827:CURT RS00535
gene id: 827:CURT_RS00535
uniprot id: A0A2I1NA17
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

827:CURT RS00215
gene id: 827:CURT_RS00215
uniprot id: A0A381EE70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

827:CURT RS04375
gene id: 827:CURT_RS04375
uniprot id: A0A381E8S9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

827:CURT RS02080
gene id: 827:CURT_RS02080
uniprot id: A0A381EBL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

827:CURT RS00080
gene id: 827:CURT_RS00080
uniprot id: A0A381EEB2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

827:CURT RS07565
gene id: 827:CURT_RS07565
uniprot id: A0A381E3K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

827:CURT RS02535
gene id: 827:CURT_RS02535
uniprot id: A0A381EB34
names: Similarity
messages: Belongs to the class-I fumarase family.

827:CURT RS00075
gene id: 827:CURT_RS00075
uniprot id: A0A2I1N9N9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

827:CURT RS03985
gene id: 827:CURT_RS03985
uniprot id: A0A381E9J3
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

827:CURT RS07890
gene id: 827:CURT_RS07890
uniprot id: A0A381E301
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

827:CURT RS00995
gene id: 827:CURT_RS00995
uniprot id: A0A381ED85
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS01805
gene id: 827:CURT_RS01805
uniprot id: A0A2I1NC86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

827:CURT RS09160
gene id: 827:CURT_RS09160
uniprot id: A0A381EEE9
names: Similarity
messages: Belongs to the UPF0102 family.

827:CURT RS00645
gene id: 827:CURT_RS00645
uniprot id: A0A381EDD9
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

827:CURT RS09270
gene id: 827:CURT_RS09270
uniprot id: A0A381EEE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

827:CURT RS04670
gene id: 827:CURT_RS04670
uniprot id: A0A381E856
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

827:CURT RS07560
gene id: 827:CURT_RS07560
uniprot id: A0A2I1NAN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane

827:CURT RS03200
gene id: 827:CURT_RS03200
uniprot id: A0A381EAG7
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS01560
gene id: 827:CURT_RS01560
uniprot id: A0A381ECI4
names: Similarity
messages: Belongs to the pyruvate kinase family.

827:CURT RS03610
gene id: 827:CURT_RS03610
uniprot id: A0A381E9Y6
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

827:CURT RS01580
gene id: 827:CURT_RS01580
uniprot id: A0A381ECE1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

827:CURT RS00575
gene id: 827:CURT_RS00575
uniprot id: A0A2I1N9Z1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

827:CURT RS04470
gene id: 827:CURT_RS04470
uniprot id: A0A381E8H4
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.
messages: Catalytic subunit of the nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
messages: Component of the nitrate reductase NapAB complex composed of NapA and NapB.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.
messages: Secreted

827:CURT RS01420
gene id: 827:CURT_RS01420
uniprot id: A0A381ECK7
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS05955
gene id: 827:CURT_RS05955
uniprot id: A0A381E5W2
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

827:CURT RS01220
gene id: 827:CURT_RS01220
uniprot id: A0A381ECY5
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS04285
gene id: 827:CURT_RS04285
uniprot id: A0A381E957
names: Similarity
messages: Belongs to the phosphohexose mutase family.

827:CURT RS08890
gene id: 827:CURT_RS08890
uniprot id: A0A381EET9
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

827:CURT RS06680
gene id: 827:CURT_RS06680
uniprot id: A0A381E4S6
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS02545
gene id: 827:CURT_RS02545
uniprot id: A0A381EB45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.
messages: Membrane

827:CURT RS03115
gene id: 827:CURT_RS03115
uniprot id: A0A381EAT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

827:CURT RS02895
gene id: 827:CURT_RS02895
uniprot id: A0A381EBB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Cell inner membrane
messages: Membrane

827:CURT RS09060
gene id: 827:CURT_RS09060
uniprot id: A0A381EEY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

827:CURT RS03870
gene id: 827:CURT_RS03870
uniprot id: A0A381E9X7
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS08955
gene id: 827:CURT_RS08955
uniprot id: A0A381EEM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

827:CURT RS01225
gene id: 827:CURT_RS01225
uniprot id: A0A381ECQ6
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS04615
gene id: 827:CURT_RS04615
uniprot id: A0A381E8S4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

827:CURT RS05870
gene id: 827:CURT_RS05870
uniprot id: A0A2I1NBI1
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

827:CURT RS08395
gene id: 827:CURT_RS08395
uniprot id: A0A381E1H1
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

827:CURT RS07845
gene id: 827:CURT_RS07845
uniprot id: A0A381E308
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes.
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Homodimer.

827:CURT RS06655
gene id: 827:CURT_RS06655
uniprot id: A0A381E4U0
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

827:CURT RS08160
gene id: 827:CURT_RS08160
uniprot id: A0A381E1T1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

827:CURT RS06070
gene id: 827:CURT_RS06070
uniprot id: A0A381E681
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

827:CURT RS01265
gene id: 827:CURT_RS01265
uniprot id: A0A2I1NBZ0
names: Similarity
messages: Belongs to the UPF0423 family.

827:CURT RS03175
gene id: 827:CURT_RS03175
uniprot id: A0A381EAD8
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.

827:CURT RS00710
gene id: 827:CURT_RS00710
uniprot id: A0A381EE19
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

827:CURT RS05865
gene id: 827:CURT_RS05865
uniprot id: A0A381E6I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

827:CURT RS00605
gene id: 827:CURT_RS00605
uniprot id: A0A381EDK9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

827:CURT RS00205
gene id: 827:CURT_RS00205
uniprot id: A0A381EE21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

827:CURT RS06820
gene id: 827:CURT_RS06820
uniprot id: A0A381E4S4
names: Similarity
messages: Belongs to the UDPGP type 2 family.

827:CURT RS08400
gene id: 827:CURT_RS08400
uniprot id: A0A381E1S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

827:CURT RS07760
gene id: 827:CURT_RS07760
uniprot id: A0A381E376
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

827:CURT RS05025
gene id: 827:CURT_RS05025
uniprot id: A0A381E817
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

827:CURT RS00980
gene id: 827:CURT_RS00980
uniprot id: A0A376C1F4
names: Similarity
messages: Belongs to the citrate synthase family.

827:CURT RS08905
gene id: 827:CURT_RS08905
uniprot id: A0A381EF03
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

827:CURT RS04875
gene id: 827:CURT_RS04875
uniprot id: A0A381E7V5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS05945
gene id: 827:CURT_RS05945
uniprot id: A0A381E676
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.

827:CURT RS08805
gene id: 827:CURT_RS08805
uniprot id: A0A381EES5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

827:CURT RS07580
gene id: 827:CURT_RS07580
uniprot id: A0A381E356
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS06950
gene id: 827:CURT_RS06950
uniprot id: A0A381E4K9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnC family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).

827:CURT RS04225
gene id: 827:CURT_RS04225
uniprot id: A0A381E8V0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

827:CURT RS03015
gene id: 827:CURT_RS03015
uniprot id: A0A381EAY8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

827:CURT RS00815
gene id: 827:CURT_RS00815
uniprot id: A0A381ED84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

827:CURT RS08730
gene id: 827:CURT_RS08730
uniprot id: A0A381EEW6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

827:CURT RS04365
gene id: 827:CURT_RS04365
uniprot id: A0A381E8Y1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

827:CURT RS00795
gene id: 827:CURT_RS00795
uniprot id: A0A381EDG4
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

827:CURT RS04295
gene id: 827:CURT_RS04295
uniprot id: A0A381E8S7
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS01455
gene id: 827:CURT_RS01455
uniprot id: A0A381ECH2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

827:CURT RS04665
gene id: 827:CURT_RS04665
uniprot id: A0A381E8N9
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

827:CURT RS04525
gene id: 827:CURT_RS04525
uniprot id: A0A381E8K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

827:CURT RS02915
gene id: 827:CURT_RS02915
uniprot id: S5TT28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Pal lipoprotein family.
messages: Cell outer membrane

827:CURT RS04475
gene id: 827:CURT_RS04475
uniprot id: A0A381E8F9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

827:CURT RS02620
gene id: 827:CURT_RS02620
uniprot id: A0A381EB12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

827:CURT RS08360
gene id: 827:CURT_RS08360
uniprot id: A0A381E1K7
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

827:CURT RS04620
gene id: 827:CURT_RS04620
uniprot id: A0A381E8D2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

827:CURT RS05765
gene id: 827:CURT_RS05765
uniprot id: A0A381E6K3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS09125
gene id: 827:CURT_RS09125
uniprot id: A0A2I1N8P4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

827:CURT RS00315
gene id: 827:CURT_RS00315
uniprot id: A0A381EDV7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

827:CURT RS05365
gene id: 827:CURT_RS05365
uniprot id: S5TUX1
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

827:CURT RS08235
gene id: 827:CURT_RS08235
uniprot id: A0A381E1T3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

827:CURT RS00120
gene id: 827:CURT_RS00120
uniprot id: A0A381EEJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

827:CURT RS06150
gene id: 827:CURT_RS06150
uniprot id: A0A381E641
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS07930
gene id: 827:CURT_RS07930
uniprot id: A0A381E2E5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

827:CURT RS06830
gene id: 827:CURT_RS06830
uniprot id: A0A381E4W9
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

827:CURT RS06195
gene id: 827:CURT_RS06195
uniprot id: A0A381E601
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

827:CURT RS02015
gene id: 827:CURT_RS02015
uniprot id: A0A381EBQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

827:CURT RS00550
gene id: 827:CURT_RS00550
uniprot id: A0A2I1NA02
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

827:CURT RS00590
gene id: 827:CURT_RS00590
uniprot id: A0A2I1NA00
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

827:CURT RS02500
gene id: 827:CURT_RS02500
uniprot id: A0A381EBI7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

827:CURT RS07745
gene id: 827:CURT_RS07745
uniprot id: A0A381E386
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

827:CURT RS08205
gene id: 827:CURT_RS08205
uniprot id: A0A381E1V4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

827:CURT RS00580
gene id: 827:CURT_RS00580
uniprot id: A0A2I1N9Y8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

827:CURT RS06515
gene id: 827:CURT_RS06515
uniprot id: A0A381E5F8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

827:CURT RS07295
gene id: 827:CURT_RS07295
uniprot id: A0A381E3R4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

827:CURT RS02805
gene id: 827:CURT_RS02805
uniprot id: A0A381EAW1
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

827:CURT RS00990
gene id: 827:CURT_RS00990
uniprot id: A0A381EDG8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

827:CURT RS06470
gene id: 827:CURT_RS06470
uniprot id: A0A381E5I7
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS00505
gene id: 827:CURT_RS00505
uniprot id: A0A2I1NA03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

827:CURT RS08710
gene id: 827:CURT_RS08710
uniprot id: A0A381EEV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

827:CURT RS01400
gene id: 827:CURT_RS01400
uniprot id: A0A381ECG3
names: Similarity
messages: Belongs to the LOG family.

