79929:MTBMA RS02770
gene id: 79929:MTBMA_RS02770
uniprot id: D9PVA8
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

79929:MTBMA RS08215
gene id: 79929:MTBMA_RS08215
uniprot id: D9PYF5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

79929:MTBMA RS00415
gene id: 79929:MTBMA_RS00415
uniprot id: D9PTZ6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

79929:MTBMA RS06475
gene id: 79929:MTBMA_RS06475
uniprot id: D9PXG6
names: Similarity
messages: Belongs to the HsdR family.

79929:MTBMA RS08710
gene id: 79929:MTBMA_RS08710
uniprot id: D9PYQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
messages: Homotetramer; dimer of dimers.

79929:MTBMA RS01550
gene id: 79929:MTBMA_RS01550
uniprot id: P80900
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

79929:MTBMA RS02560
gene id: 79929:MTBMA_RS02560
uniprot id: D9PV67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

79929:MTBMA RS03470
gene id: 79929:MTBMA_RS03470
uniprot id: D9PVQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

79929:MTBMA RS06290
gene id: 79929:MTBMA_RS06290
uniprot id: D9PXD0
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

79929:MTBMA RS08765
gene id: 79929:MTBMA_RS08765
uniprot id: D9PYR4
names: Similarity
messages: Belongs to the UPF0147 family.

79929:MTBMA RS06380
gene id: 79929:MTBMA_RS06380
uniprot id: D9PXE8
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS07230
gene id: 79929:MTBMA_RS07230
uniprot id: D9PXW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

79929:MTBMA RS00440
gene id: 79929:MTBMA_RS00440
uniprot id: D9PU02
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

79929:MTBMA RS00770
gene id: 79929:MTBMA_RS00770
uniprot id: D9PU68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

79929:MTBMA RS05770
gene id: 79929:MTBMA_RS05770
uniprot id: D9PX27
names: Caution
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS07325
gene id: 79929:MTBMA_RS07325
uniprot id: D9PXY3
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

79929:MTBMA RS03210
gene id: 79929:MTBMA_RS03210
uniprot id: D9PVJ9
names: Similarity
messages: Belongs to the DEAD box helicase family.

79929:MTBMA RS03395
gene id: 79929:MTBMA_RS03395
uniprot id: D9PVN7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

79929:MTBMA RS02660
gene id: 79929:MTBMA_RS02660
uniprot id: D9PV85
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

79929:MTBMA RS07555
gene id: 79929:MTBMA_RS07555
uniprot id: P11562
names: Activity Regulation
names: Cofactor
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid (PubMed:3350018, PubMed:9367957). Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state (PubMed:9030728).
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis (PubMed:2269306, PubMed:3350018). Neither N-6-mercaptohexanoylthreonine phosphate (H-S-HxoTP) nor N-8-mercaptooctanoylthreonine phosphate (H-SOcoTP) nor any other thiol compound such as CoA or CoM can substitute for CoB as the electron donor (PubMed:3350018).
messages: Cytoplasm
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.
messages: Methyl-coenzyme M reductase activity is inhibited by 3-nitrooxypropanol (3-NOP) in vitro and in vivo, by oxidation of its active site Ni(I), which stops both growth and methanogenesis (PubMed:27140643). Is also inhibited by the reaction product CoM-S-S-CoB (PubMed:3350018).
messages: The MCR reaction has been shown to follow an ordered bi-bi ternary complex mechanism, in which methyl-SCoM must enter the MCR active site prior to CoB for a productive catalysis.
messages: There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contain mostly MCR I.

79929:MTBMA RS01030
gene id: 79929:MTBMA_RS01030
uniprot id: D9PUC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

79929:MTBMA RS03475
gene id: 79929:MTBMA_RS03475
uniprot id: D9PVQ3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

79929:MTBMA RS00005
gene id: 79929:MTBMA_RS00005
uniprot id: D9PYR8
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

79929:MTBMA RS08180
gene id: 79929:MTBMA_RS08180
uniprot id: D9PYE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

79929:MTBMA RS01010
gene id: 79929:MTBMA_RS01010
uniprot id: D9PUB6
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

79929:MTBMA RS05125
gene id: 79929:MTBMA_RS05125
uniprot id: D9PWP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

79929:MTBMA RS00425
gene id: 79929:MTBMA_RS00425
uniprot id: D9PTZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

79929:MTBMA RS01260
gene id: 79929:MTBMA_RS01260
uniprot id: D9PUG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

79929:MTBMA RS05835
gene id: 79929:MTBMA_RS05835
uniprot id: D9PX38
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

79929:MTBMA RS01930
gene id: 79929:MTBMA_RS01930
uniprot id: D9PUU4
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

79929:MTBMA RS06330
gene id: 79929:MTBMA_RS06330
uniprot id: P58818
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DNA photolyase class-2 family.
messages: Binds 1 F420 non-covalently per subunit. The F420 is in its oxidized state.
messages: Binds 1 FAD. The FAD is in its reduced state.
messages: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation.

79929:MTBMA RS08040
gene id: 79929:MTBMA_RS08040
uniprot id: D9PYC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

79929:MTBMA RS00270
gene id: 79929:MTBMA_RS00270
uniprot id: D9PYW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ModE family.
messages: Membrane

79929:MTBMA RS08425
gene id: 79929:MTBMA_RS08425
uniprot id: D9PYJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

79929:MTBMA RS05240
gene id: 79929:MTBMA_RS05240
uniprot id: D9PWR9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

79929:MTBMA RS01690
gene id: 79929:MTBMA_RS01690
uniprot id: D9PUP6
names: Similarity
messages: Belongs to the thymidylate kinase family.

79929:MTBMA RS01730
gene id: 79929:MTBMA_RS01730
uniprot id: D9PUQ4
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

79929:MTBMA RS05690
gene id: 79929:MTBMA_RS05690
uniprot id: D9PX12
names: Similarity
messages: Belongs to the UPF0047 family.

79929:MTBMA RS06045
gene id: 79929:MTBMA_RS06045
uniprot id: D9PX80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

79929:MTBMA RS02630
gene id: 79929:MTBMA_RS02630
uniprot id: D9PV79
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

79929:MTBMA RS03000
gene id: 79929:MTBMA_RS03000
uniprot id: Q57109
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

79929:MTBMA RS00745
gene id: 79929:MTBMA_RS00745
uniprot id: D9PU63
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

79929:MTBMA RS06550
gene id: 79929:MTBMA_RS06550
uniprot id: D9PXI1
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

79929:MTBMA RS06375
gene id: 79929:MTBMA_RS06375
uniprot id: D9PXE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

79929:MTBMA RS00430
gene id: 79929:MTBMA_RS00430
uniprot id: D9PU00
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent oxidoreductase 2 family.
messages: Binds 1 flavin covalently per subunit.
messages: Catalyzes the reduction of fumarate with reduced coenzyme M (CoM-S-H) and coenzyme B (CoB-S-H). In vitro, is able to reduces fumarate with reduced benzyl viologen, oxidize CoM-S-H and CoB-S-H to CoM-S-S-CoB with methylene blue, and reduce CoM-S-S-CoB with reduced benzyl viologen. The enzyme has specificity for the two thiol compounds as the CoB--CoM heterodisulfide reductase. The enzyme is very sensitive to oxygen.
messages: Cytoplasm
messages: Subunit A of the heterodimeric fumarate reductase of methanogenic Archaea, composed of subunits A (TfrA) and B (TfrB).

79929:MTBMA RS03320
gene id: 79929:MTBMA_RS03320
uniprot id: D9PVM2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS03480
gene id: 79929:MTBMA_RS03480
uniprot id: D9PVQ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

79929:MTBMA RS03135
gene id: 79929:MTBMA_RS03135
uniprot id: D9PVI4
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

79929:MTBMA RS07175
gene id: 79929:MTBMA_RS07175
uniprot id: D9PXV2
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

79929:MTBMA RS04875
gene id: 79929:MTBMA_RS04875
uniprot id: D9PWJ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

79929:MTBMA RS03825
gene id: 79929:MTBMA_RS03825
uniprot id: D9PVX6
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS08345
gene id: 79929:MTBMA_RS08345
uniprot id: D9PYH9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

79929:MTBMA RS02485
gene id: 79929:MTBMA_RS02485
uniprot id: D9PV52
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

79929:MTBMA RS06650
gene id: 79929:MTBMA_RS06650
uniprot id: D9PXK1
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

79929:MTBMA RS00800
gene id: 79929:MTBMA_RS00800
uniprot id: D9PU73
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

79929:MTBMA RS05615
gene id: 79929:MTBMA_RS05615
uniprot id: D9PWZ6
names: Cofactor
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Binds 1 Fe(2+) ion per subunit. The iron ion 2 is coordinated via four histidines and one cysteine residue.
messages: Binds 1 Fe(3+) ion per subunit. The iron ion 1 is coordinated via 4 cysteine residues.

79929:MTBMA RS07340
gene id: 79929:MTBMA_RS07340
uniprot id: D9PXY6
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily.
messages: Binds 1 Zn(2+) ion per subunit. This ion is coordinated with 2 cysteines, 1 glutamate and a water molecule that dissociates from the zinc ion to allow the coordination of the amino group of the serine substrate, which is essential for catalysis.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is presumably involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS05795
gene id: 79929:MTBMA_RS05795
uniprot id: D9PX30
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

79929:MTBMA RS00080
gene id: 79929:MTBMA_RS00080
uniprot id: D9PYT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
messages: Cell membrane
messages: Membrane

79929:MTBMA RS00055
gene id: 79929:MTBMA_RS00055
uniprot id: D9PYS8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

79929:MTBMA RS07355
gene id: 79929:MTBMA_RS07355
uniprot id: D9PXY9
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

79929:MTBMA RS04615
gene id: 79929:MTBMA_RS04615
uniprot id: D9PWD9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

79929:MTBMA RS01725
gene id: 79929:MTBMA_RS01725
uniprot id: D9PUQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

79929:MTBMA RS04975
gene id: 79929:MTBMA_RS04975
uniprot id: D9PWL3
names: Similarity
messages: Belongs to the UDPGP type 2 family.

79929:MTBMA RS04620
gene id: 79929:MTBMA_RS04620
uniprot id: D9PWE0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS04080
gene id: 79929:MTBMA_RS04080
uniprot id: D9PW27
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

79929:MTBMA RS01240
gene id: 79929:MTBMA_RS01240
uniprot id: D9PUG3
names: Similarity
messages: Belongs to the phosphosulfolactate synthase family.

79929:MTBMA RS06850
gene id: 79929:MTBMA_RS06850
uniprot id: D9PXP1
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

79929:MTBMA RS06360
gene id: 79929:MTBMA_RS06360
uniprot id: P56811
names: Function
names: Similarity
messages: Belongs to the Tfx family.
messages: Transcriptional activator of the fmdECB operon.

79929:MTBMA RS01205
gene id: 79929:MTBMA_RS01205
uniprot id: D9PUF5
names: Similarity
messages: Belongs to the glutamate synthase family.

79929:MTBMA RS03940
gene id: 79929:MTBMA_RS03940
uniprot id: Q9P9J4
names: Similarity
messages: Belongs to the FTR family.

79929:MTBMA RS01510
gene id: 79929:MTBMA_RS01510
uniprot id: D9PUL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

79929:MTBMA RS01555
gene id: 79929:MTBMA_RS01555
uniprot id: P80903
names: Cofactor
names: Subunit
messages: Binds 2 [4Fe-4S] clusters.
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

79929:MTBMA RS01980
gene id: 79929:MTBMA_RS01980
uniprot id: D9PUV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

79929:MTBMA RS05105
gene id: 79929:MTBMA_RS05105
uniprot id: D9PWN9
names: Function
names: Similarity
messages: Belongs to the P(II) protein family.
messages: Could be involved in the regulation of nitrogen fixation.

