7955:cox4i1
gene id: 7955:cox4i1
uniprot id: Q6TNV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

7955:or102-2
gene id: 7955:or102-2
uniprot id: Q2PRB6
uniprot id: Q9I8Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:atp1b3a
gene id: 7955:atp1b3a
uniprot id: A0A8M9PS98
uniprot id: A0A8M9QJR8
uniprot id: Q8QHI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

7955:rftn1a
gene id: 7955:rftn1a
uniprot id: E9QG04
uniprot id: F6NSR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

7955:gig2j
gene id: 7955:gig2j
uniprot id: B3DIL1
names: Similarity
messages: Belongs to the ARTD/PARP family.

7955:gli1
gene id: 7955:gli1
uniprot id: F1QAC4
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

7955:tmem59l
gene id: 7955:tmem59l
uniprot id: A8WG81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:tspan33a
gene id: 7955:tspan33a
uniprot id: Q5RH71
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Homodimer; disulfide-linked.
messages: Membrane

7955:vps13a
gene id: 7955:vps13a
uniprot id: A0A8M1NGM5
uniprot id: A0A8M2BET3
uniprot id: A0A8M3AVK3
uniprot id: A0A8M3B2B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS13 family.
messages: Lipid droplet

7955:ap1s3b
gene id: 7955:ap1s3b
uniprot id: Q66IE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

7955:mogat3a
gene id: 7955:mogat3a
uniprot id: A0A8M9P5P1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:stard8
gene id: 7955:stard8
uniprot id: A0A8M2BJ68
uniprot id: A0A8M2BJQ2
uniprot id: A0A8M9QE11
uniprot id: B0S5B4
names: Subcellular Location Annotation
messages: Cytoplasm

7955:nme2b.2
gene id: 7955:nme2b.2
uniprot id: Q7SXL4
names: Similarity
messages: Belongs to the NDK family.

7955:htra1a
gene id: 7955:htra1a
uniprot id: B2GT42
uniprot id: Q6GMI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1C family.
messages: Forms homotrimers. In the presence of substrate, may form higher-order multimers in a PDZ-independent manner.
messages: Secreted
messages: Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets (By similarity).
messages: cytosol

7955:slc17a9b
gene id: 7955:slc17a9b
uniprot id: Q6DHM5
names: Subcellular Location Annotation
messages: Membrane

7955:foxo3b
gene id: 7955:foxo3b
uniprot id: Q9W7F8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7955:prpf39
gene id: 7955:prpf39
uniprot id: Q1JPZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP39 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

7955:mast1b
gene id: 7955:mast1b
uniprot id: A0A8M3AXQ6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

7955:prkcq
gene id: 7955:prkcq
uniprot id: A0A8M3B909
uniprot id: F1R506
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

7955:mycn
gene id: 7955:mycn
uniprot id: Q5GFD4
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.
messages: Nucleus

7955:si:ch211-212c13.10
gene id: 7955:si:ch211-212c13.10
uniprot id: A0A8M1QHK3
uniprot id: A0A8M3AHH2
uniprot id: A0A8M3B150
uniprot id: A0A8M9PCC9
uniprot id: A0A8M9PIL6
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.

7955:st6gal2a
gene id: 7955:st6gal2a
uniprot id: F1Q8R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

7955:plppr3a
gene id: 7955:plppr3a
uniprot id: B0V0Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

7955:slc25a21
gene id: 7955:slc25a21
uniprot id: Q08C83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7955:mdm2
gene id: 7955:mdm2
uniprot id: A0A8M2BC69
uniprot id: Q561Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

7955:mrpl44
gene id: 7955:mrpl44
uniprot id: F1RB48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.
messages: Mitochondrion

7955:slc20a2
gene id: 7955:slc20a2
uniprot id: A0A8M2BEK1
uniprot id: F1Q836
uniprot id: Q08CK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter.

7955:naa35
gene id: 7955:naa35
uniprot id: Q7T322
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Regulates cell proliferation during embryonic development. May be involved in acetylating the N-terminus of mtor.
messages: Belongs to the MAK10 family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of naa35, naa38 and naa30.
messages: Cytoplasm
messages: Expressed at high levels at 6 hpf. Expression levels remain high through 18 hpf and 28 hpf in many developing tissues suCh as vascular structures or epidermis. By 48 hpf, expression is restricted to the head. At 5 dpf, expression is restricted to epidermis.
messages: PubMed:16484612 decribes a naa35/zEgap-containing complex as evolutionary conserved NatC complex; however, the zMak3 protein investigated in this context corresponds to mammalian NAA50 and not NAA30 and its interaction with NAA35 is ambiguous.

7955:parla
gene id: 7955:parla
uniprot id: A0A8M3AN88
uniprot id: A0A8M3AN93
uniprot id: A0A8M9PWK1
uniprot id: B2GQL1
uniprot id: Q58EK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of opa1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals.

7955:pter
gene id: 7955:pter
uniprot id: F1RBR6
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
messages: Binds 2 divalent metal cations per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:xirp1
gene id: 7955:xirp1
uniprot id: A0A8M9PW88
uniprot id: A0A8M9Q8B1
uniprot id: Q5PZ43
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Xin family.
messages: Cell junction
messages: Interacts with F-actin, FLNC and VASP.
messages: Protects actin filaments from depolymerization.
messages: Xin repeats bind F-actin.

7955:surf4
gene id: 7955:surf4
uniprot id: Q7SZQ7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion. Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

7955:elp4
gene id: 7955:elp4
uniprot id: A0A0R4IEA9
uniprot id: Q566Y1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELP4 family.
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
messages: Component of the elongator complex.
messages: Cytoplasm
messages: Nucleus
messages: The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification.

7955:LOC557729
gene id: 7955:LOC557729
uniprot id: A0A8N7UV06
names: Caution
names: Similarity
messages: Belongs to the HINT family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:adck3
gene id: 7955:adck3
uniprot id: Q5RGU1
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adopts an atypical protein kinase-like fold: while it adopts a core fold similar to that of well-characterized protein kinase-like domains. The KxGQ motif completely occludes the typical substrate binding pocket. Nucleotide-binding opens the substrate binding pocket and flips the active site from inside the hydrophobic core into a catalytically competent, solvent-exposed posture.
messages: Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates. Shows an unusual selectivity for binding ADP over ATP.
messages: Autoinhibited by the N-terminal domain, containing the KxGQ motif, that completely occludes the typical substrate binding pocket. Nucleotide-binding relieves inhibition.
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Homodimer; homodimerizes via its transmembrane region. Interacts with the multi-subunit COQ enzyme complex.
messages: Membrane
messages: Mitochondrion

7955:LOC108190747
gene id: 7955:LOC108190747
uniprot id: A8KBJ5
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:fzd3b
gene id: 7955:fzd3b
uniprot id: A0JBX4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:si:ch211-186j3.6
gene id: 7955:si:ch211-186j3.6
uniprot id: F1QK15
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:igf2bp3
gene id: 7955:igf2bp3
uniprot id: A0A0R4IYT0
uniprot id: A0A8M9P1P8
uniprot id: B2GT58
uniprot id: Q9PW80
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: All KH domains contribute binding to target mRNA. Domains KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 also contribute. They are also required for RNA-dependent homo- and heterooligomerization. The integrity of KH domains seems not to be required for localization to stress granules.
messages: Belongs to the RRM IMP/VICKZ family.
messages: Cytoplasm
messages: Expressed in oocytes from stages I to III. Expressed in 8-cell embryo. Expressed in brain, eye, branchial arches and neural tube at 24 hours post-fertilization (hpf). Detected predominantly in the CNS, putative neural crest, the sensorial layer of the epidermal ectoderm and their derivatives until the tailbud stage.
messages: Homodimer and multimer.
messages: Nucleus
messages: P-body
messages: RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (By similarity). Involved in neuronal crest migration (PubMed:14522877).
messages: Stress granule

7955:hoxb4a
gene id: 7955:hoxb4a
uniprot id: B3DHP6
uniprot id: P22574
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Belongs to the Antp homeobox family. Deformed subfamily.
messages: First expressed at the 1-somite stage with an anterior expression limit in rhombomere 7 (r7) of the developing hindbrain. By the 15-somite stage, the anterior expression limit is at the r6/r7 boundary and this is maintained until at least 30 hours of development. At the 10-somite stage, weakly expressed in the paraxial mesoderm with an anterior expression limit at somite 1.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

7955:cstf1
gene id: 7955:cstf1
uniprot id: F1QFK9
names: Subcellular Location Annotation
messages: Nucleus

7955:LOC110439709
gene id: 7955:LOC110439709
uniprot id: A0A8M9Q2J8
names: Similarity
messages: Belongs to the HARBI1 family.

7955:kpna6
gene id: 7955:kpna6
uniprot id: E7F7U9
names: Similarity
messages: Belongs to the importin alpha family.

7955:slc25a47a
gene id: 7955:slc25a47a
uniprot id: A0A8M6YU82
uniprot id: A0A8M9PBY2
uniprot id: A0A8M9PHJ4
uniprot id: Q1ECW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

7955:LOC100331987
gene id: 7955:LOC100331987
uniprot id: A0A2R8Q401
uniprot id: A0A8M1RHI1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:cecr1b
gene id: 7955:cecr1b
uniprot id: F6NKG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.
messages: Secreted

7955:LOC101882566
gene id: 7955:LOC101882566
uniprot id: A0A8M9QLH0
names: Subcellular Location Annotation
messages: Membrane

7955:med13a
gene id: 7955:med13a
uniprot id: E7FCQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

7955:si:ch1073-416d2.3
gene id: 7955:si:ch1073-416d2.3
uniprot id: A0A8M3AK66
names: Similarity
messages: Belongs to the serpin family.

7955:insrb
gene id: 7955:insrb
uniprot id: Q1LVG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

7955:gfra3
gene id: 7955:gfra3
uniprot id: E7F4G1
names: Similarity
messages: Belongs to the GDNFR family.

7955:ube2h
gene id: 7955:ube2h
uniprot id: Q7ZUF3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7955:caprin1b
gene id: 7955:caprin1b
uniprot id: A0A8M9P113
uniprot id: A0A8M9PM15
uniprot id: Q802U4
names: Similarity
messages: Belongs to the caprin family.

7955:cyp3c1
gene id: 7955:cyp3c1
uniprot id: Q7ZTW6
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:slc38a2
gene id: 7955:slc38a2
uniprot id: Q5SPB1
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Cell membrane
messages: Inhibited by N-methyl-D-glucamine. Inhibited by choline. Allosteric regulation of sodium ions binding by pH.
messages: Symporter that cotransports neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane. The trasnport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1.
messages: The extracellular C-terminal domain controls the voltage dependence for amino acid transports activity.

7955:LOC103911930
gene id: 7955:LOC103911930
uniprot id: A0A8M9Q8Z4
names: Function
names: Similarity
messages: Belongs to the peptidase M54 family.
messages: Probable zinc metalloprotease.

7955:mtmr1a
gene id: 7955:mtmr1a
uniprot id: A0A8M2BJN3
uniprot id: A0A8M2BJP1
uniprot id: A0A8M3B116
uniprot id: A0A8M3B3Y3
uniprot id: Q501S9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

7955:mon1a
gene id: 7955:mon1a
uniprot id: F1QDK1
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

7955:wnt7ba
gene id: 7955:wnt7ba
uniprot id: F1Q5B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

7955:gnaq
gene id: 7955:gnaq
uniprot id: B8JLJ7
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

7955:tfr2
gene id: 7955:tfr2
uniprot id: Q5MPX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

7955:pnocb
gene id: 7955:pnocb
uniprot id: Q5RIC2
names: Similarity
messages: Belongs to the opioid neuropeptide precursor family.

7955:tsc22d2
gene id: 7955:tsc22d2
uniprot id: A0A2R8RWC4
uniprot id: Q6TEL2
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

7955:gstt1b
gene id: 7955:gstt1b
uniprot id: Q6PH41
names: Similarity
messages: Belongs to the GST superfamily. Theta family.

7955:gucy1a2
gene id: 7955:gucy1a2
uniprot id: A0A8M3AT28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

7955:cyp2aa11
gene id: 7955:cyp2aa11
uniprot id: A0A8M6Z3U8
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:si:ch211-119e14.2
gene id: 7955:si:ch211-119e14.2
uniprot id: B2KJ26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

7955:tead3b
gene id: 7955:tead3b
uniprot id: A0A8M2BDI0
uniprot id: A0A8M2BDI4
uniprot id: A0A8M2BDJ0
uniprot id: A0A8M2BDL1
uniprot id: A0A8M2BDM4
uniprot id: A0A8M2BDQ4
uniprot id: A7MBZ7
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.

7955:slc6a4a
gene id: 7955:slc6a4a
uniprot id: A0A8M3APU9
uniprot id: Q1WGB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:psmb1
gene id: 7955:psmb1
uniprot id: Q6DRF3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Morphant larvae have a strikingly smaller head compared with controls, a mild degree of edema surrounding the eyes, and a significant decrease in head/body length ratio. The eye size is significantly decreased in the morphants compared with controls.
messages: Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation.
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits psmb5, psmb6 and psmb7.

7955:hs3st3l
gene id: 7955:hs3st3l
uniprot id: A0MGZ2
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

7955:gapdhs
gene id: 7955:gapdhs
uniprot id: Q5MJ86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate.
messages: Homotetramer.

7955:zgc:165502
gene id: 7955:zgc:165502
uniprot id: A5PLB2
names: Similarity
messages: Belongs to the folate receptor family.

7955:arpc5la
gene id: 7955:arpc5la
uniprot id: Q6P0D3
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

7955:pdha1a
gene id: 7955:pdha1a
uniprot id: A0A0R4IT09
uniprot id: Q6P948
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

7955:ptpra
gene id: 7955:ptpra
uniprot id: A0A8M9P361
uniprot id: F1QE38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
messages: Cell membrane
messages: Membrane

7955:ppm1nb
gene id: 7955:ppm1nb
uniprot id: A7MBY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

7955:akt2
gene id: 7955:akt2
uniprot id: Q8UUX0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

7955:LOC100537098
gene id: 7955:LOC100537098
uniprot id: A0A8M6YTJ6
uniprot id: A0A8M9PFL4
names: Similarity
messages: Belongs to the ARTD/PARP family.

7955:LOC100332428
gene id: 7955:LOC100332428
uniprot id: A0A8M6Z8E6
names: Similarity
messages: Belongs to the ARTD/PARP family.

7955:LOC100000884
gene id: 7955:LOC100000884
uniprot id: A0A8M6Z2G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

7955:icn2
gene id: 7955:icn2
uniprot id: A3FKT8
names: Similarity
messages: Belongs to the S-100 family.

7955:he1a
gene id: 7955:he1a
uniprot id: Q1LW00
uniprot id: Q4G0A2
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:cklf
gene id: 7955:cklf
uniprot id: A0A8M1RDN2
names: Subcellular Location Annotation
messages: Membrane

7955:clic3
gene id: 7955:clic3
uniprot id: Q6P5J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Membrane

7955:cyb5a
gene id: 7955:cyb5a
uniprot id: A8WGS0
uniprot id: Q7T341
names: Similarity
messages: Belongs to the cytochrome b5 family.

7955:farsa
gene id: 7955:farsa
uniprot id: Q1JPX3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Cytoplasm
messages: Heterotetramer; dimer of two heterodimers formed by alpha and beta subunits.

7955:dnajc18
gene id: 7955:dnajc18
uniprot id: A8WG70
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:si:ch211-149b19.3
gene id: 7955:si:ch211-149b19.3
uniprot id: A0A8M3B6G2
uniprot id: A0A8M9P5N7
uniprot id: E7FAZ1
names: Similarity
messages: Belongs to the PP2C family.

7955:tmem178b
gene id: 7955:tmem178b
uniprot id: Q1L8F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM178 family.
messages: Membrane

7955:drd4b
gene id: 7955:drd4b
uniprot id: Q5DJ14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:galnt14
gene id: 7955:galnt14
uniprot id: A0A8M1N9Y0
uniprot id: A0A8M6Z2P3
uniprot id: A0A8M9PHF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

7955:prkg1l
gene id: 7955:prkg1l
uniprot id: A0A8M6Z2D7
uniprot id: A0A8M9PRK8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

7955:pcolceb
gene id: 7955:pcolceb
uniprot id: A0A8M3AUI0
uniprot id: B3DJG2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:gtf2a1l
gene id: 7955:gtf2a1l
uniprot id: A0A8M6Z2C8
uniprot id: Q08BV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

7955:fgf23
gene id: 7955:fgf23
uniprot id: Q5MK87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Secreted

7955:zgc:66475
gene id: 7955:zgc:66475
uniprot id: A0A0R4IS22
uniprot id: A0A8M2BFQ9
uniprot id: A0A8M9QL92
uniprot id: Q7SYI9
names: Similarity
messages: Belongs to the DNA photolyase class-2 family.

7955:fdxr
gene id: 7955:fdxr
uniprot id: E7FB58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferredoxin--NADP reductase type 1 family.
messages: Mitochondrion
messages: Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.

7955:hsd17b7
gene id: 7955:hsd17b7
uniprot id: Q08BC5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.

7955:slain1b
gene id: 7955:slain1b
uniprot id: B1WB95
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

7955:gcga
gene id: 7955:gcga
uniprot id: A0A0R4IS85
uniprot id: F1RD10
names: Similarity
messages: Belongs to the glucagon family.

7955:epc1a
gene id: 7955:epc1a
uniprot id: A0A0R4ICZ3
uniprot id: A0A8M9PXA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

7955:wnt4b
gene id: 7955:wnt4b
uniprot id: Q9IAU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

7955:zgc:112148
gene id: 7955:zgc:112148
uniprot id: Q561U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

7955:prdm1c
gene id: 7955:prdm1c
uniprot id: A0A8M6Z3C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

7955:LOC108179126
gene id: 7955:LOC108179126
uniprot id: A0A8M6YXT6
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:lsm14ab
gene id: 7955:lsm14ab
uniprot id: A0A0R4IVM1
uniprot id: A0A8M2B5X3
uniprot id: Q6P0B2
names: Similarity
messages: Belongs to the LSM14 family.

7955:kcnj12b
gene id: 7955:kcnj12b
uniprot id: E7F807
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Cell membrane
messages: Membrane

7955:si:ch211-284k5.2
gene id: 7955:si:ch211-284k5.2
uniprot id: A0A0R4IW21
uniprot id: A0A2R8QD25
names: Similarity
messages: Belongs to the CFAP97 family.

7955:tspan3a
gene id: 7955:tspan3a
uniprot id: Q4V915
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7955:atp6v1ba
gene id: 7955:atp6v1ba
uniprot id: Q8QHA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

7955:tdp1
gene id: 7955:tdp1
uniprot id: F8W5U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: Nucleus

7955:h2afx
gene id: 7955:h2afx
uniprot id: Q7ZUY3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Monoubiquitination of Lys-120 (H2AXK119ub) by ring1 and rnf2/ring2 complex gives a specific tag for epigenetic transcriptional repression. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase ube2n and the E3 ligases rnf8 and rnf168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by rnf168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; rnf8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events (By similarity).
messages: Nucleus
messages: Phosphorylated. Phosphorylation of Ser-139 (H2AX139ph) occurs in response to DNA double strand breaks (DSBs) generated by exogenous genotoxic agents, by stalled replication forks and by meiotic recombination events. Phosphorylation is dependent on the DNA damage checkpoint kinases ATR and ATM, spreads on either side of a detected DSB site and may mark the surrounding chromatin for recruitment of proteins required for DNA damage signaling and repair. Widespread phosphorylation may also serve to amplify the damage signal or aid repair of persistent lesions. Dephosphorylation of Ser-139 is required for DNA DSB repair. Phosphorylation at Tyr-142 (H2AXY142ph) by baz1b/wstf determines the relative recruitment of either DNA repair or pro-apoptotic factors. Phosphorylation at Tyr-142 (H2AXY142ph) favors the recruitment of pro-apoptosis factors. In contrast, dephosphorylation of Tyr-142 by EYA proteins (eya1, eya2, eya3 or eya4) favors the recruitment of MDC1-containing DNA repair complexes to the tail of phosphorylated Ser-139 (H2AX139ph).
messages: The [ST]-Q motif constitutes a recognition sequence for kinases from the PI3/PI4-kinase family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with numerous proteins required for DNA damage signaling and repair when phosphorylated on Ser-139 (By similarity).
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation (By similarity).

7955:srp68
gene id: 7955:srp68
uniprot id: A7YYE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
messages: Cytoplasm
messages: nucleolus

7955:gprc5bb
gene id: 7955:gprc5bb
uniprot id: A0A8M2B722
uniprot id: B8A4H2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:utp23
gene id: 7955:utp23
uniprot id: A0A0R4IA74
uniprot id: Q568M1
names: Subcellular Location Annotation
messages: nucleolus

7955:cyp27a7
gene id: 7955:cyp27a7
uniprot id: F1Q7H1
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:etv1
gene id: 7955:etv1
uniprot id: A0A8M2B3T9
uniprot id: B3DIF9
uniprot id: Q4VCI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

7955:rpl17
gene id: 7955:rpl17
uniprot id: Q7T1K0
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

7955:LOC100002591
gene id: 7955:LOC100002591
uniprot id: A0A8M6YU70
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:or115-9
gene id: 7955:or115-9
uniprot id: Q2PRI1
names: Subcellular Location Annotation
messages: Membrane

7955:lrrc14b
gene id: 7955:lrrc14b
uniprot id: Q1L8H0
names: Similarity
messages: Belongs to the PRAME family. LRRC14 subfamily.

7955:ptpn4a
gene id: 7955:ptpn4a
uniprot id: Q8JFS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

7955:cln8
gene id: 7955:cln8
uniprot id: F1QYC0
names: Subcellular Location Annotation
messages: Membrane

7955:fgfbp1b
gene id: 7955:fgfbp1b
uniprot id: A0A8M9Q0I5
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

7955:v2rh7
gene id: 7955:v2rh7
uniprot id: A0A8M9PQE4
uniprot id: A3KQI0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:kif1ab
gene id: 7955:kif1ab
uniprot id: A0A8M2BIG3
uniprot id: A0A8M3APQ1
uniprot id: A0A8M3AQ79
uniprot id: A0A8M3B098
uniprot id: A0A8M3B7Q1
uniprot id: A0A8M9P8Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: axon

7955:ntrk3b
gene id: 7955:ntrk3b
uniprot id: A0A0H2UKW5
uniprot id: A0A8M1RHB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

7955:mmp20a
gene id: 7955:mmp20a
uniprot id: A0A8M6YV12
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

7955:si:ch73-211l2.1
gene id: 7955:si:ch73-211l2.1
uniprot id: B8JM89
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

7955:si:ch211-199o1.2
gene id: 7955:si:ch211-199o1.2
uniprot id: A0A8M1NE33
names: Similarity
messages: Belongs to the heat shock protein 70 family.

7955:nfya
gene id: 7955:nfya
uniprot id: A0A8M2BKP2
uniprot id: A0A8M3AXW0
uniprot id: A0A8M3B723
uniprot id: A3KNH7
uniprot id: E9QGB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

7955:osbpl6
gene id: 7955:osbpl6
uniprot id: A0A8M2BJS4
uniprot id: A0A8M3AVN8
uniprot id: A0A8M3B2E3
uniprot id: A0A8M6Z041
uniprot id: A0A8M6Z7Y1
names: Similarity
messages: Belongs to the OSBP family.

7955:kpnb3
gene id: 7955:kpnb3
uniprot id: A0A8N7UZ95
uniprot id: B8JHR9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7955:cacng8b
gene id: 7955:cacng8b
uniprot id: A0A8M3AIY9
uniprot id: E9QCW1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:exoc3l2b
gene id: 7955:exoc3l2b
uniprot id: A0A8M3B147
uniprot id: E7EY52
names: Similarity
messages: Belongs to the SEC6 family.

7955:donson
gene id: 7955:donson
uniprot id: A0A8M9PJE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DONSON family.
messages: Nucleus

7955:elavl4
gene id: 7955:elavl4
uniprot id: A0A0R4IEW8
uniprot id: A0A8M2BEA7
uniprot id: A0A8M6Z808
uniprot id: A0A8M9Q398
uniprot id: A0A8M9Q9I0
uniprot id: A0A8M9QIF9
uniprot id: F1QGR7
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RRM elav family.
messages: Cytoplasm
messages: Expressed in motor neurons.
messages: Interacts with smn1.
messages: Perikaryon
messages: RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs (By similarity). Plays a role in the regulation of mRNA stability, alternative splicing and translation (By similarity). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (3'UTR) of target mRNAs (By similarity). Mainly plays a role in neuron-specific RNA processing (By similarity). Required for the maturation of motor neuron axonal branches and dendrites (PubMed:29061699).
messages: Reduced overall movement, decreased initiation of swim and turn movements and decreased mean body curvature change per swim half-cycle and mean number of swim half-cycles per swim (PubMed:29061699). At 2 and 4 dpf, decreased axonal branches and at 4 dpf, decreased dendrites in motor neurons (PubMed:29061699). Defects on motor neuron extensions persist at 26 dph (PubMed:29061699). Decreased GAP43 mRNA levels (PubMed:29061699).
messages: axon
messages: dendrite
messages: growth cone

7955:cnot3a
gene id: 7955:cnot3a
uniprot id: A0A8M9P7W2
uniprot id: E9QGK5
uniprot id: F1Q4L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT2/3/5 family.
messages: Nucleus

7955:opn4b
gene id: 7955:opn4b
uniprot id: A0A8M3AY65
uniprot id: G8Z411
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:cct5
gene id: 7955:cct5
uniprot id: Q6NVI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

7955:si:dkey-42l23.5
gene id: 7955:si:dkey-42l23.5
uniprot id: A0A8M6YSE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

7955:chmp3
gene id: 7955:chmp3
uniprot id: Q6NY88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Endosome
messages: Late endosome membrane
messages: Membrane
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor (By similarity).
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially (By similarity).
messages: cytosol

7955:lyve1b
gene id: 7955:lyve1b
uniprot id: A0A2R8QLT6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:vdac1
gene id: 7955:vdac1
uniprot id: Q6NWC1
names: Similarity
messages: Belongs to the eukaryotic mitochondrial porin family.

7955:srp9
gene id: 7955:srp9
uniprot id: Q7ZW94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm

7955:si:ch73-238c9.1
gene id: 7955:si:ch73-238c9.1
uniprot id: A0A8M9QHW1
uniprot id: E7F2Z1
names: Similarity
messages: Belongs to the UPF0449 family.

7955:ppp3cb
gene id: 7955:ppp3cb
uniprot id: A0A8M3AZJ8
uniprot id: A0A8M3BEY4
uniprot id: A0A8M9QGE2
uniprot id: Q568R4
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

7955:slit3
gene id: 7955:slit3
uniprot id: A0A8M3ARY3
uniprot id: F1RCV3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:irgq1
gene id: 7955:irgq1
uniprot id: X1WE34
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

7955:si:dkey-199f5.8
gene id: 7955:si:dkey-199f5.8
uniprot id: E7FCM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

7955:LOC100334158
gene id: 7955:LOC100334158
uniprot id: A0A8M9PLL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cytoplasm

7955:cpne4b
gene id: 7955:cpne4b
uniprot id: E9QJ75
names: Similarity
messages: Belongs to the copine family.

7955:cep76
gene id: 7955:cep76
uniprot id: F1R7N3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP76 family.
messages: Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.
messages: centriole

7955:gja5a
gene id: 7955:gja5a
uniprot id: F1QL21
uniprot id: Q8AX88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

7955:wdr73
gene id: 7955:wdr73
uniprot id: Q567G2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR73 family.
messages: Cleavage furrow
messages: May play a role in the regulation of microtubule organization and dynamics.
messages: cytosol
messages: spindle
messages: spindle pole

7955:si:dkeyp-13a3.8
gene id: 7955:si:dkeyp-13a3.8
uniprot id: A0A0R4IS95
names: Similarity
messages: Belongs to the MAP7 family.

7955:pex19
gene id: 7955:pex19
uniprot id: Q561W9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-19 family.
messages: Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.
messages: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
messages: Peroxisome membrane

7955:twf1a
gene id: 7955:twf1a
uniprot id: Q6PEI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

7955:bmp2a
gene id: 7955:bmp2a
uniprot id: O13109
names: Similarity
messages: Belongs to the TGF-beta family.

7955:si:ch211-214j24.9
gene id: 7955:si:ch211-214j24.9
uniprot id: A0A286Y9N9
uniprot id: A0A8M3B8R1
uniprot id: A0A8M9PI70
uniprot id: A0A8M9PVI2
uniprot id: A0A8M9Q1F3
uniprot id: A0A8M9Q6P3
uniprot id: A0A8M9QC73
names: Similarity
messages: Belongs to the PICALM/SNAP91 family.

7955:LOC110440027
gene id: 7955:LOC110440027
uniprot id: A0A8M9QF23
names: Subcellular Location Annotation
messages: Membrane

7955:irx5b
gene id: 7955:irx5b
uniprot id: Q6R5L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

7955:adck5
gene id: 7955:adck5
uniprot id: A0A8M3ASF6
uniprot id: F1Q5S6
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

7955:cdc45
gene id: 7955:cdc45
uniprot id: Q7ZU79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

7955:scpep1
gene id: 7955:scpep1
uniprot id: Q7ZVE2
names: Similarity
messages: Belongs to the peptidase S10 family.

7955:aup1
gene id: 7955:aup1
uniprot id: A0A8M2BKB9
uniprot id: Q6PBN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AUP1 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Membrane
messages: Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (By similarity). Plays a role in lipid droplet formation (By similarity). Induces lipid droplet clustering (By similarity).

7955:ctnnbip1
gene id: 7955:ctnnbip1
uniprot id: Q9I903
names: Similarity
messages: Belongs to the CTNNBIP1 family.

7955:gsto2
gene id: 7955:gsto2
uniprot id: Q5U3M8
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

7955:nr1h5
gene id: 7955:nr1h5
uniprot id: A0A8M2BEQ0
uniprot id: B0S5T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

7955:atp13a3
gene id: 7955:atp13a3
uniprot id: A0A8M3AXS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

7955:ralgps1
gene id: 7955:ralgps1
uniprot id: B0UXH6
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Guanine nucleotide exchange factor. May be involved in cytoskeletal organization.
messages: The PH domain mediates binding to membranes.

7955:si:ch73-374l24.1
gene id: 7955:si:ch73-374l24.1
uniprot id: A0A8M3AR84
uniprot id: A0A8M3B1B9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.
messages: Cytoplasm
messages: Membrane

7955:ackr3b
gene id: 7955:ackr3b
uniprot id: A4IG54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:emp2
gene id: 7955:emp2
uniprot id: A0A8M9PUL4
uniprot id: Q68EL5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:sgip1b
gene id: 7955:sgip1b
uniprot id: A0A8M3AZW6
uniprot id: A0A8M6YVC9
uniprot id: A0A8M6Z197
names: Subcellular Location Annotation
messages: clathrin-coated pit

7955:LOC101882949
gene id: 7955:LOC101882949
uniprot id: A0A8M6YV11
uniprot id: A0A8M9PTI4
names: Similarity
messages: Belongs to the EVA1 family.

7955:vldlr
gene id: 7955:vldlr
uniprot id: A0A0R4IGN2
uniprot id: A0A8M2B1M8
uniprot id: A0A8M2B226
uniprot id: A0A8M9PTE7
uniprot id: E7FF13
uniprot id: E9QBA5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:bco2a
gene id: 7955:bco2a
uniprot id: F1QU45
names: Cofactor
names: Similarity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.

7955:si:dkey-106c17.3
gene id: 7955:si:dkey-106c17.3
uniprot id: F1QIE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

7955:pdk1
gene id: 7955:pdk1
uniprot id: E7F3U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

7955:asrgl1
gene id: 7955:asrgl1
uniprot id: B2GNT8
uniprot id: Q5BKW9
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Abnormal and deformed fish at 6 dpf.
messages: Belongs to the Ntn-hydrolase family.
messages: Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity.
messages: Cytoplasm
messages: Has both L-asparaginase and beta-aspartyl peptidase activity. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.
messages: Heterodimer of an alpha and beta chain produced by autocleavage.

7955:sfpq
gene id: 7955:sfpq
uniprot id: Q6NUU2
names: Subcellular Location Annotation
messages: Nucleus speckle

7955:adgre15
gene id: 7955:adgre15
uniprot id: A0A8M9PNX8
uniprot id: A0A8M9Q1L4
uniprot id: A0A8M9QH00
names: Subcellular Location Annotation
messages: Membrane

7955:zgc:92606
gene id: 7955:zgc:92606
uniprot id: Q6DH82
names: Similarity
messages: Belongs to the ATG8 family.

7955:dhrs11b
gene id: 7955:dhrs11b
uniprot id: F1R5X7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:ephx5
gene id: 7955:ephx5
uniprot id: A0A8M2BK97
uniprot id: A0A8M9QAE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

7955:ilk
gene id: 7955:ilk
uniprot id: Q6PHD6
names: Subcellular Location Annotation
messages: lamellipodium
messages: sarcomere

7955:bri3
gene id: 7955:bri3
uniprot id: E7FAC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRI3 family.
messages: Membrane
messages: perinuclear region

7955:nup188
gene id: 7955:nup188
uniprot id: E7EXJ6
names: Subcellular Location Annotation
messages: nuclear pore complex

7955:si:dkey-202l16.5
gene id: 7955:si:dkey-202l16.5
uniprot id: A0A8M3B8A3
uniprot id: E7FDU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

7955:nrarpb
gene id: 7955:nrarpb
uniprot id: Q7T3X9
names: Developmental Stage
names: Function
names: Similarity
messages: Belongs to the NRARP family.
messages: First detected at low levels in the blastula stage and begins to accumulate in the margin of the blastoderm. At the shield stage, when gastrulation starts, expression is higher on the dorsal site. As gastrulation proceeds, expressed at high levels in the anterior ectoderm. In the 1 day old embryo, at the early pharyngula stage, expression in the developing brain is very strong and expression extends in to the spinal cord.
messages: Regulates independently canonical Wnt and Notch signaling by modulating LEF1 and Notch protein turnover. Stabilizes LEF1, a pivotal transcription factor in the Wnt signaling cascade, by blocking its ubiquitination. Involved in angiogenesis; involved in intersegmental vessel patterning during development.

7955:fgfr4
gene id: 7955:fgfr4
uniprot id: Q90413
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Endosome
messages: Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by autophosphorylation on tyrosine residues (By similarity).
messages: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway (By similarity).
messages: Ubiquitinated. Subject to proteasomal degradation when not fully glycosylated (By similarity).

7955:figf
gene id: 7955:figf
uniprot id: A0A8M3AXQ4
uniprot id: Q208T6
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

7955:cep170ab
gene id: 7955:cep170ab
uniprot id: A0A8M1RF07
uniprot id: A0A8M3AT34
names: Similarity
messages: Belongs to the CEP170 family.

7955:ago2
gene id: 7955:ago2
uniprot id: A0A8M3AKD0
uniprot id: K4I874
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argonaute family. Ago subfamily.
messages: Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of dicer1, ago2 and tarbp2. Note that the trimeric RLC/miRLC is also referred to as RISC.
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by ago2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur.
messages: The Piwi domain may perform RNA cleavage by a mechanism similar to that of RNase H. However, while RNase H utilizes a triad of Asp-Asp-Glu (DDE) for metal ion coordination, this protein appears to utilize a triad of Asp-Asp-His (DDH).

7955:abcc8b
gene id: 7955:abcc8b
uniprot id: A0A8M9P1K6
uniprot id: A0A8M9PAN8
uniprot id: A0A8M9PG34
uniprot id: A0A8M9PMX8
uniprot id: A0A8M9PR49
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with KCNJ11.
messages: Membrane

7955:zgc:171446
gene id: 7955:zgc:171446
uniprot id: A8WFS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

7955:snrnp27
gene id: 7955:snrnp27
uniprot id: Q6DH74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNUT3 family.
messages: May play a role in mRNA splicing.
messages: Nucleus
messages: Part of a tri-snRNP complex.

7955:nudt1
gene id: 7955:nudt1
uniprot id: Q7ZWC3
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Inhibited by TH588.
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool (PubMed:26862114, PubMed:30304478). Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP (PubMed:26862114). Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP (PubMed:26862114, PubMed:30304478). Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A (PubMed:26862114, PubMed:30304478). Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA (PubMed:32144205, PubMed:30304478). Through this antimutagenic activity protects cells from oxidative stress (PubMed:32144205, PubMed:26862114, PubMed:30304478).
messages: cytosol

7955:lama1
gene id: 7955:lama1
uniprot id: Q45H72
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

7955:si:ch211-197l9.4
gene id: 7955:si:ch211-197l9.4
uniprot id: A0A8M1PAB3
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

7955:scrn2
gene id: 7955:scrn2
uniprot id: Q5TYS5
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

7955:fgd4a
gene id: 7955:fgd4a
uniprot id: D5FS19
names: Subcellular Location Annotation
messages: cytoskeleton

7955:slc25a18
gene id: 7955:slc25a18
uniprot id: E7F2B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7955:tubb4b
gene id: 7955:tubb4b
uniprot id: Q6P5M9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

7955:ido1
gene id: 7955:ido1
uniprot id: A0A8M9Q3K0
uniprot id: A0A8M9Q9T3
uniprot id: A2Q0R5
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

7955:twf2
gene id: 7955:twf2
uniprot id: A0A8M2BDE1
uniprot id: Q6GMH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin (By similarity).
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: Interacts with G-actin; ADP-actin form and capping protein (CP).
messages: cytoskeleton
messages: perinuclear region

7955:slc22a31
gene id: 7955:slc22a31
uniprot id: A0A8N7TFR5
names: Subcellular Location Annotation
messages: Membrane

7955:calcrl2
gene id: 7955:calcrl2
uniprot id: A0A8M1RN40
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Interacts with GPRASP2.
messages: Membrane

7955:zdhhc3a
gene id: 7955:zdhhc3a
uniprot id: A0A8M2B4K7
uniprot id: F1RE57
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autopalmitoylated.
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Golgi apparatus membrane
messages: Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and regulates their association with membranes (Probable). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (Probable).
messages: Membrane
messages: Monomer. Homooligomers. The monomeric form has a higher catalytic activity. Forms heterooligomers with zdhhc7.
messages: Probably maternally supplied, the zygotic expression is detected early during development at the sphere stage but decreases after 7.5 hpf.
messages: The DHHC domain is required for palmitoyltransferase activity.

7955:gdf3
gene id: 7955:gdf3
uniprot id: A0A8M9PNK2
uniprot id: P35621
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundant in ovaries and eggs, and equally distributed among all blastomeres.
messages: Belongs to the TGF-beta family.
messages: Concentrated in the streaming cytoplasm in just-fertilized eggs. Evenly partitioned during cleavage among all blastomeres. Absent in the yolk cell during cleavage, blastula and gastrula stages. Distributed homogeneously among all cells of the gastrula.
messages: Homodimer.
messages: Secreted
messages: Serves to facilitate the differentiation of either mesoderm or endoderm either as a cofactor in an instructive signal or by providing permissive environment.

7955:trrap
gene id: 7955:trrap
uniprot id: A0A0R4IPE4
uniprot id: A0A0R4ITC5
uniprot id: A0A8M3B4M5
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression (By similarity). May play a role in the formation and maintenance of the auditory system (PubMed:31231791).
messages: Belongs to the PI3/PI4-kinase family. TRA1 subfamily.
messages: Morpholino TRRAP knockdown results in defects in the inner ear. Morphant larvae show reduced lateral line neuromasts, decreased number of hair cells per neuromast, and fewer and thinner stereocilia on the hair cells. In addition, the acoustic startle response is decreased and sound-induced fast escape reflex is impaired.
messages: Nucleus

7955:tceb3
gene id: 7955:tceb3
uniprot id: Q803L4
names: Subcellular Location Annotation
messages: Nucleus

7955:anapc5
gene id: 7955:anapc5
uniprot id: A0A8M1PFK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC5 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: spindle

7955:map2
gene id: 7955:map2
uniprot id: A0A8M3AW82
uniprot id: A0A8M3AW86
uniprot id: A0A8M3AW90
uniprot id: A0A8M3AW95
uniprot id: A0A8M3AW99
uniprot id: A0A8M3B2U9
uniprot id: A0A8M3B2V3
uniprot id: A0A8M3B5T7
uniprot id: A0A8M3B5U1
uniprot id: A0A8M3BCK8
uniprot id: A0A8M3BCL1
uniprot id: A0A8M9PT11
uniprot id: A0A8M9Q578
uniprot id: A0A8M9QG46
names: Subcellular Location Annotation
messages: cytoskeleton

7955:rplp2
gene id: 7955:rplp2
uniprot id: A0A8M9PZH4
uniprot id: Q6PBJ9
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

7955:calm2a
gene id: 7955:calm2a
uniprot id: Q6PI52
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the calmodulin family.
messages: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases.
messages: This protein has four functional calcium-binding sites.

7955:LOC108191642
gene id: 7955:LOC108191642
uniprot id: A0A8M6Z8U1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:lztfl1
gene id: 7955:lztfl1
uniprot id: A0A8M2BHX5
uniprot id: Q7ZV21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTFL1 family.
messages: Cytoplasm
messages: Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
messages: Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.

7955:nfil3-5
gene id: 7955:nfil3-5
uniprot id: A0A8M1NV59
uniprot id: F1QZP2
uniprot id: Q6P933
names: Similarity
messages: Belongs to the bZIP family. NFIL3 subfamily.

7955:zgc:112320
gene id: 7955:zgc:112320
uniprot id: Q502C6
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

7955:eif4a3
gene id: 7955:eif4a3
uniprot id: B2GTC1
uniprot id: Q7ZVA6
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions (By similarity). Involved in craniofacial development (PubMed:24360810).
messages: Belongs to the DEAD box helicase family.
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: Cytoplasm
messages: Identified in the spliceosome C complex. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains casc3, eif4a3, magoh and rbm8a.
messages: Morpholino EIF4A3 knockdown results in multiple defects in craniofacial structures. Fish morphants staged at 24 hpf show eyes reduced in size, and dark and opaque zones in all brain structures. In addition, the otic vesicle and the midbrain/hindbrain border regions are barely detectable. Cartilage and bone staining reveals underdevelopment of craniofacial cartilage, bone alterations, and clefting of the lower jaw. The third through sixth pharyngeal arches are underdeveloped in morphants.
messages: Nucleus
messages: Nucleus speckle

7955:si:dkey-45k15.1
gene id: 7955:si:dkey-45k15.1
uniprot id: A0A0R4IIR8
names: Similarity
messages: Belongs to the SEC6 family.

7955:tbx2b
gene id: 7955:tbx2b
uniprot id: Q7ZTU9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds DNA as a monomer.
messages: Expressed in the axial mesoderm, notably, in the notochordal precursor cells immediately before formation of the notochord and in the chordoneural hinge of the tail bud, after the notochord is formed. In addition, its expression is detected in the ventral forebrain, sensory neurons, fin buds and excretory system.
messages: Expression seen in many tissues of ectodermal and mesodermal origin during embryogenesis. First detected at bud stage in the ventral prosencephalon and along the length of the notochord. As segmentation proceeds, expressed in the optic primordia, otic placodes and diffusely in cells over the yolk lying ventrally to the tail bud. Midway through the segmentation period, expression also seen in the acostic and lateral line sensory ganglia. At 22 hpf, found in the most posterior portion of the pronephric ducts (PubMed:10664151). At the end of gastrulation, expression seen in the prospective ventral forebrain, single eye field and the presumptive notochord. At 12 hpf, expression in the midline found only at the posterior end of the notochord where it can be detected until the end of segmentation. At 20 hpf, expression in the eye is restricted to the dorsal retina and also found in the epiphysis, otic vesicles and sensory neurons of cranial ganglia. At 22 hpf, expressed in bud of pectoral fins and at 30 hpf, in a subset of interneurons in the anterior spinal cord (PubMed:10331981).
messages: Loss of atrioventricular canal formation and cardiac looping.
messages: Nucleus
messages: Transcription factor which acts as a transcriptional repressor (By similarity). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (By similarity). Involved in the transcriptional regulation of genes required for mesoderm differentiation. Plays a role in the specification of late notochordal precursor cells and formation of the differentiated notochord. Required for cardiac atrioventricular canal formation.

7955:LOC101885478
gene id: 7955:LOC101885478
uniprot id: A0A8M6Z3G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane

7955:mrps18b
gene id: 7955:mrps18b
uniprot id: Q566S7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.

7955:kif2c
gene id: 7955:kif2c
uniprot id: A9JRA8
uniprot id: B0S7G2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:elp1
gene id: 7955:elp1
uniprot id: A0A0R4IJ07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP1/IKA1 family.
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
messages: Cytoplasm
messages: Nucleus

7955:cdh7
gene id: 7955:cdh7
uniprot id: A0A8M2BAG9
uniprot id: B0S6D4
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane

7955:npy
gene id: 7955:npy
uniprot id: Q1LW93
uniprot id: Q9I8P3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
messages: Secreted

7955:LOC110438004
gene id: 7955:LOC110438004
uniprot id: A0A8M9P8L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

7955:ap4m1
gene id: 7955:ap4m1
uniprot id: A0A8M6Z1A2
uniprot id: A0A8M9QGL0
uniprot id: Q7SZZ7
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

7955:fibina
gene id: 7955:fibina
uniprot id: A0A8M1REQ1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FIBIN family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer; disulfide-linked. Seems to also exist as monomers.
messages: Secreted

7955:katnb1
gene id: 7955:katnb1
uniprot id: Q7ZUV2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat KATNB1 family.
messages: Cytoplasm
messages: Interacts with katna1. This interaction enhances the microtubule binding and severing activity of katna1 and also targets this activity to the centrosome.
messages: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
messages: Results in a significant reduction in midbrain size. A wide spectrum of defects in gastrulation and formation of anterior structures are noticed, ranging from milder microcephaly to more severe anencephaly and early embryonic death.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

7955:slc25a35
gene id: 7955:slc25a35
uniprot id: A0A8M2BCZ7
uniprot id: A3KPP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

7955:taar20t
gene id: 7955:taar20t
uniprot id: F1RCS3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:ogt.1
gene id: 7955:ogt.1
uniprot id: A0A8M3B8G4
uniprot id: Q5GA10
uniprot id: Q5GA11
uniprot id: Q5GA12
uniprot id: Q5GA13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
messages: Cell projection
messages: Mitochondrion membrane

7955:dnah9l
gene id: 7955:dnah9l
uniprot id: A0A8M9QBI1
names: Similarity
messages: Belongs to the dynein heavy chain family.

7955:bbs7
gene id: 7955:bbs7
uniprot id: Q08C18
names: Function
names: Subunit
messages: Part of BBSome complex.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.

7955:fem1c
gene id: 7955:fem1c
uniprot id: Q7T3P8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the fem-1 family.
messages: Component of a CRL2 E3 ubiquitin-protein ligase complex, also named ECS (Elongin BC-CUL2/5-SOCS-box protein) complex.
messages: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1C) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, leading to their ubiquitination and degradation.
messages: The first seven ANK repeats at the N-terminus (1-243) are essnetial for recognition of Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons.

7955:ctgfb
gene id: 7955:ctgfb
uniprot id: A5PN60
uniprot id: A6XA79
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:zgc:92791
gene id: 7955:zgc:92791
uniprot id: F1QR78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.

7955:f11r.1
gene id: 7955:f11r.1
uniprot id: Q66I72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily.
messages: Cell membrane
messages: Membrane
messages: tight junction

7955:tcf7l2
gene id: 7955:tcf7l2
uniprot id: Q71G54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

7955:LOC558704
gene id: 7955:LOC558704
uniprot id: A0A8M9PRF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

7955:si:ch211-113e8.9
gene id: 7955:si:ch211-113e8.9
uniprot id: A0A8M3AR62
uniprot id: A0A8M9Q611
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:si:dkey-40m6.14
gene id: 7955:si:dkey-40m6.14
uniprot id: A0A8M9PDP8
uniprot id: A0A8M9PN41
names: Similarity
messages: Belongs to the GST superfamily. Kappa family.

7955:irx4b
gene id: 7955:irx4b
uniprot id: Q1LWG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

7955:tnfsf10l4
gene id: 7955:tnfsf10l4
uniprot id: Q0PKX8
uniprot id: Q5EAP6
names: Similarity
messages: Belongs to the tumor necrosis factor family.

7955:dhx29
gene id: 7955:dhx29
uniprot id: A0A8N7T8I5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Cytoplasm
messages: Part of the 43S pre-initiation complex (PIC).

7955:sgsm2
gene id: 7955:sgsm2
uniprot id: A0A8M9PCC5
uniprot id: A0A8M9PNK7
names: Similarity
messages: Belongs to the RUTBC family.

7955:pvalb6
gene id: 7955:pvalb6
uniprot id: Q804W1
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

7955:pih1d3
gene id: 7955:pih1d3
uniprot id: Q6IVV7
names: Similarity
messages: Belongs to the PIH1 family.

7955:rnaseka
gene id: 7955:rnaseka
uniprot id: Q0P467
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase K family.
messages: Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds.
messages: Membrane

7955:faxca
gene id: 7955:faxca
uniprot id: E7FFZ1
names: Similarity
messages: Belongs to the FAX family.

7955:tjp1a
gene id: 7955:tjp1a
uniprot id: A0A8M2BG85
uniprot id: A0A8M2BG91
uniprot id: A0A8M3AUA1
uniprot id: A0A8M3AUA6
uniprot id: A0A8M3AUB4
uniprot id: A0A8M3B198
uniprot id: A0A8M3B1A2
uniprot id: A0A8M3B464
uniprot id: A0A8M3B467
uniprot id: A0A8M3BB23
uniprot id: A0A8M3BB27
uniprot id: A0A8M9PPT8
uniprot id: A0A8M9Q2H7
uniprot id: A0A8M9QHT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Membrane
messages: tight junction

7955:ppfia1
gene id: 7955:ppfia1
uniprot id: A9JR75
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

7955:cct6a
gene id: 7955:cct6a
uniprot id: Q7ZYX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

7955:slc25a45
gene id: 7955:slc25a45
uniprot id: A0A8M1RH87
uniprot id: A0A8M3ASZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7955:cyp2p8
gene id: 7955:cyp2p8
uniprot id: Q5TZ86
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:LOC100006895
gene id: 7955:LOC100006895
uniprot id: A0A8M1QLT2
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.

7955:trak1
gene id: 7955:trak1
uniprot id: A0A8M3AIV7
uniprot id: A0A8M3AT45
uniprot id: A0A8M3B1F5
uniprot id: A0A8M3B1F9
uniprot id: A0A8M9PMV3
uniprot id: E9QJ68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

7955:parp1
gene id: 7955:parp1
uniprot id: A0A8N1TQ38
uniprot id: Q5RHR0
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP-ribosyltransferase activity is regulated via an allosteric activation mechanism. In absence of activation signal, parp1 is autoinhibited by the PARP alpha-helical domain (also named HD region), which prevents effective NAD(+)-binding. Activity is highly stimulated by signals, such as DNA strand breaks. Binding to damaged DNA unfolds the PARP alpha-helical domain, relieving autoinhibition. Poly-ADP-ribosyltransferase activity is tightly regulated and parp1 is removed from damaged chromatin following initial poly-ADP-ribosylation of chromatin to avoid prolonged residence (trapping) that has cytotoxic consequences. A number of factors or post-translational modifications (auto-poly-ADP-ribosylation) promote parp1 removal from chromatin.
messages: Belongs to the ARTD/PARP family.
messages: Chromosome
messages: Homodimer; PARP-type zinc-fingers from separate parp1 molecules form a dimer module that specifically recognizes DNA strand breaks.
messages: Nucleus
messages: Poly-ADP-ribosylated on serine, glutamate and aspartate residues by autocatalysis. Auto-ADP-ribosylation on serine takes place following interaction with HPF1. Auto poly-ADP-ribosylation on serine residues promotes its dissociation from chromatin.
messages: Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:34798058). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (By similarity). Specificity for the different amino acids is conferred by interacting factors, such as hpf1 and nmnat1 (By similarity). Following interaction with hpf1, catalyzes serine ADP-ribosylation of target proteins; hpf1 confers serine specificity by completing the parp1 active site. Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with hpf1 (By similarity). Following interaction with nmnat1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; nmnat1 confers glutamate and aspartate specificity (By similarity). Parp1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits hpf1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks. In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair. Mediates the poly-ADP-ribosylation of a number of proteins. In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (By similarity). Parp1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neu…
messages: Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair.
messages: The BRCT domain is able to bind intact DNA without activating the poly-ADP-ribosyltransferase activity. The BRCT domain mediates DNA intrastrand transfer (named 'monkey-bar mechanism') that allows rapid movements of parp1 through the nucleus.
messages: The PADR1-type (also named Zn3) zinc-finger mediates an interdomain contact and is required for the ability of parp1 to regulate chromatin structure.
messages: The PARP alpha-helical domain (also named HD region) prevents effective NAD(+)-binding in absence of activation signal. Binding to damaged DNA unfolds the PARP alpha-helical domain, relieving autoinhibition.
messages: The WGR domain bridges two nucleosomes, with the broken DNA aligned in a position suitable for ligation. The bridging induces structural changes in parp1 that signal the recognition of a DNA break to the catalytic domain of parp1.
messages: The two PARP-type zinc-fingers (also named Zn1 and Zn2) specifically recognize DNA strand breaks: PARP-type zinc-finger 1 binds PARP-type zinc-finger 2 from a separate parp1 molecule to form a dimeric module that specifically recognizes DNA strand breaks.
messages: cytosol
messages: nucleolus

7955:si:ch211-113a14.6
gene id: 7955:si:ch211-113a14.6
uniprot id: A3KPR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:ccdc59
gene id: 7955:ccdc59
uniprot id: Q5RGP9
names: Similarity
messages: Belongs to the TAP26 family.

7955:nr2f5
gene id: 7955:nr2f5
uniprot id: B3DI15
uniprot id: Q06726
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus
messages: Putative receptor that is required in photoreceptor cells precursors during eye development.

7955:dctn1a
gene id: 7955:dctn1a
uniprot id: A0A8M9Q1C7
uniprot id: Q07DR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin 150 kDa subunit family.
messages: cell cortex
messages: cytoskeleton

7955:slc7a7
gene id: 7955:slc7a7
uniprot id: Q2YDQ4
names: Subcellular Location Annotation
messages: Membrane

7955:sult6b1
gene id: 7955:sult6b1
uniprot id: F1QYJ6
names: Activity Regulation
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family.
messages: Chimeric cDNA. Contains sequence from chromosome 22 in the C-terminus.
messages: Strongly inhibited by the divalent metal cations Fe(2+), Hg(2+), Co(2+), Zn(2+), Cu(2+) and Cd(2+).
messages: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a variety of xenobiotic and endogenous compounds, including dopamine, T3 (triiodo-L-thyronine), T4 (thyroxine), flavonoids, isoflavonoids, and other phenolic compounds.
messages: cytosol

7955:tmem87b
gene id: 7955:tmem87b
uniprot id: A0A8M9QNY0
names: Subcellular Location Annotation
messages: Membrane

7955:tub
gene id: 7955:tub
uniprot id: A0A8M2BJL8
uniprot id: A0A8M9PZ13
uniprot id: A0A8N7TDY2
uniprot id: E7F015
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

7955:gpr20
gene id: 7955:gpr20
uniprot id: A0A8M9PK33
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:twf1b
gene id: 7955:twf1b
uniprot id: Q6DKF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

7955:phf8
gene id: 7955:phf8
uniprot id: P0CH95
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.
messages: Binds 1 Fe(2+) ion per subunit.
messages: First detected at 14 hours post-fertilization (hpf) in the head and tail regions. Found mostly in the head region. Also detectable in the jaw of the embryo at 3 dpf.
messages: Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate (By similarity). Required for brain development, probably by regulating expression of neuron-specific genes.
messages: Morpholino knockdown of the protein results in defects in brain and craniofacial development. Embryos show delays in brain development at 24 hpf and apoptosis in the developing brain and the neural tube at 30 hpf.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3. Binding to H3K4me3 promotes its access to H3K9me2 (By similarity).
messages: The linker region is a critical determinant of demethylase specificity. It enables the active site of JmjC to reach the target H3K9me2 when the PHD-type zinc finger binds to H3K4me3 (By similarity).
messages: nucleolus

7955:npl
gene id: 7955:npl
uniprot id: A9C3P6
names: Similarity
names: Subunit
messages: Belongs to the DapA family.
messages: Homotetramer.

7955:galnt8b.1
gene id: 7955:galnt8b.1
uniprot id: A0A8M9QC69
uniprot id: F1R0I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

7955:crp6
gene id: 7955:crp6
uniprot id: A3KPH6
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:otub1a
gene id: 7955:otub1a
uniprot id: Q6DH16
names: Similarity
messages: Belongs to the peptidase C65 family.

7955:icmt
gene id: 7955:icmt
uniprot id: Q568J7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:ptpn6
gene id: 7955:ptpn6
uniprot id: A0A2R8Q2T0
uniprot id: E7F3D4
uniprot id: Q803M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

7955:lyn
gene id: 7955:lyn
uniprot id: A0A8M2BAN0
uniprot id: Q66I04
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

7955:adam23a
gene id: 7955:adam23a
uniprot id: A0A8M2BD47
uniprot id: F8W3T1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:lamb2
gene id: 7955:lamb2
uniprot id: A0A8M2B8V2
uniprot id: B7ZDA6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

7955:anxa4
gene id: 7955:anxa4
uniprot id: Q804G7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Zymogen granule membrane

7955:ivns1abpb
gene id: 7955:ivns1abpb
uniprot id: Q7ZVQ8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats.
messages: cytoskeleton

7955:tmem65
gene id: 7955:tmem65
uniprot id: B3DHU2
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Expression is restricted to the heart (at protein level).
messages: May play an important role in cardiac development and function. May regulate cardiac conduction and the function of the gap junction protein GJA1. May contribute to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication (PubMed:26403541). Regulates mitochondrial respiration and mitochondrial DNA copy number maintenance (By similarity).
messages: Mitochondrion inner membrane
messages: Monomer. Homodimer. Interacts with GJA1.
messages: Morpholino knockdown of the protein causes pericardial edema and altered cardiac morphology in 4 days post-fertilization (dpf) embryos and severity increases as embryos age. Morrphants are not viable by 7 dpf. Hearts showed abnormal cardiac looping in the morphants and a significant decline in heart beat rates seen in after 4.5 dpf and continue decreasing at 5 and 6 dpf. Ventricles show a significant reduction in amplitude of Ca(2+) transients in morphants between 4 and 6 dpf.

7955:tmem14ca
gene id: 7955:tmem14ca
uniprot id: A0A8M2B9G8
uniprot id: Q0P436
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM14 family.
messages: Membrane
messages: Morpholino knockdown of the protein results in profound anemia without affecting erythroid specification.
messages: Required for normal heme biosynthesis.

7955:cenpe
gene id: 7955:cenpe
uniprot id: A0A8M2BFG2
uniprot id: A0A8M2BFG4
uniprot id: A0A8M6YXU4
uniprot id: E7F2U4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:tmeff1a
gene id: 7955:tmeff1a
uniprot id: A0A8M3B0F6
uniprot id: A0A8N7TE40
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:dimt1l
gene id: 7955:dimt1l
uniprot id: F1QJ20
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

7955:shank1
gene id: 7955:shank1
uniprot id: A0A8M9P8G4
uniprot id: A0A8M9PEY7
uniprot id: A0A8M9PJG1
uniprot id: A0A8M9PQE5
uniprot id: A0A8M9PQF3
uniprot id: A0A8M9PRS2
uniprot id: A0A8M9Q129
uniprot id: A0A8M9Q8Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cytoplasm
messages: Postsynaptic density

7955:apooa
gene id: 7955:apooa
uniprot id: Q3B747
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

7955:LOC103909543
gene id: 7955:LOC103909543
uniprot id: A0A8M3AM44
names: Similarity
messages: Belongs to the tumor necrosis factor family.

7955:si:rp71-1d10.5
gene id: 7955:si:rp71-1d10.5
uniprot id: A0A8M1P9Z5
names: Subcellular Location Annotation
messages: Membrane

7955:leg1.2
gene id: 7955:leg1.2
uniprot id: Q4QRF7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the LEG1 family.
messages: Detected in all tissues tested, with the highest levels in serum (at protein level). At mRNA level, only expressed in liver.
messages: Expressed as early as 24 hours post fecondation (hpf), expressed at lower levels than leg1a.
messages: Involved in early development of liver, exocrine pancreas and intestine, probably through cell cycle regulation. In liver, its function is partially redundant with leg1a function.
messages: Morpholino knockdown of the protein causes a small liver phenotype. Morpholino which can simultaneously block the translation of leg1a and leg1b, causes a more severe small liver phenotype with hypoplastic exocrine pancreas and intestinal tube as well.
messages: Secreted

7955:carkd
gene id: 7955:carkd
uniprot id: A0A8M2BET0
uniprot id: A0A8M2BEU4
uniprot id: A0A8M2BEU7
uniprot id: A0A8M2BEW7
uniprot id: A0A8M2BEY3
uniprot id: A0A8M2BFH6
uniprot id: A8KB11
uniprot id: E7F490
uniprot id: F1Q575
names: Function
names: Similarity
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.

7955:spata6l
gene id: 7955:spata6l
uniprot id: Q7T2B2
names: Similarity
messages: Belongs to the SPATA6 family.

7955:sod3b
gene id: 7955:sod3b
uniprot id: E9QIM2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

7955:btg3
gene id: 7955:btg3
uniprot id: A0A2R8QIP9
uniprot id: Q5U3I9
names: Similarity
messages: Belongs to the BTG family.

7955:dnal4b
gene id: 7955:dnal4b
uniprot id: Q503Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

7955:lpin1
gene id: 7955:lpin1
uniprot id: B3DIU0
uniprot id: Q14EB8
uniprot id: X1WH54
names: Similarity
messages: Belongs to the lipin family.

7955:klhl41b
gene id: 7955:klhl41b
uniprot id: F1QEG2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Expression is predominantly seen in striated muscles, and strong expression in heart and skeletal muscles is observed throughout development to at least 5 dpf.
messages: Involved in skeletal muscle development and maintenance.
messages: Knockdown of klhl41b result in reduced disorganized muscle without any other significant abnormalities. Knockdown of both genes (klhl41a and klhl41b) is lethal by 3 dpf. Double knockdown fish exhibit severely disorganized muscle compared to controls and either of the single knockdowns.
messages: Sarcoplasmic reticulum membrane
messages: cytoskeleton

7955:si:dkey-108k21.21
gene id: 7955:si:dkey-108k21.21
uniprot id: A0A8M2BI26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

7955:sh3bp5b
gene id: 7955:sh3bp5b
uniprot id: Q803L6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

7955:si:rp71-1c10.10
gene id: 7955:si:rp71-1c10.10
uniprot id: A0A8M6Z9E1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:chia.1
gene id: 7955:chia.1
uniprot id: Q7ZVF1
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

7955:LOC108180715
gene id: 7955:LOC108180715
uniprot id: A0A8M9PIH6
names: Similarity
messages: Belongs to the cullin family.

7955:crybb1l2
gene id: 7955:crybb1l2
uniprot id: A7E2K5
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:ppp2r2ba
gene id: 7955:ppp2r2ba
uniprot id: A0A0R4IJA2
uniprot id: A0A8M9PZZ4
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

7955:zfpm2b
gene id: 7955:zfpm2b
uniprot id: B2GM63
uniprot id: Q2QKJ8
names: Subcellular Location Annotation
messages: Nucleus

7955:si:dkey-222n6.2
gene id: 7955:si:dkey-222n6.2
uniprot id: A0A8M1RNJ0
names: Similarity
messages: Belongs to the intermediate filament family.

7955:nrf1
gene id: 7955:nrf1
uniprot id: Q90X44
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NRF1/Ewg family.
messages: Expressed in the developing eye and CNS prior to neuronal differentiation. First detected at around 18 hours post-fertilization (hpf) in the eye primordia and brain. At 24-42 hpf, expressed in most cells of the developing eyes, CNS and ears. At 48 hpf, also detected in the optic nerve and tracts. By 56 hpf, levels are barely detectable.
messages: Homodimer. Binds DNA as a dimer (By similarity).
messages: Nucleus
messages: Probable transcription factor that is required for normal development of the outer retina.

7955:rfx1b
gene id: 7955:rfx1b
uniprot id: A0A8M9Q7I5
uniprot id: A0A8M9QBM6
names: Subcellular Location Annotation
messages: Nucleus

7955:gng3
gene id: 7955:gng3
uniprot id: Q90Z40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

7955:entpd2a.1
gene id: 7955:entpd2a.1
uniprot id: Q66L64
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

7955:cubn
gene id: 7955:cubn
uniprot id: A0A8M9PME6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:stk32a
gene id: 7955:stk32a
uniprot id: A0A8M1RMM6
uniprot id: A0A8M3B519
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:col4a2
gene id: 7955:col4a2
uniprot id: A0A8M6Z838
uniprot id: A0A8M9QB43
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

7955:si:dkey-10f23.2
gene id: 7955:si:dkey-10f23.2
uniprot id: A0A1D5NSC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NFX1 family.
messages: Nucleus

7955:frem3
gene id: 7955:frem3
uniprot id: B6IDE8
names: Similarity
messages: Belongs to the FRAS1 family.

7955:rdh10b
gene id: 7955:rdh10b
uniprot id: B2GPJ5
uniprot id: Q7T2D1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity).

7955:tmlhe
gene id: 7955:tmlhe
uniprot id: E7F0M9
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

7955:vps36
gene id: 7955:vps36
uniprot id: Q7ZVK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II), composed of SNF8, VPS25 and VPS36.
messages: Cytoplasm
messages: Endosome

7955:bicd2
gene id: 7955:bicd2
uniprot id: A0A8N7TEB8
uniprot id: X1WDT9
names: Similarity
messages: Belongs to the BicD family.

7955:cdc14b
gene id: 7955:cdc14b
uniprot id: A0A8M2BE31
uniprot id: A0A8M2BE48
uniprot id: A0A8M2BE70
uniprot id: A0A8M9Q9K5
uniprot id: A0A8M9QII0
uniprot id: F8W2B2
uniprot id: Q7ZVN3
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

7955:LOC103910251
gene id: 7955:LOC103910251
uniprot id: A0A8M6Z5H7
names: Subcellular Location Annotation
messages: Nucleus

7955:dusp4
gene id: 7955:dusp4
uniprot id: Q7SZF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

7955:phlda1
gene id: 7955:phlda1
uniprot id: Q5XJ33
names: Subcellular Location Annotation
messages: Cytoplasm

7955:gpd1b
gene id: 7955:gpd1b
uniprot id: Q7T1E0
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

7955:vtg6
gene id: 7955:vtg6
uniprot id: A0A8M1NG90
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:nxpe3
gene id: 7955:nxpe3
uniprot id: Q08BN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXPE family.
messages: Secreted

7955:rpl15
gene id: 7955:rpl15
uniprot id: Q6DHS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

7955:spire2
gene id: 7955:spire2
uniprot id: E7EZ28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spire family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytoskeleton

7955:sdr16c5b
gene id: 7955:sdr16c5b
uniprot id: Q7SZ49
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:or115-15
gene id: 7955:or115-15
uniprot id: Q90428
names: Subcellular Location Annotation
messages: Membrane

7955:ccdc113
gene id: 7955:ccdc113
uniprot id: Q5XJN6
names: Function
names: Subcellular Location Annotation
messages: May be involved in primary cilium formation.
messages: centriolar satellite

7955:tuba8l4
gene id: 7955:tuba8l4
uniprot id: Q7ZVI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

7955:zgc:110425
gene id: 7955:zgc:110425
uniprot id: Q503M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

7955:tmem138
gene id: 7955:tmem138
uniprot id: E7FDE0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM138 family.
messages: Ciliary phenotypes such as pericardial effusion, curved or kinked tail, as well as gastrulation defects.
messages: Required for ciliogenesis.
messages: Vacuole membrane
messages: cilium

7955:si:ch211-130m23.3
gene id: 7955:si:ch211-130m23.3
uniprot id: A0A8M3B9V2
uniprot id: A0A8M6Z6W7
uniprot id: A2BIP9
names: Subcellular Location Annotation
messages: Nucleus

7955:xkr6b
gene id: 7955:xkr6b
uniprot id: F1R8C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

7955:gdpd4a
gene id: 7955:gdpd4a
uniprot id: A0A8M1RRL9
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

7955:pard3bb
gene id: 7955:pard3bb
uniprot id: A0A8M3B2I8
uniprot id: A0A8M9QK08
uniprot id: A0A8N7UUX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR3 family.
messages: Cell junction
messages: Endomembrane system

7955:LOC110438373
gene id: 7955:LOC110438373
uniprot id: A0A8M9PYJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

7955:zic6
gene id: 7955:zic6
uniprot id: A0A8M3AGN3
uniprot id: Q6PWU7
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

7955:LOC100535208
gene id: 7955:LOC100535208
uniprot id: A0A8M1RLY1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

7955:gbe1a
gene id: 7955:gbe1a
uniprot id: A0A2R8QQ91
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

7955:sap130a
gene id: 7955:sap130a
uniprot id: A0A8M2BD75
uniprot id: A0A8M3ATE0
uniprot id: A0A8M6YZH6
uniprot id: F1REK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAP130 family.
messages: Nucleus

7955:dhrs13a.3
gene id: 7955:dhrs13a.3
uniprot id: Q5U3R4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:mxg
gene id: 7955:mxg
uniprot id: A0A8M3APM4
uniprot id: Q800G3
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

7955:esr2b
gene id: 7955:esr2b
uniprot id: A0A8M2B359
uniprot id: B8JJL3
uniprot id: Q5PR29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

7955:rpf1
gene id: 7955:rpf1
uniprot id: A0A0R4IWG2
uniprot id: A0A2R8QNF3
names: Subcellular Location Annotation
messages: nucleolus

7955:hmgn2
gene id: 7955:hmgn2
uniprot id: Q3B732
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

7955:sumf2
gene id: 7955:sumf2
uniprot id: Q5XJ75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

7955:jak2b
gene id: 7955:jak2b
uniprot id: A0A8M6Z6T4
uniprot id: C0RW38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
messages: Endomembrane system

7955:vps16
gene id: 7955:vps16
uniprot id: A5D6T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS16 family.
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: Vesicle

7955:nr2e3
gene id: 7955:nr2e3
uniprot id: Q5U3F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

7955:ap1m2
gene id: 7955:ap1m2
uniprot id: F1R3L9
uniprot id: Q6TLG2
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

7955:chrna5
gene id: 7955:chrna5
uniprot id: A0A8M9P128
uniprot id: Q567Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:ora4
gene id: 7955:ora4
uniprot id: A0A0R4IP11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Highly expressed in the olfactory rosette (PubMed:17717047). Specifically localizes to crypt neurons in the olfactory neuroepithelium (PubMed:22038944). Colocalizes with the inhibitory G-protein gnaia in crypt neurons (PubMed:22038944). Not detected in other tissues tested (PubMed:17717047).
messages: Probable olfactory receptor.

7955:si:dkeyp-67a8.2
gene id: 7955:si:dkeyp-67a8.2
uniprot id: B0S636
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL family.
messages: Membrane

7955:fam20cb
gene id: 7955:fam20cb
uniprot id: A0A8M9QJ44
names: Similarity
messages: Belongs to the FAM20 family.

7955:mtor
gene id: 7955:mtor
uniprot id: Q06RG6
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

7955:dohh
gene id: 7955:dohh
uniprot id: Q7ZUX6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine hydroxylase family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.

7955:rgma
gene id: 7955:rgma
uniprot id: Q1LVM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

7955:psmc1b
gene id: 7955:psmc1b
uniprot id: Q6IQ72
names: Similarity
messages: Belongs to the AAA ATPase family.

7955:tm2d2
gene id: 7955:tm2d2
uniprot id: Q6DHN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM2 family.
messages: Membrane

7955:ccser1
gene id: 7955:ccser1
uniprot id: A0A8M9Q3Y9
uniprot id: A0A8M9QA51
names: Similarity
messages: Belongs to the CCSER family.

7955:mxra8b
gene id: 7955:mxra8b
uniprot id: B0CLV0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:insig1
gene id: 7955:insig1
uniprot id: B2GRG1
uniprot id: Q8AV61
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the INSIG family.
messages: Binds oxysterols in a pocket within their transmembrane domains and interacts with SCAP via transmembrane domains 3 and 4.
messages: Endoplasmic reticulum membrane
messages: Interacts with scap; interaction is direct and only takes place in the presence of sterols; it prevents interaction between scap and the coat protein complex II (COPII). Associates with the SCAP-SREBP complex; association is mediated via its interaction with scap and only takes place in the presence of sterols.
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane
messages: Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of scap and degradation of hmgcr. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs). Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with scap and retention of the SCAP-SREBP complex in the endoplasmic reticulum. In presence of oxysterol, interacts with scap, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing scap from escorting SREBPs to the Golgi. Sterol deprivation reduces oxysterol-binding, disrupting the interaction between insig1 and scap, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBPs. Also regulates cholesterol synthesis by regulating degradation of hmgcr.
messages: The KxHxx motif mediates association with the coatomer complex.

7955:fcf1
gene id: 7955:fcf1
uniprot id: Q568H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

7955:LOC101885037
gene id: 7955:LOC101885037
uniprot id: A0A8M9Q1A7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

7955:chchd6a
gene id: 7955:chchd6a
uniprot id: A0A8M6Z3Q6
uniprot id: Q63ZW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex (also known as MINOS or MitOS complex).
messages: Membrane
messages: Mitochondrion inner membrane

7955:prune
gene id: 7955:prune
uniprot id: E7F6P6
names: Similarity
messages: Belongs to the PPase class C family. Prune subfamily.

7955:ecrg4b
gene id: 7955:ecrg4b
uniprot id: A0A5H1ZRH7
uniprot id: A0A8M9QFK1
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the augurin family.
messages: Cytoplasm
messages: Membrane
messages: Secreted

7955:slc25a36a
gene id: 7955:slc25a36a
uniprot id: A0A8M9PVM4
uniprot id: A0A8M9QDS2
uniprot id: B2GNU1
uniprot id: Q6DG32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

7955:ar
gene id: 7955:ar
uniprot id: A0A8M2BJ05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

7955:LOC566646
gene id: 7955:LOC566646
uniprot id: A0A8M2BAQ2
uniprot id: A0A8M2BAT7
uniprot id: A0A8M2BAX7
uniprot id: A0A8N7TEB6
names: Similarity
messages: Belongs to the HARBI1 family.

7955:rab14l
gene id: 7955:rab14l
uniprot id: Q6PE19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Recycling endosome
messages: phagosome
messages: trans-Golgi network membrane

7955:si:ch73-206p6.1
gene id: 7955:si:ch73-206p6.1
uniprot id: X1WGC6
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

7955:pfn1
gene id: 7955:pfn1
uniprot id: E7F0A1
names: Similarity
messages: Belongs to the profilin family.

7955:si:dkey-40g16.6
gene id: 7955:si:dkey-40g16.6
uniprot id: F1QRA1
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

7955:sulf2a
gene id: 7955:sulf2a
uniprot id: A0A8M2BGI3
uniprot id: A0A8M9QHJ3
uniprot id: A0A8M9QLI6
uniprot id: Q7ZVU8
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

7955:mrpl20
gene id: 7955:mrpl20
uniprot id: Q0P478
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.

7955:atp8b1
gene id: 7955:atp8b1
uniprot id: E7FFK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

7955:dnaaf2
gene id: 7955:dnaaf2
uniprot id: Q499A3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIH1 family. Kintoun subfamily.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.

7955:gpcpd1
gene id: 7955:gpcpd1
uniprot id: A0A8M3AWH0
uniprot id: A0A8M9PHA0
uniprot id: A0A8M9PSM9
uniprot id: Q1LVM1
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

7955:fam208ab
gene id: 7955:fam208ab
uniprot id: E7EZC0
names: Similarity
messages: Belongs to the TASOR family.

7955:ctsz
gene id: 7955:ctsz
uniprot id: Q5XJD4
names: Similarity
messages: Belongs to the peptidase C1 family.

7955:si:dkey-10o6.2
gene id: 7955:si:dkey-10o6.2
uniprot id: A0A8M9P9V2
uniprot id: A7E280
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

7955:stim1b
gene id: 7955:stim1b
uniprot id: A0A0R4IAT9
uniprot id: A0A8M1P2M0
uniprot id: F1R6G6
names: Subcellular Location Annotation
messages: Membrane

7955:slc25a36b
gene id: 7955:slc25a36b
uniprot id: X1WCX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7955:gpm6aa
gene id: 7955:gpm6aa
uniprot id: Q8UUT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

7955:hapln2
gene id: 7955:hapln2
uniprot id: A4JYQ1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:sh3rf2
gene id: 7955:sh3rf2
uniprot id: A0A8M9QGN1
names: Similarity
messages: Belongs to the SH3RF family.

7955:maml3
gene id: 7955:maml3
uniprot id: A0A8M2B6W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mastermind family.
messages: Nucleus speckle

7955:tmbim1a
gene id: 7955:tmbim1a
uniprot id: X1WGS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

7955:bzw2
gene id: 7955:bzw2
uniprot id: A0A8M9PN66
uniprot id: Q1LUC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BZW family.
messages: Cytoplasm
messages: Translation initiation regulator which may repress non-AUG initiated translation and repeat-associated non-AUG (RAN) initiated translation by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function.

7955:efemp2b
gene id: 7955:efemp2b
uniprot id: Q5WQV6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:grhl1
gene id: 7955:grhl1
uniprot id: A0A286YAF2
uniprot id: A0A8M6YT08
uniprot id: A0A8M9P024
uniprot id: E7FCE3
names: Subcellular Location Annotation
messages: Nucleus

7955:tmco4
gene id: 7955:tmco4
uniprot id: A0A8M9PFN0
uniprot id: E7F6A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMCO4 family.
messages: Membrane

7955:LOC108190101
gene id: 7955:LOC108190101
uniprot id: A0A8M9PYY6
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:si:ch211-210c8.6
gene id: 7955:si:ch211-210c8.6
uniprot id: A0A8M9PFL7
names: Subcellular Location Annotation
messages: Membrane

7955:krt1-c5
gene id: 7955:krt1-c5
uniprot id: A0A8M3B016
uniprot id: Q08C23
names: Similarity
messages: Belongs to the intermediate filament family.

7955:six3b
gene id: 7955:six3b
uniprot id: O73709
names: Subcellular Location Annotation
messages: Nucleus

7955:nrxn1a
gene id: 7955:nrxn1a
uniprot id: A0A140TAU1
uniprot id: A0A2R8QKE7
uniprot id: A0A8M2B276
uniprot id: A0A8M3AY99
uniprot id: A0A8M3AYC2
uniprot id: A0A8M3AYC5
uniprot id: A0A8M3AYD0
uniprot id: A0A8M3B4K7
uniprot id: A0A8M3B4L1
uniprot id: A0A8M3B4L5
uniprot id: A0A8M3B7D6
uniprot id: A0A8M3B7E0
uniprot id: A0A8M3B7E5
uniprot id: A0A8M3BE52
uniprot id: A0A8M3BE54
uniprot id: A0A8M3BE57
uniprot id: A0A8M9PWG1
uniprot id: A0A8M9Q8I0
uniprot id: A0A8M9Q8I6
uniprot id: A0A8M9QED3
uniprot id: A0A8M9QED6
uniprot id: A0A8M9QIT3
uniprot id: A0A8M9QIT8
uniprot id: A0A8M9QIU1
uniprot id: A0A8M9QML0
uniprot id: A0A8M9QML2
uniprot id: A1XQX0
uniprot id: A1XQX1
uniprot id: B6EUL5
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: After the very early developmental stages, the expression levels decrease and remain relatively constant until around 24 h, with the onset of an increase of expression that continues till the larval stages.
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.
messages: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in formation or maintenance of synaptic junctions.

7955:tas2r3
gene id: 7955:tas2r3
uniprot id: A6P6V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

7955:LOC110439840
gene id: 7955:LOC110439840
uniprot id: A0A8M9PZB7
names: Similarity
messages: Belongs to the DDRGK1 family.

7955:cyfip2
gene id: 7955:cyfip2
uniprot id: A0A8M3AP56
uniprot id: A0A8M3AS06
uniprot id: A5A5E1
uniprot id: B3DIT1
names: Similarity
messages: Belongs to the CYFIP family.

7955:mctp1b
gene id: 7955:mctp1b
uniprot id: A0A0R4IF57
uniprot id: A0A8M1RRA4
names: Subcellular Location Annotation
messages: Membrane

7955:ca10a
gene id: 7955:ca10a
uniprot id: Q3B739
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

7955:crybb1
gene id: 7955:crybb1
uniprot id: Q6DGZ8
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:tmem121a
gene id: 7955:tmem121a
uniprot id: E7F5Q9
names: Similarity
messages: Belongs to the TMEM121 family.