827:CURT RS08165
gene id: 827:CURT_RS08165
uniprot id: A0A381E225
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS01970
gene id: 827:CURT_RS01970
uniprot id: A0A381EC56
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

827:CURT RS01115
gene id: 827:CURT_RS01115
uniprot id: A0A381ED33
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

827:CURT RS01360
gene id: 827:CURT_RS01360
uniprot id: A0A381ECJ2
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS06235
gene id: 827:CURT_RS06235
uniprot id: A0A381E5H0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

827:CURT RS00560
gene id: 827:CURT_RS00560
uniprot id: A0A381EDH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

827:CURT RS08305
gene id: 827:CURT_RS08305
uniprot id: A0A381E1Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

827:CURT RS07230
gene id: 827:CURT_RS07230
uniprot id: A0A2I1NAG8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

827:CURT RS05790
gene id: 827:CURT_RS05790
uniprot id: A0A381E6N0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS02975
gene id: 827:CURT_RS02975
uniprot id: A0A381EAN8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

827:CURT RS06300
gene id: 827:CURT_RS06300
uniprot id: A0A381E5L3
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

827:CURT RS08215
gene id: 827:CURT_RS08215
uniprot id: A0A381E1P1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

827:CURT RS08900
gene id: 827:CURT_RS08900
uniprot id: A0A381EER2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

827:CURT RS04715
gene id: 827:CURT_RS04715
uniprot id: A0A381E8D4
names: Similarity
messages: Belongs to the peptidase A31 family.

827:CURT RS07935
gene id: 827:CURT_RS07935
uniprot id: A0A381E2A8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

827:CURT RS00640
gene id: 827:CURT_RS00640
uniprot id: A0A381EDW0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

827:CURT RS06100
gene id: 827:CURT_RS06100
uniprot id: A0A381E631
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

827:CURT RS00385
gene id: 827:CURT_RS00385
uniprot id: A0A381EDT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

827:CURT RS07190
gene id: 827:CURT_RS07190
uniprot id: A0A381E3R5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

827:CURT RS07185
gene id: 827:CURT_RS07185
uniprot id: A0A381E3W4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

827:CURT RS04485
gene id: 827:CURT_RS04485
uniprot id: A0A381E8L3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

827:CURT RS02365
gene id: 827:CURT_RS02365
uniprot id: A0A381EBA6
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS08040
gene id: 827:CURT_RS08040
uniprot id: A0A381E2G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched chain amino acid transporter family.
messages: Membrane

827:CURT RS04910
gene id: 827:CURT_RS04910
uniprot id: A0A381E833
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

827:CURT RS04055
gene id: 827:CURT_RS04055
uniprot id: A0A381E9M3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

827:CURT RS05175
gene id: 827:CURT_RS05175
uniprot id: A0A381E7B9
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS02375
gene id: 827:CURT_RS02375
uniprot id: A0A381EC00
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

827:CURT RS00635
gene id: 827:CURT_RS00635
uniprot id: A0A2I1NA38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

827:CURT RS03960
gene id: 827:CURT_RS03960
uniprot id: A0A381E9W7
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

827:CURT RS00310
gene id: 827:CURT_RS00310
uniprot id: A0A2I1N9U0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

827:CURT RS00380
gene id: 827:CURT_RS00380
uniprot id: A0A381EDZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

827:CURT RS02530
gene id: 827:CURT_RS02530
uniprot id: A0A381EBA7
names: Similarity
messages: Belongs to the class-I fumarase family.

827:CURT RS04035
gene id: 827:CURT_RS04035
uniprot id: A0A381E9D1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

827:CURT RS05075
gene id: 827:CURT_RS05075
uniprot id: A0A381E7Y6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

827:CURT RS07380
gene id: 827:CURT_RS07380
uniprot id: A0A381E3V6
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS07800
gene id: 827:CURT_RS07800
uniprot id: A0A381E347
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

827:CURT RS00600
gene id: 827:CURT_RS00600
uniprot id: A0A2I1NA15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

827:CURT RS02240
gene id: 827:CURT_RS02240
uniprot id: A0A381EBU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

827:CURT RS05900
gene id: 827:CURT_RS05900
uniprot id: A0A381E6H2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

827:CURT RS06715
gene id: 827:CURT_RS06715
uniprot id: A0A381E4Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

827:CURT RS06800
gene id: 827:CURT_RS06800
uniprot id: A0A381E4W3
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

827:CURT RS00695
gene id: 827:CURT_RS00695
uniprot id: A0A381EDU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

827:CURT RS00320
gene id: 827:CURT_RS00320
uniprot id: A0A2I1N9V2
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

827:CURT RS03895
gene id: 827:CURT_RS03895
uniprot id: A0A381E9D3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

827:CURT RS00625
gene id: 827:CURT_RS00625
uniprot id: A0A2I1N9Z9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

827:CURT RS04580
gene id: 827:CURT_RS04580
uniprot id: A0A381E8A9
names: Similarity
messages: Belongs to the AAA ATPase family.

827:CURT RS04060
gene id: 827:CURT_RS04060
uniprot id: A0A381E986
names: Similarity
messages: Belongs to the YggT family.

827:CURT RS09165
gene id: 827:CURT_RS09165
uniprot id: A0A2I1N8N8
names: Similarity
messages: Belongs to the thioredoxin family.

827:CURT RS00355
gene id: 827:CURT_RS00355
uniprot id: A0A381EDR2
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

827:CURT RS07390
gene id: 827:CURT_RS07390
uniprot id: A0A381E3K8
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

827:CURT RS05200
gene id: 827:CURT_RS05200
uniprot id: A0A9Q4KMH1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

827:CURT RS04740
gene id: 827:CURT_RS04740
uniprot id: A0A381E8L7
names: Similarity
messages: Belongs to the HypD family.

827:CURT RS00660
gene id: 827:CURT_RS00660
uniprot id: A0A381EDI9
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS09235
gene id: 827:CURT_RS09235
uniprot id: A0A381EEL5
names: Similarity
messages: Belongs to the hcp beta-lactamase family.

827:CURT RS08155
gene id: 827:CURT_RS08155
uniprot id: A0A381E1X4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

827:CURT RS01060
gene id: 827:CURT_RS01060
uniprot id: A0A381ED29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

827:CURT RS03630
gene id: 827:CURT_RS03630
uniprot id: A0A381E9W0
names: Similarity
messages: Belongs to the UbiD family.

827:CURT RS03170
gene id: 827:CURT_RS03170
uniprot id: A0A381EAA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

827:CURT RS00295
gene id: 827:CURT_RS00295
uniprot id: A0A381EEJ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably functions as a manganese efflux pump.

827:CURT RS01895
gene id: 827:CURT_RS01895
uniprot id: A0A381EBU3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

827:CURT RS08050
gene id: 827:CURT_RS08050
uniprot id: A0A381E243
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

827:CURT RS07885
gene id: 827:CURT_RS07885
uniprot id: A0A381E2X3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

827:CURT RS02930
gene id: 827:CURT_RS02930
uniprot id: A0A381EAR8
names: Similarity
messages: Belongs to the fabD family.

827:CURT RS05130
gene id: 827:CURT_RS05130
uniprot id: A0A381E7M9
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

827:CURT RS02860
gene id: 827:CURT_RS02860
uniprot id: A0A381EAQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase B chain family.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Membrane

827:CURT RS05910
gene id: 827:CURT_RS05910
uniprot id: A0A381E5Z5
names: Similarity
messages: Belongs to the TrpC family.

827:CURT RS07325
gene id: 827:CURT_RS07325
uniprot id: A0A2I1NAL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

827:CURT RS04630
gene id: 827:CURT_RS04630
uniprot id: A0A381E8E1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

827:CURT RS08150
gene id: 827:CURT_RS08150
uniprot id: A0A381E2A0
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS01995
gene id: 827:CURT_RS01995
uniprot id: A0A381EC47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Cytoplasm

827:CURT RS09050
gene id: 827:CURT_RS09050
uniprot id: A0A381EF75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

827:CURT RS04730
gene id: 827:CURT_RS04730
uniprot id: A0A2I1NB55
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

827:CURT RS01110
gene id: 827:CURT_RS01110
uniprot id: A0A381ED05
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

827:CURT RS09240
gene id: 827:CURT_RS09240
uniprot id: S5UIE7
names: Similarity
messages: Belongs to the peptidase S8 family.

827:CURT RS07840
gene id: 827:CURT_RS07840
uniprot id: A0A381E2U3
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS09110
gene id: 827:CURT_RS09110
uniprot id: A0A381EEL3
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

827:CURT RS02360
gene id: 827:CURT_RS02360
uniprot id: A0A381EBQ1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

827:CURT RS00100
gene id: 827:CURT_RS00100
uniprot id: A0A381EEL1
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.

827:CURT RS04590
gene id: 827:CURT_RS04590
uniprot id: A0A381E8F5
names: Similarity
messages: Belongs to the MscS (TC 1.A.23) family.