79929:MTBMA RS03280
gene id: 79929:MTBMA_RS03280
uniprot id: D9PVL4
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

79929:MTBMA RS02905
gene id: 79929:MTBMA_RS02905
uniprot id: D9PVD8
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

79929:MTBMA RS01615
gene id: 79929:MTBMA_RS01615
uniprot id: Q50744
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm
messages: Homotetramer.

79929:MTBMA RS01990
gene id: 79929:MTBMA_RS01990
uniprot id: D9PUV6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

79929:MTBMA RS07375
gene id: 79929:MTBMA_RS07375
uniprot id: P58815
names: Cofactor
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid (PubMed:27467699). Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state (By similarity).
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.
messages: The alpha subunit contains six modified amino acids near the active site region. Is methylated on His-260, Arg-274, Gln-402 and Cys-454, probably by the action of specific S-adenosylmethionine-dependent methyltransferases. Also contains a thioglycine at position 447, forming a thiopeptide bond. Contains a didehydroaspartate residue at position 452 (PubMed:27467699). The methylation on C5 of Arg-274 is a post-translational methylation not essential in vivo, but which plays a role for the stability and structural integrity of MCR (By similarity).
messages: There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contain mostly MCR I.

79929:MTBMA RS03005
gene id: 79929:MTBMA_RS03005
uniprot id: Q60036
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Binds 1 Fe cation per subunit.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homotetramer.

79929:MTBMA RS00230
gene id: 79929:MTBMA_RS00230
uniprot id: D9PYW1
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

79929:MTBMA RS05880
gene id: 79929:MTBMA_RS05880
uniprot id: D9PX47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

79929:MTBMA RS01155
gene id: 79929:MTBMA_RS01155
uniprot id: P26923
names: Function
names: Subunit
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).

79929:MTBMA RS06165
gene id: 79929:MTBMA_RS06165
uniprot id: D9PXA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

79929:MTBMA RS08660
gene id: 79929:MTBMA_RS08660
uniprot id: D9PYP3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS00150
gene id: 79929:MTBMA_RS00150
uniprot id: D9PYU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

79929:MTBMA RS02665
gene id: 79929:MTBMA_RS02665
uniprot id: Q53479
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FPP/GGPP synthase family.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

79929:MTBMA RS06600
gene id: 79929:MTBMA_RS06600
uniprot id: D9PXJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

79929:MTBMA RS05110
gene id: 79929:MTBMA_RS05110
uniprot id: D9PWP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

79929:MTBMA RS00465
gene id: 79929:MTBMA_RS00465
uniprot id: D9PU07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

79929:MTBMA RS06245
gene id: 79929:MTBMA_RS06245
uniprot id: D9PXC0
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

79929:MTBMA RS02150
gene id: 79929:MTBMA_RS02150
uniprot id: D9PUZ0
names: Similarity
messages: Belongs to the UPF0288 family.

79929:MTBMA RS05755
gene id: 79929:MTBMA_RS05755
uniprot id: D9PX24
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

79929:MTBMA RS07610
gene id: 79929:MTBMA_RS07610
uniprot id: D9PY40
names: Similarity
messages: Belongs to the ComB family.

79929:MTBMA RS01045
gene id: 79929:MTBMA_RS01045
uniprot id: D9PUC3
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

79929:MTBMA RS08335
gene id: 79929:MTBMA_RS08335
uniprot id: O33174
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Prefers hypoxanthine, has 66% activity with guanine while activity with adenine, xanthine, uracil, orotate, or cytosine is negligible.
messages: Cytoplasm
messages: Homodimer.

79929:MTBMA RS08020
gene id: 79929:MTBMA_RS08020
uniprot id: D9PYC3
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS08350
gene id: 79929:MTBMA_RS08350
uniprot id: D9PYI0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

79929:MTBMA RS07680
gene id: 79929:MTBMA_RS07680
uniprot id: D9PY55
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

79929:MTBMA RS03440
gene id: 79929:MTBMA_RS03440
uniprot id: D9PVP6
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

79929:MTBMA RS05015
gene id: 79929:MTBMA_RS05015
uniprot id: D9PWL9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-94 inactivates the nitrogenase reductase and regulates nitrogenase activity.

79929:MTBMA RS04380
gene id: 79929:MTBMA_RS04380
uniprot id: D9PW92
names: Similarity
messages: Belongs to the HMD family.

79929:MTBMA RS08150
gene id: 79929:MTBMA_RS08150
uniprot id: D9PYE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

79929:MTBMA RS02610
gene id: 79929:MTBMA_RS02610
uniprot id: D9PV76
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

79929:MTBMA RS08820
gene id: 79929:MTBMA_RS08820
uniprot id: D9PX49
names: Similarity
messages: Belongs to the UPF0305 family.

79929:MTBMA RS09110
gene id: 79929:MTBMA_RS09110
uniprot id: D9PVG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

79929:MTBMA RS00965
gene id: 79929:MTBMA_RS00965
uniprot id: D9PUA7
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

79929:MTBMA RS00170
gene id: 79929:MTBMA_RS00170
uniprot id: D9PYU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

79929:MTBMA RS04115
gene id: 79929:MTBMA_RS04115
uniprot id: D9PW34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

79929:MTBMA RS00345
gene id: 79929:MTBMA_RS00345
uniprot id: D9PTY1
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS03765
gene id: 79929:MTBMA_RS03765
uniprot id: D9PVW3
names: Similarity
messages: Belongs to the thymidylate kinase family.

79929:MTBMA RS01140
gene id: 79929:MTBMA_RS01140
uniprot id: D9PUE3
names: Similarity
messages: Belongs to the HupF/HypC family.

79929:MTBMA RS03730
gene id: 79929:MTBMA_RS03730
uniprot id: D9PVV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

79929:MTBMA RS03435
gene id: 79929:MTBMA_RS03435
uniprot id: D9PVP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F420-dependent NADP reductase family.
messages: Catalyzes the reduction of NADP(+) with F420H(2) via hydride transfer, and the reverse reaction, i.e. the reduction of F420 with NADPH. Probably functions in the regeneration of NADPH required in biosynthetic reactions.
messages: Homotetramer.

79929:MTBMA RS04075
gene id: 79929:MTBMA_RS04075
uniprot id: D9PW26
names: Similarity
messages: Belongs to the UPF0200 family.

79929:MTBMA RS01915
gene id: 79929:MTBMA_RS01915
uniprot id: D9PUU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

79929:MTBMA RS04720
gene id: 79929:MTBMA_RS04720
uniprot id: D9PWG1
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

79929:MTBMA RS04665
gene id: 79929:MTBMA_RS04665
uniprot id: D9PWF0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS02035
gene id: 79929:MTBMA_RS02035
uniprot id: D9PUW5
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

79929:MTBMA RS02435
gene id: 79929:MTBMA_RS02435
uniprot id: D9PV42
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

79929:MTBMA RS08185
gene id: 79929:MTBMA_RS08185
uniprot id: D9PYF0
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

79929:MTBMA RS08005
gene id: 79929:MTBMA_RS08005
uniprot id: D9PYC0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

79929:MTBMA RS06750
gene id: 79929:MTBMA_RS06750
uniprot id: D9PXM1
names: Similarity
messages: Belongs to the UPF0146 family.

79929:MTBMA RS00955
gene id: 79929:MTBMA_RS00955
uniprot id: D9PUA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

79929:MTBMA RS05670
gene id: 79929:MTBMA_RS05670
uniprot id: D9PX07
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

79929:MTBMA RS07030
gene id: 79929:MTBMA_RS07030
uniprot id: D9PXS4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

79929:MTBMA RS08880
gene id: 79929:MTBMA_RS08880
uniprot id: D9PWC8
names: Similarity
messages: Belongs to the UPF0145 family.

79929:MTBMA RS08280
gene id: 79929:MTBMA_RS08280
uniprot id: D9PYG6
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

79929:MTBMA RS02080
gene id: 79929:MTBMA_RS02080
uniprot id: D9PUX5
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Catalyzes the reduction of fumarate with reduced coenzyme M (CoM-S-H) and coenzyme B (CoB-S-H). In vitro, is able to reduces fumarate with reduced benzyl viologen, oxidize CoM-S-H and CoB-S-H to CoM-S-S-CoB with methylene blue, and reduce CoM-S-S-CoB with reduced benzyl viologen. The enzyme has specificity for the two thiol compounds as the CoB--CoM heterodisulfide reductase. The enzyme is very sensitive to oxygen.
messages: Cytoplasm
messages: Subunit B of the heterodimeric fumarate reductase of methanogenic Archaea, composed of subunits A (TfrA) and B (TfrB).

79929:MTBMA RS04840
gene id: 79929:MTBMA_RS04840
uniprot id: D9PWI5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

79929:MTBMA RS02250
gene id: 79929:MTBMA_RS02250
uniprot id: D9PV10
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

79929:MTBMA RS02300
gene id: 79929:MTBMA_RS02300
uniprot id: D9PV15
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

79929:MTBMA RS05115
gene id: 79929:MTBMA_RS05115
uniprot id: D9PWP2
names: Function
names: Similarity
messages: Belongs to the P(II) protein family.
messages: Could be involved in the regulation of nitrogen fixation.

79929:MTBMA RS05290
gene id: 79929:MTBMA_RS05290
uniprot id: D9PWS9
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS07395
gene id: 79929:MTBMA_RS07395
uniprot id: P60232
names: Cofactor
messages: Binds 12 [4Fe-4S] clusters.

79929:MTBMA RS06905
gene id: 79929:MTBMA_RS06905
uniprot id: D9PXQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

79929:MTBMA RS01095
gene id: 79929:MTBMA_RS01095
uniprot id: D9PUD4
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

79929:MTBMA RS02535
gene id: 79929:MTBMA_RS02535
uniprot id: D9PV62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

79929:MTBMA RS01495
gene id: 79929:MTBMA_RS01495
uniprot id: D9PUL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

79929:MTBMA RS03150
gene id: 79929:MTBMA_RS03150
uniprot id: D9PVI7
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate. Can use NAD(+) and NADP(+) with similar specific activity.

79929:MTBMA RS08135
gene id: 79929:MTBMA_RS08135
uniprot id: D9PYE0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

79929:MTBMA RS05700
gene id: 79929:MTBMA_RS05700
uniprot id: P51616
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm
messages: Homodimer.

79929:MTBMA RS08295
gene id: 79929:MTBMA_RS08295
uniprot id: D9PYG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

79929:MTBMA RS05140
gene id: 79929:MTBMA_RS05140
uniprot id: D9PWP7
names: Similarity
messages: Belongs to the HisA/HisF family.

79929:MTBMA RS07720
gene id: 79929:MTBMA_RS07720
uniprot id: D9PY63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

79929:MTBMA RS01265
gene id: 79929:MTBMA_RS01265
uniprot id: D9PUG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

79929:MTBMA RS03315
gene id: 79929:MTBMA_RS03315
uniprot id: D9PVM1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

79929:MTBMA RS02930
gene id: 79929:MTBMA_RS02930
uniprot id: D9PVE3
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.

79929:MTBMA RS00655
gene id: 79929:MTBMA_RS00655
uniprot id: D9PU45
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.