7955:ercc6l
gene id: 7955:ercc6l
uniprot id: A2BGR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Chromosome
messages: DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro).
messages: centromere
messages: kinetochore

7955:e4f1
gene id: 7955:e4f1
uniprot id: Q4V8R6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May function as a transcriptional repressor. May also function as a ubiquitin ligase. Functions in cell survival and proliferation through control of the cell cycle.
messages: nucleoplasm

7955:svep1
gene id: 7955:svep1
uniprot id: A0A1D5NSM8
uniprot id: A0A8M3AU46
uniprot id: A0A8M3B423
uniprot id: A0A8M3BAY6
uniprot id: A0A8M9Q8H8
uniprot id: A0A8M9QHN0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:itm2ca
gene id: 7955:itm2ca
uniprot id: Q6DGT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

7955:zgc:114173
gene id: 7955:zgc:114173
uniprot id: Q4V8S7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

7955:atp7a
gene id: 7955:atp7a
uniprot id: F1QEG1
uniprot id: Q4F8H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane
messages: trans-Golgi network membrane

7955:or103-2
gene id: 7955:or103-2
uniprot id: Q2PRC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:si:ch211-113a14.26
gene id: 7955:si:ch211-113a14.26
uniprot id: E7EXD7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:ndufaf2
gene id: 7955:ndufaf2
uniprot id: A9C3R5
names: Similarity
messages: Belongs to the complex I NDUFA12 subunit family.

7955:slc4a2b
gene id: 7955:slc4a2b
uniprot id: A9NIM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Membrane

7955:adgrf11
gene id: 7955:adgrf11
uniprot id: E7FF72
names: Subcellular Location Annotation
messages: Membrane

7955:zgc:65894
gene id: 7955:zgc:65894
uniprot id: Q6PE34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

7955:LOC110440037
gene id: 7955:LOC110440037
uniprot id: A0A0R4INH3
names: Subcellular Location Annotation
messages: Nucleus

7955:si:ch211-173a9.6
gene id: 7955:si:ch211-173a9.6
uniprot id: A0A8N7TFN7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:boka
gene id: 7955:boka
uniprot id: A0A8M2BDC2
uniprot id: F8W479
names: Similarity
messages: Belongs to the Bcl-2 family.

7955:dsg2.1
gene id: 7955:dsg2.1
uniprot id: H2EQR6
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (By similarity). Required for embryogenesis, specifically for progression of epiboly and normal convergence-extension movements during gastrulation (PubMed:22235774).
messages: Expressed at fertilization and up to 2 hours post-fertilization (hpf), expression then declines to low levels at 4 hpf before increasing at 6 hpf onwards until 96 hpf.
messages: Morpholino knockdowns show increased embryonic lethality, with embryos that die developing one of two clear phenotypes following developmental arrest at 10 hpf (PubMed:22235774). The first group show severe epiboly arrest with the desmosomal cadherins and enveloping layer becoming detached from the external yolk syncytial layer that continues to undergo epiboly (PubMed:22235774). This results in a population of cells at the animal pole which maintain cell division and some gastrulation movements (PubMed:22235774). In the second phenotype the enveloping layer is attached to the yolk but does not progress through epiboly (PubMed:22235774). The enveloping layer remains attached in a ring to the base of the blastoderm until embryos arrest due to mechanical stress and detachment of the blastoderm from the yolk cell following extensive proliferation and blastoderm growth (PubMed:22235774). Embryos that survive to 14 hpf show morphological defects characteristic of altered gastrulation movements including a shorter embryonic axis, undulating notochord and somites that show either altered morphology or substantial disorganization (PubMed:22235774).
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
messages: desmosome

7955:si:dkey-47k20.4
gene id: 7955:si:dkey-47k20.4
uniprot id: A0A2R8QHT6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:emc3
gene id: 7955:emc3
uniprot id: Q7SXW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Localized to the inner segment and synapse in photoreceptor cells.
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.

7955:pou6f2
gene id: 7955:pou6f2
uniprot id: A0A0R4J6S2
uniprot id: A0A8M9PGB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

7955:spty2d1
gene id: 7955:spty2d1
uniprot id: A0A8M6YWI0
uniprot id: F1R3H5
names: Similarity
messages: Belongs to the SPT2 family.

7955:abo
gene id: 7955:abo
uniprot id: B0S7I1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Membrane

7955:ppp1cb
gene id: 7955:ppp1cb
uniprot id: Q1JPZ8
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.

7955:praf2
gene id: 7955:praf2
uniprot id: Q561T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

7955:zc3h12b
gene id: 7955:zc3h12b
uniprot id: A0A8M2BCG1
uniprot id: A0A8M9Q9A6
uniprot id: A0A8M9QEJ2
names: Similarity
messages: Belongs to the ZC3H12 family.

7955:dock2
gene id: 7955:dock2
uniprot id: A0A8M1RM83
names: Similarity
messages: Belongs to the DOCK family.

7955:kdm4aa
gene id: 7955:kdm4aa
uniprot id: A0A8M2BCZ2
uniprot id: I3ITH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM3 histone demethylase family.
messages: Nucleus

7955:ywhah
gene id: 7955:ywhah
uniprot id: Q7T3G2
names: Similarity
names: Subunit
messages: Belongs to the 14-3-3 family.
messages: Homodimer, and heterodimer with other family members.

7955:LOC100535338
gene id: 7955:LOC100535338
uniprot id: A0A2R8QPY7
names: Subcellular Location Annotation
messages: Nucleus

7955:hhatlb
gene id: 7955:hhatlb
uniprot id: F1QYT4
names: Subcellular Location Annotation
messages: Membrane

7955:myt1la
gene id: 7955:myt1la
uniprot id: A0A8M2B7M3
uniprot id: A0A8M3ALM3
uniprot id: A0A8M9P2M7
uniprot id: Q5TZG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

7955:rp2
gene id: 7955:rp2
uniprot id: F1QC45
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane (By similarity). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization (By similarity). In the retina, required for maintenance of rod and cone photoreceptor cells (PubMed:26034134). May have a role in normal retinal localization of the transducins GNB1 and GNAT1, and the rhodopsin kinase GRK1 (PubMed:26034134).
messages: Belongs to the TBCC family.
messages: Cell membrane
messages: Contaminating sequence. Sequence of unknown origin at the N terminus.
messages: Expressed throughout development.
messages: In the retina, detected in both rod and cone photoreceptors (at protein level) (PubMed:21282572, PubMed:26034134). Has strongest expression in the retinal outer nuclear layer (ONL) and weaker expression in the outer plexiform layer (OPL) and inner plexiform layer (IPL) (at protein level) (PubMed:26034134). Expressed in all tissues tested (PubMed:21282572).
messages: Myristoylated on Gly-2; which may be required for membrane targeting.
messages: Palmitoylated on Cys-3; which may be required for plasma membrane targeting.
messages: Viable and fertile. Early retinal development appears to be grossly normal. Outer segments of rod and cone photoreceptors show progressive degeneration from 2 months of age, with rod cells more severely affected in the early stages.
messages: cilium

7955:asxl2
gene id: 7955:asxl2
uniprot id: E7FG88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Asx family.
messages: Nucleus

7955:si:dkey-88n24.11
gene id: 7955:si:dkey-88n24.11
uniprot id: A0A140LH15
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:pcdh2g8
gene id: 7955:pcdh2g8
uniprot id: I6LD75
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

7955:ano5a
gene id: 7955:ano5a
uniprot id: A0A8M3APA6
uniprot id: A0A8M9P700
uniprot id: A0A8M9PHI6
uniprot id: A0A8M9PZA0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:lars2
gene id: 7955:lars2
uniprot id: A7MBM0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

7955:atp6v1aa
gene id: 7955:atp6v1aa
uniprot id: Q7SY46
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

7955:abcc8
gene id: 7955:abcc8
uniprot id: A0A8M1NTE0
uniprot id: A0A8M3AP51
uniprot id: F1QMZ9
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with KCNJ11.
messages: Membrane

7955:prdm14
gene id: 7955:prdm14
uniprot id: F1QWQ9
uniprot id: Q6XSK8
names: Subcellular Location Annotation
messages: Nucleus

7955:ccnf
gene id: 7955:ccnf
uniprot id: Q6NYX6
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Component of the SCF(CCNF) complex.
messages: Expressed in the brain.
messages: Initially ubiquitous expression at 12 hours post-fertilization (hpf), then strongly expressed in the central nervous system by 48 hpf (PubMed:28444311). Strongly expressed in the brain up to 5 days post-fertilization (dpf) (PubMed:28444311). Ongoing expression in whole brain tissue beyond 5 dpf into adulthood (PubMed:28444311).
messages: Nucleus
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The SCF(CCNF) E3 ubiquitin-protein ligase complex is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle (By similarity). Mediates the substrate recognition and the proteasomal degradation of various target proteins during G2 phase involved in the regulation of cell cycle progression and in the maintenance of genome stability (By similarity). May play a role in motor neuron development and axonal outgrowth (PubMed:28444311).
messages: The D box motifs (amino acid sequence RxxL) are involved in substrate binding, and may be ubiquitinated.
messages: The nuclear localization signals mediate the localization to the nucleus.
messages: centriole
messages: perinuclear region

7955:gpr161
gene id: 7955:gpr161
uniprot id: Q90X46
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Embryos exhibit perturb cardiac looping as the result of a defect in left/right patterning.
messages: Expressed throughout embryonic development. At 9- to 16-somites, transcripts are broadly expressed with specific staining observed in the developing nervous system, somites, and precardiac mesoderm. At later stages 1- to 3-days post-fertilization, transcripts become more localized within the dorsal diencephalon, the otic vesicles, and the fin buds.
messages: Key negative regulator of Shh signaling during neural tube development. Recruited to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of gli3 into gli3r and repress the Shh signaling. In presence of shh, it is removed from primary cilia, preventing its activity and allowing activation of the Shh signaling (By similarity). Required in left/right patterning by modulating Ca(2+) levels in the cells surrounding the Kupffer vesicle.
messages: cilium membrane

7955:fmnl1a
gene id: 7955:fmnl1a
uniprot id: I3ITQ8
names: Similarity
messages: Belongs to the formin homology family.

7955:or125-7
gene id: 7955:or125-7
uniprot id: Q2PRA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:sec22a
gene id: 7955:sec22a
uniprot id: F1QBW3
uniprot id: Q7ZW89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

7955:ephb3
gene id: 7955:ephb3
uniprot id: A0A8M9PSM0
names: Subcellular Location Annotation
messages: Membrane

7955:LOC799279
gene id: 7955:LOC799279
uniprot id: E7FGC6
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

7955:lix1l
gene id: 7955:lix1l
uniprot id: A0A8M2B6G9
uniprot id: A3KQR9
names: Similarity
messages: Belongs to the LIX1 family.

7955:chmp4bb
gene id: 7955:chmp4bb
uniprot id: B2GRA4
uniprot id: Q6IQ73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Late endosome membrane
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage (By similarity).
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome (By similarity).
messages: cytosol

7955:hps5
gene id: 7955:hps5
uniprot id: F6NLH0
uniprot id: Q0VA83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPS5 family.
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: cytosol

7955:ip6k1
gene id: 7955:ip6k1
uniprot id: F1RE97
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

7955:si:ch73-267c23.10
gene id: 7955:si:ch73-267c23.10
uniprot id: A0A8M1RMA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

7955:atp9a
gene id: 7955:atp9a
uniprot id: A0A8M2BLD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

7955:uck1
gene id: 7955:uck1
uniprot id: Q66I71
names: Function
names: Similarity
messages: Belongs to the uridine kinase family.
messages: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor.

7955:ip6k2a
gene id: 7955:ip6k2a
uniprot id: A0A8M9QA58
uniprot id: Q6PBN6
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

7955:itpk1b
gene id: 7955:itpk1b
uniprot id: X1WEB0
names: Similarity
messages: Belongs to the ITPK1 family.

7955:cpxm1b
gene id: 7955:cpxm1b
uniprot id: A0A0R4IUK4
uniprot id: A0A8M9QL50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

7955:gpx3
gene id: 7955:gpx3
uniprot id: A0A8M1NIR5
names: Similarity
messages: Belongs to the glutathione peroxidase family.

7955:mpv17l2
gene id: 7955:mpv17l2
uniprot id: Q6DGV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Interacts with the large mitochondrial ribosomal subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Required for the assembly and stability of the mitochondrial ribosome (By similarity). Is a positive regulator of mitochondrial protein synthesis (By similarity).

7955:adgrg4a
gene id: 7955:adgrg4a
uniprot id: A0A140LGW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

7955:brd1a
gene id: 7955:brd1a
uniprot id: A0A8M9Q6D7
uniprot id: F1QFR1
names: Subcellular Location Annotation
messages: Nucleus

7955:slc22a18
gene id: 7955:slc22a18
uniprot id: Q32LS0
names: Subcellular Location Annotation
messages: Membrane

7955:glp2r
gene id: 7955:glp2r
uniprot id: A0A8M3B4C0
names: Subcellular Location Annotation
messages: Membrane

7955:pex14
gene id: 7955:pex14
uniprot id: A0A2R8QMZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-14 family.
messages: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
messages: Peroxisome membrane

7955:rpa3
gene id: 7955:rpa3
uniprot id: Q7ZUZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

7955:ap2s1
gene id: 7955:ap2s1
uniprot id: Q6PEJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cell membrane
messages: coated pit

7955:eif2s2
gene id: 7955:eif2s2
uniprot id: Q6NY78
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

7955:prkar2aa
gene id: 7955:prkar2aa
uniprot id: A9C3T0
uniprot id: Q08BH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

7955:hpgd
gene id: 7955:hpgd
uniprot id: A0A8M3AIL6
uniprot id: A0A8M9QCH9
uniprot id: E7F258
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:eya1
gene id: 7955:eya1
uniprot id: A0A8M2B9H5
uniprot id: A0A8M3AP55
uniprot id: A0A8M3AZ17
uniprot id: A0A8M6YVK2
uniprot id: Q6DBY3
uniprot id: Q9W6E8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

7955:v2rl1
gene id: 7955:v2rl1
uniprot id: A8E7K1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:snrnp200
gene id: 7955:snrnp200
uniprot id: B0S754
names: Similarity
messages: Belongs to the helicase family. SKI2 subfamily.

7955:zgc:86598
gene id: 7955:zgc:86598
uniprot id: A0A8M2B6B1
uniprot id: Q6IQV0
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:kif13ba
gene id: 7955:kif13ba
uniprot id: A0A8M2BH26
uniprot id: A0A8M6YTA9
uniprot id: A0A8N7TFU3
uniprot id: X1WFZ0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:nt5dc3
gene id: 7955:nt5dc3
uniprot id: E7FFE8
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

7955:zgc:158773
gene id: 7955:zgc:158773
uniprot id: A2VD46
names: Subcellular Location Annotation
messages: Membrane

7955:cyp2k21
gene id: 7955:cyp2k21
uniprot id: A0A8N7UVB4
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:fam83hb
gene id: 7955:fam83hb
uniprot id: G1K2R9
uniprot id: Q1LVV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM83 family.
messages: May play a role in keratin cytoskeleton disassembly.
messages: cytoskeleton

7955:pgpep1
gene id: 7955:pgpep1
uniprot id: Q504F8
names: Similarity
messages: Belongs to the peptidase C15 family.

7955:traf6
gene id: 7955:traf6
uniprot id: Q6IWL4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TNF receptor-associated factor family. A subfamily.
messages: Cytoplasm
messages: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation.
messages: Homotrimer. Homooligomer.
messages: Lipid droplet
messages: Nucleus
messages: The MATH/TRAF domain binds to receptor cytoplasmic domains.
messages: The coiled coil domain mediates homo- and hetero-oligomerization.
messages: cell cortex

7955:LOC799265
gene id: 7955:LOC799265
uniprot id: E7EXH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

7955:rnft1
gene id: 7955:rnft1
uniprot id: Q6NZ21
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis.
messages: Endoplasmic reticulum membrane

7955:dlc1
gene id: 7955:dlc1
uniprot id: A0A8M6Z677
uniprot id: A0A8M9PK49
uniprot id: E7FBY0
names: Subcellular Location Annotation
messages: Cytoplasm

7955:si:ch211-266i6.3
gene id: 7955:si:ch211-266i6.3
uniprot id: A0A8M9QCL0
uniprot id: E7F392
names: Similarity
messages: Belongs to the CKAP2 family.

7955:ypel2b
gene id: 7955:ypel2b
uniprot id: E7F3A4
names: Similarity
messages: Belongs to the yippee family.

7955:msx2a
gene id: 7955:msx2a
uniprot id: Q4VBK3
names: Subcellular Location Annotation
messages: Nucleus

7955:pcdh2g3
gene id: 7955:pcdh2g3
uniprot id: I6LD70
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

7955:LOC100147904
gene id: 7955:LOC100147904
uniprot id: A0A8M1QQZ4
uniprot id: A0A8M9QCN3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:bmpr2a
gene id: 7955:bmpr2a
uniprot id: A0A8M2BD77
uniprot id: Q288P3
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

7955:arl8bb
gene id: 7955:arl8bb
uniprot id: F1RBH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

7955:slc13a2
gene id: 7955:slc13a2
uniprot id: Q6P3L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

7955:pik3cb
gene id: 7955:pik3cb
uniprot id: E7F251
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

7955:thap1
gene id: 7955:thap1
uniprot id: A0A0R4IRT9
uniprot id: Q1JPT7
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THAP1 family.
messages: Contaminating sequence. Sequence of unknown origin.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes (By similarity).
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: nucleoplasm

7955:paics
gene id: 7955:paics
uniprot id: Q7ZUN6
names: Similarity
names: Subunit
messages: Homooctamer.
messages: In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.
messages: In the N-terminal section; belongs to the SAICAR synthetase family.

7955:fabp2
gene id: 7955:fabp2
uniprot id: A0A8M2BI88
uniprot id: Q8AX65
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

7955:pi4kaa
gene id: 7955:pi4kaa
uniprot id: A0A8M2BJV9
uniprot id: A0A8M3AWF4
uniprot id: Q49GP4
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

7955:mmp11b
gene id: 7955:mmp11b
uniprot id: A0A8N7T826
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

7955:etv4
gene id: 7955:etv4
uniprot id: A0A8M3AY95
uniprot id: A0A8N1TV56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

7955:h2afva
gene id: 7955:h2afva
uniprot id: A0A8M2BCB5
uniprot id: A2BFY9
uniprot id: Q71PD7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-5, Lys-8 and Lys-12 when associated with the 5'-end of active genes.
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AZ1 forms a heterodimer with H2B (By similarity).
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity).

7955:arpc1b
gene id: 7955:arpc1b
uniprot id: Q7T372
names: Function
names: Similarity
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

7955:slc39a8
gene id: 7955:slc39a8
uniprot id: A0A8M3AYZ5
names: Subcellular Location Annotation
messages: Membrane

7955:slc16a3
gene id: 7955:slc16a3
uniprot id: F1Q7T3
uniprot id: Q7ZVM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

7955:mmp28
gene id: 7955:mmp28
uniprot id: A0A2R8RUJ1
uniprot id: A0A8M3AH08
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

7955:timm50
gene id: 7955:timm50
uniprot id: B2GQE9
uniprot id: Q6NWD4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: At 48 hours post-fertilization (hpf), it is highly expressed in the CNS, particularly in the brain tissues. The pattern is the same at 72 hpf.
messages: Belongs to the TIM50 family.
messages: Component of the TIM23 complex at least composed of timm23, timm17 and timm50.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Massive apoptosis in the CNS, probably due to loss of mitochondrial function and increased cytochrome c release.
messages: Mitochondrion inner membrane

7955:odf2a
gene id: 7955:odf2a
uniprot id: E7F186
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF2 family.
messages: centrosome

7955:greb1
gene id: 7955:greb1
uniprot id: F1QAG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GREB1 family.
messages: Membrane

7955:ptpn21
gene id: 7955:ptpn21
uniprot id: A0A286YBL8
uniprot id: F1Q6T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

7955:fxn
gene id: 7955:fxn
uniprot id: A2RRV1
names: Similarity
messages: Belongs to the frataxin family.

7955:neu3.1
gene id: 7955:neu3.1
uniprot id: A0PJS4
uniprot id: I3ITP7
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

7955:caskin1
gene id: 7955:caskin1
uniprot id: A0A8M3AQR6
uniprot id: A0A8M3AQS1
uniprot id: A0A8M3AR14
uniprot id: A0A8M3AR19
uniprot id: A0A8M3AY55
uniprot id: A0A8M3AY61
uniprot id: A0A8M3B8E4
uniprot id: A0A8M3B8E9
uniprot id: A0A8M9Q5E2
names: Subcellular Location Annotation
messages: Cytoplasm

7955:rgn
gene id: 7955:rgn
uniprot id: A0A8M9QFA2
uniprot id: Q6TLF6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMP-30/CGR1 family.
messages: Binds 1 divalent metal cation per subunit. Most active with Zn(2+) and Mn(2+) ions. The physiological cofactor is most likely Ca(2+) or Mg(2+).
messages: Cytoplasm
messages: Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).

7955:pargl
gene id: 7955:pargl
uniprot id: A0A0R4ITH7
names: Similarity
messages: Belongs to the poly(ADP-ribose) glycohydrolase family.

7955:whamm
gene id: 7955:whamm
uniprot id: A0A8M9PQE9
names: Subcellular Location Annotation
messages: Membrane

7955:crygmx
gene id: 7955:crygmx
uniprot id: Q5XTN0
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:cryba1a
gene id: 7955:cryba1a
uniprot id: Q6DH14
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:si:ch211-113a14.7
gene id: 7955:si:ch211-113a14.7
uniprot id: Q561S9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:pbrm1
gene id: 7955:pbrm1
uniprot id: A0A8M3B6P7
uniprot id: A0A8M9QLS6
uniprot id: E7F8D8
names: Subcellular Location Annotation
messages: Nucleus

7955:senp8
gene id: 7955:senp8
uniprot id: Q08CI6
names: Similarity
messages: Belongs to the peptidase C48 family.

7955:vax1
gene id: 7955:vax1
uniprot id: A0A0R4I9B5
uniprot id: Q801E0
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the EMX homeobox family.
messages: Expressed in the anterior neural keel and later in the preoptic area and optic stalk.
messages: First detected in the anterior neural keel at 7 somites. By 12 somites, expression is more robust in the medial forebrain and forming eyes. By 16 somites, expression remains within the optic stalk and is predominantly restricted to tissue ventral to the optic stalk and ventral preoptic area. In addition to optic stalk and ventral preoptic area, weakly expressed in the ventral retina near the choroid fissure region by 24 hpf (hours post-fertilization). At 48 hpf, expression remains prominent in the ventral preoptic area but is much reduced in the choroid fissure and optic stalk.
messages: Nucleus
messages: Transcription factor that is required for closure of the choroid fissure and together with Vax2 is required for optic nerve differentiation and to limit retinal development to the optic cup.

7955:kif7
gene id: 7955:kif7
uniprot id: F1QH25
uniprot id: Q58G59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts downstream of smo as an intracellular repressor of hedgehog signaling pathway, mainly through the suppression of gli1 activity. This negative regulatory effect is enhanced in conjunction with the suppressor of fused (sufu) protein. Positively regulates gli2a activity by promoting its dissociation from sufu. Involved in the regulation of microtubular dynamics.
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF27 subfamily.
messages: Binds microtubules. Interacts with gli1 and sufu.
messages: cilium
messages: cytoskeleton

7955:elp5
gene id: 7955:elp5
uniprot id: A1A5V9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELP5 family.
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity).
messages: Component of the elongator complex.
messages: Cytoplasm
messages: Nucleus
messages: The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification.

7955:dhx58
gene id: 7955:dhx58
uniprot id: A0A8M9PDC5
uniprot id: F1QUY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

7955:cx43
gene id: 7955:cx43
uniprot id: O57474
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A connexon is composed of a hexamer of connexins. Interacts with TMEM65.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Expressed both maternally and zygotically. Zygotic expression is initiated before gastrulation and persists through to day 5 of development. Levels increase in late somitogenesis, and late embryonic and early larval stages. Embryonic expression is observed in many developing tissues and organs, including the notochord and brain, and heart and vasculature. Detected throughout the lens at 24 hours post-fertilization (hpf), but by 3-4 days development, restricted to the lateral epithelium and differentiating cells in the equatorial region.
messages: Expressed in adult ovary, heart, lens and liver. In growing caudal fins, expressed in cells flanking the germinal region of newly growing segments and in osteoblasts at segment boundaries.
messages: Morpholino knockdown of the protein results in heart folding defects, reduced hematopoiesis and small eyes.
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Plays an essential role in gap junction communication in the ventricles (By similarity).
messages: Plays a role in regulation of fin bone size and growth.
messages: gap junction

7955:gfra4a
gene id: 7955:gfra4a
uniprot id: B1H1I2
names: Similarity
messages: Belongs to the GDNFR family.

7955:wls
gene id: 7955:wls
uniprot id: F2Z4U3
uniprot id: Q7T357
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the wntless family.
messages: Golgi apparatus membrane
messages: Membrane

7955:LOC110438104
gene id: 7955:LOC110438104
uniprot id: A0A8M9PFW5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:alg10
gene id: 7955:alg10
uniprot id: E7FEB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Membrane

7955:pisd
gene id: 7955:pisd
uniprot id: A0A8M6YY80
uniprot id: A0A8M9QDX6
uniprot id: A1A5T2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

7955:focad
gene id: 7955:focad
uniprot id: E7FGT5
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Gene knockdown results in decreased overall survival and growth retardation. Mutant fishes have pathological liver features, including swollen hepatocytes, steatosis, fibrosis, and hepatocyte apoptosis.
messages: Required for the maintenance of SKIC2 and SKIC3 proteostatic levels in the liver. May be involved in the regulation of RNA degradation by the exosome complex.
messages: cytosol
messages: focal adhesion

7955:ddx27
gene id: 7955:ddx27
uniprot id: Q6DRN0
names: Similarity
messages: Belongs to the DEAD box helicase family.

7955:LOC796202
gene id: 7955:LOC796202
uniprot id: A0A8M9P965
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:hesx1
gene id: 7955:hesx1
uniprot id: P79738
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANF homeobox family.
messages: Nucleus

7955:pglyrp2
gene id: 7955:pglyrp2
uniprot id: A5GZR3
uniprot id: Q1W1Y3
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

7955:LOC101886116
gene id: 7955:LOC101886116
uniprot id: A0A8M9PYA5
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

7955:si:ch211-106j24.1
gene id: 7955:si:ch211-106j24.1
uniprot id: E7F123
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

7955:creb5a
gene id: 7955:creb5a
uniprot id: A0A0R4IL04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

7955:ch25hl2
gene id: 7955:ch25hl2
uniprot id: A8WGT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family.
messages: Endoplasmic reticulum membrane
messages: May catalyze the formation of 25-hydroxycholesterol from cholesterol.

7955:LOC100331050
gene id: 7955:LOC100331050
uniprot id: A0A8M2B8Q3
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:acvr2b
gene id: 7955:acvr2b
uniprot id: Q9YGU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

7955:anxa3b
gene id: 7955:anxa3b
uniprot id: A8E5E5
uniprot id: Q5U369
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

7955:rxfp3.3a1
gene id: 7955:rxfp3.3a1
uniprot id: F1QQH4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:flt4
gene id: 7955:flt4
uniprot id: A0A0R4IFS9
uniprot id: A0A2R8QSE0
uniprot id: A0A8M3AZL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

7955:rnf25
gene id: 7955:rnf25
uniprot id: Q7SXJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF25 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (By similarity). May also acts as a positive regulator of the Wnt signaling (PubMed:27007149).

7955:dldh
gene id: 7955:dldh
uniprot id: Q803L1
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.
messages: acrosome
messages: flagellum

7955:kif26ab
gene id: 7955:kif26ab
uniprot id: A0A8M2B5F7
uniprot id: A0A8M2B5I5
uniprot id: A0A8M2B5W9
uniprot id: A0A8M2B5X7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:znf532
gene id: 7955:znf532
uniprot id: A0A8M2B806
uniprot id: A0A8M3AM08
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

7955:znf408
gene id: 7955:znf408
uniprot id: E7FAN3
names: Subcellular Location Annotation
messages: Nucleus

7955:tnfrsf21
gene id: 7955:tnfrsf21
uniprot id: A5D8S6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:v2rx3
gene id: 7955:v2rx3
uniprot id: A0A8M3AJP9
uniprot id: A0A8M3AKI9
uniprot id: A0A8M3AS25
uniprot id: A0A8M3AUZ8
uniprot id: A0A8M3B311
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:nrd1a
gene id: 7955:nrd1a
uniprot id: B0S6B9
names: Similarity
messages: Belongs to the peptidase M16 family.

7955:kif20ba
gene id: 7955:kif20ba
uniprot id: A0A8M1RFH9
uniprot id: E7FAN6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:tubb2b
gene id: 7955:tubb2b
uniprot id: A0A8M1N7Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

7955:dlg3
gene id: 7955:dlg3
uniprot id: A0A8M3AGS5
uniprot id: A0A8M3AS60
uniprot id: A0A8M3B0G6
uniprot id: A0A8M9PBS2
uniprot id: A0A8M9PZS5
uniprot id: A0A8M9PZT0
uniprot id: A0A8M9Q1J7
uniprot id: A0A8M9Q5B2
uniprot id: A0A8M9QBJ7
uniprot id: A0A8M9QBK2
uniprot id: A0A8M9QGS1
uniprot id: A0A8M9QGS9
uniprot id: A0A8M9QL03
uniprot id: A0A8M9QL07
uniprot id: A0A8M9QPH5
uniprot id: A0A8M9QPI0
uniprot id: A0A8M9QPI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Membrane

7955:elovl6l
gene id: 7955:elovl6l
uniprot id: Q802X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

7955:ciao1
gene id: 7955:ciao1
uniprot id: Q6P0D9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat CIA1 family.
messages: Component of the CIA complex.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins.

7955:ppip5k1a
gene id: 7955:ppip5k1a
uniprot id: A0A8M9PQ41
uniprot id: A0A8M9Q2S4
uniprot id: A0A8M9Q8X0
uniprot id: A0A8M9QD12
uniprot id: A0A8M9QI11
uniprot id: A0A8N7UVM3
uniprot id: E7FFN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

7955:minos1
gene id: 7955:minos1
uniprot id: Q0P405
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

7955:slco1f1
gene id: 7955:slco1f1
uniprot id: A0A0R4IBD9
uniprot id: A0A8M6YXX6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:ube2g2
gene id: 7955:ube2g2
uniprot id: Q567F7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7955:aebp1
gene id: 7955:aebp1
uniprot id: E7F829
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

7955:slc30a4
gene id: 7955:slc30a4
uniprot id: A0A8M2BKW4
uniprot id: A0A8M9PM11
uniprot id: Q6PFS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

7955:cers6
gene id: 7955:cers6
uniprot id: F1QPF3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

7955:atg4c
gene id: 7955:atg4c
uniprot id: A0A8M9PM06
uniprot id: Q6IQ96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

7955:pomt2
gene id: 7955:pomt2
uniprot id: F1Q8R9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 39 family.
messages: Detected throughout development (PubMed:18632251, PubMed:20466645). Highest expression levels are found at 0 hours post-fertilization (hpf), probably due to perdurance of maternal transcripts (PubMed:20466645). Expression levels remain high at 6 hpf and decrease rapidly by 12 hpf, followed by a second moderate peak in expression at 24 hpf (PubMed:20466645). Ubiquitously expressed during early stages of development (PubMed:18632251, PubMed:20466645). At 16-24 hpf, mainly found in eye, brain and somites (PubMed:18632251, PubMed:20466645). At 30 hpf, has strongest expression in forebrain, cerebellum and hindbrain (PubMed:18632251).
messages: Endoplasmic reticulum membrane
messages: Morpholino knockdown of the protein results in developmental delays at 18 hours post fertilization (hpf). At 48-72 hpf the tail is abnormally twisted, and pericardium formation and eye pigmentation are also abnormal. Swim bladders are incompletely formed. Glycosylation of alpha-dystroglycan (dag1) is severely reduced.
messages: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient.
messages: Widely expressed. Has particularly strong expression in ovary, testis, liver, brain, muscle, heart and eye.

7955:rbm24a
gene id: 7955:rbm24a
uniprot id: Q76LC6
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Expressed in the embryo from 2 to 72 hours post-fertilization (hpf) (PubMed:22345307). Expressed in the embryonic heart and somites at 14, 20 and 24 hpf (PubMed:22345307). Expressed in myocardial progenitors from 18 to 24 hpf (PubMed:22345307). Expressed in the otic vesicle at 14 hpf (PubMed:22345307).
messages: Morpholino knockdown of the protein leads to death at 6 days post-fertilization (dpf) due to heart growth defects and absence of blood circulation, despite the presence of a beating heart (PubMed:22345307). Show reduced heart contractility from 30 hours post-fertilization (hpf), onwards (PubMed:22345307). Display defects in sarcomere organization from 33 hpf, onwards (PubMed:22345307). Show altered expression of key genes necessary for sarcomere formation (PubMed:22345307).
messages: Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation. Plays a major role in pre-mRNA alternative splicing regulation. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation. Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing. Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes. Plays a role in the regulation of mRNA stability and mRNA translation to which it is bound. Involved in myogenic differentiation by regulating myog levels. Binds to a huge amount of mRNAs (By similarity). Required for embryonic heart development, sarcomer and M-band formation in striated muscles (PubMed:22345307).
messages: Nucleus
messages: The RRM domain is necessary for mRNA stability and mRNA translation regulation.

7955:mchr1b
gene id: 7955:mchr1b
uniprot id: A0A8N7TF54
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with NCDN.
messages: Membrane

7955:fam131bb
gene id: 7955:fam131bb
uniprot id: A0A8M3AQH3
uniprot id: A0A8M3ATB3
uniprot id: A0A8M9NZM9
uniprot id: E7FE88
names: Similarity
messages: Belongs to the FAM131 family.

7955:LOC110437731
gene id: 7955:LOC110437731
uniprot id: A0A8M1RIT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

7955:cox7c
gene id: 7955:cox7c
uniprot id: Q6PBP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

7955:nipa2
gene id: 7955:nipa2
uniprot id: A0A8M2BDB1
uniprot id: Q6P694
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

7955:atrnl1a
gene id: 7955:atrnl1a
uniprot id: F1Q4X2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:loxl5a
gene id: 7955:loxl5a
uniprot id: A0A8M9PJL8
uniprot id: A6MH34
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

7955:tuba8l2
gene id: 7955:tuba8l2
uniprot id: Q6PC95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

7955:klhl24a
gene id: 7955:klhl24a
uniprot id: Q08BL9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Expressed in the cardiac cone, especially in the central region harbouring ventricular myocytes by 22 hours post-fertilization (hpf). At 72 hpf, when the heart is an S-shaped loop, klhl24a transcripts are detected in the ventricle and at a lower level in the atrium.
messages: Forms homodimers (By similarity). Component of the BCR(KLHL24) E3 ubiquitin ligase complex (By similarity).
messages: Morpholino-injected embryos show heart function anomalies detectable after 48 hpf. Heart defects initially manifest as pericardial edema, changed heart rate and reduced blood circulation, and later result in ventricular failure and blood circulation block.
messages: Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity (By similarity). Reduces kainate receptor-mediated currents in brain neurons, most probably by modulating channel properties (By similarity). It is required for proper heart development (PubMed:30715372).
messages: Perikaryon
messages: adherens junction
messages: axon
messages: desmosome

7955:slc13a5a
gene id: 7955:slc13a5a
uniprot id: A0A2R8QQN0
uniprot id: A0A8M1NSQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

7955:abca1b
gene id: 7955:abca1b
uniprot id: E7F2Y6
uniprot id: F8W2X9
names: Subcellular Location Annotation
messages: Membrane

7955:sh3bp5la
gene id: 7955:sh3bp5la
uniprot id: Q6PFU6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

7955:si:dkey-261m9.12
gene id: 7955:si:dkey-261m9.12
uniprot id: E7F5A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

7955:plpp4
gene id: 7955:plpp4
uniprot id: A0A8M1RRC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

7955:mtmr6
gene id: 7955:mtmr6
uniprot id: Q803S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

7955:smad6b
gene id: 7955:smad6b
uniprot id: Q1L8Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

7955:tbx15
gene id: 7955:tbx15
uniprot id: A0A2R8QEJ0
uniprot id: A0A8M9QAK7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7955:pde8a
gene id: 7955:pde8a
uniprot id: A1L1W3
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

7955:LOC101883330
gene id: 7955:LOC101883330
uniprot id: A0A8M3AQB6
names: Similarity
messages: Belongs to the HARBI1 family.

7955:fam129ab
gene id: 7955:fam129ab
uniprot id: E7FC82
names: Similarity
messages: Belongs to the Niban family.

7955:nt5c2b
gene id: 7955:nt5c2b
uniprot id: A0A8M9PH62
uniprot id: A0A8M9PUC7
uniprot id: F1QAK5
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

7955:fzd6
gene id: 7955:fzd6
uniprot id: Q6P0Y7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:LOC110438013
gene id: 7955:LOC110438013
uniprot id: A0A8M9P8P8
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

7955:afap1l1a
gene id: 7955:afap1l1a
uniprot id: Q4V8Y7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in podosome and invadosome formation.
messages: invadopodium
messages: podosome
messages: stress fiber

7955:fgd1
gene id: 7955:fgd1
uniprot id: A0A8M6Z0K6
uniprot id: A0A8M6Z282
uniprot id: A0A8M6Z859
uniprot id: A0A8N7T6X2
names: Subcellular Location Annotation
messages: cytoskeleton

7955:ambp
gene id: 7955:ambp
uniprot id: A7E2Q2
names: Similarity
names: Subcellular Location Annotation
messages: In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

7955:bnip1b
gene id: 7955:bnip1b
uniprot id: A0A0R4IG59
names: Subcellular Location Annotation
messages: Membrane

7955:ppp2r2ab
gene id: 7955:ppp2r2ab
uniprot id: A2BG80
uniprot id: Q6PGU9
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

7955:kcnma1a
gene id: 7955:kcnma1a
uniprot id: A0A2R8QRZ7
uniprot id: A0A8M2B2Q5
uniprot id: A0A8M2B2Q8
uniprot id: A0A8M2B2S7
uniprot id: A0A8M2B2T1
uniprot id: A0A8M2B2Z4
uniprot id: A0A8M2B303
uniprot id: A0A8M2B3E8
uniprot id: A0A8M2B3F4
uniprot id: A0A8M2B3J8
uniprot id: A0A8M2B3K4
uniprot id: A0A8M3AYZ7
uniprot id: A0A8M3AZ02
uniprot id: A0A8M3AZ19
uniprot id: A0A8M3AZ25
uniprot id: A0A8M3B560
uniprot id: A0A8M3B563
uniprot id: A0A8M3B7Y4
uniprot id: A0A8M3B7Y9
uniprot id: A0A8M3BEL0
uniprot id: A0A8M6Z1R0
uniprot id: A0A8M6Z2C3
uniprot id: A0A8M6Z3V4
uniprot id: A0A8M6Z968
uniprot id: A0A8M6Z9L7
uniprot id: A0A8M6Z9M0
uniprot id: A0A8M9PY17
uniprot id: A0A8M9PY23
uniprot id: A0A8M9Q9V0
uniprot id: A0A8M9QFI6
uniprot id: A0A8M9QJS7
uniprot id: A0A8M9QNH1
uniprot id: A0A8M9QNH5
uniprot id: B7ZC96
uniprot id: F1QYL4
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
messages: Cell membrane
messages: Expressed during larval stages.
messages: Homotetramer; which constitutes the calcium-activated potassium channel.
messages: Membrane
messages: Morpholino knockdown causes circling phenotype characteristic of hearing and balance deficits (PubMed:24803460). Causes a dose-dependent increase in auditory threshold in hair cells; simultaneous knockdown of kcnma1b does not significantly increase auditory threshold (PubMed:24803460).
messages: Palmitoylated.
messages: Phosphorylated.
messages: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+) (PubMed:22139424). It is also activated by the concentration of cytosolic Mg(2+) (By similarity). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane (By similarity). It therefore contributes to repolarization of the membrane potential (By similarity). Involved in determining peripheral auditory sensitivity (PubMed:24803460).
messages: The calcium bowl constitutes one of the Ca(2+) sensors and probably acts as a Ca(2+)-binding site (PubMed:22139424). There are however other Ca(2+) sensor regions required for activation of the channel (PubMed:22139424).

7955:igf2bp1
gene id: 7955:igf2bp1
uniprot id: A0A0B4J1A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: Nucleus
messages: filopodium
messages: growth cone
messages: lamellipodium
messages: perinuclear region

7955:LOC553386
gene id: 7955:LOC553386
uniprot id: A0A8M2BEQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

7955:ptger2a
gene id: 7955:ptger2a
uniprot id: Q6PFT8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:si:ch211-140l13.3
gene id: 7955:si:ch211-140l13.3
uniprot id: A0A8M6YUD2
names: Similarity
messages: Belongs to the TCP10 family.

7955:etv2
gene id: 7955:etv2
uniprot id: A0A2R8Q5A3
uniprot id: Q30JB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

7955:tuba2
gene id: 7955:tuba2
uniprot id: Q6P972
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

7955:LOC100001344
gene id: 7955:LOC100001344
uniprot id: A0A8M9QDF0
uniprot id: A5WUM2
names: Subcellular Location Annotation
messages: Nucleus

7955:msh4
gene id: 7955:msh4
uniprot id: A0A8M3AK30
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.

7955:lhcgr
gene id: 7955:lhcgr
uniprot id: A0A8M9QNC1
uniprot id: Q6TCF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
messages: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.

7955:prph
gene id: 7955:prph
uniprot id: A0A8M6Z374
uniprot id: Q502Q7
names: Similarity
messages: Belongs to the intermediate filament family.

7955:zar1
gene id: 7955:zar1
uniprot id: Q561Z6
names: Similarity
messages: Belongs to the ZAR1 family.

7955:ccdc53
gene id: 7955:ccdc53
uniprot id: Q5RGJ6
names: Similarity
names: Subunit
messages: Belongs to the CCDC53 family.
messages: Component of the WASH complex.

7955:LOC100007727
gene id: 7955:LOC100007727
uniprot id: A0A8M9Q5N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

7955:setdb1a
gene id: 7955:setdb1a
uniprot id: Q1L8U8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Chromosome
messages: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Plays a role in promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (By similarity).
messages: In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
messages: Nucleus

7955:mpp5b
gene id: 7955:mpp5b
uniprot id: A0A8M3AL41
uniprot id: A0A8M3B4D4
uniprot id: D3X469
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: tight junction

7955:tgm2a
gene id: 7955:tgm2a
uniprot id: Q66L63
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

7955:cacna1hb
gene id: 7955:cacna1hb
uniprot id: A0A8M9Q7Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.

7955:kcnb2
gene id: 7955:kcnb2
uniprot id: A0A8M2BAM8
names: Subcellular Location Annotation
messages: Membrane
messages: Perikaryon
messages: dendrite

7955:dph2
gene id: 7955:dph2
uniprot id: A4QN59
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster facilitates the reduction of the catalytic iron-sulfur cluster in the dph1 subunit.
messages: Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of dph1, dph2, dph3 and a NADH-dependent reductase.
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (By similarity). Dph1 and dph2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising dph3 and a NADH-dependent reductase (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the dph1 subunit (By similarity).

7955:igf2b
gene id: 7955:igf2b
uniprot id: Q8JIE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

7955:atg4da
gene id: 7955:atg4da
uniprot id: A0A8M9Q0Z1
uniprot id: R4GER2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (By similarity). The protease activity is required for proteolytic activation of ATG8 family proteins to reveal a C-terminal glycine (By similarity). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (By similarity). In addition to the protease activity, also mediates delipidation of ATG8 family proteins. Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy (By similarity). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, by catalyzing delipidation of ATG8 proteins conjugated to phosphatidylserine (PS) (By similarity). ATG4D plays a role in the autophagy-mediated neuronal homeostasis in the central nervous system (PubMed:25875846).
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm
messages: Morpholino knockdown of the protein results in neurodegeneration in the central nervous system (CNS) (PubMed:25875846). Neurodegeneration is characterized by severe visible malformations in the developing CNS in regions that correspond to the midbrain-hindbrain boundary, the cerebellum and the hindbrain region (PubMed:25875846).

7955:vps28
gene id: 7955:vps28
uniprot id: Q6PH25
names: Function
names: Similarity
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.

7955:lpcat2
gene id: 7955:lpcat2
uniprot id: F1Q8S6
uniprot id: Q502J0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Exhibits both acyltransferase and acetyltransferase activities (By similarity). Activity is calcium-dependent (By similarity). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (By similarity). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (By similarity).
messages: Golgi apparatus membrane
messages: Lipid droplet
messages: The HXXXXD motif is essential for acyltransferase activity.

7955:nedd9
gene id: 7955:nedd9
uniprot id: Q08BB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

7955:polr2l
gene id: 7955:polr2l
uniprot id: A5D6S6
names: Similarity
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.

7955:cfhl4
gene id: 7955:cfhl4
uniprot id: A0A8M3AMD6
uniprot id: E2FHP8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:atxn1b
gene id: 7955:atxn1b
uniprot id: E7F6Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

7955:notch2
gene id: 7955:notch2
uniprot id: F1RCH4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

7955:gadd45ga
gene id: 7955:gadd45ga
uniprot id: Q6P021
names: Similarity
messages: Belongs to the GADD45 family.

7955:cx28.1
gene id: 7955:cx28.1
uniprot id: Q5TYN8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:ap5m1
gene id: 7955:ap5m1
uniprot id: A0A8M2B5U6
uniprot id: Q502J2
names: Subcellular Location Annotation
names: Subunit
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.

7955:mif4gda
gene id: 7955:mif4gda
uniprot id: B0UXU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MIF4GD family.
messages: Cytoplasm
messages: Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation (By similarity).
messages: Interacts with eif4g1, eif4g2 and slbp; probably tethered by SLBP to the 3'-end of mRNAs ending with the histone stem-loop, it also interacts with eif4g1 which is bound to their 5'-end.
messages: Nucleus

7955:or103-1
gene id: 7955:or103-1
uniprot id: Q9PRJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:hcar1-2
gene id: 7955:hcar1-2
uniprot id: C6EVZ8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:gpr37l1b
gene id: 7955:gpr37l1b
uniprot id: F1R116
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:dcp2
gene id: 7955:dcp2
uniprot id: Q803B9
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

7955:ddr2a
gene id: 7955:ddr2a
uniprot id: A0A8M2BDP6
uniprot id: A0A8M2BDR2
uniprot id: E7FFT8
names: Subcellular Location Annotation
messages: Membrane

7955:hsp90ab1
gene id: 7955:hsp90ab1
uniprot id: O57521
names: Activity Regulation
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the heat shock protein 90 family.
messages: By heat shock during early embryogenesis.
messages: Cytoplasm
messages: Detected throughout the embryo and in low levels in the musculature. Expressed predominantly in the developing brain, tail bud and cells surrounding the posterior margin of the yolk tube.
messages: Dynein axonemal particle
messages: Expressed throughout embryonic development.
messages: In the resting state, through the dimerization of its C-terminal domain, HSP90 forms a homodimer which is defined as the open conformation. Upon ATP-binding, the N-terminal domain undergoes significant conformational changes and comes in contact to form an active closed conformation. After HSP90 finishes its chaperoning tasks of assisting the proper folding, stabilization and activation of client proteins under the active state, ATP molecule is hydrolyzed to ADP which then dissociates from HSP90 and directs the protein back to the resting state.
messages: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (By similarity). Not required for myofibril formation in skeletal muscles (PubMed:10364427, PubMed:17586488).
messages: Monomer. Homodimer (By similarity). Interacts with unc45b (PubMed:17586488).
messages: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.

7955:LOC100329560
gene id: 7955:LOC100329560
uniprot id: A7MCA7
uniprot id: Q5BJA5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-111 promotes monoubiquitination of Lys-119. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-119 by the BRE1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: Phosphorylated during apoptosis; which facilitates apoptotic chromatin condensation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:lingo1b
gene id: 7955:lingo1b
uniprot id: Q66HV9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.

7955:slc10a4
gene id: 7955:slc10a4
uniprot id: A0A8M1N9C8
uniprot id: A0A8M1PA55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

7955:cmpk2
gene id: 7955:cmpk2
uniprot id: A0A8N7T8K9
names: Similarity
messages: Belongs to the thymidylate kinase family.

7955:ipo9
gene id: 7955:ipo9
uniprot id: A0A8M2BGJ6
uniprot id: Q6PCR2
names: Subcellular Location Annotation
messages: Cytoplasm

7955:sdc2
gene id: 7955:sdc2
uniprot id: Q66I66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

7955:pik3cg
gene id: 7955:pik3cg
uniprot id: A0A8M9PH51
uniprot id: A0A8M9Q5U7
uniprot id: Q6NTI2
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

7955:LOC100000713
gene id: 7955:LOC100000713
uniprot id: A0A8M1PUI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tango11 family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.

7955:pbx1b
gene id: 7955:pbx1b
uniprot id: A0A8M9PM87
uniprot id: A0A8M9QAG1
uniprot id: A0A8M9QFI5
uniprot id: A2VD48
uniprot id: F1QSY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

7955:manf
gene id: 7955:manf
uniprot id: Q08CA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

7955:zgc:172282
gene id: 7955:zgc:172282
uniprot id: A8WGA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRFN family.
messages: May be involved in the regulation of excitatory synapses.
messages: Membrane
messages: Synapse

7955:LOC100333863
gene id: 7955:LOC100333863
uniprot id: A0A8M2BGY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

7955:lrrc8da
gene id: 7955:lrrc8da
uniprot id: A2BIH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

7955:si:dkeyp-82a1.6
gene id: 7955:si:dkeyp-82a1.6
uniprot id: E9QJ57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOR1AIP family.
messages: Membrane

7955:LOC101883850
gene id: 7955:LOC101883850
uniprot id: A0A8M2BJ08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

7955:dcaf11
gene id: 7955:dcaf11
uniprot id: Q499B0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat LEC14B family.
messages: Interacts with DDB1 and CUL4A.
messages: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

7955:hnrnpa1b
gene id: 7955:hnrnpa1b
uniprot id: Q803K3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7955:selp
gene id: 7955:selp
uniprot id: E5DV48
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:dvl3a
gene id: 7955:dvl3a
uniprot id: B8JMI2
names: Similarity
messages: Belongs to the DSH family.

7955:tgfb2l
gene id: 7955:tgfb2l
uniprot id: A0A8M9QGK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
messages: extracellular matrix

7955:ca15a
gene id: 7955:ca15a
uniprot id: A2VD39
uniprot id: F1Q816
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

7955:echdc1
gene id: 7955:echdc1
uniprot id: A0A8M1P9L1
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

7955:pgfb
gene id: 7955:pgfb
uniprot id: X1WBL7
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

7955:taf4a
gene id: 7955:taf4a
uniprot id: A0A8M1QUY2
uniprot id: E7FBZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF4 family.
messages: Nucleus

7955:mylipb
gene id: 7955:mylipb
uniprot id: Q05AK5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC). Regulates cell movements during gastrulation by acting downstream of fz7 to antagonize the frizzled-signaling pathway (By similarity).
messages: Interacts with anxa5.
messages: cytosol

7955:taar12h
gene id: 7955:taar12h
uniprot id: Q5QNN8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:psmd9
gene id: 7955:psmd9
uniprot id: A0A8M2BGF5
uniprot id: F1R7L1
uniprot id: Q6DH53
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

7955:aldh1l2
gene id: 7955:aldh1l2
uniprot id: A0A8M1RK21
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.

7955:tmem231
gene id: 7955:tmem231
uniprot id: Q7T316
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM231 family.
messages: Part of the tectonic-like complex (also named B9 complex).
messages: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).
messages: cilium membrane

7955:ret
gene id: 7955:ret
uniprot id: A8E7C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.

7955:opa1
gene id: 7955:opa1
uniprot id: A0A8M6Z7B4
uniprot id: A0A8M9PM18
uniprot id: A0A8M9PZN8
uniprot id: A0A8M9Q626
uniprot id: A0A8M9QFC3
uniprot id: A0A8M9QFC7
uniprot id: Q5U3A7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission. Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (By similarity). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity).
messages: Inactive form produced by cleavage at S1 position by oma1 following stress conditions that induce loss of mitochondrial membrane potential, leading to negative regulation of mitochondrial fusion.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: Mitochondrion membrane
messages: Oligomeric complex consisting of membrane-bound and soluble forms of OPA1. Binds PARL (By similarity).
messages: PARL-dependent proteolytic processing releases an antiapoptotic soluble form not required for mitochondrial fusion. Cleaved by oma1 at position S1 following stress conditions.
messages: Proteolytic processing produces an antiapoptotic soluble form Cleaved by oma1 at position S1 following stress conditions.

7955:ebag9
gene id: 7955:ebag9
uniprot id: Q7ZWA8
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.

7955:lgi1a
gene id: 7955:lgi1a
uniprot id: F6NUE1
uniprot id: Q2HPG2
names: Subcellular Location Annotation
messages: Secreted

7955:trim67
gene id: 7955:trim67
uniprot id: A0A8M1RRQ3
uniprot id: A0A8M3AKM3
uniprot id: A0A8M3B3X4
uniprot id: A0A8M9P2W2
uniprot id: A0A8M9PPT3
uniprot id: A0A8M9PT68
names: Subcellular Location Annotation
messages: cytoskeleton

7955:si:ch211-274f20.2
gene id: 7955:si:ch211-274f20.2
uniprot id: A0A8M1PSV3
names: Similarity
messages: Belongs to the calreticulin family.

7955:v2rc1
gene id: 7955:v2rc1
uniprot id: A0A8M1PS22
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:si:dkey-78l4.14
gene id: 7955:si:dkey-78l4.14
uniprot id: Q1LUK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic13 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MIC10 into the MICOS complex.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

7955:zgc:77041
gene id: 7955:zgc:77041
uniprot id: Q6NYP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.

7955:uqcc1
gene id: 7955:uqcc1
uniprot id: Q08CE4
names: Similarity
messages: Belongs to the CBP3 family.

7955:loxl3a
gene id: 7955:loxl3a
uniprot id: A0A5H1ZRI5
uniprot id: F1RD85
names: Caution
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: No visible phenotype.
messages: Nucleus
messages: Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins. Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin. Can mediate oxidation of lysine residues that are acetylated. Also able to catalyze deacetylation of lysine residues (By similarity).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: Weakly expressed at 30 hours post fertilization (hpf) in the ventral head mesenchyme, but not spatially restricted after this time-point.
messages: extracellular space

7955:zgc:165461
gene id: 7955:zgc:165461
uniprot id: A0A8M9PPG4
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

7955:zgc:110319
gene id: 7955:zgc:110319
uniprot id: B8A6A3
uniprot id: Q6P002
names: Similarity
messages: Belongs to the NifU family.

7955:ugt1b1
gene id: 7955:ugt1b1
uniprot id: D3XD60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7955:LOC101886255
gene id: 7955:LOC101886255
uniprot id: A0A8M2BID2
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

7955:zgc:103601
gene id: 7955:zgc:103601
uniprot id: Q5XJ69
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

7955:arhgef12a
gene id: 7955:arhgef12a
uniprot id: A0A2R8QD00
uniprot id: A0A8M3B155
uniprot id: E7FDV8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

7955:gabrr2a
gene id: 7955:gabrr2a
uniprot id: F1QX34
uniprot id: Q0P445
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:tufm
gene id: 7955:tufm
uniprot id: Q5BJ17
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

7955:apool
gene id: 7955:apool
uniprot id: Q58EI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

7955:zmp:0000000634
gene id: 7955:zmp:0000000634
uniprot id: E7EYU7
names: Similarity
messages: Belongs to the HARBI1 family.

7955:slc39a1
gene id: 7955:slc39a1
uniprot id: P59889
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space.
messages: Ubiquitous. Highest levels in ovary, high levels in heart, eye, kidney and brain, moderate levels in intestine and low levels in gill and skin.

7955:jag2b
gene id: 7955:jag2b
uniprot id: Q5TZK7
uniprot id: Q90Y56
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

7955:il10
gene id: 7955:il10
uniprot id: Q5EFQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

7955:tmem47
gene id: 7955:tmem47
uniprot id: Q1LY05
uniprot id: Q6PFT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane
messages: Regulates cell junction organization in epithelial cells.
messages: adherens junction

7955:slc6a16a
gene id: 7955:slc6a16a
uniprot id: A0A8M9PD65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:grb2a
gene id: 7955:grb2a
uniprot id: Q5RKN6
names: Subcellular Location Annotation
messages: Endosome
messages: Golgi apparatus
messages: Nucleus

7955:tmc4
gene id: 7955:tmc4
uniprot id: E7F4Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

7955:LOC110439949
gene id: 7955:LOC110439949
uniprot id: A0A8M9QI29
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:spaw
gene id: 7955:spaw
uniprot id: Q7ZZT5
names: Similarity
messages: Belongs to the TGF-beta family.

7955:galcb
gene id: 7955:galcb
uniprot id: Q7ZUD5
names: Similarity
messages: Belongs to the glycosyl hydrolase 59 family.

7955:zgc:103681
gene id: 7955:zgc:103681
uniprot id: A0A8M9Q0B0
uniprot id: Q5XJ49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Membrane
messages: Nucleus inner membrane

7955:si:ch1073-450f2.1
gene id: 7955:si:ch1073-450f2.1
uniprot id: A0A8M9PAP9
names: Subcellular Location Annotation
messages: Postsynaptic density

7955:arrb2a
gene id: 7955:arrb2a
uniprot id: A0A286YBG8
uniprot id: Q6PFK2
names: Similarity
messages: Belongs to the arrestin family.

7955:trap1
gene id: 7955:trap1
uniprot id: A8WFV1
names: Similarity
messages: Belongs to the heat shock protein 90 family.

7955:sptb
gene id: 7955:sptb
uniprot id: A0A8M2B5B6
uniprot id: F1QQE5
uniprot id: Q9DGM6
names: Similarity
messages: Belongs to the spectrin family.

7955:or131-2
gene id: 7955:or131-2
uniprot id: B3DH96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer. Monomer.
messages: Probable olfactory receptor.

7955:ppifa
gene id: 7955:ppifa
uniprot id: Q66ID2
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

7955:mhc1zea
gene id: 7955:mhc1zea
uniprot id: A0A8M2BIB4
uniprot id: A0A8M6YZS6
uniprot id: A8E7F2
uniprot id: Q7YP14
names: Similarity
messages: Belongs to the MHC class I family.

7955:cacng7b
gene id: 7955:cacng7b
uniprot id: A0A2R8QBC8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2.

7955:ltbp3
gene id: 7955:ltbp3
uniprot id: A0A8M2BCL4
uniprot id: A0A8M2BCQ0
uniprot id: F1QFX6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

7955:sod1
gene id: 7955:sod1
uniprot id: B2GRH9
uniprot id: O73872
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homodimer.
messages: Nucleus

7955:dock3
gene id: 7955:dock3
uniprot id: A0A8M3AMH0
uniprot id: A0A8M3AN91
uniprot id: A0A8M3AUX0
uniprot id: A0A8M3AXX4
uniprot id: A0A8M3AXY0
uniprot id: A0A8M3B5S0
uniprot id: A0A8M6YV41
uniprot id: A0A8M6YVP8
uniprot id: A0A8M6YXG5
uniprot id: A0A8M6Z3K1
uniprot id: A0A8M6Z4A0
uniprot id: A0A8M9P4T5
uniprot id: A0A8M9PSK3
names: Similarity
messages: Belongs to the DOCK family.

7955:rsph10b
gene id: 7955:rsph10b
uniprot id: Q08CH7
names: Function
names: Subcellular Location Annotation
messages: May function as part of axonemal radial spoke complexes. Radial spoke complexes are important for ciliary motility.
messages: cilium axoneme

7955:cnn1a
gene id: 7955:cnn1a
uniprot id: B8A668
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

7955:foxg1a
gene id: 7955:foxg1a
uniprot id: O73862
uniprot id: Q568V0
names: Subcellular Location Annotation
messages: Nucleus

7955:slc5a2
gene id: 7955:slc5a2
uniprot id: Q6NWD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

7955:ches1
gene id: 7955:ches1
uniprot id: A0A8N7UYT9
uniprot id: Q5TYT5
names: Function
names: Subcellular Location Annotation
messages: Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).
messages: Nucleus

7955:atp5e
gene id: 7955:atp5e
uniprot id: F8W3H2
names: Function
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

7955:si:dkey-201i6.2
gene id: 7955:si:dkey-201i6.2
uniprot id: A0A8N7UV51
names: Subcellular Location Annotation
messages: Membrane

7955:cwc25
gene id: 7955:cwc25
uniprot id: Q7ZVW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CWC25 family.
messages: Nucleus

7955:orc3
gene id: 7955:orc3
uniprot id: F1QP75
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC3 family.
messages: Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.
messages: Nucleus

7955:itpr3
gene id: 7955:itpr3
uniprot id: A0A0R4IH08
uniprot id: A0A8M6Z0J4
uniprot id: A0A8M6Z266
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Membrane
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

7955:syt16
gene id: 7955:syt16
uniprot id: A0A8M1RFB6
uniprot id: A0A8M6Z3W6
names: Similarity
messages: Belongs to the synaptotagmin family.

7955:adam17b
gene id: 7955:adam17b
uniprot id: U3JAD1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:rbp2b
gene id: 7955:rbp2b
uniprot id: Q6IVM1
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

7955:junba
gene id: 7955:junba
uniprot id: A0A8M6Z3M3
uniprot id: Q7T367
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

7955:oclnb
gene id: 7955:oclnb
uniprot id: A2BGQ3
uniprot id: Q5PRA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

7955:si:ch211-168k14.2
gene id: 7955:si:ch211-168k14.2
uniprot id: A0A8M6Z0H6
uniprot id: A0A8M6Z873
uniprot id: A0A8M9Q566
names: Similarity
messages: Belongs to the phospholipase D family.

7955:ckba
gene id: 7955:ckba
uniprot id: A0A8M6Z2B4
uniprot id: Q08BV6
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

7955:admp
gene id: 7955:admp
uniprot id: Q8UVQ2
names: Similarity
messages: Belongs to the TGF-beta family.

7955:lmo2
gene id: 7955:lmo2
uniprot id: Q9PTJ3
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: By ets transcription factors including ets1.
messages: During embryogenesis, expressed in hematopoietic and endothelial precursors, including the two stripes of posterior and anterior lateral plate mesoderm at the 1-somite stage that give rise to the primitive blood.
messages: Nucleus
messages: Transcription factor that acts synergistically with tal1/scl in primitive and definitive hematopoiesis, and in endothelial development. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hematopoietic induction cues such as gata1, tal1/scl-lmo2-induced haemangioblasts differentiate into endothelial cells.

7955:si:rp71-17i16.5
gene id: 7955:si:rp71-17i16.5
uniprot id: A0A8M9Q3P0
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

7955:LOC103908772
gene id: 7955:LOC103908772
uniprot id: A0A8M9QGZ0
names: Subcellular Location Annotation
messages: Membrane

7955:qpct
gene id: 7955:qpct
uniprot id: A0A8M3AK24
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

7955:rxfp1
gene id: 7955:rxfp1
uniprot id: A0A2R8QUA1
uniprot id: D9IDV5
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:cacnb4a
gene id: 7955:cacnb4a
uniprot id: A8WHZ5
uniprot id: B0F0D0
names: Similarity
messages: Belongs to the calcium channel beta subunit family.

7955:arrdc1b
gene id: 7955:arrdc1b
uniprot id: A0A8N7TBT1
names: Similarity
messages: Belongs to the arrestin family.

7955:ube2d4
gene id: 7955:ube2d4
uniprot id: A4QNX5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7955:hmox2a
gene id: 7955:hmox2a
uniprot id: A7MD59
names: Similarity
messages: Belongs to the heme oxygenase family.

7955:LOC100006250
gene id: 7955:LOC100006250
uniprot id: A0A8M1Q1R2
names: Similarity
messages: Belongs to the annexin family.

7955:tmem234
gene id: 7955:tmem234
uniprot id: B8A4M2
uniprot id: B8A4M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM234 family.
messages: Membrane

7955:gorasp1b
gene id: 7955:gorasp1b
uniprot id: A0A0H2UJY9
uniprot id: A0A8M1RRZ2
names: Similarity
messages: Belongs to the GORASP family.

7955:si:ch73-22a13.3
gene id: 7955:si:ch73-22a13.3
uniprot id: A0A8M9QBA1
uniprot id: F1QPV9
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

7955:spi1b
gene id: 7955:spi1b
uniprot id: A0A8M2BG46
uniprot id: F1R668
uniprot id: Q78AM8
uniprot id: Q8AW41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

7955:zgc:158482
gene id: 7955:zgc:158482
uniprot id: A2VCY4
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

7955:tle2
gene id: 7955:tle2
uniprot id: A0A8M2BHT3
uniprot id: A0A8M2BHU5
uniprot id: A0A8M2BI83
uniprot id: A0A8M3B5J1
uniprot id: B3DJR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

7955:lzts2a
gene id: 7955:lzts2a
uniprot id: A0A8M3AZ07
uniprot id: B8A6E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LZTS2 family.
messages: Cytoplasm
messages: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
messages: centrosome

7955:pmch
gene id: 7955:pmch
uniprot id: C9W8C3
names: Function
messages: Plays a role in skin pigmentation by antagonizing the action of melanotropin alpha. Induces melanin concentration within the melanophores. May participate in the control of the hypothalamo-pituitary adrenal gland axis by inhibiting the release of ACTH.

7955:ptprt
gene id: 7955:ptprt
uniprot id: A0A8M6YYZ9
uniprot id: A0A8M6YZ05
uniprot id: A0A8M6YZU0
uniprot id: A0A8M6Z1C7
uniprot id: A0A8M6Z701
uniprot id: A0A8M6Z7J7
uniprot id: A0A8M9PNA4
uniprot id: A0A8M9Q0Y4
uniprot id: A0A8M9Q0Y9
uniprot id: A0A8M9Q790
uniprot id: A0A8M9Q794
uniprot id: A0A8M9QBE1
uniprot id: A0A8M9QGE8
uniprot id: A0A8M9QGF1
uniprot id: A0A8N7T7Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

7955:gda
gene id: 7955:gda
uniprot id: Q502E8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

7955:arfgef1
gene id: 7955:arfgef1
uniprot id: A0A2R8Q904
uniprot id: A0A8M3ANJ3
uniprot id: A0A8M3AP80
uniprot id: A0A8M3AZ36
uniprot id: A0A8M3B6N5
uniprot id: E7FGL2
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

7955:rnf152
gene id: 7955:rnf152
uniprot id: A0A8M2BB62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF152 family.
messages: Lysosome membrane
messages: Membrane

7955:ehd2b
gene id: 7955:ehd2b
uniprot id: Q6P3J7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

7955:rnf19b
gene id: 7955:rnf19b
uniprot id: Q1L8L6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBR family. RNF19 subfamily.
messages: Cytoplasmic granule membrane
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells. Protects against staurosporin-induced cell death.
messages: Endoplasmic reticulum membrane
messages: Interacts with UBE2L3, UBE2L6 and UCKL1.
messages: Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain.
messages: The first IBR-type zinc finger is the most crucial for interaction with UBE2L3, UBE2L6 and UCKL1.

7955:slc9a6a
gene id: 7955:slc9a6a
uniprot id: A0A8M3AP93
uniprot id: F1QSJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Endosome membrane
messages: Recycling endosome membrane

7955:si:busm1-52i16.2
gene id: 7955:si:busm1-52i16.2
uniprot id: A0A2R8Q0P2
uniprot id: A0A8M9QFL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

7955:wdr44
gene id: 7955:wdr44
uniprot id: A5PN22
names: Subcellular Location Annotation
messages: trans-Golgi network

7955:vwa9
gene id: 7955:vwa9
uniprot id: Q1LWK5
uniprot id: Q7ZUK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INTS14 family.
messages: Nucleus
messages: Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

7955:pde1ca
gene id: 7955:pde1ca
uniprot id: A0A8M9PY25
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

7955:alas1
gene id: 7955:alas1
uniprot id: Q7T2F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

7955:LOC110438165
gene id: 7955:LOC110438165
uniprot id: A0A8M9PT13
names: Subcellular Location Annotation
messages: Membrane

7955:irf3
gene id: 7955:irf3
uniprot id: A0A8M6Z9B8
uniprot id: B7SEE0
names: Subcellular Location Annotation
messages: Nucleus

7955:dync1li2
gene id: 7955:dync1li2
uniprot id: A0A8M2BDX2
uniprot id: F1RB89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

7955:mst1rb
gene id: 7955:mst1rb
uniprot id: A0A8M9QI71
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:slc2a2
gene id: 7955:slc2a2
uniprot id: Q102R8
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

7955:pimr133
gene id: 7955:pimr133
uniprot id: E7F3T6
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:si:ch1073-153i20.2
gene id: 7955:si:ch1073-153i20.2
uniprot id: A8KBJ5
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:spire1a
gene id: 7955:spire1a
uniprot id: A0A0R4IHM3
uniprot id: A0A0R4ITV6
uniprot id: A0A8M2B6B0
uniprot id: A0A8M2B6P4
uniprot id: A0A8M3AKA9
uniprot id: A0A8M3AL19
uniprot id: A0A8M3B3M7
uniprot id: Q1LYM3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage. In addition, promotes innate immune signaling downstream of dsRNA sensing. Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1.
messages: Belongs to the spire family.
messages: Binds to actin monomers via the WH2 domain.
messages: Cell membrane
messages: Cleavage furrow
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: The Spir-box targets binding to intracellular membrane structures.
messages: cytoskeleton
messages: cytosol
messages: perinuclear region

7955:zgc:63694
gene id: 7955:zgc:63694
uniprot id: A0A8M6Z2B2
uniprot id: A0A8M9Q094
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

7955:hnrnpc
gene id: 7955:hnrnpc
uniprot id: A0A8M6Z8V1
uniprot id: Q803J4
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

7955:ugt5g2
gene id: 7955:ugt5g2
uniprot id: D3XDB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7955:sumf1
gene id: 7955:sumf1
uniprot id: F1QHA4
uniprot id: Q1RM47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

7955:LOC100149234
gene id: 7955:LOC100149234
uniprot id: A0A8M1QV59
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:adamts15a
gene id: 7955:adamts15a
uniprot id: A2BIA3
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

7955:rpe65a
gene id: 7955:rpe65a
uniprot id: Q6PBW5
names: Cofactor
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed at 16 hours post fertilization (hpf) in the pineal gland, a light-sensitive endocrine organ. Expression in the retinal pigment epithelium (RPE) is initiated in the ventronasal patch at 40 hpf, preceding photoreceptor differentiation by a few hours. During subsequent development, expression in the RPE becomes stronger and more widespread, covering the entire RPE except for the cilliary margin by 56 hpf.
messages: Palmitoylated.
messages: Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. Capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (By similarity).
messages: Retinal pigment epithelium-specific.

7955:fndc5b
gene id: 7955:fndc5b
uniprot id: Q1L867
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cell membrane
messages: May mediate beneficial effects of muscular exercise.
messages: N-Glycosylated.
messages: Peroxisome membrane
messages: Secreted
messages: The extracellular domain is cleaved and released from the cell membrane.

7955:dtnbp1a
gene id: 7955:dtnbp1a
uniprot id: A0A8M2B4E2
uniprot id: A0A8M2B4E5
uniprot id: A0A8M2B4E7
uniprot id: A0A8M2B4E8
uniprot id: A0A8M2B4F1
uniprot id: A0A8M2B4X1
uniprot id: A0A8M2B510
uniprot id: A0A8M2B511
uniprot id: A0A8M9NZ68
uniprot id: E9QDJ9
uniprot id: Q7ZWE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dysbindin family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. May be required for normal dopamine homeostasis in the cerebral cortex, hippocampus, and hypothalamus. Plays a role in the regulation of cell surface exposure of DRD2. Contributes to the regulation of dopamine signaling. May play a role in actin cytoskeleton reorganization and neurite outgrowth (By similarity).
messages: Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1).
messages: Cytoplasm
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum
messages: Endosome membrane
messages: Melanosome membrane
messages: Nucleus
messages: Postsynaptic density
messages: synaptic vesicle membrane

7955:unc119b
gene id: 7955:unc119b
uniprot id: Q1RM42
names: Similarity
messages: Belongs to the PDE6D/unc-119 family.

7955:LOC108182769
gene id: 7955:LOC108182769
uniprot id: A0A8M6YXJ7
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:tfcp2l1
gene id: 7955:tfcp2l1
uniprot id: A0A8M9Q4J1
uniprot id: E9QJE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

7955:ankrd34ba
gene id: 7955:ankrd34ba
uniprot id: E9QC15
names: Similarity
messages: Belongs to the ANKRD34 family.

7955:gdf7
gene id: 7955:gdf7
uniprot id: A0A8N7TFB7
names: Similarity
messages: Belongs to the TGF-beta family.

7955:sgta
gene id: 7955:sgta
uniprot id: Q6NXA1
names: Similarity
messages: Belongs to the SGT family.

7955:LOC110439304
gene id: 7955:LOC110439304
uniprot id: A0A8M9PZR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

7955:prickle3
gene id: 7955:prickle3
uniprot id: A0A8M2BEN2
uniprot id: A0A8N7TE34
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

7955:taar14j
gene id: 7955:taar14j
uniprot id: A0A8M1NCA8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:hoxc12b
gene id: 7955:hoxc12b
uniprot id: Q9YGT0
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Expressed both maternally and zygotically, from ova through to 48 hours post-fertilization.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

7955:crygm2d18
gene id: 7955:crygm2d18
uniprot id: Q6IQK6
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:cart4
gene id: 7955:cart4
uniprot id: Q1L893
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

7955:utp11l
gene id: 7955:utp11l
uniprot id: Q7ZUG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

7955:ubald1a
gene id: 7955:ubald1a
uniprot id: B7ZUV8
uniprot id: Q6DGM1
names: Similarity
messages: Belongs to the UBALD family.

7955:tyr
gene id: 7955:tyr
uniprot id: A0A8M1PAD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

7955:tnr
gene id: 7955:tnr
uniprot id: A0A8M2BIJ4
uniprot id: Q7T3T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

7955:znf704
gene id: 7955:znf704
uniprot id: Q1LY51
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: The CR1 and CR2 motifs mediate sequence-specific DNA binding.
messages: Transcription factor.

7955:rx1
gene id: 7955:rx1
uniprot id: Q6P984
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus
messages: Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation.

7955:sco1
gene id: 7955:sco1
uniprot id: E7FD19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCO1/2 family.
messages: Mitochondrion inner membrane

7955:nrd1b
gene id: 7955:nrd1b
uniprot id: A0A0R4IFD3
uniprot id: Q1L985
names: Similarity
messages: Belongs to the peptidase M16 family.

7955:epha7
gene id: 7955:epha7
uniprot id: A0A8M9P2N6
uniprot id: A0A8M9PBU0
uniprot id: A0A8M9PBU2
uniprot id: A0A8M9PHE5
uniprot id: A0A8M9PHF0
uniprot id: A0A8M9PPF8
uniprot id: A0A8M9PST8
uniprot id: Q5VSJ4
names: Subcellular Location Annotation
messages: Membrane

7955:zfx
gene id: 7955:zfx
uniprot id: E7F557
names: Subcellular Location Annotation
messages: Nucleus

7955:tmtops3a
gene id: 7955:tmtops3a
uniprot id: R9R6H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

7955:pcdh2ab3
gene id: 7955:pcdh2ab3
uniprot id: Q60I74
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

7955:stx1b
gene id: 7955:stx1b
uniprot id: Q9I9P6
names: Similarity
messages: Belongs to the syntaxin family.

7955:eef1da
gene id: 7955:eef1da
uniprot id: A0A0R4IA30
uniprot id: A0A8M2BAP5
uniprot id: A0A8M2BAS2
uniprot id: A0A8M2BAX4
uniprot id: A0A8M6Z1P2
uniprot id: A0A8M9QAS6
uniprot id: A0A8M9QG85
uniprot id: A0A8M9QP05
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.

7955:gnrh2
gene id: 7955:gnrh2
uniprot id: Q5Y835
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GnRH family.
messages: Secreted
messages: Stimulates the secretion of gonadotropins.

7955:zgc:112433
gene id: 7955:zgc:112433
uniprot id: A0A0R4IWR0
uniprot id: Q566W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

7955:zgc:56231
gene id: 7955:zgc:56231
uniprot id: Q7ZU82
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:znf330
gene id: 7955:znf330
uniprot id: Q7ZUZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOA36 family.
messages: nucleolus

7955:phka1b
gene id: 7955:phka1b
uniprot id: A0A286YBM7
uniprot id: A0A8M9PJ81
uniprot id: A0A8M9PRF2
uniprot id: A0A8M9PUY3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

7955:c8b
gene id: 7955:c8b
uniprot id: A8HAJ8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:vgll2a
gene id: 7955:vgll2a
uniprot id: Q4V8U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: Nucleus

7955:wdr48b
gene id: 7955:wdr48b
uniprot id: A0A8M2BFQ8
uniprot id: A0A8M2BFR4
uniprot id: Q6PFM9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR48 family.
messages: Cytoplasm
messages: Late endosome
messages: Lysosome
messages: Nucleus
messages: Regulator of deubiquitinating complexes, which acts as a strong activator of usp1, usp12 and usp46. Enhances the usp1-mediated deubiquitination of fancd2; usp1 being almost inactive by itself. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. Also activates deubiquitinating activity of complexes containing usp12. Together with rad51ap1, promotes DNA repair by stimulating rad51-mediated homologous recombination. Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). DNA-binding is required both for usp1-mediated deubiquitination of fancd2 and stimulation of rad51-mediated homologous recombination: both wdr48/uaf1 and rad51ap1 have coordinated role in DNA-binding during these processes. Together with atad5 and by regulating usp1 activity, has a role in pcna-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated pcna. Together with atad5, has a role in recruiting rad51 to stalled forks during replication stress.
messages: The WD repeats are required for the interaction with deubiquitinating enzymes USP1, USP12 and USP46.

7955:adh8b
gene id: 7955:adh8b
uniprot id: Q7T2J4
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

7955:zgc:110366
gene id: 7955:zgc:110366
uniprot id: A0A8M2BAE4
uniprot id: A8DZH9
uniprot id: U3JA33
names: Similarity
messages: Belongs to the aldo/keto reductase family.

7955:lrrc8db
gene id: 7955:lrrc8db
uniprot id: Q08BM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

7955:agtpbp1
gene id: 7955:agtpbp1
uniprot id: A0A0R4IG37
uniprot id: Q4U2V3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins.
messages: Mitochondrion
messages: Nucleus
messages: cytosol

7955:rpl10a
gene id: 7955:rpl10a
uniprot id: A0A8M9QDK8
uniprot id: Q6PC69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

7955:usp33
gene id: 7955:usp33
uniprot id: A5PMR2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of ccp110 in S and G2/M phase, leading to stabilize ccp110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of robo1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of robo1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (arrb1 and arrb2) and beta-2 adrenergic receptor (adrb2). Deubiquitinates dio2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
messages: The UBP-type zinc finger binds 3 zinc ions. However, it does not bind ubiquitin, probably because the conserved Arg in position 55 is replaced by a Glu residue (By similarity).
messages: centrosome
messages: perinuclear region

7955:gpr185b
gene id: 7955:gpr185b
uniprot id: F1QSZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:mpc2
gene id: 7955:mpc2
uniprot id: Q7ZUJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

7955:vegfab
gene id: 7955:vegfab
uniprot id: A0A8M1P9F8
uniprot id: A0A8M2BBS4
uniprot id: A0A8M3B1G0
uniprot id: Q0QYI0
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

7955:LOC556363
gene id: 7955:LOC556363
uniprot id: A0A8M9QD89
names: Subcellular Location Annotation
messages: Membrane

7955:kcnq5b
gene id: 7955:kcnq5b
uniprot id: F1RB62
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:sugp1
gene id: 7955:sugp1
uniprot id: A0A8M1RIH6
uniprot id: A0A8M3AQ46
uniprot id: A0A8M6YWN7
uniprot id: A0A8M9P2J9
uniprot id: A0A8M9PBP7
uniprot id: A0A8M9PPA2
names: Subcellular Location Annotation
messages: Nucleus

7955:vapb
gene id: 7955:vapb
uniprot id: A0A8M9PZG9
uniprot id: Q6P2B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:cnih4
gene id: 7955:cnih4
uniprot id: A0A8N7T6U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

7955:nim1k
gene id: 7955:nim1k
uniprot id: E7F7X7
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:wnk1b
gene id: 7955:wnk1b
uniprot id: A0A8M2BBS9
uniprot id: A0A8M3AR69
uniprot id: A0A8M3AR72
uniprot id: A0A8M3ARF5
uniprot id: A0A8M3ARF9
uniprot id: A0A8M3AYJ7
uniprot id: A0A8M3AYK0
uniprot id: A0A8M3B1I2
uniprot id: A0A8M3B1I6
uniprot id: A0A8M3B8S4
uniprot id: A0A8M3B8S9
uniprot id: A0A8M9PHQ7
uniprot id: A0A8M9Q0Y6
uniprot id: A0A8M9Q681
uniprot id: A0A8M9QBQ4
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

7955:taf5l
gene id: 7955:taf5l
uniprot id: Q6PGV3
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

7955:gjd2b
gene id: 7955:gjd2b
uniprot id: Q8JFD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

7955:LOC562630
gene id: 7955:LOC562630
uniprot id: E7F072
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:pcbd1
gene id: 7955:pcbd1
uniprot id: Q6PBI6
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

7955:LOC100149761
gene id: 7955:LOC100149761
uniprot id: A0A8M3AJF9
names: Similarity
messages: Belongs to the CD225/Dispanin family.