827:CURT RS09075
gene id: 827:CURT_RS09075
uniprot id: A0A381EF61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

827:CURT RS01315
gene id: 827:CURT_RS01315
uniprot id: A0A381ECL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

827:CURT RS05420
gene id: 827:CURT_RS05420
uniprot id: A0A9Q4KQW6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

827:CURT RS01890
gene id: 827:CURT_RS01890
uniprot id: A0A381EBY0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

827:CURT RS07290
gene id: 827:CURT_RS07290
uniprot id: A0A381E3N3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

827:CURT RS07280
gene id: 827:CURT_RS07280
uniprot id: A0A381E3X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

827:CURT RS04425
gene id: 827:CURT_RS04425
uniprot id: A0A381E8U3
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS02540
gene id: 827:CURT_RS02540
uniprot id: A0A381EB66
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

827:CURT RS07170
gene id: 827:CURT_RS07170
uniprot id: A0A2I1NAF9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

827:CURT RS07830
gene id: 827:CURT_RS07830
uniprot id: A0A381E2N5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

827:CURT RS07370
gene id: 827:CURT_RS07370
uniprot id: A0A381E3V5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

827:CURT RS00565
gene id: 827:CURT_RS00565
uniprot id: A0A381EDR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

827:CURT RS07625
gene id: 827:CURT_RS07625
uniprot id: A0A381E3H8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

827:CURT RS09080
gene id: 827:CURT_RS09080
uniprot id: A0A381EEI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

827:CURT RS04490
gene id: 827:CURT_RS04490
uniprot id: A0A381E8T8
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS03710
gene id: 827:CURT_RS03710
uniprot id: A0A381E9W9
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

827:CURT RS01975
gene id: 827:CURT_RS01975
uniprot id: A0A381EBR9
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

827:CURT RS08680
gene id: 827:CURT_RS08680
uniprot id: A0A381EEY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

827:CURT RS05080
gene id: 827:CURT_RS05080
uniprot id: A0A381E7R9
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

827:CURT RS07160
gene id: 827:CURT_RS07160
uniprot id: A0A381E484
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

827:CURT RS06140
gene id: 827:CURT_RS06140
uniprot id: A0A381E5M5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

827:CURT RS07235
gene id: 827:CURT_RS07235
uniprot id: A0A2I1NAJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

827:CURT RS06930
gene id: 827:CURT_RS06930
uniprot id: A0A381E4H9
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

827:CURT RS00350
gene id: 827:CURT_RS00350
uniprot id: A0A2I1N9W5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

827:CURT RS04830
gene id: 827:CURT_RS04830
uniprot id: A0A381E7V1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

827:CURT RS04330
gene id: 827:CURT_RS04330
uniprot id: A0A381E936
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

827:CURT RS00630
gene id: 827:CURT_RS00630
uniprot id: A0A2I1N9Z8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

827:CURT RS06670
gene id: 827:CURT_RS06670
uniprot id: A0A381E4Y4
names: Function
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

827:CURT RS00585
gene id: 827:CURT_RS00585
uniprot id: A0A381EDX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

827:CURT RS02635
gene id: 827:CURT_RS02635
uniprot id: A0A381EB27
names: Similarity
messages: Belongs to the MlaA family.

827:CURT RS07260
gene id: 827:CURT_RS07260
uniprot id: A0A381E427
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

827:CURT RS00015
gene id: 827:CURT_RS00015
uniprot id: A0A381EE63
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

827:CURT RS07405
gene id: 827:CURT_RS07405
uniprot id: A0A381E3N9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell membrane
messages: Membrane

827:CURT RS03695
gene id: 827:CURT_RS03695
uniprot id: A0A381E9T5
names: Similarity
messages: Belongs to the CutA family.

827:CURT RS05895
gene id: 827:CURT_RS05895
uniprot id: A0A381E6G9
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

827:CURT RS05275
gene id: 827:CURT_RS05275
uniprot id: A0A381E715
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

827:CURT RS01460
gene id: 827:CURT_RS01460
uniprot id: A0A381ECI5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

827:CURT RS04440
gene id: 827:CURT_RS04440
uniprot id: A0A381E8V9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapD family.
messages: Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin-arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export.
messages: Cytoplasm
messages: Interacts with the cytoplasmic NapA precursor.

827:CURT RS07635
gene id: 827:CURT_RS07635
uniprot id: A0A381E338
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

827:CURT RS03105
gene id: 827:CURT_RS03105
uniprot id: A0A381EAJ0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

827:CURT RS06270
gene id: 827:CURT_RS06270
uniprot id: A0A381E5E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

827:CURT RS03060
gene id: 827:CURT_RS03060
uniprot id: A0A381EAW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

827:CURT RS01820
gene id: 827:CURT_RS01820
uniprot id: A0A381EC62
names: Function
names: Similarity
messages: Belongs to the phage GPA family.
messages: Possible endonuclease which induces a single-strand cut and initiates DNA replication.

827:CURT RS02820
gene id: 827:CURT_RS02820
uniprot id: A0A381EBE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

827:CURT RS01800
gene id: 827:CURT_RS01800
uniprot id: A0A2I1NC88
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS08200
gene id: 827:CURT_RS08200
uniprot id: A0A381E1Q5
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

827:CURT RS04280
gene id: 827:CURT_RS04280
uniprot id: A0A381E8Y0
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS07210
gene id: 827:CURT_RS07210
uniprot id: A0A2I1NAI1
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

827:CURT RS00465
gene id: 827:CURT_RS00465
uniprot id: A0A381EDV1
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS00135
gene id: 827:CURT_RS00135
uniprot id: A0A381EE73
names: Similarity
messages: Belongs to the RecJ family.

827:CURT RS06810
gene id: 827:CURT_RS06810
uniprot id: A0A381E4I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Dps family.
messages: Cytoplasm

827:CURT RS06180
gene id: 827:CURT_RS06180
uniprot id: A0A381E5G4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

827:CURT RS08230
gene id: 827:CURT_RS08230
uniprot id: A0A381E1S6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 2 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

827:CURT RS05000
gene id: 827:CURT_RS05000
uniprot id: A0A381E7K5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

827:CURT RS05170
gene id: 827:CURT_RS05170
uniprot id: A0A381E7Q6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

827:CURT RS07545
gene id: 827:CURT_RS07545
uniprot id: A0A381E3H1
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

827:CURT RS01090
gene id: 827:CURT_RS01090
uniprot id: A0A381ED47
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

827:CURT RS06290
gene id: 827:CURT_RS06290
uniprot id: A0A381E5E3
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

827:CURT RS04290
gene id: 827:CURT_RS04290
uniprot id: A0A381E901
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS00950
gene id: 827:CURT_RS00950
uniprot id: A0A381EDC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

827:CURT RS01035
gene id: 827:CURT_RS01035
uniprot id: A0A381ED41
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS08000
gene id: 827:CURT_RS08000
uniprot id: A0A381E2J8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Binds 1 Fe cation per subunit.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

827:CURT RS04915
gene id: 827:CURT_RS04915
uniprot id: A0A381E7V6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

827:CURT RS00570
gene id: 827:CURT_RS00570
uniprot id: A0A2I1NA06
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

827:CURT RS00010
gene id: 827:CURT_RS00010
uniprot id: A0A381EEC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta sliding clamp family.
messages: Cytoplasm

827:CURT RS04030
gene id: 827:CURT_RS04030
uniprot id: A0A381E974
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

827:CURT RS06560
gene id: 827:CURT_RS06560
uniprot id: A0A381E4Z3
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS04360
gene id: 827:CURT_RS04360
uniprot id: A0A381E8T9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

827:CURT RS03855
gene id: 827:CURT_RS03855
uniprot id: A0A381E9F4
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS04675
gene id: 827:CURT_RS04675
uniprot id: A0A381E891
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

827:CURT RS07350
gene id: 827:CURT_RS07350
uniprot id: A0A381E3W9
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

827:CURT RS07785
gene id: 827:CURT_RS07785
uniprot id: A0A381E354
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

827:CURT RS01500
gene id: 827:CURT_RS01500
uniprot id: A0A381ECF3
names: Subcellular Location Annotation
messages: Cytoplasm

827:CURT RS01095
gene id: 827:CURT_RS01095
uniprot id: A0A2I1NA94
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

827:CURT RS07330
gene id: 827:CURT_RS07330
uniprot id: A0A381E3J9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

827:CURT RS07610
gene id: 827:CURT_RS07610
uniprot id: A0A381E359
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS05245
gene id: 827:CURT_RS05245
uniprot id: A0A381E7M3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

827:CURT RS00770
gene id: 827:CURT_RS00770
uniprot id: A0A2I1NA44
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

827:CURT RS04645
gene id: 827:CURT_RS04645
uniprot id: A0A381E876
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerH subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

827:CURT RS05165
gene id: 827:CURT_RS05165
uniprot id: A0A381E7I6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

827:CURT RS04235
gene id: 827:CURT_RS04235
uniprot id: A0A381E8U9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS03040
gene id: 827:CURT_RS03040
uniprot id: A0A381EAX5
names: Function
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.

827:CURT RS02385
gene id: 827:CURT_RS02385
uniprot id: A0A381EBF1
names: Similarity
messages: Belongs to the hcp beta-lactamase family.

827:CURT RS06550
gene id: 827:CURT_RS06550
uniprot id: A0A381E5C1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

827:CURT RS01510
gene id: 827:CURT_RS01510
uniprot id: A0A381ECA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

827:CURT RS02760
gene id: 827:CURT_RS02760
uniprot id: A0A381EAY1
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

827:CURT RS07925
gene id: 827:CURT_RS07925
uniprot id: S5UK09
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholipase A1 family.
messages: Binds 1 Ca(2+) ion per monomer.
messages: Cell outer membrane
messages: Homodimer; dimerization is reversible, and the dimeric form is the active one.
messages: Membrane

827:CURT RS04890
gene id: 827:CURT_RS04890
uniprot id: A0A381E7R3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

827:CURT RS06215
gene id: 827:CURT_RS06215
uniprot id: A0A381E5Z2
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS05240
gene id: 827:CURT_RS05240
uniprot id: A0A2I1N9C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

827:CURT RS03005
gene id: 827:CURT_RS03005
uniprot id: A0A381EAZ1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS02220
gene id: 827:CURT_RS02220
uniprot id: A0A381EBG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

827:CURT RS02680
gene id: 827:CURT_RS02680
uniprot id: A0A2I1N8R6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 1 copper ion per subunit, denoted as copper B.
messages: Binds 2 heme groups per subunit, denoted as high- and low-spin.
messages: Membrane

827:CURT RS00285
gene id: 827:CURT_RS00285
uniprot id: A0A381EDU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

827:CURT RS06105
gene id: 827:CURT_RS06105
uniprot id: A0A381E5V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

827:CURT RS04900
gene id: 827:CURT_RS04900
uniprot id: A0A381E874
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

827:CURT RS03720
gene id: 827:CURT_RS03720
uniprot id: A0A381E9X2
names: Similarity
messages: Belongs to the NAD synthetase family.