79929:MTBMA RS05845
gene id: 79929:MTBMA_RS05845
uniprot id: D9PX40
names: Similarity
messages: Belongs to the aspartokinase family.

79929:MTBMA RS01330
gene id: 79929:MTBMA_RS01330
uniprot id: D9PUI1
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

79929:MTBMA RS03095
gene id: 79929:MTBMA_RS03095
uniprot id: D9PVH6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

79929:MTBMA RS05190
gene id: 79929:MTBMA_RS05190
uniprot id: D9PWQ9
names: Similarity
messages: Belongs to the UPF0440 family.

79929:MTBMA RS07700
gene id: 79929:MTBMA_RS07700
uniprot id: D9PY59
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

79929:MTBMA RS02125
gene id: 79929:MTBMA_RS02125
uniprot id: D9PUY4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS02645
gene id: 79929:MTBMA_RS02645
uniprot id: D9PV82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

79929:MTBMA RS07130
gene id: 79929:MTBMA_RS07130
uniprot id: D9PXU1
names: Similarity
messages: Belongs to the HypD family.

79929:MTBMA RS02580
gene id: 79929:MTBMA_RS02580
uniprot id: D9PV70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

79929:MTBMA RS05330
gene id: 79929:MTBMA_RS05330
uniprot id: P80908
names: Subunit
messages: Heterotrimer of the VorA, VorB and VorC subunits.

79929:MTBMA RS07380
gene id: 79929:MTBMA_RS07380
uniprot id: P58816
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.
messages: There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contain mostly MCR I.

79929:MTBMA RS03895
gene id: 79929:MTBMA_RS03895
uniprot id: D9PVZ0
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS04750
gene id: 79929:MTBMA_RS04750
uniprot id: D9PWG7
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS06160
gene id: 79929:MTBMA_RS06160
uniprot id: D9PXA3
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

79929:MTBMA RS01255
gene id: 79929:MTBMA_RS01255
uniprot id: D9PUG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

79929:MTBMA RS01060
gene id: 79929:MTBMA_RS01060
uniprot id: D9PUC6
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

79929:MTBMA RS01800
gene id: 79929:MTBMA_RS01800
uniprot id: D9PUR7
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.

79929:MTBMA RS05205
gene id: 79929:MTBMA_RS05205
uniprot id: D9PWR2
names: Function
messages: Probably involved in the biogenesis of the ribosome.

79929:MTBMA RS00675
gene id: 79929:MTBMA_RS00675
uniprot id: D9PU49
names: Similarity
messages: In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

79929:MTBMA RS05245
gene id: 79929:MTBMA_RS05245
uniprot id: D9PWS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

79929:MTBMA RS07050
gene id: 79929:MTBMA_RS07050
uniprot id: D9PXS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

79929:MTBMA RS05475
gene id: 79929:MTBMA_RS05475
uniprot id: D9PWW9
names: Similarity
messages: Belongs to the UPF0280 family.

79929:MTBMA RS07550
gene id: 79929:MTBMA_RS07550
uniprot id: P11558
names: Activity Regulation
names: Cofactor
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid (PubMed:3350018, PubMed:9367957). Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state (PubMed:9030728).
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis (PubMed:2269306, PubMed:3350018, PubMed:27140643). Neither N-6-mercaptohexanoylthreonine phosphate (H-S-HxoTP) nor N-8-mercaptooctanoylthreonine phosphate (H-SOcoTP) nor any other thiol compound such as CoA or CoM can substitute for CoB as the electron donor (PubMed:3350018).
messages: Cytoplasm
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.
messages: Methyl-coenzyme M reductase activity is inhibited by 3-nitrooxypropanol (3-NOP) in vitro and in vivo, by oxidation of its active site Ni(I), which stops both growth and methanogenesis (PubMed:27140643). Is also inhibited by the reaction product CoM-S-S-CoB (PubMed:3350018).
messages: The MCR reaction has been shown to follow an ordered bi-bi ternary complex mechanism, in which methyl-SCoM must enter the MCR active site prior to CoB for a productive catalysis.
messages: The alpha subunit contains six modified amino acids near the active site region (PubMed:27467699). Is methylated on His-257, Arg-271, Gln-400 and Cys-452, probably by the action of specific S-adenosylmethionine-dependent methyltransferases. Also contains a thioglycine at position 445, forming a thiopeptide bond (PubMed:10660523, PubMed:9367957, PubMed:11491299, PubMed:20707311, PubMed:21438550, PubMed:27467699). Contains a didehydroaspartate residue at position 450 (PubMed:27467699). The methylation on C5 of Arg-271 is a post-translational methylation not essential in vivo, but which plays a role for the stability and structural integrity of MCR (By similarity).
messages: There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contain mostly MCR I.

79929:MTBMA RS00010
gene id: 79929:MTBMA_RS00010
uniprot id: D9PYR9
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

79929:MTBMA RS08605
gene id: 79929:MTBMA_RS08605
uniprot id: P26499
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

79929:MTBMA RS02625
gene id: 79929:MTBMA_RS02625
uniprot id: D9PV78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

79929:MTBMA RS00110
gene id: 79929:MTBMA_RS00110
uniprot id: D9PYT7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

79929:MTBMA RS00900
gene id: 79929:MTBMA_RS00900
uniprot id: D9PU93
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS07515
gene id: 79929:MTBMA_RS07515
uniprot id: Q50774
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: Part of the probable mtrEDCBAFGH operon.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

79929:MTBMA RS00590
gene id: 79929:MTBMA_RS00590
uniprot id: D9PU32
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

79929:MTBMA RS02115
gene id: 79929:MTBMA_RS02115
uniprot id: D9PUY2
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS05895
gene id: 79929:MTBMA_RS05895
uniprot id: D9PX50
names: Similarity
messages: Belongs to the UPF0305 family.

79929:MTBMA RS00720
gene id: 79929:MTBMA_RS00720
uniprot id: Q50786
names: Function
names: Similarity
messages: Belongs to the P(II) protein family.
messages: Could be involved in the regulation of nitrogen fixation.

79929:MTBMA RS02430
gene id: 79929:MTBMA_RS02430
uniprot id: D9PV41
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

79929:MTBMA RS07590
gene id: 79929:MTBMA_RS07590
uniprot id: D9PY36
names: Similarity
messages: Belongs to the UPF0251 family.

79929:MTBMA RS05940
gene id: 79929:MTBMA_RS05940
uniprot id: D9PX60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

79929:MTBMA RS06565
gene id: 79929:MTBMA_RS06565
uniprot id: D9PXI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

79929:MTBMA RS07280
gene id: 79929:MTBMA_RS07280
uniprot id: D9PXX4
names: Similarity
messages: Belongs to the LarC family.

79929:MTBMA RS03305
gene id: 79929:MTBMA_RS03305
uniprot id: D9PVL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclic 2,3-diphosphoglycerate synthetase family.
messages: Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP.
messages: Cytoplasm

79929:MTBMA RS03100
gene id: 79929:MTBMA_RS03100
uniprot id: P0C0K9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

79929:MTBMA RS03490
gene id: 79929:MTBMA_RS03490
uniprot id: D9PVQ6
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

79929:MTBMA RS03485
gene id: 79929:MTBMA_RS03485
uniprot id: D9PVQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

79929:MTBMA RS07460
gene id: 79929:MTBMA_RS07460
uniprot id: D9PY11
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

79929:MTBMA RS03270
gene id: 79929:MTBMA_RS03270
uniprot id: D9PVL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

79929:MTBMA RS07910
gene id: 79929:MTBMA_RS07910
uniprot id: D9PYA1
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

79929:MTBMA RS03040
gene id: 79929:MTBMA_RS03040
uniprot id: D9PVG5
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

79929:MTBMA RS08705
gene id: 79929:MTBMA_RS08705
uniprot id: D9PYQ2
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

79929:MTBMA RS02855
gene id: 79929:MTBMA_RS02855
uniprot id: Q50799
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

79929:MTBMA RS07525
gene id: 79929:MTBMA_RS07525
uniprot id: P80184
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: Part of the probable mtrEDCBAFGH operon.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

79929:MTBMA RS06490
gene id: 79929:MTBMA_RS06490
uniprot id: D9PXG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 2 family.
messages: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

79929:MTBMA RS01710
gene id: 79929:MTBMA_RS01710
uniprot id: D9PUQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

79929:MTBMA RS05215
gene id: 79929:MTBMA_RS05215
uniprot id: D9PWR4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

79929:MTBMA RS07635
gene id: 79929:MTBMA_RS07635
uniprot id: D9PY45
names: Similarity
messages: Belongs to the UPF0045 family.

79929:MTBMA RS02950
gene id: 79929:MTBMA_RS02950
uniprot id: D9PVE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

79929:MTBMA RS05995
gene id: 79929:MTBMA_RS05995
uniprot id: D9PX70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

79929:MTBMA RS01890
gene id: 79929:MTBMA_RS01890
uniprot id: D9PUT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Probably functions as a manganese efflux pump.

79929:MTBMA RS02500
gene id: 79929:MTBMA_RS02500
uniprot id: D9PV55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

79929:MTBMA RS00725
gene id: 79929:MTBMA_RS00725
uniprot id: Q50787
names: Function
names: Similarity
messages: Belongs to the P(II) protein family.
messages: Could be involved in the regulation of nitrogen fixation.

79929:MTBMA RS01855
gene id: 79929:MTBMA_RS01855
uniprot id: D9PUS9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

79929:MTBMA RS02585
gene id: 79929:MTBMA_RS02585
uniprot id: D9PV71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

79929:MTBMA RS03535
gene id: 79929:MTBMA_RS03535
uniprot id: D9PVR5
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

79929:MTBMA RS03030
gene id: 79929:MTBMA_RS03030
uniprot id: D9PVG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

79929:MTBMA RS08590
gene id: 79929:MTBMA_RS08590
uniprot id: D9PYM9
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS02470
gene id: 79929:MTBMA_RS02470
uniprot id: D9PV49
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

79929:MTBMA RS01075
gene id: 79929:MTBMA_RS01075
uniprot id: D9PUC9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

79929:MTBMA RS00585
gene id: 79929:MTBMA_RS00585
uniprot id: D9PU31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

79929:MTBMA RS03230
gene id: 79929:MTBMA_RS03230
uniprot id: D9PVK3
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

79929:MTBMA RS00365
gene id: 79929:MTBMA_RS00365
uniprot id: D9PTY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

79929:MTBMA RS00995
gene id: 79929:MTBMA_RS00995
uniprot id: D9PUB3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

79929:MTBMA RS03155
gene id: 79929:MTBMA_RS03155
uniprot id: D9PVI8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

79929:MTBMA RS00250
gene id: 79929:MTBMA_RS00250
uniprot id: P55300
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Activity requires salt; 100 mM sodium or potassium salts of chloride, phosphate or sulfate are equally effective. Not inactivated by O(2). Inhibited by hydrogen-producing 5,10-methenyltetrahydromethanopterin hydrogenase which has a higher affinity for their shared substrate (PubMed:1765081). Enzyme is O(2)-stable and strictly dependent on coenzyme F420 (PubMed:7852356).
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.
messages: Enzyme activity is not detectable when grown anaerobically.
messages: Found to be tightly associated with methyl-coenzyme M methylreductase.

79929:MTBMA RS00990
gene id: 79929:MTBMA_RS00990
uniprot id: D9PUB2
names: Similarity
messages: Belongs to the PDCD5 family.