7955:xiap
gene id: 7955:xiap
uniprot id: A2RV08
names: Similarity
messages: Belongs to the IAP family.

7955:adgrg6
gene id: 7955:adgrg6
uniprot id: C6KFA3
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A short peptide sequence (termed the Stachel sequence) in the C-terminal part of the extra-cellular domain (ECD) functions as a tethered agonist. Upon structural changes within the ECD, e.g. due to extracellular ligand binding or mechanical movements, this intramolecular agonist is exposed to the 7TM domain, triggering G-protein activation.
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Cell membrane
messages: Detected from 30 hours post-fertilization to 4 days post-fertilization in Schwann cells of the posterior lateral line nerve.
messages: Expressed in Schwann cells of the posterior lateral line nerve and in brain.
messages: G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins (PubMed:25118328). Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:19745155). Also plays a role in inner ear development (PubMed:24067352).
messages: Morpholino knockdown of the protein results in defects in semicircular canal formation inner ear (PubMed:24067352).
messages: Plays an important role in heart development (PubMed:24082093). Necessary and sufficient for axon sorting by Schwann cells independently of the ADGRG6-CTF (PubMed:25695270).

7955:si:ch73-217b7.1
gene id: 7955:si:ch73-217b7.1
uniprot id: A0A0R4IVW1
uniprot id: A0A8M3ANX8
uniprot id: A0A8M3AYS4
uniprot id: A0A8M3B6E0
uniprot id: A0A8M9P5M7
uniprot id: A0A8M9PLC6
uniprot id: A0A8M9PLD0
uniprot id: A0A8M9PTQ2
uniprot id: A0A8M9PX11
names: Similarity
messages: Belongs to the MAP7 family.

7955:cacna1ha
gene id: 7955:cacna1ha
uniprot id: A0A8M3AR36
uniprot id: A0A8M3AY82
uniprot id: A0A8M3B162
uniprot id: A0A8M9PGJ8
uniprot id: A0A8M9Q5I3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.

7955:gatsl2
gene id: 7955:gatsl2
uniprot id: Q7ZVS6
names: Similarity
messages: Belongs to the GATS family.

7955:ube2v2
gene id: 7955:ube2v2
uniprot id: Q6PEH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Has no ubiquitin ligase activity on its own. The ube2v2/ube2n heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity).
messages: Heterodimer with ube2n.

7955:pkmyt1
gene id: 7955:pkmyt1
uniprot id: A0A8M9QMB9
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:LOC562770
gene id: 7955:LOC562770
uniprot id: A3KPR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:efr3bb
gene id: 7955:efr3bb
uniprot id: Q5SPP5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EFR3 family.
messages: Cell membrane
messages: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, efr3b probably acts as the membrane-anchoring component.
messages: Component of a phosphatidylinositol 4-kinase (PI4K) complex.
messages: Palmitoylated at its N-terminus, anchoring the protein to the plasma membrane.

7955:ccnt2b
gene id: 7955:ccnt2b
uniprot id: Q802D2
names: Similarity
messages: Belongs to the cyclin family.

7955:coq5
gene id: 7955:coq5
uniprot id: Q66L51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least coq3, coq4, coq5, coq6, coq7 and coq9.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

7955:adcy8
gene id: 7955:adcy8
uniprot id: B7UCF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

7955:phyhipla
gene id: 7955:phyhipla
uniprot id: A1A5X6
names: Similarity
messages: Belongs to the PHYHIP family.

7955:prdm8
gene id: 7955:prdm8
uniprot id: B8A5Y1
uniprot id: Q7SXY1
names: Subcellular Location Annotation
messages: Nucleus

7955:zgc:165582
gene id: 7955:zgc:165582
uniprot id: A7E281
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

7955:arsg
gene id: 7955:arsg
uniprot id: A4QP89
names: Similarity
messages: Belongs to the sulfatase family.

7955:prdm4
gene id: 7955:prdm4
uniprot id: A0A8M6YZE3
uniprot id: F1R3R6
names: Subcellular Location Annotation
messages: Nucleus

7955:si:ch211-285c6.1
gene id: 7955:si:ch211-285c6.1
uniprot id: A0A8N7USU2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:fopnl
gene id: 7955:fopnl
uniprot id: I3ITH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: cilium basal body

7955:LOC100001479
gene id: 7955:LOC100001479
uniprot id: A0A8M1PUJ3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:efemp2a
gene id: 7955:efemp2a
uniprot id: Q5PR37
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:rce1a
gene id: 7955:rce1a
uniprot id: E7FA75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U48 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:cap1
gene id: 7955:cap1
uniprot id: Q6YBS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane

7955:ppp1r35
gene id: 7955:ppp1r35
uniprot id: Q0P427
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP1R35 family.
messages: During centriole duplication, may play a role in the centriole elongation by promoting the recruitment of the microtubule-binding elongation machinery, leading to the centriole to centrosome conversion (By similarity). In addition may play a role in the primary cilia assembly (By similarity).
messages: centriole
messages: centrosome

7955:ywhabl
gene id: 7955:ywhabl
uniprot id: Q6P102
uniprot id: Q6PC82
names: Similarity
names: Subunit
messages: Belongs to the 14-3-3 family.
messages: Homodimer, and heterodimer with other family members.

7955:LOC100330007
gene id: 7955:LOC100330007
uniprot id: A0A8M9Q2T5
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:zgc:174153
gene id: 7955:zgc:174153
uniprot id: A8KBT8
names: Similarity
messages: Belongs to the peptidase C1 family.

7955:LOC553528
gene id: 7955:LOC553528
uniprot id: A0A2R8Q2S1
uniprot id: A0A8M3B7N4
uniprot id: E7EZA6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OCIAD1 family.
messages: Endosome
messages: Interacts with STAT3.
messages: Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.
messages: The OCIA domain is necessary and sufficient for endosomal localization.

7955:mms22l
gene id: 7955:mms22l
uniprot id: B3DIY3
uniprot id: F1Q905
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MMS22 family. MMS22L subfamily.
messages: Chromosome
messages: Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication. It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs. Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination. Within the complex, MMS22L acts by binding ssDNA.
messages: Component of the MMS22L-TONSL complex.
messages: Nucleus

7955:zgc:165573
gene id: 7955:zgc:165573
uniprot id: A5PLE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYSTM1 family.
messages: Membrane

7955:ace
gene id: 7955:ace
uniprot id: E7FFA5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M2 family.
messages: Binds 2 Zn(2+) ions per subunit.

7955:rab3c
gene id: 7955:rab3c
uniprot id: A8WHV3
uniprot id: Q6DGH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

7955:kcnq5a
gene id: 7955:kcnq5a
uniprot id: A0A8M9PYN5
uniprot id: A0A8M9QAC3
uniprot id: A0A8M9QG06
uniprot id: A0A8M9QK86
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:kcnt2
gene id: 7955:kcnt2
uniprot id: A0A8M9PST3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:htr5aa
gene id: 7955:htr5aa
uniprot id: A0A0R4IFY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:mettl5
gene id: 7955:mettl5
uniprot id: F1QVR8
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA (By similarity). N6-methylation of adenine(1832) in 18S rRNA resides in the decoding center of 18S rRNA and is required for translation and embryonic stem cells (ESCs) pluripotency and differentiation (By similarity).
messages: Expressed from 20 minutes after fertilization in embryos.
messages: Microcephaly and curved tails.
messages: Nucleus
messages: Postsynapse
messages: Presynapse
messages: rRNA N6-adenosine-methyltransferase activity is inhibited by zinc.

7955:mtmr4
gene id: 7955:mtmr4
uniprot id: A0A8M1RI73
uniprot id: A0A8M3ARV3
uniprot id: A0A8M9PLQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

7955:zgc:101744
gene id: 7955:zgc:101744
uniprot id: B0S784
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

7955:hk1
gene id: 7955:hk1
uniprot id: Q7ZUM3
names: Similarity
messages: Belongs to the hexokinase family.

7955:si:ch73-212j7.1
gene id: 7955:si:ch73-212j7.1
uniprot id: A0A8M2B758
uniprot id: A0A8M2B760
uniprot id: F1RA07
names: Similarity
messages: Belongs to the CEP170 family.

7955:vti1a
gene id: 7955:vti1a
uniprot id: A0A2R8Q5I2
uniprot id: A0A8M3BE99
uniprot id: A0A8M6Z1C2
uniprot id: F1Q7S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

7955:cry1ba
gene id: 7955:cry1ba
uniprot id: A0A8M1P943
uniprot id: Q503J5
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 FAD per subunit.

7955:plac8l1
gene id: 7955:plac8l1
uniprot id: E7FDI5
names: Similarity
messages: Belongs to the cornifelin family.

7955:shha
gene id: 7955:shha
uniprot id: Q1MTB5
uniprot id: Q92008
names: Caution
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the hedgehog family.
messages: Binds calcium and zinc ions; this stabilizes the protein fold and is essential for protein-protein interactions mediated by this domain.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Expressed in the ventral midline of the neural tube and brain. Also found in the notochord and in developing fin bud. In the developing brain, expression occurs in domains that include a discrete region in the floor of the diencephalon.
messages: First detectable in the inner cell layer of the embryonic shield during gastrulation. By 9.5 hours of development, expressed in a continuous band that extends from the tail to the head, the anterior boundary of expression being positioned in the center of the animal pole anterior to the presumptive midbrain.
messages: Golgi apparatus membrane
messages: Interacts with HHATL/GUP1 which negatively regulates HHAT-mediated palmitoylation of the SHH N-terminus (By similarity). Interacts with BOC and CDON (By similarity). Interacts with HHIP (By similarity). Interacts with DISP1 via its cholesterol anchor (By similarity). Interacts with SCUBE2 (By similarity).
messages: Membrane
messages: Multimer.
messages: N-palmitoylation by HHAT of ShhN is required for sonic hedgehog protein N-product multimerization and full activity (By similarity). It is a prerequisite for the membrane-proximal positioning and the subsequent shedding of this N-terminal peptide (By similarity).
messages: The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-terminal fragment (ShhN) (By similarity). Cholesterylation is required for the sonic hedgehog protein N-product targeting to lipid rafts and multimerization (By similarity). ShhN is the active species in both local and long-range signaling, whereas the C-product (ShhC) is degraded in the reticulum endoplasmic (By similarity).
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).
messages: The Cardin-Weintraub (CW) motif is required for heparan sulfate binding of the solubilized ShhNp (By similarity). The N-terminal palmitoylated peptide is cleaved at the Heparan sulfate-binding Cardin-Weintraub (CW) motif site (By similarity). The cleavage reduced the interactions with heparan sulfate. The cleavage is enhanced by SCUBE2 (By similarity).
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.
messages: The dually lipidated sonic hedgehog protein N-product (ShhNp) is a morphogen which is essential for a variety of patterning events during development (By similarity). Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes (PubMed:7583153). Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (By similarity). In the absence of SHH, PTCH1 represses the constitutive signaling activity of SMO (By similarity).
messages: The lipidated N- and C-terminal peptides of ShhNp can be cleaved (shedding) (By similarity). The N-terminal palmitoylated peptide is cleaved at the Cardin-Weintraub (CW) motif site (By similarity). The cleavage reduced the interactions with heparan sulfate (By similarity). The cleavage is enhanced by SCUBE2 (By similarity).
messages: The several steps and mechanisms that permit controlled Shh dispersion and gradient formation remain controversial. The Shh C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity resulting in the cleavage and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-terminal fragment (ShhN). The protein is further modified by covalent addition of palmitate at the N-terminal of ShhN, resulting to the dual-lipidated Shh (ShhNp). ShhNp is firmly tethered to the cell membrane where it forms multimers. Further solubilization and release from the cell surface seem to be achieved through different mechanisms, including the interaction with DISP1 and SCUBE2, movement by lipoprotein particles, transport by cellular extensions called cytonemes or by proteolytic removal of both terminal lipidated peptides. Once released, the fully processed Shh can signal within embryonic tissues both at short and long-range.

7955:ctbp1
gene id: 7955:ctbp1
uniprot id: A0A8M2BKF1
uniprot id: Q7ZU55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

7955:LOC103908680
gene id: 7955:LOC103908680
uniprot id: A3KPR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:ppp3r1a
gene id: 7955:ppp3r1a
uniprot id: A0A8M3BEF6
uniprot id: E9QG20
names: Similarity
messages: Belongs to the calcineurin regulatory subunit family.

7955:LOC100332851
gene id: 7955:LOC100332851
uniprot id: A0A8M9PUD6
uniprot id: A0A8M9QH93
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

7955:slc38a6
gene id: 7955:slc38a6
uniprot id: Q503G8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Cell membrane
messages: Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate.

7955:slc16a9b
gene id: 7955:slc16a9b
uniprot id: Q6DBW3
names: Subcellular Location Annotation
messages: Membrane

7955:gart
gene id: 7955:gart
uniprot id: Q9I9E6
names: Similarity
messages: In the C-terminal section; belongs to the GART family.
messages: In the N-terminal section; belongs to the GARS family.
messages: In the central section; belongs to the AIR synthase family.

7955:xylt2
gene id: 7955:xylt2
uniprot id: A0A8M3AQZ8
uniprot id: B3DIV0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 14 family. XylT subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: Monomer.

7955:arl4ca
gene id: 7955:arl4ca
uniprot id: Q561U6
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

7955:pthlhb
gene id: 7955:pthlhb
uniprot id: Q1L5E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parathyroid hormone family.
messages: Secreted

7955:mxtx1
gene id: 7955:mxtx1
uniprot id: A0JPE5
names: Subcellular Location Annotation
messages: Nucleus

7955:tnc
gene id: 7955:tnc
uniprot id: A0A8M6YY54
uniprot id: E9QHI1
uniprot id: F1QYE2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

7955:gpr180
gene id: 7955:gpr180
uniprot id: A0A8M1RHB2
uniprot id: A0A8M9Q117
names: Subcellular Location Annotation
messages: Membrane

7955:sntb2
gene id: 7955:sntb2
uniprot id: E7FDL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

7955:si:ch211-114l13.10
gene id: 7955:si:ch211-114l13.10
uniprot id: A0A8M6YY09
names: Similarity
messages: Belongs to the NLRP family.

7955:LOC100537940
gene id: 7955:LOC100537940
uniprot id: A0A8M9Q6I5
uniprot id: A0A8M9QFQ7
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:ptk6b
gene id: 7955:ptk6b
uniprot id: Q08BY6
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

7955:kif18a
gene id: 7955:kif18a
uniprot id: Q7ZUW9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:hist2h2l
gene id: 7955:hist2h2l
uniprot id: Q6PC60
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-121 by the BRE1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: Phosphorylated on Ser-15 during apoptosis; which facilitates apoptotic chromatin condensation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:selm
gene id: 7955:selm
uniprot id: A0A8M1PC15
names: Similarity
messages: Belongs to the selenoprotein M/F family.

7955:rnaseh2b
gene id: 7955:rnaseh2b
uniprot id: A0A8M9QJJ8
uniprot id: Q7ZUH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H2 subunit B family.
messages: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Nucleus
messages: The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.

7955:cpt1b
gene id: 7955:cpt1b
uniprot id: F6P7Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

7955:slc8a1a
gene id: 7955:slc8a1a
uniprot id: A0A286YBI0
uniprot id: A0A8M9QLM2
uniprot id: F1R4F4
uniprot id: Q32SG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

7955:cryba2a
gene id: 7955:cryba2a
uniprot id: Q6IQU2
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:neu3.3
gene id: 7955:neu3.3
uniprot id: A0JMM3
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

7955:mut
gene id: 7955:mut
uniprot id: A5D6S3
names: Function
names: Similarity
messages: Belongs to the methylmalonyl-CoA mutase family.
messages: Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.

7955:nav1b
gene id: 7955:nav1b
uniprot id: A0A8M3ATQ4
uniprot id: A0A8M3ATS8
uniprot id: A0A8M3B0T7
uniprot id: A0A8M3B3R1
uniprot id: A0A8M6YZ14
uniprot id: A0A8M6YZ18
uniprot id: A0A8M6YZV2
uniprot id: A0A8M6Z1D6
uniprot id: A0A8M6Z1E1
uniprot id: A0A8M6Z711
uniprot id: A0A8M6Z7K4
uniprot id: A0A8M6Z7K9
uniprot id: A0A8M9QGG3
names: Similarity
messages: Belongs to the Nav/unc-53 family.

7955:zdhhc7
gene id: 7955:zdhhc7
uniprot id: Q6DHI1
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autopalmitoylated.
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Golgi apparatus membrane
messages: Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (Probable).
messages: Homooligomers.
messages: Probably maternally supplied. No zygotic expression is detected before 7.5 hpf.
messages: The DHHC domain is required for palmitoyltransferase activity.

7955:adgra2
gene id: 7955:adgra2
uniprot id: A0A0U2ULT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

7955:exoc6b
gene id: 7955:exoc6b
uniprot id: A0A0R4ILM6
uniprot id: A0A8M3AU30
uniprot id: A0A8M9Q814
uniprot id: A0A8M9QH78
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

7955:irf1a
gene id: 7955:irf1a
uniprot id: Q1RLP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Nucleus

7955:usp32
gene id: 7955:usp32
uniprot id: A0A8M2B4G2
uniprot id: A0A8M3ASU9
uniprot id: E7FCR5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7955:si:ch211-113a14.18
gene id: 7955:si:ch211-113a14.18
uniprot id: R4GEY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

7955:jupb
gene id: 7955:jupb
uniprot id: A0A8M9PS81
names: Similarity
messages: Belongs to the beta-catenin family.

7955:ca6
gene id: 7955:ca6
uniprot id: A0A8M3ANQ1
uniprot id: E9QB97
names: Caution
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reversible hydration of carbon dioxide.

7955:ptch2
gene id: 7955:ptch2
uniprot id: F1Q8S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

7955:prdm2b
gene id: 7955:prdm2b
uniprot id: F1QGQ8
names: Subcellular Location Annotation
messages: Nucleus

7955:crygm1
gene id: 7955:crygm1
uniprot id: Q5XTN6
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:mafaa
gene id: 7955:mafaa
uniprot id: A3KMR8
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Maf subfamily.
messages: Detected first in each somite at the 7-somite stage (12 hpf). By 24 hpf, expressed in each newly formed somite. Expression persists at low levels in each maturing somite until after 35 hpf. At 20 hpf, detected in the hindbrain and in olfactory cells.
messages: Nucleus
messages: Transcription factor, possibly involved in transcription regulation during lens development, including that of crystallin genes (PubMed:11134968). Specifically binds to the alphaCE2 enhancer element of crystallin gene (PubMed:11134968).

7955:cldng
gene id: 7955:cldng
uniprot id: B2GPD3
uniprot id: Q9YH90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Component of tight junction (TJ) strands.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

7955:mccc2
gene id: 7955:mccc2
uniprot id: Q6NWI5
names: Similarity
messages: Belongs to the AccD/PCCB family.

7955:smpx
gene id: 7955:smpx
uniprot id: Q6GMK5
names: Function
names: Similarity
messages: Belongs to the SMPX family.
messages: Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.

7955:insl3
gene id: 7955:insl3
uniprot id: Q2P9V5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted
messages: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.

7955:id2a
gene id: 7955:id2a
uniprot id: Q7SZQ2
names: Subcellular Location Annotation
messages: Nucleus

7955:uts2r
gene id: 7955:uts2r
uniprot id: E7F7E1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:sfxn3
gene id: 7955:sfxn3
uniprot id: A1L257
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

7955:thtpa
gene id: 7955:thtpa
uniprot id: A0A8M1QKV1
uniprot id: A0A8M2B9I1
uniprot id: E9QBE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThTPase family.
messages: Cytoplasm
messages: Hydrolase highly specific for thiamine triphosphate (ThTP).
messages: Monomer.

7955:inab
gene id: 7955:inab
uniprot id: F1Q8F1
names: Similarity
messages: Belongs to the intermediate filament family.

7955:clk2b
gene id: 7955:clk2b
uniprot id: A0A8M9PD83
uniprot id: Q08C37
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:clip1b
gene id: 7955:clip1b
uniprot id: A0A8M9Q6S9
names: Subcellular Location Annotation
messages: cytoskeleton

7955:aldoab
gene id: 7955:aldoab
uniprot id: Q6P043
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

7955:cep57
gene id: 7955:cep57
uniprot id: A1L249
names: Similarity
messages: Belongs to the translokin family.

7955:znrf2b
gene id: 7955:znrf2b
uniprot id: Q08CN9
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Lysosome membrane
messages: May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
messages: Presynaptic cell membrane

7955:pde8b
gene id: 7955:pde8b
uniprot id: A0A8M3ATN7
uniprot id: A0A8M3AWN1
uniprot id: A0A8M9P3K9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

7955:si:ch211-194m7.4
gene id: 7955:si:ch211-194m7.4
uniprot id: A0A8M1RRZ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:ccl20a.3
gene id: 7955:ccl20a.3
uniprot id: B3DGM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

7955:tg
gene id: 7955:tg
uniprot id: A0A193GP06
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:onecut3b
gene id: 7955:onecut3b
uniprot id: A0A8M6Z2N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

7955:cpxm2
gene id: 7955:cpxm2
uniprot id: A0A8M9Q9B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

7955:krr1
gene id: 7955:krr1
uniprot id: A0A8M1NAE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: nucleolus

7955:sla2
gene id: 7955:sla2
uniprot id: A0A8M6Z4G2
names: Subcellular Location Annotation
messages: Cytoplasm

7955:glrx3
gene id: 7955:glrx3
uniprot id: Q5XJ54
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer; the homodimer is independent of 2Fe-2S clusters. Heterotrimer; forms a heterotrimeric complex composed by two bola2 molecules and one glrx3 molecule; linked by [2Fe-2S] clusters.
messages: Morpholino knockdown in embryos reducing the levels of grx3 protein to 40% severely impairs the synthesis of heme and the maturation of hemoglobin, and results in individuals with fewer red blood cells.
messages: The thioredoxin domain lacks the two redox-active cysteines. This strongly suggests that it lacks thioredoxin activity.
messages: Together with bola2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (By similarity). Required for hemoglobin maturation (PubMed:23615448). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity (By similarity).
messages: cytosol

7955:immp2l
gene id: 7955:immp2l
uniprot id: Q6AZD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family. IMP2 subfamily.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Mitochondrion inner membrane

7955:or102-1
gene id: 7955:or102-1
uniprot id: Q2PRB7
uniprot id: Q9I8Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:syf2
gene id: 7955:syf2
uniprot id: Q6DGP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYF2 family.
messages: Identified in the spliceosome C complex.
messages: Involved in pre-mRNA splicing as component of the spliceosome.
messages: Nucleus

7955:cacna1ba
gene id: 7955:cacna1ba
uniprot id: A0A8M3ASG9
uniprot id: A0A8M3AZM5
uniprot id: A0A8M3B2I1
uniprot id: A0A8M3B9N2
uniprot id: A0A8M6YY83
uniprot id: A0A8M6Z0K7
uniprot id: A0A8M6Z6W1
uniprot id: A0A8M9PK68
uniprot id: A0A8M9PXL9
uniprot id: A0A8M9PXN1
uniprot id: A0A8M9Q3C7
uniprot id: A0A8M9Q3D8
uniprot id: A0A8M9Q8N7
uniprot id: A0A8M9Q8P2
uniprot id: A0A8M9QDZ5
uniprot id: A0A8M9QE01
uniprot id: A2BHF4
uniprot id: T2B1R0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.

7955:slc2a12
gene id: 7955:slc2a12
uniprot id: Q6NWF1
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Expressed in the main insulin-sensitive tissues, such as cardiac muscle, skeletal muscle and adipose tissue.
messages: Insulin-regulated facilitative glucose transporter.
messages: Morpholino knockdown of the protein impairs the development of the embryonic heart resulting in abnormal valve formation (PubMed:25326603). Embryos also show poor glycemic control (PubMed:25326603).
messages: perinuclear region

7955:or109-6
gene id: 7955:or109-6
uniprot id: Q2PRJ4
names: Subcellular Location Annotation
messages: Membrane

7955:rfx2
gene id: 7955:rfx2
uniprot id: A0A8M2BEA3
uniprot id: A0A8M2BEC2
uniprot id: Q5EAP5
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RFX family.
messages: Cytoplasm
messages: Homodimer. Heterodimer; heterodimerizes with other rfx proteins.
messages: Nucleus
messages: Reduced cilia length in the Kupffer's vesicle and impaired left-right asymmetry.
messages: Transcription factor that acts as a key regulator of ciliogenesis (PubMed:22233545). Specifically regulates expression of genes required for cilium assembly and function (PubMed:22233545). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (By similarity).

7955:hspa9
gene id: 7955:hspa9
uniprot id: Q5XJ12
names: Similarity
messages: Belongs to the heat shock protein 70 family.

7955:LOC101883670
gene id: 7955:LOC101883670
uniprot id: A0A8M9PZI0
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:fam214a
gene id: 7955:fam214a
uniprot id: A0A0A0MPN7
uniprot id: A0A2R8QHZ7
uniprot id: A0A8M3AS41
uniprot id: A0A8M9P132
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATOS family.
messages: Nucleus

7955:calr3b
gene id: 7955:calr3b
uniprot id: A0A0R4IL29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

7955:LOC101882631
gene id: 7955:LOC101882631
uniprot id: A0A8M2BE40
names: Subcellular Location Annotation
messages: Membrane

7955:slc7a5
gene id: 7955:slc7a5
uniprot id: A0A0R4IFJ3
uniprot id: A0A8M3APL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Cell membrane
messages: Membrane

7955:rps5
gene id: 7955:rps5
uniprot id: Q6PC80
uniprot id: Q8JHH3
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

7955:nkx6.2
gene id: 7955:nkx6.2
uniprot id: A0A0R4IY89
names: Subcellular Location Annotation
messages: Nucleus

7955:kif23
gene id: 7955:kif23
uniprot id: A0A286Y967
uniprot id: A0A8M9P0Y6
uniprot id: A0A8M9PLX5
uniprot id: Q9PUU5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:ppp2r5eb
gene id: 7955:ppp2r5eb
uniprot id: A0A8M6Z943
uniprot id: Q7ZUQ2
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.

7955:adamts18
gene id: 7955:adamts18
uniprot id: A0A8M9PQ18
uniprot id: E7FEJ5
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

7955:cyhr1
gene id: 7955:cyhr1
uniprot id: Q08CH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZFTRAF1 family.
messages: Cytoplasm
messages: perinuclear region

7955:pfkfb4a
gene id: 7955:pfkfb4a
uniprot id: Q32LS8
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

7955:dph6
gene id: 7955:dph6
uniprot id: A0A8M6YVL6
uniprot id: A2RV01
names: Function
names: Similarity
messages: Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EEF2) to diphthamide (By similarity).
messages: Belongs to the Diphthine--ammonia ligase family.

7955:s1pr4
gene id: 7955:s1pr4
uniprot id: F1QC10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:cables2a
gene id: 7955:cables2a
uniprot id: A0A8M2B986
uniprot id: A0A8M9Q830
names: Similarity
messages: Belongs to the cyclin family.

7955:mybl1
gene id: 7955:mybl1
uniprot id: A0A8M2B9R3
uniprot id: A0A8M6YWG1
uniprot id: A0A8M6YYA7
uniprot id: E7FFJ6
names: Subcellular Location Annotation
messages: Nucleus

7955:tekt2
gene id: 7955:tekt2
uniprot id: A0A8M3AKU0
uniprot id: Q567M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: flagellum

7955:celf1
gene id: 7955:celf1
uniprot id: A0A8M2BGA1
uniprot id: A0A8M2BGA2
uniprot id: A0A8M2BGA3
uniprot id: A0A8M2BGB8
uniprot id: A0A8M2BGC2
uniprot id: A0A8M2BGX4
uniprot id: A0A8M3AUD4
uniprot id: A0A8M3AUE0
uniprot id: A0A8M3AUE5
uniprot id: A0A8M3AUE9
uniprot id: A0A8M3B1C3
uniprot id: A0A8M3B1C7
uniprot id: A0A8M3B487
uniprot id: A0A8M3B493
uniprot id: A0A8M3BB44
uniprot id: A0A8M3BB48
uniprot id: A0A8M9PP42
uniprot id: A0A8M9Q1S9
uniprot id: A0A8M9QH64
uniprot id: Q9IBD0
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Expressed in the vegetal cortex of the oocyte. Expressed uniformly in the embryo. Expressed in the vegetal pole at 0.08 hour post-fertilization (hpf). Expressed in the lens fiber cells at 24 hpf and in the blastodisc of the zygote at 30 hpf.
messages: Nucleus
messages: RNA-binding protein implicated in the regulation of several post-transcriptional events. May be involved in mRNA translation activation and stability (By similarity). Involved in the regulation of muscle-specific splicing of alpha actinin pre-mRNAs via the binding to the UR-repeat element (URE) at the branch point of the non-muscle (NM) exon.

7955:gpd1l
gene id: 7955:gpd1l
uniprot id: Q5XIZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Plays a role in regulating cardiac sodium current.

7955:cers4b
gene id: 7955:cers4b
uniprot id: A0A8M2BAR8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

7955:nav1a
gene id: 7955:nav1a
uniprot id: A0A2R8QLY4
uniprot id: A0A8M6YVD2
uniprot id: E7FBA8
names: Similarity
messages: Belongs to the Nav/unc-53 family.

7955:hbs1l
gene id: 7955:hbs1l
uniprot id: A0A8M6YV72
uniprot id: F1Q5Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm

7955:LOC101883792
gene id: 7955:LOC101883792
uniprot id: A0A8M2BH92
names: Subcellular Location Annotation
messages: Nucleus

7955:cyp2p10
gene id: 7955:cyp2p10
uniprot id: A0A8M2B7E8
uniprot id: A0A8M3B1F6
uniprot id: Q7ZU60
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:dars
gene id: 7955:dars
uniprot id: A0AUR8
names: Function
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.

7955:LOC792944
gene id: 7955:LOC792944
uniprot id: A0A8M1PRT0
names: Subcellular Location Annotation
messages: Membrane

7955:serpinb1l4
gene id: 7955:serpinb1l4
uniprot id: F8W475
names: Similarity
messages: Belongs to the serpin family.

7955:eif2b4
gene id: 7955:eif2b4
uniprot id: A0A286Y8J6
uniprot id: A0A8M2B7A1
uniprot id: A0A8M2B7A3
uniprot id: Q5RIE1
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

7955:sgms1
gene id: 7955:sgms1
uniprot id: A0JMN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

7955:acot16
gene id: 7955:acot16
uniprot id: A0A8M9PV48
uniprot id: A0A8M9Q141
uniprot id: A0A8M9Q6D0
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

7955:sult2st1
gene id: 7955:sult2st1
uniprot id: E7F734
uniprot id: Q6P2U4
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

7955:caspbl
gene id: 7955:caspbl
uniprot id: A0A2U9DQQ6
uniprot id: B8A526
names: Similarity
messages: Belongs to the peptidase C14A family.

7955:LOC571582
gene id: 7955:LOC571582
uniprot id: A0A0G2KPB1
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:vgll2b
gene id: 7955:vgll2b
uniprot id: Q499A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: Nucleus

7955:cope
gene id: 7955:cope
uniprot id: Q5U3E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPE family.
messages: Cytoplasm
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

7955:he2
gene id: 7955:he2
uniprot id: A4VCG4
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:acadvl
gene id: 7955:acadvl
uniprot id: Q7T2C2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

7955:slc44a5a
gene id: 7955:slc44a5a
uniprot id: F1R5E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

7955:cebp1
gene id: 7955:cebp1
uniprot id: A0A8M9PFU8
uniprot id: Q90ZW4
names: Similarity
messages: Belongs to the bZIP family. C/EBP subfamily.

7955:parp2
gene id: 7955:parp2
uniprot id: A0A8M9QIR2
uniprot id: F1QAF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

7955:rorab
gene id: 7955:rorab
uniprot id: A0A1D5NSP3
uniprot id: A0A8M6YZZ4
uniprot id: A0A8M9QBZ9
uniprot id: F1QJF4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Detectable from a late gastrula stage (10 hpf). Very weakly expressed in the midbrain region at the 14-somite stage. Expression in the midbrain intensifies and extends along the anterior- posterior axis as embryogenesis proceeded. At 2 dpf, strongly expressed in the developing eyes and midbrain region. At 3 dpf, expressed in the retina.
messages: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) (By similarity). Required for proper cerebellum development (By similarity).
messages: Nucleus

7955:LOC100534937
gene id: 7955:LOC100534937
uniprot id: A0A8M3AY64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
messages: Secreted

7955:ext1b
gene id: 7955:ext1b
uniprot id: A0JMJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane

7955:ora2
gene id: 7955:ora2
uniprot id: A5H1X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:si:dkey-26i13.6
gene id: 7955:si:dkey-26i13.6
uniprot id: A0A8M1RER3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:mtnr1ab
gene id: 7955:mtnr1ab
uniprot id: F1QHL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity.
messages: Membrane

7955:lnpb
gene id: 7955:lnpb
uniprot id: A0A8M2BD13
uniprot id: F1QDW0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.
messages: Plays a role in determining ER morphology.
messages: The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.

7955:setb
gene id: 7955:setb
uniprot id: A0A8M2B801
uniprot id: Q6TGU0
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

7955:rxraa
gene id: 7955:rxraa
uniprot id: A0A8M2B855
uniprot id: A0A8M2B8E9
uniprot id: F1Q4V9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

7955:trnau1apb
gene id: 7955:trnau1apb
uniprot id: A0A8M9Q082
uniprot id: F1QXG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TRSPAP family.
messages: Cytoplasm
messages: Nucleus

7955:cox14
gene id: 7955:cox14
uniprot id: A8E7D3
names: Function
names: Subcellular Location Annotation
messages: Mitochondrion membrane
messages: Plays a role in the assembly or stability of the cytochrome c oxidase complex (COX).

7955:pald1a
gene id: 7955:pald1a
uniprot id: Q803E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paladin family.
messages: cytosol

7955:LOC110439971
gene id: 7955:LOC110439971
uniprot id: A0A8M9QIA6
names: Similarity
messages: Belongs to the histone H2B family.

7955:cacna1ab
gene id: 7955:cacna1ab
uniprot id: A0A8M6Z3D5
uniprot id: A0A8M9PUZ6
uniprot id: A0A8M9PV04
uniprot id: A0A8M9PV10
uniprot id: A0A8M9Q7A3
uniprot id: A0A8M9Q7B0
uniprot id: A0A8M9Q7B5
uniprot id: A0A8M9QD59
uniprot id: A0A8M9QD65
uniprot id: A0A8M9QD71
uniprot id: A0A8M9QHQ9
uniprot id: A0A8M9QHR4
uniprot id: A0A8M9QHR9
uniprot id: A0A8M9QLP2
uniprot id: A0A8M9QLP7
uniprot id: A0A8M9QLQ1
uniprot id: F8W3Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane

7955:mnd1
gene id: 7955:mnd1
uniprot id: E9QC10
uniprot id: Q6DC61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MND1 family.
messages: Nucleus
messages: Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.
messages: Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks (By similarity).

7955:hdac9b
gene id: 7955:hdac9b
uniprot id: A0A8M2B4U1
uniprot id: Q6PBI4
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting other histone deacetylases. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription (By similarity).
messages: Homodimer. Interacts with mef2 (By similarity).
messages: Intron retention.
messages: Nucleus

7955:ing2
gene id: 7955:ing2
uniprot id: Q6DHF1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

7955:zgc:158296
gene id: 7955:zgc:158296
uniprot id: A1L1S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

7955:tfdp2
gene id: 7955:tfdp2
uniprot id: Q6TNQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

7955:tmed6
gene id: 7955:tmed6
uniprot id: E7F154
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:elp2
gene id: 7955:elp2
uniprot id: A0A286Y893
uniprot id: A0A8M9PGH1
uniprot id: Z4YI78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ELP2 family.
messages: Cytoplasm
messages: Nucleus

7955:LOC100334962
gene id: 7955:LOC100334962
uniprot id: A0A0G2KIS6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:necap1
gene id: 7955:necap1
uniprot id: Q6PC36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

7955:LOC558044
gene id: 7955:LOC558044
uniprot id: A0A8M2BCL2
uniprot id: A0A8M2BCP3
uniprot id: A0A8M9PK72
uniprot id: A0A8M9PXP3
uniprot id: F1QXB0
names: Similarity
messages: Belongs to the spectrin family.

7955:idh3b
gene id: 7955:idh3b
uniprot id: A0A2R8QPC9
uniprot id: Q6IQR5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

7955:si:ch73-368j24.13
gene id: 7955:si:ch73-368j24.13
uniprot id: A4FVM2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:bud23
gene id: 7955:bud23
uniprot id: A3KNP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.
messages: Cytoplasm
messages: Nucleus

7955:fam126a
gene id: 7955:fam126a
uniprot id: A0A8M3ASA0
uniprot id: A0A8M9PRF6
uniprot id: Q6P121
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Hyccin family.
messages: Cell membrane
messages: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis.
messages: Component of a phosphatidylinositol 4-kinase (PI4K) complex.
messages: Membrane
messages: cytosol

7955:si:ch211-244o22.2
gene id: 7955:si:ch211-244o22.2
uniprot id: A0A286Y9L2
uniprot id: A2CEF0
names: Subcellular Location Annotation
messages: Nucleus

7955:pygl
gene id: 7955:pygl
uniprot id: Q5RKM9
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

7955:hdgfrp2
gene id: 7955:hdgfrp2
uniprot id: A0A8M3AN22
uniprot id: Q5XXA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HDGF family.
messages: Cytoplasm
messages: May act as a regulator of myogenesis (By similarity). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (By similarity).
messages: Nucleus

7955:zgc:77158
gene id: 7955:zgc:77158
uniprot id: F1R4M7
uniprot id: Q6P0C2
names: Subcellular Location Annotation
messages: Membrane

7955:si:ch211-240b21.4
gene id: 7955:si:ch211-240b21.4
uniprot id: A0A8M2BCE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

7955:si:dkey-163m14.2
gene id: 7955:si:dkey-163m14.2
uniprot id: E7F2S6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:fpr1
gene id: 7955:fpr1
uniprot id: E7FF45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

7955:slc29a3
gene id: 7955:slc29a3
uniprot id: A0A8M9QA23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

7955:nxph1
gene id: 7955:nxph1
uniprot id: A0A8M1N0Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

7955:dlg1
gene id: 7955:dlg1
uniprot id: A0A8M2BD74
uniprot id: A0A8M2BD78
uniprot id: A0A8M2BD79
uniprot id: A0A8M2BD80
uniprot id: A0A8M2BD84
uniprot id: A0A8M2BD86
uniprot id: A0A8M2BD88
uniprot id: A0A8M2BDA2
uniprot id: A0A8M2BDA9
uniprot id: A0A8M2BDB9
uniprot id: A0A8M2BDE8
uniprot id: A0A8M2BDF3
uniprot id: A0A8M3ATC7
uniprot id: A0A8M3B0G8
uniprot id: A0A8M3B3F8
uniprot id: A0A8M9PLT3
uniprot id: A0A8M9PZE0
uniprot id: A0A8M9PZE5
uniprot id: A0A8M9Q5X6
uniprot id: A0A8M9QA35
uniprot id: A0A8M9QF49
uniprot id: Q5PYH6
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: At 4 days-post-fertilization (dpf), expressed in the inner and outer plexiform layers and the ganglion cell layer of the retina, the marginal zone of the tegmentum, and in the developing craniofacial cartilage.
messages: Belongs to the MAGUK family.
messages: Cell junction
messages: Endoplasmic reticulum membrane
messages: Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction and cell proliferation (By similarity). May play a role in synapse assembly and function.
messages: Membrane

7955:kcnj1a.3
gene id: 7955:kcnj1a.3
uniprot id: Q1LUX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

7955:entpd8
gene id: 7955:entpd8
uniprot id: F1QCU4
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

7955:alkbh8
gene id: 7955:alkbh8
uniprot id: A0A8M9P8I1
uniprot id: E9QB52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkB family.
messages: Cytoplasm

7955:tmem63ba
gene id: 7955:tmem63ba
uniprot id: A0A0R4IKF9
uniprot id: A0A2R8S024
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

7955:pfkpa
gene id: 7955:pfkpa
uniprot id: A0A0R4ITA8
uniprot id: A0A2R8RK99
uniprot id: A0A8M1RMR9
uniprot id: A0A8M2B9C5
uniprot id: A0A8M2B9K3
uniprot id: A0A8M3B6I6
uniprot id: E7FDP2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:zgc:101564
gene id: 7955:zgc:101564
uniprot id: B0S6J4
names: Similarity
messages: Belongs to the FAM72 family.

7955:psmd8
gene id: 7955:psmd8
uniprot id: Q6IQH4
names: Similarity
messages: Belongs to the proteasome subunit S14 family.

7955:erfl1
gene id: 7955:erfl1
uniprot id: A0A8M3ATG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

7955:dock2-like
gene id: 7955:dock2-like
uniprot id: A0A8M9PZD8
names: Similarity
messages: Belongs to the DOCK family.

7955:LOC108191509
gene id: 7955:LOC108191509
uniprot id: F1QTD9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:ehf
gene id: 7955:ehf
uniprot id: A0A8M2B9Y6
uniprot id: Q29R87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

7955:cdk14
gene id: 7955:cdk14
uniprot id: A0A8M9PD73
uniprot id: A0A8M9PMK5
uniprot id: A8WG02
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:aldh3a1
gene id: 7955:aldh3a1
uniprot id: A0A8M2B3W0
uniprot id: X1WBM4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

7955:esrrga
gene id: 7955:esrrga
uniprot id: A0A8M2B590
uniprot id: A0A8M9P8U5
uniprot id: A0A8M9PE48
uniprot id: A0A8M9PKM0
uniprot id: A0A8M9PNM6
uniprot id: A0A8M9PNM9
uniprot id: F6PD98
uniprot id: Q6Q6F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

7955:ubr1
gene id: 7955:ubr1
uniprot id: A0A8M9P0T8
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

7955:atp5ia
gene id: 7955:atp5ia
uniprot id: A7YY99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase e subunit family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

7955:si:ch211-139n6.11
gene id: 7955:si:ch211-139n6.11
uniprot id: A0A8M6Z339
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:scml4
gene id: 7955:scml4
uniprot id: A0A8M1PRS4
uniprot id: A0A8M2B7N5
uniprot id: A0A8M3B494
uniprot id: A0A8M9PPY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

7955:tbcb
gene id: 7955:tbcb
uniprot id: Q803K6
names: Similarity
messages: Belongs to the TBCB family.

7955:map2k4a
gene id: 7955:map2k4a
uniprot id: A0A8M2BBT8
uniprot id: A0A8M3B0Q3
uniprot id: B1NA68
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:srd5a1
gene id: 7955:srd5a1
uniprot id: A5PMI4
uniprot id: Q08C19
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Microsome membrane

7955:kynu
gene id: 7955:kynu
uniprot id: A0A0R4IQY2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:exoc3l2a
gene id: 7955:exoc3l2a
uniprot id: A0A8N7TEH3
names: Similarity
messages: Belongs to the SEC6 family.

7955:mfge8b
gene id: 7955:mfge8b
uniprot id: A0A2R8QFX4
uniprot id: A2RRT1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:hif1ab
gene id: 7955:hif1ab
uniprot id: Q6EHI4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7955:cdcp2
gene id: 7955:cdcp2
uniprot id: A0A8M9PHE2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:npm3
gene id: 7955:npm3
uniprot id: Q5BLA5
names: Similarity
messages: Belongs to the nucleoplasmin family.

7955:sgk3
gene id: 7955:sgk3
uniprot id: A4IG56
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

7955:LOC100331349
gene id: 7955:LOC100331349
uniprot id: A0A8M6Z360
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:lta
gene id: 7955:lta
uniprot id: Q4W897
names: Similarity
messages: Belongs to the tumor necrosis factor family.

7955:zbtb8os
gene id: 7955:zbtb8os
uniprot id: Q566V0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archease family.
messages: Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB. Together with ddx1, acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (By similarity).
messages: Component of the tRNA-splicing ligase complex.

7955:esyt3
gene id: 7955:esyt3
uniprot id: B0UYL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:tgm1l3
gene id: 7955:tgm1l3
uniprot id: A0A8M1Q6T7
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

7955:zgc:114181
gene id: 7955:zgc:114181
uniprot id: A0A8M1P6T9
uniprot id: A0A8M9P806
names: Similarity
messages: Belongs to the peptidase M20A family.

7955:kcnk12
gene id: 7955:kcnk12
uniprot id: A0A8M9QFM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

7955:dkk1b
gene id: 7955:dkk1b
uniprot id: Q9PWH3
uniprot id: Q9W6D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

7955:cdk5rap3
gene id: 7955:cdk5rap3
uniprot id: Q6IQA6
names: Similarity
messages: Belongs to the CDK5RAP3 family.

7955:tuba1a
gene id: 7955:tuba1a
uniprot id: Q6NWK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

7955:tmem177
gene id: 7955:tmem177
uniprot id: Q6PBI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM177 family.
messages: Mitochondrion inner membrane
messages: Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein.

7955:si:ch211-113a14.15
gene id: 7955:si:ch211-113a14.15
uniprot id: F1R4A4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:huwe1
gene id: 7955:huwe1
uniprot id: A0A8M2B950
uniprot id: A0A8M2B9D5
uniprot id: A0A8M3AVJ4
uniprot id: A0A8M9PE41
uniprot id: A0A8M9PX07
uniprot id: A0A8M9Q812
names: Similarity
messages: Belongs to the UPL family. TOM1/PTR1 subfamily.

7955:si:ch73-380n15.2
gene id: 7955:si:ch73-380n15.2
uniprot id: A0A8M9PEJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:LOC100331938
gene id: 7955:LOC100331938
uniprot id: A0A0G2KN81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

7955:mtnr1al
gene id: 7955:mtnr1al
uniprot id: A0A8M1NRI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity.
messages: Membrane

7955:fbxw11b
gene id: 7955:fbxw11b
uniprot id: A0A2R8RWN9
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: At 4 days post fertilization (dpf), it is widely expressed in the brain and eyes. There are high levels of expression in the retinal ganglion layer, the inner nuclear layer, the photoreceptor layer, the ciliary marginal zone, jaw mesenchyme, oral epithelia, and pectoral fins.
messages: Cytoplasm
messages: Knockdown of both fbxw11a and fbxw11b results in abnormally developed pectoral fins and heart edema by day 3 post-fertilization (3 dpf). At 5 dpf, knocked-down embryos show periocular edema, small and misshapen eyes, and abnormal development of the jaw.
messages: Nucleus
messages: Self-associates. Component of the SCF(FBXW11) complex.
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Probably recognizes and binds to phosphorylated target proteins: the interaction with substrates requires the phosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S (By similarity). SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling regulation (By similarity). Participates in Wnt signaling regulation, and plays a role in eye and jaw development (PubMed:31402090). SCF(FBXW11) plays a key role in NF-kappa-B activation by mediating ubiquitination of phosphorylated NFKBIA, leading to its degradation by the proteasome, thereby allowing the associated NF-kappa-B complex to translocate into the nucleus and to activate transcription (By similarity).
messages: The N-terminal D domain mediates homodimerization.

7955:crygmxl2
gene id: 7955:crygmxl2
uniprot id: Q4VBU2
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:znrd1
gene id: 7955:znrd1
uniprot id: Q1LWR1
uniprot id: Q5BL98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.
messages: nucleolus

7955:b3gnt2a
gene id: 7955:b3gnt2a
uniprot id: A0A8M2B700
uniprot id: Q8UWM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:tbpl1
gene id: 7955:tbpl1
uniprot id: Q5U385
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Cytoplasm
messages: Nucleus
messages: Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box (By similarity). Members of the TBP family are differentially required to regulate transcription and development during early embryogenesis.

7955:wnt2
gene id: 7955:wnt2
uniprot id: Q92048
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: First detected in the developing viscera at 30 hours. Expression is gone by 5 days.
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Secreted
messages: extracellular matrix

7955:myo1f
gene id: 7955:myo1f
uniprot id: B0S6F2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:si:dkey-127k13.1
gene id: 7955:si:dkey-127k13.1
uniprot id: A0A8M1PVE2
uniprot id: A0A8M3APV8
names: Similarity
messages: Belongs to the PWWP3A family.

7955:tpd52l1
gene id: 7955:tpd52l1
uniprot id: A0A8M2B7R8
uniprot id: A0A8M2B7S0
uniprot id: A0A8M2B812
uniprot id: A0A8M3ATF1
uniprot id: A0A8M3AWF8
uniprot id: Q503Z0
names: Similarity
messages: Belongs to the TPD52 family.

7955:lim2.2
gene id: 7955:lim2.2
uniprot id: Q45RH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

7955:LOC100329477
gene id: 7955:LOC100329477
uniprot id: A0A8M9Q4D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

7955:fam173b
gene id: 7955:fam173b
uniprot id: E7EXV0
uniprot id: E9QHP4
uniprot id: F1QDF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANT/ATPSC lysine N-methyltransferase family.
messages: Mitochondrion membrane

7955:xkr8.1
gene id: 7955:xkr8.1
uniprot id: A0A8M3AK91
uniprot id: E7F2E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

7955:zgc:163061
gene id: 7955:zgc:163061
uniprot id: A4QN90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

7955:st6galnac
gene id: 7955:st6galnac
uniprot id: A0A8M9QN27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

7955:psme3
gene id: 7955:psme3
uniprot id: Q7ZU20
names: Similarity
messages: Belongs to the PA28 family.

7955:cpsf3
gene id: 7955:cpsf3
uniprot id: Q6DRG6
names: Subcellular Location Annotation
messages: Nucleus

7955:taar19k
gene id: 7955:taar19k
uniprot id: A0A8M1RRA2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:si:ch211-220d9.3
gene id: 7955:si:ch211-220d9.3
uniprot id: A0A8M9QDT0
names: Subcellular Location Annotation
messages: cilium axoneme

7955:hpx
gene id: 7955:hpx
uniprot id: Q6PHG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hemopexin family.
messages: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
messages: Secreted

7955:vps37b
gene id: 7955:vps37b
uniprot id: A3KGZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

7955:crygs3
gene id: 7955:crygs3
uniprot id: Q5XTN7
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:chst2a
gene id: 7955:chst2a
uniprot id: A5PM89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

7955:enpp2
gene id: 7955:enpp2
uniprot id: A0A8M3AIW9
uniprot id: Q6PGY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Secreted

7955:loxl5b
gene id: 7955:loxl5b
uniprot id: A0A8M6Z7N5
uniprot id: A6MH35
uniprot id: F1QGY9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

7955:si:ch211-71m22.1
gene id: 7955:si:ch211-71m22.1
uniprot id: A0A8M3AZ51
uniprot id: A5WVT4
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

7955:rpl23a
gene id: 7955:rpl23a
uniprot id: Q6Q416
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

7955:trpc2b
gene id: 7955:trpc2b
uniprot id: Q4VDB0
names: Subcellular Location Annotation
messages: Membrane

7955:zgc:101540
gene id: 7955:zgc:101540
uniprot id: Q5PRD9
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

7955:pomcb
gene id: 7955:pomcb
uniprot id: A0A8M1NCD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POMC family.
messages: Endogenous opiate.
messages: Secreted
messages: Stimulates the adrenal glands to release cortisol.

7955:apom
gene id: 7955:apom
uniprot id: A0A8M1NXE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
messages: Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.
messages: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
messages: Secreted

7955:fam83e
gene id: 7955:fam83e
uniprot id: E7EYL9
names: Similarity
messages: Belongs to the FAM83 family.

7955:pvalb5
gene id: 7955:pvalb5
uniprot id: Q804V9
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

7955:ren
gene id: 7955:ren
uniprot id: Q6YA65
names: Similarity
messages: Belongs to the peptidase A1 family.

7955:dgat2
gene id: 7955:dgat2
uniprot id: Q4V9F0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation (By similarity).
messages: Lipid droplet
messages: perinuclear region

7955:prdx1
gene id: 7955:prdx1
uniprot id: A2AWE1
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

7955:grk1b
gene id: 7955:grk1b
uniprot id: A0A8M9PXJ6
uniprot id: Q49HN0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

7955:ncbp2
gene id: 7955:ncbp2
uniprot id: Q8JGR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NCBP2 family.
messages: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (By simi…
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.
messages: Cytoplasm
messages: Nucleus

7955:si:dkey-84o3.7
gene id: 7955:si:dkey-84o3.7
uniprot id: E9QHZ3
names: Similarity
messages: Belongs to the peptidase S1C family.

7955:pimr48
gene id: 7955:pimr48
uniprot id: A0A8M6Z9P2
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

7955:mal
gene id: 7955:mal
uniprot id: Q567J3
names: Subcellular Location Annotation
messages: Membrane

7955:chia.2
gene id: 7955:chia.2
uniprot id: Q6P006
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

7955:gpam
gene id: 7955:gpam
uniprot id: E7F6M7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.
messages: Mitochondrion outer membrane

7955:hnrnpa3
gene id: 7955:hnrnpa3
uniprot id: A0A8M1P4F7
names: Subcellular Location Annotation
messages: Nucleus

7955:smtla
gene id: 7955:smtla
uniprot id: A0A8M9PFJ9
uniprot id: Q330L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

7955:gc
gene id: 7955:gc
uniprot id: A0A0R4ITN2
names: Function
names: Subcellular Location Annotation
messages: Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
messages: Secreted

7955:dmtn
gene id: 7955:dmtn
uniprot id: A0A8M2B209
uniprot id: A0A8M3BCX5
uniprot id: A0A8M9Q666
names: Subcellular Location Annotation
messages: Cytoplasm

7955:crabp1b
gene id: 7955:crabp1b
uniprot id: Q6IWJ1
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

7955:crebbpa
gene id: 7955:crebbpa
uniprot id: A0A0R4IPF2
uniprot id: A0A2R8Q4T2
uniprot id: A0A8M2B8L6
names: Subcellular Location Annotation
messages: Cytoplasm

7955:LOC100535674
gene id: 7955:LOC100535674
uniprot id: A0A8M9P953
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

7955:rhot1b
gene id: 7955:rhot1b
uniprot id: A0A8M2BDN6
uniprot id: A0A8M9PZT5
uniprot id: A0A8M9Q658
uniprot id: B3DI88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrion outer membrane

7955:tinagl1
gene id: 7955:tinagl1
uniprot id: A3KNG7
names: Similarity
messages: Belongs to the peptidase C1 family.

7955:wfikkn1
gene id: 7955:wfikkn1
uniprot id: Q6NUX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WFIKKN family.
messages: Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity).
messages: Secreted

7955:entpd1
gene id: 7955:entpd1
uniprot id: E7FG27
uniprot id: Q6DC46
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

7955:ccdc40
gene id: 7955:ccdc40
uniprot id: Q56A40
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CCDC40 family.
messages: Cytoplasm
messages: Defects are the cause of the lok phenotype, a phenotype related to primary ciliary dyskinesia (PCD). PCD is characterized by curly-tail down phenotype, laterality defects and pronephric cysts, but without defects in sensory cilia and without the presence of hydrocephalus.
messages: Expressed in tissues that contain motile cilia, including Kupffer's vesicle, the floorplate, the pronephric tubules and the otic vesicle.
messages: Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella.
messages: cilium

7955:dbt
gene id: 7955:dbt
uniprot id: Q5BKV3
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

7955:zgc:174259
gene id: 7955:zgc:174259
uniprot id: A0A8M9PKK0
uniprot id: A9JSZ7
names: Similarity
messages: Belongs to the serpin family.

7955:khdrbs1b
gene id: 7955:khdrbs1b
uniprot id: Q6NW62
names: Similarity
messages: Belongs to the KHDRBS family.

7955:LOC103911498
gene id: 7955:LOC103911498
uniprot id: A0A8M6YZY7
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

7955:bmi1b
gene id: 7955:bmi1b
uniprot id: Q7T3E6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of a PRC1-like complex. Homodimer. Interacts with cbx2 (By similarity).
messages: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of rnf2 (By similarity).
messages: Nucleus

7955:zgc:162730
gene id: 7955:zgc:162730
uniprot id: A0A8M1NCY5
uniprot id: A5D6V0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

7955:map7d2a
gene id: 7955:map7d2a
uniprot id: A0A2R8Q5N9
uniprot id: A0A8M3AS12
uniprot id: A0A8M3AS82
uniprot id: A0A8M3AZD4
uniprot id: A0A8M3B293
uniprot id: A0A8M3B296
uniprot id: A0A8M3B9F6
uniprot id: A0A8M9PWZ4
names: Similarity
messages: Belongs to the MAP7 family.

7955:slco1f4
gene id: 7955:slco1f4
uniprot id: A0A2R8QFF0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:sez6a
gene id: 7955:sez6a
uniprot id: A0A0R4IJM1
uniprot id: A0A8M1QL49
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:col27a1b
gene id: 7955:col27a1b
uniprot id: A0MSJ1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the fibrillar collagen family.
messages: May play a role during the calcification of cartilage and the transition of cartilage to bone (By similarity). Together with col27a1a, plays a role in development of the notochord and axial skeleton.
messages: The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity).
messages: Weakly expressed in the notochord from the 6 somite stage. Expressed throughout the notochord at 13 somites, then becomes restricted to the distal tip of the notochord by 24 hpf. Also expressed in head cartilages by 48 hpf.
messages: extracellular matrix

7955:si:dkey-96l17.6
gene id: 7955:si:dkey-96l17.6
uniprot id: A0A8M6YZ95
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:neo1a
gene id: 7955:neo1a
uniprot id: A0A0R4IIB3
uniprot id: A0A0R4IP15
uniprot id: A0A8M2BE14
uniprot id: A0A8M3AUJ2
uniprot id: A0A8M3AUL1
uniprot id: A0A8M3B4F0
uniprot id: A0A8M3BBA1
uniprot id: A0A8M6YZX3
uniprot id: A0A8M9PNJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. DCC family.
messages: Membrane

7955:sema6d
gene id: 7955:sema6d
uniprot id: B8JMB1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC110439311
gene id: 7955:LOC110439311
uniprot id: A0A8M9Q5M2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:si:dkey-33c9.6
gene id: 7955:si:dkey-33c9.6
uniprot id: E7F9C1
names: Subcellular Location Annotation
messages: Synapse
messages: axon
messages: dendritic spine

7955:grk6
gene id: 7955:grk6
uniprot id: E7F3T7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

7955:si:ch73-281i18.3
gene id: 7955:si:ch73-281i18.3
uniprot id: A0A0R4ICK5
names: Similarity
messages: Belongs to the MAP7 family.

7955:csgalnact1a
gene id: 7955:csgalnact1a
uniprot id: E7F6G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

7955:pcdh2g28
gene id: 7955:pcdh2g28
uniprot id: I6LD67
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

7955:anp32e
gene id: 7955:anp32e
uniprot id: Q6NUW5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ANP32 family.
messages: Component of a SWR1-like complex. Interacts with H2A.Z/H2AZ1 (By similarity).
messages: Cytoplasm
messages: Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state. Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis (By similarity).
messages: Nucleus
messages: Phosphorylated. The phosphorylation is nuclear localization signal (NLS)-dependent (By similarity).
messages: The H2A.Z-interacting domain (ZID) mediates a direct interaction with H2A.Z/H2AZ1.

7955:eva1bb
gene id: 7955:eva1bb
uniprot id: A9JRD7
names: Similarity
messages: Belongs to the EVA1 family.

7955:rnf40
gene id: 7955:rnf40
uniprot id: Q08CR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRE1 family.
messages: Nucleus

7955:ptk2aa
gene id: 7955:ptk2aa
uniprot id: Q7T2V4
names: Subcellular Location Annotation
messages: Cell membrane
messages: focal adhesion

7955:egflam
gene id: 7955:egflam
uniprot id: A0A8M3AZ99
uniprot id: A0A8M3B262
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:myadml2
gene id: 7955:myadml2
uniprot id: F1QNB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL family.
messages: Membrane

7955:gnptab
gene id: 7955:gnptab
uniprot id: A0A8M2BBZ0
uniprot id: Q5RGJ8
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the stealth family.
messages: Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Decreased mannose phosphorylation of lysosomal acid hydrolases, craniofacial and cardiac defects. Impaired development of pectoral fins and otic vesicles. Craniofacial defects are due to changes in the timing and localization of both type II collagen and sox9 expression, suggestive of an accelerated chondrocyte differentiation program. Increased level of active cathepsin K (ctsk) 3 days post-fertilization (dpf) because of abnormal processing and activation, leading to morphologic cartilage defects.
messages: Golgi apparatus membrane
messages: Hexamer of two alpha, two beta and two gamma (GNPTG) subunits; disulfide-linked. The alpha and/or the beta subunits of the enzyme constitute the catalytic subunits.
messages: Membrane
messages: Stealth proteins are part of a protein family that is conserved from bacteria to higher eukaryotes. Family members were first identified in microbes as proteins that help pathogens to elude the host innate immune system. Microbial stealth proteins are most likely involved in the biosynthesis of exopolysaccharides. Stealth proteins are predicted to function as hexose-1-phosphoryltransferases.
messages: The DMAP1-binding domain mediates substrate recognition. It specifically recognizes a conformation-dependent protein determinant present in acid hydrolases.
messages: The alpha- and beta-subunits are generated by a proteolytic cleavage by mbtps1 protease at the Gln-893-Asp-894 bond.

7955:amigo1
gene id: 7955:amigo1
uniprot id: A0A8M1QHZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. AMIGO family.
messages: Membrane

7955:gdf9
gene id: 7955:gdf9
uniprot id: Q5MD90
names: Similarity
messages: Belongs to the TGF-beta family.

7955:tmem248
gene id: 7955:tmem248
uniprot id: Q5BKX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM248 family.
messages: Membrane

7955:plxnb3
gene id: 7955:plxnb3
uniprot id: A0A8M3B4P7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:pitx1
gene id: 7955:pitx1
uniprot id: A0A8M9P3F1
uniprot id: A9Y0D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

7955:LOC100331510
gene id: 7955:LOC100331510
uniprot id: A0A8M1RKJ3
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

7955:ros1
gene id: 7955:ros1
uniprot id: A0A8M3AR79
uniprot id: A0A8N7TF47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

7955:si:dkey-17m8.1
gene id: 7955:si:dkey-17m8.1
uniprot id: A0A8M1Q1J1
uniprot id: A0A8M3AHZ5
uniprot id: A0A8M6YSV2
names: Similarity
messages: Belongs to the JIP scaffold family.

7955:casq1b
gene id: 7955:casq1b
uniprot id: F6P0J3
uniprot id: Q08BX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

7955:vps33a
gene id: 7955:vps33a
uniprot id: A0A0R4ID82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

7955:LOC799227
gene id: 7955:LOC799227
uniprot id: A0A8M1Q1S9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:ralba
gene id: 7955:ralba
uniprot id: Q6DC92
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

7955:gng2
gene id: 7955:gng2
uniprot id: Q15KE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

7955:celsr1a
gene id: 7955:celsr1a
uniprot id: A0A8M3ARK0
uniprot id: A0A8M3ARU0
uniprot id: A0A8M3B933
uniprot id: F1R9W4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor that may have an important role in cell/cell signaling during nervous system formation.

7955:cacna1sa
gene id: 7955:cacna1sa
uniprot id: A0A8M2BFL7
uniprot id: C0LU14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

7955:si:dkey-60a16.1
gene id: 7955:si:dkey-60a16.1
uniprot id: A0A8M3ALC0
uniprot id: E7F214
names: Similarity
messages: Belongs to the HARBI1 family.

7955:chrm5a
gene id: 7955:chrm5a
uniprot id: Q7T286
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

7955:stat5a
gene id: 7955:stat5a
uniprot id: Q68SP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

7955:tmem206
gene id: 7955:tmem206
uniprot id: X1WG42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proton-activated chloride channel family.
messages: Cell membrane
messages: Membrane

7955:ihha
gene id: 7955:ihha
uniprot id: A3KNS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

7955:adgrd1
gene id: 7955:adgrd1
uniprot id: A0A8M9PR40
names: Subcellular Location Annotation
messages: Membrane

7955:slc6a1a
gene id: 7955:slc6a1a
uniprot id: F1QUY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:crygm2d2
gene id: 7955:crygm2d2
uniprot id: Q15I86
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:chordc1b
gene id: 7955:chordc1b
uniprot id: Q7T3F7
names: Function
messages: Regulates centrosome duplication.

7955:uts2b
gene id: 7955:uts2b
uniprot id: A0A8M9QLJ3
uniprot id: B3DFZ3
uniprot id: Q7ZZY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted
messages: Urotensin is found in the teleost caudal neurosecretory system. It has a suggested role in osmoregulation and as a corticotropin-releasing factor (By similarity).

7955:tspan12
gene id: 7955:tspan12
uniprot id: A0A8M3AR77
uniprot id: Q7T2G0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:snx19a
gene id: 7955:snx19a
uniprot id: B3DJX2
names: Similarity
messages: Belongs to the sorting nexin family.

7955:scube3
gene id: 7955:scube3
uniprot id: A0A8M9PKI0
uniprot id: F1R0I7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:hlx1
gene id: 7955:hlx1
uniprot id: A0A8M2BHM6
uniprot id: A0A8M3B4D8
uniprot id: Q6NY96
names: Subcellular Location Annotation
messages: Nucleus

7955:stmn3
gene id: 7955:stmn3
uniprot id: E7FFU5
names: Similarity
messages: Belongs to the stathmin family.

7955:LOC101882464
gene id: 7955:LOC101882464
uniprot id: A0A8M9Q9T1
names: Similarity
messages: Belongs to the HARBI1 family.

7955:si:ch211-225b11.1
gene id: 7955:si:ch211-225b11.1
uniprot id: A0A8M9Q3H3
uniprot id: A4QNW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:inha
gene id: 7955:inha
uniprot id: Q1LYE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
messages: Secreted

7955:pou2f3
gene id: 7955:pou2f3
uniprot id: A0A8M2BJD9
uniprot id: A1L1Z1
uniprot id: F6NVR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus

7955:pah
gene id: 7955:pah
uniprot id: Q6PHI7
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

7955:hpda
gene id: 7955:hpda
uniprot id: F1Q6E1
uniprot id: Q7ZUY6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

7955:vgll4a
gene id: 7955:vgll4a
uniprot id: F1RCR5
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

7955:kiz
gene id: 7955:kiz
uniprot id: A0A2R8PWB6
uniprot id: A5D8S0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kizuna family.
messages: Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.
messages: centrosome
messages: cilium basal body

7955:si:dkey-4c23.3
gene id: 7955:si:dkey-4c23.3
uniprot id: A0A8M9PST4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:nupr1
gene id: 7955:nupr1
uniprot id: E9QCY4
names: Similarity
messages: Belongs to the NUPR family.

7955:LOC799072
gene id: 7955:LOC799072
uniprot id: A0A8M9PUB9
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

7955:mmachc
gene id: 7955:mmachc
uniprot id: A0A8M9PSN9
uniprot id: Q5RFU5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MMACHC family.
messages: Can utilize both FAD and FMN.
messages: Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate. Cyanocobalamin constitutes the inactive form of vitamin B12 introduced from the diet, and is converted into the active cofactors methylcobalamin (MeCbl) involved in methionine biosynthesis, and 5'-deoxyadenosylcobalamin (AdoCbl) involved in the TCA cycle. Forms a complex with the lysosomal transporter ABCD4 and its chaperone LMBRD1, to transport cobalamin across the lysosomal membrane into the cytosol. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine. Also acts as a glutathione transferase by catalyzing the dealkylation of the alkylcob(III)alamins MeCbl and AdoCbl, using the thiolate of glutathione for nucleophilic displacement to generate cob(I)alamin and the corresponding glutathione thioether. The conversion of incoming MeCbl or AdoCbl into a common intermediate cob(I)alamin is necessary to meet the cellular needs for both cofactors. Cysteine and homocysteine cannot substitute for glutathione in this reaction.
messages: Monomer in the absence of bound substrate. Homodimer; dimerization is triggered by binding to FMN or adenosylcobalamin. Heterodimer with MMADHC.
messages: cytosol

7955:tgfa
gene id: 7955:tgfa
uniprot id: A0A8M2BDJ4
uniprot id: A0A8M3ATI5
uniprot id: A0A8M3B0K7
uniprot id: A0A8M3BAH4
uniprot id: Q7T011
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:crebl2
gene id: 7955:crebl2
uniprot id: Q642H2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Nucleus
messages: Probable regulator of creb1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle (By similarity).

7955:napaa
gene id: 7955:napaa
uniprot id: A4FVI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

7955:erap1a
gene id: 7955:erap1a
uniprot id: A0A8M2B1Z9
uniprot id: A0A8M3AWF2
uniprot id: A0A8M3B5Z1
uniprot id: A0A8M9Q695
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

7955:kif14
gene id: 7955:kif14
uniprot id: F1Q554
uniprot id: Q1LW14
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:tmem189
gene id: 7955:tmem189
uniprot id: Q5XJL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase CarF family.
messages: Membrane

7955:LOC100333355
gene id: 7955:LOC100333355
uniprot id: A0A8M9PTD4
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:csrnp1b
gene id: 7955:csrnp1b
uniprot id: E9QH67
uniprot id: Q6PFK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

7955:tbx3a
gene id: 7955:tbx3a
uniprot id: B8JKS6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7955:si:dkeyp-11e3.1
gene id: 7955:si:dkeyp-11e3.1
uniprot id: A0A8M9QGR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: Nucleus

7955:eya2
gene id: 7955:eya2
uniprot id: Q66HX1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

7955:myoz1b
gene id: 7955:myoz1b
uniprot id: A0A8M6Z1X3
uniprot id: Q6DHF0
names: Similarity
messages: Belongs to the myozenin family.

7955:kcnj16
gene id: 7955:kcnj16
uniprot id: A0A8M3B7L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

7955:abi1a
gene id: 7955:abi1a
uniprot id: A0A2R8Q1F3
uniprot id: A0A2R8QEN6
uniprot id: A0A8M2B9B3
uniprot id: A0A8M2B9D2
uniprot id: A0A8M3AND6
uniprot id: A0A8M3AP19
uniprot id: A0A8M3B6H8
uniprot id: F1R187
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

7955:phactr1
gene id: 7955:phactr1
uniprot id: A0A8M1P9M3
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

7955:rasgrf2b
gene id: 7955:rasgrf2b
uniprot id: A2CEA7
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Functions as a calcium-regulated nucleotide exchange factor activating both Ras and rac1 through the exchange of bound GDP for GTP. May function in synaptic plasticity.
messages: The DH (DBL-homology) domain is required for rac1 activation.
messages: The IQ domain is dispensable for the Ras-GEF activity.
messages: The Ras-GEF domain and the N-terminal Ras-GEF domain mediate Ras activation.

7955:ddx31
gene id: 7955:ddx31
uniprot id: A2BFD2
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

7955:adam8b
gene id: 7955:adam8b
uniprot id: A0A8M3AY73
uniprot id: E7F6J8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:acsf2
gene id: 7955:acsf2
uniprot id: F1R1C0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

7955:dgkza
gene id: 7955:dgkza
uniprot id: A0A1D5NSE1
uniprot id: A0A8M1QKR7
uniprot id: A0A8M2BGB6
uniprot id: A0A8M2BGE2
uniprot id: A0A8M2BGZ7
uniprot id: A0A8M3B4A5
uniprot id: A0A8M9Q2N7
uniprot id: A0A8M9Q8U0
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

7955:LOC101883382
gene id: 7955:LOC101883382
uniprot id: A0A8M2BC10
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:dgkb
gene id: 7955:dgkb
uniprot id: A0A8M9P7J8
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

7955:pdgfd
gene id: 7955:pdgfd
uniprot id: A0A8M1RFF2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:tmc2a
gene id: 7955:tmc2a
uniprot id: E7FFT2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TMC family.
messages: Cell membrane
messages: Expressed in the nascent hair cells of the developing ear as early as 1 day post fertilization (dpf), and expression in the inner ear continues throughout development. Expression is restricted to the upper hair cell layer of the neuroepithelium at 5 dpf.
messages: In adults, expression is restricted to the hair cells of inner ear and lateral line organ. Expressed at higher levels in the larval inner ear than in the lateral-line neuromasts.
messages: Interacts (via N-terminus) with both isoforms CD1 and CD3 of PCDH15A (via cytoplasmic domain); this interaction is required for mechanotransduction of the hair cells and correct localization of PCDH15A in hair bundles of the hair cells.
messages: Probable ion channel required for the normal function of hair cells (By similarity). Component of the hair cell's mechanotransduction (MET) machinery. Involved in mechanosensitive responses of the hair cells (PubMed:25114259).

7955:si:ch211-254c8.3
gene id: 7955:si:ch211-254c8.3
uniprot id: A0A8M9PKE5
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:si:ch211-246m6.5
gene id: 7955:si:ch211-246m6.5
uniprot id: A0A8M3B5G3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:wu:fa11c10
gene id: 7955:wu:fa11c10
uniprot id: A0A8M3B612
names: Similarity
messages: Belongs to the FAM110 family.

7955:foxe3
gene id: 7955:foxe3
uniprot id: B0UXI3
names: Subcellular Location Annotation
messages: Nucleus

7955:si:ch211-168f7.5
gene id: 7955:si:ch211-168f7.5
uniprot id: E7F271
names: Similarity
messages: Belongs to the dapper family.

7955:adnp2a
gene id: 7955:adnp2a
uniprot id: A4QP16
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed from the 1-cell stage, before the onset of zygotic expression, then, during gastrulation, at 6 hours post-fertilization (hpf), expression is absent, and at 11-12 hpf, coincident with segmentation, expression returns until 72 hpf.
messages: May be involved in transcriptional regulation (PubMed:23071114). Required for progression through late erythroid differentiation (PubMed:23071114). May be involved in vasculogenesis (PubMed:23071114).
messages: Morpholino knockdown has no effect on overall morphology, and at the onset of blood circulation at 24 hours post-fertilization (hpf), blood cells are present, however between 33 and 48 hpf, blood cells are absent, and embryos develop cardiac edema (PubMed:23071114). Hemoglobin undetectable (PubMed:23071114). Some embryos recovered blood circulation at day 4 after knockdown, whereas others became severely edematous at day 4-5 and died by about 7 days (PubMed:23071114). At 28 and 48 hpf, expression of band3 almost abolished; embryonic alpha-globin1 also significantly reduced at 28 hpf (PubMed:23071114).
messages: Nucleus

7955:ldhbb
gene id: 7955:ldhbb
uniprot id: A0A8M2BIE4
uniprot id: B2GRW6
uniprot id: Q6DGK2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Cytoplasm
messages: Homotetramer.

7955:chpt1
gene id: 7955:chpt1
uniprot id: Q7ZW02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes the final step of de novo phosphatidylcholine (PC) synthesis, i.e. the transfer of choline phosphate from CDP-choline to the free hydroxyl of a diacylglycerol (DAG), producing a PC. It thereby plays a central role in the formation and maintenance of vesicular membranes.
messages: Golgi apparatus membrane

7955:si:dkey-85k7.12
gene id: 7955:si:dkey-85k7.12
uniprot id: A0A8M2BJH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

7955:adgrl2a
gene id: 7955:adgrl2a
uniprot id: A0A2R8QK81
uniprot id: A0A2R8QN46
uniprot id: A0A8M2BKM2
uniprot id: A0A8M3AXD8
uniprot id: A0A8M3AXE4
uniprot id: A0A8M3AXG2
uniprot id: A0A8M3B3W7
uniprot id: A0A8M3B6R1
uniprot id: A0A8M3BDJ0
uniprot id: A0A8M9PV67
uniprot id: A0A8M9Q7G8
uniprot id: A0A8M9Q7H1
uniprot id: A0A8M9Q7H6
uniprot id: A0A8M9Q7H9
uniprot id: A0A8M9QDD0
uniprot id: A0A8M9QDD5
uniprot id: A0A8M9QDE0
uniprot id: A0A8M9QHW5
uniprot id: A0A8M9QHX3
uniprot id: A0A8M9QHX6
uniprot id: A0A8M9QLT7
uniprot id: A0A8M9QLT9
uniprot id: A0A8M9QLU5
uniprot id: F1QPV2
names: Subcellular Location Annotation
messages: Membrane

7955:ca4b
gene id: 7955:ca4b
uniprot id: A0A8M1NSW5
uniprot id: Q6DBS1
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

7955:fas
gene id: 7955:fas
uniprot id: F1QG24
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

7955:tor4ab
gene id: 7955:tor4ab
uniprot id: A7MBW1
names: Similarity
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.

7955:zgc:173594
gene id: 7955:zgc:173594
uniprot id: A7YYB6
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

7955:taar10a
gene id: 7955:taar10a
uniprot id: Q5QNP6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:ddx28
gene id: 7955:ddx28
uniprot id: Q08BL1
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

7955:kdelc1
gene id: 7955:kdelc1
uniprot id: Q7ZVE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KDELC family.
messages: Endoplasmic reticulum lumen
messages: Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C. Can also catalyze the transfer of xylose from UDP-xylose but less efficiently.

7955:otpa
gene id: 7955:otpa
uniprot id: B3DGA5
uniprot id: F6NUE7
names: Subcellular Location Annotation
messages: Nucleus

7955:LOC560917
gene id: 7955:LOC560917
uniprot id: A0A8M9QCV4
names: Similarity
messages: Belongs to the peptidase S1C family.

7955:tpmt.1
gene id: 7955:tpmt.1
uniprot id: B8JKP3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.

7955:nkx3-1
gene id: 7955:nkx3-1
uniprot id: A0A8N7TAH9
names: Subcellular Location Annotation
messages: Nucleus

7955:slc25a4
gene id: 7955:slc25a4
uniprot id: Q6NX10
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

7955:foxd5
gene id: 7955:foxd5
uniprot id: O73784
names: Subcellular Location Annotation
messages: Nucleus

7955:fezf1
gene id: 7955:fezf1
uniprot id: Q25C93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Transcription repressor. Involved in the development of the forebrain region (By similarity).

7955:cldn11b
gene id: 7955:cldn11b
uniprot id: A4QNU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

7955:cdc42l
gene id: 7955:cdc42l
uniprot id: Q7ZUQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Membrane
messages: Midbody
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.

7955:pcxa
gene id: 7955:pcxa
uniprot id: A0A0R4IFJ4
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

7955:gnl2
gene id: 7955:gnl2
uniprot id: Q7SZQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

7955:tm4sf5
gene id: 7955:tm4sf5
uniprot id: Q6DHT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

7955:mrpl47
gene id: 7955:mrpl47
uniprot id: E7F6A5
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

7955:tgm1
gene id: 7955:tgm1
uniprot id: A0A8M3AV10
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

7955:sorcs3
gene id: 7955:sorcs3
uniprot id: A0A8M9Q0Q0
names: Similarity
messages: Belongs to the VPS10-related sortilin family. SORCS subfamily.

7955:panx1b
gene id: 7955:panx1b
uniprot id: F1QSR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

7955:cnn1b
gene id: 7955:cnn1b
uniprot id: A0A0R4IGU0
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

7955:hoxc11a
gene id: 7955:hoxc11a
uniprot id: B2GQI4
uniprot id: Q58EL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

7955:zw10
gene id: 7955:zw10
uniprot id: Q803G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZW10 family.
messages: kinetochore

7955:ndufa11
gene id: 7955:ndufa11
uniprot id: Q7SXE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFA11 subunit family.
messages: Mitochondrion inner membrane

7955:edn1
gene id: 7955:edn1
uniprot id: Q9I8G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

7955:timp4.1
gene id: 7955:timp4.1
uniprot id: A0A2R8Q0U9
names: Similarity
messages: Belongs to the protease inhibitor I35 (TIMP) family.

7955:si:ch211-114l13.7
gene id: 7955:si:ch211-114l13.7
uniprot id: A5PMF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 25 family.
messages: Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of type I collagen. By acting on collagen glycosylation, facilitates the formation of collagen triple helix.
messages: Endoplasmic reticulum lumen

7955:zgc:85932
gene id: 7955:zgc:85932
uniprot id: A0A0R4IX46
uniprot id: A0A8M9QLB9
uniprot id: A0A8M9QPT0
uniprot id: Q6NW69
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:zgc:153146
gene id: 7955:zgc:153146
uniprot id: F1QA34
uniprot id: Q0P4C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP96 family.
messages: centrosome

7955:LOC402879
gene id: 7955:LOC402879
uniprot id: A0A8M2BIE5
names: Subcellular Location Annotation
messages: Membrane

7955:olfml3a
gene id: 7955:olfml3a
uniprot id: Q0P3W2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OLFML3 family.
messages: Secreted
messages: Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity).