827:CURT RS05270
gene id: 827:CURT_RS05270
uniprot id: A0A381E736
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane

827:CURT RS07285
gene id: 827:CURT_RS07285
uniprot id: A0A381E422
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

827:CURT RS00955
gene id: 827:CURT_RS00955
uniprot id: A0A381ED39
names: Caution
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS00220
gene id: 827:CURT_RS00220
uniprot id: A0A381EE04
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

827:CURT RS01415
gene id: 827:CURT_RS01415
uniprot id: A0A381ECF9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

827:CURT RS06640
gene id: 827:CURT_RS06640
uniprot id: A0A381E508
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

827:CURT RS05880
gene id: 827:CURT_RS05880
uniprot id: A0A381E613
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: The fumarate reductase enzyme complex is required for fumarate respiration. This subunit anchors the complex in the membrane and binds a diheme cytochrome b.

827:CURT RS07135
gene id: 827:CURT_RS07135
uniprot id: A0A381E445
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

827:CURT RS01345
gene id: 827:CURT_RS01345
uniprot id: A0A381ECI7
names: Similarity
messages: Belongs to the cytochrome c-552 family.

827:CURT RS04725
gene id: 827:CURT_RS04725
uniprot id: A0A381E860
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

827:CURT RS01490
gene id: 827:CURT_RS01490
uniprot id: A0A381ECR8
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

827:CURT RS07740
gene id: 827:CURT_RS07740
uniprot id: A0A381E380
names: Similarity
messages: Belongs to the protease inhibitor I11 (ecotin) family.

827:CURT RS04390
gene id: 827:CURT_RS04390
uniprot id: S5U2D5
names: Similarity
messages: Belongs to the bacterial secretin family.

827:CURT RS01055
gene id: 827:CURT_RS01055
uniprot id: A0A381EDN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

827:CURT RS02525
gene id: 827:CURT_RS02525
uniprot id: A0A381EB94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane

827:CURT RS02745
gene id: 827:CURT_RS02745
uniprot id: A0A381EAV4
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

827:CURT RS08975
gene id: 827:CURT_RS08975
uniprot id: A0A381EEX3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

827:CURT RS04000
gene id: 827:CURT_RS04000
uniprot id: A0A381E9J0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

827:CURT RS04105
gene id: 827:CURT_RS04105
uniprot id: A0A381E9I2
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

827:CURT RS04230
gene id: 827:CURT_RS04230
uniprot id: A0A381E905
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS02170
gene id: 827:CURT_RS02170
uniprot id: A0A381EBI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane
messages: Membrane

827:CURT RS03150
gene id: 827:CURT_RS03150
uniprot id: A0A2I1NBV4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

827:CURT RS05090
gene id: 827:CURT_RS05090
uniprot id: A0A381E7D5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

827:CURT RS00785
gene id: 827:CURT_RS00785
uniprot id: A0A381EDE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

827:CURT RS00025
gene id: 827:CURT_RS00025
uniprot id: A0A381EEE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

827:CURT RS02100
gene id: 827:CURT_RS02100
uniprot id: A0A381EBR5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes.
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Homodimer.

827:CURT RS04430
gene id: 827:CURT_RS04430
uniprot id: A0A381E932
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS06815
gene id: 827:CURT_RS06815
uniprot id: A0A381E4D1
names: Similarity
messages: Belongs to the GPI family.

827:CURT RS00825
gene id: 827:CURT_RS00825
uniprot id: A0A9Q4PT98
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

827:CURT RS09105
gene id: 827:CURT_RS09105
uniprot id: A0A381EEE8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS00390
gene id: 827:CURT_RS00390
uniprot id: A0A381EDW2
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

827:CURT RS04940
gene id: 827:CURT_RS04940
uniprot id: A0A381E879
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

827:CURT RS01015
gene id: 827:CURT_RS01015
uniprot id: A0A381EDF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

827:CURT RS02510
gene id: 827:CURT_RS02510
uniprot id: A0A381EBJ8
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

827:CURT RS07220
gene id: 827:CURT_RS07220
uniprot id: A0A2I1NB45
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

827:CURT RS00085
gene id: 827:CURT_RS00085
uniprot id: A0A381EEH0
names: Caution
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two nickel ions.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterohexamer of 3 UreA (alpha) and 3 UreB (beta) subunits.
messages: The orthologous protein is known as the alpha subunit (UreC) in most other bacteria.

827:CURT RS00835
gene id: 827:CURT_RS00835
uniprot id: A0A381EDC3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

827:CURT RS03280
gene id: 827:CURT_RS03280
uniprot id: A0A381EA51
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

827:CURT RS08245
gene id: 827:CURT_RS08245
uniprot id: A0A381E1R4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

827:CURT RS09085
gene id: 827:CURT_RS09085
uniprot id: A0A381EEX5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

827:CURT RS07675
gene id: 827:CURT_RS07675
uniprot id: A0A381E3G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

827:CURT RS06925
gene id: 827:CURT_RS06925
uniprot id: A0A381E4K8
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS05310
gene id: 827:CURT_RS05310
uniprot id: A0A381E6Z8
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

827:CURT RS05070
gene id: 827:CURT_RS05070
uniprot id: A0A381E7X2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

827:CURT RS07195
gene id: 827:CURT_RS07195
uniprot id: A0A381E3V8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

827:CURT RS02450
gene id: 827:CURT_RS02450
uniprot id: A0A381EB77
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

827:CURT RS06620
gene id: 827:CURT_RS06620
uniprot id: A0A381E542
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS03900
gene id: 827:CURT_RS03900
uniprot id: A0A381E9C8
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

827:CURT RS07865
gene id: 827:CURT_RS07865
uniprot id: A0A381E318
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS05235
gene id: 827:CURT_RS05235
uniprot id: A0A381E7E0
names: Similarity
messages: Belongs to the SAICAR synthetase family.

827:CURT RS05225
gene id: 827:CURT_RS05225
uniprot id: A0A381E748
names: Similarity
messages: Belongs to the ClpA/ClpB family.

827:CURT RS04595
gene id: 827:CURT_RS04595
uniprot id: A0A381E8K0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS06230
gene id: 827:CURT_RS06230
uniprot id: A0A381E5D9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnE family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.

827:CURT RS03080
gene id: 827:CURT_RS03080
uniprot id: A0A381EAP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

827:CURT RS01205
gene id: 827:CURT_RS01205
uniprot id: A0A381EDG2
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

827:CURT RS07180
gene id: 827:CURT_RS07180
uniprot id: A0A381E3U3
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS04995
gene id: 827:CURT_RS04995
uniprot id: A0A381E7J3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

827:CURT RS02065
gene id: 827:CURT_RS02065
uniprot id: S5UJZ0
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS03765
gene id: 827:CURT_RS03765
uniprot id: A0A381E9M1
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS00520
gene id: 827:CURT_RS00520
uniprot id: A0A2I1N9Z7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

827:CURT RS02825
gene id: 827:CURT_RS02825
uniprot id: A0A381EAV2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

827:CURT RS02830
gene id: 827:CURT_RS02830
uniprot id: A0A381EB55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

827:CURT RS03625
gene id: 827:CURT_RS03625
uniprot id: A0A381EAI9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

827:CURT RS05635
gene id: 827:CURT_RS05635
uniprot id: A0A381E6Q1
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

827:CURT RS00210
gene id: 827:CURT_RS00210
uniprot id: A0A381EEF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

827:CURT RS02175
gene id: 827:CURT_RS02175
uniprot id: A0A381EBY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

827:CURT RS08810
gene id: 827:CURT_RS08810
uniprot id: A0A381EET2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

827:CURT RS05805
gene id: 827:CURT_RS05805
uniprot id: A0A381E6M0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS09155
gene id: 827:CURT_RS09155
uniprot id: A0A381EEU0
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

827:CURT RS06745
gene id: 827:CURT_RS06745
uniprot id: A0A381E4L0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

827:CURT RS07615
gene id: 827:CURT_RS07615
uniprot id: A0A381E377
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS04710
gene id: 827:CURT_RS04710
uniprot id: A0A2I1NB95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

827:CURT RS07085
gene id: 827:CURT_RS07085
uniprot id: A0A381E4B8
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

827:CURT RS06160
gene id: 827:CURT_RS06160
uniprot id: A0A381E5S8
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

827:CURT RS09185
gene id: 827:CURT_RS09185
uniprot id: A0A381EEI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

827:CURT RS06190
gene id: 827:CURT_RS06190
uniprot id: A0A381E5U3
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS05105
gene id: 827:CURT_RS05105
uniprot id: S5U2A7
names: Similarity
messages: Belongs to the CapA family.

827:CURT RS09170
gene id: 827:CURT_RS09170
uniprot id: A0A381EF32
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

827:CURT RS05320
gene id: 827:CURT_RS05320
uniprot id: A0A2I1NBK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

827:CURT RS06225
gene id: 827:CURT_RS06225
uniprot id: A0A381E5H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

827:CURT RS01045
gene id: 827:CURT_RS01045
uniprot id: A0A381ECY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Cell inner membrane
messages: Membrane

827:CURT RS01465
gene id: 827:CURT_RS01465
uniprot id: A0A381ECM4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

827:CURT RS02305
gene id: 827:CURT_RS02305
uniprot id: A0A381EBF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

827:CURT RS06595
gene id: 827:CURT_RS06595
uniprot id: A0A381E4R1
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS00610
gene id: 827:CURT_RS00610
uniprot id: A0A381EDX3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

827:CURT RS01030
gene id: 827:CURT_RS01030
uniprot id: A0A381EDP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

827:CURT RS08885
gene id: 827:CURT_RS08885
uniprot id: A0A381EEQ6
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

827:CURT RS00090
gene id: 827:CURT_RS00090
uniprot id: A0A381EEU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UreE family.
messages: Cytoplasm
messages: Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.

827:CURT RS01335
gene id: 827:CURT_RS01335
uniprot id: A0A381ECZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

827:CURT RS00375
gene id: 827:CURT_RS00375
uniprot id: A0A381EE69
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

827:CURT RS02465
gene id: 827:CURT_RS02465
uniprot id: A0A381EB58
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.
messages: Cytoplasm
messages: Homodimer.

827:CURT RS07365
gene id: 827:CURT_RS07365
uniprot id: A0A381E3W6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

827:CURT RS04275
gene id: 827:CURT_RS04275
uniprot id: A0A381E9E5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

827:CURT RS09275
gene id: 827:CURT_RS09275
uniprot id: A0A381EEF4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

827:CURT RS08145
gene id: 827:CURT_RS08145
uniprot id: A0A381E1Y5
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

827:CURT RS07835
gene id: 827:CURT_RS07835
uniprot id: S5TT06
names: Similarity
messages: Belongs to the GSP E family.