79929:MTBMA RS01250
gene id: 79929:MTBMA_RS01250
uniprot id: D9PUG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

79929:MTBMA RS01760
gene id: 79929:MTBMA_RS01760
uniprot id: D9PUQ9
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS09020
gene id: 79929:MTBMA_RS09020
uniprot id: P80183
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: Part of the probable mtrEDCBAFGH operon.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

79929:MTBMA RS02425
gene id: 79929:MTBMA_RS02425
uniprot id: D9PV40
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

79929:MTBMA RS01275
gene id: 79929:MTBMA_RS01275
uniprot id: D9PUH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

79929:MTBMA RS02325
gene id: 79929:MTBMA_RS02325
uniprot id: D9PV20
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS08385
gene id: 79929:MTBMA_RS08385
uniprot id: D9PYI7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS06635
gene id: 79929:MTBMA_RS06635
uniprot id: D9PXJ8
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

79929:MTBMA RS03540
gene id: 79929:MTBMA_RS03540
uniprot id: D9PVR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

79929:MTBMA RS02565
gene id: 79929:MTBMA_RS02565
uniprot id: D9PV68
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

79929:MTBMA RS00885
gene id: 79929:MTBMA_RS00885
uniprot id: D9PU90
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

79929:MTBMA RS03460
gene id: 79929:MTBMA_RS03460
uniprot id: D9PVQ0
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

79929:MTBMA RS03045
gene id: 79929:MTBMA_RS03045
uniprot id: D9PVG6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

79929:MTBMA RS07535
gene id: 79929:MTBMA_RS07535
uniprot id: P80185
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: Part of the probable mtrEDCBAFGH operon.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

79929:MTBMA RS09025
gene id: 79929:MTBMA_RS09025
uniprot id: P80186
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.
messages: The first gene of the probable mtrEDCBAFGH operon.

79929:MTBMA RS06265
gene id: 79929:MTBMA_RS06265
uniprot id: D9PXC5
names: Similarity
messages: Belongs to the UPF0292 family.

79929:MTBMA RS03410
gene id: 79929:MTBMA_RS03410
uniprot id: D9PVP0
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

79929:MTBMA RS04715
gene id: 79929:MTBMA_RS04715
uniprot id: D9PWG0
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

79929:MTBMA RS02915
gene id: 79929:MTBMA_RS02915
uniprot id: D9PVE0
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

79929:MTBMA RS05455
gene id: 79929:MTBMA_RS05455
uniprot id: D9PWW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
messages: Homodimer.

79929:MTBMA RS04215
gene id: 79929:MTBMA_RS04215
uniprot id: D9PW57
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

79929:MTBMA RS05860
gene id: 79929:MTBMA_RS05860
uniprot id: D9PX43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

79929:MTBMA RS02835
gene id: 79929:MTBMA_RS02835
uniprot id: D9PVC4
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

79929:MTBMA RS06785
gene id: 79929:MTBMA_RS06785
uniprot id: D9PXM8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

79929:MTBMA RS02195
gene id: 79929:MTBMA_RS02195
uniprot id: D9PUZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

79929:MTBMA RS05925
gene id: 79929:MTBMA_RS05925
uniprot id: D9PX57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

79929:MTBMA RS01160
gene id: 79929:MTBMA_RS01160
uniprot id: P26939
names: Similarity
messages: Belongs to the TrpC family.

79929:MTBMA RS02445
gene id: 79929:MTBMA_RS02445
uniprot id: D9PV44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

79929:MTBMA RS02550
gene id: 79929:MTBMA_RS02550
uniprot id: D9PV65
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS07570
gene id: 79929:MTBMA_RS07570
uniprot id: P11560
names: Activity Regulation
names: Cofactor
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid (PubMed:3350018, PubMed:9367957). Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state (PubMed:9030728).
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis (PubMed:2269306, PubMed:3350018). Neither N-6-mercaptohexanoylthreonine phosphate (H-S-HxoTP) nor N-8-mercaptooctanoylthreonine phosphate (H-SOcoTP) nor any other thiol compound such as CoA or CoM can substitute for CoB as the electron donor (PubMed:3350018).
messages: Cytoplasm
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.
messages: Methyl-coenzyme M reductase activity is inhibited by 3-nitrooxypropanol (3-NOP) in vitro and in vivo, by oxidation of its active site Ni(I), which stops both growth and methanogenesis (PubMed:27140643). Is also inhibited by the reaction product CoM-S-S-CoB (PubMed:3350018).
messages: The MCR reaction has been shown to follow an ordered bi-bi ternary complex mechanism, in which methyl-SCoM must enter the MCR active site prior to CoB for a productive catalysis.
messages: There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contain mostly MCR I.

79929:MTBMA RS00625
gene id: 79929:MTBMA_RS00625
uniprot id: D9PU39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

79929:MTBMA RS08690
gene id: 79929:MTBMA_RS08690
uniprot id: D9PYP9
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

79929:MTBMA RS00980
gene id: 79929:MTBMA_RS00980
uniprot id: D9PUB0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

79929:MTBMA RS02440
gene id: 79929:MTBMA_RS02440
uniprot id: D9PV43
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

79929:MTBMA RS02135
gene id: 79929:MTBMA_RS02135
uniprot id: D9PUY7
names: Caution
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

79929:MTBMA RS02220
gene id: 79929:MTBMA_RS02220
uniprot id: Q50755
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrB family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC. It forms a complex with the F420-non-reducing hydrogenase (Mvh), which provides the reducing equivalents to the heterodisulfide reductase.

79929:MTBMA RS07870
gene id: 79929:MTBMA_RS07870
uniprot id: D9PY94
names: Cofactor
messages: Binds 1 zinc ion per subunit.

79929:MTBMA RS08630
gene id: 79929:MTBMA_RS08630
uniprot id: P50436
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

79929:MTBMA RS00070
gene id: 79929:MTBMA_RS00070
uniprot id: D9PYT1
names: Similarity
messages: Belongs to the UPF0284 family.

79929:MTBMA RS05665
gene id: 79929:MTBMA_RS05665
uniprot id: D9PX06
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

79929:MTBMA RS08070
gene id: 79929:MTBMA_RS08070
uniprot id: D9PYD3
names: Function
messages: Part of a potassium transport system.

79929:MTBMA RS04815
gene id: 79929:MTBMA_RS04815
uniprot id: D9PWI0
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.

79929:MTBMA RS03060
gene id: 79929:MTBMA_RS03060
uniprot id: D9PVG9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

79929:MTBMA RS06540
gene id: 79929:MTBMA_RS06540
uniprot id: D9PXH9
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

79929:MTBMA RS00855
gene id: 79929:MTBMA_RS00855
uniprot id: D9PU84
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

79929:MTBMA RS05830
gene id: 79929:MTBMA_RS05830
uniprot id: D9PX37
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS08315
gene id: 79929:MTBMA_RS08315
uniprot id: D9PYH3
names: Similarity
messages: Belongs to the UPF0215 family.

79929:MTBMA RS06080
gene id: 79929:MTBMA_RS06080
uniprot id: D9PX87
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

79929:MTBMA RS02460
gene id: 79929:MTBMA_RS02460
uniprot id: D9PV47
names: Similarity
messages: Belongs to the SUI1 family.

79929:MTBMA RS03500
gene id: 79929:MTBMA_RS03500
uniprot id: D9PVQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

79929:MTBMA RS06930
gene id: 79929:MTBMA_RS06930
uniprot id: D9PXQ7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

79929:MTBMA RS03530
gene id: 79929:MTBMA_RS03530
uniprot id: D9PVR4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

79929:MTBMA RS00875
gene id: 79929:MTBMA_RS00875
uniprot id: D9PU88
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

79929:MTBMA RS05865
gene id: 79929:MTBMA_RS05865
uniprot id: D9PX44
names: Similarity
messages: Belongs to the peptidase S49 family.

79929:MTBMA RS02105
gene id: 79929:MTBMA_RS02105
uniprot id: D9PUY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

79929:MTBMA RS02090
gene id: 79929:MTBMA_RS02090
uniprot id: P80911
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

79929:MTBMA RS08755
gene id: 79929:MTBMA_RS08755
uniprot id: D9PYR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

79929:MTBMA RS05440
gene id: 79929:MTBMA_RS05440
uniprot id: D9PWW2
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS03255
gene id: 79929:MTBMA_RS03255
uniprot id: D9PVK8
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

79929:MTBMA RS04395
gene id: 79929:MTBMA_RS04395
uniprot id: D9PW95
names: Similarity
messages: Belongs to the UPF0145 family.

79929:MTBMA RS08355
gene id: 79929:MTBMA_RS08355
uniprot id: D9PYI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

79929:MTBMA RS02555
gene id: 79929:MTBMA_RS02555
uniprot id: D9PV66
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

79929:MTBMA RS00705
gene id: 79929:MTBMA_RS00705
uniprot id: Q59579
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the FwdC/FmdC family.
messages: By growth on tungsten or molybdenum under anaerobic conditions.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). Can only oxidize formylmethanofuran. This enzyme is oxygen-labile.
messages: This enzyme is composed of seven subunits FwdA (65 kDa), FwdB (53 kDa), FwdC (31 kDa), FwdD (15 kDa), FwdE, FwdF and FwdG.

79929:MTBMA RS02310
gene id: 79929:MTBMA_RS02310
uniprot id: D9PV17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

79929:MTBMA RS05260
gene id: 79929:MTBMA_RS05260
uniprot id: D9PWS3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

79929:MTBMA RS02465
gene id: 79929:MTBMA_RS02465
uniprot id: D9PV48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

79929:MTBMA RS01110
gene id: 79929:MTBMA_RS01110
uniprot id: D9PUD7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

79929:MTBMA RS03240
gene id: 79929:MTBMA_RS03240
uniprot id: D9PVK5
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

79929:MTBMA RS00645
gene id: 79929:MTBMA_RS00645
uniprot id: D9PU43
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

79929:MTBMA RS04590
gene id: 79929:MTBMA_RS04590
uniprot id: D9PWD4
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS00445
gene id: 79929:MTBMA_RS00445
uniprot id: D9PU03
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

79929:MTBMA RS06280
gene id: 79929:MTBMA_RS06280
uniprot id: D9PXC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

79929:MTBMA RS07710
gene id: 79929:MTBMA_RS07710
uniprot id: D9PY61
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

79929:MTBMA RS01320
gene id: 79929:MTBMA_RS01320
uniprot id: D9PUH9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
messages: Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
messages: Cell membrane

79929:MTBMA RS01270
gene id: 79929:MTBMA_RS01270
uniprot id: D9PUG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

79929:MTBMA RS00165
gene id: 79929:MTBMA_RS00165
uniprot id: D9PYU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

79929:MTBMA RS01435
gene id: 79929:MTBMA_RS01435
uniprot id: D9PUK2
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).