7955:rnps1
gene id: 7955:rnps1
uniprot id: Q6PG31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the splicing factor SR family.
messages: Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Putative component of the spliceosome which enhances the formation of the ATP-dependent A complex of the spliceosome. May participate in mRNA 3'-end cleavage. Also mediates increase of mRNA abundance and translational efficiency (By similarity).
messages: Component of the active spliceosome.
messages: Cytoplasm
messages: Nucleus
messages: Nucleus speckle

7955:uhrf1
gene id: 7955:uhrf1
uniprot id: E7EZF3
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Embryos have a small head, eyes, jaw and an underdeveloped gut. Moreover many mutants display diminished yolk consumption and uninflated swim bladder as well as embryonic lethality. DNA methylation is impaired during embryogenesis and embryos display defects in lens development and maintenance. No fertility defects are noted for heterozygous animals.
messages: Expressed in proliferating tissues. Highly expressed 24-48 hours after fertilization (hpf) in rapidly proliferating tissues, including the tectum, retina and brachial arches. Preferentially expressed in the liver bud and expression is maintained in the fully developed liver. Also expressed in the proximal gut. In adult, the highest expression is detected in testis.
messages: Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits dnmt1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins. However, it is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo (By similarity). Required for pregastrula and lens development.
messages: Nucleus
messages: Phosphorylation at Ser-649 is required for gastrulation.
messages: The RING finger is required for ubiquitin ligase activity.
messages: The YDG domain (also named SRA domain) specifically recognizes and binds hemimethylated DNA at replication forks (DNA that is only methylated on the mother strand of replicating DNA).
messages: The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3).

7955:mfsd6b
gene id: 7955:mfsd6b
uniprot id: A0A8M1P4K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

7955:kif16ba
gene id: 7955:kif16ba
uniprot id: A0A8M3AVN1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:dusp7
gene id: 7955:dusp7
uniprot id: A0A0R4IE73
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

7955:ssbp1
gene id: 7955:ssbp1
uniprot id: B8A5I7
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA) (By similarity). May be required to maintain the copy number of mitochondrial DNA (mtDNA) and play a crucial role during mtDNA replication (PubMed:31550240). Required for retinal ganglion cell differentiation and retinal integrity (PubMed:31298765).
messages: Mitochondrion
messages: Morpholino-induced knockdown results in reduction in optic nerve size and mitochondrial depletion (PubMed:31550240, PubMed:31298765). Strongly reduced expression of the developmental regulator genes isl1 and atoh7 in retinal ganglion cell (RGC) precursors (PubMed:31298765). Nonphotoreceptor cells, both in the ganglion cell layer and in the inner nuclear layer, display compromised neuronal specification, whereas cell numbers in both layers are unaltered (PubMed:31298765).
messages: mitochondrion nucleoid

7955:smug1
gene id: 7955:smug1
uniprot id: A0A0G2KZ26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.
messages: Nucleus

7955:zgc:86586
gene id: 7955:zgc:86586
uniprot id: A0A8M2BEV7
uniprot id: Q8UWM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:fen1
gene id: 7955:fen1
uniprot id: Q6TNU4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. Three molecules of fen1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Mitochondrion
messages: Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

7955:tmcc1a
gene id: 7955:tmcc1a
uniprot id: A0A8M3AVM2
uniprot id: A0A8M9PRQ1
uniprot id: E7FBA2
names: Similarity
messages: Belongs to the TEX28 family.

7955:disp1
gene id: 7955:disp1
uniprot id: Q6R5J2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dispatched family.
messages: Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (PubMed:15110707). Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity).
messages: Interacts with SHH; via the cholesterol anchor of the dually lipid-modified SHH (ShhNp).
messages: Membrane
messages: Ubiquitously expressed throughout the embryo from fertilization onward. Accumulates at higher levels in the notochord, the ventral floor of the brain as well as dorsal and ventral margins of the myotome.

7955:LOC110437829
gene id: 7955:LOC110437829
uniprot id: A0A8M9P5N3
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:efhc1
gene id: 7955:efhc1
uniprot id: Q7T2F1
names: Subcellular Location Annotation
messages: cilium axoneme

7955:p2ry11
gene id: 7955:p2ry11
uniprot id: A0A8M1P2Q4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:prpsap2
gene id: 7955:prpsap2
uniprot id: A0A8M2BBD0
uniprot id: Q803V2
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

7955:cox5aa
gene id: 7955:cox5aa
uniprot id: Q4VBU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

7955:acot21
gene id: 7955:acot21
uniprot id: A0A8N7T759
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

7955:anapc16
gene id: 7955:anapc16
uniprot id: A0A8M2BKA0
uniprot id: Q561X1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC16 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Cytoplasm
messages: Nucleus
messages: kinetochore

7955:zgc:195023
gene id: 7955:zgc:195023
uniprot id: B3DJJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

7955:ube2ia
gene id: 7955:ube2ia
uniprot id: A0A8M9P459
uniprot id: Q9DDJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis.
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Forms a tight complex with rangap1 and ranbp2 (By similarity). Interacts with vsx1.
messages: Nucleus

7955:gpr146
gene id: 7955:gpr146
uniprot id: A0JMI2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:mknk1
gene id: 7955:mknk1
uniprot id: A0A8M2B1Y9
uniprot id: A0A8M2B223
uniprot id: A0A8M2B2B7
uniprot id: F1QJV2
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:rtn2a
gene id: 7955:rtn2a
uniprot id: A0A8M2B494
uniprot id: A0A8M2B4B6
uniprot id: Q4G5K8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:si:ch73-92i20.1
gene id: 7955:si:ch73-92i20.1
uniprot id: A0A8M1PUK4
names: Similarity
messages: Belongs to the GAB family.

7955:slc9a3.2
gene id: 7955:slc9a3.2
uniprot id: A0A8M3ASE1
uniprot id: A9XP97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Membrane
messages: Recycling endosome membrane

7955:cyp3a65
gene id: 7955:cyp3a65
uniprot id: Q32LT1
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:LOC100151419
gene id: 7955:LOC100151419
uniprot id: A0A8M1QKQ6
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

7955:cdadc1
gene id: 7955:cdadc1
uniprot id: A0A8M2BIB1
uniprot id: F8W4G5
uniprot id: Q5U3U4
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Catalyzes the deamination of cytidine and deoxycytidine into uridine and deoxyuridine, respectively.

7955:cd74a
gene id: 7955:cd74a
uniprot id: Q9PUT2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:med1
gene id: 7955:med1
uniprot id: A0A8M9PXG2
uniprot id: A0A8M9Q9D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

7955:si:ch73-368j24.11
gene id: 7955:si:ch73-368j24.11
uniprot id: A0A140LFZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

7955:brinp1
gene id: 7955:brinp1
uniprot id: E7FFP8
names: Similarity
messages: Belongs to the BRINP family.

7955:spire1b
gene id: 7955:spire1b
uniprot id: A0A8M9NZX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spire family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytoskeleton

7955:hacl1
gene id: 7955:hacl1
uniprot id: Q6NYI5
names: Similarity
messages: Belongs to the TPP enzyme family.

7955:vps41
gene id: 7955:vps41
uniprot id: E7F590
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS41 family.
messages: Core component of at least two putative endosomal tethering complexes, the homotypic fusion and vacuole protein sorting (HOPS) complex and the class C core vacuole/endosome tethering (CORVET) complex.
messages: Disruption of the gene results in melanocyte pigmentation defects, decreased body length, and bladder defects associated with abnormalities in surfactant production or distribution, consistent with abnormalities of lysosome-related organelles. Mutant animals also have defects in the optokinetic response and eye movement control system, suggesting cerebellar dysfunction. Microglia from mutant fish show morphologic abnormalities, with larger or more numerous lysosomal compartments and increased expression of acidic lysosomal markers compared to controls.
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: clathrin-coated vesicle
messages: cytosol
messages: trans-Golgi network

7955:eve1
gene id: 7955:eve1
uniprot id: F1R6B2
uniprot id: Q90265
names: Subcellular Location Annotation
messages: Nucleus

7955:si:ch211-71m22.5
gene id: 7955:si:ch211-71m22.5
uniprot id: A0A2R8S0G3
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

7955:zdhhc5b
gene id: 7955:zdhhc5b
uniprot id: A0A8M2BH23
uniprot id: A0A8M3AI50
uniprot id: A0A8M3ASA6
uniprot id: E7FBS9
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Cell membrane
messages: Membrane
messages: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes.
messages: Probably maternally supplied, the zygotic expression is detected early during development at the 512-cell stage.
messages: The DHHC domain is required for palmitoyltransferase activity.

7955:iars
gene id: 7955:iars
uniprot id: A0A8N7UZX0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

7955:gpr184
gene id: 7955:gpr184
uniprot id: A0A0R4IWV6
uniprot id: Q08CU6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:foxp1a
gene id: 7955:foxp1a
uniprot id: A0A2R8Q1R5
uniprot id: A0A8M2B938
uniprot id: A0A8M9P554
uniprot id: A0A8M9PF34
uniprot id: F1Q4T2
names: Subcellular Location Annotation
messages: Nucleus

7955:tomm20a
gene id: 7955:tomm20a
uniprot id: Q6PC05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

7955:zgc:174260
gene id: 7955:zgc:174260
uniprot id: A0A8M1NHL5
uniprot id: A8KBW0
names: Similarity
messages: Belongs to the serpin family.

7955:kcnk10b
gene id: 7955:kcnk10b
uniprot id: A0A286Y8D0
uniprot id: A0A8M2BH55
uniprot id: C3VPM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

7955:babam1
gene id: 7955:babam1
uniprot id: Q6AXK4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM1 family.
messages: Component of the ARISC complex, at least composed of uimc1/rap80, abraxas1, brcc3/brcc36, babam2 and babam1/nba1. Component of the BRCA1-A complex, at least composed of bard1, uimc1/rap80, abraxas1, brcc3/brcc36, babam2 and babam1/nba1. In the BRCA1-A complex, interacts directly with abraxas1 and babam2. Component of the BRISC complex, at least composed of abraxas2, brcc3/brcc36, babam2 and babam1/nba1 (PubMed:26344097).
messages: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites. The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DNA double-strand breaks (DSBs). Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:26344097). In these 2 complexes, it is probably required to maintain the stability of babam2 and help the 'Lys-63'-linked deubiquitinase activity mediated by brcc3/brcc36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating numa1.
messages: Cytoplasm
messages: Nucleus
messages: The VWFA-like region is similar to the VWFA domain. Its presence reveals similarities between the structure of the 19S proteasome and the BRCA1-A complexes.
messages: There is no annotated ortholog of the vertebrate gene BRCA1 in the current zebrafish genome (PubMed:23594743). Therefore, mentions of brca1 in relevant curated zebrafish entries have been removed. However some complexes, conserved widely across species, have BRCA1 in their name and so have been left unchanged.

7955:smpd3
gene id: 7955:smpd3
uniprot id: B1B5D9
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

7955:lcat
gene id: 7955:lcat
uniprot id: A0A8M1P7R5
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

7955:reep3a
gene id: 7955:reep3a
uniprot id: Q2YDS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

7955:zgc:194189
gene id: 7955:zgc:194189
uniprot id: B3DHP4
names: Subcellular Location Annotation
messages: Nucleus

7955:timm8b
gene id: 7955:timm8b
uniprot id: B3DGI9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

7955:osbpl3a
gene id: 7955:osbpl3a
uniprot id: Q1LW95
uniprot id: Q66L55
names: Similarity
messages: Belongs to the OSBP family.

7955:si:ch211-161n3.3
gene id: 7955:si:ch211-161n3.3
uniprot id: A0A8M9PUV5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:ush2a
gene id: 7955:ush2a
uniprot id: A0A8M3ARH7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:vps26a
gene id: 7955:vps26a
uniprot id: Q6TNP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity).
messages: Belongs to the VPS26 family.
messages: Component of the heterotrimeric retromer cargo-selective complex (CSC) which is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants (By similarity).
messages: Cytoplasm
messages: Early endosome
messages: Endosome membrane

7955:il1rap
gene id: 7955:il1rap
uniprot id: A0A8M9PLW3
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

7955:zp2.1
gene id: 7955:zp2.1
uniprot id: F1R003
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:tnnt3a
gene id: 7955:tnnt3a
uniprot id: A0A8M2BAI0
uniprot id: Q9I8U9
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

7955:ascl1a
gene id: 7955:ascl1a
uniprot id: Q90259
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: First detected at 12 hours post-fertilization (hpf), increasing over the next 24 hours, then decreasing between 48 and 72 hours. Not detected in adult.
messages: In pituitary absent (pia) mutants, adenohypophyseal cells fail to express hormone genes and some become apoptotic.
messages: In the 24 hours embryo, expressed in the dorsal hindbrain in two bilaterally symmetrical lines of cells marking the boundary between the alar and basal plates, and ventrally in rhombomere 1 near the floor plate. Also expressed in embryonic adenohypophysis, telencephalon, diencephalon, epiphysis, ventral tegmentum, neural retina and spinal cord, in discrete regions distinct from those expressing ascl1b. In the 30 hours embryo, hindbrain expression is in stripes adjacent to rhombomere boundaries.
messages: Nucleus
messages: Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter (By similarity). Involved in neurogenesis. Required for the development of neurons in the epiphysis, acting partially redundantly with neurog1 and downstream of flh. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. Also involved in pituitary development; required cell-autonomously in adenohypophyseal cells for endocrine differentiation and for survival of a subset of cells.

7955:LOC108178999
gene id: 7955:LOC108178999
uniprot id: Q5U374
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPII-coated vesicle
messages: Component of the BCR(KLHL12) E3 ubiquitin ligase complex.
messages: Expressed ubiquitously throughout development.
messages: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division (By similarity). Negatively regulates the Wnt signaling pathway, possibly via the targeted ubiquitination and subsequent proteolysis of dvl2 and dvl3 (PubMed:16547521). Regulates convergent-extension movements during early embryonic development (PubMed:16547521).

7955:dstyk
gene id: 7955:dstyk
uniprot id: Q4VSN1
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm
messages: May act as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death (By similarity). Plays a role in the embryonic development.
messages: Morpholino knockdown of the protein causes growth retardation, as evidenced by small fins, abnormal morphogenesis of the tail, and loss of heartbeat. Pericardial effusion was evident in 5-day-old morphant larvae.

7955:six6a
gene id: 7955:six6a
uniprot id: Q7T3G8
names: Subcellular Location Annotation
messages: Nucleus

7955:phox2ba
gene id: 7955:phox2ba
uniprot id: B8A4X8
names: Subcellular Location Annotation
messages: Nucleus

7955:tmem123
gene id: 7955:tmem123
uniprot id: A0A8M9PW00
uniprot id: A0A8M9Q710
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

7955:c3a.3
gene id: 7955:c3a.3
uniprot id: A0A8M9PID4
uniprot id: F1QX13
names: Subcellular Location Annotation
messages: Secreted

7955:chmp4c
gene id: 7955:chmp4c
uniprot id: Q568Q1
names: Similarity
messages: Belongs to the SNF7 family.

7955:tnfsf12
gene id: 7955:tnfsf12
uniprot id: Q08BZ0
names: Similarity
messages: Belongs to the tumor necrosis factor family.

7955:rfc1
gene id: 7955:rfc1
uniprot id: F1Q5P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the activator 1 large subunit family.
messages: Nucleus

7955:mfsd6l
gene id: 7955:mfsd6l
uniprot id: Q6DBX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

7955:tdrd6
gene id: 7955:tdrd6
uniprot id: F1R237
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Expressed in the ovary, where it localizes to nuage and to the Balbiani body (PubMed:30086300). Maternally provided and localized to the germ plasm in 4-cell stage embryos (PubMed:30086300). 24 hours post-fertilization, restricted to primordial germ cells, where it localizes to nuage (a peri-nuclear protein-RNA aggregate that associates closely with mitochondria) (PubMed:30086300).
messages: Interacts (via Tudor domain) with buc (when dimethylated on arginine residues); and may be responsible for recruitment of different protein complexes to germ plasm.
messages: Knockout oocytes exhibit significant defects in germ cell development, leading to reduction in primordial germ cell number in the offspring, irrespective of the genotype of the father (PubMed:30086300). Barely affects piRNA populations (PubMed:30086300).
messages: The tudor domains recognize and bind to proteins with dimethylated arginine or lysine residues (Probable). Plays an important role in the protein functions through its direct binding to the target proteins (Probable).
messages: Tudor domain-containing protein involved in germ cell development, more specifically the formation of chromatoid body (during spermiogenesis), Balbiani body (during oogenesis), germ plasm (upon fertilization), and for proper miRNA expression and spliceosome maturation (By similarity) (PubMed:30086300). Required for Balbiani body and germ plasm formation and mobility through interaction with dimethylated arginines in the prion-like protein Bucky ball (buc) (PubMed:30086300). Coordinates transcript deposition into future primordial germ cells (PubMed:30086300). Interacts with known germ plasm mRNAs such as vasa, dazl, nanos3 and hook2 (PubMed:30086300).

7955:zgc:136872
gene id: 7955:zgc:136872
uniprot id: F1QW40
uniprot id: Q1RLS9
names: Similarity
messages: Belongs to the peptidase C2 family.

7955:adrb2b
gene id: 7955:adrb2b
uniprot id: A0A8M9PI29
uniprot id: A4QNV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:stpg1
gene id: 7955:stpg1
uniprot id: A0A0R4IZT8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7955:gtf2f2a
gene id: 7955:gtf2f2a
uniprot id: A7MCQ3
uniprot id: B8JHR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF beta subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.

7955:exoc4
gene id: 7955:exoc4
uniprot id: Q5TYY2
names: Function
names: Similarity
messages: Belongs to the SEC8 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

7955:si:dkey-46g23.2
gene id: 7955:si:dkey-46g23.2
uniprot id: A0A8M9Q2V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

7955:mycla
gene id: 7955:mycla
uniprot id: Q9PSI9
names: Developmental Stage
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with max (By similarity).
messages: Most abundant during early rapid cleavage, blastulation, and gastrulation. Reduced levels from time of establishment of the body plan (around 12 hours) and thereafter.
messages: Nucleus
messages: Uterus.

7955:pus3
gene id: 7955:pus3
uniprot id: Q7ZW97
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

7955:cox7a3
gene id: 7955:cox7a3
uniprot id: Q7SXI1
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

7955:htra3a
gene id: 7955:htra3a
uniprot id: Q6DBR1
names: Similarity
messages: Belongs to the peptidase S1C family.

7955:hoxb1a
gene id: 7955:hoxb1a
uniprot id: B3DHZ4
names: Subcellular Location Annotation
messages: Nucleus

7955:fbxo25
gene id: 7955:fbxo25
uniprot id: A0A8M9PT00
uniprot id: Q6TH11
names: Subcellular Location Annotation
messages: Nucleus

7955:phactr3b
gene id: 7955:phactr3b
uniprot id: A0A8M3AXB9
uniprot id: A0A8M9PUW8
uniprot id: A0A8M9QHN5
uniprot id: Q504B7
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

7955:carm1l
gene id: 7955:carm1l
uniprot id: A0A8M9PTS5
uniprot id: A0A8M9Q698
uniprot id: A0A8M9QGR6
names: Subcellular Location Annotation
messages: Nucleus

7955:stmn1b
gene id: 7955:stmn1b
uniprot id: Q568Q7
names: Similarity
messages: Belongs to the stathmin family.

7955:plcb2
gene id: 7955:plcb2
uniprot id: A0A8M9P9T2
names: Cofactor
names: Function
messages: Binds 1 Ca(2+) ion per subunit.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

7955:npffr1l1
gene id: 7955:npffr1l1
uniprot id: D2Y177
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

7955:si:dkey-23a13.8
gene id: 7955:si:dkey-23a13.8
uniprot id: A0A8N7UVW5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:fgf4
gene id: 7955:fgf4
uniprot id: Q9DFC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Secreted

7955:ank3a
gene id: 7955:ank3a
uniprot id: A0A8M3AIV4
uniprot id: A0A8M3AIX2
uniprot id: A0A8M3AJR3
uniprot id: A0A8M3AJR9
uniprot id: A0A8M3AJS3
uniprot id: A0A8M3AJS7
uniprot id: A0A8M3AR97
uniprot id: A0A8M3ARA5
uniprot id: A0A8M3ARA9
uniprot id: A0A8M3ARB3
uniprot id: A0A8M3ARB6
uniprot id: A0A8M3AU68
uniprot id: A0A8M3AU73
uniprot id: A0A8M3AU79
uniprot id: A0A8M3B2A9
uniprot id: A0A8M3B2B6
uniprot id: A0A8M3B2C4
uniprot id: A0A8M9P0J3
uniprot id: A0A8M9PCL5
uniprot id: A0A8M9PET0
uniprot id: A0A8M9PPF5
uniprot id: A0A8M9PVB2
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

7955:ripply1
gene id: 7955:ripply1
uniprot id: B3DGI6
uniprot id: Q2WG80
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ripply family.
messages: Expressed in the embryonic anterior presomitic mesoderm and in newly formed somites.
messages: Interacts with gro2 via the WRPW motif.
messages: Named after the expression pattern, which decreases in a posterior to anterior direction in somites like a ripple.
messages: Nucleus
messages: Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites.
messages: The WRPW motif is required for binding to tle/groucho proteins.
messages: The ripply homology domain is required for transcriptional repression.

7955:dock7
gene id: 7955:dock7
uniprot id: A0A8M1RR02
uniprot id: A0A8M2BD62
uniprot id: A0A8M2BD70
uniprot id: A0A8M2BD96
uniprot id: A0A8M9PMX0
uniprot id: A0A8M9PMX5
uniprot id: A0A8M9PMZ3
uniprot id: A0A8M9Q0M5
uniprot id: A0A8M9Q0P3
uniprot id: A0A8M9Q6X7
uniprot id: A0A8M9Q6Y2
uniprot id: A0A8M9Q6Y7
uniprot id: A0A8M9Q6Z5
uniprot id: A0A8M9QB36
uniprot id: A0A8M9QB41
uniprot id: A0A8M9QB50
uniprot id: A0A8M9QG48
uniprot id: A0A8M9QG53
uniprot id: A0A8M9QG61
uniprot id: A0A8M9QG66
uniprot id: F1Q8Z1
names: Similarity
messages: Belongs to the DOCK family.

7955:capn2b
gene id: 7955:capn2b
uniprot id: Q504F5
names: Similarity
messages: Belongs to the peptidase C2 family.

7955:cacng3a
gene id: 7955:cacng3a
uniprot id: A0A8M9Q7Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane

7955:gamt
gene id: 7955:gamt
uniprot id: A8E5I0
uniprot id: Q71N41
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.
messages: Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor.
messages: Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor. Important in nervous system development.
messages: Monomer.

7955:aldh3b2
gene id: 7955:aldh3b2
uniprot id: A0A8M3ASB8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

7955:rictora
gene id: 7955:rictora
uniprot id: A0A8M3AS50
uniprot id: A0A8M9QEG1
names: Similarity
messages: Belongs to the RICTOR family.

7955:wnt8b
gene id: 7955:wnt8b
uniprot id: P51029
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Wnt family.
messages: Hindbrain r1, 2 and 5.
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May play a role in the establishment of polarity in the nervous system.
messages: Palmitoleoylation is required for efficient binding to frizzled receptors (By similarity). Depalmitoleoylation leads to Wnt signaling pathway inhibition (By similarity).
messages: Proteolytic processing by tiki1 and tiki2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of wnt8b.
messages: extracellular matrix

7955:wif1
gene id: 7955:wif1
uniprot id: Q9W6F9
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
messages: Highly expressed in unsegmented paraxial mesoderm.
messages: Secreted

7955:LOC101886565
gene id: 7955:LOC101886565
uniprot id: A0A8M6YTT8
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

7955:slx1b
gene id: 7955:slx1b
uniprot id: A0A0R4IAZ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX1 family.
messages: Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
messages: Forms a heterodimer with SLX4.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7955:irf4l
gene id: 7955:irf4l
uniprot id: A0A8M9PCE5
names: Subcellular Location Annotation
messages: Nucleus

7955:LOC110440104
gene id: 7955:LOC110440104
uniprot id: E7EXN4
names: Subcellular Location Annotation
messages: Golgi apparatus membrane

7955:trim35-13
gene id: 7955:trim35-13
uniprot id: A0A8N7TBF6
names: Subcellular Location Annotation
messages: Cytoplasm

7955:kcnj1a.2
gene id: 7955:kcnj1a.2
uniprot id: Q1L8I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

7955:got1l1
gene id: 7955:got1l1
uniprot id: B0UYT6
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

7955:prickle1b
gene id: 7955:prickle1b
uniprot id: F2Z4V3
uniprot id: Q5SP54
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

7955:cycsb
gene id: 7955:cycsb
uniprot id: Q6IQM2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).
messages: Mitochondrion intermembrane space

7955:pi4kb
gene id: 7955:pi4kb
uniprot id: A0A8M2B4L5
uniprot id: F1RBR8
uniprot id: Q49GP3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
messages: Endomembrane system
messages: Expressed as early as 26 hours post-fertilization.
messages: Expressed in the inner ear otic vesicles.
messages: Intron retention.
messages: Knockdown of the gene causes inner ear abnormalities and audiosensory impairment. The semicircular canals of the morphant inner ear are unable to form the characteristic cruciform pattern, resulting in a lack of canal outgrowths and failure of the pillar to properly fuse. In addition the otic vesicles are smaller in the morphants than in wild-type larvae. The morphants also show reduced hearing ability, lacking the brisk startle response observed in wild-type animals at 4 days post-fertilization.
messages: Mitochondrion outer membrane
messages: Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May play an important role the in inner ear development (PubMed:33358777).
messages: Rough endoplasmic reticulum membrane

7955:sf3b6
gene id: 7955:sf3b6
uniprot id: Q6IQM0
names: Subcellular Location Annotation
messages: Nucleus

7955:apc
gene id: 7955:apc
uniprot id: A0A0R4IWH7
uniprot id: A0A8M2B1L0
names: Similarity
messages: Belongs to the adenomatous polyposis coli (APC) family.

7955:syne2b
gene id: 7955:syne2b
uniprot id: A0A8M9QAE9
uniprot id: A0A8M9QG37
names: Similarity
messages: Belongs to the nesprin family.

7955:eral1
gene id: 7955:eral1
uniprot id: B0S6U7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Mitochondrion inner membrane
messages: Mitochondrion matrix
messages: Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly (By similarity).

7955:mtrf1
gene id: 7955:mtrf1
uniprot id: Q5EB09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

7955:ube2t
gene id: 7955:ube2t
uniprot id: Q08BH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in DNA repair.
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Nucleus

7955:slc7a14a
gene id: 7955:slc7a14a
uniprot id: B0UYF2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily.
messages: Lysosome membrane
messages: May be involved in arginine transport.
messages: Morpholino knockdown of the protein causes smaller eyes compared to wild-type animals and aberrant light-induced locomotor response.

7955:LOC100005187
gene id: 7955:LOC100005187
uniprot id: A0A8M6Z397
uniprot id: A0A8M9P406
uniprot id: A0A8M9PDJ2
uniprot id: E7FC94
names: Similarity
messages: Belongs to the PICALM/SNAP91 family.

7955:si:ch211-214c7.5
gene id: 7955:si:ch211-214c7.5
uniprot id: A3KNM4
names: Similarity
messages: Belongs to the UPF0575 family.

7955:irx4a
gene id: 7955:irx4a
uniprot id: A0A8M9PJE4
uniprot id: Q6NZU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

7955:ppa2
gene id: 7955:ppa2
uniprot id: A0A0R4IRJ2
uniprot id: A0A8M9PPE6
uniprot id: Q6P040
names: Similarity
messages: Belongs to the PPase family.

7955:chmp5a
gene id: 7955:chmp5a
uniprot id: E7F143
names: Similarity
messages: Belongs to the SNF7 family.

7955:stambpa
gene id: 7955:stambpa
uniprot id: Q6TH47
names: Cofactor
names: Domain
names: Function
names: Similarity
messages: Belongs to the peptidase M67C family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: The JAMM motif is essential for the protease activity.
messages: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes (By similarity).

7955:atp6v1ab
gene id: 7955:atp6v1ab
uniprot id: E7FCD8
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

7955:tshz3b
gene id: 7955:tshz3b
uniprot id: A0A0R4IDX7
uniprot id: E1AZ73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.
messages: Nucleus

7955:slc2a11b
gene id: 7955:slc2a11b
uniprot id: A0A8M2BCB4
uniprot id: A9ULS7
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

7955:l3mbtl1
gene id: 7955:l3mbtl1
uniprot id: A0A8M1RED0
uniprot id: A0A8M3AND3
names: Subcellular Location Annotation
messages: Nucleus

7955:stx5al
gene id: 7955:stx5al
uniprot id: A0A8M1PD64
names: Similarity
messages: Belongs to the syntaxin family.

7955:si:dkey-35i13.1
gene id: 7955:si:dkey-35i13.1
uniprot id: A0A8M1PU80
names: Subcellular Location Annotation
messages: Membrane

7955:lck
gene id: 7955:lck
uniprot id: Q1RLY5
uniprot id: Q6TPQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Membrane
messages: cytosol

7955:cd79b
gene id: 7955:cd79b
uniprot id: A0A0R4ID76
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:spdl1
gene id: 7955:spdl1
uniprot id: A0A8M9QGH1
uniprot id: A7MD70
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Spindly family.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex.
messages: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. May act as an adapter protein linking the dynein motor complex to various cargos (By similarity).
messages: kinetochore

7955:golph3l
gene id: 7955:golph3l
uniprot id: Q32PS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

7955:LOC110438154
gene id: 7955:LOC110438154
uniprot id: A0A8M9P2H3
names: Similarity
messages: Belongs to the ANKRD34 family.

7955:nkx3.3
gene id: 7955:nkx3.3
uniprot id: F1R3M6
names: Subcellular Location Annotation
messages: Nucleus

7955:mov10b.2
gene id: 7955:mov10b.2
uniprot id: Q1LXK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
messages: P-body
messages: Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (By similarity).

7955:LOC110438944
gene id: 7955:LOC110438944
uniprot id: A0A8M9QJA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

7955:sypl2b
gene id: 7955:sypl2b
uniprot id: A0A8M6Z851
uniprot id: Q6TLG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

7955:p3h2
gene id: 7955:p3h2
uniprot id: A0A0R4IJJ1
names: Similarity
messages: Belongs to the leprecan family.

7955:hmcn1
gene id: 7955:hmcn1
uniprot id: A0A8M2B7L6
uniprot id: A0A8M3AKX8
uniprot id: D7PS96
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:setd6
gene id: 7955:setd6
uniprot id: Q803K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
messages: Nucleus
messages: Protein-lysine N-methyltransferase.

7955:lamb4
gene id: 7955:lamb4
uniprot id: Q8JHV6
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
messages: Domains VI and IV are globular.
messages: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.
messages: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
messages: basement membrane

7955:btg1
gene id: 7955:btg1
uniprot id: Q6PH73
names: Similarity
messages: Belongs to the BTG family.

7955:raraa
gene id: 7955:raraa
uniprot id: Q90271
uniprot id: T2DKU4
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: By retinoic acid in embryos.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Heterodimer; with an rxr molecule. Binds DNA preferentially as a rar/rxr heterodimer.
messages: In the embryo, zygotic expression largely overlaps that of rarab, with high levels in hindbrain, lateral mesoderm and tail bud. In the adult, strong expression in brain and muscle, weaker expression in ovary, liver and digestive tract.
messages: Not expressed maternally. First detected at 8 hours post-fertilization (hpf) during gastrulation, with expression being restricted to the posterior epiblast. Expression then increases, reaching a peak at 24 hpf and decreasing from 30-48 hpf. At 9 hpf, expressed throughout the dorsal epiblast except at the dorsal midline, and ventrally in prospective tail and head regions. At 10-11 hpf, expressed in presumptive hindbrain, posterior neural plate, lateral mesoderm and tail bud. At 12 hpf, strongly expressed in the neural epithelium and tail bud and expressed at low levels elsewhere including the eye. At 24 hpf, restricted to the hindbrain with an anterior border at rhombomere 6-7, to anterior spinal cord and to head mesenchyme just posterior to the otic vesicle. At 48 hpf, hindbrain expression remains and there is diffuse expression in non-neural tissue in the pharyngeal region.
messages: Nucleus
messages: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain patterning.
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

7955:dbpb
gene id: 7955:dbpb
uniprot id: E2E3F4
uniprot id: F1Q4X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

7955:osbpl1a
gene id: 7955:osbpl1a
uniprot id: A0A8M9PQ26
uniprot id: A0A8M9Q392
names: Similarity
messages: Belongs to the OSBP family.

7955:mtfr2
gene id: 7955:mtfr2
uniprot id: A0A8M6YVX2
uniprot id: Q08BD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: May play a role in mitochondrial aerobic respiration. Can also promote mitochondrial fission (By similarity).
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

7955:kcnab1a
gene id: 7955:kcnab1a
uniprot id: A0A8M9P126
uniprot id: A0A8M9PA23
uniprot id: A0A8M9PFF1
uniprot id: A0A8M9PM35
uniprot id: A0A8M9PQ73
uniprot id: Q58EC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

7955:esr1
gene id: 7955:esr1
uniprot id: A0A8M3B0Y2
uniprot id: P57717
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer. Can form a heterodimer with ER-beta (By similarity).
messages: Binds DNA as a homodimer. Can form a heterodimer with ER-beta.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Nucleus
messages: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

7955:lmbrd2b
gene id: 7955:lmbrd2b
uniprot id: Q6P4P2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIMR family.
messages: Cell membrane
messages: May associate with G-protein coupled receptors and regulate downstream signaling pathways.

7955:sema4e
gene id: 7955:sema4e
uniprot id: A4JYS3
uniprot id: F1QNC4
uniprot id: Q1MT68
uniprot id: Q9YHX4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:LOC100331492
gene id: 7955:LOC100331492
uniprot id: A0A8M3ALC4
names: Subcellular Location Annotation
messages: Secreted

7955:tctex1d4
gene id: 7955:tctex1d4
uniprot id: A0A8M2BIP2
uniprot id: A0A8M6Z2J8
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

7955:myo9aa
gene id: 7955:myo9aa
uniprot id: A0A8M3AUN4
uniprot id: A0A8M3BBC1
uniprot id: A0A8M9PQ66
uniprot id: A0A8M9PQ71
uniprot id: A0A8M9Q2U6
uniprot id: A0A8M9Q2V1
uniprot id: A0A8M9Q8Z2
uniprot id: A0A8M9Q8Z6
uniprot id: A0A8M9QD32
uniprot id: A0A8M9QD37
uniprot id: A0A8M9QI24
uniprot id: A0A8M9QI33
uniprot id: E7EZG2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Cytoplasm
messages: Membrane
messages: Morpholino-induced knockdown affects tail morphology, and causes cardiac edema and abnormal swimming in response to tactile stimulation. Morphants show aberrant axons, either short or over-extended, with some axons appearing to branch to the adjacent myotome.
messages: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons (By similarity). Required for the regulation of neurite branching and motor neuron axon guidance (PubMed:27259756).
messages: Synapse
messages: growth cone

7955:trpc5a
gene id: 7955:trpc5a
uniprot id: A0A8M3AXK0
uniprot id: Q1MT28
names: Subcellular Location Annotation
messages: Membrane

7955:map7d1a
gene id: 7955:map7d1a
uniprot id: A0A0R4IEP5
uniprot id: A0A0R4IPE8
uniprot id: A0A8M3AJC2
uniprot id: A0A8M3ATP0
uniprot id: A0A8M9NZC0
uniprot id: A0A8M9P7Z0
uniprot id: A0A8M9PD59
uniprot id: A0A8M9PJJ8
uniprot id: A0A8M9PMI8
names: Similarity
messages: Belongs to the MAP7 family.

7955:tut1
gene id: 7955:tut1
uniprot id: Q4KMD7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cleavage and polyadenylation specificity factor (CPSF) complex.
messages: Belongs to the DNA polymerase type-B-like family.
messages: Binds 1 divalent cation per subunit.
messages: Nucleus speckle
messages: Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase.
messages: The RRM domain is required for terminal uridylyltransferase activity. Together with the zinc-finger domain, binds the 5'-area of U6 snRNA.
messages: The zinc-finger domain is required for terminal uridylyltransferase activity. Together with the RRM domain, binds the 5'-area of U6 snRNA.
messages: nucleolus

7955:tmeff2b
gene id: 7955:tmeff2b
uniprot id: A0A8M2BD12
uniprot id: A0A8M9PMG0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:wasla
gene id: 7955:wasla
uniprot id: A0A8M9PGN8
uniprot id: A2RUY4
names: Subcellular Location Annotation
messages: Nucleus

7955:ucp1
gene id: 7955:ucp1
uniprot id: Q7ZVP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7955:ubr3
gene id: 7955:ubr3
uniprot id: A0A8M9Q4T2
uniprot id: A0A8M9QB29
uniprot id: A0A8M9QJY5
uniprot id: F1QJX5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Recognizes and binds to proteins bearing specific N-terminal residues, leading to their ubiquitination and subsequent degradation (By similarity). Positively regulates hedgehog/shh-signaling pathways that function in eye development, neuronal specification and somite development (PubMed:27195754). Activation of shh up-regulates transcription of ubr3, which in turn promotes hedgehog/shh signaling possibly by controlling negative regulators such as Kif7 (PubMed:27195754).
messages: Expressed in the embryonic retina, central nervous system and trunk (at the protein level).
messages: Heterozygotes fail to form cohesive and stratified epithelium in their optic vesicles. Average somite angle is increased by 30% and the posterior central nervous system displays a gain of Rohon-Beard sensory neurons. Defects are the result of decreased Hh/shh-signaling demonstrated by the reduced expression of the Hh/shh target gene ptch2.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

7955:eif2b5
gene id: 7955:eif2b5
uniprot id: A8WG65
names: Similarity
messages: Belongs to the eIF-2B gamma/epsilon subunits family.

7955:rap2ab
gene id: 7955:rap2ab
uniprot id: B8JIV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Recycling endosome membrane

7955:mettl6
gene id: 7955:mettl6
uniprot id: Q6NY40
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

7955:LOC110437916
gene id: 7955:LOC110437916
uniprot id: A0A8M9PCI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

7955:tagln
gene id: 7955:tagln
uniprot id: A0A8M9QHD6
uniprot id: Q0P4B4
names: Similarity
messages: Belongs to the calponin family.

7955:cd151
gene id: 7955:cd151
uniprot id: A0A8M2BLG9
uniprot id: Q5XJD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7955:mrps30
gene id: 7955:mrps30
uniprot id: A3KP99
names: Subcellular Location Annotation
messages: Mitochondrion

7955:kcnj1a.6
gene id: 7955:kcnj1a.6
uniprot id: Q1L8I9
uniprot id: Q1LUW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

7955:kcnk4a
gene id: 7955:kcnk4a
uniprot id: A0A8M9QL74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

7955:tacc1
gene id: 7955:tacc1
uniprot id: A0A8M9PU00
uniprot id: A0A8M9Q6F6
uniprot id: F1QV49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: Cytoplasm

7955:sept2
gene id: 7955:sept2
uniprot id: A0A8M3B088
uniprot id: F1QQN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Midbody
messages: cilium membrane
messages: spindle

7955:nelfcd
gene id: 7955:nelfcd
uniprot id: Q7ZVZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NELF-D family.
messages: Nucleus

7955:hlfa
gene id: 7955:hlfa
uniprot id: Q08BP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

7955:LOC110437898
gene id: 7955:LOC110437898
uniprot id: A0A8M9P748
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:trappc2l
gene id: 7955:trappc2l
uniprot id: A0A2R8S035
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

7955:msh6
gene id: 7955:msh6
uniprot id: Q803S7
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).

7955:rasl12
gene id: 7955:rasl12
uniprot id: Q7SZ59
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

7955:ugt5c2
gene id: 7955:ugt5c2
uniprot id: A0A8M9P163
uniprot id: A0A8M9PFK2
uniprot id: A0A8M9PMA0
uniprot id: A0A8M9PQD9
uniprot id: Q0P492
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7955:LOC571757
gene id: 7955:LOC571757
uniprot id: A0A8M2B5C5
uniprot id: A0A8M6Z235
uniprot id: A0A8M9PND1
names: Similarity
messages: Belongs to the CUT homeobox family.

7955:foxg1b
gene id: 7955:foxg1b
uniprot id: F6NTK8
uniprot id: Q6NW50
names: Subcellular Location Annotation
messages: Nucleus

7955:dao.1
gene id: 7955:dao.1
uniprot id: A2BGT3
uniprot id: Q4V981
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

7955:si:ch211-51h9.6
gene id: 7955:si:ch211-51h9.6
uniprot id: B0S5C7
names: Similarity
messages: Belongs to the UPF0545 family.

7955:nol6
gene id: 7955:nol6
uniprot id: F1Q4S6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAP family.
messages: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: nucleolus

7955:tmem41aa
gene id: 7955:tmem41aa
uniprot id: Q502G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

7955:pik3c3
gene id: 7955:pik3c3
uniprot id: A0A8M9QGZ6
uniprot id: F1Q9F3
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

7955:cyp2u1
gene id: 7955:cyp2u1
uniprot id: A0A8M9PU59
uniprot id: B8A5Q1
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:prl
gene id: 7955:prl
uniprot id: Q569P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

7955:suds3
gene id: 7955:suds3
uniprot id: B8JJJ1
uniprot id: Q6DBU7
names: Subcellular Location Annotation
messages: Nucleus

7955:lcn15
gene id: 7955:lcn15
uniprot id: A0A8M2BJD4
uniprot id: Q0P3U6
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

7955:gstk4
gene id: 7955:gstk4
uniprot id: A0A8M2B5A3
uniprot id: E9QB37
uniprot id: Q1RLT4
names: Similarity
messages: Belongs to the GST superfamily. Kappa family.

7955:LOC110437736
gene id: 7955:LOC110437736
uniprot id: A0A2R8QJG6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:dkk1a
gene id: 7955:dkk1a
uniprot id: A0A8M1P605
uniprot id: A8WGT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

7955:smyhc2
gene id: 7955:smyhc2
uniprot id: B6IDE1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:psmd3
gene id: 7955:psmd3
uniprot id: Q6NYV1
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

7955:serpine1
gene id: 7955:serpine1
uniprot id: A8WGQ0
names: Similarity
messages: Belongs to the serpin family.

7955:trpm4b.2
gene id: 7955:trpm4b.2
uniprot id: F1RC25
names: Subcellular Location Annotation
messages: Membrane

7955:casp7
gene id: 7955:casp7
uniprot id: A0A8M2B368
uniprot id: A0A8M9QIR3
uniprot id: Q503H4
names: Similarity
messages: Belongs to the peptidase C14A family.

7955:crybg3
gene id: 7955:crybg3
uniprot id: A0A8M9Q687
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:LOC103910274
gene id: 7955:LOC103910274
uniprot id: A0A8M6YZ89
uniprot id: A0A8M9Q501
names: Subcellular Location Annotation
messages: Nucleus

7955:supt3h
gene id: 7955:supt3h
uniprot id: A0A0R4IR35
uniprot id: Q6DHL1
names: Subcellular Location Annotation
messages: Nucleus

7955:ntn1a
gene id: 7955:ntn1a
uniprot id: A0A8M9QA53
uniprot id: O42140
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:apoba
gene id: 7955:apoba
uniprot id: A0A8N7T7N7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:tapt1b
gene id: 7955:tapt1b
uniprot id: A2BIE7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Expressed in the otic vesicle at 1 days post fertilization (dpf) (PubMed:26365339). Expressed in mesenchyme pectoral fins surrounding the cartilage of the endoskeletal disc, and in the epithelial cells of the oral cavity at 3 dpf (PubMed:26365339). Expressed weakly in the pronephric duct and the liver at 3 dpf (PubMed:26365339).
messages: Membrane
messages: Plays a role in primary cilia formation (PubMed:26365339). Involved in cartilage and bone development (PubMed:26365339). May play a role in the differentiation of cranial neural crest cells (PubMed:26365339). May act as a downstream effector of hoxc8 during development (By similarity).
messages: centrosome
messages: cilium basal body

7955:prkar1ab
gene id: 7955:prkar1ab
uniprot id: Q567D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

7955:plac8.2
gene id: 7955:plac8.2
uniprot id: A2VD52
names: Similarity
messages: Belongs to the cornifelin family.

7955:bckdk
gene id: 7955:bckdk
uniprot id: B0R159
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

7955:LOC100329806
gene id: 7955:LOC100329806
uniprot id: A0A8M9PDH4
names: Subcellular Location Annotation
messages: Membrane

7955:b3glcta
gene id: 7955:b3glcta
uniprot id: A0A068F9P7
names: Subcellular Location Annotation
messages: Membrane

7955:slc9a2
gene id: 7955:slc9a2
uniprot id: A0A8M6Z819
uniprot id: A9XPA0
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

7955:smndc1
gene id: 7955:smndc1
uniprot id: Q7ZV80
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with spliceosomes.
messages: Belongs to the SMN family.
messages: Cajal body
messages: Involved in spliceosome assembly (By similarity).
messages: Nucleus speckle
messages: The Tudor domain mediates association with dimethylarginines, which are common in snRNP proteins.

7955:LOC100005446
gene id: 7955:LOC100005446
uniprot id: A0A8M1Q288
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

7955:si:ch1073-296d18.1
gene id: 7955:si:ch1073-296d18.1
uniprot id: A0A8M9PNZ8
names: Similarity
messages: Belongs to the ARTD/PARP family.

7955:ndufaf7
gene id: 7955:ndufaf7
uniprot id: Q08BY0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (PubMed:24838397). Acts by mediating symmetric dimethylation of 'Arg-118' of ndufs2 after it assembles into the complex I, stabilizing the early intermediate complex.
messages: Belongs to the NDUFAF7 family.
messages: Impaired NADH:ubiquinone oxidoreductase complex (complex I) assembly.
messages: Mitochondrion

7955:ndp
gene id: 7955:ndp
uniprot id: A0A8M9QKA4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:ptenb
gene id: 7955:ptenb
uniprot id: Q7ZZ56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4.
messages: Belongs to the PTEN phosphatase protein family.
messages: Cytoplasm
messages: Nucleus
messages: PML body
messages: Postsynaptic density
messages: dendritic spine

7955:tmed10
gene id: 7955:tmed10
uniprot id: A0A2R8QEQ4
uniprot id: Q6NWI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:csnk1a1
gene id: 7955:csnk1a1
uniprot id: A0A2R8Q421
uniprot id: Q8JG73
uniprot id: Q8JGT0
uniprot id: Q8JHD9
uniprot id: Q8JHE0
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:radil
gene id: 7955:radil
uniprot id: A7UA95
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the RADIL family.
messages: Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development.
messages: Interacts with RAP1A; in a GTP-dependent manner.
messages: Knockdown results in multiple defects in neural crest-derived lineages such as cartilage, pigment cells, and enteric neurons.
messages: Present at very low level in one-cell embryos, suggesting the presence of maternally deposited transcripts. Increases upon the onset of zygotic transcription (around the 1000-cell stage), eventually peaking at 72 hpf.
messages: Ubiquitously expressed and enriched in the anterior part of the embryos.

7955:dnah5
gene id: 7955:dnah5
uniprot id: A0A8M9PDG5
uniprot id: A0A8M9PJW7
uniprot id: A0A8M9PMV7
names: Similarity
messages: Belongs to the dynein heavy chain family.

7955:zcchc11
gene id: 7955:zcchc11
uniprot id: A0A8M1PS24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B-like family.
messages: Cytoplasm

7955:si:ch73-40a17.3
gene id: 7955:si:ch73-40a17.3
uniprot id: A0A8M6YT79
uniprot id: E7FDT4
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:si:dkey-224e22.2
gene id: 7955:si:dkey-224e22.2
uniprot id: A0A8M3AJT8
uniprot id: A0A8M3AS61
uniprot id: A2BIK1
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

7955:chmp5b
gene id: 7955:chmp5b
uniprot id: Q7T339
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Endosome membrane
messages: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity).
messages: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III).
messages: cytosol

7955:epg5
gene id: 7955:epg5
uniprot id: A5WUT8
names: Function
names: Similarity
messages: Belongs to the EPG5 family.
messages: Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo (By similarity).

7955:arl6ip4
gene id: 7955:arl6ip4
uniprot id: Q502P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL6IP4 family.
messages: May be involved in modulating alternative pre-mRNA splicing.
messages: Nucleus speckle
messages: nucleolus

7955:osbpl10b
gene id: 7955:osbpl10b
uniprot id: A0A8M1RMC5
uniprot id: A0A8M9NZT9
uniprot id: E7FE64
uniprot id: E9QDU3
names: Similarity
messages: Belongs to the OSBP family.

7955:mbtd1
gene id: 7955:mbtd1
uniprot id: A0A8M9QN18
names: Subcellular Location Annotation
messages: Nucleus

7955:ccnjl
gene id: 7955:ccnjl
uniprot id: E7FH57
names: Similarity
messages: Belongs to the cyclin family.

7955:marcksl1a
gene id: 7955:marcksl1a
uniprot id: Q6PD99
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the MARCKS family.
messages: Cell membrane
messages: Detected from 24 to 72 hours post-fertilization (hpf).
messages: Expressed at low levels in brain, eye and muscle.
messages: Involved in the control of cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation.
messages: Morpholino knockdown of the protein results in reduced head and eye size and a ventrally curved body. No significant effect on formation of craniofacial cartilage. Formation of ceratohyal cartilage is disrupted with an abnormal angle relative to wild-type. Morphogenesis of the developing neural tube is abnormal, with a smaller angle between the walls of the hindbrain neuroepithelium at 24 hours post-fertilization (hpf). Retinal development is significantly delayed; no retinal ganglion cells (RGCs) are detected at 30 hours hpf and reduced numbers are found at 60 hpf. Cilium length in Kupffer's vesicle is significantly reduced. Double morpholino knockdown of marcksl1a and marckls1b results in a more pronounced developmental delay in the retina.
messages: cytoskeleton

7955:foxq2
gene id: 7955:foxq2
uniprot id: A7MBZ9
names: Subcellular Location Annotation
messages: Nucleus

7955:sobpb
gene id: 7955:sobpb
uniprot id: A7XYJ6
names: Function
names: Similarity
messages: Belongs to the SOBP family.
messages: Implicated in development of the cochlea.

7955:nprl2
gene id: 7955:nprl2
uniprot id: Q0P403
names: Similarity
messages: Belongs to the NPR2 family.

7955:si:ch73-160i9.2
gene id: 7955:si:ch73-160i9.2
uniprot id: F1QDG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

7955:ngfa
gene id: 7955:ngfa
uniprot id: A0A8M3AY43
uniprot id: B3DG61
uniprot id: O73797
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGF-beta family.
messages: Recombinant ZNT-7 was able to bind to the human p75 neurotrophin receptor/NGFR and to induce tyrosine phosphorylation of the rat NTRK1/TRKA receptor tyrosine kinase, albeit less efficiently than rat NGF. ZNT-7 did not interact with rat NTRK2/TRKB or NTRK3/TRKC, indicating a similar receptor specificity as NGF.
messages: Secreted

7955:taar19o
gene id: 7955:taar19o
uniprot id: A0A8M3B3L9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:si:dkey-51a16.7
gene id: 7955:si:dkey-51a16.7
uniprot id: E9QI65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

7955:grm3
gene id: 7955:grm3
uniprot id: A3KPM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
messages: Interacts with TAMALIN.
messages: Membrane

7955:kcnc1a
gene id: 7955:kcnc1a
uniprot id: A0A8M2BG67
uniprot id: A0A8M9PP12
uniprot id: B3DJD2
uniprot id: E0R7P5
uniprot id: E0R7P6
names: Subcellular Location Annotation
messages: Membrane

7955:si:ch211-167j6.5
gene id: 7955:si:ch211-167j6.5
uniprot id: A0A8M3AVT9
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:gpx1b
gene id: 7955:gpx1b
uniprot id: A0A8M1N295
names: Similarity
messages: Belongs to the glutathione peroxidase family.

7955:wdr75
gene id: 7955:wdr75
uniprot id: Q7ZVR1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the proposed t-UTP subcomplex of the ribosomal small subunit (SSU) processome. SSU processome is composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Ribosome biogenesis factor. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.
messages: nucleolus

7955:dyrk2
gene id: 7955:dyrk2
uniprot id: A0A0R4ITS5
uniprot id: A0A2R8QCS7
uniprot id: Q5RHV3
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

7955:prf1.9
gene id: 7955:prf1.9
uniprot id: E7F996
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

7955:im:6904045
gene id: 7955:im:6904045
uniprot id: A0A2R8QAE8
uniprot id: A0A8M3AR86
names: Similarity
messages: Belongs to the NATD1 family.

7955:magixa
gene id: 7955:magixa
uniprot id: A0A8M9QE50
uniprot id: A0A8M9QIX5
names: Subcellular Location Annotation
messages: Membrane

7955:bmp2b
gene id: 7955:bmp2b
uniprot id: O93369
names: Similarity
messages: Belongs to the TGF-beta family.

7955:kif3cb
gene id: 7955:kif3cb
uniprot id: F1QW58
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:ap2a1
gene id: 7955:ap2a1
uniprot id: A0A8M2BB77
uniprot id: A0A8M2BBC5
uniprot id: A0A8M2BBK5
uniprot id: A0A8M3AQZ7
uniprot id: A0A8M3B121
uniprot id: A0A8M3B8D0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes large subunit family.
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.
messages: coated pit

7955:ip6k2b
gene id: 7955:ip6k2b
uniprot id: Q6DG55
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

7955:LOC100334599
gene id: 7955:LOC100334599
uniprot id: Q7ZT21
names: Similarity
messages: Belongs to the globin family.

7955:slc43a1a
gene id: 7955:slc43a1a
uniprot id: F2Z4V7
names: Subcellular Location Annotation
messages: Membrane

7955:si:ch1073-153i20.4
gene id: 7955:si:ch1073-153i20.4
uniprot id: A0A140LGZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

7955:foxi3b
gene id: 7955:foxi3b
uniprot id: Q7T1C0
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in ionocyte precursors.
messages: Nucleus
messages: Transcription factor required for epithelial cell differentiation (PubMed:17555741, PubMed:17375188). Involved in specification of skin ionocytes from epidermal precursors (PubMed:17555741, PubMed:17375188).

7955:actr2b
gene id: 7955:actr2b
uniprot id: A0A8M9PXU6
uniprot id: Q56A35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).
messages: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.
messages: Belongs to the actin family. ARP2 subfamily.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of actr2/arp2, actr3/arp3, arpc1b, arpc2, arpc3, arpc4 and arpc5.
messages: Component of the Arp2/3 complex.
messages: Nucleus
messages: cytoskeleton

7955:pds5a
gene id: 7955:pds5a
uniprot id: A1L1F4
uniprot id: F1QDE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDS5 family.
messages: Interacts with the cohesin complex. Binds chromatin in a cohesin-dependent manner (By similarity).
messages: May regulate sister chromatid cohesion during mitosis and couple it to DNA replication.
messages: Nucleus

7955:mdm4
gene id: 7955:mdm4
uniprot id: A0A8M2BK21
uniprot id: A0A8M2BKM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.
messages: Nucleus

7955:usp49
gene id: 7955:usp49
uniprot id: Q1MTK1
names: Similarity
messages: Belongs to the peptidase C19 family.

7955:LOC110437723
gene id: 7955:LOC110437723
uniprot id: A0A8M2BBP7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:shoc2
gene id: 7955:shoc2
uniprot id: Q1L8Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SHOC2 family.
messages: Cytoplasm
messages: Nucleus
messages: Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of raf1 kinase and stimulate raf1 activity at specialized signaling complexes (By similarity).

7955:ankrd34c
gene id: 7955:ankrd34c
uniprot id: F1QC31
names: Similarity
messages: Belongs to the ANKRD34 family.

7955:pla2g4aa
gene id: 7955:pla2g4aa
uniprot id: B3DFL0
uniprot id: P50392
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Activated by phosphorylation on a serine residue.
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
messages: Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca(2+).
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity).

7955:slc25a32b
gene id: 7955:slc25a32b
uniprot id: Q5CZP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7955:alg3
gene id: 7955:alg3
uniprot id: A0A8M2BIQ2
uniprot id: Q501Z4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
messages: Belongs to the glycosyltransferase 58 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:cdc42bpaa
gene id: 7955:cdc42bpaa
uniprot id: A0A8M9P0C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: lamellipodium

7955:ankrd45
gene id: 7955:ankrd45
uniprot id: B0S794
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Ankrd45 mutants are viable and show no apparent defects. However mutant larvae developed enlarged livers when induced with liver specific expression of Kras G12V, one of the common mutations of KRAS that leads to cancer in humans.
messages: Cleavage furrow
messages: Cytoplasm
messages: May play a role during cell division.
messages: Midbody ring
messages: Weakly detected in the dorsal forerunner cells at 80% epiboly to bud stages. At the 10-somite stage, strong expression is detected in the otic placodes, Kupffer's vesicles, and floor plate. Later, at 24 hours post-fertilization, is mainly expressed in organs rich in motile cilia, including otic vesicles, pronephric ducts, and floor plates. At later stages, displays a ubiquitous expression pattern.
messages: Widely expressed.

7955:si:ch211-145b13.6
gene id: 7955:si:ch211-145b13.6
uniprot id: A0A8M3APQ8
uniprot id: E7F1B1
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

7955:gpm6bb
gene id: 7955:gpm6bb
uniprot id: Q5CZM4
uniprot id: Q8UUS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

7955:isoc2
gene id: 7955:isoc2
uniprot id: A0JME6
names: Similarity
messages: Belongs to the isochorismatase family.

7955:en1b
gene id: 7955:en1b
uniprot id: A0A8M3B3Y5
uniprot id: Q5BJ08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Engrailed homeobox family.
messages: Nucleus

7955:zgc:101731
gene id: 7955:zgc:101731
uniprot id: A0A8M2B406
uniprot id: Q4V9B6
uniprot id: Q66ID7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: synaptosome

7955:crygm2d10
gene id: 7955:crygm2d10
uniprot id: A8E4S8
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:zgc:153119
gene id: 7955:zgc:153119
uniprot id: A0A8M9PA75
uniprot id: B0V3H4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Actin maturation protease that specifically mediates the cleavage of immature acetylated N-terminal actin, thereby contributing to actin maturation (By similarity). Cleaves N-terminal acetylated methionine of immature cytoplasmic actin after translation (By similarity). Cleaves N-terminal acetylated cysteine of muscle actin after canonical removal of N-terminal methionine (By similarity).
messages: Belongs to the ACTMAP family.
messages: Cytoplasm

7955:acvrl1
gene id: 7955:acvrl1
uniprot id: A0A8M3B616
uniprot id: A0A8M9P4Z5
uniprot id: A0A8M9PKJ3
uniprot id: Q8JFB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

7955:tp53i11b
gene id: 7955:tp53i11b
uniprot id: A0A8M9PA32
uniprot id: Q08BP4
names: Subcellular Location Annotation
messages: Membrane

7955:h3f3a
gene id: 7955:h3f3a
uniprot id: B2GSF5
uniprot id: Q6PI20
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Monoubiquitinated by rag1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin. Phosphorylation on Ser-32 (H3S31ph) is specific to regions bordering centromeres in metaphase chromosomes.
messages: Serine ADP-ribosylation constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Specific interaction of trimethylated form at 'Lys-36' (H3.3K36me3) with zmynd11 is mediated by the encapsulation of Ser-32 residue with a composite pocket formed by the tandem bromo-PWWP domains.
messages: Specifically enriched in modifications associated with active chromatin such as methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with zmynd11; when trimethylated at 'Lys-36' (H3.3K36me3).
messages: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

7955:e2f1
gene id: 7955:e2f1
uniprot id: A0A8M2BLX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

7955:abhd17c
gene id: 7955:abhd17c
uniprot id: Q7ZVZ7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. ABHD17 family.
messages: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards nras.
messages: Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization.
messages: Postsynaptic density membrane
messages: Recycling endosome membrane
messages: dendritic spine

7955:LOC101882206
gene id: 7955:LOC101882206
uniprot id: F1QAG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL family.
messages: Membrane

7955:si:cabz01007802.1
gene id: 7955:si:cabz01007802.1
uniprot id: A0A8M2BE66
names: Similarity
messages: Belongs to the apolipoprotein L family.

7955:tmem237a
gene id: 7955:tmem237a
uniprot id: A0A8M9QFF9
uniprot id: F1Q930
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM237 family.
messages: Component of the transition zone in primary cilia. Required for ciliogenesis.
messages: Fishes lacking both tmem237a and tmem237b display defects in midsomitic embryos, including shortening of the anterior-posterior axis and small anterior structures, kinking of the notochord, and broadening and thinning of the somite.
messages: Membrane
messages: cilium

7955:mlh3
gene id: 7955:mlh3
uniprot id: A0A8M9P5H1
uniprot id: A0A8M9PFG3
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

7955:prpf19
gene id: 7955:prpf19
uniprot id: Q7ZV92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Homotetramer.
messages: Lipid droplet
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
messages: nucleoplasm

7955:ms4a17a.11
gene id: 7955:ms4a17a.11
uniprot id: Q567H8
names: Similarity
messages: Belongs to the MS4A family.

7955:gorab
gene id: 7955:gorab
uniprot id: A0A8M2B7I8
uniprot id: Q7T320
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GORAB family.
messages: Cytoplasm
messages: Golgi apparatus

7955:stil
gene id: 7955:stil
uniprot id: Q8JGS1
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Embryos display defects such as small head, small eyes and dorsally bent body.
messages: Plays an essential role in early embryonic development (PubMed:12006978). Plays an important role in the regulation of centriole duplication (By similarity).
messages: centriole

7955:clspn
gene id: 7955:clspn
uniprot id: A0A8M9P220
names: Subcellular Location Annotation
messages: Nucleus

7955:cxcr2
gene id: 7955:cxcr2
uniprot id: F1Q8T9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:rundc3b
gene id: 7955:rundc3b
uniprot id: B2GSN6
uniprot id: Q5U3W3
names: Similarity
messages: Belongs to the RUNDC3 family.

7955:LOC101882899
gene id: 7955:LOC101882899
uniprot id: A0A8M2BBI0
uniprot id: A0A8M3AR63
names: Function
names: Subcellular Location Annotation
messages: Dynein axonemal particle
messages: In cyliated cells, dynein axonemal particle-specific protein required for deployment of ODA to the axoneme. Interacts with outer dynein arm (ODA) subunits.

7955:cpamd8
gene id: 7955:cpamd8
uniprot id: A0A8M1RP87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

7955:LOC100331149
gene id: 7955:LOC100331149
uniprot id: A0A8M1RLH0
uniprot id: A0A8M3B820
uniprot id: A0A8M9NZ51
names: Similarity
messages: Belongs to the OSBP family.

7955:ulk3
gene id: 7955:ulk3
uniprot id: A4IG43
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:dhps
gene id: 7955:dhps
uniprot id: Q567L8
uniprot id: Q6NYK1
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

7955:foxl2
gene id: 7955:foxl2
uniprot id: Q1JPV2
names: Subcellular Location Annotation
messages: Nucleus

7955:slc35f4
gene id: 7955:slc35f4
uniprot id: A0A8M3AJ82
uniprot id: A0A8M3ARL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

7955:gstk1
gene id: 7955:gstk1
uniprot id: Q6DGU9
names: Similarity
messages: Belongs to the GST superfamily. Kappa family.

7955:dnaaf3
gene id: 7955:dnaaf3
uniprot id: A0A8M9PY38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAAF3 family.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia.

7955:LOC101886149
gene id: 7955:LOC101886149
uniprot id: A0A8M2BFM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parathyroid hormone family.
messages: Secreted

7955:hm13
gene id: 7955:hm13
uniprot id: A0A8M2B8N4
uniprot id: Q6IQA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

7955:ppfia4
gene id: 7955:ppfia4
uniprot id: A0A8M3AXL8
uniprot id: A0A8M3B411
uniprot id: A0A8M3B6V6
uniprot id: A0A8M6Z101
uniprot id: A0A8M9PUM9
uniprot id: A0A8M9Q6Z6
uniprot id: A0A8M9QHG8
uniprot id: A0A8M9QLF9
uniprot id: B0S6H8
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

7955:cep55l
gene id: 7955:cep55l
uniprot id: A0A8M2B241
uniprot id: Q502I3
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cleavage furrow
messages: Cytoplasm
messages: Midbody ring
messages: Morpholino knockdown of the protein increases jaw cartilage disorganization, decreases the size of brain structures and the lateral area and convolution of proximal renal tubules at 4 days post-fertilization (dpf) (PubMed:28264986). Embryos with CRISPR-induced cep55l null mutations display altered craniofacial patterning and atrophy of the proximal renal tubules (PubMed:28264986).
messages: Plays a role in mitotic exit and cytokinesis. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis. Not required for microtubule nucleation (By similarity). Plays a role in the development of the brain and kidney (PubMed:28264986).
messages: centriole
messages: centrosome

7955:tnnt2b
gene id: 7955:tnnt2b
uniprot id: A0A8M6YZU8
uniprot id: A0A8M6Z708
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

7955:fam76b
gene id: 7955:fam76b
uniprot id: A0A8M3B2A7
uniprot id: Q6PBM7
names: Similarity
messages: Belongs to the FAM76 family.

7955:mc5ra
gene id: 7955:mc5ra
uniprot id: A3KGQ1
uniprot id: Q8JGW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.

7955:sgol1
gene id: 7955:sgol1
uniprot id: A0A8M9PNJ5
uniprot id: A1L1S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

7955:LOC103911283
gene id: 7955:LOC103911283
uniprot id: A0A8M9PZN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

7955:vat1
gene id: 7955:vat1
uniprot id: Q4KME8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

7955:elavl2
gene id: 7955:elavl2
uniprot id: A0A2R8S0A2
uniprot id: Q6GQM6
names: Similarity
messages: Belongs to the RRM elav family.

7955:skor1a
gene id: 7955:skor1a
uniprot id: A0A2R8S0A8
uniprot id: A0A8M6YZ33
uniprot id: A0A8M6YZW4
uniprot id: A0A8M6YZW8
uniprot id: A0A8M6Z1F4
uniprot id: A0A8M6Z7M0
uniprot id: A0A8M9QBL3
uniprot id: B3DIV1
names: Similarity
messages: Belongs to the SKI family.

7955:zgc:165555
gene id: 7955:zgc:165555
uniprot id: A3KPR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:wdr82
gene id: 7955:wdr82
uniprot id: Q6NV31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SWD2 family.
messages: Chromosome
messages: Component of the SET1 complex.
messages: Nucleus
messages: Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs).

7955:tmem39b
gene id: 7955:tmem39b
uniprot id: A0A8M3B582
uniprot id: Q7ZW11
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TMEM39 family.
messages: Endoplasmic reticulum membrane
messages: Expressed in the ovary, followed by the intestine and brain.
messages: Homozygous knockout fish for tmem39b are viable and fertile and seem normal. However, adult males have a significantly lower standard length and body weigh.
messages: May protect the cells against DNA damage caused by exposure to the cold-warming stress and facilitates tissue damage repair during the recovery phase.
messages: Membrane

7955:gpr34l
gene id: 7955:gpr34l
uniprot id: Q6XCC5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:serpinh1b
gene id: 7955:serpinh1b
uniprot id: F1QQ04
names: Similarity
messages: Belongs to the serpin family.

7955:atrx
gene id: 7955:atrx
uniprot id: A0A8M9QKH6
uniprot id: E7F4M2
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

7955:si:ch73-56d11.3
gene id: 7955:si:ch73-56d11.3
uniprot id: E9QHI6
names: Similarity
messages: Belongs to the MS4A family.

7955:itk
gene id: 7955:itk
uniprot id: O42200
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

7955:zgc:64201
gene id: 7955:zgc:64201
uniprot id: Q6PFS2
names: Similarity
messages: Belongs to the PRORSD1 family.

7955:pglyrp6
gene id: 7955:pglyrp6
uniprot id: A0A0R4IJX9
uniprot id: B7ZUU1
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

7955:myhz1.1
gene id: 7955:myhz1.1
uniprot id: B8A568
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:opn8b
gene id: 7955:opn8b
uniprot id: A0A8M9PSX7
uniprot id: F1QCL1
names: Subcellular Location Annotation
messages: Membrane

7955:LOC100330864
gene id: 7955:LOC100330864
uniprot id: G3G7U0
uniprot id: G3G7U2
names: Cofactor
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.

7955:tomm7
gene id: 7955:tomm7
uniprot id: Q0P4E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

7955:dram2b
gene id: 7955:dram2b
uniprot id: F1R7U0
uniprot id: Q6IQI0
names: Subcellular Location Annotation
messages: Membrane

7955:adsl
gene id: 7955:adsl
uniprot id: F1R293
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

7955:eogt
gene id: 7955:eogt
uniprot id: A0A8M9QDI0
uniprot id: X1WGG5
names: Similarity
messages: Belongs to the glycosyltransferase 61 family.

7955:itpr1a
gene id: 7955:itpr1a
uniprot id: A0A8M2BDG0
uniprot id: A0A8M3ATJ5
uniprot id: A0A8M3B0M5
uniprot id: A0A8M3B3K9
uniprot id: A0A8M6YZS1
uniprot id: A0A8M6Z7H7
uniprot id: A0A8M9Q732
uniprot id: F8W4B1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Membrane
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

7955:uox
gene id: 7955:uox
uniprot id: Q6DG85
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
messages: Competitively inhibited by xanthine.
messages: Homotetramer; dimer of dimers.
messages: Peroxisome

7955:hlfb
gene id: 7955:hlfb
uniprot id: A0A8M2B317
uniprot id: E2E3F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

7955:taar11
gene id: 7955:taar11
uniprot id: Q5QNN2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:chd1l
gene id: 7955:chd1l
uniprot id: Q7ZU90
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage. Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage. Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair. Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner.
messages: Adopts an inactive conformation in absence of DNA damage. Binding to poly-ADP-ribosylated histones activates the ATP-dependent chromatin remodeler activity.
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Chromosome
messages: Interacts with nucleosomes; interacts with the acidic patch of histones.
messages: Nucleus
messages: The macro domain mediates non-covalent poly(ADP-ribose)-binding and recruitment to DNA damage sites. Mediates auto-inhibition of ATPase activity by interacting with the N-terminal ATPase module, encompassing the helicase ATP-binding domain and helicase C-terminal domain. Binding to poly-ADP-ribosylated histones upon DNA damage releases the auto-inhibition by the macro domain and trigger ATPase activity. Does not bind monomeric ADP-ribose and mono-ADP-ribose fails to release the auto-inhibition of the ATPase module by the macro domain.

7955:tnfsf14
gene id: 7955:tnfsf14
uniprot id: E7FBC0
names: Similarity
messages: Belongs to the tumor necrosis factor family.

7955:mapta
gene id: 7955:mapta
uniprot id: A0A8M9QEI5
names: Subcellular Location Annotation
messages: cytoskeleton

7955:rock2a
gene id: 7955:rock2a
uniprot id: Q90Y37
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by RHOA binding. Inhibited by Y-27632.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cell membrane
messages: Homodimer.
messages: Nucleus
messages: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.
messages: centrosome

7955:si:ch1073-278o19.1
gene id: 7955:si:ch1073-278o19.1
uniprot id: A0A0R4IDX9
uniprot id: A0A8M9Q7T5
names: Activity Regulation
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ninjurin family.
messages: Cell membrane
messages: Composed of 4 alpha helices: 2 hydrophobic transmembrane regions (alpha3 and alpha4) and 2 alpha helices (alpha1 and alpha2). Alpha1 and alpha2 feature one hydrophobic side and a hydrophilic side. In normal conditions, NINJ1 is inactivated and alpha1 and alpha2 helices are not inserted into the membrane. Following NINJ1 activation, alpha1 and alpha2 helices insert into the membrane and drive NINJ1 oligomerization via interactions between alpha3 and alpha4 and the hydrophobic face of alpha1 from an adjacent subunit. Such structures disrupt membrane integrity and form a lesion through the introduction of the hydrophilic faces of alpha1 and alpha2 into the hydrophobic membrane.
messages: Effector of necroptotic and pyroptotic programmed cell death that mediates plasma membrane rupture (cytolysis) (By similarity). Acts downstream of Gasdermin (GSDMA, GSDMB, GSDMC, GSDMD, or GSDME) or MLKL during pyroptosis or necroptosis, respectively: oligomerizes in response to death stimuli and promotes plasma membrane rupture by introducing hydrophilic faces of 2 alpha helices into the hydrophobic membrane, leading to release intracellular molecules named damage-associated molecular patterns (DAMPs) that propagate the inflammatory response (By similarity). Acts as a regulator of Toll-like receptor 4 (TLR4) signaling triggered by lipopolysaccharide (LPS) during systemic inflammation; directly binds LPS (By similarity). Involved in leukocyte migration during inflammation by promoting transendothelial migration of macrophages via homotypic binding (By similarity). Promotes the migration of monocytes across the brain endothelium to central nervous system inflammatory lesions (By similarity). Also acts as a homophilic transmembrane adhesion molecule involved in various processes such as axonal growth, cell chemotaxis and angiogenesis (By similarity). Promotes cell adhesion by mediating homophilic interactions via its extracellular N-terminal adhesion motif (N-NAM) (By similarity). Also involved in striated muscle growth and differentiation (PubMed:31091274).
messages: Homooligomer; in response to death stimuli, homooligomerizes into long, highly branched filaments and large, ring-shaped structures in the membrane.
messages: In normal conditions, NINJ1 is inactivated. In response to death stimuli, homooligomerizes and disrupts membrane integrity by introducing the hydrophilic faces of alpha1 and alpha2 helices into the hydrophobic membrane (By similarity). Homooligomerization and ability to mediate plasma membrane rupture is inhibited by glycine; it is unclear whether glycine directly or indirectly inhibits homooligomerization (By similarity).
messages: Membrane
messages: Morpholino knockdown of the protein results in impaired heart and skeletal muscle development.
messages: Synaptic cell membrane

7955:ccdc79
gene id: 7955:ccdc79
uniprot id: Q1LX29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TERB1 family.
messages: Component of the MAJIN-TERB1-TERB2 complex.
messages: Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the MAJIN-TERB1-TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex.
messages: Nucleus inner membrane
messages: telomere

7955:supt5h
gene id: 7955:supt5h
uniprot id: A0A8M1P6F8
uniprot id: A0A8M9Q0J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT5 family.
messages: Nucleus

7955:paf1
gene id: 7955:paf1
uniprot id: Q4U0S5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PAF1 family.
messages: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). PAF1C seems to be required for multiple steps in cardiac formation. Involved in the migration of myocardial precursors to the midline and the differentiation of the atrioventricular boundary in the developing heart.
messages: Component of the PAF1 complex, which at least consists of cdc73, paf1, leo1, ctr9 and rtf1 (By similarity). The PAF1 complex interacts with PHF5A (By similarity). Interacts with ctr9 (PubMed:21338598).
messages: Nucleus

7955:si:dkey-192d15.2
gene id: 7955:si:dkey-192d15.2
uniprot id: A0A0R4IF32
names: Similarity
messages: Belongs to the apolipoprotein L family.

7955:prf1.2
gene id: 7955:prf1.2
uniprot id: A0A0R8WGG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

7955:spcs3
gene id: 7955:spcs3
uniprot id: Q6NWJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS3 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:gmppaa
gene id: 7955:gmppaa
uniprot id: A0A286Y8P7
uniprot id: Q6GMK8
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

7955:rom1a
gene id: 7955:rom1a
uniprot id: Q6NYK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRPH2/ROM1 family.
messages: Membrane

7955:cox10
gene id: 7955:cox10
uniprot id: F1QL30
uniprot id: Q08C12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Belongs to the ubiA prenyltransferase family.
messages: Converts protoheme IX and farnesyl diphosphate to heme O.
messages: Membrane
messages: Mitochondrion membrane

7955:nras
gene id: 7955:nras
uniprot id: Q6DGD1
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

7955:bcl7bb
gene id: 7955:bcl7bb
uniprot id: A2BIL8
uniprot id: B2GTJ2
names: Similarity
messages: Belongs to the BCL7 family.

7955:mbd4
gene id: 7955:mbd4
uniprot id: A0A097ZPG7
uniprot id: A0A8M6Z2E4
uniprot id: A0A8M6Z8A1
names: Subcellular Location Annotation
messages: Nucleus

7955:pacsin1a
gene id: 7955:pacsin1a
uniprot id: A0A2R9YJM4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cell projection
messages: Cytoplasm
messages: Membrane

7955:cxcl12b
gene id: 7955:cxcl12b
uniprot id: Q6V9B5
names: Similarity
messages: Belongs to the intercrine alpha (chemokine CxC) family.

7955:avd
gene id: 7955:avd
uniprot id: A0A8M1P1N5
names: Similarity
messages: Belongs to the avidin/streptavidin family.

7955:rpl11
gene id: 7955:rpl11
uniprot id: Q6IQI6
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

7955:timmdc1
gene id: 7955:timmdc1
uniprot id: Q568N3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the intermediate 315 kDa subcomplex of incompletely assembled complex I.
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I (By similarity).
messages: Mitochondrion membrane

7955:slc25a47b
gene id: 7955:slc25a47b
uniprot id: A4QNX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane

7955:ndufb9
gene id: 7955:ndufb9
uniprot id: Q567Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

7955:ano3
gene id: 7955:ano3
uniprot id: A0A8M9PVQ2
uniprot id: A0A8M9PZ95
uniprot id: X1WC49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

7955:spsb3a
gene id: 7955:spsb3a
uniprot id: B1H1G8
names: Function
names: Similarity
messages: Belongs to the SPSB family.
messages: May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

7955:klc3
gene id: 7955:klc3
uniprot id: A0A8M3AII1
uniprot id: Q08CF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

7955:usp12a
gene id: 7955:usp12a
uniprot id: A4FUN7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C19 family. USP12/USP46 subfamily.
messages: Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with wdr48 to have a high activity.
messages: Interacts with WDR48.

7955:ms4a17a.12
gene id: 7955:ms4a17a.12
uniprot id: A0A8M1P8N1
names: Similarity
messages: Belongs to the MS4A family.

7955:ssh1a
gene id: 7955:ssh1a
uniprot id: A0A8M2BCF3
uniprot id: A0A8M3ASC3
uniprot id: A0A8M3B2D8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

7955:pdpk1b
gene id: 7955:pdpk1b
uniprot id: Q6NZV1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.

7955:abi1b
gene id: 7955:abi1b
uniprot id: A0A286YAJ7
uniprot id: A0A8M2BIE7
uniprot id: Q08C61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

7955:stag2b
gene id: 7955:stag2b
uniprot id: A0A0R4IZR5
uniprot id: E7FE97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

7955:si:dkey-150i13.2
gene id: 7955:si:dkey-150i13.2
uniprot id: A0A8M1QL66
uniprot id: A0A8M9P5D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7955:atp13a1
gene id: 7955:atp13a1
uniprot id: F1R1X4
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.

7955:pitpnm3
gene id: 7955:pitpnm3
uniprot id: E7F006
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

7955:cdk5r2b
gene id: 7955:cdk5r2b
uniprot id: Q6DEG2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin-dependent kinase 5 activator family.
messages: Cell membrane
messages: Heterodimer of a catalytic subunit and a regulatory subunit.
messages: Membrane

7955:si:ch73-368j24.1
gene id: 7955:si:ch73-368j24.1
uniprot id: A0A8M9Q225
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:si:ch211-209n20.1
gene id: 7955:si:ch211-209n20.1
uniprot id: A0A8M9PN31
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

7955:fam166b
gene id: 7955:fam166b
uniprot id: A0A0R4I9Q0
uniprot id: A0A8M9PTB9
names: Similarity
messages: Belongs to the CIMIP2 family.

7955:atp5b
gene id: 7955:atp5b
uniprot id: A8WGC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

7955:LOC100535364
gene id: 7955:LOC100535364
uniprot id: A0A8M1REU5
names: Subcellular Location Annotation
messages: Membrane

7955:ccno
gene id: 7955:ccno
uniprot id: A0A8M2BGJ4
names: Similarity
messages: Belongs to the cyclin family.

7955:si:dkey-82j4.2
gene id: 7955:si:dkey-82j4.2
uniprot id: A0A8M9PY01
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

7955:cltb
gene id: 7955:cltb
uniprot id: A0A286Y9F1
uniprot id: A0A8M2BFK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

7955:gbp1
gene id: 7955:gbp1
uniprot id: Q6DHP7
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

7955:prdm1a
gene id: 7955:prdm1a
uniprot id: Q68EH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

7955:si:dkey-262k9.4
gene id: 7955:si:dkey-262k9.4
uniprot id: A0A8M9NYR0
uniprot id: E7FEN3
names: Similarity
messages: Belongs to the FXYD family.