827:CURT RS01405
gene id: 827:CURT_RS01405
uniprot id: A0A381ECW1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS03300
gene id: 827:CURT_RS03300
uniprot id: A0A381EA32
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

827:CURT RS03010
gene id: 827:CURT_RS03010
uniprot id: A0A381EAJ1
names: Caution
names: Function
names: Similarity
messages: Belongs to the IspF family.
messages: Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
messages: In the C-terminal section; belongs to the IspF family.
messages: In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS01305
gene id: 827:CURT_RS01305
uniprot id: A0A381ECR1
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

827:CURT RS07200
gene id: 827:CURT_RS07200
uniprot id: A0A381E3V4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

827:CURT RS02205
gene id: 827:CURT_RS02205
uniprot id: A0A381EBJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

827:CURT RS03305
gene id: 827:CURT_RS03305
uniprot id: A0A381EAR5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS05180
gene id: 827:CURT_RS05180
uniprot id: A0A381E7J6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane

827:CURT RS01765
gene id: 827:CURT_RS01765
uniprot id: A0A381EC57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

827:CURT RS00410
gene id: 827:CURT_RS00410
uniprot id: A0A381EDR9
names: Similarity
messages: Belongs to the hcp beta-lactamase family.

827:CURT RS02655
gene id: 827:CURT_RS02655
uniprot id: A0A381EBE0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

827:CURT RS01920
gene id: 827:CURT_RS01920
uniprot id: A0A381EBT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

827:CURT RS02775
gene id: 827:CURT_RS02775
uniprot id: A0A381EB08
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

827:CURT RS08665
gene id: 827:CURT_RS08665
uniprot id: A0A381EFN1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

827:CURT RS03195
gene id: 827:CURT_RS03195
uniprot id: A0A381EAM5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

827:CURT RS09190
gene id: 827:CURT_RS09190
uniprot id: A0A381EEC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

827:CURT RS00115
gene id: 827:CURT_RS00115
uniprot id: A0A381EE54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

827:CURT RS07945
gene id: 827:CURT_RS07945
uniprot id: A0A381E2D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

827:CURT RS09230
gene id: 827:CURT_RS09230
uniprot id: A0A381EEB6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS01525
gene id: 827:CURT_RS01525
uniprot id: A0A381ECE0
names: Similarity
messages: Belongs to the RutC family.

827:CURT RS06675
gene id: 827:CURT_RS06675
uniprot id: A0A381E535
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

827:CURT RS06095
gene id: 827:CURT_RS06095
uniprot id: A0A381E5W4
names: Subcellular Location Annotation
messages: Mitochondrion

827:CURT RS02355
gene id: 827:CURT_RS02355
uniprot id: A0A2I1NCR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

827:CURT RS07215
gene id: 827:CURT_RS07215
uniprot id: A0A2I1NAJ0
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

827:CURT RS03285
gene id: 827:CURT_RS03285
uniprot id: A0A381EAA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

827:CURT RS05330
gene id: 827:CURT_RS05330
uniprot id: A0A381E724
names: Similarity
messages: Belongs to the IMPACT family.

827:CURT RS02950
gene id: 827:CURT_RS02950
uniprot id: A0A381EAQ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

827:CURT RS07880
gene id: 827:CURT_RS07880
uniprot id: A0A381E2X8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

827:CURT RS04965
gene id: 827:CURT_RS04965
uniprot id: A0A2I1N985
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

827:CURT RS09055
gene id: 827:CURT_RS09055
uniprot id: A0A381EEJ4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

827:CURT RS05040
gene id: 827:CURT_RS05040
uniprot id: A0A381E7G6
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

827:CURT RS00275
gene id: 827:CURT_RS00275
uniprot id: A0A381EDZ3
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS04705
gene id: 827:CURT_RS04705
uniprot id: A0A381E8N8
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

827:CURT RS05055
gene id: 827:CURT_RS05055
uniprot id: A0A381E7Y3
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS07790
gene id: 827:CURT_RS07790
uniprot id: A0A381E351
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

827:CURT RS02000
gene id: 827:CURT_RS02000
uniprot id: A0A2I1NCA0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

827:CURT RS01470
gene id: 827:CURT_RS01470
uniprot id: A0A381ECD7
names: Similarity
messages: Belongs to the XseB family.

827:CURT RS08705
gene id: 827:CURT_RS08705
uniprot id: A0A381EF16
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

827:CURT RS00510
gene id: 827:CURT_RS00510
uniprot id: A0A381EDJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

827:CURT RS07010
gene id: 827:CURT_RS07010
uniprot id: A0A381E4L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

827:CURT RS03130
gene id: 827:CURT_RS03130
uniprot id: A0A381EAC6
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS04895
gene id: 827:CURT_RS04895
uniprot id: A0A381E816
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

827:CURT RS09130
gene id: 827:CURT_RS09130
uniprot id: A0A381EED8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

827:CURT RS08190
gene id: 827:CURT_RS08190
uniprot id: A0A381E267
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

827:CURT RS03700
gene id: 827:CURT_RS03700
uniprot id: A0A381E9W5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

827:CURT RS04865
gene id: 827:CURT_RS04865
uniprot id: A0A381E7U6
names: Similarity
messages: Belongs to the DprA/Smf family.

827:CURT RS06955
gene id: 827:CURT_RS06955
uniprot id: A0A381E491
names: Similarity
messages: Belongs to the LOG family.

827:CURT RS01740
gene id: 827:CURT_RS01740
uniprot id: A0A381ECF5
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

827:CURT RS08950
gene id: 827:CURT_RS08950
uniprot id: A0A381EET4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

827:CURT RS05140
gene id: 827:CURT_RS05140
uniprot id: A0A381E7T3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

827:CURT RS09030
gene id: 827:CURT_RS09030
uniprot id: A0A381EEM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

827:CURT RS07650
gene id: 827:CURT_RS07650
uniprot id: A0A381E3F1
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

827:CURT RS01670
gene id: 827:CURT_RS01670
uniprot id: A0A381EC94
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

827:CURT RS09020
gene id: 827:CURT_RS09020
uniprot id: A0A2I1N8N1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

827:CURT RS01285
gene id: 827:CURT_RS01285
uniprot id: A0A381ECS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

827:CURT RS00615
gene id: 827:CURT_RS00615
uniprot id: A0A2I1NA22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

827:CURT RS03605
gene id: 827:CURT_RS03605
uniprot id: A0A381EAK1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

827:CURT RS00890
gene id: 827:CURT_RS00890
uniprot id: A0A381EDL0
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

827:CURT RS00495
gene id: 827:CURT_RS00495
uniprot id: A0A381EDV6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

827:CURT RS02135
gene id: 827:CURT_RS02135
uniprot id: A0A381EBK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

827:CURT RS09025
gene id: 827:CURT_RS09025
uniprot id: A0A381EEJ7
names: Function
names: Similarity
messages: Belongs to the complex I 30 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

827:CURT RS02010
gene id: 827:CURT_RS02010
uniprot id: A0A381ECF7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

827:CURT RS01715
gene id: 827:CURT_RS01715
uniprot id: A0A9Q4PWX5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

827:CURT RS00750
gene id: 827:CURT_RS00750
uniprot id: A0A2I1NA18
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

827:CURT RS00555
gene id: 827:CURT_RS00555
uniprot id: A0A2I1NA14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

827:CURT RS02300
gene id: 827:CURT_RS02300
uniprot id: A0A2I1NCE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

827:CURT RS00400
gene id: 827:CURT_RS00400
uniprot id: A0A381EDY2
names: Similarity
messages: Belongs to the MreC family.

827:CURT RS01120
gene id: 827:CURT_RS01120
uniprot id: A0A381ED56
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

827:CURT RS03905
gene id: 827:CURT_RS03905
uniprot id: A0A381E9C2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

827:CURT RS07645
gene id: 827:CURT_RS07645
uniprot id: A0A381E3I8
names: Similarity
messages: Belongs to the polysaccharide synthase family.

827:CURT RS06075
gene id: 827:CURT_RS06075
uniprot id: A0A381E690
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

827:CURT RS00900
gene id: 827:CURT_RS00900
uniprot id: A0A381EDK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

827:CURT RS05885
gene id: 827:CURT_RS05885
uniprot id: A0A381E666
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

827:CURT RS09245
gene id: 827:CURT_RS09245
uniprot id: A0A381EEQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

827:CURT RS06060
gene id: 827:CURT_RS06060
uniprot id: A0A381E652
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

827:CURT RS04990
gene id: 827:CURT_RS04990
uniprot id: A0A381E839
names: Similarity
messages: Belongs to the PRORSD1 family.

827:CURT RS04110
gene id: 827:CURT_RS04110
uniprot id: A0A381E9M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

827:CURT RS00005
gene id: 827:CURT_RS00005
uniprot id: A0A381EE85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

827:CURT RS00105
gene id: 827:CURT_RS00105
uniprot id: A0A381EE49
names: Similarity
messages: Belongs to the UreD family.

827:CURT RS02890
gene id: 827:CURT_RS02890
uniprot id: A0A381EB33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

827:CURT RS01385
gene id: 827:CURT_RS01385
uniprot id: A0A2I1NC24
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

827:CURT RS07490
gene id: 827:CURT_RS07490
uniprot id: A0A381E392
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

827:CURT RS05285
gene id: 827:CURT_RS05285
uniprot id: A0A381E7D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

827:CURT RS07915
gene id: 827:CURT_RS07915
uniprot id: A0A381E2V1
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

827:CURT RS08920
gene id: 827:CURT_RS08920
uniprot id: A0A381EF50
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

827:CURT RS08685
gene id: 827:CURT_RS08685
uniprot id: A0A381EF76
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

827:CURT RS08895
gene id: 827:CURT_RS08895
uniprot id: A0A381EF57
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

827:CURT RS07015
gene id: 827:CURT_RS07015
uniprot id: A0A381E4G7
names: Similarity
messages: Belongs to the LacAB/RpiB family.

827:CURT RS04605
gene id: 827:CURT_RS04605
uniprot id: A0A381E8D9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS01915
gene id: 827:CURT_RS01915
uniprot id: A0A381EBX0
names: Similarity
messages: Belongs to the peptidase M16 family.