79929:MTBMA RS00880
gene id: 79929:MTBMA_RS00880
uniprot id: D9PU89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

79929:MTBMA RS07520
gene id: 79929:MTBMA_RS07520
uniprot id: Q50773
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrF family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: Part of the probable mtrEDCBAFGH operon.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

79929:MTBMA RS08500
gene id: 79929:MTBMA_RS08500
uniprot id: Q50497
names: Cofactor
names: Domain
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Binds 1 FMN per subunit.
messages: Binds 2 iron ions per subunit.
messages: By iron limitation.
messages: Catalyzes the oxidation of F420H(2) with O(2) (PubMed:15340796, PubMed:16218963). May be involved in O(2) detoxification, reducing the intracellular O(2) concentration to a level allowing growth at the expense of methane formation (PubMed:15340796).
messages: Contains an N-terminal beta-lactamase-like domain harboring a di-iron center, and a C-terminal flavodoxin-like domain containing FMN. Two monomers assemble via a head-to-tail arrangement, such that the beta-lactamase and the flavodoxin domains face each other, thereby forming two separated and presumably independent active sites.
messages: Homodimer (PubMed:7649162). Homotetramer (PubMed:7730275, PubMed:17480207). The tetramer is composed of two functional dimers (PubMed:17480207).
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

79929:MTBMA RS06775
gene id: 79929:MTBMA_RS06775
uniprot id: D9PXM6
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

79929:MTBMA RS05970
gene id: 79929:MTBMA_RS05970
uniprot id: D9PX65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

79929:MTBMA RS03465
gene id: 79929:MTBMA_RS03465
uniprot id: D9PVQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

79929:MTBMA RS04855
gene id: 79929:MTBMA_RS04855
uniprot id: D9PWI8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

79929:MTBMA RS05345
gene id: 79929:MTBMA_RS05345
uniprot id: D9PWU1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

79929:MTBMA RS05275
gene id: 79929:MTBMA_RS05275
uniprot id: D9PWS6
names: Similarity
messages: Belongs to the band 7/mec-2 family.

79929:MTBMA RS05030
gene id: 79929:MTBMA_RS05030
uniprot id: D9PWM2
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

79929:MTBMA RS00275
gene id: 79929:MTBMA_RS00275
uniprot id: D9PYX0
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS02650
gene id: 79929:MTBMA_RS02650
uniprot id: D9PV83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

79929:MTBMA RS04650
gene id: 79929:MTBMA_RS04650
uniprot id: D9PWE7
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

79929:MTBMA RS04990
gene id: 79929:MTBMA_RS04990
uniprot id: D9PWL6
names: Similarity
messages: Belongs to the UPF0235 family.

79929:MTBMA RS07725
gene id: 79929:MTBMA_RS07725
uniprot id: D9PY64
names: Similarity
messages: Belongs to the LDH2/MDH2 oxidoreductase family.

79929:MTBMA RS01405
gene id: 79929:MTBMA_RS01405
uniprot id: D9PUJ6
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS07270
gene id: 79929:MTBMA_RS07270
uniprot id: D9PXX2
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS06215
gene id: 79929:MTBMA_RS06215
uniprot id: D9PXB4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS01090
gene id: 79929:MTBMA_RS01090
uniprot id: D9PUD2
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine.

79929:MTBMA RS03130
gene id: 79929:MTBMA_RS03130
uniprot id: D9PVI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

79929:MTBMA RS00840
gene id: 79929:MTBMA_RS00840
uniprot id: D9PU81
names: Similarity
messages: Belongs to the phosphohexose mutase family.

79929:MTBMA RS04610
gene id: 79929:MTBMA_RS04610
uniprot id: P0C882
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Homopentamer.
messages: Inhibited by EDTA in vitro.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. Cannot use sn-glycerol-3-phosphate (G3P) or dihydroxyacetonephosphate (DHAP) as substrate.

79929:MTBMA RS09115
gene id: 79929:MTBMA_RS09115
uniprot id: D9PYB7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

79929:MTBMA RS02510
gene id: 79929:MTBMA_RS02510
uniprot id: D9PV57
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

79929:MTBMA RS01500
gene id: 79929:MTBMA_RS01500
uniprot id: D9PUL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

79929:MTBMA RS02935
gene id: 79929:MTBMA_RS02935
uniprot id: D9PVE4
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS08700
gene id: 79929:MTBMA_RS08700
uniprot id: D9PYQ1
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

79929:MTBMA RS00730
gene id: 79929:MTBMA_RS00730
uniprot id: Q50788
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Binds 1 [7Fe-Mo-9S-C-homocitryl] cluster per subunit.
messages: Binds 1 [8Fe-7S] cluster per heterodimer.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

79929:MTBMA RS04020
gene id: 79929:MTBMA_RS04020
uniprot id: D9PW15
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS05280
gene id: 79929:MTBMA_RS05280
uniprot id: D9PWS7
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS06840
gene id: 79929:MTBMA_RS06840
uniprot id: D9PXN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.

79929:MTBMA RS01040
gene id: 79929:MTBMA_RS01040
uniprot id: D9PUC2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

79929:MTBMA RS06060
gene id: 79929:MTBMA_RS06060
uniprot id: D9PX83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

79929:MTBMA RS08325
gene id: 79929:MTBMA_RS08325
uniprot id: D9PYH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

79929:MTBMA RS01665
gene id: 79929:MTBMA_RS01665
uniprot id: D9PUP1
names: Function
names: Similarity
messages: Belongs to the trehalose phosphatase family.
messages: Removes the phosphate from trehalose 6-phosphate to produce free trehalose.

79929:MTBMA RS07400
gene id: 79929:MTBMA_RS07400
uniprot id: P60227
names: Function
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
messages: Part of a complex that provides reducing equivalents for heterodisulfide reductase.
messages: The F420-non-reducing hydrogenase is composed of three subunits; MvhA, MvhD and MvhG. It forms a complex with the heterodisulfide reductase (hdr).

79929:MTBMA RS04850
gene id: 79929:MTBMA_RS04850
uniprot id: D9PWI7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm
messages: Homooctamer.

79929:MTBMA RS08090
gene id: 79929:MTBMA_RS08090
uniprot id: D9PYD6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

79929:MTBMA RS06845
gene id: 79929:MTBMA_RS06845
uniprot id: D9PXP0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
messages: Homodimer.
messages: Monovalent cation. The ion could be potassium.

79929:MTBMA RS05150
gene id: 79929:MTBMA_RS05150
uniprot id: D9PWP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

79929:MTBMA RS02590
gene id: 79929:MTBMA_RS02590
uniprot id: D9PV72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

79929:MTBMA RS05235
gene id: 79929:MTBMA_RS05235
uniprot id: D9PWR8
names: Similarity
messages: Belongs to the SDO1/SBDS family.

79929:MTBMA RS06455
gene id: 79929:MTBMA_RS06455
uniprot id: D9PXG2
names: Similarity
messages: Belongs to the DtxR/MntR family.

79929:MTBMA RS06170
gene id: 79929:MTBMA_RS06170
uniprot id: D9PXA5
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

79929:MTBMA RS06555
gene id: 79929:MTBMA_RS06555
uniprot id: D9PXI2
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

79929:MTBMA RS02085
gene id: 79929:MTBMA_RS02085
uniprot id: P80910
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

79929:MTBMA RS02910
gene id: 79929:MTBMA_RS02910
uniprot id: D9PVD9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

79929:MTBMA RS08640
gene id: 79929:MTBMA_RS08640
uniprot id: D9PYN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

79929:MTBMA RS06880
gene id: 79929:MTBMA_RS06880
uniprot id: D9PXP7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

79929:MTBMA RS02985
gene id: 79929:MTBMA_RS02985
uniprot id: D9PVF4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

79929:MTBMA RS08030
gene id: 79929:MTBMA_RS08030
uniprot id: D9PYC5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS03175
gene id: 79929:MTBMA_RS03175
uniprot id: D9PVJ2
names: Similarity
messages: Belongs to the glutamate synthase family.

79929:MTBMA RS06915
gene id: 79929:MTBMA_RS06915
uniprot id: P80904
names: Subunit
messages: Heterotetramer of the KorA, KorB, KorC and KorD subunits.

79929:MTBMA RS08170
gene id: 79929:MTBMA_RS08170
uniprot id: D9PYE7
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

79929:MTBMA RS02315
gene id: 79929:MTBMA_RS02315
uniprot id: D9PV19
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS04625
gene id: 79929:MTBMA_RS04625
uniprot id: D9PWE1
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

79929:MTBMA RS05050
gene id: 79929:MTBMA_RS05050
uniprot id: D9PWM7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the creatininase superfamily. FAPy deformylase family.
messages: Catalyzes the hydrolysis of the formamide of 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy).
messages: Homodimer.
messages: Requires an additional second metal ion that could be Fe(2+) or Zn(2+).
messages: Requires one Fe(2+) ion for activity.

79929:MTBMA RS07560
gene id: 79929:MTBMA_RS07560
uniprot id: P11566
names: Developmental Stage
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.
messages: There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contains mostly MCR I.

79929:MTBMA RS04690
gene id: 79929:MTBMA_RS04690
uniprot id: D9PWF5
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

79929:MTBMA RS06030
gene id: 79929:MTBMA_RS06030
uniprot id: D9PX77
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS05480
gene id: 79929:MTBMA_RS05480
uniprot id: D9PWX0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

79929:MTBMA RS01395
gene id: 79929:MTBMA_RS01395
uniprot id: D9PUJ4
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS07640
gene id: 79929:MTBMA_RS07640
uniprot id: D9PY46
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

79929:MTBMA RS01545
gene id: 79929:MTBMA_RS01545
uniprot id: P80901
names: Cofactor
names: Subunit
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

79929:MTBMA RS07295
gene id: 79929:MTBMA_RS07295
uniprot id: D9PXX7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

79929:MTBMA RS02640
gene id: 79929:MTBMA_RS02640
uniprot id: D9PV81
names: Similarity
messages: Belongs to the MEMO1 family.

79929:MTBMA RS00260
gene id: 79929:MTBMA_RS00260
uniprot id: D9PYW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

79929:MTBMA RS06585
gene id: 79929:MTBMA_RS06585
uniprot id: D9PXI8
names: Similarity
messages: Belongs to the class-I fumarase family.

79929:MTBMA RS06690
gene id: 79929:MTBMA_RS06690
uniprot id: D9PXK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

79929:MTBMA RS00930
gene id: 79929:MTBMA_RS00930
uniprot id: D9PUA0
names: Similarity
messages: Belongs to the TPP enzyme family.

79929:MTBMA RS00820
gene id: 79929:MTBMA_RS00820
uniprot id: D9PU77
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

79929:MTBMA RS08065
gene id: 79929:MTBMA_RS08065
uniprot id: D9PYD2
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS01065
gene id: 79929:MTBMA_RS01065
uniprot id: D9PUC7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

79929:MTBMA RS00060
gene id: 79929:MTBMA_RS00060
uniprot id: D9PYS9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

79929:MTBMA RS02185
gene id: 79929:MTBMA_RS02185
uniprot id: D9PUZ7
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

79929:MTBMA RS01520
gene id: 79929:MTBMA_RS01520
uniprot id: D9PUL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

79929:MTBMA RS02605
gene id: 79929:MTBMA_RS02605
uniprot id: D9PV75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

79929:MTBMA RS04005
gene id: 79929:MTBMA_RS04005
uniprot id: D9PW11
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS00400
gene id: 79929:MTBMA_RS00400
uniprot id: D9PTZ3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

79929:MTBMA RS06560
gene id: 79929:MTBMA_RS06560
uniprot id: D9PXI3
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

79929:MTBMA RS05515
gene id: 79929:MTBMA_RS05515
uniprot id: D9PWX7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the small carbamoyl-phosphate synthase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Catalyzes the synthesis of carbamoyl phosphate from ATP, ammonium and bicarbonate. Proceeds via a three-step mechanism, i.e. the phosphorylation of hydrogencarbonate to carboxyphosphate, a nucleophilic attack of ammonia on carboxyphosphate yielding carbamate, and the phosphorylation of carbamate forming carbamoyl phosphate.

79929:MTBMA RS08390
gene id: 79929:MTBMA_RS08390
uniprot id: D9PYI8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

79929:MTBMA RS01150
gene id: 79929:MTBMA_RS01150
uniprot id: P26940
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Feedback inhibited by tryptophan.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).