7955:ufm1
gene id: 7955:ufm1
uniprot id: A0A0R4I9C6
uniprot id: Q803Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UFM1 family.
messages: Cytoplasm
messages: Interacts with uba5. Interacts with ufc1.
messages: Nucleus
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the ufm1-activating E1 enzyme uba5, the ufm1-conjugating E2 enzyme ufc1, and the ufm1-ligase E3 enzyme ufl1. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

7955:ucmab
gene id: 7955:ucmab
uniprot id: K7NRG1
uniprot id: Q6NWB6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UCMA family.
messages: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.
messages: Proteolytically cleaved by a furin-like convertase to generate a persistent C-terminal fragment found in almost the entire cartilage matrix, and affecting osteoblast differentiation.
messages: Sulfated on tyrosine residues.
messages: extracellular matrix

7955:imp3
gene id: 7955:imp3
uniprot id: A0A2R8QAU3
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

7955:slc39a7
gene id: 7955:slc39a7
uniprot id: Q6DGU8
uniprot id: Q9PUB8
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.
messages: Endoplasmic reticulum membrane
messages: Expressed ubiquitously at early stages of somitogenesis (at around 2 hpf). At 24 hpf, detected in the forebrain-proximal part of retina, and at later stages of development around the retina.
messages: Highly expressed in brain and eye of adult zebrafish.
messages: Homodimer.
messages: Membrane
messages: Morpholino knockdown of slc39a7 protein causes neurodevelopmental impairments, decreased head size, smaller eyes, shorter palates, and shorter and curved spinal cords, as well as a reduction in intracellular Zn(2+) content in the brain. These morpholino elicited phenotypes can be rescued with Zn(2+) supplementation.
messages: Transports Zn(2+) from the endoplasmic reticulum (ER)/Golgi apparatus to the cytosol, playing an essential role in the regulation of cytosolic zinc levels (By similarity). Plays a role in maintaining zinc homeostasis and organism development especially in eyes, brain, and gills (PubMed:22912764).
messages: cis-Golgi network membrane

7955:trmt2b
gene id: 7955:trmt2b
uniprot id: A0A0R4I9B6
uniprot id: A4QP75
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and 12S rRNA. Catalyzes the methylation of uridine at position 54 (m5U54) in all tRNAs. Specifically methylates the uridine in position 429 of 12S rRNA (m5U429). Does not affect RNA stability or mitochondrial translation.
messages: Mitochondrion

7955:mpp3a
gene id: 7955:mpp3a
uniprot id: A0A8M3B8G0
uniprot id: A0A8M9PTM0
uniprot id: X1WFJ8
names: Similarity
messages: Belongs to the MAGUK family.

7955:gpr137c
gene id: 7955:gpr137c
uniprot id: A0A8M2BHJ8
uniprot id: Q5U3S6
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

7955:zgc:114119
gene id: 7955:zgc:114119
uniprot id: Q4V8V8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

7955:tenm3
gene id: 7955:tenm3
uniprot id: Q9W7R4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cell membrane
messages: Expressed at the notochord and the somite around tailbud stage. At 14 hours post-fertilization (hpf), expressed in the somites, notochord, and the brain. Found in the rhombomere 3 (r3) and r5. Expressed in the optic vesicles and a region covering the caudal diencephalon and the mesencephalon with the strongest expression at its most anterior part. Mesodermal expression is observed in both forming and formed somites. In forming and newly formed somites, transcripts are distributed evenly. In contrast, distribution in somites located on more anterior trunk seems to be uneven, strongest in the ventral, intermediate in the dorsal, and weakest in the medial parts. At 23 hpf, there is no expression in the medial parts of somites. Expression in somites fades away by 36 hpf. At 20 hpf, additional expression is detected in the pharyngeal arches.
messages: Expressed by retinal ganglion cells and their presynaptic amacrine and postsynaptic tectal cell targets.
messages: Homodimer; disulfide-linked; to mediate homophilic cell adhesion.
messages: Involved in neural development by regulating the establishment of proper connectivity within the nervous system (PubMed:24183672, PubMed:27374343). Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion (By similarity). Required by retinal ganglion cells for acquisition of their correct morphological and functional connectivity, thereby playing a key role in the development of the visual pathway (PubMed:24183672, PubMed:27374343).
messages: Morpholino knockdown of the protein causes retinal ganglion cell dendrite stratification defects within the inner plexiform layer, as well as mistargeting of dendritic processes into outer portions of the retina.
messages: axon

7955:gde1
gene id: 7955:gde1
uniprot id: Q7ZUV3
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

7955:zgc:136963
gene id: 7955:zgc:136963
uniprot id: Q29R89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

7955:ctc1
gene id: 7955:ctc1
uniprot id: A0JMF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTC1 family.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication (By similarity).
messages: Component of the CST complex.
messages: Nucleus
messages: telomere

7955:hdac3
gene id: 7955:hdac3
uniprot id: Q803C3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 1 subfamily.
messages: Cytoplasm
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Also functions as deacetylase for non-histone targets. In addition to protein deacetylase activity, also acts as protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation and de-2-hydroxyisobutyrylation, respectively.
messages: Nucleus

7955:valopa
gene id: 7955:valopa
uniprot id: Q9IB88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

7955:mapre3a
gene id: 7955:mapre3a
uniprot id: A0A8M2B5B2
uniprot id: Q4V903
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

7955:rpl24
gene id: 7955:rpl24
uniprot id: A0A0R4IMS3
uniprot id: Q8JGR4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (By similarity). Plays an essential role in early embryonic development (PubMed:12006978).
messages: Cytoplasm
messages: Embryos show various defects including smaller head and eyes.

7955:zhx3
gene id: 7955:zhx3
uniprot id: F1QQ52
uniprot id: F1R0G0
uniprot id: Q6W5B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

7955:ankrd13d
gene id: 7955:ankrd13d
uniprot id: A0A0R4IY87
uniprot id: A0A8M3AHV3
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

7955:fam167ab
gene id: 7955:fam167ab
uniprot id: Q5RFZ7
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

7955:fxr2
gene id: 7955:fxr2
uniprot id: Q6NY99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMR1 family.
messages: Cytoplasmic ribonucleoprotein granule

7955:irx7
gene id: 7955:irx7
uniprot id: Q90YX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

7955:pygma
gene id: 7955:pygma
uniprot id: Q503C7
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

7955:fam46ba
gene id: 7955:fam46ba
uniprot id: A0JPF6
names: Similarity
messages: Belongs to the TENT family.

7955:alpk2
gene id: 7955:alpk2
uniprot id: F1QU13
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
messages: Detected at 13 hours post-fertilization (hpf) in the precursor cells of adaxial cells (slow twitch muscle fibers) of the paraxial mesoderm (PubMed:29888752). At 22 hpf, detected in the developing heart (PubMed:29888752).
messages: Expressed in developing cardiac tissue.
messages: Morpholino knockdown in the embryo causes reduced heart beating rates and cardiomyocyte numbers at 48 hours post-fertilization (hpf) (PubMed:29888752). At 72 hpf, embryos display pericardial and yolk sac effusion and pronounced cardiac malformation coupled with defects in posterior development (PubMed:29888752). Embryos also lack ventricular epicardium at 96 hpf (PubMed:29888752).
messages: Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation (By similarity). Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling (PubMed:29888752).

7955:slc25a23b
gene id: 7955:slc25a23b
uniprot id: A0A8M9PHW1
uniprot id: Q5PNM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

7955:ephx1
gene id: 7955:ephx1
uniprot id: Q7ZVB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

7955:gapvd1
gene id: 7955:gapvd1
uniprot id: A0A2R8Q516
uniprot id: A0A8M3AVA8
uniprot id: A0A8M3AVB1
uniprot id: A0A8M3B237
uniprot id: A0A8M3BBW9
uniprot id: E7F237
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAPVD1 family.
messages: Membrane

7955:atp1a1a.3
gene id: 7955:atp1a1a.3
uniprot id: Q9DEY3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC568680
gene id: 7955:LOC568680
uniprot id: A0A8M3AV76
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:bloc1s3
gene id: 7955:bloc1s3
uniprot id: Q4V924
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BLOC1S3 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).
messages: Cytoplasm

7955:zgc:77086
gene id: 7955:zgc:77086
uniprot id: Q6NXB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

7955:txnrd1
gene id: 7955:txnrd1
uniprot id: A0A8M1PCD1
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

7955:mpv17
gene id: 7955:mpv17
uniprot id: Q5TZ51
names: Disease Annotation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Genetic defects resulting in MPV17 loss are responsible for the transparent (tra) mutant phenotype. 'tra' fishes display pigmentation abnormalities and lack of cells derived from the neural crest, such as iridophores and, at later stages of development, melanophores (PubMed:23862018). MPV17-null larvae show disruption of mitochondrial ultrastructure in liver cells with mitochondrial ballooning and disappearance of cristae, and impaired oxidative phosphorylation, insufficient pyrimidine synthesis, and mtDNA depletion (PubMed:30833296).
messages: Involved in mitochondrial homeostasis, and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance (PubMed:30833296). Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress (By similarity).
messages: Mitochondrion inner membrane
messages: Widely expressed.

7955:nes
gene id: 7955:nes
uniprot id: P86839
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the intermediate filament family.
messages: Expression is not detected before the 3-somite stage at 10-11 hours post-fertilization. Earliest expression is detected during mid-neurulation.
messages: Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such as vimentin and alpha-internexin, preferentially forms heterodimers (By similarity).
messages: Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). Required for brain and eye development.
messages: Widely expressed throughout the developing nervous system at 24 hours post-fertilization (hpf). As development progresses, expression becomes restricted to proliferative zones of the developing and postembryonic central nervous system. In the peripheral nervous system, expressed in the cranial ganglia. Also expressed in mesodermal muscle precursor cells and in cranial mesenchymal tissue.

7955:gngt2a
gene id: 7955:gngt2a
uniprot id: Q6PBR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

7955:asna1
gene id: 7955:asna1
uniprot id: Q6IQE5
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: GET3-deficient embryos have impaired swim bladder inflation and reduced body size. From day 5 post-fertilization, the mutants display abnormal cardiac contractions and decreased blood flow velocity in the dorsal aorta and cardinal vein. Mutant hearts also have irregular shape and thin walls.
messages: Homodimer. Component of the Golgi to ER traffic (GET) complex, which is composed of GET1/WRB, CAMLG/GET2 and GET3/TRC40. Within the complex, CAMLG and GET1 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer.

7955:rab9b
gene id: 7955:rab9b
uniprot id: A0A8M3BF01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: phagosome membrane

7955:si:ch211-131e11.19
gene id: 7955:si:ch211-131e11.19
uniprot id: F1RBS9
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:nup107
gene id: 7955:nup107
uniprot id: Q5RGI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup84/Nup107 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC).
messages: nuclear pore complex

7955:scdb
gene id: 7955:scdb
uniprot id: A0A8M2B301
uniprot id: Q501V8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

7955:pde9al
gene id: 7955:pde9al
uniprot id: A0A8N7UT66
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

7955:lctla
gene id: 7955:lctla
uniprot id: A0A8M9QBT7
uniprot id: Q6DGC8
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

7955:ppardb
gene id: 7955:ppardb
uniprot id: A9C4A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

7955:bmp4
gene id: 7955:bmp4
uniprot id: O57574
names: Similarity
messages: Belongs to the TGF-beta family.

7955:atp6v0a1b
gene id: 7955:atp6v0a1b
uniprot id: A0A8M3AYX3
uniprot id: Q502H9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

7955:LOC566927
gene id: 7955:LOC566927
uniprot id: A0A2R8QG20
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:txlng
gene id: 7955:txlng
uniprot id: F1QZ20
names: Similarity
messages: Belongs to the taxilin family.

7955:pard6gb
gene id: 7955:pard6gb
uniprot id: Q6TNS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

7955:or104-1
gene id: 7955:or104-1
uniprot id: Q2PRL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:zp3
gene id: 7955:zp3
uniprot id: Q9PWC7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPC subfamily.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

7955:slc12a9
gene id: 7955:slc12a9
uniprot id: A0A8M9PY34
uniprot id: A2BFP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Membrane
messages: Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function.

7955:fgfr1a
gene id: 7955:fgfr1a
uniprot id: A0A891XJP9
uniprot id: A0A891XJS9
uniprot id: Q90Z00
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer and proceeds in a highly ordered manner. Phosphotyrosine residues provide docking sites for interacting proteins and so are crucial for FGFR1 function and its regulation (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Initially expressed in adaxial mesoderm with transcripts distinctly localized to the anterior portion of each half-somite. Hereupon, also strongly expressed in the otic vesicles, branchial arches and the brain, especially at the midbrain-hindbrain boundary (MHB).
messages: Membrane
messages: Monomer. Homodimer after ligand binding (By similarity). Interacts with cnpy1.
messages: N-glycosylated in the endoplasmic reticulum. The N-glycan chains undergo further maturation to an Endo H-resistant form in the Golgi apparatus (By similarity).
messages: Nucleus
messages: Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by sequential autophosphorylation on tyrosine residues (By similarity).
messages: The second and third Ig-like domains directly interact with fibroblast growth factors (FGF) and heparan sulfate proteoglycans. Isoforms lacking the first Ig-like domain have higher affinity for fibroblast growth factors (FGF) and heparan sulfate proteoglycans than isoforms with all three Ig-like domains (By similarity).
messages: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by ubiquitination, internalization and degradation (By similarity).
messages: Ubiquitinated. FGFR1 is rapidly ubiquitinated after autophosphorylation, leading to internalization and degradation (By similarity).
messages: Vesicle
messages: cytosol

7955:adcy9
gene id: 7955:adcy9
uniprot id: A0A8M1RTI1
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

7955:fitm1
gene id: 7955:fitm1
uniprot id: A0A8M1P5Q1
uniprot id: Q5CZN0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIT family. FIT1 subfamily.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol.
messages: May play an important role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (By similarity). May directly bind to diacylglycerol (DAGs) and triacylglycerol (By similarity).
messages: Membrane

7955:cdc123
gene id: 7955:cdc123
uniprot id: A0A8M3AYH2
uniprot id: Q6PC40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC123 family.
messages: Cytoplasm
messages: Required for S phase entry of the cell cycle.

7955:rps3
gene id: 7955:rps3
uniprot id: Q7ZVD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: spindle

7955:lin9
gene id: 7955:lin9
uniprot id: Q5RHQ8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lin-9 family.
messages: Component of the DREAM complex.
messages: Nucleus

7955:supt20
gene id: 7955:supt20
uniprot id: A0A8M2BJX2
uniprot id: A0A8M2BJZ0
uniprot id: A0A8M2BKJ0
uniprot id: F1QKI6
names: Similarity
messages: Belongs to the SPT20 family.

7955:hsd17b10
gene id: 7955:hsd17b10
uniprot id: Q5XJS8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:LOC101887156
gene id: 7955:LOC101887156
uniprot id: A0A8M9P3V2
names: Similarity
messages: Belongs to the SLT11 family.

7955:sult5a1
gene id: 7955:sult5a1
uniprot id: F1QV04
uniprot id: Q08C30
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

7955:mcm3
gene id: 7955:mcm3
uniprot id: Q5RIC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

7955:naf1
gene id: 7955:naf1
uniprot id: F1QXL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAF1 family.
messages: Nucleus

7955:nipal4
gene id: 7955:nipal4
uniprot id: F1QHP8
uniprot id: Q6DG01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

7955:LOC101885590
gene id: 7955:LOC101885590
uniprot id: A0A0G2KKG9
names: Similarity
messages: Belongs to the TGF-beta family.

7955:LOC100537437
gene id: 7955:LOC100537437
uniprot id: A0A8M9P9J9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:plk2b
gene id: 7955:plk2b
uniprot id: A6H8T5
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

7955:pimr46
gene id: 7955:pimr46
uniprot id: A0A8M9PXH7
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.

7955:thbs3a
gene id: 7955:thbs3a
uniprot id: Q8JHW2
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen (By similarity).
messages: Belongs to the thrombospondin family.
messages: Expressed both maternally and zygotically. Present at the gastrulation and post-segmentation stages.
messages: Oligomer; disulfide-linked.

7955:ptpn2a
gene id: 7955:ptpn2a
uniprot id: F1Q8I4
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

7955:magi2a
gene id: 7955:magi2a
uniprot id: A0A8M6YX18
uniprot id: A0A8M6YX22
uniprot id: A0A8M6YY10
uniprot id: A0A8M6YY15
uniprot id: A0A8M6YZJ4
uniprot id: A0A8M6Z5C9
uniprot id: A0A8M6Z5D1
uniprot id: A0A8M6Z5Z3
uniprot id: A0A8M9PHB4
uniprot id: F1Q897
names: Subcellular Location Annotation
messages: Membrane

7955:ano2
gene id: 7955:ano2
uniprot id: A0A0R4IKC5
uniprot id: A0A2R8RJ22
uniprot id: A0A8M3ARC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

7955:alox5b.3
gene id: 7955:alox5b.3
uniprot id: F1R442
uniprot id: Q503R7
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:eif2a
gene id: 7955:eif2a
uniprot id: B2GSC5
uniprot id: Q4QRJ7
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

7955:myh11a
gene id: 7955:myh11a
uniprot id: A0A8M9QAD3
uniprot id: A0A8M9QFE6
uniprot id: Q4U0S2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:bcl2l16
gene id: 7955:bcl2l16
uniprot id: A0A8M9PQM8
uniprot id: A0A8M9Q391
uniprot id: D2Y5Q2
names: Similarity
messages: Belongs to the Bcl-2 family.

7955:saal1
gene id: 7955:saal1
uniprot id: Q803M5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAAL1 family.
messages: Nucleus
messages: Plays a role in promoting cell proliferation in response to pro-inflammatory stimuli.

7955:mc2r
gene id: 7955:mc2r
uniprot id: Q7ZTA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

7955:mpdu1a
gene id: 7955:mpdu1a
uniprot id: Q66I07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPDU1 (TC 2.A.43.3) family.
messages: Membrane

7955:onecut3a
gene id: 7955:onecut3a
uniprot id: A0A8N7T7L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

7955:jupa
gene id: 7955:jupa
uniprot id: Q9PVF7
names: Similarity
messages: Belongs to the beta-catenin family.

7955:ntng2b
gene id: 7955:ntng2b
uniprot id: A0A8M3ALV5
uniprot id: A0A8M3AWK1
uniprot id: A0A8M6YUS3
uniprot id: A0A8M9PIL9
uniprot id: A0A8M9PQS8
uniprot id: A0A8M9PUB1
uniprot id: I3IT80
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:atxn1l
gene id: 7955:atxn1l
uniprot id: E7FB74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

7955:phf14
gene id: 7955:phf14
uniprot id: A0A286Y9D1
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Histone-binding protein (PubMed:34365506). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (PubMed:34365506). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity).
messages: Interacts with histone H3.
messages: Nucleus
messages: The N-terminal region, including the PHD-type 1 and 2 zinc fingers and the C2HC pre-PHD-type zinc finger, is required for binding to histone H3.

7955:kdsr
gene id: 7955:kdsr
uniprot id: F1QWW8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:rnaset2
gene id: 7955:rnaset2
uniprot id: A0A8M9PY62
uniprot id: B8XY56
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: AO127 mutants were identified based on increased acridine orange uptake. AO127 mutants display enlarged lysosomes in brain and lysosomal accumulation of undigested ribosomal RNA in brain neurons, white matter lesions adjacent to brain ventricles, and frequent focal white matter anomalies throughout the brain. Nevertheless, mutants appear basically normal, reach normal adult size and length, are fertile and do not display obvious gross motor deficiencies.
messages: Belongs to the RNase T2 family.
messages: Endoplasmic reticulum lumen
messages: Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA.
messages: Lysosome lumen
messages: Secreted
messages: Ubiquitous.

7955:dnase1l1
gene id: 7955:dnase1l1
uniprot id: F1QBE2
uniprot id: Q7SZQ1
names: Similarity
messages: Belongs to the DNase I family.

7955:si:ch1073-159d7.9
gene id: 7955:si:ch1073-159d7.9
uniprot id: F1QTL1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:entpd3
gene id: 7955:entpd3
uniprot id: A0A8M2B467
uniprot id: A4IG37
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

7955:hsd17b3
gene id: 7955:hsd17b3
uniprot id: Q6QA32
uniprot id: Q7T396
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the conversion of 17-oxosteroids to 17beta-hydroxysteroids in the presence of NADPH (PubMed:16216911, PubMed:27927697). Favors the reduction of androstenedione to testosterone (PubMed:16216911, PubMed:27927697). Testosterone is the key androgen driving male development and function (By similarity). Among further tested androgens epiandrosterone and dehydroepiandrosterone are accepted as substrates and reduced at C-17 (PubMed:16216911). Can also reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms (PubMed:16216911, PubMed:27927697). Cannot use androsterone and androstanedione as substrates (PubMed:16216911).
messages: Endoplasmic reticulum
messages: Expressed in embryogenesis from sphere to 84 h post-fertilization.
messages: Expression shows strong sexual dimorphism. In female, highly expressed in ovaries, and at lower levels in skin muscle, eyes and liver (PubMed:16216911). In males, strongly expressed in liver and at lower levels in testis, spleen, kidney, intestine and muscle (PubMed:16216911).
messages: Membrane

7955:spock3
gene id: 7955:spock3
uniprot id: A0A0R4IMY5
uniprot id: A0A8M3BEW5
uniprot id: A0A8M6YZL5
uniprot id: F1RAX3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:magoh
gene id: 7955:magoh
uniprot id: Q566Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mago nashi family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD) (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Nucleus speckle
messages: Part of the EJC core complex that contains casc3, eif4a3, magoh and rbm8a.

7955:pygb
gene id: 7955:pygb
uniprot id: A4IG19
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

7955:gadd45ba
gene id: 7955:gadd45ba
uniprot id: Q6PC51
names: Similarity
messages: Belongs to the GADD45 family.

7955:zgc:110006
gene id: 7955:zgc:110006
uniprot id: Q503Y8
names: Function
names: Similarity
messages: Belongs to the EURL family.
messages: Plays a role in cortical progenitor cell proliferation and differentiation. May promote dendritic spine development of post-migratory cortical projection neurons by modulating the beta-catenin signaling pathway.

7955:rnmt
gene id: 7955:rnmt
uniprot id: Q1MTD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
messages: Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.
messages: Nucleus

7955:zgc:110269
gene id: 7955:zgc:110269
uniprot id: B0UXL7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. Three molecules of fen1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity (By similarity).
messages: Mitochondrion
messages: Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma (By similarity).
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA (By similarity).
messages: nucleolus
messages: nucleoplasm

7955:ovca2
gene id: 7955:ovca2
uniprot id: Q503Y4
names: Similarity
messages: Belongs to the LovG family.

7955:banf1
gene id: 7955:banf1
uniprot id: Q6P026
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BAF family.
messages: Chromosome
messages: Cytoplasm
messages: Has a helix-hairpin-helix (HhH) structural motif conserved among proteins that bind non-specifically to DNA.
messages: Homodimer.
messages: Non-specific DNA-binding protein that plays key roles in mitotic nuclear reassembly, chromatin organization, DNA damage response, gene expression and intrinsic immunity against foreign DNA. Contains two non-specific double-stranded DNA (dsDNA)-binding sites which promote DNA cross-bridging. Plays a key role in nuclear membrane reformation at the end of mitosis by driving formation of a single nucleus in a spindle-independent manner. Transiently cross-bridges anaphase chromosomes via its ability to bridge distant DNA sites, leading to the formation of a dense chromatin network at the chromosome ensemble surface that limits membranes to the surface. Also acts as a negative regulator of innate immune activation by restricting CGAS activity toward self-DNA upon acute loss of nuclear membrane integrity. Outcompetes CGAS for DNA-binding, thereby preventing CGAS activation and subsequent damaging autoinflammatory responses. Also involved in DNA damage response; acts by inhibiting the ADP-ribosyltransferase activity of PARP1. Involved in the recognition of exogenous dsDNA in the cytosol: associates with exogenous dsDNA immediately after its appearance in the cytosol at endosome breakdown and is required to avoid autophagy.
messages: Nucleus
messages: Nucleus envelope

7955:mon1bb
gene id: 7955:mon1bb
uniprot id: E7EY38
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

7955:si:ch1073-272o11.3
gene id: 7955:si:ch1073-272o11.3
uniprot id: E7F704
names: Similarity
messages: Belongs to the CDR2 family.

7955:LOC100004932
gene id: 7955:LOC100004932
uniprot id: A0A8M1PV89
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:rtel1
gene id: 7955:rtel1
uniprot id: F1QNW3
uniprot id: P0C928
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7955:ccdc80
gene id: 7955:ccdc80
uniprot id: Q90X49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC80 family.
messages: Binds to various extracellular matrix proteins.
messages: Promotes cell adhesion and matrix assembly.
messages: extracellular matrix

7955:zgc:92873
gene id: 7955:zgc:92873
uniprot id: A0A8M2BLH3
uniprot id: Q6DGK9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CSTPP1 family.
messages: Expression in elevated in ciliated tissues/organs, including brain, spinal cord, kidney, eyes, ears and lateral line.
messages: Interacts with PCM1. Interacts with the complex TPGC. Binds to alpha-tubulin.
messages: Mutants survive to adulthood and produce offspring (PubMed:34782749). Embryos show a significant defect in heart looping, with an increased proportion of embryos without a looped heart (PubMed:34782749). the They have an increased percentage of ciliated cells and ciliary length in Kupffer's Vesicle, although these alterations are not observed in the ear, pronephros or neural tube (PubMed:34782749).
messages: Regulator of the tubulin polyglutamylase complex (TPGC) that controls cytoskeletal organization, nuclear shape, and cilium disassembly by balancing microtubule and actin assembly. Regulates the assembly and stability of the TPGC and thereby modulates polyglutamylation of the microtubule, which antagonizes MAP4 binding.
messages: centriolar satellite
messages: cytoskeleton

7955:aldh2.1
gene id: 7955:aldh2.1
uniprot id: Q7SXU3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

7955:lmod3
gene id: 7955:lmod3
uniprot id: A0A8M9QA08
uniprot id: E7F7X0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A band
messages: Belongs to the tropomodulin family.
messages: Cytoplasm
messages: Essential for the organization of sarcomeric thin filaments in skeletal muscle.
messages: M line
messages: Morpholino knockdown of the protein causes short bodies, bent tails, and reduced tail birefringence, consistent with abnormal skeletal muscle organization, in fish larvae, 3 days after fertilization. Larvae exhibit reduced trunk size, that generate less force than that of wild-type counterparts, and aberrant accumulation of alpha-actinin. Mutant embryos show abnormal motor function, with reduced spontaneous coiling and diminished touch-evoked escape responses.
messages: cytoskeleton
messages: expressed in muscle (at protein level).

7955:themis
gene id: 7955:themis
uniprot id: A5PF62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the themis family.
messages: Cytoplasm
messages: Nucleus
messages: Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk (By similarity).

7955:f2
gene id: 7955:f2
uniprot id: E7FAN5
uniprot id: Q7SXH8
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

7955:pcdh2ab12
gene id: 7955:pcdh2ab12
uniprot id: Q60I65
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

f3
gene id: 7955:il17a/f3
uniprot id: Q5TKT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

7955:p2rx3b
gene id: 7955:p2rx3b
uniprot id: A0A8M9PCJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

7955:thbs1b
gene id: 7955:thbs1b
uniprot id: F1QEE7
uniprot id: F1QL35
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:chmp6b
gene id: 7955:chmp6b
uniprot id: Q503V0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Endomembrane system
messages: Late endosome membrane
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes (By similarity).
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome (By similarity).

7955:n6amt1
gene id: 7955:n6amt1
uniprot id: Q6DGP3
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

7955:cnnm2a
gene id: 7955:cnnm2a
uniprot id: A2ATX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Cell membrane
messages: Membrane
messages: Metal transporter.

7955:LOC100537538
gene id: 7955:LOC100537538
uniprot id: A0A8M9PL02
names: Cofactor
names: Function
messages: Binds 1 Ca(2+) ion per subunit.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

7955:LOC108191517
gene id: 7955:LOC108191517
uniprot id: A0A8M6Z8X7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:pld1a
gene id: 7955:pld1a
uniprot id: B0V1J1
names: Similarity
messages: Belongs to the phospholipase D family.

7955:LOC101886073
gene id: 7955:LOC101886073
uniprot id: A0A8M2BB89
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:cltcb
gene id: 7955:cltcb
uniprot id: A0A8M2B3J4
uniprot id: A0A8M2B3R2
uniprot id: A0A8M2B4A2
uniprot id: E9QBV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

7955:si:dkey-32n7.4
gene id: 7955:si:dkey-32n7.4
uniprot id: F1QSJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

7955:pcif1
gene id: 7955:pcif1
uniprot id: A0A0R4IKJ1
names: Activity Regulation
names: Caution
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAPAM family.
messages: Cap-specific adenosine methyltransferase activity is inhibited by zinc.
messages: Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs (PubMed:30467178).
messages: Contaminating sequence. Potential poly-A sequence.
messages: Nucleus
messages: The role of N(6),2'-O-dimethyladenosine cap (m6A(m)) on transcripts is unclear and subject to discussion. According to a report, m6A(m) promotes the translation of capped mRNAs (PubMed:30467178). However, another study did not observe a clear effect on mRNA translation, but reported an increased stability of a subset of m6A(m) transcripts (By similarity). According to a third report, m6A(m) inhibits mRNA translation without affecting mRNA stability (By similarity).

7955:tax1bp3
gene id: 7955:tax1bp3
uniprot id: Q8AWD4
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.
messages: Nucleus

7955:adra2a
gene id: 7955:adra2a
uniprot id: Q1L8Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:or121-1
gene id: 7955:or121-1
uniprot id: Q2PRE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:erlin1
gene id: 7955:erlin1
uniprot id: Q58EG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex.

7955:hira
gene id: 7955:hira
uniprot id: A2CEX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

7955:pkd1l2a
gene id: 7955:pkd1l2a
uniprot id: A0A2R8Q5E7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:adgrb3
gene id: 7955:adgrb3
uniprot id: A0A8M1RNS0
uniprot id: A0A8M2B381
uniprot id: A0A8M9QG42
names: Subcellular Location Annotation
messages: Membrane

7955:mmgt1
gene id: 7955:mmgt1
uniprot id: Q6TLE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Component of the ER membrane protein complex (EMC).
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (By similarity). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. May be involved in Mg(2+) transport (By similarity).

7955:sumo1
gene id: 7955:sumo1
uniprot id: Q7SZR5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Cell membrane
messages: Cleavage of precursor form by a sentrin-specific protease is necessary for function.
messages: Cytoplasm
messages: Interacts with sae2, ube2i, ranbp2, pias1 and pias2 (By similarity). Covalently attached to a number of proteins (By similarity).
messages: Nucleus
messages: Nucleus membrane
messages: Nucleus speckle
messages: PML body
messages: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric sumo1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.

7955:adgrl1a
gene id: 7955:adgrl1a
uniprot id: A0A8M9PZN0
uniprot id: F1Q9V2
names: Subcellular Location Annotation
messages: Membrane

7955:LOC792447
gene id: 7955:LOC792447
uniprot id: A0A2R8PWT4
uniprot id: A0A8M9PZP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

7955:gkap1
gene id: 7955:gkap1
uniprot id: Q6NWC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GKAP1 family.
messages: Golgi apparatus
messages: May play a role in the regulation of insulin-dependent IRS1 tyrosine phosphorylation in adipocytes.

7955:khdrbs1a
gene id: 7955:khdrbs1a
uniprot id: A2CE73
uniprot id: Q6NW56
names: Similarity
messages: Belongs to the KHDRBS family.

7955:st6gal1
gene id: 7955:st6gal1
uniprot id: F1QK50
uniprot id: F1QMH5
uniprot id: Q6KB61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

7955:pcnp
gene id: 7955:pcnp
uniprot id: A0A2R8QL91
uniprot id: A0A8M9PPJ7
uniprot id: B8JKH9
uniprot id: B8JKI0
uniprot id: Q5XJC4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with UHRF2/NIRF.
messages: May be involved in cell cycle regulation.
messages: Nucleus

7955:LOC100331460
gene id: 7955:LOC100331460
uniprot id: A0A8M1RLC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:nck2a
gene id: 7955:nck2a
uniprot id: A0A8M9Q4I8
uniprot id: Q803A2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

7955:grin2cb
gene id: 7955:grin2cb
uniprot id: E7FGL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

7955:LOC108182771
gene id: 7955:LOC108182771
uniprot id: A0A8M9Q2X1
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

7955:msx1b
gene id: 7955:msx1b
uniprot id: B2GSG0
uniprot id: Q03356
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Msh homeobox family.
messages: Nucleus
messages: Probable morphogenetic role.

7955:LOC798522
gene id: 7955:LOC798522
uniprot id: A0A8M1PZA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:tlcd1
gene id: 7955:tlcd1
uniprot id: Q5XJP8
names: Subcellular Location Annotation
messages: Membrane

7955:emg1
gene id: 7955:emg1
uniprot id: Q1RM81
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

7955:ints10
gene id: 7955:ints10
uniprot id: A0A8M9PZ30
uniprot id: Q6TNU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 10 family.
messages: Belongs to the multiprotein complex Integrator.
messages: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.
messages: Nucleus

7955:notch1a
gene id: 7955:notch1a
uniprot id: P46530
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Expressed in all cells in pregastrulation stages. During gastrulation is differentially expressed, accumulating predominantly in the prechordal mesoderm and notochord. At the end of gastrulation, expressed along the anterior-posterior axis including the developing neural plate and differentiating mesoderm. Also present in the developing brain and head regions.
messages: Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis (By similarity). Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) (By similarity).
messages: Nucleus
messages: O-glycosylated on the EGF-like domains. Contains both O-linked fucose and O-linked glucose. O-linked glycosylation by galnt11 is involved in determination of left/right symmetry: glycosylation promotes activation of notch1, possibly by promoting cleavage by adam17, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) (By similarity).
messages: Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by adam17 to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). Following endocytosis, this fragment is then cleaved by presenilin dependent gamma-secretase to release a Notch-derived peptide containing the intracellular domain (NICD) from the membrane (By similarity).

7955:actr10
gene id: 7955:actr10
uniprot id: Q7ZVU0
names: Similarity
messages: Belongs to the actin family.

7955:dnaja1
gene id: 7955:dnaja1
uniprot id: Q803K1
names: Subcellular Location Annotation
messages: Membrane

7955:pycard
gene id: 7955:pycard
uniprot id: Q4VBV3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inflammasome

7955:nono
gene id: 7955:nono
uniprot id: A0A8M9PX41
uniprot id: Q802Z5
names: Subcellular Location Annotation
messages: Nucleus speckle

7955:flcn
gene id: 7955:flcn
uniprot id: F1R3E5
uniprot id: Q1RLN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the folliculin family.
messages: Lysosome membrane
messages: Membrane
messages: Nucleus
messages: centrosome
messages: cilium
messages: cytosol
messages: spindle

7955:frrs1a
gene id: 7955:frrs1a
uniprot id: A0A8M9PSX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRRS1 family.
messages: Membrane

7955:dip2bb
gene id: 7955:dip2bb
uniprot id: A0A8M3BAI5
uniprot id: A0A8M9P9C1
uniprot id: A0A8M9PRJ7
uniprot id: A0A8M9PYS4
uniprot id: A0A8M9Q253
names: Similarity
messages: Belongs to the DIP2 family.

7955:rbm17
gene id: 7955:rbm17
uniprot id: A0A8M2BC07
uniprot id: Q7ZVN6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the spliceosome.
messages: Nucleus
messages: Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.

7955:LOC110439882
gene id: 7955:LOC110439882
uniprot id: A0A8M9QGJ2
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

7955:b3gnt9
gene id: 7955:b3gnt9
uniprot id: A0A8M9PD09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:scn4ab
gene id: 7955:scn4ab
uniprot id: A0A2C9F1K3
uniprot id: Q20JQ7
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.4/SCN4A subfamily.
messages: Cell membrane
messages: Channel activity is regulated by ancillary beta subunits. Interaction with a beta subunit is required for rapid channel inactivation and rapid recovery after inactivation, and prevents decrease of channel activity in response to repetitive, high-frequency depolarizations.
messages: Component of a voltage-sensitive sodium channel complex that consists of a pore-forming alpha subunit and one or more regulatory beta subunits.
messages: Expressed in skeletal muscle, heart, brain, spinal cord, and eye.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lacks the cysteine which covalently binds the conotoxin GVIIJ. This cysteine (position 719) is speculated in other sodium channel subunits alpha to be implied in covalent binding with the sodium channel subunit beta-2 or beta-4.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane
messages: Pore-forming subunit of a voltage-gated sodium channel complex through which Na(+) ions pass in accordance with their electrochemical gradient. Alternates between resting, activated and inactivated states. Required for normal muscle fiber excitability, normal muscle contraction and relaxation cycles.
messages: The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.

7955:hyou1
gene id: 7955:hyou1
uniprot id: B2GRZ4
uniprot id: Q7ZUW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Endoplasmic reticulum lumen
messages: Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.

7955:mrpl41
gene id: 7955:mrpl41
uniprot id: B2GSF4
uniprot id: Q502B0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle (By similarity).
messages: Mitochondrion

7955:LOC108179642
gene id: 7955:LOC108179642
uniprot id: A0A8M6YTN9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:slc6a14
gene id: 7955:slc6a14
uniprot id: F6NN04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:arhgap32b
gene id: 7955:arhgap32b
uniprot id: A0A8M3ALJ2
uniprot id: A0A8M3AM92
uniprot id: A0A8M3AWX3
uniprot id: A0A8M3B4R9
uniprot id: A0A8M9PUM5
names: Similarity
messages: Belongs to the PX domain-containing GAP family.

7955:LOC100534786
gene id: 7955:LOC100534786
uniprot id: A0A8M3B3T6
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:col4a3
gene id: 7955:col4a3
uniprot id: A0A8N7TBD4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

7955:rnf175
gene id: 7955:rnf175
uniprot id: A0A8M9P7Z3
uniprot id: B8A5M0
uniprot id: F1QUH4
names: Subcellular Location Annotation
messages: Membrane

7955:tmx2b
gene id: 7955:tmx2b
uniprot id: Q6IQC7
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion membrane
messages: Monomer. Homodimer; disulfide-linked. Occurs in both reduced and oxidized monomeric form. Oxidative conditions increase homodimerization.
messages: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
messages: The thioredoxin domain lacks the 2 redox-active cysteines, suggesting that it lacks thioredoxin activity.

7955:echdc3
gene id: 7955:echdc3
uniprot id: A0PJR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: May play a role in fatty acid biosynthesis and insulin sensitivity.
messages: Mitochondrion

7955:cul4b
gene id: 7955:cul4b
uniprot id: F8W428
names: Similarity
messages: Belongs to the cullin family.

7955:si:dkeyp-118h3.6
gene id: 7955:si:dkeyp-118h3.6
uniprot id: Q32LR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ashwin family.
messages: Nucleus

7955:ugt1a2
gene id: 7955:ugt1a2
uniprot id: F1QM88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7955:LOC567728
gene id: 7955:LOC567728
uniprot id: A0A8M2BF35
uniprot id: A0A8M9QK33
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

7955:gng13b
gene id: 7955:gng13b
uniprot id: Q6DH00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

7955:pym1
gene id: 7955:pym1
uniprot id: Q6PH11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pym family.
messages: Cytoplasm
messages: Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex (By similarity).
messages: Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions (By similarity).
messages: nucleolus
messages: nucleoplasm

7955:pimr173
gene id: 7955:pimr173
uniprot id: A0A8M9Q6B2
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:gnb5a
gene id: 7955:gnb5a
uniprot id: A1L271
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat G protein beta family.
messages: Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, such as RGS7 and RGS9, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (By similarity). Increases RGS7 GTPase-activating protein (GAP) activity, thereby regulating mood and cognition (By similarity). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). Along with gnb5b, plays an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (PubMed:27523599).
messages: May interact with RGS9; this interaction stabilizes both proteins and increases RGS9 GTPase-activating protein (GAP) activity, hence accelerating the deactivation of D(2) dopamine receptor-mediated signaling.
messages: Membrane
messages: No visible phenotype; due to the redundancy with gnb5b. Simultaneous knockout of gnb5a and gnb5b results in no striking dysmorphologic features, but the larvae show impaired swimming activity, remain small, and generally die 7-14 days post fertilization (dpf), most likely as a result of their inability to feed.

7955:cxcl19
gene id: 7955:cxcl19
uniprot id: A9ZPF1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Homodimer.
messages: Secreted

7955:si:ch1073-358c10.1
gene id: 7955:si:ch1073-358c10.1
uniprot id: F1R878
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.

7955:slc29a1a
gene id: 7955:slc29a1a
uniprot id: F1QAM5
uniprot id: Q4V9F6
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Lateral cell membrane
messages: Membrane

7955:trpc6a
gene id: 7955:trpc6a
uniprot id: F1RCY2
uniprot id: Q6ZM90
names: Subcellular Location Annotation
messages: Membrane

7955:avil
gene id: 7955:avil
uniprot id: Q1RLT7
names: Similarity
messages: Belongs to the villin/gelsolin family.

7955:chrnb2b
gene id: 7955:chrnb2b
uniprot id: E7F4S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:si:dkey-28n18.9
gene id: 7955:si:dkey-28n18.9
uniprot id: A0A8M9QGA7
names: Similarity
messages: Belongs to the sorting nexin family.

7955:LOC100536500
gene id: 7955:LOC100536500
uniprot id: A0A8M6Z1E8
uniprot id: A0A8M9PDX5
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:vwc2
gene id: 7955:vwc2
uniprot id: B0I1T8
names: Subcellular Location Annotation
messages: Synapse

7955:kmt2ca
gene id: 7955:kmt2ca
uniprot id: A0A8M2B9D3
uniprot id: A0A8M2B9E0
uniprot id: A0A8M2B9E8
uniprot id: A0A8M2B9Q2
uniprot id: A0A8M6YWB8
uniprot id: A0A8M6YY65
uniprot id: A0A8M9PG96
names: Subcellular Location Annotation
messages: Nucleus

7955:c6ast3
gene id: 7955:c6ast3
uniprot id: Q5BKW6
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC100330650
gene id: 7955:LOC100330650
uniprot id: A0A2R8Q842
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:arid1aa
gene id: 7955:arid1aa
uniprot id: A0A8M9PDQ2
uniprot id: A0A8M9PN46
names: Subcellular Location Annotation
messages: Nucleus

7955:ing5a
gene id: 7955:ing5a
uniprot id: A5WVS7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

7955:ier5
gene id: 7955:ier5
uniprot id: Q90X37
names: Similarity
messages: Belongs to the IER family.

7955:oclna
gene id: 7955:oclna
uniprot id: F1R799
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
messages: Membrane
messages: tight junction

7955:myt1a
gene id: 7955:myt1a
uniprot id: A0A8M3AYN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

7955:LOC108191520
gene id: 7955:LOC108191520
uniprot id: A0A8M6Z8Y1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:LOC795962
gene id: 7955:LOC795962
uniprot id: A0A8M9QHE8
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

7955:paqr4b
gene id: 7955:paqr4b
uniprot id: E7FEU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

7955:ppp1r14bb
gene id: 7955:ppp1r14bb
uniprot id: Q7ZZ37
names: Similarity
messages: Belongs to the PP1 inhibitor family.

7955:serpinb1l2
gene id: 7955:serpinb1l2
uniprot id: Q5RIK7
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

7955:ch25hl1.1
gene id: 7955:ch25hl1.1
uniprot id: Q567X1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family.
messages: Endoplasmic reticulum membrane
messages: May catalyze the formation of 25-hydroxycholesterol from cholesterol.

7955:aadac
gene id: 7955:aadac
uniprot id: E7F2W1
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

7955:baz1b
gene id: 7955:baz1b
uniprot id: A0A8M1P9M0
names: Subcellular Location Annotation
messages: Nucleus

7955:cxcl20
gene id: 7955:cxcl20
uniprot id: A0A8M3B9T3
uniprot id: A9ZPF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

7955:kdm7aa
gene id: 7955:kdm7aa
uniprot id: A0A2R8RKB3
names: Similarity
messages: Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.

7955:pemt
gene id: 7955:pemt
uniprot id: Q7ZVZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

7955:kif11
gene id: 7955:kif11
uniprot id: A0A8M9P014
uniprot id: A0A8M9P8S1
uniprot id: F1QK82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.
messages: spindle pole

7955:si:dkeyp-98a7.1
gene id: 7955:si:dkeyp-98a7.1
uniprot id: A0A8M1NPU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:kdelr2b
gene id: 7955:kdelr2b
uniprot id: Q6PH70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane

7955:mpdu1b
gene id: 7955:mpdu1b
uniprot id: Q6IQH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPDU1 (TC 2.A.43.3) family.
messages: Membrane

7955:si:dkey-56d12.4
gene id: 7955:si:dkey-56d12.4
uniprot id: A4QN70
names: Similarity
messages: Belongs to the HARBI1 family.

7955:LOC100330501
gene id: 7955:LOC100330501
uniprot id: A0A8M3ANQ9
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

7955:ttc19
gene id: 7955:ttc19
uniprot id: A0A8M9QKD1
uniprot id: F1QF34
names: Similarity
messages: Belongs to the TTC19 family.

7955:endou2
gene id: 7955:endou2
uniprot id: B2GQ04
uniprot id: F1RB31
uniprot id: Q503V9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ENDOU family.
messages: Endoribonuclease that cleaves single-stranded RNAs at 5' of uridylates and releases a product with a 2',3'-cyclic phosphate at the 3'-end. The UU and GU sites are more efficiently cleaved than CU and AU sites.
messages: Monomer.

7955:zgc:171713
gene id: 7955:zgc:171713
uniprot id: A0A8M3BE33
uniprot id: A7E2K0
uniprot id: B0QZZ6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:si:rp71-1f1.4
gene id: 7955:si:rp71-1f1.4
uniprot id: Q7T172
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

7955:atp1a1a.2
gene id: 7955:atp1a1a.2
uniprot id: Q9DGL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane

7955:LOC110438218
gene id: 7955:LOC110438218
uniprot id: A0A8M9PIK3
names: Similarity
messages: Belongs to the NLRP family.

7955:mrpl54
gene id: 7955:mrpl54
uniprot id: Q1LXI5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

7955:cdc42ep4a
gene id: 7955:cdc42ep4a
uniprot id: Q6GMK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

7955:tob1b
gene id: 7955:tob1b
uniprot id: Q7SZP8
names: Similarity
messages: Belongs to the BTG family.

7955:tbx20
gene id: 7955:tbx20
uniprot id: A0A8M9PJM0
uniprot id: B3DJG4
uniprot id: Q9I9K7
names: Caution
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: During development, expressed in embryonic structures of both mesodermal and ectodermal origins, including the heart, cranial motor neurons and the roof of the dorsal aorta. Prominently associated with heart formation and continuously expressed in the myocardial lineage from the initiation of myocardial differentiation through to formation of the differentiated, two chambered heart. First detected in anterior lateral plate mesoderm (ALPM) and by the 5- to 10-somite stages, strongly expressed in ALPM and in two bilateral groups of mesenchymal cells close to the anterior notochord and in a crescent of lateral plate adjacent to the tail. At the 6- to 8- and 12- to 14-somite stages, expressed throughout the ALPM. Between the 10 and 15-somite stages, expressed throughout the myocardium. At the 18-somite stage, expressed in the loosely packed mesenchymal cells in the midline immediately anterior to the heart fields. Later expression seen in the cardiac cone, cardiac tube and ventricle.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Transcriptional regulator that may play a very early role in the differentiation of the cardiac precursors.

7955:LOC100333474
gene id: 7955:LOC100333474
uniprot id: A0A8M6YZ59
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

7955:jph3
gene id: 7955:jph3
uniprot id: A0A0R4IT36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

7955:dpys
gene id: 7955:dpys
uniprot id: B1H1J6
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

7955:si:dkey-17e16.10
gene id: 7955:si:dkey-17e16.10
uniprot id: E7F8G8
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

7955:crygm7
gene id: 7955:crygm7
uniprot id: Q5XTN3
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:si:dkey-3n22.9
gene id: 7955:si:dkey-3n22.9
uniprot id: A0A8M9P2A8
names: Similarity
messages: Belongs to the peptidase C48 family.

7955:hbegfb
gene id: 7955:hbegfb
uniprot id: A0A8M1NE67
uniprot id: A0A8M2B880
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:spsb4a
gene id: 7955:spsb4a
uniprot id: B0S5W3
names: Similarity
messages: Belongs to the SPSB family.

7955:taar12b
gene id: 7955:taar12b
uniprot id: Q5QNQ3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:LOC558300
gene id: 7955:LOC558300
uniprot id: A0A8M9PBG8
uniprot id: A0A8N7TEP3
names: Subcellular Location Annotation
messages: Cytoplasm

7955:dmrt3a
gene id: 7955:dmrt3a
uniprot id: P83758
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the DMRT family.
messages: Expressed in the developing germ cells of both gonads, mainly in spermatogonia, spermatocytes and developing oocytes. Also expressed in embryonic olfactory placode and neural tube.
messages: Expression increases gradually to a high level at pharyngula stage, which is restricted to the olfactory placode and the neural tube. In the juvenile zebrafish, the expression is first detected in undifferentiated gonad on 17 dpf.
messages: Nucleus
messages: Probable transcription factor that plays a role in configuring the spinal circuits controlling motion in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling movements. May regulate transcription (By similarity).

7955:ttk
gene id: 7955:ttk
uniprot id: Q8AYG3
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Tissue Specificity
messages: Barely detectable in adult somatic tissues. Expressed in immature germ cells that have not completed meiosis. In ovary, expressed predominantly in previtellogenic oocytes. In testis, expressed in primary and secondary spermatocytes, but not mature spermatozoa.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Mutants show anomalies in the chromosome number of male germ cells, leading to aneuploidy and severe developmental defects in their progeny.
messages: Phosphorylates proteins on serine, threonine, and tyrosine (By similarity). Involved in mitotic cell cycle checkpoint control. Required for fin and heart regeneration. Required to prevent chromosome segregation errors during meiosis.
messages: Strongly induced in a subpopulation of cells in the proximal blastema during regenerative outgrowth.

7955:cldnj
gene id: 7955:cldnj
uniprot id: A0A8N7UZN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

7955:slc4a11
gene id: 7955:slc4a11
uniprot id: A0A8M1NRH1
uniprot id: A0A8M2B2N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Membrane

7955:kank2
gene id: 7955:kank2
uniprot id: X1WE18
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in different biological processes including transcription and apoptosis by sequestering specific proteins outside of the nucleus (By similarity). Involved in actin stress fibers formation probably through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (By similarity). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457).
messages: Mitochondrion
messages: Morpholino knockdown of the protein results in an edematous phenotype and proteinuria (PubMed:25961457). Podocyte foot process effacement and disorganization, rarefaction of slit membranes, and disorganization of the glomerular basement membrane in glomeruli which are characteritic of nephrosis are observed (PubMed:25961457).

7955:midn
gene id: 7955:midn
uniprot id: A0A8M2BHR6
uniprot id: A0A8M2BHR8
uniprot id: Q6NYU6
names: Function
names: Subcellular Location Annotation
messages: Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.
messages: Nucleus
messages: cytosol
messages: nucleolus

7955:crygm4
gene id: 7955:crygm4
uniprot id: Q5XTN5
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:kcnj1a.5
gene id: 7955:kcnj1a.5
uniprot id: Q1L8I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

7955:mrs2
gene id: 7955:mrs2
uniprot id: A0A8M9PDH1
uniprot id: E7F680
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mitochondrion inner membrane

7955:abca2
gene id: 7955:abca2
uniprot id: A0A8M2BCG2
uniprot id: A0A8M2BCH1
uniprot id: A0A8M2BCJ8
names: Subcellular Location Annotation
messages: Membrane

7955:hs3st2
gene id: 7955:hs3st2
uniprot id: A0MGY7
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

7955:rxfp2b
gene id: 7955:rxfp2b
uniprot id: F8W5N7
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:rev1
gene id: 7955:rev1
uniprot id: A0A8M2BF27
uniprot id: A0A8M3AVZ1
uniprot id: A0A8M6Z8G9
uniprot id: B0UY97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-Y family.
messages: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
messages: Nucleus

7955:ddx51
gene id: 7955:ddx51
uniprot id: Q6DRI7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits.
messages: Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

7955:stab1
gene id: 7955:stab1
uniprot id: E0CZJ3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:asah2
gene id: 7955:asah2
uniprot id: Q5W7F1
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the neutral ceramidase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Detected in intestine (at protein level).
messages: Expressed and active during embryonic development.
messages: Fishes display severe embryonic morphological and cellular abnormalities such as abnormal morphogenesis in the head and tail, pericardial edema, defect of blood cell circulation, and an increase of apoptotic cells, especially in the head and neural tube regions, at 36 hours post-fertilization.
messages: Golgi apparatus membrane
messages: Membrane raft
messages: Mitochondrion
messages: N-glycosylated.
messages: O-glycosylated.
messages: Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH (PubMed:15271994). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine. Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells (By similarity). Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1-phosphate inside and outside cells (By similarity).
messages: caveola
messages: extracellular exosome

7955:si:ch1073-157b13.1
gene id: 7955:si:ch1073-157b13.1
uniprot id: F1R4M0
names: Similarity
messages: Belongs to the methyltransferase superfamily.

7955:nt5dc2
gene id: 7955:nt5dc2
uniprot id: Q08C96
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

7955:entpd2b
gene id: 7955:entpd2b
uniprot id: A0A8M3AWQ3
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

7955:LOC101884509
gene id: 7955:LOC101884509
uniprot id: A0A8M9Q5N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

7955:si:dkey-81e3.1
gene id: 7955:si:dkey-81e3.1
uniprot id: K7DY59
names: Similarity
messages: Belongs to the DOCK family.

7955:LOC110439859
gene id: 7955:LOC110439859
uniprot id: A0A8M9QFP7
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

7955:ppp1r2
gene id: 7955:ppp1r2
uniprot id: Q6P0J0
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

7955:ptprna
gene id: 7955:ptprna
uniprot id: A0A8M6Z8D6
uniprot id: F1R8X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
messages: Membrane
messages: secretory vesicle membrane

7955:asun
gene id: 7955:asun
uniprot id: A0A8M6Z599
uniprot id: Q7ZVZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the asunder family.
messages: Cytoplasm
messages: Nucleus

7955:cpox
gene id: 7955:cpox
uniprot id: Q05AK3
names: Similarity
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Homodimer.

7955:polr1e
gene id: 7955:polr1e
uniprot id: Q501W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

7955:uqcrb
gene id: 7955:uqcrb
uniprot id: Q4VBV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

7955:cyb561a3a
gene id: 7955:cyb561a3a
uniprot id: A0A8M2BJJ7
uniprot id: A3KPR5
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds 2 heme b groups non-covalently.
messages: Homodimer.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome. Reduced iron can then be extruded from the late endosome and lysosome to the cytoplasm by divalent metal-specific transporters. It is therefore most probably involved in endosomal and lysosomal cellular iron homeostasis.

7955:rps24
gene id: 7955:rps24
uniprot id: A0A8M2B343
uniprot id: A0A8M9PXR0
uniprot id: B7ZD34
uniprot id: Q642J7
uniprot id: Q6TEN7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

7955:tlx2
gene id: 7955:tlx2
uniprot id: A0A2R8QHC0
uniprot id: A1A5U3
names: Subcellular Location Annotation
messages: Nucleus

7955:b3gnt2l
gene id: 7955:b3gnt2l
uniprot id: A0A8M9PMP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:tbx2a
gene id: 7955:tbx2a
uniprot id: A0A8M2BCU2
uniprot id: B0R122
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7955:tmem181
gene id: 7955:tmem181
uniprot id: A0A0R4IYB4
uniprot id: A0A8M2BFT6
uniprot id: F1QYZ0
names: Subcellular Location Annotation
messages: Membrane

7955:nup93
gene id: 7955:nup93
uniprot id: A0A8M3AKC1
uniprot id: B2GRL6
uniprot id: Q1LV08
uniprot id: Q7ZU29
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: Mutants can be recognized on day 2 of embryogenesis by the presence of necrotic cells in the tectum and eyes. Dye mutants die on day 5 of development.
messages: Nucleus membrane
messages: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.
messages: nuclear pore complex

7955:atp6v1f
gene id: 7955:atp6v1f
uniprot id: Q6DRK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase F subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

7955:il15l
gene id: 7955:il15l
uniprot id: A0A0R4IKC3
uniprot id: A0A8M3ASP6
uniprot id: B3DFL4
uniprot id: F1QRP5
uniprot id: Q32PM5
uniprot id: Q5W7F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

7955:polr3c
gene id: 7955:polr3c
uniprot id: Q7ZUX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (By similarity).
messages: Nucleus

7955:adgre5b.3
gene id: 7955:adgre5b.3
uniprot id: A0A8M2B717
uniprot id: A0A8M2B737
uniprot id: A0A8M3AUF2
uniprot id: A0A8M6Z098
uniprot id: A0A8M9PWR5
uniprot id: A0A8M9Q2I5
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:xrcc6bp1
gene id: 7955:xrcc6bp1
uniprot id: A4IGF3
names: Similarity
messages: Belongs to the peptidase M76 family.

7955:capn10
gene id: 7955:capn10
uniprot id: A0A8N7UW33
names: Similarity
messages: Belongs to the peptidase C2 family.

7955:larp7
gene id: 7955:larp7
uniprot id: E7F7F2
uniprot id: Q7ZWE3
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LARP7 family.
messages: Core component of the 7SK RNP complex. Associates with box C/D small nucleolar ribonucleoprotein (snoRNP) complexes.
messages: Expression reaches a peak at 48 hours post-fertilization (hpf) and then decreases at 72, 96 and 120 hpf (PubMed:26542022). In embryonic hearts, expression slightly increases between 48 and 96 hpf, and then decreases at 120 hpf (PubMed:26542022). Expressed in the adult heart (PubMed:26542022).
messages: Mild cardiac phenotype with increased phosphorylation of 'Ser-2' on RNA polymerase II.
messages: RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:26542022). Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (PubMed:26542022). The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:26542022). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (By similarity). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (By similarity). LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing. Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (By similarity). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (By similarity).
messages: The xRRM domain binds the 3' end of 7SK snRNA (7SK RNA) at the top of stem-loop 4.
messages: nucleoplasm

7955:swi5
gene id: 7955:swi5
uniprot id: E7FF22
names: Function
names: Similarity
messages: Belongs to the SWI5/SAE3 family.
messages: Component of the swi5-sfr1 complex, a complex required for double-strand break repair via homologous recombination.

7955:mif4gdb
gene id: 7955:mif4gdb
uniprot id: Q5EAQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MIF4GD family.
messages: Cytoplasm
messages: Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation (By similarity).
messages: Interacts with eif4g1, eif4g2 and slbp; probably tethered by SLBP to the 3'-end of mRNAs ending with the histone stem-loop, it also interacts with eif4g1 which is bound to their 5'-end.
messages: Nucleus

7955:acot22
gene id: 7955:acot22
uniprot id: A0A8M1NZE7
uniprot id: Q6GMJ5
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

7955:gpd2
gene id: 7955:gpd2
uniprot id: A0A8M2BDB8
uniprot id: F1Q555
uniprot id: Q0P3X1
names: Function
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device.

7955:ndufaf1
gene id: 7955:ndufaf1
uniprot id: Q5CZW0
names: Function
names: Similarity
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the CIA30 family.

7955:pqlc1
gene id: 7955:pqlc1
uniprot id: A0A2R8QPC7
uniprot id: A0A8M9PH02
names: Subcellular Location Annotation
messages: Membrane

7955:mpz
gene id: 7955:mpz
uniprot id: A0A0R4IS04
uniprot id: A0A2R8QN30
uniprot id: A0A8M6Z0S2
uniprot id: Q8JFG6
names: Subcellular Location Annotation
messages: Membrane

7955:LOC108179113
gene id: 7955:LOC108179113
uniprot id: A0A8M6YXI7
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:nr4a2a
gene id: 7955:nr4a2a
uniprot id: A0A2R9YJF7
uniprot id: A9Q8C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Nucleus

7955:entpd5b
gene id: 7955:entpd5b
uniprot id: E9QI88
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

7955:rbm47
gene id: 7955:rbm47
uniprot id: A0A8M1NHK4
uniprot id: A0A8M2BFN4
uniprot id: A0A8M9PVG8
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM RBM47 family.
messages: Cytoplasm
messages: Homodimer (By similarity). May interact with MAVS; may regulate MAVS lysosomal degradation (PubMed:32859727).
messages: Morpholino knockdown of the protein prevents head development.
messages: Nucleus
messages: Single-stranded RNA-binding protein that functions in a variety of RNA processes, including alternative splicing, RNA stabilization, and RNA editing (By similarity). Independently of its RNA-binding activity, could negatively regulate MAVS by promoting its lysosomal degradation (PubMed:32859727).
messages: The RRM domains are required for mRNA stabilization (By similarity). The RRM domains mediate interaction with MAVS (PubMed:32859727).
messages: Up-regulated upon viral infection.

7955:paqr5a
gene id: 7955:paqr5a
uniprot id: Q7ZVH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane
messages: Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation (By similarity).

7955:bpgm
gene id: 7955:bpgm
uniprot id: Q6DHM0
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

7955:ston1
gene id: 7955:ston1
uniprot id: F1R8F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Stoned B family.
messages: Cytoplasm

7955:ttc9
gene id: 7955:ttc9
uniprot id: A0A8N7TAX5
names: Similarity
messages: Belongs to the TTC9 family.

7955:bmp7a
gene id: 7955:bmp7a
uniprot id: Q9PTF9
names: Similarity
messages: Belongs to the TGF-beta family.

7955:coq9
gene id: 7955:coq9
uniprot id: A5PLI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ9 family.
messages: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
messages: Mitochondrion

7955:si:dkey-261m9.7
gene id: 7955:si:dkey-261m9.7
uniprot id: Q561S9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:polr2k
gene id: 7955:polr2k
uniprot id: A7E2K9
uniprot id: F1RDV9
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

7955:gclc
gene id: 7955:gclc
uniprot id: Q6NV35
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

7955:lsm12b
gene id: 7955:lsm12b
uniprot id: Q6PBA2
names: Similarity
messages: Belongs to the LSM12 family.

7955:taldo1
gene id: 7955:taldo1
uniprot id: Q6P6Y0
names: Function
names: Similarity
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.

7955:diablob
gene id: 7955:diablob
uniprot id: A0A8M1NZ47
uniprot id: A7E270
names: Subcellular Location Annotation
messages: Mitochondrion

7955:tmem86b
gene id: 7955:tmem86b
uniprot id: F1QLP0
uniprot id: Q0P4C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

7955:atp1a1a.5
gene id: 7955:atp1a1a.5
uniprot id: Q8JIV1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:megf10
gene id: 7955:megf10
uniprot id: A0A8M1QV85
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:si:dkey-21e13.3
gene id: 7955:si:dkey-21e13.3
uniprot id: A0A8M2B388
uniprot id: U3JAI0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Mitochondrion

7955:fer
gene id: 7955:fer
uniprot id: A0A8M3ASR9
uniprot id: A0A8M9Q1U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: cytoskeleton

7955:foxd1
gene id: 7955:foxd1
uniprot id: A2CE80
names: Subcellular Location Annotation
messages: Nucleus

7955:LOC100001596
gene id: 7955:LOC100001596
uniprot id: A0A8M6Z4G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

7955:arl5c
gene id: 7955:arl5c
uniprot id: Q6P6E8
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

7955:LOC100334818
gene id: 7955:LOC100334818
uniprot id: F1QYH9
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

7955:pygmb
gene id: 7955:pygmb
uniprot id: E7EXT3
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

7955:agtr1b
gene id: 7955:agtr1b
uniprot id: E7FEQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C.

7955:zgc:172079
gene id: 7955:zgc:172079
uniprot id: A9UL52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

7955:plekha7a
gene id: 7955:plekha7a
uniprot id: B6RSP1
names: Function
names: Subcellular Location Annotation
messages: Required for zonula adherens biogenesis and maintenance.
messages: adherens junction
messages: centrosome

7955:pimr214
gene id: 7955:pimr214
uniprot id: A0A8M3ARC8
uniprot id: A0A8M9Q121
uniprot id: A0A8M9QBU5
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.

7955:si:dkey-283b1.7
gene id: 7955:si:dkey-283b1.7
uniprot id: E7F8B1
names: Subcellular Location Annotation
messages: Synapse

7955:ank2a
gene id: 7955:ank2a
uniprot id: A0A8M9PJQ6
uniprot id: A0A8M9PJS2
uniprot id: A0A8M9PX50
uniprot id: A0A8M9PX61
uniprot id: A0A8M9PX68
uniprot id: A0A8M9Q2X9
uniprot id: A0A8M9Q2Z7
uniprot id: A0A8M9Q892
uniprot id: A0A8M9Q8A0
uniprot id: A0A8M9QDJ9
uniprot id: A0A8M9QDK6
uniprot id: A0A8M9QDL1
uniprot id: A0A8M9QDL7
uniprot id: A0A8M9QDM2
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

7955:lsm7
gene id: 7955:lsm7
uniprot id: A4FVI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

7955:zgc:101765
gene id: 7955:zgc:101765
uniprot id: Q5XJM7
names: Similarity
messages: Belongs to the aldo/keto reductase family.

7955:bloc1s6
gene id: 7955:bloc1s6
uniprot id: E9QGH2
names: Function
names: Similarity
messages: Belongs to the BLOC1S6 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.

7955:polb
gene id: 7955:polb
uniprot id: B0R194
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Cytoplasm
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus

7955:cdc34b
gene id: 7955:cdc34b
uniprot id: Q6DG18
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7955:zgc:162816
gene id: 7955:zgc:162816
uniprot id: A0A8M3BDT3
names: Similarity
messages: Belongs to the DSD1 family.

7955:eps8l3b
gene id: 7955:eps8l3b
uniprot id: A0A8M2BF07
uniprot id: B8JIS3
names: Similarity
messages: Belongs to the EPS8 family.

7955:si:dkey-7f3.9
gene id: 7955:si:dkey-7f3.9
uniprot id: A0A0R4IZW2
uniprot id: A0A8M3AI29
uniprot id: A0A8M3AQK4
names: Similarity
messages: Belongs to the ENTREP family.

7955:LOC101885464
gene id: 7955:LOC101885464
uniprot id: A0A8M2B780
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

7955:cldn7a
gene id: 7955:cldn7a
uniprot id: Q6DHP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space.
messages: tight junction

7955:zgc:110283
gene id: 7955:zgc:110283
uniprot id: A0A8M9PK36
uniprot id: A0A8M9Q8L1
uniprot id: Q568I4
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

7955:LOC100538037
gene id: 7955:LOC100538037
uniprot id: A0A8M3B656
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:rnpep
gene id: 7955:rnpep
uniprot id: A0A8M2BGI7
uniprot id: Q6DGD8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

7955:LOC101882681
gene id: 7955:LOC101882681
uniprot id: A0A8M9Q7W6
uniprot id: A0A8M9QDT8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:syne1a
gene id: 7955:syne1a
uniprot id: A0A8M9PC75
uniprot id: A0A8M9PHU3
names: Similarity
messages: Belongs to the nesprin family.

7955:b9d1
gene id: 7955:b9d1
uniprot id: Q503B7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the B9D family.
messages: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).
messages: Part of the tectonic-like complex (also named B9 complex).
messages: cilium basal body

7955:LOC110438068
gene id: 7955:LOC110438068
uniprot id: A0A8M9P0W3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer of an alpha and a beta chain.
messages: Secreted

7955:il17c
gene id: 7955:il17c
uniprot id: Q5TKT2
names: Similarity
messages: Belongs to the IL-17 family.

7955:alg12
gene id: 7955:alg12
uniprot id: A5PLJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:snx5
gene id: 7955:snx5
uniprot id: Q803H8
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

7955:sft2d3
gene id: 7955:sft2d3
uniprot id: X1WFG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

7955:LOC101883651
gene id: 7955:LOC101883651
uniprot id: A0A8M9P2I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

7955:tcf7l1a
gene id: 7955:tcf7l1a
uniprot id: Q9YHE8
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCF/LEF family.
messages: By ctnnb1.
messages: Expressed maternally and throughout embryogenesis. Expressed in the dorsal mesoderm at 6 hours post fertilization (6 hpf), and this expression is maintained in the axial mesoderm during gastrulation and early somitogenesis. Strongly expressed in the prospective neuroectoderm at 8 hpf. Expression persists in the neuroectoderm and increases in the tail bud at the end of gastrulation, at 10 hpf. Enriched in the prechordal mesoderm and developing notochord and in ventromedial regions of the brain and neural tube during the early somite stages. Expression remains elevated within the tail bud, forebrain, the midbrain-hindbrain boundary and in the developing otic vesicles as somitogenesis progresses.
messages: Interacts with tle3a/gro2.
messages: Nucleus
messages: Participates in the Wnt signaling pathway. Probably binds to DNA and acts as a repressor in the absence of ctnnb1, and possibly as an activator in its presence. Required early in development for dorsal specific gene activation and during gastrulation for repression of dorsal-specific genes in the marginal zone. Required for head formation and forebrain specification. Regulates anterior-posterior patterning in the neuroectoderm by repressing posterior neural fates.

7955:gabrr1
gene id: 7955:gabrr1
uniprot id: A0A8M2B753
uniprot id: Q5TZ16
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:LOC100331324
gene id: 7955:LOC100331324
uniprot id: E7F386
names: Similarity
messages: Belongs to the peptidase C14A family.

7955:zgc:56676
gene id: 7955:zgc:56676
uniprot id: Q7ZW93
names: Similarity
messages: Belongs to the SUI1 family.

7955:zgc:175280
gene id: 7955:zgc:175280
uniprot id: A9JTI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

7955:LOC100149676
gene id: 7955:LOC100149676
uniprot id: A0A8M3AX74
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:vti1b
gene id: 7955:vti1b
uniprot id: Q7SY45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

7955:nr6a1a
gene id: 7955:nr6a1a
uniprot id: B3DH62
uniprot id: Q9PU65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family.
messages: Belongs to the nuclear hormone receptor family. NR6 subfamily.
messages: Expressed in germ cells, being predominant in previtellogenic oocytes in the ovary and in spermatocytes in the testis.
messages: Homodimer.
messages: Nucleus
messages: Probable orphan nuclear receptor. Binds to a response element containing repeats of the motif 5'-AGGTCA-3' (By similarity).

7955:fam3c
gene id: 7955:fam3c
uniprot id: B2GRJ9
uniprot id: Q7ZYY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Involved in retinal laminar formation.
messages: Secreted

7955:fam212b
gene id: 7955:fam212b
uniprot id: A0A0R4IZE7
uniprot id: A0A8M3BBT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

7955:LOC107980443
gene id: 7955:LOC107980443
uniprot id: F1QVT2
names: Similarity
messages: Belongs to the apolipoprotein L family.

7955:exosc2
gene id: 7955:exosc2
uniprot id: F8W3K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP4 family.
messages: Cytoplasm

7955:aspdh
gene id: 7955:aspdh
uniprot id: A0A8M9PUP6
uniprot id: Q66I59
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.

7955:nrxn3b
gene id: 7955:nrxn3b
uniprot id: A1XQY1
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: After the very early developmental stages, the expression levels decrease and remain relatively constant until around 24 h, with the onset of an increase of expression that continues till the larval stages.
messages: Belongs to the neurexin family.
messages: Membrane
messages: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.
messages: Produced by alternative splicing.

7955:smyhc1
gene id: 7955:smyhc1
uniprot id: A0A0R4INI3
uniprot id: Q508P8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:mmp14b
gene id: 7955:mmp14b
uniprot id: B0R0I1
uniprot id: Q7T2J1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

7955:dlb
gene id: 7955:dlb
uniprot id: O57409
uniprot id: Q1LYD2
names: Caution
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation.
messages: Expressed in the epiblast (the future neurectoderm) and in neuroblasts. Expressed in overlapping regions with deltaA (dla) and deltaD (dld), but differs in the neural plate: it is apparently confined to the scattered cells within those patches that differentiate as neurons, while dla and dld are expressed in patches of contiguous cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.
messages: Ubiquitinated by mib, leading to its endocytosis and subsequent degradation.

7955:kat6a
gene id: 7955:kat6a
uniprot id: A2CG09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

7955:dync1i2a
gene id: 7955:dync1i2a
uniprot id: A0A286YAG4
uniprot id: A0A8M6Z827
names: Similarity
messages: Belongs to the dynein intermediate chain family.

7955:aamdc
gene id: 7955:aamdc
uniprot id: Q502H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAMDC family.
messages: Cytoplasm

7955:or115-5
gene id: 7955:or115-5
uniprot id: Q2PRH7
names: Subcellular Location Annotation
messages: Membrane

7955:setdb1b
gene id: 7955:setdb1b
uniprot id: A0A0R4IUW4
uniprot id: A0A8M1NBP0
uniprot id: A0A8M2B4Z0
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

7955:adamts17
gene id: 7955:adamts17
uniprot id: A0A8M9QHG7
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

7955:zgc:114130
gene id: 7955:zgc:114130
uniprot id: F1QH59
uniprot id: Q4V8V0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

7955:evx2
gene id: 7955:evx2
uniprot id: Q6PFR9
names: Subcellular Location Annotation
messages: Nucleus

7955:pak1ip1
gene id: 7955:pak1ip1
uniprot id: Q6TNS2
names: Function
names: Subcellular Location Annotation
messages: Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.
messages: nucleolus

7955:unc5da
gene id: 7955:unc5da
uniprot id: A0A0R4IEH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

7955:trim105
gene id: 7955:trim105
uniprot id: A0A8M2B3Z9
uniprot id: A0A8M9QKG1
uniprot id: B3DGU9
names: Subcellular Location Annotation
messages: Cytoplasm

7955:trim35-14
gene id: 7955:trim35-14
uniprot id: A0A8M1PZV1
names: Subcellular Location Annotation
messages: Cytoplasm

7955:LOC101885083
gene id: 7955:LOC101885083
uniprot id: A0A8M9NZW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

7955:arhgap33
gene id: 7955:arhgap33
uniprot id: A0A8M2B4S4
uniprot id: A0A8M2B4T5
uniprot id: A0A8M2B593
uniprot id: A0A8M2B5A9
uniprot id: A0A8N7UW30
names: Similarity
messages: Belongs to the PX domain-containing GAP family.

7955:ctsla
gene id: 7955:ctsla
uniprot id: A0A8M2BCJ2
uniprot id: A5WVL6
uniprot id: Q6NYR5
names: Similarity
messages: Belongs to the peptidase C1 family.

7955:plaa
gene id: 7955:plaa
uniprot id: Q7SXM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PLAP family.
messages: Cytoplasm

7955:jmjd1ca
gene id: 7955:jmjd1ca
uniprot id: A0A8M9PPN0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM2 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
messages: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
messages: Nucleus
messages: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.

7955:higd1a
gene id: 7955:higd1a
uniprot id: Q7ZZZ4
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

7955:ND6
gene id: 7955:ND6
uniprot id: A0A0A0VG13
uniprot id: Q9MIX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 6 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

7955:keap1b
gene id: 7955:keap1b
uniprot id: A0A2R8Q1W5
uniprot id: A0A8M9Q5W8
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the KEAP1 family.
messages: Cytoplasm
messages: Homodimer and heterodimer; heterodimerizes with keap1a (PubMed:18057000). Component of the BCR(KEAP1) E3 ubiquitin ligase complex, at least composed of 2 molecules of cul3, 2 molecules of keap1 (keap1a and/or keap1b), and rbx1 (By similarity). Interacts with nfe2l2/nrf2; the interaction is direct (By similarity).
messages: Keap1 contains reactive cysteine residues that act as sensors for endogenously produced and exogenously encountered small molecules, which react with sulfhydryl groups and modify the cysteine sensors, leading to impair ability of the BCR(KEAP1) complex to ubiquitinate target proteins.
messages: Non-enzymatic covalent modifications of reactive cysteines by electrophile metabolites inactivate the BCR(KEAP1) complex.
messages: Nucleus
messages: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting nfe2l2/nrf2 for ubiquitination (PubMed:18057000). Keap1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of nfe2l2/nrf2, a transcription factor regulating expression of many cytoprotective genes (PubMed:18057000). In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting nfe2l2/nrf2 nuclear accumulation and expression of phase II detoxifying enzymes (By similarity).
messages: Ubiquitin ligase activity of the BCR(KEAP1) complex is inhibited by oxidative stress and electrophile metabolites such as sulforaphane. Electrophile metabolites react with reactive cysteine residues in keap1 and trigger non-enzymatic covalent modifications of these cysteine residues, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex.
messages: Widely expressed.

7955:elovl4a
gene id: 7955:elovl4a
uniprot id: Q6PBM2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL4 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Oligomer.

7955:taar19c
gene id: 7955:taar19c
uniprot id: A0A2R8QAB2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:eif2b1
gene id: 7955:eif2b1
uniprot id: A0A0R4ILD9
uniprot id: Q6IQQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.
messages: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
messages: Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

7955:cenpi
gene id: 7955:cenpi
uniprot id: F1QJK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-I/CTF3 family.
messages: Nucleus
messages: centromere

7955:LOC100005266
gene id: 7955:LOC100005266
uniprot id: A0A8M3B4W9
names: Similarity
messages: Belongs to the peptidase C13 family.

7955:pon3.2
gene id: 7955:pon3.2
uniprot id: F1R1X3
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

7955:wu:fa26c03
gene id: 7955:wu:fa26c03
uniprot id: A7MCR7
names: Similarity
messages: Belongs to the peptidase C1 family.

7955:nipal2
gene id: 7955:nipal2
uniprot id: A0A8M6YTR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

7955:cyp4f3
gene id: 7955:cyp4f3
uniprot id: A3KP35
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:glis2b
gene id: 7955:glis2b
uniprot id: A0A0R4IE83
uniprot id: T1WQU8
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

7955:hrasa
gene id: 7955:hrasa
uniprot id: Q568K0
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

7955:oxct1b
gene id: 7955:oxct1b
uniprot id: Q08CC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
messages: Mitochondrion

7955:crata
gene id: 7955:crata
uniprot id: Q642H6
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

7955:picalma
gene id: 7955:picalma
uniprot id: A0A8M3AWT2
uniprot id: A0A8M3AWV7
uniprot id: A0A8M3AWV9
uniprot id: A0A8M3B3B4
uniprot id: A0A8M3B3B6
uniprot id: A0A8M3B694
uniprot id: A0A8M3B698
uniprot id: A0A8M3BD23
uniprot id: A0A8M9PTF3
uniprot id: A0A8M9PTF8
uniprot id: A0A8M9PTG3
uniprot id: A0A8M9Q5T5
uniprot id: A0A8M9Q5T8
uniprot id: A0A8M9Q5U0
uniprot id: A0A8M9Q5U3
uniprot id: A0A8M9QBW1
uniprot id: A0A8M9QBW5
uniprot id: A0A8M9QBX0
uniprot id: A0A8M9QGF6
uniprot id: A0A8M9QGG0
uniprot id: A0A8M9QGG5
uniprot id: A0A8M9QKK5
uniprot id: A0A8M9QKL0
uniprot id: A0A8M9QKL4
uniprot id: F1QKW9
uniprot id: Q7ZVU6
names: Similarity
messages: Belongs to the PICALM/SNAP91 family.

7955:bcar1
gene id: 7955:bcar1
uniprot id: A0A2R8Q9D0
uniprot id: A0A2R8QJQ5
uniprot id: A0A8M9PM80
uniprot id: B5DE36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

7955:LOC100005038
gene id: 7955:LOC100005038
uniprot id: A0A8M9PXP1
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

7955:reep1
gene id: 7955:reep1
uniprot id: A0A8M9P9M3
uniprot id: F8W555
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:tsen2
gene id: 7955:tsen2
uniprot id: Q08BW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

7955:si:ch211-252f13.5
gene id: 7955:si:ch211-252f13.5
uniprot id: X1WBF6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:gab1
gene id: 7955:gab1
uniprot id: A0A8M6YUV9
uniprot id: A0A8M6YVD8
uniprot id: A0A8M9P5A1
uniprot id: A0A8M9PTD5
uniprot id: F1Q7S5
uniprot id: F6NTT0
names: Similarity
messages: Belongs to the GAB family.

7955:ifng1-2
gene id: 7955:ifng1-2
uniprot id: Q75S22
names: Similarity
messages: Belongs to the type II (or gamma) interferon family.

7955:cd247l
gene id: 7955:cd247l
uniprot id: A6Y958
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:brinp3b
gene id: 7955:brinp3b
uniprot id: A0A8M9PJM5
names: Similarity
messages: Belongs to the BRINP family.

7955:LOC100333021
gene id: 7955:LOC100333021
uniprot id: A0A8M3AZI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

7955:LOC100001608
gene id: 7955:LOC100001608
uniprot id: A0A8M9PR86
uniprot id: A0A8M9QE12
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:fh
gene id: 7955:fh
uniprot id: Q7SX99
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homologous end-joining (NHEJ). In response to DNA damage translocates to the nucleus and accumulates at DNA double-strand breaks (DSBs): acts by catalyzing formation of fumarate (By similarity).
messages: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH.
messages: Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (By similarity). Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable).
messages: Chromosome
messages: Homotetramer.
messages: Mitochondrion
messages: Nucleus
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.
messages: cytosol

7955:zgc:162184
gene id: 7955:zgc:162184
uniprot id: A4QNV6
names: Similarity
messages: Belongs to the peptidase C2 family.

7955:fam98a
gene id: 7955:fam98a
uniprot id: X1WEE6
names: Similarity
messages: Belongs to the FAM98 family.