827:CURT RS07385
gene id: 827:CURT_RS07385
uniprot id: A0A2I1NAK0
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

827:CURT RS07125
gene id: 827:CURT_RS07125
uniprot id: A0A381E4A6
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

827:CURT RS04420
gene id: 827:CURT_RS04420
uniprot id: A0A381E8K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Membrane

827:CURT RS01780
gene id: 827:CURT_RS01780
uniprot id: A0A381EC03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

827:CURT RS00715
gene id: 827:CURT_RS00715
uniprot id: S5U2B3
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS05060
gene id: 827:CURT_RS05060
uniprot id: A0A381E7J4
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS08210
gene id: 827:CURT_RS08210
uniprot id: A0A381E1T6
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS07850
gene id: 827:CURT_RS07850
uniprot id: A0A381E2Y3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

827:CURT RS02865
gene id: 827:CURT_RS02865
uniprot id: A0A381EB42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase B chain family.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Membrane

827:CURT RS05855
gene id: 827:CURT_RS05855
uniprot id: A0A381E6F3
names: Similarity
messages: Belongs to the hcp beta-lactamase family.

827:CURT RS07115
gene id: 827:CURT_RS07115
uniprot id: A0A381E403
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

827:CURT RS02615
gene id: 827:CURT_RS02615
uniprot id: A0A381EBE3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

827:CURT RS02750
gene id: 827:CURT_RS02750
uniprot id: A0A2I1N8T6
names: Similarity
messages: Belongs to the UPF0751 family.

827:CURT RS00800
gene id: 827:CURT_RS00800
uniprot id: A0A381EDI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

827:CURT RS03265
gene id: 827:CURT_RS03265
uniprot id: A0A381EA49
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

827:CURT RS05035
gene id: 827:CURT_RS05035
uniprot id: A0A2I1N992
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

827:CURT RS05010
gene id: 827:CURT_RS05010
uniprot id: A0A381E7M0
names: Cofactor
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.

827:CURT RS07950
gene id: 827:CURT_RS07950
uniprot id: A0A381E298
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS06920
gene id: 827:CURT_RS06920
uniprot id: A0A381E4L6
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS00145
gene id: 827:CURT_RS00145
uniprot id: A0A381EE87
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

827:CURT RS04785
gene id: 827:CURT_RS04785
uniprot id: A0A381E8A7
names: Similarity
messages: Belongs to the ribF family.

827:CURT RS02870
gene id: 827:CURT_RS02870
uniprot id: A0A381EBC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

827:CURT RS00395
gene id: 827:CURT_RS00395
uniprot id: A0A2I1N9X7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

827:CURT RS05190
gene id: 827:CURT_RS05190
uniprot id: A0A381E7A5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

827:CURT RS04735
gene id: 827:CURT_RS04735
uniprot id: A0A2I1NB74
names: Similarity
messages: Belongs to the HupF/HypC family.

827:CURT RS02880
gene id: 827:CURT_RS02880
uniprot id: A0A381EB36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

827:CURT RS03180
gene id: 827:CURT_RS03180
uniprot id: A0A381EAF9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

827:CURT RS06845
gene id: 827:CURT_RS06845
uniprot id: A0A381E4N2
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

827:CURT RS00670
gene id: 827:CURT_RS00670
uniprot id: A0A381EDC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

827:CURT RS06795
gene id: 827:CURT_RS06795
uniprot id: A0A381E4Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

827:CURT RS02725
gene id: 827:CURT_RS02725
uniprot id: A0A2I1N8T8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

827:CURT RS06720
gene id: 827:CURT_RS06720
uniprot id: A0A381E522
names: Similarity
messages: Belongs to the PstS family.

827:CURT RS03270
gene id: 827:CURT_RS03270
uniprot id: A0A381EA44
names: Function
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
messages: Catalyzes the biosynthesis of agmatine from arginine.

827:CURT RS05745
gene id: 827:CURT_RS05745
uniprot id: A0A381E694
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

827:CURT RS08195
gene id: 827:CURT_RS08195
uniprot id: A0A381E1U4
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

827:CURT RS06175
gene id: 827:CURT_RS06175
uniprot id: A0A381E5K4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

827:CURT RS04345
gene id: 827:CURT_RS04345
uniprot id: A0A381E8P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

827:CURT RS06635
gene id: 827:CURT_RS06635
uniprot id: A0A381E536
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

827:CURT RS02970
gene id: 827:CURT_RS02970
uniprot id: A0A381EB82
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

827:CURT RS05255
gene id: 827:CURT_RS05255
uniprot id: A0A381E747
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

827:CURT RS09205
gene id: 827:CURT_RS09205
uniprot id: A0A381EEH2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS02875
gene id: 827:CURT_RS02875
uniprot id: A0A381EAT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

827:CURT RS04455
gene id: 827:CURT_RS04455
uniprot id: A0A381E8N4
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NapB family.
messages: Binds 2 heme C groups per subunit.
messages: Periplasm

827:CURT RS00780
gene id: 827:CURT_RS00780
uniprot id: A0A381EDB0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

827:CURT RS04355
gene id: 827:CURT_RS04355
uniprot id: A0A381E8P6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

827:CURT RS01330
gene id: 827:CURT_RS01330
uniprot id: A0A381ECJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

827:CURT RS06855
gene id: 827:CURT_RS06855
uniprot id: A0A381E4P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Cell inner membrane
messages: Membrane

827:CURT RS00525
gene id: 827:CURT_RS00525
uniprot id: A0A381EDM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

827:CURT RS03095
gene id: 827:CURT_RS03095
uniprot id: A0A381EAK4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

827:CURT RS06710
gene id: 827:CURT_RS06710
uniprot id: A0A381E4Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

827:CURT RS08255
gene id: 827:CURT_RS08255
uniprot id: A0A381E1Q6
names: Function
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

827:CURT RS01025
gene id: 827:CURT_RS01025
uniprot id: A0A381EDE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

827:CURT RS03315
gene id: 827:CURT_RS03315
uniprot id: A0A381EA89
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS02770
gene id: 827:CURT_RS02770
uniprot id: A0A381EAU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

827:CURT RS02370
gene id: 827:CURT_RS02370
uniprot id: A0A381EB97
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

827:CURT RS06870
gene id: 827:CURT_RS06870
uniprot id: A0A381E4G6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

827:CURT RS06840
gene id: 827:CURT_RS06840
uniprot id: A0A381E4Q5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS02730
gene id: 827:CURT_RS02730
uniprot id: A0A381EAV0
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

827:CURT RS01935
gene id: 827:CURT_RS01935
uniprot id: A0A381ECJ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS00325
gene id: 827:CURT_RS00325
uniprot id: A0A381EDR8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

827:CURT RS07175
gene id: 827:CURT_RS07175
uniprot id: A0A381E473
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M38 family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two zinc ions.
messages: Carboxylation allows a single lysine to coordinate two zinc ions.
messages: Catalyzes the hydrolytic cleavage of a subset of L-isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation.
messages: Cytoplasm

827:CURT RS00340
gene id: 827:CURT_RS00340
uniprot id: A0A381EEG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

827:CURT RS03955
gene id: 827:CURT_RS03955
uniprot id: A0A381E9H4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS02900
gene id: 827:CURT_RS02900
uniprot id: A0A381EAS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

827:CURT RS01965
gene id: 827:CURT_RS01965
uniprot id: A0A381EBU4
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

827:CURT RS07005
gene id: 827:CURT_RS07005
uniprot id: A0A381E4G8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

827:CURT RS03940
gene id: 827:CURT_RS03940
uniprot id: A0A381E9A4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

827:CURT RS08940
gene id: 827:CURT_RS08940
uniprot id: A0A381EEL0
names: Similarity
messages: Belongs to the hcp beta-lactamase family.

827:CURT RS02735
gene id: 827:CURT_RS02735
uniprot id: S5TT19
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

827:CURT RS08800
gene id: 827:CURT_RS08800
uniprot id: A0A381EEY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

827:CURT RS00265
gene id: 827:CURT_RS00265
uniprot id: A0A2I1N9V9
names: Cofactor
names: Function
messages: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

827:CURT RS08945
gene id: 827:CURT_RS08945
uniprot id: A0A381EET3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Secreted

827:CURT RS04215
gene id: 827:CURT_RS04215
uniprot id: A0A2I1NBF8
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS04770
gene id: 827:CURT_RS04770
uniprot id: A0A2I1NB82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

827:CURT RS02885
gene id: 827:CURT_RS02885
uniprot id: A0A381EAP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

827:CURT RS02350
gene id: 827:CURT_RS02350
uniprot id: A0A381EC10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

827:CURT RS00480
gene id: 827:CURT_RS00480
uniprot id: A0A381EDR6
names: Cofactor
names: Similarity
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.

827:CURT RS00960
gene id: 827:CURT_RS00960
uniprot id: A0A381ED68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

827:CURT RS07550
gene id: 827:CURT_RS07550
uniprot id: A0A381E3L9
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

827:CURT RS05755
gene id: 827:CURT_RS05755
uniprot id: A0A381E6Q3
names: Similarity
messages: Belongs to the glutamate synthase family.

827:CURT RS08170
gene id: 827:CURT_RS08170
uniprot id: A0A381E1W3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

827:CURT RS01255
gene id: 827:CURT_RS01255
uniprot id: A0A381ECQ9
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS08675
gene id: 827:CURT_RS08675
uniprot id: A0A381EFB1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

827:CURT RS08915
gene id: 827:CURT_RS08915
uniprot id: A0A381EEQ2
names: Cofactor
names: Function
names: Similarity
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.

827:CURT RS08225
gene id: 827:CURT_RS08225
uniprot id: S5TT16
names: Similarity
messages: Belongs to the GSP E family.

827:CURT RS07100
gene id: 827:CURT_RS07100
uniprot id: A0A381E416
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

827:CURT RS09070
gene id: 827:CURT_RS09070
uniprot id: A0A381EET7
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS02495
gene id: 827:CURT_RS02495
uniprot id: A0A381EB75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the formate dehydrogenase gamma subunit family.
messages: Membrane

827:CURT RS00910
gene id: 827:CURT_RS00910
uniprot id: A0A381ED93
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

827:CURT RS08700
gene id: 827:CURT_RS08700
uniprot id: A0A381EF08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuC/DcuD transporter (TC 2.A.61) family.
messages: Membrane

827:CURT RS08460
gene id: 827:CURT_RS08460
uniprot id: A0A381E188
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.