79929:MTBMA RS02515
gene id: 79929:MTBMA_RS02515
uniprot id: D9PV58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

79929:MTBMA RS03220
gene id: 79929:MTBMA_RS03220
uniprot id: D9PVK1
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS02480
gene id: 79929:MTBMA_RS02480
uniprot id: D9PV51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

79929:MTBMA RS02980
gene id: 79929:MTBMA_RS02980
uniprot id: D9PVF3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

79929:MTBMA RS07410
gene id: 79929:MTBMA_RS07410
uniprot id: P60238
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MvhD/VhuD family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Part of a complex that provides reducing equivalents for heterodisulfide reductase. MvhD may form the contact site to heterodisulfide reductase.
messages: The F420-non-reducing hydrogenase is composed of three subunits; MvhA, MvhD and MvhG. It forms a complex with the heterodisulfide reductase (hdr).

79929:MTBMA RS08400
gene id: 79929:MTBMA_RS08400
uniprot id: D9PYJ0
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

79929:MTBMA RS03520
gene id: 79929:MTBMA_RS03520
uniprot id: D9PVR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

79929:MTBMA RS07255
gene id: 79929:MTBMA_RS07255
uniprot id: D9PXW9
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

79929:MTBMA RS06205
gene id: 79929:MTBMA_RS06205
uniprot id: D9PXB2
names: Subcellular Location Annotation
messages: Cell membrane

79929:MTBMA RS01385
gene id: 79929:MTBMA_RS01385
uniprot id: D9PUJ2
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS06370
gene id: 79929:MTBMA_RS06370
uniprot id: P61937
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subunit
messages: By growth on molybdenum, under anaerobic conditions.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). Can only oxidize formylmethanofuran. This enzyme is oxygen-labile.
messages: Consists of five subunits; FmdA, FmdB, FmdC, FmdD, and FmdE.
messages: In the C-terminal section; belongs to the molybdenum dinucleotide binding protein family.
messages: In the N-terminal section; belongs to the FwdC/FmdC family.
messages: Inactivated by cyanide.

79929:MTBMA RS07705
gene id: 79929:MTBMA_RS07705
uniprot id: D9PY60
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

79929:MTBMA RS03350
gene id: 79929:MTBMA_RS03350
uniprot id: D9PVM8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS07125
gene id: 79929:MTBMA_RS07125
uniprot id: D9PXU0
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

79929:MTBMA RS06770
gene id: 79929:MTBMA_RS06770
uniprot id: D9PXM5
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

79929:MTBMA RS05875
gene id: 79929:MTBMA_RS05875
uniprot id: D9PX46
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

79929:MTBMA RS08675
gene id: 79929:MTBMA_RS08675
uniprot id: D9PYP6
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

79929:MTBMA RS03450
gene id: 79929:MTBMA_RS03450
uniprot id: D9PVP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

79929:MTBMA RS08320
gene id: 79929:MTBMA_RS08320
uniprot id: D9PYH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

79929:MTBMA RS00085
gene id: 79929:MTBMA_RS00085
uniprot id: D9PYT4
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

79929:MTBMA RS00635
gene id: 79929:MTBMA_RS00635
uniprot id: D9PU41
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

79929:MTBMA RS03795
gene id: 79929:MTBMA_RS03795
uniprot id: D9PVW9
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS07785
gene id: 79929:MTBMA_RS07785
uniprot id: D9PY77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

79929:MTBMA RS06545
gene id: 79929:MTBMA_RS06545
uniprot id: D9PXI0
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

79929:MTBMA RS08305
gene id: 79929:MTBMA_RS08305
uniprot id: D9PYH1
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

79929:MTBMA RS07795
gene id: 79929:MTBMA_RS07795
uniprot id: D9PY79
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS06860
gene id: 79929:MTBMA_RS06860
uniprot id: D9PXP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

79929:MTBMA RS07500
gene id: 79929:MTBMA_RS07500
uniprot id: Q50777
names: Similarity
messages: Belongs to the universal stress protein A family.

79929:MTBMA RS05980
gene id: 79929:MTBMA_RS05980
uniprot id: D9PX67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Heterotetramer of 2 HacA and 2 HacB proteins.
messages: Hydro-lyase with broad substrate specificity for cis-unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4-tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B.

79929:MTBMA RS00510
gene id: 79929:MTBMA_RS00510
uniprot id: D9PU16
names: Similarity
messages: Belongs to the SfsA family.

79929:MTBMA RS03260
gene id: 79929:MTBMA_RS03260
uniprot id: D9PVK9
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS02490
gene id: 79929:MTBMA_RS02490
uniprot id: D9PV53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

79929:MTBMA RS02355
gene id: 79929:MTBMA_RS02355
uniprot id: D9PV26
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

79929:MTBMA RS02850
gene id: 79929:MTBMA_RS02850
uniprot id: D9PVC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

79929:MTBMA RS00525
gene id: 79929:MTBMA_RS00525
uniprot id: D9PU19
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

79929:MTBMA RS08340
gene id: 79929:MTBMA_RS08340
uniprot id: D9PYH8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

79929:MTBMA RS02865
gene id: 79929:MTBMA_RS02865
uniprot id: Q50801
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).

79929:MTBMA RS04705
gene id: 79929:MTBMA_RS04705
uniprot id: D9PWF8
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

79929:MTBMA RS02655
gene id: 79929:MTBMA_RS02655
uniprot id: D9PV84
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS02845
gene id: 79929:MTBMA_RS02845
uniprot id: D9PVC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

79929:MTBMA RS08645
gene id: 79929:MTBMA_RS08645
uniprot id: D9PYP0
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

79929:MTBMA RS04090
gene id: 79929:MTBMA_RS04090
uniprot id: D9PW29
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

79929:MTBMA RS08490
gene id: 79929:MTBMA_RS08490
uniprot id: D9PYK8
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

79929:MTBMA RS01300
gene id: 79929:MTBMA_RS01300
uniprot id: D9PUH5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

79929:MTBMA RS06655
gene id: 79929:MTBMA_RS06655
uniprot id: D9PXK2
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.

79929:MTBMA RS02725
gene id: 79929:MTBMA_RS02725
uniprot id: Q9C4Z5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Channel that permits osmotically driven movement of water in both directions. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Exhibits also a transient but reproducible increase in the initial glycerol flux.
messages: Homotetramer.

79929:MTBMA RS02455
gene id: 79929:MTBMA_RS02455
uniprot id: D9PV46
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

79929:MTBMA RS01365
gene id: 79929:MTBMA_RS01365
uniprot id: D9PUI8
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

79929:MTBMA RS05230
gene id: 79929:MTBMA_RS05230
uniprot id: D9PWR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

79929:MTBMA RS00145
gene id: 79929:MTBMA_RS00145
uniprot id: D9PYU4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS00905
gene id: 79929:MTBMA_RS00905
uniprot id: D9PU94
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

79929:MTBMA RS07650
gene id: 79929:MTBMA_RS07650
uniprot id: D9PY48
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

79929:MTBMA RS03495
gene id: 79929:MTBMA_RS03495
uniprot id: D9PVQ7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

79929:MTBMA RS01285
gene id: 79929:MTBMA_RS01285
uniprot id: D9PUH2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

79929:MTBMA RS02635
gene id: 79929:MTBMA_RS02635
uniprot id: D9PV80
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

79929:MTBMA RS00405
gene id: 79929:MTBMA_RS00405
uniprot id: D9PTZ4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS08275
gene id: 79929:MTBMA_RS08275
uniprot id: D9PYG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

79929:MTBMA RS00735
gene id: 79929:MTBMA_RS00735
uniprot id: P95296
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Binds 1 [8Fe-7S] cluster per heterodimer.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

79929:MTBMA RS03415
gene id: 79929:MTBMA_RS03415
uniprot id: D9PVP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

79929:MTBMA RS00920
gene id: 79929:MTBMA_RS00920
uniprot id: D9PU98
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

79929:MTBMA RS07800
gene id: 79929:MTBMA_RS07800
uniprot id: D9PY80
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

79929:MTBMA RS05365
gene id: 79929:MTBMA_RS05365
uniprot id: D9PWU6
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

79929:MTBMA RS02505
gene id: 79929:MTBMA_RS02505
uniprot id: D9PV56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

79929:MTBMA RS00810
gene id: 79929:MTBMA_RS00810
uniprot id: D9PU75
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

79929:MTBMA RS00420
gene id: 79929:MTBMA_RS00420
uniprot id: D9PTZ7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS00460
gene id: 79929:MTBMA_RS00460
uniprot id: D9PU06
names: Similarity
messages: Belongs to the CutA family.

79929:MTBMA RS07510
gene id: 79929:MTBMA_RS07510
uniprot id: P80187
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the MtrH family.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.
messages: The last gene of the probable mtrEDCBAFGH operon.

79929:MTBMA RS06835
gene id: 79929:MTBMA_RS06835
uniprot id: D9PXN8
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

79929:MTBMA RS05575
gene id: 79929:MTBMA_RS05575
uniprot id: D9PWY9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

79929:MTBMA RS00550
gene id: 79929:MTBMA_RS00550
uniprot id: D9PU23
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

79929:MTBMA RS01795
gene id: 79929:MTBMA_RS01795
uniprot id: D9PUR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

79929:MTBMA RS08610
gene id: 79929:MTBMA_RS08610
uniprot id: P26498
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

79929:MTBMA RS08760
gene id: 79929:MTBMA_RS08760
uniprot id: D9PYR3
names: Subunit
messages: Homotetramer.

79929:MTBMA RS01015
gene id: 79929:MTBMA_RS01015
uniprot id: D9PUB7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS07935
gene id: 79929:MTBMA_RS07935
uniprot id: D9PYA6
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS07025
gene id: 79929:MTBMA_RS07025
uniprot id: D9PXS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

79929:MTBMA RS01430
gene id: 79929:MTBMA_RS01430
uniprot id: D9PUK1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex.

79929:MTBMA RS03670
gene id: 79929:MTBMA_RS03670
uniprot id: D9PVU4
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS00910
gene id: 79929:MTBMA_RS00910
uniprot id: D9PU95
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

79929:MTBMA RS04250
gene id: 79929:MTBMA_RS04250
uniprot id: D9PW64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Dps family.
messages: Homododecamer. The 12 identical subunits form a hollow sphere into which the mineral iron core of up to 300 Fe(3+) can be deposited.
messages: Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction.
messages: nucleoid

79929:MTBMA RS05705
gene id: 79929:MTBMA_RS05705
uniprot id: P80305
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate. In vitro, also catalyzes the dehalogenation of 5-bromo-deoxyuridine monophosphate (Br-dUMP) and the tritium exchange of [5-3H]deoxyuridine monophosphate ([5-3H]dUMP).
messages: Monomer.

79929:MTBMA RS02860
gene id: 79929:MTBMA_RS02860
uniprot id: D9PVC9
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS06795
gene id: 79929:MTBMA_RS06795
uniprot id: D9PXN0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

79929:MTBMA RS04270
gene id: 79929:MTBMA_RS04270
uniprot id: D9PW70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

79929:MTBMA RS07420
gene id: 79929:MTBMA_RS07420
uniprot id: D9PY02
names: Similarity
messages: Belongs to the MvhD/VhuD family.

79929:MTBMA RS03055
gene id: 79929:MTBMA_RS03055
uniprot id: D9PVG8
names: Similarity
messages: Belongs to the SAICAR synthetase family.