7955:b4galt5
gene id: 7955:b4galt5
uniprot id: Q3YL68
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (By similarity). Required for proper patterning of the dorsoventral axis during embryogenesis through the regulation of BMP signaling (PubMed:16672343). Plays a role in proteoglycan glycosylation that is required for BMP-dependent specification of the dorsoventral axis (PubMed:16672343).
messages: Expressed by the early epiboly stage and reaches a steady state level of expression by mid-somitogenesis (PubMed:16672343). Shows widespread expression throughout the embryo during the first 24 hours of development, with enhanced expression within several structures at the 20-somite stage (PubMed:16672343).
messages: Golgi apparatus
messages: Golgi stack membrane
messages: Morpholino knockdown results in dorsalized embryos which have ventrally expanded chordin expression and reduced activation of the Bmp-dependent transcription factors smad1/5/8 (PubMed:16672343). Proteoglycans exhibits defective glycosylation and a greatly reduced affinity for bmp2 (PubMed:16672343).

7955:ca4c
gene id: 7955:ca4c
uniprot id: F1QK51
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

7955:brinp3a.2
gene id: 7955:brinp3a.2
uniprot id: F1R441
names: Similarity
messages: Belongs to the BRINP family.

7955:tpd52
gene id: 7955:tpd52
uniprot id: A0A0R4IDA7
uniprot id: A0A8M2B6B7
uniprot id: A0A8M2B6F1
uniprot id: A0A8M2B6H9
uniprot id: A0A8M3AL07
uniprot id: A0A8M6YWD3
uniprot id: A3KNM2
uniprot id: I3IT45
names: Similarity
messages: Belongs to the TPD52 family.

7955:cux2a
gene id: 7955:cux2a
uniprot id: A0A8M9Q9Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

7955:rab3aa
gene id: 7955:rab3aa
uniprot id: Q6DHJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

7955:pvalb2
gene id: 7955:pvalb2
uniprot id: Q9I8V0
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity).

7955:acss1
gene id: 7955:acss1
uniprot id: F1QYS7
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

7955:LOC110438115
gene id: 7955:LOC110438115
uniprot id: A0A8M9P1L8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the reelin family.
messages: Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.
messages: Oligomer of disulfide-linked homodimers. Binds to the ectodomains of VLDLR and LRP8/APOER2.
messages: extracellular matrix

7955:edem1
gene id: 7955:edem1
uniprot id: E9QJF1
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

7955:usp20
gene id: 7955:usp20
uniprot id: A0A8M3B2G6
uniprot id: A5PN09
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme involved in beta-2 adrenergic receptor (adrb2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (adrb2). Plays a central role in adrb2 recycling and resensitization after prolonged agonist stimulation by constitutively binding adrb2, mediating deubiquitination of adrb2 and inhibiting lysosomal trafficking of adrb2. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
messages: The UBP-type zinc finger binds 3 zinc ions. However, it does not bind ubiquitin, probably because the conserved Arg in position 55 is replaced by a Glu residue (By similarity).
messages: centrosome
messages: perinuclear region

7955:mzt2b
gene id: 7955:mzt2b
uniprot id: A0A2R8PWK7
uniprot id: E9QFU9
uniprot id: F1QI17
uniprot id: Q6DC17
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MOZART2 family.
messages: Part of the gamma-tubulin complex. Interacts with TUBG1 (By similarity).
messages: centrosome
messages: spindle

7955:camta1b
gene id: 7955:camta1b
uniprot id: A0A8M6Z970
uniprot id: A0A8M9PVP1
uniprot id: A0A8M9Q7U3
uniprot id: A0A8M9QDS7
uniprot id: A0A8M9QI84
uniprot id: A0A8M9QM43
names: Similarity
names: Subunit
messages: Belongs to the CAMTA family.
messages: May interact with calmodulin.

7955:mapk8b
gene id: 7955:mapk8b
uniprot id: A0A8M6Z1Z5
uniprot id: E9QB50
uniprot id: Q9DGD9
names: Activity Regulation
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.
messages: Expressed in the nervous system during embryogenic stage 21. Expression decreases from stage 25 onwards.
messages: Nucleus
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. May play a role in the regulation of the circadian clock.
messages: Synapse
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

7955:mre11a
gene id: 7955:mre11a
uniprot id: A0A8M9QPT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRE11/RAD32 family.
messages: Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
messages: Nucleus

7955:sbds
gene id: 7955:sbds
uniprot id: Q7ZW65
names: Function
names: Similarity
messages: Belongs to the SDO1/SBDS family.
messages: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.

7955:LOC101883602
gene id: 7955:LOC101883602
uniprot id: A0A8M2BK08
uniprot id: A0A8M3AX05
uniprot id: A0A8M3AX26
uniprot id: A0A8M3BD84
names: Subcellular Location Annotation
messages: Membrane

7955:znf511
gene id: 7955:znf511
uniprot id: Q7ZZ00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

7955:caprin1a
gene id: 7955:caprin1a
uniprot id: A0A8M2BJI8
uniprot id: E7FDQ5
uniprot id: Q6DBQ6
names: Similarity
messages: Belongs to the caprin family.

7955:zgc:91890
gene id: 7955:zgc:91890
uniprot id: Q6GMG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

7955:myo1ca
gene id: 7955:myo1ca
uniprot id: A0A0H2UKD8
uniprot id: A0A8M2BCM9
uniprot id: A5PF48
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Interacts (via its IQ motifs) with calm.
messages: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).
messages: Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).
messages: cell cortex
messages: ruffle membrane
messages: stereocilium membrane

7955:nme7
gene id: 7955:nme7
uniprot id: Q9PTF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: cilium axoneme

7955:ugt1a1
gene id: 7955:ugt1a1
uniprot id: F1QAF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7955:htr1e
gene id: 7955:htr1e
uniprot id: A0A8M9P2V8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:nol8
gene id: 7955:nol8
uniprot id: A0A8M2BLC0
uniprot id: Q1LV47
names: Subcellular Location Annotation
messages: nucleolus

7955:aldh1a2
gene id: 7955:aldh1a2
uniprot id: Q90XS8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

7955:serp2
gene id: 7955:serp2
uniprot id: B0V1G1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane

7955:fam168a
gene id: 7955:fam168a
uniprot id: A0A0H2UKU6
uniprot id: A0A0H2UKW4
uniprot id: A0A8M2BKV3
uniprot id: A0A8M2BKV9
names: Similarity
messages: Belongs to the FAM168 family.

7955:si:ch211-71n6.4
gene id: 7955:si:ch211-71n6.4
uniprot id: A0A0R4IYT8
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

7955:parga
gene id: 7955:parga
uniprot id: E7F2B6
names: Similarity
messages: Belongs to the poly(ADP-ribose) glycohydrolase family.

7955:rhoab
gene id: 7955:rhoab
uniprot id: Q6DHM9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: (Microbial infection) Glycosylated at Tyr-34 by Yersinia ruckeri toxin Afp18. Mono-O-GlcNAcylation by Afp18 inhibits RhoA activation by guanine nucleotide exchange factors and blocks RhoA signaling.
messages: Belongs to the small GTPase superfamily. Rho family.
messages: Cell membrane
messages: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.

7955:hoxb5b
gene id: 7955:hoxb5b
uniprot id: A0A0R4I9D0
uniprot id: P09013
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: At the 10-somite stage, barely detectable in the paraxial mesoderm. At the 20-somite stage, expressed within the developing CNS with an anterior expression limit at somite 1.
messages: Belongs to the Antp homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

7955:afg3l2
gene id: 7955:afg3l2
uniprot id: A9JRG9
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

7955:cyb561
gene id: 7955:cyb561
uniprot id: B3DFV4
uniprot id: F6PCI4
names: Subcellular Location Annotation
messages: Membrane

7955:grem1a
gene id: 7955:grem1a
uniprot id: Q6T937
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

7955:slc25a19
gene id: 7955:slc25a19
uniprot id: A0A8M9PWT9
uniprot id: Q6TLF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7955:tefb
gene id: 7955:tefb
uniprot id: Q502I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

7955:aqp7
gene id: 7955:aqp7
uniprot id: A0A8M2B7X7
uniprot id: A0A8M9P367
uniprot id: D3TZW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

7955:gipc1
gene id: 7955:gipc1
uniprot id: Q6B337
names: Similarity
messages: Belongs to the GIPC family.

7955:tor1l2
gene id: 7955:tor1l2
uniprot id: A0A8M3AYR5
uniprot id: E7FDJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

7955:ftsj1
gene id: 7955:ftsj1
uniprot id: A8E5E3
uniprot id: F1QDU3
uniprot id: Q5U3P4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.
messages: Cytoplasm
messages: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.

7955:arhgef6
gene id: 7955:arhgef6
uniprot id: A0A8M2BKJ3
uniprot id: E7F836
names: Subcellular Location Annotation
messages: lamellipodium

7955:gtf2ird1
gene id: 7955:gtf2ird1
uniprot id: A0A8M1RNF2
uniprot id: A0A8M9PLI6
uniprot id: A0A8M9QEX5
names: Subcellular Location Annotation
messages: Nucleus

7955:stag1a
gene id: 7955:stag1a
uniprot id: F1QNA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

7955:egr1
gene id: 7955:egr1
uniprot id: B3DKJ7
uniprot id: P26632
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3' via its C2H2-type zinc fingers. The first, most N-terminal zinc finger binds to the 3'-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5'-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine. Does not bind target DNA where the cytosines have been oxidized to 5-formylcytosine or 5-carboxylcytosine.
messages: Cytoplasm
messages: Detected in muscle and brain.
messages: Nucleus
messages: Transcriptional regulator (PubMed:7945937). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the expression of proteins that are involved in inflammatory processes (By similarity). Plays a role in regulating the expression of circadian clock genes (By similarity).
messages: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death.

7955:v2rh14
gene id: 7955:v2rh14
uniprot id: A0A8M3B302
uniprot id: Q1LV87
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:LOC101883444
gene id: 7955:LOC101883444
uniprot id: A0A8M9P0U9
names: Subcellular Location Annotation
messages: Membrane

7955:ptgs2a
gene id: 7955:ptgs2a
uniprot id: Q8JH43
names: Caution
names: Similarity
messages: Belongs to the prostaglandin G/H synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:cspg4
gene id: 7955:cspg4
uniprot id: E7FCN9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:or115-11
gene id: 7955:or115-11
uniprot id: Q2PRI3
names: Subcellular Location Annotation
messages: Membrane

7955:sesn3
gene id: 7955:sesn3
uniprot id: F1R1P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

7955:si:ch211-264e16.1
gene id: 7955:si:ch211-264e16.1
uniprot id: A0A8M9P1A8
uniprot id: A0A8M9PAC8
names: Subcellular Location Annotation
messages: Membrane

7955:acss2
gene id: 7955:acss2
uniprot id: A0A2R8Q6G5
uniprot id: F1QAA7
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

7955:gtf2a1
gene id: 7955:gtf2a1
uniprot id: Q7ZUK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

7955:rpl36a
gene id: 7955:rpl36a
uniprot id: P61485
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

7955:si:dkey-33c3.1
gene id: 7955:si:dkey-33c3.1
uniprot id: X1WBF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.
messages: Membrane

7955:scgn
gene id: 7955:scgn
uniprot id: Q5XJX1
names: Subcellular Location Annotation
messages: Cytoplasm

7955:pkib
gene id: 7955:pkib
uniprot id: Q5SPN9
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

7955:ebf1a
gene id: 7955:ebf1a
uniprot id: A0A0R4IWI1
uniprot id: A0A8M3AGT4
uniprot id: A0A8M3B0H5
uniprot id: A0A8M6Z2R8
uniprot id: A0A8M6Z496
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the COE family.
messages: Detected in B cells.
messages: Forms either a homodimer or a heterodimer with a related family member.
messages: Nucleus
messages: Transcriptional activator.
messages: Up-regulated in B cells in response to runx1.

7955:hccsa.2
gene id: 7955:hccsa.2
uniprot id: A0A8M6YUX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

7955:ypel3
gene id: 7955:ypel3
uniprot id: Q6NWI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the yippee family.
messages: May be involved in proliferation and apoptosis in myeloid precursor cells.
messages: nucleolus

7955:anxa3a
gene id: 7955:anxa3a
uniprot id: Q66ID8
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

7955:trmt1
gene id: 7955:trmt1
uniprot id: A0A8M3B710
uniprot id: F1QGD9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

7955:tmem9
gene id: 7955:tmem9
uniprot id: B0S6L8
uniprot id: Q7ZW08
names: Similarity
messages: Belongs to the TMEM9 family.

7955:g6pca.1
gene id: 7955:g6pca.1
uniprot id: A0A8M1N1J9
uniprot id: E7F5Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

7955:LOC103909001
gene id: 7955:LOC103909001
uniprot id: A0A8M9P0U5
names: Similarity
names: Subunit
messages: Belongs to the EMC7 family.
messages: Component of the ER membrane protein complex (EMC).

7955:ndufb5
gene id: 7955:ndufb5
uniprot id: A8E5B7
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB5 subunit family.
messages: Complex I is composed of 45 different subunits.

7955:hs3st4
gene id: 7955:hs3st4
uniprot id: F1QME4
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

7955:sacm1lb
gene id: 7955:sacm1lb
uniprot id: A1L244
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2).

7955:LOC110437776
gene id: 7955:LOC110437776
uniprot id: A0A8M3B823
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:pdk2a
gene id: 7955:pdk2a
uniprot id: E7FD62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

7955:nfil3-2
gene id: 7955:nfil3-2
uniprot id: A0A8M2BBT7
uniprot id: E2E3F6
names: Similarity
messages: Belongs to the bZIP family. NFIL3 subfamily.

7955:si:dkey-114g7.4
gene id: 7955:si:dkey-114g7.4
uniprot id: Q1L8N6
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

7955:hnrnpabb
gene id: 7955:hnrnpabb
uniprot id: Q6NYA1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7955:dlg5b.1
gene id: 7955:dlg5b.1
uniprot id: A0A8M3BEE2
uniprot id: A0A8M9QF19
uniprot id: A0A8M9QJE1
uniprot id: A0A8M9QN58
names: Similarity
messages: Belongs to the MAGUK family.

7955:stk33
gene id: 7955:stk33
uniprot id: A0A8M3B118
uniprot id: Q5RHZ0
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:ythdf2
gene id: 7955:ythdf2
uniprot id: E7F1H9
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YTHDF family. YTHDF2 subfamily.
messages: Homozygous mutants from the first generation do not show any visible phenotype. Crossing homozygotes mutants together leads to lethality in around 70% of their progeny, because embryos do not developed past the one-cell stage. This lethality is probably mediated by defective sperm males. Defects are due to impaired decay of N6-methyladenosine (m6A)-modified maternal mRNAs, leading to impede zygotic genome activation. Embryos fail to initiate timely maternal-to-zygotic, undergo cell-cycle pause and remain developmentally delayed.
messages: Nucleus
messages: P-body
messages: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability (PubMed:28192787). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (By similarity). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs (By similarity). The YTHDF paralogs (ythdf1, ythdf2 and ythdf3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (By similarity). Plays a key role in maternal-to-zygotic transition during early embryonic development, the process during which maternally inherited mRNAs are degraded: acts by binding m6A-containing maternal mRNAs and promoting their degradation (PubMed:28192787). More than one-third of maternal mRNAs can be modified by m6A (PubMed:28192787). Binding to m6A-containing mRNAs results in mRNA degradation (By similarity). Also involved in hematopoietic stem cells specification by binding to m6A-containing mRNAs, such as notch1a, and promote their degradation (PubMed:28869969). The decreased Notch signaling following notch1a degradation promotes endothelial to hematopoietic transition (PubMed:28869969). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (By similarity). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (By similarity).
messages: Stress granule
messages: The disordered regions have the ability to interact with each other and to 'phase separate' into liquid droplets within the cytosol following binding to mRNAs containing multiple m6A-modified residues. This leads to the partition of m6A-containing mRNAs into membraneless compartments, where mRNAs may be stored, degraded or used to transport mRNAs to dendritic arbors in neurons.
messages: Ubiquitously expressed throughout early embryogenesis.
messages: cytosol

7955:tmod2
gene id: 7955:tmod2
uniprot id: Q66I39
names: Subcellular Location Annotation
messages: cytoskeleton

7955:or125-8
gene id: 7955:or125-8
uniprot id: Q2PR99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:comp
gene id: 7955:comp
uniprot id: A0A0G2KDJ5
uniprot id: A0A8M6Z914
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:clp1
gene id: 7955:clp1
uniprot id: E7F3I6
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of the tRNA splicing endonuclease complex. Component of pre-mRNA cleavage complex II (CF-II) (By similarity).
messages: Lethality before 5 days post-fertilization (dpf). Mutants display abnormal swimming behavior, abnormal head shape and curved tail. Defects are due to neuromotor defects and cerebellar neurodegeneration.
messages: Nucleus
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Its role in tRNA splicing and maturation is required for cerebellar development. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by dicer1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.
messages: Strong neural expression.

7955:si:ch73-170d6.4
gene id: 7955:si:ch73-170d6.4
uniprot id: H9GXF5
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

7955:hmces
gene id: 7955:hmces
uniprot id: A5PLB0
names: Function
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.
messages: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction.

7955:blm
gene id: 7955:blm
uniprot id: A0A8M6YUA3
uniprot id: A0A8M6YW51
uniprot id: E7EZY7
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

7955:LOC103909498
gene id: 7955:LOC103909498
uniprot id: A0A8M9QIH7
names: Similarity
messages: Belongs to the gamma-glutamyltransferase family.

7955:ambra1a
gene id: 7955:ambra1a
uniprot id: E7FAG6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat AMBRA1 family.
messages: Component of the DCX(AMBRA1) E3 ubiquitin ligase complex.
messages: Endoplasmic reticulum
messages: Expressed both maternally and zygotically. Present as maternal transcripts in the eggs and display a gradual decline until 8 hours post-fertilization (hpf), being replaced by zygotic mRNAs from 12 hpf onwards (PubMed:23348054). After 24 hpf, the transcripts are mainly localized in the brain and otic vesicles (PubMed:23348054).
messages: Mitochondrion
messages: Morpholino knockdown of ambra1a causes impaired dorso-ventral patterning in embryos (PubMed:23348054). Morpholino knockdown of ambra1a and ambra1b results in reduced autophagy and increased apoptosis during embryogenesis (PubMed:23348054). Morpholino knockdown of ambra1a and ambra1b results in impaired locomotion, caused by abnormal myogenesis (PubMed:24922546).
messages: Nucleus
messages: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex involved in cell cycle control and autophagy (PubMed:23348054). The DCX(AMBRA1) complex specifically mediates the polyubiquitination of target proteins (By similarity). Acts as an upstream master regulator of the transition from G1 to S cell phase: ambra1a specifically recognizes and binds phosphorylated cyclin-D (ccnd1, ccnd2 and ccnd3), leading to cyclin-D ubiquitination by the DCX(AMBRA1) complex and subsequent degradation (By similarity). Acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (eloc) component of CRL5 complexes (By similarity). Acts as a key regulator of autophagy by modulating the BECN1-PIK3C3 complex: controls protein turnover during neuronal development, and regulates normal cell survival and proliferation (By similarity). In normal conditions, ambra1a is tethered to the cytoskeleton via interaction with dyneins light chains (By similarity). Upon autophagy induction, ambra1a is released from the cytoskeletal docking site to induce autophagosome nucleation by mediating ubiquitination of proteins involved in autophagy (By similarity). Also acts as an activator of mitophagy (By similarity). Required for skeletal muscle development (PubMed:24922546).
messages: autophagosome
messages: cytoskeleton
messages: cytosol
messages: focal adhesion

7955:tp53rk
gene id: 7955:tp53rk
uniprot id: F1QB90
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

7955:marveld2b
gene id: 7955:marveld2b
uniprot id: A0A8M9Q3L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

7955:LOC100537363
gene id: 7955:LOC100537363
uniprot id: A0A8M3B3S0
uniprot id: E7FEC8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:mtfp1
gene id: 7955:mtfp1
uniprot id: Q6PCS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFP1 family.
messages: Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function leads to apoptosis (By similarity).
messages: Mitochondrion inner membrane

7955:LOC110438198
gene id: 7955:LOC110438198
uniprot id: A0A8M9PQ45
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

7955:galnt17
gene id: 7955:galnt17
uniprot id: E7EZL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

7955:si:ch211-106h11.1
gene id: 7955:si:ch211-106h11.1
uniprot id: A0A8M9PTX1
uniprot id: A0A8M9Q123
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

7955:fbp1b
gene id: 7955:fbp1b
uniprot id: Q7T337
names: Similarity
messages: Belongs to the FBPase class 1 family.

7955:afmid
gene id: 7955:afmid
uniprot id: A0A0R4IZ99
uniprot id: B2GQ61
uniprot id: Q566U4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynurenine formamidase family.
messages: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.
messages: Homodimer.
messages: Nucleus
messages: The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
messages: cytosol

7955:LOC100536860
gene id: 7955:LOC100536860
uniprot id: A0A286Y9R5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPC subfamily.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

7955:unm hu7910
gene id: 7955:unm_hu7910
uniprot id: A0A2R8QJF6
uniprot id: A0A8M3B1J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.
messages: Membrane

7955:pigv
gene id: 7955:pigv
uniprot id: A0A0R4ITR4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

7955:dmap1
gene id: 7955:dmap1
uniprot id: Q7ZUN3
names: Subcellular Location Annotation
messages: Nucleus

7955:mutyh
gene id: 7955:mutyh
uniprot id: B8JJK1
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs.
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

7955:tll1
gene id: 7955:tll1
uniprot id: B3DJN6
uniprot id: O57460
names: Caution
names: Cofactor
names: Function
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: During gastrulation, accumulates around the closing blastopore with greater expression ventrally. At the animal pole, expressed in the ectoderm flanking the anterior neural plate. At the 10-somite stage, expressed in the developing tailbud and cranial neural crest. At the 20-somite stage, also expressed in the hematopoietic system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for patterning ventral tissues of the tail. May increase bone morphogenetic protein (BMP) activity at the end of gastrulation by proteolytic cleavage of chordin and release of BMP from inactive complexes.

7955:phactr4b
gene id: 7955:phactr4b
uniprot id: A0A8M2B4R2
uniprot id: A0A8M2B574
uniprot id: A0A8M2B587
uniprot id: A0A8M3AI89
uniprot id: A0A8M3B1T3
uniprot id: Q6PEI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: Binds ppp1ca and actin.
messages: Cytoplasm
messages: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway (By similarity).
messages: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway.
messages: lamellipodium

7955:mpp2a
gene id: 7955:mpp2a
uniprot id: A0A8M9PW92
names: Similarity
messages: Belongs to the MAGUK family.

7955:si:ch211-168b3.1
gene id: 7955:si:ch211-168b3.1
uniprot id: A0A8M3AVV3
uniprot id: B8JLA1
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

7955:prdm1b
gene id: 7955:prdm1b
uniprot id: A0A8M3AL91
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:dmrta2
gene id: 7955:dmrta2
uniprot id: B8JLF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: May be involved in sexual development.
messages: Nucleus

7955:mrpl32
gene id: 7955:mrpl32
uniprot id: F1R044
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL32 family.
messages: Cytoplasm

7955:im:7138535
gene id: 7955:im:7138535
uniprot id: A0A8M3B005
uniprot id: F1QHG6
names: Similarity
messages: Belongs to the FAM98 family.

7955:si:dkey-42p8.3
gene id: 7955:si:dkey-42p8.3
uniprot id: A0A8M2BHV2
uniprot id: A0A8N7TB78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

7955:srsf1b
gene id: 7955:srsf1b
uniprot id: Q6NYA0
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Cytoplasm
messages: Intron retention.
messages: May play a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing.
messages: Nucleus speckle

7955:LOC108179079
gene id: 7955:LOC108179079
uniprot id: A0A8M6YW20
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:tmem205
gene id: 7955:tmem205
uniprot id: A1L2F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM205 family.
messages: Membrane

7955:LOC100007121
gene id: 7955:LOC100007121
uniprot id: A0A8M3AS10
uniprot id: A0A8M6YTQ1
uniprot id: A0A8M9PPM0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:cpt1aa
gene id: 7955:cpt1aa
uniprot id: A0A8M1N9G1
uniprot id: Q1MTA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

7955:ccnb3
gene id: 7955:ccnb3
uniprot id: Q08C91
names: Function
names: Similarity
messages: Belongs to the cyclin family.
messages: Essential for the control of the cell cycle at the G2/M (mitosis) transition.

7955:xpo1a
gene id: 7955:xpo1a
uniprot id: E7F0E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

7955:pgm1
gene id: 7955:pgm1
uniprot id: Q7SXW7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

7955:nkx2.4b
gene id: 7955:nkx2.4b
uniprot id: Q9I8L7
names: Subcellular Location Annotation
messages: Nucleus

7955:tmem161a
gene id: 7955:tmem161a
uniprot id: Q0V947
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: May play a role in protection against oxidative stress.
messages: Membrane

7955:f2r
gene id: 7955:f2r
uniprot id: A2BIP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:apela
gene id: 7955:apela
uniprot id: P0DMC2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Elabela/Toddler family.
messages: Endogenous ligand for the apelin receptor (aplnra and/or aplnrb) (PubMed:24316148, PubMed:24407481). Hormone required for mesendodermal differentiation, blood vessels formation and heart morphogenesis during early development and for adult cardiovascular homeostasis (PubMed:24316148, PubMed:24407481, PubMed:26017639, PubMed:29117894). Acts as a motogen by promoting mesendodermal cell migration during gastrulation by binding and activating the apelin receptor (PubMed:24316148, PubMed:24407481, PubMed:29117894). Acts as an early embryonic regulator of cellular movement with a role in migration and development of cardiac progenitor cells (PubMed:24316148, PubMed:24407481). May act as a chemoattractant for the activation of angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (PubMed:26017639). Positively regulates sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel sprouting. Involved in cardioprotective functions during heart failure. Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity).
messages: Expressed from the mid-blastula transition (MBT) to 3 days post-fertilization (dpf) (PubMed:24316148). Ubiquitously expressed in dividing cells of the blastoderm before becoming restricted after gastrulation to axial structures, with most prominent expression in the neural tube (PubMed:24316148).
messages: Expressed ubiquitously during late blastula and gastrula stages and becomes restricted to the lateral mesoderm, endoderm, and anterior and posterior notochord after gastrulation (PubMed:24407481).
messages: Interacts with aplnra and aplnrb (PubMed:24316148).
messages: Secreted
messages: Was named Toddler based on the phenotype.
messages: Zinc-finger-nuclease (ZFN)- or TALEN-mediated apela gene inactivation induces embryonic lethality due to heart dysgenesis around 6 days post-fertilization (dpf) (PubMed:24316148, PubMed:24407481). Mutant embryos show cardiac dysplasia ranging from a rudimentary heart to no heart (PubMed:24316148, PubMed:24407481). Embryos have minimal blood circulation, with an excess of erythrocytes accumulating at the intermediate cell mass (ICM) (PubMed:24316148, PubMed:24407481). Larvae display variable posterior truncations and, at times, tailbud duplications (PubMed:24316148). Posterior tissue defects range from loss of the ventral fin to complete tail and trunk truncations (PubMed:24316148). Embryos also display malformed pharyngeal endoderm, abnormal left-right positioning and formation of the liver (PubMed:24407481). By mid-gastrulation, embryos show reduced endodermal cell numbers and endodermal and mesodermal progenitor cell migration toward the animal pole (PubMed:24316148, PubMed:24407481). CRISPR-induced apela null mutations show also reduced endodermal cell numbers, increased rates of endodermal cells death and reduced endodermal and mesodermal cell migration at mid-gastrulation (PubMed:29117894). Show a strong decrease in the angioblast migration to the embryonic midline during late gastrulation (PubMed:26017639).
messages: extracellular space

7955:sult1st1
gene id: 7955:sult1st1
uniprot id: Q6PH37
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sulfotransferase 1 family.
messages: Cytoplasm
messages: Expressed in liver.
messages: Inhibited by Co(2+), Zn(2+), Cd(2+) and Pb(2+) ions. Inactivated by Hg(2+) and Cu(2+) ions.
messages: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a variety of xenobiotic and endogenous compounds, including 2-naphthol, hydroxychlorobiphenyls, dopamine and T3 (triiodo-L-thyronine).

7955:atxn10
gene id: 7955:atxn10
uniprot id: B3DJT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ataxin-10 family.
messages: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.
messages: perinuclear region

7955:adrb1
gene id: 7955:adrb1
uniprot id: B3DHM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:fgf11a
gene id: 7955:fgf11a
uniprot id: A0A8M9QGZ2
uniprot id: Q5TKR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Secreted

7955:dip2ca
gene id: 7955:dip2ca
uniprot id: A0A8M2B9T7
uniprot id: A0A8M2B9W7
uniprot id: A0A8M3ANN8
uniprot id: A0A8M3APB7
uniprot id: A0A8M3AZ81
uniprot id: A0A8M3B6R8
uniprot id: A0A8M6Z4R8
uniprot id: A0A8M9PY02
names: Similarity
messages: Belongs to the DIP2 family.

7955:ctsd
gene id: 7955:ctsd
uniprot id: Q8AWD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Lysosome

7955:slc19a2
gene id: 7955:slc19a2
uniprot id: E7F340
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Membrane

7955:march4
gene id: 7955:march4
uniprot id: Q5RFW5
names: Subcellular Location Annotation
messages: Membrane

7955:gpt2l
gene id: 7955:gpt2l
uniprot id: A0A8M1NQS1
uniprot id: Q6NYL5
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate.
messages: Homodimer.
messages: Incomplete sequence.

7955:mcl1b
gene id: 7955:mcl1b
uniprot id: Q568W5
names: Similarity
messages: Belongs to the Bcl-2 family.

7955:LOC557816
gene id: 7955:LOC557816
uniprot id: A0A8M9QE05
names: Similarity
messages: Belongs to the NAPRTase family.

7955:fgf13a
gene id: 7955:fgf13a
uniprot id: A0A8M9PZ61
uniprot id: E7F5G0
uniprot id: Q5TKR2
uniprot id: Q5U3Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Secreted

7955:srp14
gene id: 7955:srp14
uniprot id: Q4V9I5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP14 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm
messages: Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

7955:emsy
gene id: 7955:emsy
uniprot id: A0A8M3AWD8
uniprot id: A0A8M3AWE9
uniprot id: A0A8M3B5X7
uniprot id: A0A8M3BCQ8
uniprot id: B2GRX8
uniprot id: Q7ZUV7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer.
messages: Nucleus
messages: Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin.

7955:wee2
gene id: 7955:wee2
uniprot id: Q1LX51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Nucleus
messages: Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits cdk1 and acts as a key regulator of meiosis. Required to maintain meiotic arrest in oocytes by phosphorylating cdk1 at 'Tyr-15', leading to inhibit cdk1 activity and prevent meiotic reentry (By similarity).

7955:ntrk1
gene id: 7955:ntrk1
uniprot id: F6P1M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

7955:lrrc8ab
gene id: 7955:lrrc8ab
uniprot id: A2BF98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

7955:adora1b
gene id: 7955:adora1b
uniprot id: B0V2S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

7955:ndufa4
gene id: 7955:ndufa4
uniprot id: Q6PBH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex IV NDUFA4 subunit family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with RAB5IF (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. NDUFA4 is required for complex IV maintenance.
messages: Mitochondrion inner membrane

7955:snrpc
gene id: 7955:snrpc
uniprot id: B2GSI1
uniprot id: Q8JGS0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins snrpb, snrpd1, snrpd2, snrpd3, snrpe, snrpf and snrpg that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins snrnp70/U1-70K, snrpa/U1-A and snrpc/U1-C. snrpc/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus
messages: Still contains stable, but U1-C-deficient U1 snRNPs. Changes the alternative splicing patterns of a large set of specific target genes. Results in an early embryonic lethality at about 5 days post-fertilization.
messages: U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

7955:arhgef7b
gene id: 7955:arhgef7b
uniprot id: A0A8M6Z512
uniprot id: A0A8M6Z5N5
uniprot id: A0A8M9Q952
uniprot id: F1QA07
uniprot id: Q5PRA8
names: Subcellular Location Annotation
messages: lamellipodium

7955:mical2b
gene id: 7955:mical2b
uniprot id: A0A8M9P6G8
uniprot id: A0A8M9PGW2
uniprot id: A0A8M9PMS9
uniprot id: A0A8M9PMT4
uniprot id: A0A8M9PV03
uniprot id: A0A8M9PYF5
uniprot id: A0A8M9PYG2
uniprot id: F1RA39
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mical family.
messages: Cytoplasm
messages: Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the srf signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (By similarity). Acts as a key regulator of the srf signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase mkl1/mrtf-a presence in the nucleus and promote srf:mkl1/mrtf-a-dependent gene transcription (PubMed:24440334).
messages: Nucleus
messages: Small hearts that fail to undergo normal looping at 24 hours post-fertilization (hpf) with thin, linear morphology compared to wild-type hearts at 48 hpf. moreover, cardiomyocytes hearts are spatially disorganized. Defects in srf:mkl1/mrtf-a-dependent gene transcription.

7955:ednrba
gene id: 7955:ednrba
uniprot id: Q9DGM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:arnt2
gene id: 7955:arnt2
uniprot id: Q9DG12
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer with the aryl hydrocarbon receptor (AHR), SIM1 or HIF2A/EPAS-1.
messages: Isoform 1 and isoform 2 are most highly expressed in the brain, eye and skeletal muscle and to a lower degree in liver, heart, kidney and swim bladder. Isoform 3 is most highly expressed in the eye, forebrain, midbrain, hindbrain, skeletal muscle, gills and brain but is barely detectable in liver, heart, kidney and swim bladder. Before the pharyngula period isoform 3 is expressed throughout the entire embryo and during this period extensively in the brain and eye.
messages: Nucleus
messages: Transcription factor that plays a role in the development of the hypothalamo-pituitary axis. Specifically recognizes the xenobiotic response element (XRE) (By similarity). Isoform 1 acts as a transcriptional activator (PubMed:11072074). Isoform 3 acts as a transcriptional repressor (PubMed:10960127, PubMed:11072074).

7955:sept9b
gene id: 7955:sept9b
uniprot id: A0A2R8Q8Y9
uniprot id: A0A2R8QHK6
uniprot id: Q58EK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cytoplasm

7955:ralyl
gene id: 7955:ralyl
uniprot id: A0A8M2BB10
uniprot id: A0A8M9PF69
uniprot id: A0A8M9PPW6
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

7955:mknk2a
gene id: 7955:mknk2a
uniprot id: A0A8M9PT26
uniprot id: Q7ZVV9
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:LOC103909158
gene id: 7955:LOC103909158
uniprot id: A0A8M3AUZ1
names: Subcellular Location Annotation
messages: Membrane

7955:tmem30ab
gene id: 7955:tmem30ab
uniprot id: Q6P0V2
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

7955:tmem201
gene id: 7955:tmem201
uniprot id: A0A8M3ANM6
uniprot id: A0A8M3B645
uniprot id: A4IG66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM201 family.
messages: May be involved in actin-dependent nuclear movement. May be involved in the organization of the nuclear envelope. May recruit Ran GTPase to the nuclear periphery.
messages: Membrane
messages: Nucleus inner membrane

7955:acer2
gene id: 7955:acer2
uniprot id: E7FCF4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:hdac7a
gene id: 7955:hdac7a
uniprot id: A0A8M9PX70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

7955:man2b2
gene id: 7955:man2b2
uniprot id: A0A8M1PZ41
uniprot id: A0A8M6Z1P3
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

7955:galnt8a.1
gene id: 7955:galnt8a.1
uniprot id: A0A8M9PHA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

7955:rdh20
gene id: 7955:rdh20
uniprot id: A0A8N7UVK4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:h3f3b.1
gene id: 7955:h3f3b.1
uniprot id: B2GSF5
uniprot id: Q6PI20
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Monoubiquitinated by rag1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin. Phosphorylation on Ser-32 (H3S31ph) is specific to regions bordering centromeres in metaphase chromosomes.
messages: Serine ADP-ribosylation constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Specific interaction of trimethylated form at 'Lys-36' (H3.3K36me3) with zmynd11 is mediated by the encapsulation of Ser-32 residue with a composite pocket formed by the tandem bromo-PWWP domains.
messages: Specifically enriched in modifications associated with active chromatin such as methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with zmynd11; when trimethylated at 'Lys-36' (H3.3K36me3).
messages: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

7955:cd9a
gene id: 7955:cd9a
uniprot id: E9QBC5
uniprot id: Q6NWG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Membrane
messages: extracellular exosome

7955:gcnt4a
gene id: 7955:gcnt4a
uniprot id: A0A2R8QQE1
uniprot id: Q71SG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 14 family.
messages: Glycosyltransferase that mediates core 2 O-glycan branching, an important step in mucin-type biosynthesis.
messages: Golgi apparatus membrane
messages: Membrane

7955:LOC110438156
gene id: 7955:LOC110438156
uniprot id: A0A8M9PP91
names: Similarity
messages: Belongs to the HARBI1 family.

7955:adgrf6
gene id: 7955:adgrf6
uniprot id: A0A8M6YWS0
uniprot id: A0A8M6Z3E2
uniprot id: A0A8M9P2Z8
uniprot id: A0A8M9PC99
uniprot id: A0A8M9PHW5
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:LOC100535040
gene id: 7955:LOC100535040
uniprot id: A0A8M9Q1U4
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:ikbke
gene id: 7955:ikbke
uniprot id: F1QBC9
uniprot id: Q6DGE5
names: Subcellular Location Annotation
messages: Cytoplasm

7955:zfyve16
gene id: 7955:zfyve16
uniprot id: A0A8M1QLB2
uniprot id: E7F6D8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane

7955:bnip3
gene id: 7955:bnip3
uniprot id: A0A8M2BKA1
uniprot id: Q5VK50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

7955:zgc:122993
gene id: 7955:zgc:122993
uniprot id: A0A8M9QAR5
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:klhl15
gene id: 7955:klhl15
uniprot id: A0A2R8QC44
uniprot id: A0A8M3ANH9
uniprot id: F1R4M4
uniprot id: Q6DEL7
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Substrate-specific adapter for an E3 ubiquitin-protein ligase complex.

7955:zgc:136870
gene id: 7955:zgc:136870
uniprot id: Q29RA9
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:bfsp1
gene id: 7955:bfsp1
uniprot id: A0A8N7UVS8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: cell cortex
messages: cytoskeleton

7955:nppa
gene id: 7955:nppa
uniprot id: F1QVW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

7955:adam9
gene id: 7955:adam9
uniprot id: Q66IC3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:ocstamp
gene id: 7955:ocstamp
uniprot id: Q58EH6
names: Subcellular Location Annotation
messages: Membrane

7955:dgkh
gene id: 7955:dgkh
uniprot id: A0A8M2BFF5
uniprot id: A0A8M3AVY2
uniprot id: A0A8M3B2L0
uniprot id: A0A8M9PSN5
uniprot id: A0A8M9QFV5
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

7955:myo5b
gene id: 7955:myo5b
uniprot id: A0A8M3ALG0
uniprot id: A0A8M9P3E4
uniprot id: A0A8M9PCR9
uniprot id: A0A8M9PIE0
uniprot id: A0A8M9PQJ8
uniprot id: F1QKS0
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:casp3a
gene id: 7955:casp3a
uniprot id: Q98UI8
names: Similarity
messages: Belongs to the peptidase C14A family.

7955:zgc:153993
gene id: 7955:zgc:153993
uniprot id: Q08BX9
names: Similarity
messages: Belongs to the Bcl-2 family.

7955:atp5g1
gene id: 7955:atp5g1
uniprot id: Q6IQN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

7955:thop1
gene id: 7955:thop1
uniprot id: E7EZ90
uniprot id: Q6DHR6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

7955:adrb3a
gene id: 7955:adrb3a
uniprot id: B0UYT9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:med23
gene id: 7955:med23
uniprot id: A0A8M2B755
uniprot id: A0A8M2B7H3
uniprot id: A0A8M9PSM3
uniprot id: Q5RIW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 23 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

7955:map7a
gene id: 7955:map7a
uniprot id: A0A8M3AIT0
uniprot id: A0A8M3B292
uniprot id: E7F930
names: Similarity
messages: Belongs to the MAP7 family.

7955:ddi2
gene id: 7955:ddi2
uniprot id: A0A8M2BDE5
uniprot id: A0A8M9Q601
uniprot id: Q6TH22
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although this protein contains the conserved Asp-262 that functions as an active site, this protein does not have proteolytic activity, and may therefore be catalytically inactive.
messages: Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane. Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1. Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2. Required for cellular survival following replication stress.
messages: Belongs to the DDI1 family.
messages: Chromosome
messages: Homodimer.
messages: cytosol

7955:aadacl4
gene id: 7955:aadacl4
uniprot id: A0A8M1NVX1
uniprot id: Q08B87
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

7955:zgc:153426
gene id: 7955:zgc:153426
uniprot id: Q08C80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

7955:ryr1b
gene id: 7955:ryr1b
uniprot id: A0A8M6YTI2
uniprot id: A0A8M6YTI9
uniprot id: A0A8M6YU63
uniprot id: A0A8M6YVZ9
uniprot id: A0A8M6Z1Y4
uniprot id: A0A8M6Z1Y9
uniprot id: A0A8M6Z2L8
uniprot id: A0A8M9PA63
uniprot id: A0A8M9PFJ3
uniprot id: A0A8M9PM90
uniprot id: A0A8M9PQC8
uniprot id: A6P4B8
names: Subcellular Location Annotation
messages: Membrane
messages: Sarcoplasmic reticulum membrane

7955:slc15a1a
gene id: 7955:slc15a1a
uniprot id: A0A8M9QB23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

7955:tmem120b
gene id: 7955:tmem120b
uniprot id: G1K2N4
uniprot id: Q1LY80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Membrane
messages: Necessary for efficient adipogenesis. Does not show ion channel activity.
messages: Nucleus inner membrane

7955:fam212aa
gene id: 7955:fam212aa
uniprot id: A0A8M9PV19
uniprot id: F1QR98
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the INKA family.
messages: Contains 2 Inka boxes (also named iBox or inca box). The Inka boxes bind and inhibit PAK4 by binding a substrate-like manner.
messages: Cytoplasm
messages: Dramatic reduction in craniofacial cartilage formation.
messages: Expression is regulated by the transcription factor AP-2-alpha/tfap2a.
messages: Inhibitor of the serine/threonine-protein kinase pak4/pak5 (By similarity). Acts by binding pak4/pak5 in a substrate-like manner, inhibiting the protein kinase activity (By similarity). Required for the proper migration of neural crest cells during embryonic development, probably by inhibiting pak4/pak5 (PubMed:17314132).
messages: Interacts with pak4/pak5.
messages: Nucleus

7955:adss
gene id: 7955:adss
uniprot id: Q568F6
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Inhibited competitively by AMP and IMP and non-competitively by fructose 1,6-bisphosphate.
messages: Mitochondrion
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

7955:cyp3c3
gene id: 7955:cyp3c3
uniprot id: A0A8M6Z4Z2
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:xkr8.2
gene id: 7955:xkr8.2
uniprot id: I3IS75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

7955:fam49a
gene id: 7955:fam49a
uniprot id: A0A0R4IMR9
uniprot id: A0A8M2B7R9
uniprot id: Q7ZW35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYRI family.
messages: Membrane

7955:si:ch1073-44g3.1
gene id: 7955:si:ch1073-44g3.1
uniprot id: E7FH33
names: Similarity
messages: Belongs to the UPF0461 family.

7955:myh9a
gene id: 7955:myh9a
uniprot id: A0A8M1NEM1
uniprot id: A0A8M2BCY6
uniprot id: A0A8M9PLW1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:zmp:0000001138
gene id: 7955:zmp:0000001138
uniprot id: A4JYR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-2-microglobulin family.
messages: Secreted

7955:cldn17
gene id: 7955:cldn17
uniprot id: A8E4Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

7955:hnrnpd
gene id: 7955:hnrnpd
uniprot id: A0A8M9QC46
uniprot id: A4QP67
uniprot id: F1Q8A5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7955:amigo3
gene id: 7955:amigo3
uniprot id: A0A8M9PKB2
uniprot id: M9MMA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. AMIGO family.
messages: Membrane

7955:egfl7
gene id: 7955:egfl7
uniprot id: Q1RLZ3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC101882355
gene id: 7955:LOC101882355
uniprot id: A0A8M2BL86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM43 family.
messages: Membrane

7955:slc27a4
gene id: 7955:slc27a4
uniprot id: Q567D7
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

7955:tsn
gene id: 7955:tsn
uniprot id: Q4V9N1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translin family.
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

7955:plxnc1
gene id: 7955:plxnc1
uniprot id: A0A8M3ARP5
names: Caution
names: Similarity
messages: Belongs to the plexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:tvp23b
gene id: 7955:tvp23b
uniprot id: Q4VBU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

7955:erbb3a
gene id: 7955:erbb3a
uniprot id: A0A8M2BCY9
uniprot id: A0A8M2BD22
uniprot id: Q8AW81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

7955:hoxb3a
gene id: 7955:hoxb3a
uniprot id: A0A8M9P483
uniprot id: O42368
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: First expressed at the 1- to 2-somite stages posterior to rhombomere 5 (r5) of the developing hindbrain. By the 3- to 4-somite stages, the anterior expression limit is at the r4/r5 boundary. At 5- to 10-somite stages, expressed at high levels in r5 and r6. From the 20- to 30-somite stages, expressed weakly in r4.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

7955:aldh1a3
gene id: 7955:aldh1a3
uniprot id: Q0H2G3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

7955:moxd1l
gene id: 7955:moxd1l
uniprot id: R4GDM3
names: Similarity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.

7955:si:ch211-215k15.4
gene id: 7955:si:ch211-215k15.4
uniprot id: A0A0R4ITS1
names: Function
names: Similarity
names: Subunit
messages: Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.
messages: Belongs to the fucolectin family.
messages: Homotrimer.

7955:si:dkey-19p15.4
gene id: 7955:si:dkey-19p15.4
uniprot id: A0A8M9QKF1
names: Similarity
messages: Belongs to the peptidase S1C family.

7955:lgmn
gene id: 7955:lgmn
uniprot id: Q6NYJ7
names: Similarity
messages: Belongs to the peptidase C13 family.

7955:gc3
gene id: 7955:gc3
uniprot id: A0A8M2BCH5
uniprot id: A5PLH7
uniprot id: F1QSL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane
messages: Photoreceptor outer segment membrane

7955:LOC101886664
gene id: 7955:LOC101886664
uniprot id: A0A8M3B7Y5
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:marco
gene id: 7955:marco
uniprot id: A0A286YAI0
uniprot id: A0A8M2BH24
uniprot id: A0A8M9QFQ5
uniprot id: F1QU19
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:p2ry2.2
gene id: 7955:p2ry2.2
uniprot id: E9QHJ4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:acsl2
gene id: 7955:acsl2
uniprot id: A0A8M1RDQ4
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.

7955:timm8a
gene id: 7955:timm8a
uniprot id: Q6DEM5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer; composed of 3 copies of TIMM8A and 3 copies of TIMM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIMM22 (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of some proteins while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins (By similarity).
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM8A from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

7955:LOC796210
gene id: 7955:LOC796210
uniprot id: A0A8M9PT83
names: Similarity
messages: Belongs to the SAPAP family.

7955:slc26a10
gene id: 7955:slc26a10
uniprot id: A0A8M1QQZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

7955:ccdc85a
gene id: 7955:ccdc85a
uniprot id: A0A8M3BEL9
uniprot id: B8A5P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

7955:smx5
gene id: 7955:smx5
uniprot id: Q5RKP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: Nucleus

7955:ska3
gene id: 7955:ska3
uniprot id: A0A8M1P1R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA3 family.
messages: kinetochore
messages: spindle

7955:scg2a
gene id: 7955:scg2a
uniprot id: A0A8M3AHQ7
uniprot id: C0HM54
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Detectable in the embryo by 10 hours post-fertilization (hpf) and expression then increases gradually until it stabilizes at 24 hpf (PubMed:29757409). Highly expressed in the forebrain, midbrain, and ventral part of the neural tube but barely expressed in the hindbrain (PubMed:29757409).
messages: Increases levels of gnrh3 in the hypothalamus and of cga and gnrhr2 in the pituitary of females and stimulates spawning.
messages: Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules (By similarity). Required for normal courting behavior and spawning (PubMed:32467166).
messages: No effect on development of central arteries (PubMed:29757409). Decreased courtship behaviors and spawning success (PubMed:32467166). Normal gross gonadal morphology in males and females but males produce fewer spermatozoa (PubMed:32467166). Reduced levels of gnrh3 in the hypothalamus and telencephalon and reduced levels of oxt and avp in the telencephalon (PubMed:32467166). Reduced levels of lhb, cga, fshb and gnrhr2 in the pituitary (PubMed:32467166). Simultaneous knockout of Scg2a and Scg2b results in greatly reduced ovulation in females (PubMed:32467166).
messages: Secreted

7955:kif19
gene id: 7955:kif19
uniprot id: A0A8M1QHH9
uniprot id: A0A8M2B2G5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:LOC110439889
gene id: 7955:LOC110439889
uniprot id: A0A8M9Q180
uniprot id: A0A8M9QBN7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:nlgn3b
gene id: 7955:nlgn3b
uniprot id: A2BHL9
uniprot id: D0EVX2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:ubxn1
gene id: 7955:ubxn1
uniprot id: Q6NXA9
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: The UBA domain specifically recognizes and binds 'Lys-6'-linked polyubiquitin chains.
messages: Ubiquitin-binding protein that specifically binds 'Lys-6'-linked polyubiquitin chains. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in ubiquitin-proteasome systems (By similarity).

7955:cnp
gene id: 7955:cnp
uniprot id: A0A8M3B0U8
names: Subcellular Location Annotation
messages: Membrane

7955:nudt2
gene id: 7955:nudt2
uniprot id: Q6DG97
names: Similarity
messages: Belongs to the Nudix hydrolase family.

7955:si:ch211-87m7.2
gene id: 7955:si:ch211-87m7.2
uniprot id: A0A8M1RM35
uniprot id: A0A8M2BJR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

7955:tlr20f
gene id: 7955:tlr20f
uniprot id: A0A8M3BCI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

7955:p2ry2.1
gene id: 7955:p2ry2.1
uniprot id: E7FEY4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:si:dkey-23a13.9
gene id: 7955:si:dkey-23a13.9
uniprot id: A0A140LH11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

7955:pofut1
gene id: 7955:pofut1
uniprot id: F1R676
names: Similarity
messages: Belongs to the glycosyltransferase 65 family.

7955:scml2
gene id: 7955:scml2
uniprot id: A0A8M3AXT2
uniprot id: A0A8M3B461
uniprot id: F1RDU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

7955:topaz1
gene id: 7955:topaz1
uniprot id: A0A0N4SUA6
names: Function
messages: Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.

7955:ugt1a5
gene id: 7955:ugt1a5
uniprot id: A0A8M1NVN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7955:ndst2b
gene id: 7955:ndst2b
uniprot id: E7F995
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

7955:appb
gene id: 7955:appb
uniprot id: Q8UUR9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:skp1
gene id: 7955:skp1
uniprot id: Q6PBY8
names: Function
names: Similarity
messages: Belongs to the SKP1 family.
messages: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.

7955:sgip1a
gene id: 7955:sgip1a
uniprot id: A0A8M3ATF2
uniprot id: A0A8M3ATF7
uniprot id: A0A8M3ATG9
uniprot id: A0A8M3B0I9
uniprot id: A0A8M3B3H7
uniprot id: A0A8M3B3I1
uniprot id: A0A8M3BAF6
uniprot id: A0A8M3BAG0
uniprot id: A0A8M6Z7G8
uniprot id: A0A8M9QB26
uniprot id: A0A8M9QG40
names: Subcellular Location Annotation
messages: clathrin-coated pit

7955:cxcr5
gene id: 7955:cxcr5
uniprot id: A0A8M9PQZ3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:top3a
gene id: 7955:top3a
uniprot id: X1WCF3
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

7955:grid1a
gene id: 7955:grid1a
uniprot id: A0A8M3AJ18
uniprot id: A0A8M9P0L3
uniprot id: X1WH07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

7955:exoc1
gene id: 7955:exoc1
uniprot id: A0A286Y9W9
uniprot id: A0A2R8PY61
uniprot id: A0A8M2B7E3
uniprot id: A0A8M9P2G2
uniprot id: A0A8M9PBK9
uniprot id: A0A8M9PH55
uniprot id: Q7T2A6
names: Similarity
messages: Belongs to the SEC3 family.

7955:bmp16
gene id: 7955:bmp16
uniprot id: D2TEB7
names: Similarity
messages: Belongs to the TGF-beta family.

7955:htr3a
gene id: 7955:htr3a
uniprot id: A0A8M3AM85
uniprot id: A0A8M9PD95
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:baiap2a
gene id: 7955:baiap2a
uniprot id: A0A8M2BAV5
uniprot id: A0A8M3AQY0
uniprot id: A0A8M3B8K0
uniprot id: A0A8M9PQ60
uniprot id: Q1RLU7
names: Function
names: Subcellular Location Annotation
messages: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: ruffle

7955:wnt10b
gene id: 7955:wnt10b
uniprot id: Q801F7
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Wnt family.
messages: First detected at around 8 hours post-fertilization (hpf) within the prospective midbrain-hindbrain boundary (MHB). By 10 hpf, expressed in two stripes that converge at the dorsal midline. During somitogenesis, this expression domain extends to the prospective epiphysis and the dorsal midline of the hindbrain; unlike wnt1, wnt10b is detected in the prospective cerebellum. The hindbrain domain bifurcates along the midline to form two dorsolateral columns with transverse bands of up-regulation at rhombomere boundaries; these are refined into stripes which are maintained at least until at least 48 hpf. At 30 hpf, expressed in the epiphysis, the dorsal midline of the optic tectum, the anterior half of the MHB constriction and in the hindbrain walls.
messages: In the embryo, expressed in the developing central nervous system (CNS), with an expression pattern very similar to that of wnt1.
messages: Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Involved in neurogenesis. Performs a partially redundant function with wnt1 in the formation of the midbrain-hindbrain boundary (MHB) organizer.
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Secreted
messages: extracellular matrix

7955:dnmt3bb.1
gene id: 7955:dnmt3bb.1
uniprot id: A0A8M2B8X0
uniprot id: A0A8M3AV60
uniprot id: A0A8M3AY81
uniprot id: Q588C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Nucleus

7955:orai1b
gene id: 7955:orai1b
uniprot id: A0A0R4I9A7
uniprot id: Q6TLE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores.
messages: Cell membrane
messages: Membrane

7955:cnrip1a
gene id: 7955:cnrip1a
uniprot id: Q6DBX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CNRIP family.
messages: Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.
messages: Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.

7955:ust
gene id: 7955:ust
uniprot id: A0A8M3AWA0
uniprot id: Q402B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:trhra
gene id: 7955:trhra
uniprot id: F1RAS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

7955:tspan5b
gene id: 7955:tspan5b
uniprot id: Q5PR95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7955:crygm2d13
gene id: 7955:crygm2d13
uniprot id: Q6DH12
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:mmp15a
gene id: 7955:mmp15a
uniprot id: E7FFQ4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

7955:ikbkb
gene id: 7955:ikbkb
uniprot id: A0A8M1NIE6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7955:syt2a
gene id: 7955:syt2a
uniprot id: A0A8M2BLD2
uniprot id: A0A8M9P5C1
uniprot id: F1R5C0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: synaptic vesicle membrane

7955:u2af2a
gene id: 7955:u2af2a
uniprot id: A0A8M9PJH8
uniprot id: E7F8Y4
uniprot id: Q4KMI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Necessary for the splicing of pre-mRNA.
messages: Nucleus

7955:LOC110438299
gene id: 7955:LOC110438299
uniprot id: A0A8M9PET3
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

7955:st3gal3b
gene id: 7955:st3gal3b
uniprot id: A0A8M2BAD2
uniprot id: A0A8M9Q7C0
uniprot id: E7FBG1
uniprot id: Q702R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

7955:dnajc22
gene id: 7955:dnajc22
uniprot id: E7F2F5
names: Function
names: Subcellular Location Annotation
messages: May function as a co-chaperone.
messages: Membrane

7955:trabd2b
gene id: 7955:trabd2b
uniprot id: A0A8M2BED6
uniprot id: E7F4V6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIKI family.
messages: Cell membrane
messages: Divalent metal cations. Mn(2+) or Co(2+).
messages: Membrane
messages: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation (By similarity).
messages: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.

7955:tmem98
gene id: 7955:tmem98
uniprot id: A1L279
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM98 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: extracellular exosome

7955:or106-3
gene id: 7955:or106-3
uniprot id: Q2PRL4
names: Subcellular Location Annotation
messages: Membrane

7955:glud1a
gene id: 7955:glud1a
uniprot id: Q6NZ29
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

7955:lgr4
gene id: 7955:lgr4
uniprot id: A0A8M9QHT5
uniprot id: E7FE13
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in the neural plate border, Kupffer's vesicle, neural tube, otic vesicles, midbrain, eyes, forebrain and brain ventricular zone by 24 hours post-fertilization (hpf). From 36 to 96 hpf, expression is detected in the midbrain-hindbrain boundary, otic vesicles, pharyngeal arches, cranial cartilages such as Meckel's cartilages, palatoquadrates, and ceratohyals, cranial cavity, pectoral fin buds, brain ventricular zone, ciliary marginal zone, and digestive organs such as the intestine, liver and pancreas.
messages: Membrane
messages: Morpholino knockdown results in disorganization of the olfactory bulbs with a significant reduction of GnRH neuronal development compared with uninjected embryos.
messages: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May play a role in regulating the circadian rhythms of plasma lipids. Required for proper development of GnRH neurons (gonadotropin-releasing hormone expressing neurons) that control the release of reproductive hormones from the pituitary gland (PubMed:32493844).

7955:nadk2
gene id: 7955:nadk2
uniprot id: A0A0R4IKV3
uniprot id: A0A8M2B840
uniprot id: A0A8M2B8E7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD kinase family.
messages: Homodimer.
messages: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.
messages: Mitochondrion

7955:soul5
gene id: 7955:soul5
uniprot id: F1QF69
names: Similarity
messages: Belongs to the HEBP family.

7955:anks1ab
gene id: 7955:anks1ab
uniprot id: A0A8M6YZ10
uniprot id: A0A8M9Q0Z5
uniprot id: A0A8M9Q7A0
uniprot id: X1WBF0
names: Subcellular Location Annotation
messages: Cytoplasm

7955:ptpn11b
gene id: 7955:ptpn11b
uniprot id: Q7SY37
uniprot id: S6CMQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

7955:gabarapl2
gene id: 7955:gabarapl2
uniprot id: Q6TH05
names: Similarity
messages: Belongs to the ATG8 family.

7955:aste1
gene id: 7955:aste1
uniprot id: Q1LYL8
names: Function
names: Similarity
messages: Belongs to the asteroid family.
messages: Possible role in EGF receptor signaling.

7955:fam8a1b
gene id: 7955:fam8a1b
uniprot id: Q56A52
names: Subcellular Location Annotation
messages: Membrane

7955:dguok
gene id: 7955:dguok
uniprot id: A0A8M9Q805
uniprot id: A5WUY2
names: Similarity
messages: Belongs to the DCK/DGK family.

7955:zgc:112408
gene id: 7955:zgc:112408
uniprot id: A0A8M3ANI9
uniprot id: Q561U1
names: Similarity
messages: Belongs to the band 7/mec-2 family.

7955:stoml2
gene id: 7955:stoml2
uniprot id: Q7SY50
names: Similarity
messages: Belongs to the band 7/mec-2 family.

7955:LOC103909640
gene id: 7955:LOC103909640
uniprot id: A0A8M9PE72
names: Subcellular Location Annotation
messages: Membrane

7955:csf3a
gene id: 7955:csf3a
uniprot id: A0A8M6Z8U5
uniprot id: B8ZHI7
names: Similarity
messages: Belongs to the IL-6 superfamily.

7955:cilp
gene id: 7955:cilp
uniprot id: A0A8M1NUZ8
names: Subcellular Location Annotation
messages: extracellular matrix

7955:epob
gene id: 7955:epob
uniprot id: A0A8M3AWM3
uniprot id: A0A8M9QCG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPO/TPO family.
messages: Secreted

7955:ogfod2
gene id: 7955:ogfod2
uniprot id: A3KGZ2
names: Cofactor
names: Similarity
messages: Belongs to the OGFOD2 family.
messages: Binds 1 Fe(2+) ion per subunit.

7955:arrdc3a
gene id: 7955:arrdc3a
uniprot id: Q1ECU3
names: Similarity
messages: Belongs to the arrestin family.

7955:alox5b.2
gene id: 7955:alox5b.2
uniprot id: Q1ECU8
uniprot id: X1WD38
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:si:dkey-246g23.4
gene id: 7955:si:dkey-246g23.4
uniprot id: A0A8M9PFG6
uniprot id: F1QHU5
names: Subcellular Location Annotation
messages: Membrane

7955:olfml2a
gene id: 7955:olfml2a
uniprot id: B0UXR7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:si:zfos-1069f5.1
gene id: 7955:si:zfos-1069f5.1
uniprot id: A0A8M9QP96
names: Subunit
messages: Forms a complex composed of PDGFRL, TNK2 and GRB2.

7955:epdl1
gene id: 7955:epdl1
uniprot id: F1RA32
names: Similarity
messages: Belongs to the ependymin family.

7955:skap1
gene id: 7955:skap1
uniprot id: A1L1P4
uniprot id: F1R4C0
names: Similarity
messages: Belongs to the SKAP family.

7955:ptprn2
gene id: 7955:ptprn2
uniprot id: A0A8M9Q7I8
uniprot id: A0A8M9QGN0
uniprot id: A3KPJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
messages: Membrane
messages: secretory vesicle membrane

7955:tmem88b
gene id: 7955:tmem88b
uniprot id: A0A0G2KG51
uniprot id: A0A8M2BJJ4
uniprot id: E7F115
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM88 family.
messages: Membrane

7955:ptx4
gene id: 7955:ptx4
uniprot id: A0A8M9Q479
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:tspan7b
gene id: 7955:tspan7b
uniprot id: B0VEQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7955:ca2
gene id: 7955:ca2
uniprot id: Q6PFU7
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

7955:mep1b
gene id: 7955:mep1b
uniprot id: B8JKC0
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:zgc:112392
gene id: 7955:zgc:112392
uniprot id: Q501Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

7955:mrps17
gene id: 7955:mrps17
uniprot id: Q503X4
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

7955:apln
gene id: 7955:apln
uniprot id: Q4TTN8
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apelin family.
messages: Endogenous ligand for the apelin receptor (aplnra and/or aplnrb) (PubMed:17336905). Drives internalization of the apelin receptor (By similarity). Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis (PubMed:17336905). Plays a role in early coronary blood vessels formation. Mediates myocardial contractility in an ERK1/2-dependent manner. May also have a role in the central control of body fluid homeostasis (By similarity).
messages: Expressed at the end of gastrulation (at protein level) (PubMed:24407481). Expressed in the embryo from 7 to 48 hours post-fertilization (hpf) (PubMed:17336905). Expressed in the axial mesoderm and its later derivative, the notochord at 11.5 hpf (PubMed:17336905). Expressed in the forming head and heart and in the posterior notochord at 18 hpf (PubMed:17336905).
messages: Morpholino knockdown of the protein show impaired gastrulation and heart formation (PubMed:17336905). Embryos display reduced migration of anterior lateral plate mesoderm (LPM) cells and cardiac progenitor cells (angioblasts) toward the midline during late gastrulation (PubMed:17336905, PubMed:26017639). Embryos show altered cardiac gene expression (PubMed:17336905). Embryos with CRISPR-induced apelin and apela null mutations show a strong decrease in the angioblast migration to the embryonic midline during late gastrulation (PubMed:26017639).
messages: Secreted
messages: extracellular space

7955:dmrt2b
gene id: 7955:dmrt2b
uniprot id: A0SDZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

7955:zgc:101100
gene id: 7955:zgc:101100
uniprot id: Q6DC54
names: Subcellular Location Annotation
messages: Nucleus

7955:aasdhppt
gene id: 7955:aasdhppt
uniprot id: Q4V8T8
names: Similarity
messages: Belongs to the P-Pant transferase superfamily. AcpS family.

7955:uncx4.1
gene id: 7955:uncx4.1
uniprot id: Q50D79
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the paired homeobox family. Unc-4 subfamily.
messages: In the somite, it is restricted to the caudal half of the newly formed somite and sclerotome.
messages: Marker of antero-posterior subdivisions of the somite.
messages: Nucleus
messages: Transcription factor involved in somitogenesis and neurogenesis.

7955:grem2a
gene id: 7955:grem2a
uniprot id: F1R4W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

7955:LOC100002481
gene id: 7955:LOC100002481
uniprot id: A0A8M3B3L4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:LOC101886370
gene id: 7955:LOC101886370
uniprot id: A0A8M9PZ08
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:cldni
gene id: 7955:cldni
uniprot id: Q90XR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

7955:uqcrc2b
gene id: 7955:uqcrc2b
uniprot id: Q6IQ59
names: Similarity
messages: Belongs to the peptidase M16 family.

7955:rab18b
gene id: 7955:rab18b
uniprot id: Q6DHC1
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Lipid droplet
messages: Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (By similarity). Plays a role in apical endocytosis/recycling (By similarity). Plays a key role in eye and brain development and neurodegeneration (PubMed:21473985).
messages: The most common abnormalities observed at 3 days post-fertilization are microphthalmia, microcephaly, pericardial edema, delayed jaw formation, a reduced overall body size, and a general developmental delay. Further characterization revealed that the rab18b morphants have delayed retinal development and abnormal retinal lamination, residual nucleated lens fiber cells, widely open choroid fissure, and microphthalmia at day 3.

7955:puf60a
gene id: 7955:puf60a
uniprot id: A0A2R8QFM1
uniprot id: A0A8M2BAQ4
uniprot id: A0A8M2BAZ4
uniprot id: A8E4R7
uniprot id: F1QZ57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM half pint family.
messages: Nucleus

7955:LOC799481
gene id: 7955:LOC799481
uniprot id: A0A8M3AV27
names: Subcellular Location Annotation
messages: Nucleus

7955:dbpa
gene id: 7955:dbpa
uniprot id: E2E3F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

7955:osbpl2b
gene id: 7955:osbpl2b
uniprot id: A0A8M2B8V1
uniprot id: Q7ZVL1
names: Similarity
messages: Belongs to the OSBP family.

7955:foxi3a
gene id: 7955:foxi3a
uniprot id: A3KNJ3
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed at the gastrula stage in the presumptive ectoderm.
messages: Expressed in ionocyte precursors.
messages: Nucleus
messages: Transcription factor required for epithelial cell differentiation (PubMed:16946087, PubMed:17555741, PubMed:17375188). Involved in specification of skin ionocytes from epidermal precursors (PubMed:16946087, PubMed:17555741, PubMed:17375188).

7955:si:dkey-33i11.4
gene id: 7955:si:dkey-33i11.4
uniprot id: C0HJJ0
uniprot id: X5IY73
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FXYD family.
messages: Cell membrane
messages: Detected in adult gill and in larval skin at 2 days post-fertilization (at protein level). In adult gill, strong expression is found in the basal regions of the secondary lamellae.
messages: Expressed from 1 day post-fertilization.
messages: Induced in larvae and adult gills by low salinity and repressed by high salinity.
messages: May modulate the activity of a sodium/potassium-transporting ATPase.
messages: Morpholino knockdown of the protein results in an increased number of sodium/potassium-transporting ATPase-expressing cells in larval skin.

7955:gys2
gene id: 7955:gys2
uniprot id: Q5RGX8
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

7955:cdh8
gene id: 7955:cdh8
uniprot id: A0A8M6Z1S0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane

7955:cenpa
gene id: 7955:cenpa
uniprot id: Q803H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H3 family.
messages: Component of centromeric nucleosomes, where DNA is wrapped around a histone octamer core. The octamer contains two molecules each of H2A, H2B, CENPA and H4 assembled in one CENPA-H4 heterotetramer and two H2A-H2B heterodimers. CENPA modulates the DNA-binding characteristics of nucleosomes so that protruding DNA ends have higher flexibility than in nucleosomes containing conventional histone H3.
messages: Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis.
messages: Nucleus
messages: centromere

7955:kcnk6
gene id: 7955:kcnk6
uniprot id: A0A8M1N7B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

7955:fth1a
gene id: 7955:fth1a
uniprot id: Q9DDT0
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

7955:efcab1
gene id: 7955:efcab1
uniprot id: Q1LWZ0
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Seems to regulate the assembly of both ODAs and their axonemal docking complex onto ciliary microtubules (By similarity). Regulates ciliary and flagellar motility and is required for cilia-driven determination of body laterality (PubMed:31240264).
messages: Component of the outer dynein arm-docking complex along with ODAD1, ODAD2, ODAD3 and ODAD4.
messages: Knockout mutants show situs invertus but normal formation of Kupffer's vesicle (KV) cilia (PubMed:31240264). However, many of the KV cilia in the mutant beat with an irregular cycle in contrast to the smooth rotary movement in wild-type fish (PubMed:31240264).
messages: Regulates ciliary motility and is required for cilia-driven determination of body laterality.
messages: cilium axoneme

7955:leo1
gene id: 7955:leo1
uniprot id: Q6NYV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LEO1 family.
messages: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). PAF1C seems to be required for multiple steps in cardiac formation. Involved in heart development and required for differentiation of the atrioventricular boundary. Required for neural crest cell development.
messages: Component of the PAF1 complex, which at least consists of cdc73, paf1, leo1, ctr9 and rtf1 (By similarity). The PAF1 complex interacts with PHF5A (By similarity). Interacts with ctr9 (PubMed:21338598).
messages: Nucleus

7955:sema3ab
gene id: 7955:sema3ab
uniprot id: Q9W686
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the semaphorin family.
messages: Expressed in rhombomeres three and five, and in the posterior half of newly formed somites which is avoided by ventrally extending motor axons.
messages: Might normally influence the midsegmental pathway choice of the ventrally extending motor axons by contributing to a repulsive domain in the posterior somite.
messages: Secreted

7955:trmt1l
gene id: 7955:trmt1l
uniprot id: A0A8N7TEL4
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: May play a role in motor coordination and exploratory behavior.

7955:slc6a1l
gene id: 7955:slc6a1l
uniprot id: A0A8M9PHW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:phb
gene id: 7955:phb
uniprot id: A0A8M2BB12
uniprot id: Q7T1D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

7955:vtg2
gene id: 7955:vtg2
uniprot id: A8WGJ1
uniprot id: Q1MTC4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:dnaja
gene id: 7955:dnaja
uniprot id: A0A8M9PNG1
names: Subcellular Location Annotation
messages: Membrane

7955:sp8b
gene id: 7955:sp8b
uniprot id: Q6P0J3
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Sp1 C2H2-type zinc-finger protein family.
messages: Detected in the forebrain, prospective midbrain/hindbrain boundary, tail bud, and neural keel and neural tube in the somitogenesis stages. Expressed in the pectoral fin bud, and the signal is restricted to the apical fold.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos.

7955:rnf13
gene id: 7955:rnf13
uniprot id: Q803J9
names: Subcellular Location Annotation
messages: Membrane

7955:bcan
gene id: 7955:bcan
uniprot id: A4JYN2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

7955:ppp2cb
gene id: 7955:ppp2cb
uniprot id: Q803G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

7955:gna14a
gene id: 7955:gna14a
uniprot id: A0A2R8RNG4
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

7955:nr1d4b
gene id: 7955:nr1d4b
uniprot id: U3M0S0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Heterodimer; with an rxr molecule. Binds DNA preferentially as a rar/rxr heterodimer.
messages: Nucleus

7955:mc3r
gene id: 7955:mc3r
uniprot id: F1QQG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

7955:clcn2a
gene id: 7955:clcn2a
uniprot id: A0A8M9QJE0
uniprot id: A0A8M9QJE6
uniprot id: F1Q5F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.
messages: Cell membrane
messages: Membrane

7955:polr2i
gene id: 7955:polr2i
uniprot id: Q1LVK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

7955:si:dkey-202l22.6
gene id: 7955:si:dkey-202l22.6
uniprot id: A0A0R4IA28
names: Subcellular Location Annotation
messages: Nucleus

7955:slc25a40
gene id: 7955:slc25a40
uniprot id: Q6DHC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane
messages: Probable mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles (By similarity). Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters (By similarity).

7955:slc44a1a
gene id: 7955:slc44a1a
uniprot id: F1Q9M4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

7955:cplx2l
gene id: 7955:cplx2l
uniprot id: Q6DHG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

7955:slc39a10
gene id: 7955:slc39a10
uniprot id: A0A0R4IJJ7
uniprot id: A0A8M3AVY6
uniprot id: Q6PEH9
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Cell membrane
messages: Membrane
messages: Morpholino knockdown of the protein causes delayed epiboly and deformities of the head, eye, heart and tail.
messages: Undergoes N-terminal ectodomain shedding.
messages: Zinc-influx transporter (PubMed:18477665). When associated with slc39a6, the heterodimer slc39a10/slc39a6 has a functional role in epithelial-mesenchymal transition (EMT) during embryonic development (PubMed:27274087). Slc39a10/slc39a6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (By similarity). When associated with slc39a6, the heterodimer controls Ncam1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity).

7955:itih5
gene id: 7955:itih5
uniprot id: A0A8M1PU27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

7955:bcl2a
gene id: 7955:bcl2a
uniprot id: Q564A4
names: Similarity
messages: Belongs to the Bcl-2 family.

7955:toe1
gene id: 7955:toe1
uniprot id: B8A5U4
names: Similarity
messages: Belongs to the CAF1 family.

7955:sema5ba
gene id: 7955:sema5ba
uniprot id: A0A8M2BFB2
uniprot id: F1QPQ6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:si:ch211-253h3.1
gene id: 7955:si:ch211-253h3.1
uniprot id: A0A8M1RSL2
uniprot id: A0A8M2BJA8
uniprot id: A0A8M2BJC9
uniprot id: A0A8M6YYK4
names: Subcellular Location Annotation
messages: Synapse
messages: axon
messages: dendritic spine

7955:aptx
gene id: 7955:aptx
uniprot id: A0A8M3ALA1
uniprot id: P61799
names: Domain
names: Function
names: Subcellular Location Annotation
messages: DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity).
messages: The C2H2-type zinc finger mediates DNA-binding.
messages: The HIT domain is required for enzymatic activity.
messages: The histidine triad, also called HIT motif, forms part of the binding loop for the alpha-phosphate of purine mononucleotide.
messages: nucleolus
messages: nucleoplasm

7955:nrxn1b
gene id: 7955:nrxn1b
uniprot id: A0A8M3AYQ8
uniprot id: A0A8M3AYS8
uniprot id: A0A8M3B4Y5
uniprot id: A0A8M3B7R4
uniprot id: A0A8M9PXV2
uniprot id: F1R7M4
uniprot id: F8W597
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:ppm1na
gene id: 7955:ppm1na
uniprot id: Q6NY18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

7955:ebf2
gene id: 7955:ebf2
uniprot id: A0A8M2BCW5
uniprot id: A2BIQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

7955:si:cabz01071907.1
gene id: 7955:si:cabz01071907.1
uniprot id: A0A8M3AQL1
uniprot id: A0A8M9QBY2
names: Similarity
messages: Belongs to the HARBI1 family.

7955:top2b
gene id: 7955:top2b
uniprot id: A0A8M2B6J3
uniprot id: Q1LUT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
messages: nucleolus
messages: nucleoplasm

7955:dsc2l
gene id: 7955:dsc2l
uniprot id: F1QSQ0
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell membrane
messages: Component of intercellular desmosome junctions (PubMed:22235774). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (PubMed:22235774). Involved in the formation and structural organization of desmosome cell-cell junctions during embryonic development (PubMed:22235774). Required for embryogenesis, specifically for progression of epiboly and normal convergence-extension movements during gastrulation (PubMed:22235774). Required for the development of desmosomal-rich midlines in the heart (PubMed:17186466). Plays an important role in ventricular contraction and resulting heart stroke volume (PubMed:17186466, PubMed:33784018).
messages: Expressed at fertilization and up to 2 hours post-fertilization (hpf), expression then declines to low levels at 4 hpf before increasing at 6 hpf onwards until 96 hpf (PubMed:22235774). Expressed in the atrium, ventricle, and both the inflow and outflow tracts at 48 hours post-fertilization (PubMed:17186466).
messages: Expressed at low levels in the brain and heart.
messages: Morpholino knockdowns show increased embryonic lethality, with embryos that die developing one of two clear phenotypes following developmental arrest at 10 hpf (PubMed:22235774). The first group show severe epiboly arrest with desmosomal cadherins and enveloping layer becoming detached from the external yolk syncytial layer that continued to undergo epiboly (PubMed:22235774). This results in a population of cells at the animal pole which maintain cell division and some gastrulation movements (PubMed:22235774). In the second phenotype the enveloping layer is attached to the yolk but does not progress through epiboly (PubMed:22235774). The enveloping layer remains attached in a ring to the base of the blastoderm until embryos arrest due to mechanical stress and detachment of the blastoderm from the yolk cell following extensive proliferation and blastoderm growth (PubMed:22235774). Embryos that survive to 14 hpf show morphological defects characteristic of altered gastrulation movements including a shorter embryonic axis, undulating notochord and somites that show either altered morphology or substantial disorganization (PubMed:22235774). Reduced abundance of desmosome cell junctions between cells at the shield stage at 6 hpf (PubMed:22235774). At the 8 somite stage (11 hpf) desmosomes are present however show poor structural organization with a wide intercellular space or unpaired plaques (PubMed:22235774). Bradycardia, chamber dilation, and abnormal cardiac contractility with progressive pericardial edema developing by 48 hpf (PubMed:17186466). Normal desmosomal midline fails to form in the myocardial tissue of the ventricle by 48 hpf (PubMed:17186466). Cardiac edema associated with blood accumulation around the yolk sac, accompanied by decreased cardiac stroke volumes and ventricular contraction at 3 days post-fertilization (PubMed:33784018).
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
messages: desmosome

7955:pgp
gene id: 7955:pgp
uniprot id: F1QGU0
names: Cofactor
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Divalent metal ions. Mg(2+) is the most effective.

7955:LOC100330151
gene id: 7955:LOC100330151
uniprot id: A0A8M3AP37
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:med29
gene id: 7955:med29
uniprot id: B0R0L4
uniprot id: Q8JHI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 29 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

7955:gsg1l
gene id: 7955:gsg1l
uniprot id: Q4V922
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As a component of the AMPAR complex, modifies AMPA receptor (AMPAR) gating.
messages: Belongs to the GSG1 family.
messages: Cell membrane
messages: Component of the AMPAR complex.
messages: Synapse

7955:or115-8
gene id: 7955:or115-8
uniprot id: Q2PRI0
names: Subcellular Location Annotation
messages: Membrane

7955:slc26a6
gene id: 7955:slc26a6
uniprot id: A9C3T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

7955:stm
gene id: 7955:stm
uniprot id: A2VD23
names: Developmental Stage
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Detected in the otic placode and the pineal gland in embryos 24 hours after fertilization. Detected in the sensory hair epithelium along the entire length of the lateral line organ in larvae 72 hours post fertilization. Restricted mainly to neuroepithelial patches in the ear of larvae 72 hours post fertilization.
messages: Essential for the formation of otoliths in the inner ear of developing larvae and for the perception of gravity and acceleration. May be one of the organic components of the ortholiths.
messages: Otoliths are structures composed of proteins and calcium carbonate that are found in the fish inner ear in contact with the otic epithelium. They are essential for the perception of gravity and acceleration.
messages: Secreted

7955:rhbdf1b
gene id: 7955:rhbdf1b
uniprot id: A0A8M9QMW9
uniprot id: E7F9C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.

7955:peli1a
gene id: 7955:peli1a
uniprot id: A0A8M2B719
uniprot id: A0A8M9Q7P1
names: Similarity
messages: Belongs to the pellino family.

7955:vipr2
gene id: 7955:vipr2
uniprot id: A7UH65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

7955:LOC100329231
gene id: 7955:LOC100329231
uniprot id: A0A8M9P017
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:nop53
gene id: 7955:nop53
uniprot id: Q32LR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP53 family.
messages: May play a role in ribosome biogenesis.
messages: nucleolus
messages: nucleoplasm

7955:slc15a1b
gene id: 7955:slc15a1b
uniprot id: Q7SYE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

7955:srgap2
gene id: 7955:srgap2
uniprot id: B0S6J3
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Nucleus
messages: Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex. Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons. Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation.
messages: Postsynaptic cell membrane
messages: Postsynaptic density
messages: The F-BAR domain mediates oligomerization, binds membranes, and induces plasma membrane protrusions.
messages: cytosol
messages: dendritic spine
messages: lamellipodium
messages: phagosome

7955:si:ch211-197g15.9
gene id: 7955:si:ch211-197g15.9
uniprot id: A0A8M1RJI1
uniprot id: A0A8M3AMC1
names: Similarity
messages: Belongs to the IFI44 family.

7955:zgc:171424
gene id: 7955:zgc:171424
uniprot id: A0A8M9QH83
uniprot id: A8WFS4
uniprot id: Q2LK86
names: Function
names: Similarity
names: Subunit
messages: Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.
messages: Belongs to the fucolectin family.
messages: Homotrimer.

