROVE domain is built with 7 helical HEAT-like repeats, and is closed by the VWFA-like domain giving rise to a ring-shaped monomer. Single-stranded RNA is bound in the positively charged central cavity.

8355:ggact.L
gene id: 8355:ggact.L
uniprot id: Q66KX0
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: May contribute to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine.

8355:acad8.L
gene id: 8355:acad8.L
uniprot id: A0A8J0SYX9
uniprot id: A0A974HC91
uniprot id: Q6PGS8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

8355:pnkd.S
gene id: 8355:pnkd.S
uniprot id: A0A1L8ENV1
uniprot id: A0A974BUQ3
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

8355:clns1a.S
gene id: 8355:clns1a.S
uniprot id: A0A1L8HB32
uniprot id: A0A974HWV2
uniprot id: A0A974HWZ3
uniprot id: P54106
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pICln (TC 1.A.47) family.
messages: Component of the methylosome, a 20S complex containing at least clns1a/picln, prmt5/skb1 and wdr77/mep50; may mediate snrpd1 and snrpd3 methylation. Forms a 6S pICln-Sm complex composed of clns1a/picln, snrpd1, snrpd2, snrpe, snrpf and snrpg; ring-like structure where clns1a/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP.
messages: Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (By similarity). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (By similarity). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (By similarity). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (By similarity). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity).
messages: Nucleus
messages: cytoskeleton
messages: cytosol

8355:stbd1.L
gene id: 8355:stbd1.L
uniprot id: A0A1L8HVI6
uniprot id: A0A974I3I9
names: Similarity
messages: Belongs to the FAM47 family.

8355:osr1.L
gene id: 8355:osr1.L
uniprot id: P86413
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: At early gastrula stage, expressed in the involuting mesoderm and endoderm. During neurulation, expressed in the pronephric primordium, following expression of osr2. During tailbud (stage 35), expressed in the rectal diverticulum and in the kidney ducts.
messages: Belongs to the Odd C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Transcriptional repressor. Required for pronephric kidney development.

8355:LOC108708760
gene id: 8355:LOC108708760
uniprot id: A0A8J1MAC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Membrane

8355:usp36.S
gene id: 8355:usp36.S
uniprot id: A0A8J0TZH0
uniprot id: A0A8J0U0N9
uniprot id: A0A8J0U2G2
names: Similarity
messages: Belongs to the peptidase C19 family.

8355:c3orf70.L
gene id: 8355:c3orf70.L
uniprot id: A0A1L8EWR6
uniprot id: A0A8J0TXZ3
uniprot id: A0A974H3Q1
names: Similarity
messages: Belongs to the UPF0524 family.

8355:LOC108697910
gene id: 8355:LOC108697910
uniprot id: A0A1L8FDR1
uniprot id: A0A974CB89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

8355:add2.S
gene id: 8355:add2.S
uniprot id: A0A1L8GS59
uniprot id: A0A1L8GS92
uniprot id: A0A974D6W4
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

8355:anxa13.S
gene id: 8355:anxa13.S
uniprot id: A0A1L8FTY3
uniprot id: A0A974HEJ7
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

8355:LOC108696733
gene id: 8355:LOC108696733
uniprot id: A0A1L8FNC7
uniprot id: A0A8J0TBS2
uniprot id: A0A974CGR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.