79929:MTBMA RS00865
gene id: 79929:MTBMA_RS00865
uniprot id: D9PU86
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

79929:MTBMA RS02420
gene id: 79929:MTBMA_RS02420
uniprot id: D9PV39
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

79929:MTBMA RS01175
gene id: 79929:MTBMA_RS01175
uniprot id: P26920
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

79929:MTBMA RS02280
gene id: 79929:MTBMA_RS02280
uniprot id: D9PV11
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS04515
gene id: 79929:MTBMA_RS04515
uniprot id: D9PWB9
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

79929:MTBMA RS04175
gene id: 79929:MTBMA_RS04175
uniprot id: D9PW48
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

79929:MTBMA RS06810
gene id: 79929:MTBMA_RS06810
uniprot id: P42809
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA (By similarity).
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization (By similarity).

79929:MTBMA RS02030
gene id: 79929:MTBMA_RS02030
uniprot id: D9PUW4
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

79929:MTBMA RS07690
gene id: 79929:MTBMA_RS07690
uniprot id: D9PY57
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

79929:MTBMA RS00960
gene id: 79929:MTBMA_RS00960
uniprot id: D9PUA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

79929:MTBMA RS08225
gene id: 79929:MTBMA_RS08225
uniprot id: D9PYF7
names: Similarity
messages: Belongs to the FrhG family.

79929:MTBMA RS05760
gene id: 79929:MTBMA_RS05760
uniprot id: D9PX25
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

79929:MTBMA RS01280
gene id: 79929:MTBMA_RS01280
uniprot id: D9PUH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

79929:MTBMA RS05555
gene id: 79929:MTBMA_RS05555
uniprot id: D9PWY5
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

79929:MTBMA RS04700
gene id: 79929:MTBMA_RS04700
uniprot id: D9PWF7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

79929:MTBMA RS00870
gene id: 79929:MTBMA_RS00870
uniprot id: D9PU87
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

79929:MTBMA RS05935
gene id: 79929:MTBMA_RS05935
uniprot id: D9PX59
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

79929:MTBMA RS01390
gene id: 79929:MTBMA_RS01390
uniprot id: D9PUJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

79929:MTBMA RS01170
gene id: 79929:MTBMA_RS01170
uniprot id: P26921
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

79929:MTBMA RS01005
gene id: 79929:MTBMA_RS01005
uniprot id: D9PUB5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

79929:MTBMA RS02615
gene id: 79929:MTBMA_RS02615
uniprot id: D9PV77
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

79929:MTBMA RS01350
gene id: 79929:MTBMA_RS01350
uniprot id: D9PUI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

79929:MTBMA RS07965
gene id: 79929:MTBMA_RS07965
uniprot id: D9PYB2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

79929:MTBMA RS01345
gene id: 79929:MTBMA_RS01345
uniprot id: D9PUI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

79929:MTBMA RS08140
gene id: 79929:MTBMA_RS08140
uniprot id: D9PYE1
names: Similarity
messages: Belongs to the UPF0248 family.

79929:MTBMA RS02240
gene id: 79929:MTBMA_RS02240
uniprot id: D9PV08
names: Function
names: Similarity
messages: Belongs to the 2-phosphoglycerate kinase family.
messages: Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.

79929:MTBMA RS06885
gene id: 79929:MTBMA_RS06885
uniprot id: D9PXP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

79929:MTBMA RS00140
gene id: 79929:MTBMA_RS00140
uniprot id: D9PYU3
names: Similarity
messages: Belongs to the UPF0285 family.

79929:MTBMA RS05100
gene id: 79929:MTBMA_RS05100
uniprot id: D9PWN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

79929:MTBMA RS08600
gene id: 79929:MTBMA_RS08600
uniprot id: P26500
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

79929:MTBMA RS07390
gene id: 79929:MTBMA_RS07390
uniprot id: D9PXZ6
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.
messages: There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contain mostly MCR I.

79929:MTBMA RS03200
gene id: 79929:MTBMA_RS03200
uniprot id: D9PVJ7
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS00850
gene id: 79929:MTBMA_RS00850
uniprot id: D9PU83
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

79929:MTBMA RS06110
gene id: 79929:MTBMA_RS06110
uniprot id: D9PX93
names: Similarity
messages: Belongs to the peptidase U62 family.

79929:MTBMA RS07790
gene id: 79929:MTBMA_RS07790
uniprot id: D9PY78
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

79929:MTBMA RS06925
gene id: 79929:MTBMA_RS06925
uniprot id: P80906
names: Subunit
messages: Heterotetramer of the KorA, KorB, KorC and KorD subunits.

79929:MTBMA RS04240
gene id: 79929:MTBMA_RS04240
uniprot id: D9PW62
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

79929:MTBMA RS00650
gene id: 79929:MTBMA_RS00650
uniprot id: D9PU44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

79929:MTBMA RS02075
gene id: 79929:MTBMA_RS02075
uniprot id: D9PUX4
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

79929:MTBMA RS07740
gene id: 79929:MTBMA_RS07740
uniprot id: D9PY67
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

79929:MTBMA RS01985
gene id: 79929:MTBMA_RS01985
uniprot id: D9PUV5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

79929:MTBMA RS02735
gene id: 79929:MTBMA_RS02735
uniprot id: D9PVA1
names: Similarity
messages: Belongs to the glutamate synthase family.

79929:MTBMA RS01335
gene id: 79929:MTBMA_RS01335
uniprot id: D9PUI2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

79929:MTBMA RS07320
gene id: 79929:MTBMA_RS07320
uniprot id: D9PXY2
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

79929:MTBMA RS02335
gene id: 79929:MTBMA_RS02335
uniprot id: D9PV22
names: Similarity
messages: Belongs to the UPF0173 family.

79929:MTBMA RS00915
gene id: 79929:MTBMA_RS00915
uniprot id: D9PU97
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

79929:MTBMA RS06200
gene id: 79929:MTBMA_RS06200
uniprot id: D9PXB1
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

79929:MTBMA RS03445
gene id: 79929:MTBMA_RS03445
uniprot id: D9PVP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers.

79929:MTBMA RS06570
gene id: 79929:MTBMA_RS06570
uniprot id: D9PXI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

79929:MTBMA RS08270
gene id: 79929:MTBMA_RS08270
uniprot id: D9PYG4
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

79929:MTBMA RS08585
gene id: 79929:MTBMA_RS08585
uniprot id: D9PYM8
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS06230
gene id: 79929:MTBMA_RS06230
uniprot id: D9PXB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

79929:MTBMA RS01420
gene id: 79929:MTBMA_RS01420
uniprot id: D9PUJ9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

79929:MTBMA RS02060
gene id: 79929:MTBMA_RS02060
uniprot id: D9PUX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

79929:MTBMA RS08235
gene id: 79929:MTBMA_RS08235
uniprot id: D9PYF9
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

79929:MTBMA RS03400
gene id: 79929:MTBMA_RS03400
uniprot id: D9PVN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

79929:MTBMA RS05885
gene id: 79929:MTBMA_RS05885
uniprot id: D9PX48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

79929:MTBMA RS05805
gene id: 79929:MTBMA_RS05805
uniprot id: D9PX32
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

79929:MTBMA RS05750
gene id: 79929:MTBMA_RS05750
uniprot id: D9PX23
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

79929:MTBMA RS04410
gene id: 79929:MTBMA_RS04410
uniprot id: D9PW98
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

79929:MTBMA RS02450
gene id: 79929:MTBMA_RS02450
uniprot id: D9PV45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

79929:MTBMA RS08190
gene id: 79929:MTBMA_RS08190
uniprot id: D9PYF1
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

79929:MTBMA RS08775
gene id: 79929:MTBMA_RS08775
uniprot id: D9PYR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

79929:MTBMA RS05340
gene id: 79929:MTBMA_RS05340
uniprot id: D9PWU0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

79929:MTBMA RS05710
gene id: 79929:MTBMA_RS05710
uniprot id: P55299
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal MetE family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. Can use methylcobalamin and methylcobinamide as methyl donors, but methylcobalamin is not considered to be the physiological substrate. It was proposed that, in vivo, a so-far-unidentified enzyme catalyzes methyltransfer from 5-methyltetrahydromethanopterin (5-CH3-H4MPT) to a corrinoid protein, and that the MetE gene product catalyzes the further transfer to L-homocysteine. Is not active with L-cysteine, coenzyme M, coenzyme B, glutathione or dithiothreitol as substrate.
messages: Is activated by phosphates.

79929:MTBMA RS03510
gene id: 79929:MTBMA_RS03510
uniprot id: D9PVR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

79929:MTBMA RS02570
gene id: 79929:MTBMA_RS02570
uniprot id: D9PV69
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

79929:MTBMA RS03640
gene id: 79929:MTBMA_RS03640
uniprot id: D9PVT8
names: Similarity
messages: Belongs to the HepT RNase toxin family.

79929:MTBMA RS05850
gene id: 79929:MTBMA_RS05850
uniprot id: D9PX41
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

79929:MTBMA RS03655
gene id: 79929:MTBMA_RS03655
uniprot id: D9PVU1
names: Similarity
messages: Belongs to the HepT RNase toxin family.

79929:MTBMA RS00475
gene id: 79929:MTBMA_RS00475
uniprot id: D9PU09
names: Similarity
messages: Belongs to the HMD family.

79929:MTBMA RS00180
gene id: 79929:MTBMA_RS00180
uniprot id: D9PYV1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS07305
gene id: 79929:MTBMA_RS07305
uniprot id: D9PXX9
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS04265
gene id: 79929:MTBMA_RS04265
uniprot id: D9PW69
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS03225
gene id: 79929:MTBMA_RS03225
uniprot id: D9PVK2
names: Similarity
messages: Belongs to the HypE family.

79929:MTBMA RS07005
gene id: 79929:MTBMA_RS07005
uniprot id: D9PXR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

79929:MTBMA RS05840
gene id: 79929:MTBMA_RS05840
uniprot id: D9PX39
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

79929:MTBMA RS07505
gene id: 79929:MTBMA_RS07505
uniprot id: D9PY20
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS07010
gene id: 79929:MTBMA_RS07010
uniprot id: D9PXS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.
messages: Part of the RNA polymerase complex.

79929:MTBMA RS06270
gene id: 79929:MTBMA_RS06270
uniprot id: D9PXC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

79929:MTBMA RS00975
gene id: 79929:MTBMA_RS00975
uniprot id: D9PUA9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

79929:MTBMA RS01450
gene id: 79929:MTBMA_RS01450
uniprot id: D9PUK5
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

79929:MTBMA RS06665
gene id: 79929:MTBMA_RS06665
uniprot id: D9PXK4
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS00285
gene id: 79929:MTBMA_RS00285
uniprot id: D9PTW9
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

79929:MTBMA RS08635
gene id: 79929:MTBMA_RS08635
uniprot id: Q50756
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Binds 4 [4Fe-4S] clusters per subunit.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC. It forms a complex with the F420-non-reducing hydrogenase (Mvh), which provides the reducing equivalents to the heterodisulfide reductase.

79929:MTBMA RS00395
gene id: 79929:MTBMA_RS00395
uniprot id: D9PTZ2
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS06740
gene id: 79929:MTBMA_RS06740
uniprot id: D9PXL9
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

79929:MTBMA RS06970
gene id: 79929:MTBMA_RS06970
uniprot id: D9PXR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

79929:MTBMA RS07165
gene id: 79929:MTBMA_RS07165
uniprot id: D9PXV0
names: Similarity
messages: Belongs to the HsdR family.

79929:MTBMA RS06285
gene id: 79929:MTBMA_RS06285
uniprot id: D9PXC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

79929:MTBMA RS02370
gene id: 79929:MTBMA_RS02370
uniprot id: D9PV29
names: Similarity
messages: Belongs to the class-I fumarase family.