7955:rfx4
gene id: 7955:rfx4
uniprot id: A2BGA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFX family.
messages: May activate transcription by interacting directly with the X-box.
messages: Nucleus

7955:LOC108191511
gene id: 7955:LOC108191511
uniprot id: A0A8M6Z8X3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:lsm14b
gene id: 7955:lsm14b
uniprot id: A8E580
uniprot id: F1Q898
names: Similarity
messages: Belongs to the LSM14 family.

7955:tpcn2
gene id: 7955:tpcn2
uniprot id: A0JMD4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily.
messages: Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position (By similarity).
messages: Homodimer (By similarity).
messages: Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate). Localizes to the lysosomal and late endosome membranes where it regulates organellar membrane excitability, membrane trafficking, and pH homeostasis.
messages: Late endosome membrane
messages: Lysosome membrane
messages: N-glycosylated.

7955:ciapin1
gene id: 7955:ciapin1
uniprot id: A0A8M2BLJ5
uniprot id: A0A8M2BLK5
uniprot id: B2GNT9
uniprot id: Q6AZB3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion intermembrane space
messages: Monomer. Interacts with NDOR1. Interacts with CHCHD4.
messages: Monomer. Interacts with ndor1. Interacts with chchd4.
messages: Nucleus
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

7955:ahsa1a
gene id: 7955:ahsa1a
uniprot id: Q29RB9
uniprot id: Q5RIK5
names: Similarity
messages: Belongs to the AHA1 family.

7955:wars2
gene id: 7955:wars2
uniprot id: Q5CZN2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

7955:si:rp71-1c23.3
gene id: 7955:si:rp71-1c23.3
uniprot id: A2BHB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (qrsl1), B (gatb) and C (gatc) subunits.

7955:nedd8l
gene id: 7955:nedd8l
uniprot id: Q6DGU4
names: Similarity
messages: Belongs to the ubiquitin family.

7955:si:dkey-188i13.10
gene id: 7955:si:dkey-188i13.10
uniprot id: A0A8M2B3Y9
uniprot id: B8A487
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

7955:prf1.6
gene id: 7955:prf1.6
uniprot id: A4QP80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

7955:ugt5d1
gene id: 7955:ugt5d1
uniprot id: D3XDB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7955:edf1
gene id: 7955:edf1
uniprot id: Q6PBY3
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Probable transcriptional coactivator.

7955:gabra1
gene id: 7955:gabra1
uniprot id: A0A8M3ALU6
uniprot id: Q08BJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:slc25a28
gene id: 7955:slc25a28
uniprot id: B8A686
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7955:arl2bp
gene id: 7955:arl2bp
uniprot id: A0A8M1PDV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL2BP family.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: Plays a role as an effector of the ADP-ribosylation factor-like protein 2, ARL2.
messages: centrosome
messages: cilium basal body

7955:dpf2
gene id: 7955:dpf2
uniprot id: Q5XJL8
names: Similarity
messages: Belongs to the requiem/DPF family.

7955:LOC108179145
gene id: 7955:LOC108179145
uniprot id: A0A8M6YW25
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC100150811
gene id: 7955:LOC100150811
uniprot id: A0A8M9QNP8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:hs6st2
gene id: 7955:hs6st2
uniprot id: Q800H9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Required for muscle development and angiogenesis.
messages: Belongs to the sulfotransferase 6 family.
messages: Expressed both maternally and zygotically throughout the cleavage, gastrulation and somitogenesis stages.
messages: Expressed ubiquitously during gastrulation. During early somitogenesis, strong expression in head and presumptive brain. During mid-somitogenesis, strong expression in eye, hindbrain and somitic boundaries and weak expression in tail bud. During late somitogenesis, strong expression in eye, hindbrain, branchial arch primordia, spinal cord and ventral medial somites. At 24 hours post-fertilization (hpf), strong expression throughout the head, with expression receeding from the trunk spinal cord, ventral medial somites and somitic boundaries; expressed in cells surrounding vascular structures of the dorsal aorta and caudal vein in the tail. At 36 hpf, expressed in lens, optic stalk, hindbrain and pectoral fin. At 48 hpf, expressed in eye, brain, otic vesicle and branchial arches.
messages: Membrane
messages: Morpholino knockdown results in defects in the branching morphogenesis of the caudal vein and defects in somite specification with impaired muscle differentiation.

7955:ccbe1
gene id: 7955:ccbe1
uniprot id: A0A8M6YWX1
uniprot id: A0A8M9P3B9
uniprot id: A8WGB1
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CCBE1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Not expressed in blood or lymphatic endothelial cells, correlating spatially and temporally with the migration routes of endothelial cells that bud from the PCV, migrate in association with somite boundaries and seed the horizontal myoseptum region from where lymphatic precursors later migrate.
messages: Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways.
messages: Restricted expression during development with expression in the pronephros and ventral mesenchyme at 24 hours post fertilization (hpf). By 36 hpf, expression is detected in discrete zones along each somitic boundary, between the PCV and the horizontal myoseptum, as well as along the horizontal myoseptum itself. At 48 hpf, expression is restricted along the horizontal myoseptum.
messages: Secreted

7955:pafah1b1a
gene id: 7955:pafah1b1a
uniprot id: B2GQS8
uniprot id: Q7T394
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Can self-associate. Component of the cytosolic PAF-AH (I) heterotetrameric enzyme, which is composed of PAFAH1B1 (beta), PAFAH1B2 (alpha2) and PAFAH1B3 (alpha1) subunits. The catalytic activity of the enzyme resides in the alpha1 (PAFAH1B3) and alpha2 (PAFAH1B2) subunits, whereas the beta subunit (PAFAH1B1) has regulatory activity. Trimer formation is not essential for the catalytic activity (By similarity). Interacts with dynein, dynactin, nde1 and ndel1.
messages: Can self-associate. Interacts with dynein, dynactin, NDE1 and NDEL1.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
messages: Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
messages: centrosome
messages: cytoskeleton

7955:zgc:114041
gene id: 7955:zgc:114041
uniprot id: Q4KM10
names: Subcellular Location Annotation
messages: Membrane

7955:cntnap5a
gene id: 7955:cntnap5a
uniprot id: A0A8M3AW13
uniprot id: A0A8M3BCG4
names: Caution
names: Similarity
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:si:dkey-27p23.3
gene id: 7955:si:dkey-27p23.3
uniprot id: A0A8M3B9Y1
uniprot id: A0A8M6YYA3
uniprot id: A5PN52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HOATZ family.
messages: Cytoplasm
messages: May be required for motile ciliogenesis and flagellar genesis.
messages: cilium

7955:zgc:92380
gene id: 7955:zgc:92380
uniprot id: E7FAL7
uniprot id: Q6DBU4
names: Similarity
messages: Belongs to the intermediate filament family.

7955:naa30
gene id: 7955:naa30
uniprot id: B3DIS0
uniprot id: F1RAT9
names: Similarity
messages: Belongs to the acetyltransferase family. MAK3 subfamily.

7955:plaua
gene id: 7955:plaua
uniprot id: A0A8M6Z265
uniprot id: D3GE88
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:fam102ab
gene id: 7955:fam102ab
uniprot id: A0A8M3ASJ7
uniprot id: A0A8M3B9P8
uniprot id: A2CEP8
uniprot id: Q08CL0
names: Similarity
messages: Belongs to the EEIG family.

7955:rab38
gene id: 7955:rab38
uniprot id: A0A8M9PIV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

7955:sass6
gene id: 7955:sass6
uniprot id: A0A8M2BL83
uniprot id: A0A8M3AM46
uniprot id: B2GRL0
uniprot id: Q7ZVT3
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Central scaffolding component of the centrioles ensuring their 9-fold symmetry (PubMed:21273447). Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (By similarity).
messages: Nine homodimers form a cartwheel structure with an internal diameter of 23 nM and radial spokes connecting to the microtubule triplets.
messages: The 35 nM long coiled-coil domain mediates homodimerization while the globular N-terminus links the dimers at an angle of 40 degrees to form the inner ring.
messages: centrosome

7955:pdgfrl
gene id: 7955:pdgfrl
uniprot id: F1QHI8
names: Subunit
messages: Forms a complex composed of PDGFRL, TNK2 and GRB2.

7955:cnn2
gene id: 7955:cnn2
uniprot id: A0A8M9Q784
uniprot id: Q6PBA5
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

7955:tm7sf2
gene id: 7955:tm7sf2
uniprot id: Q5PR41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

7955:si:dkey-151g10.3
gene id: 7955:si:dkey-151g10.3
uniprot id: A0A8M9P5H4
uniprot id: A0A8M9PFG8
uniprot id: A0A8M9PL63
uniprot id: A0A8M9PTI7
uniprot id: A0A8M9PWV5
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

7955:sult3st3
gene id: 7955:sult3st3
uniprot id: Q1L872
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

7955:mslna
gene id: 7955:mslna
uniprot id: A0A8M9PTN4
uniprot id: A0A8M9PZM5
uniprot id: A0A8M9QAJ5
names: Similarity
messages: Belongs to the mesothelin family.

7955:phf10
gene id: 7955:phf10
uniprot id: Z4YI11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAYP family.
messages: Nucleus

7955:lss
gene id: 7955:lss
uniprot id: A4FVM4
names: Similarity
messages: Belongs to the terpene cyclase/mutase family.

7955:aldh5a1
gene id: 7955:aldh5a1
uniprot id: A0A0R4IIB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
messages: Homotetramer.
messages: Mitochondrion

7955:znf219
gene id: 7955:znf219
uniprot id: F1QQA8
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: C2H2-type zinc-finger domains 6 and 9 are important for binding to the GGGGG motif in target DNA, and for the interaction with sox9a.
messages: Detected in the notochord at 22-48 hours post-fertilization (hpf). Expressed in otic vesicles and pectoral fin at 48 hpf. Expressed in the hindbrain and midbrain-hindbrain boundary at 48-96 hpf.
messages: Highly expressed in heart and brain. Also detected at lower levels in muscle and testis.
messages: Interacts with sox9a.
messages: Morpholino knockdown of the protein results in a curved body axis (PubMed:24155663). Expression of col2a1a and sncgb in the developing notochord at 24 hours post-fertilization is significantly reduced (PubMed:24155663, PubMed:24269816).
messages: Nucleus
messages: Transcriptional regulator (PubMed:24155663, PubMed:24269816). Recognizes and binds to the core DNA sequence motif 5'-GGGGG-3' (PubMed:24155663, PubMed:24269816). Binds to the col2a1a promoter and activates col2a1a expression (PubMed:24155663). Binds to the sncgb promoter and activates sncgb expression, as part of a complex with sox9a (PubMed:24269816).

7955:LOC799194
gene id: 7955:LOC799194
uniprot id: A0A8M1PZB9
uniprot id: E7F2G5
names: Subcellular Location Annotation
messages: Membrane

7955:lbx2
gene id: 7955:lbx2
uniprot id: Q804R0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Expressed in the germ ring at the blastoderm margin during the shield stage and when embryo reaches 80% epiboly stage of gastrulation, expression is higher dorsally than ventrally (PubMed:19216761, PubMed:22406073). Expressed in the paraxial mesoderm, posterior lateral mesoderm and adaxial cells at the end of the bud stage (PubMed:19216761, PubMed:22216300). Expressed in the segmental plate and ventral mesoderm during early gastrulation and early somitogenesis (PubMed:25371059). Expressed at the posterior dorsal midline at the three-somite stage and extends to the anterior region along the notochord, and to the trunk somites and cells lateral to them in the 24 hours post-fertilization (hpf) (PubMed:22406073). Expressed in both dorsal and ventral fast muscle cells in the late stages of segmentation (PubMed:19216761). Expressed in the hindbrain, a subpopulation of spinal cord interneurons, hypaxial muscles and in migrating muscle cells giving rise to the hyoid muscles and pectoral fin muscles at 24 hpf (PubMed:25371059). Expressed in the neural tube and hindbrain at 36 and 48 hpf with additional expression in the pectoral fin bud and fin muscles at 48 hpf (PubMed:19216761, PubMed:22406073). Expression is lost from the trunk at 48 hpf (PubMed:19216761).
messages: Interacts (via N-terminus) with tle3a/gro2 (via C-terminus).
messages: Morpholino knockdown results in circling swimming behavior at the larval stage (PubMed:22216300). Reduced fin bud formation and loss of myod1 expression in embryo hyoid muscles (PubMed:19216761, PubMed:22216300, PubMed:22406073). Disruption of cuboidal morphology of adaxial cell pseudo-epithelium, and failure of myod1-expressing cells to incorporate into the adaxial cell layer (PubMed:19216761). Slow muscle fibers are abnormally shaped at 24 hpf and 48 hpf and fast muscle cells form shorter myofibrils at 24 hpf and 48 hpf, in addition unfused fast muscles cells are present at 48 hpf (PubMed:19216761). Reduced expression of thin filament genes in skeletal muscles and thick filament genes in embryos (PubMed:19216761). Weak and discontinuous pattern of cxcl12a/sdf1a expression just before the posterior lateral line (PLL) begins to migrate in the posterior lateral mesoderm at the tail bud stage, and in adaxial cells at the 10-somite stage (PubMed:22216300). Disruption of myoseptum distribution as a result of abnormal differentiation of cxcl12a/sdf1a-expressing cells in the horizontal myoseptum at 24 hpf (PubMed:22216300). Increase in cell death rate in the PLL primordium and deposited neuromasts at 36 hpf (PubMed:22216300). Decrease in the number of PLL neuromasts with 15% of morphants showing complete loss of neuromasts at 48 hpf (PubMed:22216300). The speed of PLL primordium migration is reduced and neuromasts are deposited at inappropriate locations along the length of the posteriorly extending primordium (PubMed:22216300). Disruption of the discrete dorsoventral domains resulting in narrowing of the mediolateral region and slower extension of the expression domains towards the dorsal region at the shield stage (PubMed:22406073). Abnormal anterior-posterior axis, reduced dorsalward movement speed of lateral marginal cells and reduced wnt5b expression at the end of gastrulation. Embryos have a broader neural plate in the neuroectoderm with shorter and broader notochor…
messages: Nucleus
messages: Transcription factor required in several developmental processes (PubMed:19216761, PubMed:22216300, PubMed:25371059). Involved in axis formation during embryonic development by inhibiting tle3a/gro2 from binding to tcf7l1a, thereby facilitating ctnnb1-mediated transcription of canonical Wnt/CTNNB1 signaling target genes (PubMed:25371059). Regulates convergent extension movements and hypaxial myogenesis during gastrulation by activating non-canonical Wnt signaling via wnt5b (PubMed:19216761, PubMed:22406073). Required for the formation of myofibrils and fusion of fast muscle precursor cells, potentially via transcriptional regulation of genes specific to thick and thin myofilaments (PubMed:19216761). Regulates the migration of the posterior lateral line primordium during embryonic development, possibly via regulation of cxcl12a/sdf1a expression in the posterior lateral mesoderm, thereby modulating the deposition of neuromasts at correct intervals (PubMed:22216300).

7955:slc27a2a
gene id: 7955:slc27a2a
uniprot id: Q4KMC7
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

7955:lifra
gene id: 7955:lifra
uniprot id: A0A0R4IE17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

7955:si:ch211-85n16.4
gene id: 7955:si:ch211-85n16.4
uniprot id: A0A8M6YZM7
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

7955:tfpi2
gene id: 7955:tfpi2
uniprot id: Q1WCN6
names: Subcellular Location Annotation
messages: Secreted

7955:nell2a
gene id: 7955:nell2a
uniprot id: A1A5Y0
names: Subcellular Location Annotation
messages: Secreted

7955:dnaaf3l
gene id: 7955:dnaaf3l
uniprot id: I6L846
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAAF3 family.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia.

7955:or111-5
gene id: 7955:or111-5
uniprot id: O42605
names: Subcellular Location Annotation
messages: Membrane

7955:LOC571502
gene id: 7955:LOC571502
uniprot id: A0A8M9P8Q0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:arr3b
gene id: 7955:arr3b
uniprot id: Q6PBM9
names: Similarity
messages: Belongs to the arrestin family.

7955:pbx1a
gene id: 7955:pbx1a
uniprot id: A0A8M6Z2J2
uniprot id: Q9I9B6
uniprot id: Q9I9B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

7955:mapk6
gene id: 7955:mapk6
uniprot id: Q0H1F2
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

7955:mdka
gene id: 7955:mdka
uniprot id: Q9W767
names: Similarity
messages: Belongs to the pleiotrophin family.

7955:gpr132b
gene id: 7955:gpr132b
uniprot id: A0A0R4IEK2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:wdr24
gene id: 7955:wdr24
uniprot id: A0A8M2B9U3
uniprot id: Q7ZVL2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR24 family.
messages: Catalytic component of the GATOR2 complex, a multiprotein complex that acts as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as a E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. In addition to its role in regulation of the mTORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux. Within the GATOR2 complex, WDR24 constitutes the catalytic subunit that mediates 'Lys-6'-linked ubiquitination of NPRL2.
messages: Component of the GATOR2 subcomplex, composed of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR2 complex interacts with CASTOR1 and CASTOR2; the interaction is negatively regulated by arginine. The GATOR2 complex interacts with SESN1, SESN2 and SESN3; the interaction is negatively regulated by amino acids.
messages: Lysosome membrane
messages: The GATOR2 complex is negatively regulated by the upstream amino acid sensors CASTOR1 and SESN2, which sequester the GATOR2 complex in absence of amino acids. In the presence of abundant amino acids, GATOR2 is released from CASTOR1 and SESN2 and activated.

7955:si:dkey-13p1.4
gene id: 7955:si:dkey-13p1.4
uniprot id: A0A8M2B5B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM151 family.
messages: Membrane

7955:siah1
gene id: 7955:siah1
uniprot id: A0A0H2UKD5
uniprot id: A0A0R4IPD0
uniprot id: Q7ZVG6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates.
messages: Homodimer.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the homodimerization and the interaction with substrate proteins. It is related to the TRAF family.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

7955:mmab
gene id: 7955:mmab
uniprot id: A2BGN0
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

7955:mboat1
gene id: 7955:mboat1
uniprot id: A0A0R4IZC9
uniprot id: A0A8M9P802
names: Subcellular Location Annotation
messages: Membrane

7955:khsrp
gene id: 7955:khsrp
uniprot id: A0A8M2B6Z8
uniprot id: A4QP88
names: Subcellular Location Annotation
messages: Nucleus

7955:sprtn
gene id: 7955:sprtn
uniprot id: A0A0G2L7I0
names: Activity Regulation
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autocatalytically cleaved in response to double-stranded DNA-binding: autocatalytic cleavage takes place in trans and leads to inactivation.
messages: Belongs to the Spartan family.
messages: Chromosome
messages: DNA-binding activates the protease activity: single-stranded DNA-binding specifically activates ability to cleave covalent DNA-protein cross-links (DPCs). In contrast, double-stranded DNA-binding specifically activates autocatalytic cleavage, and subsequent inactivation.
messages: DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity (By similarity). DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde. Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis. Acts as a pleiotropic protease for DNA-binding proteins cross-linked with DNA, such as top1, top2a, histones H3 and H4 (By similarity). Mediates degradation of DPCs that are not ubiquitinated, while it is not able to degrade ubiquitinated DPCs. SPRTN activation requires polymerase collision with DPCs followed by helicase bypass of DPCs (By similarity). May also act as a 'reader' of ubiquitinated pcna: facilitates chromatin association of rad18 and is required for efficient pcna monoubiquitination, promoting a feed-forward loop to enhance pcna ubiquitination and translesion DNA synthesis. Acts as a regulator of translesion DNA synthesis by recruiting vcp/p97 to sites of DNA damage (By similarity).
messages: Homodimer.
messages: Morpholino knockdown of the protein causes severe development defects and accumulation of DNA damage.
messages: Nucleus
messages: The UBZ4-type zinc fingers mediate binding to 'Lys-48'- and 'Lys-63'-linked polyubiquitin.

7955:plk1
gene id: 7955:plk1
uniprot id: Q4KMI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Midbody
messages: Nucleus
messages: centrosome

7955:kcnh6b
gene id: 7955:kcnh6b
uniprot id: A0A8M9QEL7
names: Subcellular Location Annotation
messages: Membrane

7955:pim2
gene id: 7955:pim2
uniprot id: Z4YHY2
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

7955:cebpg
gene id: 7955:cebpg
uniprot id: Q8UVY8
names: Similarity
messages: Belongs to the bZIP family. C/EBP subfamily.

7955:patl1
gene id: 7955:patl1
uniprot id: A2RRV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PAT1 family.
messages: Interacts with ribonucleoprotein complex components.
messages: Nucleus
messages: Nucleus speckle
messages: P-body
messages: PML body
messages: RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly.

7955:bbs10
gene id: 7955:bbs10
uniprot id: A0A286Y9A6
uniprot id: A4QP63
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

7955:si:ch1073-159d7.7
gene id: 7955:si:ch1073-159d7.7
uniprot id: A0A140LH34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

7955:ppp1r1b
gene id: 7955:ppp1r1b
uniprot id: A0A0R4I9N8
uniprot id: E7F7T1
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

7955:LOC101886447
gene id: 7955:LOC101886447
uniprot id: A0A8M6YWJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Secreted

7955:chadla
gene id: 7955:chadla
uniprot id: E7EXH9
names: Similarity
messages: Belongs to the Toll-like receptor family.

7955:nme5
gene id: 7955:nme5
uniprot id: Q6DGQ8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia.
messages: Morpholino knockdown of the gene in embryos results in ciliopathic phenotypes, including a ventrally curved trunk, small eyes, otolith defects, hydrocephalus, and reversed heart looping. In the spine of mutant animals, the cilia of the central canal form normally and there are no changes in the length or number of cilia, indicating that the gene is not required for ciliary development. However, the beating movement of motile cilia is rarely observed in mutant animals.
messages: cilium

7955:sh3gl2b
gene id: 7955:sh3gl2b
uniprot id: A0A8M1NYJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

7955:mical1
gene id: 7955:mical1
uniprot id: E5F2M3
uniprot id: E7F9T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mical family.
messages: Cytoplasm
messages: Endosome membrane
messages: Midbody
messages: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and prevent repolymerization. May be involved in endosomal tubule extension and neosynthesized protein export (By similarity).
messages: cytoskeleton

7955:anxa2b
gene id: 7955:anxa2b
uniprot id: A8E5G1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Membrane
messages: basement membrane

7955:cdh26.1
gene id: 7955:cdh26.1
uniprot id: E7F370
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane

7955:lpar1
gene id: 7955:lpar1
uniprot id: Q6DHQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cell surface
messages: Endosome
messages: Membrane

7955:tmem115
gene id: 7955:tmem115
uniprot id: Q1LVD9
uniprot id: Q4V8Z5
names: Subcellular Location Annotation
messages: Membrane

7955:gsto1
gene id: 7955:gsto1
uniprot id: Q6DHK5
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

7955:hsd20b2
gene id: 7955:hsd20b2
uniprot id: A2BFP6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:kctd6b
gene id: 7955:kctd6b
uniprot id: Q6DG99
names: Function
names: Subunit
messages: Homopentamer. May be part of a cullin-containing E3 ubiquitin-protein ligase complex.
messages: Probable substrate-specific adapter of a cullin-containing E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins.

7955:LOC101882231
gene id: 7955:LOC101882231
uniprot id: A0A8M2B5C4
uniprot id: A0A8M3B216
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted

7955:psmd7
gene id: 7955:psmd7
uniprot id: Q7ZYX7
names: Similarity
messages: Belongs to the peptidase M67A family.

7955:tubgcp4
gene id: 7955:tubgcp4
uniprot id: B3DIU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

7955:mnx2a
gene id: 7955:mnx2a
uniprot id: B3DHA2
names: Subcellular Location Annotation
messages: Nucleus

7955:ncaph
gene id: 7955:ncaph
uniprot id: A0A8M9PKI5
uniprot id: A1L231
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND2 (condensin subunit 2) family.
messages: Chromosome
messages: Cytoplasm
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.

7955:wdr76
gene id: 7955:wdr76
uniprot id: A0A8M9Q1Q9
uniprot id: E7FER1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Interacts with CUL4A and/or CUL4B.
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

7955:adck2
gene id: 7955:adck2
uniprot id: A0A8M9PXA8
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

7955:opn1mw4
gene id: 7955:opn1mw4
uniprot id: Q9W6A6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
messages: Retinal double cone accessory photoreceptor cell outer segments.
messages: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

7955:camkk1a
gene id: 7955:camkk1a
uniprot id: A0A8M2BJ77
uniprot id: A2BIP2
uniprot id: Q58EH5
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:six9
gene id: 7955:six9
uniprot id: B3DI74
names: Subcellular Location Annotation
messages: Nucleus

7955:zgc:158320
gene id: 7955:zgc:158320
uniprot id: A0PJR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: nucleoplasm

7955:tcp11l2
gene id: 7955:tcp11l2
uniprot id: Q5RGW3
uniprot id: Q6P4P3
names: Similarity
messages: Belongs to the TCP11 family.

7955:glulb
gene id: 7955:glulb
uniprot id: Q7ZVF2
names: Similarity
messages: Belongs to the glutamine synthetase family.

7955:fbl
gene id: 7955:fbl
uniprot id: Q7ZTZ4
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

7955:rtca
gene id: 7955:rtca
uniprot id: Q7ZUX5
names: Function
names: Similarity
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.

7955:kdrl
gene id: 7955:kdrl
uniprot id: A0A8M3AGQ5
uniprot id: Q8AXB3
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: First expressed in embryos between 5- and 7-somites. At 7 somites, expressed in discrete bilateral stripes both anteriorly and posteriorly, and in a transverse ectodermal stripe in the hindbrain. From 7-somites, expression seems to extend caudally from the head, and in both directions in the trunk region, until by 20-somites, expression is detected as a continuous band from the anterior head region to the tailbud. Concurrently, cells expressing kdrl in the mid- and posterior trunk regions converge medially. By 24 hours post-fertilization (hpf), expressed in all the endothelial cells lining the vasculature.
messages: Interacts with isoform VEGF165 of vegfaa and isoform VEGF171 of vegfab.
messages: Membrane
messages: Phosphorylated and activated by vegfaa and vegfab.
messages: Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis.
messages: Was originally thought to be an ortholog of KDR, but PubMed:18516225 has shown that it represents a fourth vertebrate vascular endothelial growth factor receptor (VEGFR) that is not present in eutherian mammals (marsupials and placental mammals).

7955:dusp2
gene id: 7955:dusp2
uniprot id: Q6DBR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

7955:cpne3
gene id: 7955:cpne3
uniprot id: A0A0R4IUW1
uniprot id: F1Q9D2
uniprot id: Q7ZVU4
names: Similarity
messages: Belongs to the copine family.

7955:pcdh2g29
gene id: 7955:pcdh2g29
uniprot id: B3DGB1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

7955:LOC100537055
gene id: 7955:LOC100537055
uniprot id: A0A8M1RST6
names: Similarity
messages: Belongs to the cornifelin family.

7955:il12rb2l
gene id: 7955:il12rb2l
uniprot id: E7FH62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

7955:sqlea
gene id: 7955:sqlea
uniprot id: A8E4T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the squalene monooxygenase family.
messages: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
messages: Endoplasmic reticulum membrane

7955:cdkn1ca
gene id: 7955:cdkn1ca
uniprot id: Q6IQT7
names: Similarity
messages: Belongs to the CDI family.

7955:cst14a.2
gene id: 7955:cst14a.2
uniprot id: A7MCL7
names: Similarity
messages: Belongs to the cystatin family.

7955:ppp3ca
gene id: 7955:ppp3ca
uniprot id: E9QD09
uniprot id: F1QD93
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

7955:iqcg
gene id: 7955:iqcg
uniprot id: A0A8M1RMF7
uniprot id: A3KQH2
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DRC9 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC) (By similarity). Interacts (via IQ domain) with calmodulin when calcium levels are low. Does not interact with calmodulin in the presence of Ca(2+). Interacts with hsp70 and may form a complex with camk4 and hsp70 (PubMed:24787902).
messages: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (camk4) activity; contributes to the regulation of camk4 signaling cascades. Plays a role in the regulation of definitive hematopoiesis via its effects on camk4 (PubMed:24787902).
messages: Cytoplasm
messages: Detected in adult testis, and at lower levels in brain, kidney and ovary.
messages: Morpholino knockdown of the protein leads to a severe reduction in the size of the caudal hematopoietic tissue at 72 hpf, a strong reduction in the number of myb-positive hematopoietic stem cells, and results in impaired definitive hematopoiesis. Contrary to wild-type, the expression of monocyte, macrophage and lymphoblast markers is strongly reduced. Likewise, hemoglobin levels are strongly reduced, suggesting impaired erythropoiesis.
messages: The IQ domain mediates interaction with calmodulin when cellular Ca(2+) levels are low.
messages: cilium
messages: cytoskeleton
messages: flagellum
messages: flagellum axoneme

7955:slco1d1
gene id: 7955:slco1d1
uniprot id: A0A8M9PU70
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:LOC101884238
gene id: 7955:LOC101884238
uniprot id: A0A8M9PKH3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:myo1b
gene id: 7955:myo1b
uniprot id: A0A8M1QLB6
uniprot id: A0A8M1RIU5
uniprot id: A0A8M2BFD8
uniprot id: A0A8M2BFF2
uniprot id: A0A8M2BFG0
uniprot id: A0A8M2BG11
uniprot id: A0A8M3AVX4
uniprot id: A0A8M3B2K3
uniprot id: A0A8M3B5I5
uniprot id: F1R617
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:npas4b
gene id: 7955:npas4b
uniprot id: E7FFX1
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Contains a degenerate basic motif not likely to bind DNA.
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus
messages: Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hippocampus. Plays a key role in the structural and functional plasticity of neurons. Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience.

7955:mfsd8
gene id: 7955:mfsd8
uniprot id: A0A8M3BE48
uniprot id: Q0VA82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Lysosome membrane
messages: May be a carrier that transport small solutes by using chemiosmotic ion gradients.
messages: Membrane

7955:sb:cb829
gene id: 7955:sb:cb829
uniprot id: A0A8M1QHU1
uniprot id: E7FDW8
names: Function
names: Subcellular Location Annotation
messages: Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Probably required during spermatogenesis (By similarity).
messages: Cytoplasm

7955:dctn1b
gene id: 7955:dctn1b
uniprot id: A0A8M3AYX5
uniprot id: A0A8M3B541
uniprot id: A0A8M3B7W5
uniprot id: A0A8M3BEJ1
uniprot id: A0A8M9QFT7
uniprot id: A0A8M9QK32
uniprot id: A0A8M9QNN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin 150 kDa subunit family.
messages: cell cortex
messages: cytoskeleton

7955:tcirg1a
gene id: 7955:tcirg1a
uniprot id: B8A655
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

7955:tmub1
gene id: 7955:tmub1
uniprot id: Q6P135
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity). The membrane form is involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR. May be involved in centrosome assembly.
messages: Membrane
messages: Nucleus

7955:vipb
gene id: 7955:vipb
uniprot id: A0A8M9Q6Y9
uniprot id: B0LF71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

7955:si:dkey-261m9.6
gene id: 7955:si:dkey-261m9.6
uniprot id: X1WHF1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:paqr3b
gene id: 7955:paqr3b
uniprot id: A0A8M2B2D6
uniprot id: F1QC00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

7955:drl
gene id: 7955:drl
uniprot id: Q9W747
names: Tissue Specificity
messages: Specifically expressed in the hematopoietic lineage during embryogenesis; first expressed at the late blastula stage around the blastoderm margin. During gastrulation, restricted to the ventral mesoderm, the presumptive prechordal plate and the dorso-marginal cells of the organizer. At the 3-somite stage, strongly expressed in a caudal domain (marking the erythroid lineage) and a cephalic domain of the lateral mesoderm. At the 8- to 10-somite stage, caudal expression is in two bands of lateral mesoderm which later converge at the midline. Anterior expression is also in two bands of lateral mesoderm which converge as two patches at the midline by the 15-somite stage, with increased scattering of single cells (macrophage precursors) away from the midline to the yolksac. Once at the yolksac, expression is lost. By 20-24 hours post-fertilization (hpf), expressed in proerythroblasts in the erythroid blood island centered above the uro-genital opening. Expression persists in circulating erythroblasts but is lost in mature erythrocytes.

7955:phlda2
gene id: 7955:phlda2
uniprot id: B2GSF6
uniprot id: Q503L1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PHLDA2 family.
messages: Cytoplasm
messages: Membrane
messages: Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity).
messages: The PH domain binds phosphoinositides with a broad specificity. It may compete with the PH domain of some other proteins, thereby interfering with their binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity).

7955:slc25a23a
gene id: 7955:slc25a23a
uniprot id: A0A8M9Q1C3
uniprot id: A0A8M9QBS3
uniprot id: A0A8M9QBS8
uniprot id: A0A8N7T7N2
uniprot id: R4GDS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

7955:taf13
gene id: 7955:taf13
uniprot id: Q66I70
names: Subcellular Location Annotation
messages: Nucleus

7955:si:dkey-222f2.1
gene id: 7955:si:dkey-222f2.1
uniprot id: A0A8M9PVS9
uniprot id: F1RDG4
names: Similarity
messages: Belongs to the intermediate filament family.

7955:LOC110438378
gene id: 7955:LOC110438378
uniprot id: A0A8M9PYU0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:tbrg1
gene id: 7955:tbrg1
uniprot id: A0A8M1NHI5
uniprot id: A0A8M3AJR4
uniprot id: A0A8M9PQD4
uniprot id: A9JST2
names: Subcellular Location Annotation
messages: Nucleus

7955:tbr1b
gene id: 7955:tbr1b
uniprot id: B5DE34
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7955:pth1b
gene id: 7955:pth1b
uniprot id: Q6WQ24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parathyroid hormone family.
messages: Secreted

7955:slc35a4
gene id: 7955:slc35a4
uniprot id: A0A8M1P4A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

7955:LOC100538044
gene id: 7955:LOC100538044
uniprot id: A0A8M1RIG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

7955:ntng2a
gene id: 7955:ntng2a
uniprot id: A0A8M3BBM3
uniprot id: A0A8M9Q3R4
uniprot id: A0A8N7USZ4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:otol1a
gene id: 7955:otol1a
uniprot id: A5PN28
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OTOL1 family.
messages: Collagen-like protein, which provides an organic scaffold for otoliths onto the sensory epithelium of the inner ear (PubMed:15905077, PubMed:29076638). Acts as a scaffold for biomineralization by sequestering calcium (PubMed:29076638).
messages: Homooligomer; disulfide-linked; probably forms homotrimers (PubMed:29076638). Interacts with otomp (By similarity).
messages: The C1q domain mediates calcium-binding.
messages: extracellular matrix

7955:chrnb2a
gene id: 7955:chrnb2a
uniprot id: A0A8M3B0F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:ascl1b
gene id: 7955:ascl1b
uniprot id: Q90260
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: First detected at 10 hours post-fertilization (hpf) increasing over the next 24 hours, then decreasing between 48 and 72 hours. Not detected in adult.
messages: In the 24 hours embryo, expressed in hindbrain close to the anterior and posterior boundaries of rhombomeres 2-6 and in ventral cells close to the floor plate of most rhombomeres. Also expressed in the telencephalon, diencephalon, tegmentum and spinal cord at sites distinct from those expressing ascl1a. Not expressed in the adenohypophysis.
messages: Nucleus
messages: Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter (By similarity). Involved in neurogenesis. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. May mediate transcription activation by binding to the E box-containing promoter.

7955:galk2
gene id: 7955:galk2
uniprot id: E7FDP4
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

7955:erbb3b
gene id: 7955:erbb3b
uniprot id: A0A8M2B911
uniprot id: A0A8M9P541
uniprot id: Q5G254
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

7955:zfpm1
gene id: 7955:zfpm1
uniprot id: Q2QKK0
names: Subcellular Location Annotation
messages: Nucleus

7955:taar14l
gene id: 7955:taar14l
uniprot id: Q5RFY5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:lrp1ba
gene id: 7955:lrp1ba
uniprot id: A0A8M6YV36
uniprot id: A0A8M9PEH3
names: Caution
names: Similarity
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:susd1
gene id: 7955:susd1
uniprot id: A0A8M3ARY2
uniprot id: A0A8M9PYC1
uniprot id: F1QRX3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:pax10
gene id: 7955:pax10
uniprot id: I3IT91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

7955:zgc:101583
gene id: 7955:zgc:101583
uniprot id: F1QFZ6
uniprot id: Q5PRD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

7955:LOC562245
gene id: 7955:LOC562245
uniprot id: A0A8M9QG79
names: Similarity
messages: Belongs to the peptidase S1C family.

7955:inaa
gene id: 7955:inaa
uniprot id: A2ATX5
names: Similarity
messages: Belongs to the intermediate filament family.

7955:zmp:0000001048
gene id: 7955:zmp:0000001048
uniprot id: A0A8M2BB22
uniprot id: A0A8M3AR80
uniprot id: A0A8M3B8K5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:adamts3
gene id: 7955:adamts3
uniprot id: A0A8M6Z0H1
uniprot id: A0A8M9PJM4
uniprot id: S5RVW8
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

7955:si:dkey-175m17.6
gene id: 7955:si:dkey-175m17.6
uniprot id: F6NN34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:si:dkey-58b18.4
gene id: 7955:si:dkey-58b18.4
uniprot id: A0A8M3AX95
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.

7955:ing3
gene id: 7955:ing3
uniprot id: Q6TEM2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

7955:arf4b
gene id: 7955:arf4b
uniprot id: Q566Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

7955:eml2
gene id: 7955:eml2
uniprot id: Q4KMH7
names: Similarity
messages: Belongs to the WD repeat EMAP family.

7955:tmem106ba
gene id: 7955:tmem106ba
uniprot id: F1QCQ2
names: Similarity
messages: Belongs to the TMEM106 family.

7955:tmem245
gene id: 7955:tmem245
uniprot id: A0A8M1PSG2
uniprot id: A0A8M3B1Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

7955:tspan18b
gene id: 7955:tspan18b
uniprot id: A0A8M2B5N2
uniprot id: A0A8M6YU47
uniprot id: Q6DH58
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: First detected at early somitogenesis stage, 12 h post fertilization (hpf), in yolk marginal zone, and then specifically in the dorsal aorta (DA) and in yolk vessels at 24 hpf (PubMed:32694189). At 32 hpf, expression is observed in the DA, posterior cardinal vein (PCV), dorsal longitudinal anastomotic vessels (DLAV) and intersegmental vessel (ISV) (PubMed:32694189). Expression in these vessels is maintained through 32 hpf and then reduced from 32 to 48 hpf (PubMed:32694189). Expression is almost undetectable from 56 hpf to 4 days post fertilization (dpf) (PubMed:32694189).
messages: May regulate angiogenesis through KDR/VEGFR2 and NOTCH1 pathways.
messages: Membrane

7955:cdt1
gene id: 7955:cdt1
uniprot id: A0A8M6YZJ1
uniprot id: E7F2R5
names: Similarity
messages: Belongs to the Cdt1 family.

7955:LOC110440101
gene id: 7955:LOC110440101
uniprot id: A0A8M9Q7R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

7955:pdgfab
gene id: 7955:pdgfab
uniprot id: A0A8M2BAV6
uniprot id: Q08CD2
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

7955:ncstn
gene id: 7955:ncstn
uniprot id: Q5XLR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicastrin family.
messages: Membrane

7955:kcnh4b
gene id: 7955:kcnh4b
uniprot id: A0A8M6Z211
uniprot id: E7FB36
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

7955:slc35f1
gene id: 7955:slc35f1
uniprot id: F1Q4Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

7955:LOC110437972
gene id: 7955:LOC110437972
uniprot id: A0A8M9NZK9
uniprot id: A0A8M9P876
names: Subcellular Location Annotation
messages: Membrane

7955:vps29
gene id: 7955:vps29
uniprot id: A0A8M2B844
uniprot id: Q7ZV68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity). Acts also as component of the retriever complex. The retriever complex is an heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrins. In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (By similarity).
messages: Belongs to the VPS29 family.
messages: Component of the heterotrimeric retromer cargo-selective complex (CSC) which is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants (By similarity). Component of the heterotrimeric retriever complex (By similarity).
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

7955:slc17a7b
gene id: 7955:slc17a7b
uniprot id: A0A8M3ANT7
names: Subcellular Location Annotation
messages: Membrane

7955:pdhx
gene id: 7955:pdhx
uniprot id: A0A8M2BI02
uniprot id: F1R0J8
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

7955:ubap2b
gene id: 7955:ubap2b
uniprot id: A0A8M2BEK9
uniprot id: A0A8M2BFB5
uniprot id: A2RUY5
names: Subcellular Location Annotation
messages: Cytoplasm

7955:taar12a
gene id: 7955:taar12a
uniprot id: Q5QNQ2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:map6a
gene id: 7955:map6a
uniprot id: A0A2R8Q3V4
uniprot id: A0A8M3AWZ1
uniprot id: A0A8M3BD76
uniprot id: A0A8M9QH51
uniprot id: E7F624
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STOP family.
messages: cytoskeleton

7955:LOC100330380
gene id: 7955:LOC100330380
uniprot id: A0A8M9QD96
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:cmah
gene id: 7955:cmah
uniprot id: Q6GML1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMP-Neu5Ac hydroxylase family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Cytoplasm
messages: Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells.

7955:nme6
gene id: 7955:nme6
uniprot id: A0A8M9PHJ1
uniprot id: Q6DI51
names: Function
names: Similarity
messages: Belongs to the NDK family.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

7955:map4l
gene id: 7955:map4l
uniprot id: A0A0R4J7C3
uniprot id: A0A8M2BIJ0
uniprot id: A0A8M2BIK8
uniprot id: A0A8M2BIN5
uniprot id: A0A8M2BJ02
uniprot id: A0A8M9P945
uniprot id: E7FBI2
names: Subcellular Location Annotation
messages: cytoskeleton

7955:gabbr1a
gene id: 7955:gabbr1a
uniprot id: A0A8N7UVF8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:ano5b
gene id: 7955:ano5b
uniprot id: A0A8M2BGR8
uniprot id: A0A8M3BB15
uniprot id: A1A5Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

7955:galr2b
gene id: 7955:galr2b
uniprot id: A0A8M9PGK2
uniprot id: E7F7V7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Expressed in neurons in the ventral area of the interpeduncular nucleus (IPN) where expression often overlaps with spx1.
messages: In embryos, widely expressed in nerve cells innervating the central nervous system (CNS) in regions including the olfactory bulb, midbrain tegmentum, preoptic region, dorsal thalamus, posterior tuberculum, postoptic commissure, hindbrain, and lateral margin of the spinal cord (PubMed:27315774). In the spinal cord, expressed in various neuronal cell types throughout the dorsoventral axis, including motor neurons and interneurons (PubMed:27315774). In the postoptic commissure, anterior commissure, hypothalamus and pituitary gland, expression overlaps with gal (PubMed:27315774). In larvae, expressed in nerve cells in the dorsal spinal cord where expression often overlaps with spx1 (PubMed:30903017).
messages: Membrane
messages: Receptor for the hormone galanin (PubMed:24517231). Receptor for the hormones spexin-1 and spexin-2 (PubMed:24517231, PubMed:31474838).

7955:onecutl
gene id: 7955:onecutl
uniprot id: A2BF65
uniprot id: Q8UUX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

7955:LOC100536981
gene id: 7955:LOC100536981
uniprot id: A0A8M9Q5B1
uniprot id: A0A8M9QBM8
names: Similarity
messages: Belongs to the WAL family.

7955:cryaa
gene id: 7955:cryaa
uniprot id: Q8UUZ6
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

7955:cd36
gene id: 7955:cd36
uniprot id: Q6DHC7
names: Similarity
messages: Belongs to the CD36 family.

7955:syk
gene id: 7955:syk
uniprot id: A0A8M2B201
uniprot id: E9QFU7
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.

7955:si:dkey-228d14.5
gene id: 7955:si:dkey-228d14.5
uniprot id: B8A6A2
names: Subcellular Location Annotation
messages: Membrane

7955:meig1
gene id: 7955:meig1
uniprot id: A0A8M3AYL1
uniprot id: Q5RGE4
names: Function
names: Similarity
messages: Belongs to the MEIG1 family.
messages: Essential for spermiogenesis.

7955:porb
gene id: 7955:porb
uniprot id: A0A8M2BKN4
uniprot id: F8W4Z6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

7955:si:dkey-100n10.2
gene id: 7955:si:dkey-100n10.2
uniprot id: E7F7K0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

7955:prtga
gene id: 7955:prtga
uniprot id: Q2EY14
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the immunoglobulin superfamily. DCC family.
messages: Expression begins at 80% epiboly and is extinguished by 48 hours post-fertilization.
messages: Expression begins in the posterior region of the embryo and this posterior restriction persists at the 4 s stage. At early somite stages, expressed along the neural tube with lower levels in the lateral and paraxial mesoderm. Expression decreases caudally and rostrally becomes restricted to the ventral part of the brain. Widespread in the spinal cord at 30 hours post-fertilization (hpf) and is also expressed in the lens from this time. At 40 hpf, expression is restricted to the lens.
messages: May play a role in anteroposterior axis elongation.
messages: Membrane

7955:thy1
gene id: 7955:thy1
uniprot id: A0A8M9PJQ1
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

7955:cadm1b
gene id: 7955:cadm1b
uniprot id: B0F6R1
names: Similarity
messages: Belongs to the nectin family.

7955:zgc:55461
gene id: 7955:zgc:55461
uniprot id: Q7ZW01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

7955:best4
gene id: 7955:best4
uniprot id: A0A8N7UT59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

7955:slc5a12
gene id: 7955:slc5a12
uniprot id: Q7T384
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate.
messages: Apical cell membrane
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Expressed in brain and eye 24, 72 and 120 hours post-fertilization (hpf). At 72 hpf expressed in swim bladder and in pronephric tube. At 120 hpf expressed in brain, trabecular bar, eyes, otic capsule, stomach, gall bladder, gut and pancreas.

7955:dpy30
gene id: 7955:dpy30
uniprot id: B8JMZ3
names: Similarity
messages: Belongs to the dpy-30 family.

7955:si:dkey-22f5.9
gene id: 7955:si:dkey-22f5.9
uniprot id: E9QG21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEAP2 family.
messages: Has an antimicrobial activity.
messages: Secreted

7955:si:ch211-235e9.6
gene id: 7955:si:ch211-235e9.6
uniprot id: A0A0R4IV80
names: Similarity
names: Subunit
messages: Belongs to the complex I NDUFC1 subunit family.
messages: Complex I is composed of 45 different subunits.

7955:spsb1
gene id: 7955:spsb1
uniprot id: Q4V8W1
names: Similarity
messages: Belongs to the SPSB family.

7955:rnasel4
gene id: 7955:rnasel4
uniprot id: A5HAK2
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

7955:rrp8
gene id: 7955:rrp8
uniprot id: A0A8M6YSH0
uniprot id: F1R692
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RRP8 family.
messages: Probable methyltransferase required to silence rDNA.
messages: nucleolus

7955:hspa14
gene id: 7955:hspa14
uniprot id: Q5RGE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Component of ribosome-associated complex (RAC).
messages: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state.
messages: cytosol

7955:hapln4
gene id: 7955:hapln4
uniprot id: A0A8M2BHT5
uniprot id: Q1LV25
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:mmp17a
gene id: 7955:mmp17a
uniprot id: A0A8N7UVC2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

7955:nceh1b.1
gene id: 7955:nceh1b.1
uniprot id: A0JME8
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

7955:tmem136b
gene id: 7955:tmem136b
uniprot id: Q1LXV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TLCD5 family.
messages: Membrane

7955:fev
gene id: 7955:fev
uniprot id: A0A8M9QFM3
uniprot id: A0A8M9QJU5
uniprot id: A1L294
uniprot id: A3FEM2
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ETS family.
messages: Expressed by serotonergic neurons in anterior and posterior raphe.
messages: Expressed in post-mitotic raphe serotonergic neurons. First detected at the 20 somites stage.
messages: Functions as a transcriptional regulator. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth (By similarity).
messages: It is uncertain whether Met-1 or Met-14 is the initiator.
messages: Nucleus

7955:ppargc1a
gene id: 7955:ppargc1a
uniprot id: A0A8M1REN0
uniprot id: A0A8M6Z0A6
uniprot id: A0A8M6Z1V5
uniprot id: A0A8M6Z7F8
names: Subcellular Location Annotation
messages: Nucleus

7955:enpp1
gene id: 7955:enpp1
uniprot id: A0A8M1N7G9
uniprot id: A0A8M3B403
uniprot id: B0JZL7
names: Subcellular Location Annotation
messages: Secreted

7955:diaph2
gene id: 7955:diaph2
uniprot id: A0A8M9PZW8
uniprot id: A0A8M9QBN3
uniprot id: A0A8M9QGW2
uniprot id: A0A8M9QL38
uniprot id: A0A8M9QPK7
names: Similarity
messages: Belongs to the formin homology family. Diaphanous subfamily.

7955:dync2h1
gene id: 7955:dync2h1
uniprot id: A0A8M9PCL1
names: Similarity
messages: Belongs to the dynein heavy chain family.

7955:mea1
gene id: 7955:mea1
uniprot id: A0A8M2B2J6
uniprot id: Q6IQC5
names: Function
messages: May play an important role in spermatogenesis and/or testis development.

7955:pimr62
gene id: 7955:pimr62
uniprot id: A0A8M9PLQ8
uniprot id: A0A8M9PPT0
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:si:ch211-129c21.1
gene id: 7955:si:ch211-129c21.1
uniprot id: A0A8M2BHS6
uniprot id: M9MMA2
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:fam129bb
gene id: 7955:fam129bb
uniprot id: F1R7A2
names: Similarity
messages: Belongs to the Niban family.

7955:col27a1a
gene id: 7955:col27a1a
uniprot id: C7DZK3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the fibrillar collagen family.
messages: Expressed dynamically in the notochord from late epiboly, spreading to the anterior notochord by 24 hpf, and then throughout the notochord by 30 hpf. Subsequently, notochordal expression becomes restricted to the distal tip of the tail by 48 hpf and is no longer detectable by 72 hpf. Also expressed throughout the floor plate and hypochord at 24 hpf, and in forming head cartilages and the first forming tooth.
messages: May play a role during the calcification of cartilage and the transition of cartilage to bone (By similarity). Together with col27a1b, plays a role in development of the notochord and axial skeleton.
messages: The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity).
messages: extracellular matrix

7955:mapk9
gene id: 7955:mapk9
uniprot id: E9QE29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

7955:rps27a
gene id: 7955:rps27a
uniprot id: Q7SXA3
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.

7955:pax6a
gene id: 7955:pax6a
uniprot id: A0A0R4IXU2
uniprot id: A0A8M3AP00
uniprot id: A0A8M3APL7
uniprot id: A0A8M3AZJ7
uniprot id: A0A8M3B718
uniprot id: A0A8M6YYD0
uniprot id: A0A8M9P6C7
uniprot id: P26630
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the paired homeobox family.
messages: Nucleus
messages: Spatially restricted regions of the neural tube.
messages: Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development.

7955:zgc:173742
gene id: 7955:zgc:173742
uniprot id: A0A8M2BH93
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

7955:aldob
gene id: 7955:aldob
uniprot id: Q8JH71
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I fructose-bisphosphate aldolase family.
messages: Homotetramer.
messages: centriolar satellite

7955:mau2
gene id: 7955:mau2
uniprot id: A0A8M9P7C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC4/mau-2 family.
messages: nucleoplasm

7955:gria3b
gene id: 7955:gria3b
uniprot id: A0A286Y9Q6
uniprot id: A0A8M3B5M3
uniprot id: A0A8M9PZ43
uniprot id: Q71E60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

7955:purab
gene id: 7955:purab
uniprot id: A0A0R4I9N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

7955:LOC100536757
gene id: 7955:LOC100536757
uniprot id: A0A8M9Q9Z1
uniprot id: A0A8M9QIU5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:bcl9
gene id: 7955:bcl9
uniprot id: F1R405
uniprot id: Q67FY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

7955:gmppb
gene id: 7955:gmppb
uniprot id: F1R683
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

7955:hadhb
gene id: 7955:hadhb
uniprot id: Q7ZTH6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

7955:hsbp1b
gene id: 7955:hsbp1b
uniprot id: Q6PBV8
names: Similarity
messages: Belongs to the HSBP1 family.

7955:epb41a
gene id: 7955:epb41a
uniprot id: A0A8M3B3F1
names: Subcellular Location Annotation
messages: Nucleus
messages: cell cortex
messages: cytoskeleton

7955:ndor1
gene id: 7955:ndor1
uniprot id: F1R9Y7
uniprot id: Q6PFP6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: Interacts with CIAPIN1; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.
messages: Interacts with ciapin1; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair.
messages: NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of ciapin1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of cisd1 and activate this protein implicated in Fe/S cluster repair.
messages: perinuclear region

7955:id3
gene id: 7955:id3
uniprot id: Q8QFX4
names: Subcellular Location Annotation
messages: Nucleus

7955:optc
gene id: 7955:optc
uniprot id: A0A8M2BK46
uniprot id: Q15JE7
names: Similarity
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

7955:si:dkey-13e3.1
gene id: 7955:si:dkey-13e3.1
uniprot id: A9JRC1
names: Similarity
messages: Belongs to the peptidase C48 family.

7955:sfr1
gene id: 7955:sfr1
uniprot id: B7ZD04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SFR1/MEI5 family.
messages: Component of the swi5-sfr1 complex, a complex required for double-strand break repair via homologous recombination.
messages: Component of the swi5-sfr1 complex.
messages: Nucleus

7955:LOC100001665
gene id: 7955:LOC100001665
uniprot id: F1QGG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

7955:th2
gene id: 7955:th2
uniprot id: A0A8M2BBY7
uniprot id: Q6IVB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
messages: axon
messages: perinuclear region

7955:psmd11b
gene id: 7955:psmd11b
uniprot id: F1QGH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the proteasome subunit S9 family.
messages: Component of the lid subcomplex of the 19S proteasome regulatory particle complex (also named PA700 complex). The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits (By similarity).
messages: Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, psmd11b is required for proteasome assembly (By similarity).
messages: Nucleus
messages: cytosol

7955:engase
gene id: 7955:engase
uniprot id: A0A8M9P7C2
uniprot id: A0A8M9PHW8
uniprot id: A1L251
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 85 family.
messages: Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol (By similarity).
messages: cytosol

7955:msh5
gene id: 7955:msh5
uniprot id: A0A8M2B4N7
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.

7955:zmp:0000000932
gene id: 7955:zmp:0000000932
uniprot id: A0A8M6Z510
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:b4galt7
gene id: 7955:b4galt7
uniprot id: A0A8M9PZ57
uniprot id: Q6DRL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

7955:efnb2b
gene id: 7955:efnb2b
uniprot id: Q90Z32
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:si:ch73-1a9.3
gene id: 7955:si:ch73-1a9.3
uniprot id: A0A0R4IBX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

7955:LOC110439964
gene id: 7955:LOC110439964
uniprot id: A0A8M9Q995
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:ndufa1
gene id: 7955:ndufa1
uniprot id: F1QQ42
uniprot id: Q6IQP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA1 subunit family.
messages: Mitochondrion inner membrane

7955:stx16
gene id: 7955:stx16
uniprot id: A0A2R8Q071
uniprot id: A0A8M2BJE0
uniprot id: A0A8M9Q0Y1
uniprot id: A0A8M9QGE3
names: Similarity
messages: Belongs to the syntaxin family.

7955:mark4a
gene id: 7955:mark4a
uniprot id: A0A8M2BCN5
uniprot id: A0A8M2BCS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

7955:ube2d2l
gene id: 7955:ube2d2l
uniprot id: Q6PBX6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7955:htr1d
gene id: 7955:htr1d
uniprot id: C0ITM0
uniprot id: F1QAQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:rspo3
gene id: 7955:rspo3
uniprot id: A0A8M2B4I7
uniprot id: Q5R328
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway. Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity). Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 (By similarity).
messages: Belongs to the R-spondin family.
messages: Binds heparin.
messages: Secreted
messages: The FU repeats are required for activation and stabilization of beta-catenin.

7955:cyp2p7
gene id: 7955:cyp2p7
uniprot id: Q5TZ75
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:tmed2
gene id: 7955:tmed2
uniprot id: A0A8M9Q5S5
uniprot id: Q7ZW75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

7955:ate1
gene id: 7955:ate1
uniprot id: A0A8M9QKC3
names: Function
names: Similarity
messages: Belongs to the R-transferase family.
messages: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.

7955:LOC101882857
gene id: 7955:LOC101882857
uniprot id: A0A8M6YWZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

7955:otc
gene id: 7955:otc
uniprot id: E9QHD9
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
messages: Homotrimer.

7955:tmsb4x
gene id: 7955:tmsb4x
uniprot id: Q45QT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

7955:hoxd12a
gene id: 7955:hoxd12a
uniprot id: B0S5Y9
uniprot id: Q90471
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: First expressed at 14 hours post-fertilization (hpf) in the dorsal pre-somitic mesoderm and neural keel at posterior levels, extending into the ventral somitic mesoderm during budding. At 22-26 hpf, expression decreases in the lateral and ventral mesoderm, but is maintained in the neural rod. Expression decreases from posterior to anterior with an anterior expression limit at somite 17. Also expressed in the developing hindgut, except in the most distal portion. At 24-26 hpf, posterior expression begin to weaken and is undetectable by 40-56 hpf.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

7955:abcb8
gene id: 7955:abcb8
uniprot id: Q56A55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding subunit of the mitochondrial potassium channel located in the mitochondrial inner membrane. Together with CCDC51/MITOK, forms a protein complex localized in the mitochondria that mediates ATP-dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel) (By similarity). Plays a role in mitochondrial iron transport. Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (By similarity).
messages: Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
messages: Component of the mitochondrial potassium channel (mitoK(ATP)).
messages: Mitochondrion inner membrane

7955:mrpl17
gene id: 7955:mrpl17
uniprot id: Q66I81
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

7955:itprip
gene id: 7955:itprip
uniprot id: Q567X9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Cell membrane
messages: Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release.
messages: Nucleus outer membrane

7955:ebna1bp2
gene id: 7955:ebna1bp2
uniprot id: Q6DRD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP2 family.
messages: Required for the processing of the 27S pre-rRNA.
messages: nucleolus

7955:bco1
gene id: 7955:bco1
uniprot id: Q7ZTS0
names: Cofactor
names: Similarity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.

7955:cyp17a2
gene id: 7955:cyp17a2
uniprot id: A7U483
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:LOC100537813
gene id: 7955:LOC100537813
uniprot id: A0A8M3AYG5
names: Subcellular Location Annotation
messages: Membrane

7955:dtna
gene id: 7955:dtna
uniprot id: A0A8M2B9V6
uniprot id: A0A8M3ANS0
uniprot id: A0A8M6YW92
uniprot id: A0A8M6YY42
uniprot id: A0A8M6Z433
uniprot id: A0A8M6Z4Q5
uniprot id: A0A8M9P5Z6
uniprot id: A0A8M9PG52
uniprot id: A0A8M9PLX9
uniprot id: A0A8M9PU78
uniprot id: A0A8M9PXM8
uniprot id: A2CJ03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

7955:ripk2
gene id: 7955:ripk2
uniprot id: Q4V958
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.
messages: Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses. Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments.

7955:or128-2
gene id: 7955:or128-2
uniprot id: Q2PRG3
names: Subcellular Location Annotation
messages: Membrane

7955:nhsl1b
gene id: 7955:nhsl1b
uniprot id: A0A8M1RP42
uniprot id: A0A8M2B7N1
uniprot id: A0A8M2B7Q2
uniprot id: A0A8M2B7Q5
uniprot id: A0A8M2B7W5
uniprot id: A0A8M3AKZ2
uniprot id: E7EXR7
names: Similarity
messages: Belongs to the NHS family.

7955:timm23b
gene id: 7955:timm23b
uniprot id: A0A0J9YJ60
names: Subcellular Location Annotation
messages: Membrane

7955:rnd3a
gene id: 7955:rnd3a
uniprot id: Q6PC71
names: Function
messages: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

7955:myo18aa
gene id: 7955:myo18aa
uniprot id: A0A0R4J7R2
uniprot id: A0A8M3AX31
uniprot id: A0A8M3AX53
uniprot id: A0A8M3B6I5
uniprot id: A0A8M3BDA6
uniprot id: A0A8M9PUB6
uniprot id: A0A8M9Q6N9
uniprot id: A0A8M9QCN6
uniprot id: A0A8M9QH80
uniprot id: A0A8M9QL86
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:zpr1
gene id: 7955:zpr1
uniprot id: Q7ZTY3
names: Similarity
messages: Belongs to the ZPR1 family.

7955:stx12
gene id: 7955:stx12
uniprot id: A5PMJ7
uniprot id: Q6IQS7
names: Similarity
messages: Belongs to the syntaxin family.

7955:LOC561565
gene id: 7955:LOC561565
uniprot id: A0A8M9PL57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

7955:sec24b
gene id: 7955:sec24b
uniprot id: A0A2R8QCB9
uniprot id: E7F715
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

7955:mcm8
gene id: 7955:mcm8
uniprot id: A0A8M9P0B2
uniprot id: E7F643
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

7955:prpf4ba
gene id: 7955:prpf4ba
uniprot id: B0V1K6
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
messages: Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.

7955:klhl12
gene id: 7955:klhl12
uniprot id: Q5U374
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPII-coated vesicle
messages: Component of the BCR(KLHL12) E3 ubiquitin ligase complex.
messages: Expressed ubiquitously throughout development.
messages: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division (By similarity). Negatively regulates the Wnt signaling pathway, possibly via the targeted ubiquitination and subsequent proteolysis of dvl2 and dvl3 (PubMed:16547521). Regulates convergent-extension movements during early embryonic development (PubMed:16547521).

7955:grhpra
gene id: 7955:grhpra
uniprot id: Q504F9
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

7955:chrna1
gene id: 7955:chrna1
uniprot id: Q98880
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-1/CHRNA1 sub-subfamily.
messages: Cell membrane
messages: One of the alpha chains that assemble within the acetylcholine receptor, a pentamer of two alpha chains, a beta, a delta, and a gamma or epsilon chains.
messages: Postsynaptic cell membrane
messages: Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

7955:si:ch211-127b11.1
gene id: 7955:si:ch211-127b11.1
uniprot id: Q5RHX7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:zgc:195633
gene id: 7955:zgc:195633
uniprot id: F1QTL1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:ubtd2
gene id: 7955:ubtd2
uniprot id: Q6DG43
names: Subcellular Location Annotation
messages: Cytoplasm

7955:hspb11
gene id: 7955:hspb11
uniprot id: A0A0R4I9A8
uniprot id: A5JV83
names: Induction
names: Similarity
names: Tissue Specificity
messages: Belongs to the small heat shock protein (HSP20) family.
messages: By heat shock in the somites.
messages: Expressed specifically in the rostral-most somites at 24 hpf. At 48 hpf, expression continues in the rostral-most somites and also in the notochord. Somite expression was restricted to the vicinity of the horizontal myoseptum. In adults, expressed in the heart.

7955:ora3
gene id: 7955:ora3
uniprot id: A0A8M3AUC1
uniprot id: F1QTB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

7955:LOC563036
gene id: 7955:LOC563036
uniprot id: A0A8M1QUM8
names: Similarity
messages: Belongs to the MHC class I family.

7955:lrit2
gene id: 7955:lrit2
uniprot id: Q504C1
names: Subcellular Location Annotation
messages: Membrane

7955:homer1b
gene id: 7955:homer1b
uniprot id: A0A0R4INT7
uniprot id: A0A8M2B3L5
uniprot id: A0A8M9Q8D4
uniprot id: B8JIC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

7955:pnp6
gene id: 7955:pnp6
uniprot id: Q1LWJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

7955:rabep2
gene id: 7955:rabep2
uniprot id: F1Q793
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rabaptin family.
messages: Cytoplasm
messages: Early endosome
messages: Endosome

7955:extl3
gene id: 7955:extl3
uniprot id: Q5U7D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane

7955:taar14b
gene id: 7955:taar14b
uniprot id: Q5RG91
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:sox19b
gene id: 7955:sox19b
uniprot id: Q9DDD7
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Expressed both maternally and zygotically. Distributed throughout the blastoderm at the blastua stage but becomes confined to the future ectoderm by the shield stage. Expressed in the presumptive neuroectoderm at the 75-80% epiboly stage. From the tail bud to the 3-somite stage, expressed throughout the neural plate, except in the anterior margin. At the 12- to 25-somite stage, expressed broadly in the central nervous system.
messages: Nucleus
messages: Transcriptional activator.

7955:pde6b
gene id: 7955:pde6b
uniprot id: E7F5I9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

7955:ccr9a
gene id: 7955:ccr9a
uniprot id: B0V1K7
uniprot id: Q568F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Membrane

7955:ldhba
gene id: 7955:ldhba
uniprot id: Q9PVK4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Cytoplasm
messages: Homotetramer.

7955:uqcc3
gene id: 7955:uqcc3
uniprot id: B3DFP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex).
messages: Belongs to the UQCC3 family.
messages: Mitochondrion inner membrane
messages: Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology.

7955:igfbp1b
gene id: 7955:igfbp1b
uniprot id: A4IGH0
uniprot id: A4K8J2
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds equally well IGF1 and IGF2.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:cers1
gene id: 7955:cers1
uniprot id: F1Q5B1
names: Subcellular Location Annotation
messages: Membrane

7955:tspan14
gene id: 7955:tspan14
uniprot id: A0A8M9PY57
uniprot id: Q0P407
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7955:med17
gene id: 7955:med17
uniprot id: B2GSS8
uniprot id: Q08BY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

7955:pcgf1
gene id: 7955:pcgf1
uniprot id: Q7ZYZ7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of a PRC1-like complex.
messages: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
messages: Nucleus

7955:rhd
gene id: 7955:rhd
uniprot id: Q4VV70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Cell membrane
messages: Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill.
messages: Membrane

7955:cep135
gene id: 7955:cep135
uniprot id: Q5RG45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP135/TSGA10 family.
messages: Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for cep250 at the centriole (By similarity).
messages: centriole

7955:tagln3b
gene id: 7955:tagln3b
uniprot id: Q6P697
names: Similarity
messages: Belongs to the calponin family.

7955:LOC100007686
gene id: 7955:LOC100007686
uniprot id: A0A8M1RII2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

7955:si:ch211-79l20.4
gene id: 7955:si:ch211-79l20.4
uniprot id: A0A0R4IAI1
uniprot id: A0A8M2B4B7
uniprot id: A0A8N7T781
names: Similarity
messages: Belongs to the vir family.

7955:slc15a4
gene id: 7955:slc15a4
uniprot id: A0A0R4ICA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

7955:cdk8
gene id: 7955:cdk8
uniprot id: A0A8M2B9W5
uniprot id: A8E4S2
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:si:dkey-102f14.5
gene id: 7955:si:dkey-102f14.5
uniprot id: A0A8M2B5N3
uniprot id: Q1LV04
names: Similarity
messages: Belongs to the PHAF1 family.

7955:si:dkey-242e21.4
gene id: 7955:si:dkey-242e21.4
uniprot id: P0DOC8
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: May be involved in photoreceptor outer segment disk morphogenesis (By similarity).
messages: Photoreceptor inner segment
messages: Results in the cardinal features of Bardet-Biedl syndrome, including defects to the ciliated Kupffer's vesicle, delayed retrograde melanosome transport and impaired visual behavior.
messages: Ubiquitously expressed during early development and in adult tissues including the eye, brain, heart and kidney (PubMed:27008867).

7955:mrpl16
gene id: 7955:mrpl16
uniprot id: B8JM36
uniprot id: Q5RJT5
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

7955:pimr54
gene id: 7955:pimr54
uniprot id: A0A8M9QIQ2
uniprot id: B0S7G0
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:atg4a
gene id: 7955:atg4a
uniprot id: Q4VBK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

7955:cul1b
gene id: 7955:cul1b
uniprot id: A0A8M9PTY1
uniprot id: Q802D4
names: Similarity
messages: Belongs to the cullin family.

7955:med16
gene id: 7955:med16
uniprot id: A0A2R8Q3Q1
uniprot id: E7F602
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 16 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

7955:elovl5
gene id: 7955:elovl5
uniprot id: Q8AX86
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL5 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: dendrite

7955:LOC100534694
gene id: 7955:LOC100534694
uniprot id: A0A8M3BAR2
names: Similarity
messages: Belongs to the apolipoprotein L family.

7955:itgb1b.1
gene id: 7955:itgb1b.1
uniprot id: B3DIV2
uniprot id: Q3YA99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

7955:crtc1a
gene id: 7955:crtc1a
uniprot id: A0A8M3AQ99
uniprot id: A0A8M3B0Q7
uniprot id: A0A8M9QPR2
uniprot id: Q05AL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TORC family.
messages: Cytoplasm
messages: Nucleus

7955:pcmtl
gene id: 7955:pcmtl
uniprot id: A0A8M2B570
uniprot id: F1QL05
uniprot id: Q6PBS7
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

7955:zgc:136908
gene id: 7955:zgc:136908
uniprot id: Q29RA2
names: Similarity
messages: Belongs to the AAA ATPase family.

7955:il1rapl1b
gene id: 7955:il1rapl1b
uniprot id: B6ZK77
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the interleukin-1 receptor family.
messages: Cell membrane
messages: Cytoplasm
messages: Detectable at 24 hpf and gradually increases through development. Detected in the nervous system in olfactory placode, olfactory bulb, telencephalon and tectum.
messages: May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. During presynaptic differentiation may regulate both synaptic vesicle accumulation in axon terminals and subsequent axon terminal remodeling.
messages: The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.

7955:si:ch211-283h6.4
gene id: 7955:si:ch211-283h6.4
uniprot id: A3KQ58
names: Similarity
messages: Belongs to the UPF0561 family.

7955:sema3c
gene id: 7955:sema3c
uniprot id: A0A8M6Z658
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:taz
gene id: 7955:taz
uniprot id: A0A8M3AV28
uniprot id: A0A8M9PEW5
uniprot id: F1QCP6
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acyltransferase required to remodel newly synthesized phospholipid cardiolipin (1',3'-bis-[1,2-diacyl-sn-glycero-3-phospho]-glycerol or CL), a key component of the mitochondrial inner membrane, with tissue specific acyl chains necessary for adequate mitochondrial function (By similarity). Its role in cellular physiology is to improve mitochondrial performance (By similarity). CL is critical for the coassembly of lipids and proteins in mitochondrial membranes, for instance, remodeling of the acyl groups of CL in the mitochondrial inner membrane affects the assembly and stability of respiratory chain complex IV and its supercomplex forms (By similarity). Catalyzes the transacylation between phospholipids and lysophospholipids, with the highest rate being between phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) and CL. Catalyzes both 1-acyl-sn-glycero-3-phosphocholine (lysophosphatidylcholine or LPC) reacylation and PC-CL transacylation, that means, it exchanges acyl groups between CL and PC by a combination of forward and reverse transacylations. Also catalyzes transacylations between other phospholipids such as phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) and CL, between PC and PE, and between PC and phosphatidate (1,2-diacyl-sn-glycero-3-phosphate or PA), although at lower rate. Not regiospecific, it transfers acyl groups into any of the sn-1 and sn-2 positions of the monolysocardiolipin (MLCL), which is an important prerequisite for uniformity and symmetry in CL acyl distribution. Cannot transacylate dilysocardiolipin (DLCL), thus, the role of MLCL is limited to that of an acyl acceptor. CoA-independent, it can reshuffle molecular species within a single phospholipid class. Redistributes fatty acids between MLCL, CL, and other lipids, which prolongs the half-life of CL. Its action is completely reversible, which allows for cyclic changes, such as fission and fusion or bending and flattening of the membrane. Hence, b…
messages: At 10 hours post-fertilization (hpf), expressed ubiquitously, including in cardiac progenitor regions, with strongest expression in the head area. By 24 hpf, highly expressed in the head, eyes, and tail. By 30 hpf, expression is restricted to the head, heart, eyes, and the region next to the yolk corresponding to endodermal tissue. At 51 hpf, expression is restricted to the heart.
messages: Before gastrulation, expression is barely detectable. At 7 hours post-fertilization (hpf), sharply up-regulated. High-level expression continues throughout the segmentation (12 hpf) and pharyngula (24 to 30 hpf) stages. At hatching at 51 hpf, expression declines dramatically.
messages: Belongs to the taffazin family.
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane
messages: Morpholino knockdown results in dose-dependent lethality, severe developmental and growth retardation, marked bradycardia and pericardial effusions, and generalized edema.
messages: The HXXXXD motif is essential for acyltransferase activity.
messages: The enzyme was named after a masochistic character Tafazzi, once popular on Italian television, apparently due to the difficulty encountered for its identification and characterization.

7955:gbf1
gene id: 7955:gbf1
uniprot id: A0A286Y9X1
uniprot id: A0A8M3AYV9
uniprot id: A0A8M3B513
uniprot id: A0A8M3BEH1
names: Subcellular Location Annotation
messages: Golgi apparatus

7955:il13ra2
gene id: 7955:il13ra2
uniprot id: A8WH77
names: Subcellular Location Annotation
messages: Membrane

7955:cdkn2aip
gene id: 7955:cdkn2aip
uniprot id: A0A8M2BGC0
uniprot id: A0A8M2BGE3
uniprot id: A0A8M2BGF0
uniprot id: F1QZX8
uniprot id: Q5XJR4
names: Similarity
messages: Belongs to the CARF family.

7955:pcsk5b
gene id: 7955:pcsk5b
uniprot id: Q069L0
names: Similarity
messages: Belongs to the peptidase S8 family.

7955:cadm4
gene id: 7955:cadm4
uniprot id: A0A8M2B4F3
uniprot id: A0A8M2B4X9
uniprot id: B0CLV3
uniprot id: Q5U3R8
names: Similarity
messages: Belongs to the nectin family.

7955:arxa
gene id: 7955:arxa
uniprot id: B3DKI9
uniprot id: O42115
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Expressed at 10 hours and 12 hours in presumptive diencephalon. Expressed transiently at 12 hours in caudal telencephalon. Later expression in floor plate and somites, followed by rostral telencephalon and ventral thalamus. Expressed at 40 hours in hypothalamus.
messages: Expressed in brain.
messages: Nucleus
messages: Transcription factor (By similarity). Appears to be indispensable for the central nervous system development. May have a role in the neuronal differentiation of the ganglionic eminence and ventral thalamus. May also be involved in axonal guidance in the floor plate.

7955:LOC561083
gene id: 7955:LOC561083
uniprot id: A0A8M3AZ57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:esrp1
gene id: 7955:esrp1
uniprot id: A1L1G1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESRP family.
messages: Nucleus
messages: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity).

7955:pex5la
gene id: 7955:pex5la
uniprot id: A0A8M6Z6W4
uniprot id: A0A8M9PTJ1
uniprot id: A0A8M9Q0K3
uniprot id: A0A8M9Q4I7
names: Similarity
messages: Belongs to the peroxisomal targeting signal receptor family.

7955:pimr163
gene id: 7955:pimr163
uniprot id: A0A8M9PCZ2
uniprot id: A0A8M9PIM4
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.

7955:gabra5
gene id: 7955:gabra5
uniprot id: E9QE70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:tyro3
gene id: 7955:tyro3
uniprot id: B3DGN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cell membrane
messages: Membrane

7955:ppp6r3
gene id: 7955:ppp6r3
uniprot id: A0A286YB73
uniprot id: A0A8M3ANY4
uniprot id: A0A8M3APJ9
uniprot id: A0A8M3AWD3
uniprot id: A0A8M3AWD6
uniprot id: A0A8M3AZH6
uniprot id: A0A8M3B6Z8
uniprot id: A0A8M3B701
uniprot id: X1WG48
names: Similarity
messages: Belongs to the SAPS family.

7955:nmba
gene id: 7955:nmba
uniprot id: A0A8M2B675
uniprot id: Q1MT60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: Secreted

7955:tph1a
gene id: 7955:tph1a
uniprot id: A0A8M6YYD4
uniprot id: Q6PBX4
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

7955:ezh2
gene id: 7955:ezh2
uniprot id: Q08BS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.
messages: Component of the prc2/eed-ezh2 complex.
messages: Nucleus
messages: Polycomb group (PcG) protein. Catalytic subunit of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. May regulate the circadian clock via histone methylation at the promoter of the circadian genes.

7955:pnn
gene id: 7955:pnn
uniprot id: F1QT45
uniprot id: Q66HU9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pinin family.
messages: Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.
messages: Nucleus speckle
messages: desmosome

7955:urp2
gene id: 7955:urp2
uniprot id: Q199U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

7955:cep63
gene id: 7955:cep63
uniprot id: A0A8M9QF95
uniprot id: Q6PGZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP63 family.
messages: Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression.
messages: centriole
messages: centrosome

7955:trmt6
gene id: 7955:trmt6
uniprot id: Q32LR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM6/GCD10 family.
messages: Heterotetramer.
messages: Nucleus
messages: Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

7955:cux1a
gene id: 7955:cux1a
uniprot id: A0A2R8Q0A5
uniprot id: A0A2R8QFA5
uniprot id: A0A8M1RNM7
uniprot id: A0A8M2BJZ7
uniprot id: A0A8M9Q6L3
uniprot id: A0A8M9QCL4
uniprot id: E7F4J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

7955:prkg2
gene id: 7955:prkg2
uniprot id: A0A8M9Q2S7
uniprot id: A2AVJ3
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

7955:npc1
gene id: 7955:npc1
uniprot id: A0A0R4IZV0
uniprot id: A0A2R8Q2J0
uniprot id: F1QNG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

7955:mtnr1c
gene id: 7955:mtnr1c
uniprot id: A2BGT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity.
messages: Membrane

7955:tbx16
gene id: 7955:tbx16
uniprot id: O93389
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7955:dmgdh
gene id: 7955:dmgdh
uniprot id: A0A8M9PCV7
names: Similarity
messages: Belongs to the GcvT family.

7955:smcr8a
gene id: 7955:smcr8a
uniprot id: E7FA21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMCR8 family.
messages: Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity.
messages: Component of the C9orf72-SMCR8 complex. The C9orf72-SMCR8 complex associates with the ATG1/ULK1 kinase complex.
messages: Cytoplasm
messages: Nucleus

7955:tfap2c
gene id: 7955:tfap2c
uniprot id: A0A8M6YYQ6
uniprot id: A0A8M9PM23
uniprot id: A0A8M9PZP3
uniprot id: Q5PQZ4
names: Similarity
messages: Belongs to the AP-2 family.

7955:si:ch211-113a14.17
gene id: 7955:si:ch211-113a14.17
uniprot id: A3KPR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:acap1
gene id: 7955:acap1
uniprot id: A1L1F5
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

7955:susd5
gene id: 7955:susd5
uniprot id: A0A8M3ASV6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC100332761
gene id: 7955:LOC100332761
uniprot id: A0A8M6YWX7
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:hyal3
gene id: 7955:hyal3
uniprot id: A0A8M1NJV4
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

7955:pbrm1l
gene id: 7955:pbrm1l
uniprot id: A0A8M2BG23
uniprot id: E7EZ71
names: Subcellular Location Annotation
messages: Nucleus

7955:mtmr12
gene id: 7955:mtmr12
uniprot id: A0A0R4IW75
uniprot id: A2BGG1
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an adapter for the myotubularin phosphatase mtm1 to regulate mtm1 protein stability and possibly its intracellular location (PubMed:23818870). By stabilizing mtm1 protein levels, required for skeletal muscle maintenance but not for myogenesis (PubMed:23818870). In skeletal muscle cells, does not regulate mtm1 subcellular localization (PubMed:23818870).
messages: Although it belongs to the non-receptor class myotubularin subfamily, lacks the conserved active site cysteine residue at position 378 in the dsPTPase catalytic loop and does not have phosphatase activity.
messages: At 1 day post fertilization (dpf), expressed ubiquitously in developing eyes, brain, heart and skeletal muscles. Maternally expressed up to 8 hour post fertilization and zygotic expression starts at 1 dpf and continues until 5 dpf.
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Heterodimer with lipid phosphatase mtm1 (By similarity). In skeletal muscles, the interaction stabilizes both mtmr12 and mtm1 protein levels (PubMed:23818870).
messages: Morpholino knockdown results in early embryonic mortality between 3 to 5 days post fertilization. Causes a reduction in size with an abnormal dorsal curvature through the back and tail. Impaired motor function characterized by a delay in chorion hatching and a reduced motility. Some animals have pericardial edema. Defects in skeletal muscles including sarcomeric disorganization often with central nucleation and triad disorganization. In skeletal muscles, increased phosphatidylinositol 3-phosphate levels and severe reduction of mtm1 levels without affecting mtm1 subcellular localization. Double morpholino knockdown of mtmr12 and mtm1 results in a more severe phenotype.
messages: Sarcoplasmic reticulum
messages: sarcomere

7955:ora1
gene id: 7955:ora1
uniprot id: A0A0R4IM31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Highly expressed in the olfactory rosette where it localizes to a subset of olfactory sensory neurons, mainly in the apical region of the neuroepithelium. Not detected in other tissues tested.
messages: Probable pheromone receptor. Shows high specificity for 4-hydroxyphenylacetic acid. Activation of the receptor stimulates intracellular calcium release.