827:CURT RS06065
gene id: 827:CURT_RS06065
uniprot id: A0A381E5R8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

827:CURT RS08220
gene id: 827:CURT_RS08220
uniprot id: A0A381E1U6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

827:CURT RS01430
gene id: 827:CURT_RS01430
uniprot id: A0A381ECG2
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

827:CURT RS07275
gene id: 827:CURT_RS07275
uniprot id: A0A2I1NAK8
names: Similarity
messages: Belongs to the UPF0763 family.

827:CURT RS09015
gene id: 827:CURT_RS09015
uniprot id: A0A381EEP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

827:CURT RS07555
gene id: 827:CURT_RS07555
uniprot id: A0A2I1NAQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

827:CURT RS04780
gene id: 827:CURT_RS04780
uniprot id: A0A381E821
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
messages: Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS07020
gene id: 827:CURT_RS07020
uniprot id: A0A381E469
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

827:CURT RS04700
gene id: 827:CURT_RS04700
uniprot id: A0A381E8A0
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

827:CURT RS02435
gene id: 827:CURT_RS02435
uniprot id: A0A381EB78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Cell inner membrane
messages: Membrane

827:CURT RS04840
gene id: 827:CURT_RS04840
uniprot id: A0A381E7U9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

827:CURT RS01130
gene id: 827:CURT_RS01130
uniprot id: A0A381ED07
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

827:CURT RS03950
gene id: 827:CURT_RS03950
uniprot id: A0A381E9L6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

827:CURT RS09065
gene id: 827:CURT_RS09065
uniprot id: A0A381EEI8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

827:CURT RS07665
gene id: 827:CURT_RS07665
uniprot id: A0A381E3D8
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

827:CURT RS06460
gene id: 827:CURT_RS06460
uniprot id: A0A381E557
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS01565
gene id: 827:CURT_RS01565
uniprot id: A0A381EC97
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

827:CURT RS03730
gene id: 827:CURT_RS03730
uniprot id: A0A381E9P5
names: Similarity
messages: Belongs to the AdoMet synthase family.

827:CURT RS02020
gene id: 827:CURT_RS02020
uniprot id: A0A381EC36
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

827:CURT RS00595
gene id: 827:CURT_RS00595
uniprot id: A0A2I1NA01
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

827:CURT RS05020
gene id: 827:CURT_RS05020
uniprot id: A0A381E7P0
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

827:CURT RS02855
gene id: 827:CURT_RS02855
uniprot id: A0A381EB46
names: Similarity
messages: Belongs to the ParB family.

827:CURT RS03690
gene id: 827:CURT_RS03690
uniprot id: A0A381E9R2
names: Similarity
messages: Belongs to the threonine synthase family.

827:CURT RS06535
gene id: 827:CURT_RS06535
uniprot id: A0A381E5D1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

827:CURT RS01790
gene id: 827:CURT_RS01790
uniprot id: A0A381EBZ2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS01750
gene id: 827:CURT_RS01750
uniprot id: A0A381ECF6
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS00790
gene id: 827:CURT_RS00790
uniprot id: A0A381ED94
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

827:CURT RS07805
gene id: 827:CURT_RS07805
uniprot id: A0A381E378
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

827:CURT RS03320
gene id: 827:CURT_RS03320
uniprot id: A0A381EAA8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20 family.
messages: Binds 2 Zn(2+) ions per subunit.

827:CURT RS01005
gene id: 827:CURT_RS01005
uniprot id: A0A381EDQ4
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

827:CURT RS07720
gene id: 827:CURT_RS07720
uniprot id: A0A381E2W3
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS08405
gene id: 827:CURT_RS08405
uniprot id: A0A381E1G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

827:CURT RS00095
gene id: 827:CURT_RS00095
uniprot id: A0A381EE64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreF family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

827:CURT RS09225
gene id: 827:CURT_RS09225
uniprot id: A0A381EE97
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS01270
gene id: 827:CURT_RS01270
uniprot id: A0A381ED23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

827:CURT RS03245
gene id: 827:CURT_RS03245
uniprot id: A0A381EAJ5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

827:CURT RS08285
gene id: 827:CURT_RS08285
uniprot id: A0A381E1Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

827:CURT RS07440
gene id: 827:CURT_RS07440
uniprot id: A0A381E3X2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

827:CURT RS05015
gene id: 827:CURT_RS05015
uniprot id: A0A381E7W2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

827:CURT RS02265
gene id: 827:CURT_RS02265
uniprot id: A0A381EBK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.
messages: Catalyzes the sodium-dependent transport of glutamate.
messages: Cell membrane

827:CURT RS01940
gene id: 827:CURT_RS01940
uniprot id: A0A381EBT4
names: Similarity
messages: Belongs to the glutamine synthetase family.

827:CURT RS03125
gene id: 827:CURT_RS03125
uniprot id: A0A381EAR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

827:CURT RS01795
gene id: 827:CURT_RS01795
uniprot id: A0A381ECD9
names: Similarity
messages: Belongs to the thioredoxin family. DsbA subfamily.

827:CURT RS01745
gene id: 827:CURT_RS01745
uniprot id: A0A381EC12
names: Similarity
messages: Belongs to the GARS family.

827:CURT RS06505
gene id: 827:CURT_RS06505
uniprot id: A0A381E530
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

827:CURT RS03890
gene id: 827:CURT_RS03890
uniprot id: A0A381EA13
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS07595
gene id: 827:CURT_RS07595
uniprot id: A0A381E3N4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

827:CURT RS01050
gene id: 827:CURT_RS01050
uniprot id: A0A381EDD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

827:CURT RS01930
gene id: 827:CURT_RS01930
uniprot id: A0A381EC14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

827:CURT RS07265
gene id: 827:CURT_RS07265
uniprot id: A0A381E477
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

827:CURT RS01275
gene id: 827:CURT_RS01275
uniprot id: A0A381EDD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

827:CURT RS02155
gene id: 827:CURT_RS02155
uniprot id: A0A381EBI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

827:CURT RS04020
gene id: 827:CURT_RS04020
uniprot id: A0A381E9E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

827:CURT RS01885
gene id: 827:CURT_RS01885
uniprot id: A0A381EBU2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

827:CURT RS00515
gene id: 827:CURT_RS00515
uniprot id: A0A381EDT3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

827:CURT RS02955
gene id: 827:CURT_RS02955
uniprot id: A0A381EB06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

827:CURT RS00875
gene id: 827:CURT_RS00875
uniprot id: A0A381EDL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

827:CURT RS07855
gene id: 827:CURT_RS07855
uniprot id: A0A381E2L6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

827:CURT RS07355
gene id: 827:CURT_RS07355
uniprot id: A0A381E3W5
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

827:CURT RS02430
gene id: 827:CURT_RS02430
uniprot id: A0A381EBM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Cell membrane
messages: Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
messages: Membrane
messages: The accessory proteins ExbB and ExbD seem to form a complex with TonB.

827:CURT RS09215
gene id: 827:CURT_RS09215
uniprot id: A0A381EEB1
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS02695
gene id: 827:CURT_RS02695
uniprot id: A0A381EAZ0
names: Cofactor
names: Similarity
messages: Belongs to the CcoP / FixP family.
messages: Binds 2 heme C groups per subunit.

827:CURT RS02440
gene id: 827:CURT_RS02440
uniprot id: A0A381EBM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

827:CURT RS00050
gene id: 827:CURT_RS00050
uniprot id: A0A381EE53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

827:CURT RS08380
gene id: 827:CURT_RS08380
uniprot id: A0A381E1H0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

827:CURT RS09120
gene id: 827:CURT_RS09120
uniprot id: A0A381EEF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

827:CURT RS07205
gene id: 827:CURT_RS07205
uniprot id: A0A381E3Q4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

827:CURT RS04825
gene id: 827:CURT_RS04825
uniprot id: A0A2I1NB72
names: Similarity
messages: Belongs to the Nudix hydrolase family.

827:CURT RS01540
gene id: 827:CURT_RS01540
uniprot id: A0A381ECQ2
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS00365
gene id: 827:CURT_RS00365
uniprot id: A0A381EEF9
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

827:CURT RS01150
gene id: 827:CURT_RS01150
uniprot id: A0A381EDJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

827:CURT RS02425
gene id: 827:CURT_RS02425
uniprot id: A0A381EBA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

827:CURT RS00180
gene id: 827:CURT_RS00180
uniprot id: A0A381EE15
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

827:CURT RS08275
gene id: 827:CURT_RS08275
uniprot id: A0A2I1NB40
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

827:CURT RS01280
gene id: 827:CURT_RS01280
uniprot id: A0A381ECP9
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

827:CURT RS07780
gene id: 827:CURT_RS07780
uniprot id: A0A381E2Y7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

827:CURT RS03615
gene id: 827:CURT_RS03615
uniprot id: A0A381EA84
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

827:CURT RS07630
gene id: 827:CURT_RS07630
uniprot id: A0A381E3J6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

827:CURT RS00185
gene id: 827:CURT_RS00185
uniprot id: A0A381EE29
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

827:CURT RS04800
gene id: 827:CURT_RS04800
uniprot id: A0A381E872
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS08250
gene id: 827:CURT_RS08250
uniprot id: A0A381E1S3
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

827:CURT RS01610
gene id: 827:CURT_RS01610
uniprot id: A0A381ECG1
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

827:CURT RS03945
gene id: 827:CURT_RS03945
uniprot id: A0A381E9D6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

827:CURT RS00330
gene id: 827:CURT_RS00330
uniprot id: A0A381EE09
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS07445
gene id: 827:CURT_RS07445
uniprot id: A0A381E3F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

827:CURT RS00760
gene id: 827:CURT_RS00760
uniprot id: A0A2I1NA30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

827:CURT RS05290
gene id: 827:CURT_RS05290
uniprot id: A0A381E776
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

827:CURT RS05810
gene id: 827:CURT_RS05810
uniprot id: A0A381E6A3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

827:CURT RS09200
gene id: 827:CURT_RS09200
uniprot id: A0A381EEA2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

827:CURT RS02835
gene id: 827:CURT_RS02835
uniprot id: A0A381EAR4
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

827:CURT RS00540
gene id: 827:CURT_RS00540
uniprot id: A0A2I1N9Y9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

827:CURT RS01825
gene id: 827:CURT_RS01825
uniprot id: A0A381EBX2
names: Similarity
messages: Belongs to the bacterial secretin family.

827:CURT RS02200
gene id: 827:CURT_RS02200
uniprot id: A0A381EBX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

827:CURT RS07775
gene id: 827:CURT_RS07775
uniprot id: A0A381E366
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.