79929:MTBMA RS07040
gene id: 79929:MTBMA_RS07040
uniprot id: D9PXS6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

79929:MTBMA RS07365
gene id: 79929:MTBMA_RS07365
uniprot id: D9PXZ1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

79929:MTBMA RS02475
gene id: 79929:MTBMA_RS02475
uniprot id: D9PV50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

79929:MTBMA RS00715
gene id: 79929:MTBMA_RS00715
uniprot id: Q50785
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg-100 inactivates the nitrogenase reductase and regulates nitrogenase activity.

79929:MTBMA RS06865
gene id: 79929:MTBMA_RS06865
uniprot id: D9PXP4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

79929:MTBMA RS07440
gene id: 79929:MTBMA_RS07440
uniprot id: P32440
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activity requires salt; 100 mM sodium or potassium salts of chloride, phosphate or sulfate are equally effective. Inactivated by O(2).
messages: Belongs to the HMD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.
messages: Homotetramer.

79929:MTBMA RS02285
gene id: 79929:MTBMA_RS02285
uniprot id: D9PV12
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

79929:MTBMA RS00205
gene id: 79929:MTBMA_RS00205
uniprot id: D9PYV6
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS06210
gene id: 79929:MTBMA_RS06210
uniprot id: D9PXB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

79929:MTBMA RS03570
gene id: 79929:MTBMA_RS03570
uniprot id: D9PVS3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

79929:MTBMA RS01965
gene id: 79929:MTBMA_RS01965
uniprot id: D9PUV1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

79929:MTBMA RS07470
gene id: 79929:MTBMA_RS07470
uniprot id: D9PY13
names: Similarity
messages: Belongs to the UPF0254 family.

79929:MTBMA RS00160
gene id: 79929:MTBMA_RS00160
uniprot id: D9PYU7
names: Similarity
messages: Belongs to the GARS family.

79929:MTBMA RS03565
gene id: 79929:MTBMA_RS03565
uniprot id: D9PVS2
names: Subcellular Location Annotation
messages: Cell membrane

79929:MTBMA RS01675
gene id: 79929:MTBMA_RS01675
uniprot id: D9PUP3
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

79929:MTBMA RS02530
gene id: 79929:MTBMA_RS02530
uniprot id: D9PV61
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

79929:MTBMA RS02595
gene id: 79929:MTBMA_RS02595
uniprot id: D9PV73
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

79929:MTBMA RS05685
gene id: 79929:MTBMA_RS05685
uniprot id: D9PX11
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

79929:MTBMA RS06975
gene id: 79929:MTBMA_RS06975
uniprot id: D9PXR8
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

79929:MTBMA RS04730
gene id: 79929:MTBMA_RS04730
uniprot id: D9PWG3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

79929:MTBMA RS07565
gene id: 79929:MTBMA_RS07565
uniprot id: P11564
names: Developmental Stage
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.
messages: There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contains mostly MCR I.

79929:MTBMA RS08615
gene id: 79929:MTBMA_RS08615
uniprot id: D9PYN4
names: Similarity
messages: Belongs to the UPF0127 family.

79929:MTBMA RS05985
gene id: 79929:MTBMA_RS05985
uniprot id: D9PX68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

79929:MTBMA RS03365
gene id: 79929:MTBMA_RS03365
uniprot id: D9PVN1
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

79929:MTBMA RS07530
gene id: 79929:MTBMA_RS07530
uniprot id: Q59584
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: Part of the probable mtrEDCBAFGH operon.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

79929:MTBMA RS06075
gene id: 79929:MTBMA_RS06075
uniprot id: D9PX86
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

79929:MTBMA RS07015
gene id: 79929:MTBMA_RS07015
uniprot id: D9PXS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

79929:MTBMA RS01180
gene id: 79929:MTBMA_RS01180
uniprot id: P26925
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: It is uncertain whether Met-1, Met-7 or Met-11 is the initiator.

79929:MTBMA RS07865
gene id: 79929:MTBMA_RS07865
uniprot id: D9PY93
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS06250
gene id: 79929:MTBMA_RS06250
uniprot id: D9PXC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0104 family.
messages: Membrane

79929:MTBMA RS00325
gene id: 79929:MTBMA_RS00325
uniprot id: D9PTX7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

79929:MTBMA RS01585
gene id: 79929:MTBMA_RS01585
uniprot id: D9PUM9
names: Similarity
messages: Belongs to the glutaredoxin family.

79929:MTBMA RS00295
gene id: 79929:MTBMA_RS00295
uniprot id: D9PTX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

79929:MTBMA RS05870
gene id: 79929:MTBMA_RS05870
uniprot id: P42035
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutaredoxin family.
messages: Cytoplasm
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. May be a component of a ribonucleotide-reducing system distinct from the previously described systems utilizing thioredoxin or glutaredoxin.

79929:MTBMA RS01035
gene id: 79929:MTBMA_RS01035
uniprot id: D9PUC1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

79929:MTBMA RS05325
gene id: 79929:MTBMA_RS05325
uniprot id: P80909
names: Cofactor
names: Subunit
messages: Binds 2 [4Fe-4S] clusters.
messages: Heterotrimer of the VorA, VorB and VorC subunits.

79929:MTBMA RS08365
gene id: 79929:MTBMA_RS08365
uniprot id: D9PYI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

79929:MTBMA RS06920
gene id: 79929:MTBMA_RS06920
uniprot id: P80905
names: Subunit
messages: Heterotetramer of the KorA, KorB, KorC and KorD subunits.

79929:MTBMA RS05195
gene id: 79929:MTBMA_RS05195
uniprot id: D9PWR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

79929:MTBMA RS04000
gene id: 79929:MTBMA_RS04000
uniprot id: D9PW10
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

79929:MTBMA RS02520
gene id: 79929:MTBMA_RS02520
uniprot id: D9PV59
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

79929:MTBMA RS06790
gene id: 79929:MTBMA_RS06790
uniprot id: D9PXM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

79929:MTBMA RS07315
gene id: 79929:MTBMA_RS07315
uniprot id: D9PXY1
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

79929:MTBMA RS04865
gene id: 79929:MTBMA_RS04865
uniprot id: D9PWJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

79929:MTBMA RS08665
gene id: 79929:MTBMA_RS08665
uniprot id: D9PYP4
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

79929:MTBMA RS05450
gene id: 79929:MTBMA_RS05450
uniprot id: D9PWW4
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

79929:MTBMA RS03345
gene id: 79929:MTBMA_RS03345
uniprot id: D9PVM7
names: Similarity
messages: Belongs to the MtxX family.

79929:MTBMA RS02545
gene id: 79929:MTBMA_RS02545
uniprot id: D9PV64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

79929:MTBMA RS07105
gene id: 79929:MTBMA_RS07105
uniprot id: D9PXT6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

79929:MTBMA RS01700
gene id: 79929:MTBMA_RS01700
uniprot id: D9PUP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

79929:MTBMA RS01560
gene id: 79929:MTBMA_RS01560
uniprot id: P80902
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

79929:MTBMA RS07045
gene id: 79929:MTBMA_RS07045
uniprot id: D9PXS7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

79929:MTBMA RS04545
gene id: 79929:MTBMA_RS04545
uniprot id: D9PWC5
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

79929:MTBMA RS05445
gene id: 79929:MTBMA_RS05445
uniprot id: D9PWW3
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

79929:MTBMA RS07405
gene id: 79929:MTBMA_RS07405
uniprot id: P60239
names: Function
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Part of a complex that provides reducing equivalents for heterodisulfide reductase.
messages: The F420-non-reducing hydrogenase is composed of three subunits; MvhA, MvhD and MvhG. It forms a complex with the heterodisulfide reductase (hdr).

79929:MTBMA RS08285
gene id: 79929:MTBMA_RS08285
uniprot id: D9PYG7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

79929:MTBMA RS05040
gene id: 79929:MTBMA_RS05040
uniprot id: D9PWM5
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

79929:MTBMA RS02600
gene id: 79929:MTBMA_RS02600
uniprot id: D9PV74
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

79929:MTBMA RS08655
gene id: 79929:MTBMA_RS08655
uniprot id: D9PYP2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

79929:MTBMA RS04645
gene id: 79929:MTBMA_RS04645
uniprot id: D9PWE6
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS00315
gene id: 79929:MTBMA_RS00315
uniprot id: D9PTX5
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Homodimer.

79929:MTBMA RS08330
gene id: 79929:MTBMA_RS08330
uniprot id: D9PYH6
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

79929:MTBMA RS04845
gene id: 79929:MTBMA_RS04845
uniprot id: D9PWI6
names: Similarity
messages: Belongs to the UPF0179 family.

79929:MTBMA RS00740
gene id: 79929:MTBMA_RS00740
uniprot id: P95297
names: Function
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).

79929:MTBMA RS07810
gene id: 79929:MTBMA_RS07810
uniprot id: D9PY82
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS06150
gene id: 79929:MTBMA_RS06150
uniprot id: D9PXA1
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

79929:MTBMA RS08050
gene id: 79929:MTBMA_RS08050
uniprot id: D9PYC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0104 family.
messages: Membrane

79929:MTBMA RS00630
gene id: 79929:MTBMA_RS00630
uniprot id: D9PU40
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS07060
gene id: 79929:MTBMA_RS07060
uniprot id: D9PXT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

79929:MTBMA RS00665
gene id: 79929:MTBMA_RS00665
uniprot id: Q50746
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.

79929:MTBMA RS04125
gene id: 79929:MTBMA_RS04125
uniprot id: D9PW36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

79929:MTBMA RS08000
gene id: 79929:MTBMA_RS08000
uniprot id: D9PYB9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

79929:MTBMA RS06870
gene id: 79929:MTBMA_RS06870
uniprot id: D9PXP5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS01530
gene id: 79929:MTBMA_RS01530
uniprot id: D9PUL8
names: Similarity
messages: Belongs to the class-I fumarase family.

79929:MTBMA RS07055
gene id: 79929:MTBMA_RS07055
uniprot id: D9PXS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

79929:MTBMA RS04245
gene id: 79929:MTBMA_RS04245
uniprot id: D9PW63
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS04235
gene id: 79929:MTBMA_RS04235
uniprot id: D9PW61
names: Subcellular Location Annotation
messages: Membrane

79929:MTBMA RS01200
gene id: 79929:MTBMA_RS01200
uniprot id: D9PUF4
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

79929:MTBMA RS00065
gene id: 79929:MTBMA_RS00065
uniprot id: D9PYT0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

79929:MTBMA RS00155
gene id: 79929:MTBMA_RS00155
uniprot id: D9PYU6
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

79929:MTBMA RS06735
gene id: 79929:MTBMA_RS06735
uniprot id: D9PXL8
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

79929:MTBMA RS05530
gene id: 79929:MTBMA_RS05530
uniprot id: D9PWY0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

79929:MTBMA RS07275
gene id: 79929:MTBMA_RS07275
uniprot id: D9PXX3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

79929:MTBMA RS07035
gene id: 79929:MTBMA_RS07035
uniprot id: D9PXS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

79929:MTBMA RS08510
gene id: 79929:MTBMA_RS08510
uniprot id: D9PYL2
names: Function
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

79929:MTBMA RS00970
gene id: 79929:MTBMA_RS00970
uniprot id: D9PUA8
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

79929:MTBMA RS04905
gene id: 79929:MTBMA_RS04905
uniprot id: D9PWJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

79929:MTBMA RS06535
gene id: 79929:MTBMA_RS06535
uniprot id: D9PXH8
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.