827:CURT RS07415
gene id: 827:CURT_RS07415
uniprot id: A0A381E3E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

827:CURT RS09100
gene id: 827:CURT_RS09100
uniprot id: A0A381EEK3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

827:CURT RS07585
gene id: 827:CURT_RS07585
uniprot id: A0A381E383
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

827:CURT RS09210
gene id: 827:CURT_RS09210
uniprot id: A0A381EEH6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS06210
gene id: 827:CURT_RS06210
uniprot id: A0A381E5I8
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS02105
gene id: 827:CURT_RS02105
uniprot id: A0A381EBT6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS06645
gene id: 827:CURT_RS06645
uniprot id: A0A2I1N901
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

827:CURT RS00195
gene id: 827:CURT_RS00195
uniprot id: A0A381EEC1
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

827:CURT RS04835
gene id: 827:CURT_RS04835
uniprot id: A0A381E7W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TatB family.
messages: Cell membrane

827:CURT RS00720
gene id: 827:CURT_RS00720
uniprot id: A0A381EDS6
names: Similarity
messages: Belongs to the hcp beta-lactamase family.

827:CURT RS06530
gene id: 827:CURT_RS06530
uniprot id: A0A381E577
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

827:CURT RS04515
gene id: 827:CURT_RS04515
uniprot id: A0A381E8E0
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

827:CURT RS08465
gene id: 827:CURT_RS08465
uniprot id: A0A381E1H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuC/DcuD transporter (TC 2.A.61) family.
messages: Membrane

827:CURT RS06890
gene id: 827:CURT_RS06890
uniprot id: A0A381E4M4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

827:CURT RS05740
gene id: 827:CURT_RS05740
uniprot id: A0A381E6R6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS00675
gene id: 827:CURT_RS00675
uniprot id: A0A381EDT5
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

827:CURT RS06050
gene id: 827:CURT_RS06050
uniprot id: A0A9Q4KLG7
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

827:CURT RS05875
gene id: 827:CURT_RS05875
uniprot id: A0A381E615
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

827:CURT RS07030
gene id: 827:CURT_RS07030
uniprot id: A0A381E464
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

827:CURT RS04310
gene id: 827:CURT_RS04310
uniprot id: A0A381E8R8
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

827:CURT RS00335
gene id: 827:CURT_RS00335
uniprot id: A0A381EE68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

827:CURT RS04080
gene id: 827:CURT_RS04080
uniprot id: A0A381E9D8
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS07430
gene id: 827:CURT_RS07430
uniprot id: S5TUT1
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS00130
gene id: 827:CURT_RS00130
uniprot id: A0A381EE34
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS06860
gene id: 827:CURT_RS06860
uniprot id: A0A381E4M2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

827:CURT RS05160
gene id: 827:CURT_RS05160
uniprot id: A0A381E7B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MlaE permease family.
messages: Membrane

827:CURT RS05280
gene id: 827:CURT_RS05280
uniprot id: A0A381E741
names: Cofactor
names: Similarity
messages: Belongs to the class-II DAHP synthase family.
messages: Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.

827:CURT RS08695
gene id: 827:CURT_RS08695
uniprot id: A0A2I1NB54
names: Similarity
messages: Belongs to the peptidase S51 family.

827:CURT RS04205
gene id: 827:CURT_RS04205
uniprot id: A0A381E9H2
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

827:CURT RS07035
gene id: 827:CURT_RS07035
uniprot id: A0A381E4K6
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

827:CURT RS00680
gene id: 827:CURT_RS00680
uniprot id: A0A381EE30
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Homodimer.

827:CURT RS06465
gene id: 827:CURT_RS06465
uniprot id: A0A381E5E4
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS07345
gene id: 827:CURT_RS07345
uniprot id: A0A381E426
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

827:CURT RS01520
gene id: 827:CURT_RS01520
uniprot id: A0A381ED20
names: Similarity
names: Subunit
messages: Belongs to the peptidase M20A family. DapE subfamily.
messages: Homodimer.

827:CURT RS02630
gene id: 827:CURT_RS02630
uniprot id: A0A381EB02
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

827:CURT RS00530
gene id: 827:CURT_RS00530
uniprot id: A0A2I1N9X8
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

827:CURT RS03220
gene id: 827:CURT_RS03220
uniprot id: A0A381EA67
names: Similarity
messages: Belongs to the hcp beta-lactamase family.

827:CURT RS01425
gene id: 827:CURT_RS01425
uniprot id: A0A381ECP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

827:CURT RS07110
gene id: 827:CURT_RS07110
uniprot id: A0A381E3Y3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

827:CURT RS08185
gene id: 827:CURT_RS08185
uniprot id: A0A381E1V3
names: Cofactor
names: Function
messages: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes.
messages: Binds 1 zinc ion per subunit.

827:CURT RS04570
gene id: 827:CURT_RS04570
uniprot id: A0A381E8V3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-transferase family. Bpt subfamily.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.

827:CURT RS06765
gene id: 827:CURT_RS06765
uniprot id: A0A381E4K1
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS00775
gene id: 827:CURT_RS00775
uniprot id: A0A381EDJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

827:CURT RS04820
gene id: 827:CURT_RS04820
uniprot id: A0A381E818
names: Similarity
messages: Belongs to the aspartokinase family.

827:CURT RS04545
gene id: 827:CURT_RS04545
uniprot id: A0A381E8C4
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

827:CURT RS01600
gene id: 827:CURT_RS01600
uniprot id: A0A381EC82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

827:CURT RS01450
gene id: 827:CURT_RS01450
uniprot id: A0A381ECT8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

827:CURT RS06975
gene id: 827:CURT_RS06975
uniprot id: A0A381E4J4
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS05860
gene id: 827:CURT_RS05860
uniprot id: A0A381E675
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

827:CURT RS03665
gene id: 827:CURT_RS03665
uniprot id: A0A381EA52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

827:CURT RS00545
gene id: 827:CURT_RS00545
uniprot id: A0A2I1N9Z0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

827:CURT RS04755
gene id: 827:CURT_RS04755
uniprot id: A0A381E804
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

827:CURT RS06990
gene id: 827:CURT_RS06990
uniprot id: A0A381E488
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

827:CURT RS00345
gene id: 827:CURT_RS00345
uniprot id: A0A381EDW4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

827:CURT RS08175
gene id: 827:CURT_RS08175
uniprot id: A0A381E1X8
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

827:CURT RS03980
gene id: 827:CURT_RS03980
uniprot id: A0A381E9D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

827:CURT RS01250
gene id: 827:CURT_RS01250
uniprot id: A0A381EDE2
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS04025
gene id: 827:CURT_RS04025
uniprot id: A0A381E953
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

827:CURT RS06155
gene id: 827:CURT_RS06155
uniprot id: A0A381E5K1
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

827:CURT RS08020
gene id: 827:CURT_RS08020
uniprot id: A0A2I1NAY3
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

827:CURT RS01950
gene id: 827:CURT_RS01950
uniprot id: A0A381EBX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

827:CURT RS06785
gene id: 827:CURT_RS06785
uniprot id: A0A381E4F1
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

827:CURT RS04795
gene id: 827:CURT_RS04795
uniprot id: A0A2I1NB84
names: Similarity
messages: Belongs to the TlyA family.

827:CURT RS08880
gene id: 827:CURT_RS08880
uniprot id: A0A381EEW5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: Binds 1 Fe cation per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins.

827:CURT RS01365
gene id: 827:CURT_RS01365
uniprot id: A0A381ECL9
names: Subcellular Location Annotation
messages: Membrane

827:CURT RS01925
gene id: 827:CURT_RS01925
uniprot id: A0A381EBY8
names: Similarity
messages: Belongs to the ThrE exporter (TC 2.A.79) family.

827:CURT RS01000
gene id: 827:CURT_RS01000
uniprot id: A0A381EDF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

827:CURT RS02780
gene id: 827:CURT_RS02780
uniprot id: A0A381EBG7
names: Similarity
messages: Belongs to the TrpF family.

827:CURT RS03275
gene id: 827:CURT_RS03275
uniprot id: A0A381EA99
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

827:CURT RS07165
gene id: 827:CURT_RS07165
uniprot id: A0A2I1NAH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

827:CURT RS08295
gene id: 827:CURT_RS08295
uniprot id: A0A381E1N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

827:CURT RS00245
gene id: 827:CURT_RS00245
uniprot id: A0A381EEM3
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

827:CURT RS04415
gene id: 827:CURT_RS04415
uniprot id: A0A381E8K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

827:CURT RS04220
gene id: 827:CURT_RS04220
uniprot id: S5U289
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Membrane

827:CURT RS02165
gene id: 827:CURT_RS02165
uniprot id: A0A381EBX3
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

827:CURT RS00405
gene id: 827:CURT_RS00405
uniprot id: A0A381EDY7
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

827:CURT RS08750
gene id: 827:CURT_RS08750
uniprot id: A0A381EEV3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

827:CURT RS05210
gene id: 827:CURT_RS05210
uniprot id: A0A381E793
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

827:CURT RS03715
gene id: 827:CURT_RS03715
uniprot id: A0A381EA19
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

827:CURT RS04860
gene id: 827:CURT_RS04860
uniprot id: A0A381E7S8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

827:CURT RS04090
gene id: 827:CURT_RS04090
uniprot id: A0A381E9N3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

827:CURT RS04410
gene id: 827:CURT_RS04410
uniprot id: S5UJW2
names: Similarity
messages: Belongs to the GSP E family.

827:CURT RS07435
gene id: 827:CURT_RS07435
uniprot id: A0A381E3R8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

827:CURT RS00665
gene id: 827:CURT_RS00665
uniprot id: A0A381EDV0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

827:CURT RS03740
gene id: 827:CURT_RS03740
uniprot id: A0A381EAB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

827:CURT RS03860
gene id: 827:CURT_RS03860
uniprot id: A0A381E9I7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

827:CURT RS02210
gene id: 827:CURT_RS02210
uniprot id: A0A381EBH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

827:CURT RS00305
gene id: 827:CURT_RS00305
uniprot id: A0A381EEA4
names: Similarity
messages: Belongs to the universal stress protein A family.

827:CURT RS09005
gene id: 827:CURT_RS09005
uniprot id: A0A381EFA0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

827:CURT RS05425
gene id: 827:CURT_RS05425
uniprot id: A0A381E723
names: Similarity
messages: Belongs to the hcp beta-lactamase family.