7955:si:ch211-107n13.1
gene id: 7955:si:ch211-107n13.1
uniprot id: Q1L8C9
names: Similarity
messages: Belongs to the FAM110 family.

7955:g2e3
gene id: 7955:g2e3
uniprot id: A0A8M9PKK8
uniprot id: Q8AW58
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:as3mt
gene id: 7955:as3mt
uniprot id: Q29R95
names: Similarity
messages: Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.

7955:palm1b
gene id: 7955:palm1b
uniprot id: A0A2R8RTM3
uniprot id: B0V0Y4
uniprot id: Q6PGZ2
names: Similarity
messages: Belongs to the paralemmin family.

7955:gng8
gene id: 7955:gng8
uniprot id: Q503Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

7955:kremen1
gene id: 7955:kremen1
uniprot id: A0A8M3ARY7
uniprot id: B0BLV6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:pih1d2
gene id: 7955:pih1d2
uniprot id: A0A8M3B0W4
uniprot id: A0A8M9Q0C7
uniprot id: A0A8M9QBZ8
uniprot id: A0A8M9QH82
uniprot id: Q5PRB3
names: Similarity
messages: Belongs to the PIH1 family.

7955:ndel1a
gene id: 7955:ndel1a
uniprot id: A0A8M3B4J0
uniprot id: A0A8M3B7C3
uniprot id: B2GPL0
uniprot id: Q7SXI6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudE family.
messages: Phosphorylated in mitosis.
messages: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end (By similarity).
messages: centrosome
messages: cytoskeleton
messages: spindle

7955:LOC100537594
gene id: 7955:LOC100537594
uniprot id: A0A8M9PVN0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:glceb
gene id: 7955:glceb
uniprot id: F1QR43
names: Activity Regulation
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-glucuronyl C5-epimerase family.
messages: Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains (PubMed:16156897, PubMed:25568314). Plays a role in dorso-ventral axis specification during early development, together with glcea, where it may potentiate signaling via the BMP pathway (PubMed:16156897).
messages: Detected from 0.5 to 48 hours post-fertilization (hpf) (PubMed:16156897). At 24-36 hpf, expressed in adaxial mesoderm, somites, notochord, floorplate, hypochord, tail bud, eye, telencephalon, diencephalon, midbrain, hindbrain and otic vesicle (PubMed:17195182).
messages: Double morpholino knockdown of both glcea and glceb results in dorsalized embryos, with reduced ventral tail fin, kinked tail and an enlarged heart cavity. In severe cases there is significant shortening of the body and tail coiling. Epimerase activity is reduced. Expression of the dorsalizing factor chordin is expanded, whereas expression of bmp2b is reduced, notably in the tail. Expression of gata1 in blood islets is also reduced.
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Inhibited by O-sulfated heparin, which is produced by a downstream step in the heparin biosynthesis pathway.
messages: It is uncertain whether Met-1 or Met-2 is the initiator.

7955:ptger4c
gene id: 7955:ptger4c
uniprot id: S6B1G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:mfsd11
gene id: 7955:mfsd11
uniprot id: A0A8M2BGE8
uniprot id: Q4V9F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

7955:ggact.3
gene id: 7955:ggact.3
uniprot id: A0A8M2BFL9
uniprot id: A3KNL6
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine.
messages: May contribute to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine.

7955:zgc:171695
gene id: 7955:zgc:171695
uniprot id: A0A8M1NFV0
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:LOC103908963
gene id: 7955:LOC103908963
uniprot id: A0A8M9NZF4
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

7955:cacna1e
gene id: 7955:cacna1e
uniprot id: A0A8M6YZX9
uniprot id: A0A8M6Z7T0
uniprot id: A0A8M6Z865
uniprot id: A0A8M9PR96
uniprot id: A0A8M9Q3S8
uniprot id: A0A8M9QE19
uniprot id: A0A8M9QIU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane

7955:crygm2d20
gene id: 7955:crygm2d20
uniprot id: A3KNR6
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:mfsd9
gene id: 7955:mfsd9
uniprot id: A0A8M1QKK6
names: Subcellular Location Annotation
messages: Membrane

7955:isl2a
gene id: 7955:isl2a
uniprot id: A0A8M2BA75
uniprot id: A0A8M9PGP9
uniprot id: A0A8M9PML2
uniprot id: B3DH43
uniprot id: P53406
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in subtype specialization of primary motoneurons.
messages: First expressed at 15 hours post-fertilization (hpf), segmentally in the ventral region of the spinal cord (primary motoneurons) and then later in the dorsal regions (Rohan-Beard neurons). At 18 hpf, also expressed in tail bud and pronephric duct. At 24 hpf, expressed strongly in trigeminal ganglia. At 30 hpf, expressed transiently in pectoral fin bud.
messages: Nucleus

7955:si:ch1073-145m9.1
gene id: 7955:si:ch1073-145m9.1
uniprot id: X1WFD8
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

7955:cxcl8a
gene id: 7955:cxcl8a
uniprot id: A0A0G2KYH9
uniprot id: A0A8M3B7M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

7955:lim2.1
gene id: 7955:lim2.1
uniprot id: Q503X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

7955:csnk1db
gene id: 7955:csnk1db
uniprot id: Q6P3K7
names: Activity Regulation
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated on serine and threonine residues.
messages: Belongs to the protein kinase superfamily.
messages: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating per1 and per2, which may lead to their degradation. Participates in wnt signaling (By similarity).
messages: Cytoplasm
messages: Exhibits substrate-dependent heparin activation.
messages: Monomer (By similarity). Interacts with per1 and per2. Component of the circadian core oscillator (By similarity).
messages: Nucleus
messages: Ubiquitously expressed in embryos until eight hours after fertilization. Highly expressed in the developing neural plate eight hours after fertilization. Detected in telencephalon, retina, diencephalon, mesencephalon, cerebellum and rhombomeres between 24 and 38 hours after fertilization. Detected in tegmentum, myencephalon and notochord 48 hours after fertilization.

7955:zmp:0000000660
gene id: 7955:zmp:0000000660
uniprot id: E7F7Y0
names: Subcellular Location Annotation
messages: Cytoplasm

7955:si:dkey-239j18.3
gene id: 7955:si:dkey-239j18.3
uniprot id: E7F8Y7
names: Similarity
messages: Belongs to the peptidase C1 family.

7955:ppp1r14ab
gene id: 7955:ppp1r14ab
uniprot id: A0A8M9QLB3
uniprot id: Q6PBJ4
names: Similarity
messages: Belongs to the PP1 inhibitor family.

7955:LOC563017
gene id: 7955:LOC563017
uniprot id: A0A8M9PPX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

7955:cers5
gene id: 7955:cers5
uniprot id: A0A8M9PDT3
uniprot id: Q7T3F1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

7955:lrp2a
gene id: 7955:lrp2a
uniprot id: E0AE56
names: Caution
names: Similarity
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:stx11b.2
gene id: 7955:stx11b.2
uniprot id: A8E5D3
names: Similarity
messages: Belongs to the syntaxin family.

7955:si:dkey-85p17.3
gene id: 7955:si:dkey-85p17.3
uniprot id: E7EXR8
names: Subcellular Location Annotation
messages: cytoskeleton

7955:mtmr2
gene id: 7955:mtmr2
uniprot id: A0JMK5
uniprot id: B2GSD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Early endosome membrane
messages: Homooligomer and heterooligomer.
messages: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (By similarity).

7955:tldc1
gene id: 7955:tldc1
uniprot id: Q1LWV7
names: Function
names: Subcellular Location Annotation
messages: Activates an alternative mTOR signaling to regulate cell proliferation and migration.
messages: Cytoplasm
messages: Lysosome
messages: Membrane

7955:rab39bb
gene id: 7955:rab39bb
uniprot id: A1A5H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

7955:celf4
gene id: 7955:celf4
uniprot id: A0A8M3ALA7
uniprot id: A0A8M3ATP3
uniprot id: A0A8M3AWN6
uniprot id: A0A8M3B4J4
uniprot id: A0A8M6Z3M4
uniprot id: A0A8M9P396
uniprot id: A0A8M9PCL3
uniprot id: A0A8M9PQD3
uniprot id: A0A8M9PTS7
uniprot id: Q6DGV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus
messages: RNA-binding protein that may be implicated in the regulation of pre-mRNA alternative splicing.

7955:mxd3
gene id: 7955:mxd3
uniprot id: Q7SX95
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (By similarity).
messages: Nucleus
messages: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3' (By similarity).

7955:mhc1zda
gene id: 7955:mhc1zda
uniprot id: A0A8M2BI98
uniprot id: A0A8M9QF35
uniprot id: U6BMG4
names: Similarity
messages: Belongs to the MHC class I family.

7955:heatr1
gene id: 7955:heatr1
uniprot id: A0A8M3B4F6
uniprot id: Q7SY48
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Abnormalities in the brain starting at midsomitogenesis stages.
messages: Belongs to the HEATR1/UTP10 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Required for cell survival in the CNS through its role in rRNA synthesis and processing.
messages: nucleolus

7955:adra1bb
gene id: 7955:adra1bb
uniprot id: Q5U3D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:slc22a7b.3
gene id: 7955:slc22a7b.3
uniprot id: F1QS93
names: Subcellular Location Annotation
messages: Membrane

7955:tmem35
gene id: 7955:tmem35
uniprot id: F1QZJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

7955:si:dkey-194e6.1
gene id: 7955:si:dkey-194e6.1
uniprot id: A0A8M9PWE5
uniprot id: F1QQZ6
uniprot id: Q1JPS7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:ube2ib
gene id: 7955:ube2ib
uniprot id: Q9W6H5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis.
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Forms a tight complex with rangap1 and ranbp2 (By similarity). Interacts with vsx1.
messages: Nucleus

7955:gnal
gene id: 7955:gnal
uniprot id: Q5U3H6
names: Similarity
messages: Belongs to the G-alpha family. G(s) subfamily.

7955:dap1b
gene id: 7955:dap1b
uniprot id: Q9I9N0
names: Function
names: Similarity
names: Subunit
messages: Associates with ribosomes; preventing translation (PubMed:36653451). Interacts with eiF5a (eif5a and eif5a2); preventing translation (PubMed:36653451).
messages: Belongs to the DAP-DAPL1 family.
messages: Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36653451). Acts via its association with eiF5a (eif5a and eif5a2) at the polypeptide exit tunnel of the ribosome, preventing mRNA translation (PubMed:36653451). Plays a key role in ribosome hibernation in the mature egg by preventing mRNA translation, leading to ribosome inactivation (PubMed:36653451). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the egg and early embryo (PubMed:36653451).

7955:brpf3b
gene id: 7955:brpf3b
uniprot id: F6P390
names: Subcellular Location Annotation
messages: Nucleus

7955:mapre1b
gene id: 7955:mapre1b
uniprot id: A0A8M2B926
uniprot id: Q6NUY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

7955:ran
gene id: 7955:ran
uniprot id: P79735
uniprot id: Q6GTE7
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Ran family.
messages: Cytoplasm
messages: Expression is low at 2 hpf and starts to increase steadily after 12 hpf to reach adult levels at 72 hpf.
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
messages: GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis.
messages: Mg(2+) interacts primarily with the phosphate groups of the bound guanine nucleotide.
messages: Monomer. Interacts with rangap1, which promotes ran-mediated GTP hydrolysis. Interacts with kpnb1. Interaction with kpnb1 inhibits rangap1-mediated stimulation of GTPase activity. Interacts with rcc1 which promotes the exchange of ran-bound GDP by GTP. Interaction with kpnb1 inhibits rcc1-mediated exchange of ran-bound GDP by GTP. Interacts (GTP-bound form) with tnpo1; the interaction is direct. Interacts (GTP-bound form) with tnpo3; the interaction is direct. Interacts with kpnb1 and with tnpo1; both inhibit ran GTPase activity. Interacts (via C-terminus) with ranbp1, which alleviates the inhibition of ran GTPase activity. Interacts with rangrf, which promotes the release of bound guanine nucleotide. Rangrf and rcc1 compete for an overlapping binding site on ran. Identified in a complex with kpna2 and cse1l; interaction with ranbp1 mediates dissociation of ran from this complex. Interaction with both ranbp1 and kpna2 promotes dissociation of the complex between ran and kpnb1. Identified in a complex composed of ran, rangap1 and ranbp1. Identified in a complex that contains tnpo1, ran and ranbp1. Identified in a nuclear export complex with xpo1. Interaction with ranbp1 or ranbp2 induces a conformation change in the complex formed by xpo1 and ran that triggers the release of the nuclear export signal of cargo proteins. Component of a nuclear export receptor complex composed of kpnb1, ran, snupn and xpo1 (By similarity).
messages: Nucleus
messages: Nucleus envelope
messages: Ubiquitous, with the highest expression in ovary, muscle, eye and brain.
messages: cytosol

7955:sox3
gene id: 7955:sox3
uniprot id: A9JSZ3
uniprot id: Q6EJB7
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Expressed both maternally and zygotically. Maternal expression is weak and zygotic expression is strong by the 30% epiboly stage. At the gastrula stage, expressed in all prospective neural tissue with the exception of a band of cells in the prospective midbrain and hindbrain. At the tail bud to 3-somite stage, expressed in distinct regions of the future brain, the anterior margin of the neural plate and the primordia of the epibranchial placodes. At the 12-somite stage, broad expression in the central nervous system (CNS), with weakest expression at the forebrain-midbrain and midbrain-hindbrain boundaries and in the posterior CNS. At the 21- to 25-somite stage, broad expression in the CNS and the lens.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcriptional activator.

7955:prrx1b
gene id: 7955:prrx1b
uniprot id: A0A8M2B7I0
uniprot id: A0A8M6YUR5
uniprot id: Q6P295
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

7955:exd1
gene id: 7955:exd1
uniprot id: Q0P3U3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EXD1 family.
messages: Cytoplasm
messages: Homodimer (By similarity). Component of the PET complex (By similarity).
messages: RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity. The PET complex is required during the secondary piRNAs metabolic process for the piwil2 slicing-triggered loading of piwil4 piRNAs. In the PET complex, exd1 probably acts as an RNA adapter. Exd1 is an inactive exonuclease.
messages: The 3'-5' exonuclease domain lacks the conserved Asp-Glu-Asp-Asp (DEDD) residues that coordinates divalent ions essential for exonuclease activity.

7955:edn3
gene id: 7955:edn3
uniprot id: A0A8M2B1S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

7955:ptges3b
gene id: 7955:ptges3b
uniprot id: Q6IQI3
names: Similarity
messages: Belongs to the p23/wos2 family.

7955:nxt2
gene id: 7955:nxt2
uniprot id: E9QCN6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

7955:LOC100004321
gene id: 7955:LOC100004321
uniprot id: I3ITC2
names: Similarity
messages: Belongs to the Bcl-2 family.

7955:dbnla
gene id: 7955:dbnla
uniprot id: A0A8M3B6K6
uniprot id: Q6GMH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABP1 family.
messages: Early endosome
messages: Golgi apparatus membrane
messages: Perikaryon
messages: Postsynaptic density
messages: cell cortex
messages: clathrin-coated vesicle membrane
messages: dendrite
messages: lamellipodium
messages: neuron projection
messages: podosome
messages: ruffle

7955:si:dkey-239i20.2
gene id: 7955:si:dkey-239i20.2
uniprot id: Q5TZD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

7955:cyp2x9
gene id: 7955:cyp2x9
uniprot id: Q05AL5
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:crygs4
gene id: 7955:crygs4
uniprot id: Q5XTN2
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:top2a
gene id: 7955:top2a
uniprot id: A0A0R4IUF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
messages: nucleolus
messages: nucleoplasm

7955:b4galnt2.1
gene id: 7955:b4galnt2.1
uniprot id: F1R3L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Membrane

7955:cdk11b
gene id: 7955:cdk11b
uniprot id: A0A8M3AVM5
uniprot id: A0A8M3BC62
uniprot id: Q5PRD1
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

7955:crybb1l1
gene id: 7955:crybb1l1
uniprot id: E7F8M1
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:LOC101885436
gene id: 7955:LOC101885436
uniprot id: A0A8M6Z1G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:polr3gla
gene id: 7955:polr3gla
uniprot id: A0A0R4INA2
uniprot id: A0A8M1N2F0
uniprot id: Q66IE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

7955:ttll6
gene id: 7955:ttll6
uniprot id: A8CVX7
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin--tyrosine ligase family.
messages: Cytoplasm
messages: Fish display a lack of tubulin polyglutamylation and cilia formation in olfactory placodes.
messages: Gln-174 is the main determinant for regioselectivity, which segregates between initiases and elongases in all tubulin--tyrosine ligase family. A glutamine residue at this position is found in elongases TTLL6, TTLL9, TTLL11, TTLL13, TTLL10 and favors glutamate-chain elongation, whereas an arginine residue is found in initiases TTLL2, TTLL4, TTLL5, TTLL3, TTLL8 and favors initiation.
messages: Polyglutamylase which modifies both tubulin and non-tubulin proteins, generating alpha-linked polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues of target proteins (By similarity). Preferentially mediates ATP-dependent long polyglutamate chain elongation over the initiation step of the polyglutamylation reaction (By similarity). Preferentially modifies the alpha-tubulin tail over a beta-tail (By similarity). Mediates microtubule polyglutamylation in cilia axoneme, which is important for ciliary structural formation and motility (PubMed:17761526, PubMed:22246503). Polyglutamylates olfactory cilia, necessary for the regulation of ciliary sructure and beating (PubMed:17761526).
messages: The flexible c-MTBD (cationic microtubule binding domain) region mediates binding to microtubules. It is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding.
messages: cilium axoneme
messages: cilium basal body
messages: cytoskeleton

7955:cntnap5l
gene id: 7955:cntnap5l
uniprot id: A0A8M6Z962
uniprot id: A0A8M9Q7S5
uniprot id: A0A8M9QDQ4
uniprot id: E7EZI3
names: Caution
names: Similarity
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC110439321
gene id: 7955:LOC110439321
uniprot id: A0A8M9Q5M8
names: Subcellular Location Annotation
messages: Membrane

7955:sned1
gene id: 7955:sned1
uniprot id: A0A8M3BAE4
uniprot id: E7F2S5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:morn5
gene id: 7955:morn5
uniprot id: Q4VBJ9
names: Subcellular Location Annotation
messages: flagellum

7955:vdra
gene id: 7955:vdra
uniprot id: Q9PTN2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Cytoplasm
messages: Detected in embryo 24 to 48 hours after fertilization and in gastrula.
messages: Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding (By similarity). Interacts with ncoa1 and possibly other coactivators, leading to a strong increase of transcription of target genes (PubMed:17218092, PubMed:17346665).
messages: Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

7955:ilkap
gene id: 7955:ilkap
uniprot id: A0A8M2B440
uniprot id: A0A8M2B4P4
uniprot id: E7EY20
names: Similarity
messages: Belongs to the PP2C family.

7955:si:dkey-193b15.8
gene id: 7955:si:dkey-193b15.8
uniprot id: B0S6B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

7955:kcnj5
gene id: 7955:kcnj5
uniprot id: A0A0R4IAD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

7955:prc1a
gene id: 7955:prc1a
uniprot id: A0A0R4IC50
uniprot id: A0A8M9PY83
uniprot id: Q6DI02
names: Similarity
messages: Belongs to the MAP65/ASE1 family.

7955:pcmtd1
gene id: 7955:pcmtd1
uniprot id: Q32PW8
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

7955:slc44a5b
gene id: 7955:slc44a5b
uniprot id: A0A286Y805
uniprot id: A0A8M3AV02
uniprot id: A0A8M3B1V7
uniprot id: A0A8M3B4S2
uniprot id: A0A8M9Q3G7
uniprot id: G1K2Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

7955:oprm1
gene id: 7955:oprm1
uniprot id: B8JHS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Endosome
messages: Membrane
messages: Perikaryon
messages: axon
messages: dendrite

7955:mrps14
gene id: 7955:mrps14
uniprot id: Q0P3Z3
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

7955:smpd4
gene id: 7955:smpd4
uniprot id: Q6PFJ7
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, and endoplasmic reticulum organization and function. May sensitize cells to DNA damage-induced apoptosis.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Nucleus envelope
messages: sarcolemma

7955:slc1a1
gene id: 7955:slc1a1
uniprot id: A0A8M9QGS6
uniprot id: D7RVR6
uniprot id: Q6DG02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

7955:mov10b.1
gene id: 7955:mov10b.1
uniprot id: Q1LXK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
messages: P-body
messages: Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (By similarity).

7955:mks1
gene id: 7955:mks1
uniprot id: A3QK09
names: Subcellular Location Annotation
messages: cilium basal body

7955:olfm1b
gene id: 7955:olfm1b
uniprot id: B7ZD15
uniprot id: B7ZD17
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

7955:inpp4aa
gene id: 7955:inpp4aa
uniprot id: A0A2R8QEX9
uniprot id: B0S737
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

7955:kdm7ab
gene id: 7955:kdm7ab
uniprot id: A0A8M1P2J3
uniprot id: F1QHF6
names: Similarity
messages: Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.

7955:gabrb3
gene id: 7955:gabrb3
uniprot id: A0A0R4ILP2
uniprot id: A0A8M2BDH7
uniprot id: A0A8M9PYR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:atp5h
gene id: 7955:atp5h
uniprot id: Q6PC77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase d subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

7955:zap70
gene id: 7955:zap70
uniprot id: Q503P3
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.

7955:pcyt2
gene id: 7955:pcyt2
uniprot id: Q5XJC6
names: Similarity
messages: Belongs to the cytidylyltransferase family.

7955:rorc
gene id: 7955:rorc
uniprot id: A0A8M1PV85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

7955:LOC100006975
gene id: 7955:LOC100006975
uniprot id: A0A8M9PS28
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.

7955:zhx2a
gene id: 7955:zhx2a
uniprot id: A5D8R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

7955:si:ch73-272h16.4
gene id: 7955:si:ch73-272h16.4
uniprot id: A0A8M3AT59
uniprot id: A0A8M6Z158
uniprot id: A0A8M9PMH0
uniprot id: A0A8M9QAP3
names: Similarity
messages: Belongs to the MAGUK family.

7955:c7a
gene id: 7955:c7a
uniprot id: A0A8M3AV96
uniprot id: A0A8N7UT40
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:rplp2l
gene id: 7955:rplp2l
uniprot id: A7E2K4
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

7955:hsd17b12b
gene id: 7955:hsd17b12b
uniprot id: A7MCK2
uniprot id: Q6QA33
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
messages: Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.
messages: Endoplasmic reticulum membrane
messages: Expressed throughout development. Weakly or not expressed in some adult organs.

7955:tmem218
gene id: 7955:tmem218
uniprot id: A0A8M9Q5T2
uniprot id: Q7SZ56
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM218 family.
messages: May be involved in ciliary biogenesis or function.
messages: Membrane
messages: Morpholino knockdown leads to the formation of pronephric cysts and hydrocephalus, features consistent with a ciliopathy.
messages: cilium

7955:rbm48
gene id: 7955:rbm48
uniprot id: Z4YHP6
names: Function
names: Similarity
messages: As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
messages: Belongs to the RBM48 family.

7955:sgk1
gene id: 7955:sgk1
uniprot id: A0A8M2B972
uniprot id: A0A8M2B9J1
uniprot id: Q7ZTW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Nucleus
messages: Protein kinase that may play an important role in cellular stress response. May be involved in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion (By similarity).

7955:zgc:113364
gene id: 7955:zgc:113364
uniprot id: A0A8M3AP29
uniprot id: A0A8M3B091
uniprot id: A0A8M9PZ69
uniprot id: Q56A34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: nucleoplasm

7955:ch25hl1.2
gene id: 7955:ch25hl1.2
uniprot id: Q1LX59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family.
messages: Endoplasmic reticulum membrane
messages: May catalyze the formation of 25-hydroxycholesterol from cholesterol.

7955:marcksl1b
gene id: 7955:marcksl1b
uniprot id: Q6NWH2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the MARCKS family.
messages: Cell membrane
messages: Detected from 24 to 72 hours post-fertilization (hpf).
messages: Involved in the control of cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation.
messages: Morpholino knockdown of the protein results in reduced head and eye size, a ventrally curved body, and enlarged brain vesicles. In the craniofacial cartilage, the ceratobranchial arches are reduced. Formation of ceratohyal cartilage is disrupted with an abnormal angle relative to wild-type. Morphogenesis of the developing neural tube is abnormal, with a smaller angle between the walls of the hindbrain neuroepithelium at 24 hours post-fertilization (hpf) and in some cases a partial opening in the dorsal region. Some deformation of the midbrain walls is also found. Retinal development is significantly delayed; no retinal ganglion cells (RGCs) are detected at 30 hpf and reduced numbers are found at 60 hpf. RGCs also appear to be mislocalized. In about a third of embryos, three instead of two otoliths are detected in the inner ear. Cilium length in Kupffer's vesicle is significantly reduced. Cilia in the olfactory placode also appear to be fewer in number and have reduced length. Double morpholino knockdown of marcksl1a and marckls1b results in a more pronounced developmental delay in the retina. Double morpholino knockdown of marcksb and marcksl1b results in retinal morphogenesis defects of increased severity. The optic cup structure is not apparent, and very few atoh7-positive retinal ganglion cell precursors are detected. Double morpholino knockdown of marcksb and marcksl1b also results in more severe defects in neural tube morphology, with partial duplications of the neural tube in the hindbrain region.
messages: Strongly expressed in brain and eye. Also detected at lower levels in muscle.
messages: cytoskeleton

7955:pprc1
gene id: 7955:pprc1
uniprot id: E7F4W0
names: Subcellular Location Annotation
messages: Nucleus

7955:nrn1a
gene id: 7955:nrn1a
uniprot id: Q6DGP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuritin family.
messages: Cell membrane
messages: Modulates postsynaptic dendritic arbor elaboration and synaptic maturation.
messages: Synapse

7955:LOC101884556
gene id: 7955:LOC101884556
uniprot id: A0A8M2BLS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

7955:clta
gene id: 7955:clta
uniprot id: E7F1Q8
uniprot id: E9QDE6
uniprot id: Q6P937
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

7955:slc20a1b
gene id: 7955:slc20a1b
uniprot id: F1QI67
uniprot id: Q6PFM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.
messages: Sodium-phosphate symporter.

7955:stc1l
gene id: 7955:stc1l
uniprot id: Q6PHV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.
messages: Its primary function is the prevention of hypercalcemia. Upon release into the circulation, it lowers calcium transport by the gills, thereby reducing its rate of influx from the environment into the extracellular compartment. STC also stimulates phosphate reabsorption by renal proximal tubules. The consequence of this action is increased levels of plasma phosphate, which combines with excess calcium and promotes its disposal into bone and scales.

7955:gsr
gene id: 7955:gsr
uniprot id: A0A8M6Z2M1
uniprot id: A0A8M9QB21
uniprot id: Q503Y5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Maintains high levels of reduced glutathione in the cytosol.

7955:si:zfos-1505d6.3
gene id: 7955:si:zfos-1505d6.3
uniprot id: F1QNI8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:march2
gene id: 7955:march2
uniprot id: Q1LVZ2
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Lysosome membrane
messages: The RING-CH-type zinc finger domain is required for E3 ligase activity.

7955:purg
gene id: 7955:purg
uniprot id: A0A8M9QC97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

7955:parpbp
gene id: 7955:parpbp
uniprot id: J9JI04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PARI family.
messages: Cytoplasm
messages: Nucleus

7955:uck2b
gene id: 7955:uck2b
uniprot id: B2GQQ9
uniprot id: Q7ZV79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the uridine kinase family.
messages: Homotetramer.
messages: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor.

7955:pde4ba
gene id: 7955:pde4ba
uniprot id: A0A8M2BD66
uniprot id: A0A8M9PMW2
uniprot id: A0A8M9PYP3
uniprot id: A0A8M9Q0L5
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

7955:tmem19
gene id: 7955:tmem19
uniprot id: Q6IQ88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

7955:si:dkey-57a22.15
gene id: 7955:si:dkey-57a22.15
uniprot id: B0UYP0
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:tpm1
gene id: 7955:tpm1
uniprot id: A0A1L6UW63
uniprot id: A0A2R8RQ88
uniprot id: A0A8M2BLL0
uniprot id: A0A8M2BLM4
uniprot id: A0A8M2BLW8
uniprot id: A0A8M2BLW9
uniprot id: A0A8M3APV7
uniprot id: A0A8M3AZU4
uniprot id: A0A8M6Z4C1
uniprot id: A0A8M9P6D8
uniprot id: A0A8M9PUV7
uniprot id: A0A8M9PYA8
uniprot id: A7E2K1
uniprot id: Q6NYQ0
uniprot id: Q7ZVK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

7955:stx4
gene id: 7955:stx4
uniprot id: Q7ZV18
names: Similarity
messages: Belongs to the syntaxin family.

7955:si:ch211-126g16.10
gene id: 7955:si:ch211-126g16.10
uniprot id: B0UXE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:cavin2a
gene id: 7955:cavin2a
uniprot id: F1Q688
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

7955:hdac8
gene id: 7955:hdac8
uniprot id: A0A8M2BE34
uniprot id: Q7SXM0
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 1 subfamily.
messages: Binds 1 divalent metal cation per subunit.
messages: Chromosome
messages: Cytoplasm
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of non-histone proteins. In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones.
messages: Its activity is inhibited by trichostatin A (TSA) and butyrate, 2 well known histone deacetylase inhibitors.
messages: Nucleus

7955:kcnk2a
gene id: 7955:kcnk2a
uniprot id: F1QAI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

7955:rbp1
gene id: 7955:rbp1
uniprot id: B0R174
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

7955:sap18
gene id: 7955:sap18
uniprot id: Q6PC41
names: Function
names: Similarity
messages: Belongs to the SAP18 family.
messages: Involved in the tethering of the SIN3 complex to core histone proteins.

7955:tmprss3a
gene id: 7955:tmprss3a
uniprot id: A0A8M9QK25
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:runx3
gene id: 7955:runx3
uniprot id: Q9DEA0
names: Subcellular Location Annotation
messages: Nucleus

7955:hsp90b1
gene id: 7955:hsp90b1
uniprot id: Q7T3L3
names: Similarity
messages: Belongs to the heat shock protein 90 family.

7955:chrna2a
gene id: 7955:chrna2a
uniprot id: Q1RLX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:ppp4r3b
gene id: 7955:ppp4r3b
uniprot id: Q6P100
names: Similarity
messages: Belongs to the SMEK family.

7955:mical3b
gene id: 7955:mical3b
uniprot id: A0A8M3ARC5
uniprot id: A0A8M3AYP9
uniprot id: A0A8M9PHR6
uniprot id: A0A8M9PV05
uniprot id: A0A8M9Q0Z6
uniprot id: A0A8M9Q100
uniprot id: A0A8M9Q689
uniprot id: A0A8M9QBR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mical family.
messages: Cytoplasm

7955:si:dkey-245f22.3
gene id: 7955:si:dkey-245f22.3
uniprot id: Q7SZX7
names: Similarity
messages: Belongs to the MDFI family.

7955:rexo4
gene id: 7955:rexo4
uniprot id: F1QJP9
names: Similarity
messages: Belongs to the REXO4 family.

7955:jmy
gene id: 7955:jmy
uniprot id: Q6NVC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics.
messages: Belongs to the JMY family.
messages: Cytoplasmic vesicle
messages: Endomembrane system
messages: Nucleus
messages: autophagosome membrane
messages: cytoskeleton

7955:LOC101885386
gene id: 7955:LOC101885386
uniprot id: A0A8M9QHZ7
names: Similarity
messages: Belongs to the PROTOR family.

7955:gstz1
gene id: 7955:gstz1
uniprot id: Q6DGL3
uniprot id: X1WBU0
uniprot id: X1WD04
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

7955:unc45b
gene id: 7955:unc45b
uniprot id: Q6DGE9
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A band
messages: Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain (By similarity). Plays a role in sarcomere formation during muscle cell development. Required for myoseptal integrity, myofiber attachment, motility and craniofacial development (PubMed:17189627, PubMed:17586488, PubMed:20440001, PubMed:20849610). Is necessary for normal early lens development (PubMed:24549050).
messages: Expressed in striated muscle tissue including somites, heart and craniofacial muscle. Detected in mesoderm adjacent to the dorsal midline during the late gastrula stages and in somitic mesoderm during development of trunk skeletal muscle. Also expressed in cranial skeletal muscle and in cardiac and smooth muscle. Detected in somitic muscle and heart primordium of 24 hour embryos. At later stages, expressed in muscles of pectoral fins, jaw, branchial arches and eye.
messages: First detected at the late gastrula stages around 9 hours post-fertilization (hpf). Expression intensifies by the end of gastrulation around 10 hpf, continues into early somitogenesis stages around 12 hpf and persists in the somites until 96 hpf when the somites give rise to the trunk skeletal muscle.
messages: Interacts with apobec2a, apobec2b, hsp90a.1, hsp90a.2, hsp90ab1 and myosin.
messages: Z line
messages: perinuclear region

7955:parietopsin
gene id: 7955:parietopsin
uniprot id: F1QYR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

7955:LOC110440145
gene id: 7955:LOC110440145
uniprot id: A0A8M9QMZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.
messages: Membrane

7955:cep70
gene id: 7955:cep70
uniprot id: A0A8M6Z3B7
uniprot id: A0A8M9P470
uniprot id: A0A8M9PDS2
uniprot id: A8WFT5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.
messages: Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
messages: centrosome

7955:arcn1b
gene id: 7955:arcn1b
uniprot id: Q7ZU89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

7955:letm2
gene id: 7955:letm2
uniprot id: F1QSQ8
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane

7955:med6
gene id: 7955:med6
uniprot id: Q6IQ63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

7955:cxcl8b.1
gene id: 7955:cxcl8b.1
uniprot id: N0GW19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

7955:otop2
gene id: 7955:otop2
uniprot id: A0A8M1PS88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

7955:LOC100005096
gene id: 7955:LOC100005096
uniprot id: A0A8M1PZS3
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:slc1a6
gene id: 7955:slc1a6
uniprot id: A0A8M3AXC7
uniprot id: A7MC06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

7955:lmln
gene id: 7955:lmln
uniprot id: F1Q5N1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M8 family.
messages: Binds 1 zinc ion per subunit.

7955:nat8l
gene id: 7955:nat8l
uniprot id: A4IGD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the camello family.
messages: Catalyzes the synthesis of N-acetylaspartate acid (NAA) from L-aspartate and acetyl-CoA.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: Mitochondrion membrane

7955:plk2a
gene id: 7955:plk2a
uniprot id: A0A8M1RNL4
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

7955:itgb2
gene id: 7955:itgb2
uniprot id: E7FCN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

7955:si:dkey-108k21.26
gene id: 7955:si:dkey-108k21.26
uniprot id: E7F5W3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:LOC103911725
gene id: 7955:LOC103911725
uniprot id: A0A8M6Z1C5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MoaE family. MOCS2B subfamily.
messages: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
messages: This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2A).
messages: cytosol

7955:pnp4b
gene id: 7955:pnp4b
uniprot id: Q6P016
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

7955:htt
gene id: 7955:htt
uniprot id: A0A8M2B6V6
uniprot id: A0A8M3AIT6
uniprot id: A0A8M3AIU2
uniprot id: A0A8M3AU50
uniprot id: A0A8M3B295
uniprot id: O42269
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the huntingtin family.
messages: Cytoplasm
messages: May play a role in microtubule-mediated transport or vesicle function.
messages: Nucleus

7955:grn2
gene id: 7955:grn2
uniprot id: Q502S6
uniprot id: Q90ZC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the granulin family.
messages: Secreted

7955:slc25a24l
gene id: 7955:slc25a24l
uniprot id: A0A8M9PZP9
uniprot id: Q6DRB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

7955:xkr9
gene id: 7955:xkr9
uniprot id: B3DGC8
uniprot id: Q5GH36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

7955:trappc11
gene id: 7955:trappc11
uniprot id: Q1RLX4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPPC11 family.
messages: Component of the multisubunit TRAPP (transport protein particle) complex.
messages: Golgi apparatus
messages: Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.
messages: Pronounced hepatomegaly accompanied by lipid accumulation in the liver.
messages: cis-Golgi network

7955:tmem106c
gene id: 7955:tmem106c
uniprot id: Q08BL5
names: Similarity
messages: Belongs to the TMEM106 family.

7955:fam151b
gene id: 7955:fam151b
uniprot id: A0A8M3ASG4
uniprot id: A0A8M3B9M4
uniprot id: A2BGP8
uniprot id: A2BGP9
uniprot id: Q6DC01
names: Similarity
messages: Belongs to the FAM151 family.

7955:dag1
gene id: 7955:dag1
uniprot id: F1QMH7
uniprot id: Q8JHU7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.
messages: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
messages: cytoskeleton
messages: extracellular space
messages: nucleoplasm
messages: sarcolemma

7955:wasa
gene id: 7955:wasa
uniprot id: F1Q6U7
names: Subcellular Location Annotation
messages: Nucleus

7955:or118-1
gene id: 7955:or118-1
uniprot id: Q2PRD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:spaca4l
gene id: 7955:spaca4l
uniprot id: A0A2R8RYF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPACA4/bouncer family.
messages: Cell membrane
messages: Membrane

7955:or128-3
gene id: 7955:or128-3
uniprot id: Q2PRG2
names: Subcellular Location Annotation
messages: Membrane

7955:LOC101883783
gene id: 7955:LOC101883783
uniprot id: A0A8M9NZR8
uniprot id: A0A8M9PK54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

7955:sh3bp5a
gene id: 7955:sh3bp5a
uniprot id: A0A0G2L4V3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

7955:tspan37
gene id: 7955:tspan37
uniprot id: E9QH97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7955:zgc:103625
gene id: 7955:zgc:103625
uniprot id: Q66I74
names: Similarity
messages: Belongs to the UPF0585 family.

7955:slc6a18
gene id: 7955:slc6a18
uniprot id: A8WG91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:mrpl28
gene id: 7955:mrpl28
uniprot id: Q503Y2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

7955:olfm2b
gene id: 7955:olfm2b
uniprot id: A0A0R4ILX8
uniprot id: A0A8M9PSR8
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

7955:chsy3
gene id: 7955:chsy3
uniprot id: A4IG33
names: Subcellular Location Annotation
messages: Membrane

7955:LOC101882637
gene id: 7955:LOC101882637
uniprot id: A0A8M9PV20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:LOC103911956
gene id: 7955:LOC103911956
uniprot id: A0A8M6Z9F7
names: Similarity
messages: Belongs to the peptidase C13 family.

7955:ssu72
gene id: 7955:ssu72
uniprot id: Q6PC19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSU72 phosphatase family.
messages: Cytoplasm
messages: May be involved in the C-terminal domain of RNA polymerase II dephosphorylation, RNA processing and termination.
messages: Nucleus

7955:mylpfb
gene id: 7955:mylpfb
uniprot id: Q66I73
names: Subunit
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains.

7955:hspb8
gene id: 7955:hspb8
uniprot id: Q6PFS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Displays temperature-dependent chaperone activity.

7955:tprb
gene id: 7955:tprb
uniprot id: A0A8M3ATA7
uniprot id: Q5RI09
names: Similarity
messages: Belongs to the TPR family.

7955:dydc2
gene id: 7955:dydc2
uniprot id: A0A0G2KNT1
uniprot id: A0A8M2BK95
uniprot id: A0A8M3ARM9
names: Similarity
messages: Belongs to the dpy-30 family.

7955:myo1ha
gene id: 7955:myo1ha
uniprot id: A0A8M3B9I7
uniprot id: A0A8M9QEJ0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:fam32a
gene id: 7955:fam32a
uniprot id: Q6GQN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM32 family.
messages: May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli.
messages: Nucleus

7955:rhot1a
gene id: 7955:rhot1a
uniprot id: A0A8M3AQV6
uniprot id: A0A8M3B0X9
uniprot id: A0A8M3B899
uniprot id: Q6NVC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).
messages: Mitochondrion outer membrane

7955:si:dkey-26g8.4
gene id: 7955:si:dkey-26g8.4
uniprot id: A7MCM3
names: Similarity
messages: Belongs to the peptidase C1 family.

7955:eef1a2
gene id: 7955:eef1a2
uniprot id: Q6DHT2
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

7955:syncripl
gene id: 7955:syncripl
uniprot id: A0A8M2B5D1
uniprot id: A0A8M3ARN6
uniprot id: Q802X5
names: Subcellular Location Annotation
messages: Cytoplasm

7955:arhgef1a
gene id: 7955:arhgef1a
uniprot id: A0A8M9PN51
uniprot id: A0A8M9PRC8
uniprot id: A2RUX1
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Golgi apparatus
messages: Vesicle
messages: spindle
messages: tight junction

7955:aspm
gene id: 7955:aspm
uniprot id: A0A0R4INR1
uniprot id: A0A8M2B8W4
names: Subcellular Location Annotation
messages: Nucleus

7955:slc6a13l
gene id: 7955:slc6a13l
uniprot id: A0A2R8QKW4
uniprot id: A0A8M2BDC6
uniprot id: F1Q5E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:tnfsf18
gene id: 7955:tnfsf18
uniprot id: A9Y5K7
names: Similarity
messages: Belongs to the tumor necrosis factor family.

7955:LOC103909231
gene id: 7955:LOC103909231
uniprot id: A0A8M9PH21
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.

7955:grin2da
gene id: 7955:grin2da
uniprot id: I3NI77
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:zgc:152830
gene id: 7955:zgc:152830
uniprot id: Q08CQ0
names: Similarity
messages: Belongs to the peptidase M17 family.

7955:mios
gene id: 7955:mios
uniprot id: Q802U2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as a E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, MIOS is required to prevent autoubiquitination of WDR24, the catalytic subunit of the complex.
messages: Belongs to the WD repeat mio family.
messages: Component of the GATOR2 subcomplex, composed of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR2 complex interacts with CASTOR1 and CASTOR2; the interaction is negatively regulated by arginine. The GATOR2 complex interacts with SESN1, SESN2 and SESN3; the interaction is negatively regulated by amino acids.
messages: Lysosome membrane
messages: The GATOR2 complex is negatively regulated by the upstream amino acid sensors CASTOR1 and SESN2, which sequester the GATOR2 complex in absence of amino acids. In the presence of abundant amino acids, GATOR2 is released from CASTOR1 and SESN2 and activated.

7955:tshz2
gene id: 7955:tshz2
uniprot id: A0A8M2BLH4
uniprot id: F1QV43
names: Similarity
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.

7955:pycr1b
gene id: 7955:pycr1b
uniprot id: A0A8M9Q700
uniprot id: F1RDD0
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

7955:pik3c2b
gene id: 7955:pik3c2b
uniprot id: F1QWN6
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

7955:ndst1a
gene id: 7955:ndst1a
uniprot id: E7F0G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

7955:calcoco1a
gene id: 7955:calcoco1a
uniprot id: A2BGD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALCOCO family.
messages: Cytoplasm
messages: May function as a coactivator for aryl hydrocarbon and nuclear receptors.
messages: Nucleus

7955:lrp1aa
gene id: 7955:lrp1aa
uniprot id: A0A8M9QD95
names: Caution
names: Similarity
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC799259
gene id: 7955:LOC799259
uniprot id: A0A8M1PUR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

7955:si:dkey-14d8.2
gene id: 7955:si:dkey-14d8.2
uniprot id: A0A8M1P5M3
names: Similarity
messages: Belongs to the SELO family.

7955:olfcg2
gene id: 7955:olfcg2
uniprot id: A0A0R4IDZ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:ucn3l
gene id: 7955:ucn3l
uniprot id: Q1LYP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

7955:LOC100334716
gene id: 7955:LOC100334716
uniprot id: A0A8M9PZN1
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

7955:LOC110439817
gene id: 7955:LOC110439817
uniprot id: A0A8M9PLC1
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

7955:dctn5
gene id: 7955:dctn5
uniprot id: Q6DGN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.
messages: cytoskeleton

7955:itga3a
gene id: 7955:itga3a
uniprot id: A0A8M6YWS7
uniprot id: A0A8M9QA60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

7955:dr1
gene id: 7955:dr1
uniprot id: Q08BR1
names: Similarity
messages: Belongs to the NC2 beta/DR1 family.

7955:lim2.5
gene id: 7955:lim2.5
uniprot id: Q5BKW4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:spon2a
gene id: 7955:spon2a
uniprot id: O42111
names: Subcellular Location Annotation
messages: extracellular matrix

7955:fgf2
gene id: 7955:fgf2
uniprot id: A0A8M9QGC5
uniprot id: B3DGE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Secreted

7955:efnb3a
gene id: 7955:efnb3a
uniprot id: A0A2R8RI02
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:hs6st3b
gene id: 7955:hs6st3b
uniprot id: A0MGZ7
uniprot id: B0S4Y4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
messages: Belongs to the sulfotransferase 6 family.
messages: Expressed both maternally and zygotically.
messages: In early somitogenesis, expressed in presumptive forebrain and midbrain, tail bud and Kupffer's vesicle. During mid-somitogenesis, ubiquitous expression which is strongest in the somites and eye. During late somitogenesis, predominantly expressed in eye, hindbrain and ventral somites. At 24 hours post-fertilization (hpf), restricted to lens and neural retina, brain, otic vesicle and somites. At 36 hpf, brain expression is restricted to telencephalon. At 48 hpf, restricted to telencephalon and pectoral fin.
messages: Membrane

7955:mei4
gene id: 7955:mei4
uniprot id: Q5PNP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MEI4L family.
messages: Chromosome
messages: Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination.

7955:srm
gene id: 7955:srm
uniprot id: F1R3G8
uniprot id: Q7SY20
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

7955:ajap1
gene id: 7955:ajap1
uniprot id: A0A8M2BEF5
names: Subcellular Location Annotation
messages: Membrane

7955:dexi
gene id: 7955:dexi
uniprot id: Q6AXJ3
names: Similarity
messages: Belongs to the DEXI family.

7955:seta
gene id: 7955:seta
uniprot id: Q7ZUY0
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

7955:lmnb2
gene id: 7955:lmnb2
uniprot id: B3DFN3
names: Similarity
messages: Belongs to the intermediate filament family.

7955:crp7
gene id: 7955:crp7
uniprot id: A3KPH5
uniprot id: A7E2J1
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:vasnb
gene id: 7955:vasnb
uniprot id: A4QNV9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:galnt2
gene id: 7955:galnt2
uniprot id: A0A8M3B826
uniprot id: B0V0U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

7955:or128-8
gene id: 7955:or128-8
uniprot id: Q2PRF7
names: Subcellular Location Annotation
messages: Membrane

7955:LOC556668
gene id: 7955:LOC556668
uniprot id: A0A8M3ANJ7
uniprot id: A0A8M3B6P0
uniprot id: A0A8M9P640
names: Domain
names: Similarity
messages: Belongs to the Xin family.
messages: Xin repeats bind F-actin.

7955:gab2
gene id: 7955:gab2
uniprot id: A0A0R4I9X7
names: Similarity
messages: Belongs to the GAB family.

7955:LOC108179093
gene id: 7955:LOC108179093
uniprot id: X1WHH5
names: Similarity
messages: Belongs to the MS4A family.

7955:mxb
gene id: 7955:mxb
uniprot id: B8JKI4
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

7955:bcl2l1
gene id: 7955:bcl2l1
uniprot id: Q90Z98
names: Similarity
messages: Belongs to the Bcl-2 family.

7955:eif4ebp2
gene id: 7955:eif4ebp2
uniprot id: Q6NYL2
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

7955:nr1d2b
gene id: 7955:nr1d2b
uniprot id: Q6GMI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

7955:nckap1
gene id: 7955:nckap1
uniprot id: B0S6R1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEM-1/HEM-2 family.
messages: Cell membrane
messages: Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1 (By similarity). Plays a role in neural tube closure.
messages: lamellipodium membrane

7955:chrnb4
gene id: 7955:chrnb4
uniprot id: A0A0R4ISQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:rraga
gene id: 7955:rraga
uniprot id: Q7ZUI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

7955:saraf
gene id: 7955:saraf
uniprot id: F1QPC3
uniprot id: J9PBQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SARAF family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (stim1 or stim2)-dependent SOCE activity (By similarity).

7955:nudt4a
gene id: 7955:nudt4a
uniprot id: F1QR77
uniprot id: Q1L8L1
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

7955:rspo2
gene id: 7955:rspo2
uniprot id: F1Q5C9
names: Similarity
messages: Belongs to the R-spondin family.

7955:galnt6
gene id: 7955:galnt6
uniprot id: Q6NX01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

7955:spsb4b
gene id: 7955:spsb4b
uniprot id: Q6DBS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Cytoplasm

7955:stc1
gene id: 7955:stc1
uniprot id: Q0P481
names: Function
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.
messages: Its primary function is the prevention of hypercalcemia. Upon release into the circulation, it lowers calcium transport by the gills, thereby reducing its rate of influx from the environment into the extracellular compartment. STC also stimulates phosphate reabsorption by renal proximal tubules. The consequence of this action is increased levels of plasma phosphate, which combines with excess calcium and promotes its disposal into bone and scales.

7955:gpx2
gene id: 7955:gpx2
uniprot id: A0A8M1PAJ9
names: Similarity
messages: Belongs to the glutathione peroxidase family.

7955:map2k5
gene id: 7955:map2k5
uniprot id: A0A8M3BB07
uniprot id: A9JRD0
uniprot id: B1NA67
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:grhl2b
gene id: 7955:grhl2b
uniprot id: A0A2R8QAV0
uniprot id: F7VJQ5
names: Subcellular Location Annotation
messages: Nucleus

7955:rrp15
gene id: 7955:rrp15
uniprot id: Q7ZV20
names: Similarity
messages: Belongs to the RRP15 family.

7955:fam161a
gene id: 7955:fam161a
uniprot id: A0A8M9Q7G2
uniprot id: A0A8N7T6N8
names: Similarity
messages: Belongs to the FAM161 family.

7955:marcksa
gene id: 7955:marcksa
uniprot id: A0A8M2BHW7
uniprot id: G4XPM4
names: Similarity
messages: Belongs to the MARCKS family.

7955:kcnh2a
gene id: 7955:kcnh2a
uniprot id: A0A8M9QG33
uniprot id: A0A8M9QKB0
uniprot id: Q108P2
names: Subcellular Location Annotation
messages: Membrane

7955:cmtm8b
gene id: 7955:cmtm8b
uniprot id: A1L255
names: Subcellular Location Annotation
messages: Membrane

7955:eif4a2
gene id: 7955:eif4a2
uniprot id: F1R166
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

7955:mpdz
gene id: 7955:mpdz
uniprot id: A0A8M3B1P4
uniprot id: A0A8M3B4L4
uniprot id: A0A8M3BBH8
uniprot id: A0A8M6Z0B7
uniprot id: A0A8M6Z1X6
uniprot id: A0A8M6Z7Z1
names: Subcellular Location Annotation
messages: tight junction

7955:si:ch211-191d15.2
gene id: 7955:si:ch211-191d15.2
uniprot id: Q6DC82
names: Similarity
messages: Belongs to the NifU family.

7955:msrb3
gene id: 7955:msrb3
uniprot id: A0A8M1P8M4
uniprot id: Q5TZH6
uniprot id: Q5TZH8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

7955:wu:fb69f10
gene id: 7955:wu:fb69f10
uniprot id: A0A8M1RHZ7
uniprot id: A0A8M2BHP8
uniprot id: F1Q618
names: Similarity
messages: Belongs to the RRM Spen family.

7955:mrpl40
gene id: 7955:mrpl40
uniprot id: Q66I86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL40 family.
messages: Mitochondrion

7955:suclg2
gene id: 7955:suclg2
uniprot id: F1R7X5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.
messages: Mitochondrion

7955:LOC110439819
gene id: 7955:LOC110439819
uniprot id: A0A8M9PLC5
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

7955:tbc1d24
gene id: 7955:tbc1d24
uniprot id: A0A8M1RN56
uniprot id: A0A8M3B6W1
uniprot id: A0A8M9PMI2
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasmic vesicle membrane
messages: Interacts with ARF6.
messages: Membrane
messages: Presynapse

7955:lmx1al
gene id: 7955:lmx1al
uniprot id: F1QFN7
names: Subcellular Location Annotation
messages: Nucleus

7955:sec31b
gene id: 7955:sec31b
uniprot id: A0A8M2BKB4
uniprot id: E7F114
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC31 family.
messages: Endoplasmic reticulum membrane

7955:rnf121
gene id: 7955:rnf121
uniprot id: E7EYE4
names: Subcellular Location Annotation
messages: Membrane

7955:calm3b
gene id: 7955:calm3b
uniprot id: Q6PI52
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the calmodulin family.
messages: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases.
messages: This protein has four functional calcium-binding sites.

7955:dhrs7cb
gene id: 7955:dhrs7cb
uniprot id: A8E5C5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Putative oxidoreductase.
messages: Secreted

7955:fgf9
gene id: 7955:fgf9
uniprot id: A0A8M3B2M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Secreted

7955:tfr1a
gene id: 7955:tfr1a
uniprot id: Q5MPX4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.
messages: Homodimer; disulfide-linked.
messages: Melanosome
messages: Membrane
messages: Stearoylated.

7955:dusp6
gene id: 7955:dusp6
uniprot id: Q7T2L8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

7955:casp6l1
gene id: 7955:casp6l1
uniprot id: A0A8M2BBK1
uniprot id: Q5XJ68
names: Similarity
messages: Belongs to the peptidase C14A family.

7955:taar13d
gene id: 7955:taar13d
uniprot id: Q5QNQ1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:foxp1b
gene id: 7955:foxp1b
uniprot id: A0A8M3ATJ4
uniprot id: A0A8M9PM82
uniprot id: A0A8M9PZW2
uniprot id: A0A8M9Q673
uniprot id: Q2LE08
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed both maternally and zygotically with continuous expression from the zygote to the early larva. Expression dramatically decreases at 30 and 50% epiboly stages, then increases from midgastrulaion onwards, being maintained at a high level until the protruding-mouth stage.
messages: Nucleus
messages: Shows complex and dynamic expression during early embryonic development. Prominent in many regions of the developing central nervous system, particularly in midbrain-hindbrain boundary, hindbrain and spinal cord. Strongly expressed in the retina, ear, branchial arches, hatching gland, heart, pronephric duct, gut, proctodeum, pectoral fin and swim bladder.
messages: The leucine-zipper is required for dimerization and transcriptional repression.
messages: Transcriptional repressor.

7955:si:dkey-286h2.7
gene id: 7955:si:dkey-286h2.7
uniprot id: A0A1L1QZC0
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:si:ch211-254p10.2
gene id: 7955:si:ch211-254p10.2
uniprot id: A0A8M9PMZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
messages: Lateral cell membrane
messages: May be involved in iron transport and iron homeostasis.
messages: Membrane

7955:LOC793750
gene id: 7955:LOC793750
uniprot id: A0A0G2KD19
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:nphp3
gene id: 7955:nphp3
uniprot id: P0CI65
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Morpholino knockdown of the protein in the embryo causes ventral body curvature, pronephric cyst formation and laterality defects, including reversed heart looping.
messages: Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling that regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements.
messages: cilium

7955:mcm5
gene id: 7955:mcm5
uniprot id: Q6NV07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

7955:gpt2
gene id: 7955:gpt2
uniprot id: A0A8M1NDP9
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

7955:iqcd
gene id: 7955:iqcd
uniprot id: A0A8M9Q9C0
uniprot id: F6P8U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC10 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
messages: flagellum axoneme

7955:phf2
gene id: 7955:phf2
uniprot id: A0A8M2BGL0
uniprot id: A0A8M2BH62
uniprot id: Q6P949
names: Caution
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.
messages: Contaminating sequence. Potential poly-A sequence.
messages: In contrast to the related histone demethylases jhdm1d and phf8, the conserved active His in position 321 is replaced by an Asn. However, the presence of an Asn residue neither affects binding to the catalytic iron nor abolishes demethylase activity.
messages: Lysine demethylase that demethylates both histones and non-histone proteins. Mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2). Recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (By similarity).
messages: kinetochore
messages: nucleolus

7955:st7
gene id: 7955:st7
uniprot id: Q1RLU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

7955:si:dkey-222h21.12
gene id: 7955:si:dkey-222h21.12
uniprot id: A0A8M9QIG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
messages: Membrane

7955:gfm2
gene id: 7955:gfm2
uniprot id: A0JMI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with mrrf. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
messages: Mitochondrion

7955:gpatch11
gene id: 7955:gpatch11
uniprot id: Q6DGZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPATCH11 family.
messages: kinetochore

7955:hgfa
gene id: 7955:hgfa
uniprot id: F1REK1
uniprot id: Q5RGG3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

7955:pbx2
gene id: 7955:pbx2
uniprot id: A0A8M6YV86
uniprot id: Q9I9B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

7955:LOC110437811
gene id: 7955:LOC110437811
uniprot id: A0A8M9PN70
uniprot id: A0A8M9PYX1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:zgc:162707
gene id: 7955:zgc:162707
uniprot id: A3KNX6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the UPF0524 family.
messages: Double knockout of c3orf70a and c3orf70b resulted in significantly decreased expression of the mature neuron markers elavl3 and eno2 and the midbrain/hindbrain marker irx3b. Neurobehaviors related to circadian rhythm and altered light-dark conditions were significantly impaired.
messages: Highly expressed in the gut, myotomes and brain, especially the midbrain and hindbrain, at 3 days post-fertilization (dpf).
messages: Plays a role in neuronal and neurobehavioral development (PubMed:31623237). Required for normal expression of the postmitotic and mature neuron markers elavl3 and eno2 and neurobehaviors related to circadian rhythm and altered light-dark conditions (PubMed:31623237).

7955:ahcy
gene id: 7955:ahcy
uniprot id: Q803T5
names: Cofactor
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.

7955:tjp1b
gene id: 7955:tjp1b
uniprot id: A0A8M3AP85
uniprot id: A0A8M3APU8
uniprot id: A0A8M3AWQ4
uniprot id: A0A8M3AZT7
uniprot id: A0A8M3B7C4
uniprot id: A0A8M6YWL0
uniprot id: A0A8M6YYG5
uniprot id: A0A8M9P6X7
uniprot id: A0A8M9P6Y1
uniprot id: A0A8M9P6Y5
uniprot id: A0A8M9PHF8
uniprot id: A0A8M9PHG3
uniprot id: A0A8M9PHG7
uniprot id: A0A8M9PNE2
uniprot id: A0A8M9PNF2
uniprot id: A0A8M9PVM8
uniprot id: A0A8M9PVN3
uniprot id: A0A8M9PVN8
uniprot id: A0A8M9PZ36
uniprot id: A0A8M9PZ42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Membrane
messages: tight junction

7955:dysf
gene id: 7955:dysf
uniprot id: A0A8M2BJL7
uniprot id: A0A8M9PNZ9
uniprot id: A0A8M9Q1P0
uniprot id: A0A8M9Q7X3
uniprot id: A0A8M9QC21
uniprot id: A0A8M9QH25
uniprot id: A0A8M9QH31
uniprot id: E7F4H1
uniprot id: F1QIS3
uniprot id: F6IA09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferlin family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

7955:nmt1a
gene id: 7955:nmt1a
uniprot id: Q4VBR7
names: Function
names: Similarity
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.

7955:ba1l
gene id: 7955:ba1l
uniprot id: B3DG37
uniprot id: Q90486
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from gills to the various peripheral tissues.
messages: Red blood cells.

7955:ppie
gene id: 7955:ppie
uniprot id: Q561T2
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.

7955:slc38a7
gene id: 7955:slc38a7
uniprot id: Q6DEL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Lysosome membrane
messages: Symporter that selectively cotransports sodium ions and amino acids, such as L-glutamine and L-asparagine from the lysosome into the cytoplasm and may participates in mTORC1 activation. The transport activity requires an acidic lysosomal lumen.
messages: axon

7955:agtrap
gene id: 7955:agtrap
uniprot id: A0A8M9QHT1
uniprot id: E7F2K3
names: Subcellular Location Annotation
messages: Membrane

7955:spns2
gene id: 7955:spns2
uniprot id: A2SWM2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Cell membrane
messages: Disrupted formation of the primitive heart tube.
messages: Endosome membrane
messages: Induced at the marginal cells of the blastoderm at dome stage. During gastrulation stages, it is predominantly expressed in the extraembryonic yolk syncytial layer (YSL) with a dorsal-to-ventral gradient. Expression in the YSL is strongly detected just below the developing myocardial precursors and maintained throughout segmentation period. This expression continues through early somitogenesis. However, as somitogenesis proceeds, expression domains become evident in the somitic mesoderm and in the endoderm adjacent to the yolk extension. By 24 hpf, it is strongly expressed in a distinct compartment of the somites, in the endoderm, and in the heart.
messages: Lipid transporter that specifically mediates export of sphingosine-1-phosphate (sphing-4-enine 1-phosphate, S1P) and sphinganine-1-phosphate, which play critical roles in regulating heart development (PubMed:19062281, PubMed:19074308). Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration (PubMed:19062281, PubMed:19074308).

7955:si:dkey-79d12.5
gene id: 7955:si:dkey-79d12.5
uniprot id: A0A8M9P8B7
uniprot id: E7F2Z6
names: Similarity
messages: Belongs to the BTG family.

7955:apbb1ip
gene id: 7955:apbb1ip
uniprot id: Q6PFT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling.
messages: Belongs to the MRL family.
messages: Cell membrane
messages: cytoskeleton

7955:ap1g1
gene id: 7955:ap1g1
uniprot id: A0A8M6YZX7
uniprot id: A0A8M6Z1G8
uniprot id: Q7ZUU8
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

7955:zgc:110782
gene id: 7955:zgc:110782
uniprot id: Q5BLA6
names: Similarity
messages: Belongs to the aldo/keto reductase family.

7955:bnip4
gene id: 7955:bnip4
uniprot id: F1QZM4
uniprot id: Q32PK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

7955:zgc:65895
gene id: 7955:zgc:65895
uniprot id: Q6NZS2
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

7955:nbeal2
gene id: 7955:nbeal2
uniprot id: E7FAW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat neurobeachin family.
messages: Endoplasmic reticulum
messages: Involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis.

7955:rc3h1a
gene id: 7955:rc3h1a
uniprot id: B3DIY0
uniprot id: Q1LV60
names: Subcellular Location Annotation
messages: P-body

7955:ryr2a
gene id: 7955:ryr2a
uniprot id: A0A8M9PWM5
names: Subcellular Location Annotation
messages: Membrane
messages: Sarcoplasmic reticulum membrane

7955:pgfa
gene id: 7955:pgfa
uniprot id: A0A8M9PTL4
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

7955:rcl1
gene id: 7955:rcl1
uniprot id: A0A8M9Q8F5
uniprot id: Q6DRI3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: nucleolus

7955:aqp3b
gene id: 7955:aqp3b
uniprot id: D3TI80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

7955:tgfbr2b
gene id: 7955:tgfbr2b
uniprot id: Q58EQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

7955:fbxo5
gene id: 7955:fbxo5
uniprot id: Q0V967
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: During embryonic development, regulates the integrity of the genome and therefore the cell cycle progression by preventing rereplication through an APC-Cdh1-dependent mechanism.
messages: Nucleus
messages: Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

7955:si:ch73-74h11.1
gene id: 7955:si:ch73-74h11.1
uniprot id: F1R480
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: desmosome

7955:lrrfip1a
gene id: 7955:lrrfip1a
uniprot id: A0A8M2BF13
uniprot id: A0A8M3BCG7
uniprot id: A0A8M9PA40
uniprot id: A0A8M9PA47
uniprot id: A0A8M9PLF4
uniprot id: A0A8M9PSJ5
uniprot id: A0A8M9PSK0
uniprot id: A0A8M9PSU5
uniprot id: A0A8M9PSV0
uniprot id: A0A8M9PZR4
uniprot id: A0A8M9PZR9
uniprot id: A0A8M9Q321
uniprot id: A0A8M9Q531
uniprot id: A0A8M9QBC1
uniprot id: A0A8M9QBD2
uniprot id: A0A8M9QBD6
uniprot id: A0A8M9QFZ3
uniprot id: A0A8M9QFZ6
uniprot id: A0A8M9QG03
uniprot id: A0A8M9QK54
uniprot id: A0A8M9QK63
uniprot id: A0A8M9QK65
names: Similarity
messages: Belongs to the LRRFIP family.

7955:LOC100331268
gene id: 7955:LOC100331268
uniprot id: A0A8M1RH25
uniprot id: A0A8M9PM28
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

7955:col4a5
gene id: 7955:col4a5
uniprot id: A0A8M2BDZ6
uniprot id: A0A8M9QBN0
uniprot id: A0A8N7UYU7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

7955:ms4a17a.17
gene id: 7955:ms4a17a.17
uniprot id: A3KNL7
names: Similarity
messages: Belongs to the MS4A family.

7955:adrb2a
gene id: 7955:adrb2a
uniprot id: I7GPU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:phyhip
gene id: 7955:phyhip
uniprot id: A0A2R8QFV4
names: Similarity
messages: Belongs to the PHYHIP family.

7955:cox7a2b
gene id: 7955:cox7a2b
uniprot id: A0A2R8Q5H6
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

7955:bola3
gene id: 7955:bola3
uniprot id: Q6DC87
names: Similarity
messages: Belongs to the BolA/IbaG family.

7955:pmvk
gene id: 7955:pmvk
uniprot id: A4IGD4
names: Subcellular Location Annotation
messages: cytosol

7955:nploc4
gene id: 7955:nploc4
uniprot id: Q7ZVI8
names: Similarity
messages: Belongs to the NPL4 family.

7955:mgrn1a
gene id: 7955:mgrn1a
uniprot id: B0JZJ6
uniprot id: B7ZVH3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin ligase.

7955:abcc6b.2
gene id: 7955:abcc6b.2
uniprot id: A0A140LGU2
uniprot id: A0A8M6YXP8
uniprot id: A0A8M9PZJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

7955:tlr1
gene id: 7955:tlr1
uniprot id: B3DIW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

7955:tp53i11a
gene id: 7955:tp53i11a
uniprot id: Q5CZU4
names: Subcellular Location Annotation
messages: Membrane

7955:jmjd6
gene id: 7955:jmjd6
uniprot id: Q6PFM0
names: Caution
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: After the somite segmentation period, it is apparent throughout the embryo and the hatching gland. At the larval (3 dpf) stage, it is detected in the heart and kidney.
messages: Belongs to the JMJD6 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as u2af2/u2af65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of u2af2/u2af65, affecting the pre-mRNA splicing activity of u2af2/u2af65. Hydroxylates its own N-terminus, which is required for homooligomerization. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation. Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. In collaboration with brd4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. Demethylates other arginine methylated-proteins such as esr1. Has no histone lysine demethylase activity (By similarity). Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation (By similarity).
messages: Expressed in embryos from the one-cell developmental stage to the 3 days post-fertilization (dpf) larval stage.
messages: Fishes display an accumulation of a large number of dead apoptotic cells in whole early embryo. These cells interfere with embryonic cell migration. In addition, normal development of the somite, brain, heart and notochord are sequentially disrupted up to 24 hours post-fertilization.
messages: Hydroxylates its own N-terminus; hydroxylation is required for homooligomerization.
messages: The nuclear localization signal motifs are necessary and sufficient to target it into the nucleus.
messages: Was initially thought to constitute the phosphatidylserine receptor, a receptor that mediates recognition of phosphatidylserine, a specific marker only present at the surface of apoptotic cells, and participates in apoptotic cell phagocytosis. However, some results strongly suggest that it does not constitute the receptor for phosphatidylserine and is not involved in apoptotic cell removal.
messages: nucleolus
messages: nucleoplasm

7955:mdn1
gene id: 7955:mdn1
uniprot id: A0A8M1RP38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the midasin family.
messages: Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.
messages: nucleolus
messages: nucleoplasm

7955:cpne1
gene id: 7955:cpne1
uniprot id: A0A8M2BGH9
uniprot id: A0A8M2BH47
uniprot id: A0A8M6Z114
uniprot id: F1QNY5
uniprot id: Q6TEN9
names: Similarity
messages: Belongs to the copine family.

7955:si:ch211-140m22.7
gene id: 7955:si:ch211-140m22.7
uniprot id: A0A2R8RW11
uniprot id: A0A8M3AVZ6
uniprot id: A0A8M3B2M1
uniprot id: A0A8M3B5K9
uniprot id: A0A8M3BCF4
uniprot id: A0A8M9PSB8
uniprot id: A0A8M9Q4P8
uniprot id: A0A8M9QAX5
uniprot id: A0A8M9QJT6
uniprot id: E7F2K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion

7955:cyp2k22
gene id: 7955:cyp2k22
uniprot id: Q802X8
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:LOC100330283
gene id: 7955:LOC100330283
uniprot id: A0A8M2BLG6
names: Subcellular Location Annotation
messages: Membrane

7955:slc14a2
gene id: 7955:slc14a2
uniprot id: A0A8M9Q878
uniprot id: Q533H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

7955:tmprss15
gene id: 7955:tmprss15
uniprot id: F1RER3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMBT1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:rae1
gene id: 7955:rae1
uniprot id: Q7ZWF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat rae1 family.
messages: Cytoplasm
messages: Nucleus
messages: Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.
messages: spindle pole

7955:rnasel2
gene id: 7955:rnasel2
uniprot id: A5HAK1
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

7955:naa38
gene id: 7955:naa38
uniprot id: A2BIG9
uniprot id: A7E284
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of naa35, naa38 and naa30.
messages: Cytoplasm

7955:abcg4a
gene id: 7955:abcg4a
uniprot id: A2BFT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

7955:irgf3
gene id: 7955:irgf3
uniprot id: E7F6D1
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

7955:gnb1b
gene id: 7955:gnb1b
uniprot id: Q803H5
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

7955:tmem136a
gene id: 7955:tmem136a
uniprot id: E7F142
names: Subcellular Location Annotation
messages: Membrane

7955:relt
gene id: 7955:relt
uniprot id: Q6NZ11
names: Similarity
messages: Belongs to the RELT family.

7955:bcorl1
gene id: 7955:bcorl1
uniprot id: A0A8M1PRS1
uniprot id: A0A8M2BKM1
uniprot id: A0A8M2BKM5
names: Similarity
messages: Belongs to the BCOR family.

7955:cpeb1b
gene id: 7955:cpeb1b
uniprot id: A0A8M9Q7I0
uniprot id: A2CE67
uniprot id: Q9YGX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the RRM CPEB family.
messages: Cytoplasm
messages: Expressed in oocytes (at protein level). During oocyte maturation becomes detectable at stage Ib, and remains ubiquitously distributed within the oocyte cytoplasm until stage II. It then follows a gradual accumulation to the future animal pole during stage III, and remains localized to this pole at stage IV (at protein level). Expressed in oocytes, blastomeres and pre-mid-blastula transition embryos. Its expression during oogenesis is ubiquitous at stages I and II, but gradually accumulated at the periphery of the oocyte in the presumptive animal pole during stage III. Expression was maintained in that region at stage IV, and then became delocalized at stage V to cover a much broader area presumably encompassing the future blastodisc.
messages: Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation and early development. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (By similarity).

7955:zgc:162193
gene id: 7955:zgc:162193
uniprot id: A4IG42
uniprot id: F1QL62
names: Function
names: Similarity
messages: Belongs to the TCAF family.
messages: May play a role in the regulation of the cation channel TRPM8 activity.

7955:ndufa10
gene id: 7955:ndufa10
uniprot id: Q6PBM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA10 subunit family.
messages: Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.
messages: Mitochondrion matrix

7955:d2hgdh
gene id: 7955:d2hgdh
uniprot id: A1L258
uniprot id: F1R1R3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
messages: Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate (By similarity). Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC) (By similarity). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC (By similarity).
messages: Mitochondrion

7955:dnajc27
gene id: 7955:dnajc27
uniprot id: Q6IMK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: GTPase possibly involved in regulation of the MEK/ERK pathway.
messages: Nucleus

7955:epdl2
gene id: 7955:epdl2
uniprot id: F1R8R9
names: Similarity
messages: Belongs to the ependymin family.

7955:clcnk
gene id: 7955:clcnk
uniprot id: A0A8M9PKM9
uniprot id: Q7T329
names: Subcellular Location Annotation
messages: Membrane

7955:LOC798483
gene id: 7955:LOC798483
uniprot id: A0A8M1Q7E1
names: Similarity
messages: Belongs to the CD225/Dispanin family.

7955:vetz
gene id: 7955:vetz
uniprot id: A0A0R4IYV3
uniprot id: A0A8M2BC40
uniprot id: A8WFS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vezatin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: adherens junction

7955:pih1d1
gene id: 7955:pih1d1
uniprot id: A0A8M1NRJ1
uniprot id: A0A8M3AQY5
names: Similarity
messages: Belongs to the PIH1 family.

7955:sugct
gene id: 7955:sugct
uniprot id: A0A8M9PG48
uniprot id: A0A8M9PLX4
uniprot id: Q4V9F2
names: Similarity
messages: Belongs to the CoA-transferase III family.

7955:cyp2k18
gene id: 7955:cyp2k18
uniprot id: A0A8M2BB11
uniprot id: Q7SX96
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:zgc:153654
gene id: 7955:zgc:153654
uniprot id: B0S6B5
names: Similarity
messages: Belongs to the IFI44 family.

7955:zmpste24
gene id: 7955:zmpste24
uniprot id: Q802Z1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

7955:chrna10a
gene id: 7955:chrna10a
uniprot id: Q1LY90
uniprot id: R4GF05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:chst12b
gene id: 7955:chst12b
uniprot id: A0A8M2B6G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:rtn1b
gene id: 7955:rtn1b
uniprot id: A0A8M2B7D0
uniprot id: F1R540
uniprot id: Q4G5W6
uniprot id: Q5TZI1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:prmt8b
gene id: 7955:prmt8b
uniprot id: Q5RGQ2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT8 subfamily.
messages: Cell membrane
messages: Homodimer. Tetramer; individual homodimers associates to form a homotetramer. Homooctamer; individual homodimers associates to form a homooctamer and homooligomerization is required for proper localization to the cell membrane.
messages: S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA).
messages: The N-terminal region (1-60) inhibits the arginine N-methyltransferase activity.

7955:chid1
gene id: 7955:chid1
uniprot id: Q7SYK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family.
messages: Lysosome
messages: Secreted

7955:LOC110440113
gene id: 7955:LOC110440113
uniprot id: A0A8M9PVT8
names: Subcellular Location Annotation
messages: Nucleus

7955:dyrk1aa
gene id: 7955:dyrk1aa
uniprot id: A0A8M1P9M8
uniprot id: A1L1U2
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

7955:neflb
gene id: 7955:neflb
uniprot id: Q29RE8
names: Similarity
messages: Belongs to the intermediate filament family.

7955:LOC571912
gene id: 7955:LOC571912
uniprot id: A0A8M2B4Y9
uniprot id: F1QWD1
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

7955:agla
gene id: 7955:agla
uniprot id: A0A0R4IV67
uniprot id: A0A8M2BAR0
uniprot id: A0A8M3AQ64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.

7955:cxcl13
gene id: 7955:cxcl13
uniprot id: A0A8M2BCP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

7955:afg1lb
gene id: 7955:afg1lb
uniprot id: A0A8M9PBQ8
uniprot id: Q5TYS0
names: Similarity
messages: Belongs to the AFG1 ATPase family.

7955:zic4
gene id: 7955:zic4
uniprot id: A0A8M9PU73
uniprot id: B2BM15
uniprot id: Q08BV0
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

7955:sbk3
gene id: 7955:sbk3
uniprot id: A8WFZ8
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:tipin
gene id: 7955:tipin
uniprot id: A0A8M2BGP4
uniprot id: G1K2L6
uniprot id: Q6DBR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSM3 family.
messages: Cytoplasm
messages: Interacts with TIMELESS, which impairs TIMELESS self-association.
messages: Nucleus
messages: Plays an important role in the control of DNA replication and the maintenance of replication fork stability.
messages: Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be required for the replication checkpoint induced by hydroxyurea or ultraviolet light (By similarity).

7955:hyi
gene id: 7955:hyi
uniprot id: F1QNK8
uniprot id: Q7T3H9
names: Function
names: Similarity
messages: Belongs to the hyi family.
messages: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).

7955:c5
gene id: 7955:c5
uniprot id: E7FCV2
names: Subcellular Location Annotation
messages: Secreted

7955:cdkn1bb
gene id: 7955:cdkn1bb
uniprot id: Q90YX4
names: Similarity
messages: Belongs to the CDI family.

7955:trappc1
gene id: 7955:trappc1
uniprot id: A0A8M9PT12
uniprot id: F1QJL7
uniprot id: Q6DGD9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

7955:LOC793010
gene id: 7955:LOC793010
uniprot id: A0A8M9PSA6
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:zgc:172302
gene id: 7955:zgc:172302
uniprot id: A0A8M1QLA5
uniprot id: A0A8M3B3V5
names: Subcellular Location Annotation
messages: Membrane

7955:olfcs2
gene id: 7955:olfcs2
uniprot id: A0A0R4IW17
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:si:dkey-40c23.1
gene id: 7955:si:dkey-40c23.1
uniprot id: A0A8M3B6N3
uniprot id: A0A8M3BDF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

7955:si:dkey-23a13.6
gene id: 7955:si:dkey-23a13.6
uniprot id: Q4FZZ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:slc7a3b
gene id: 7955:slc7a3b
uniprot id: F1QNI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

7955:efhb
gene id: 7955:efhb
uniprot id: E7F7T9
names: Subcellular Location Annotation
messages: cilium axoneme

7955:itga1
gene id: 7955:itga1
uniprot id: A0A8M9QGT0
uniprot id: A0A8M9QKV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

7955:slc16a12a
gene id: 7955:slc16a12a
uniprot id: E7FGJ9
names: Subcellular Location Annotation
messages: Membrane

7955:cnot7
gene id: 7955:cnot7
uniprot id: A0A8M9QB61
uniprot id: A0A8M9QKP5
uniprot id: Q08BM8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CAF1 family.
messages: Binds 2 divalent metal cations per subunit with RNAase activity being higher in presence of Mn(2+) than of Mg(2+) or Co(2+).
messages: Component of the CCR4-NOT complex.
messages: Cytoplasm
messages: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression (By similarity).
messages: Nucleus

7955:si:ch211-173d10.1
gene id: 7955:si:ch211-173d10.1
uniprot id: S5TZ97
names: Subcellular Location Annotation
messages: Membrane

7955:pou3f3a
gene id: 7955:pou3f3a
uniprot id: P56224
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Isoform 2 is expressed both maternally and zygotically, and is the major isoform in adults. Isoform 1 and isoform 3 are expressed zygotically. Maximal expression is after 1 to 2 days of development and becomes down-regulated as cells differentiate.
messages: Nucleus
messages: Predominantly expressed in the embryonic and adult central nervous system. In adults, isoform 2 is expressed in the brain, ovary, basal cells of the skin and muscle satellite cells.
messages: Transcription factor that may play important roles in patterning the embryonic brain.

7955:zgc:158803
gene id: 7955:zgc:158803
uniprot id: A3KMT0
names: Similarity
messages: Belongs to the Luc7 family.

7955:sstr3
gene id: 7955:sstr3
uniprot id: A2BHH9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:snu13a
gene id: 7955:snu13a
uniprot id: Q7ZU93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

7955:itga6a
gene id: 7955:itga6a
uniprot id: A8WHQ7
uniprot id: A8WHQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

7955:prpf3
gene id: 7955:prpf3
uniprot id: A4QP06
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).

7955:plrg1
gene id: 7955:plrg1
uniprot id: Q6DRE2
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

7955:znf750
gene id: 7955:znf750
uniprot id: Q568E2
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription factor involved in epidermis differentiation.

7955:nt5c2a
gene id: 7955:nt5c2a
uniprot id: A0A8M2B3I7
uniprot id: A0A8M9QJJ3
uniprot id: E7FC21
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

7955:stam2
gene id: 7955:stam2
uniprot id: A8WI00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane

7955:npy8br
gene id: 7955:npy8br
uniprot id: O57463
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:cldn11a
gene id: 7955:cldn11a
uniprot id: Q6DHL0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

7955:si:dkey-30g5.1
gene id: 7955:si:dkey-30g5.1
uniprot id: A0A8M3ATP6
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:irf2a
gene id: 7955:irf2a
uniprot id: F1Q8A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Nucleus

7955:LOC570372
gene id: 7955:LOC570372
uniprot id: A0A8M9Q975
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane

7955:si:ch73-36p18.5
gene id: 7955:si:ch73-36p18.5
uniprot id: Q4FZZ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:tmc6b
gene id: 7955:tmc6b
uniprot id: Q6DH78
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:stra13
gene id: 7955:stra13
uniprot id: E7F1X6
names: Similarity
messages: Belongs to the CENP-X/MHF2 family.

7955:iscub
gene id: 7955:iscub
uniprot id: F1QM53
uniprot id: Q568F2
names: Similarity
messages: Belongs to the NifU family.

7955:cdk2ap1
gene id: 7955:cdk2ap1
uniprot id: A0A8M6Z0Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDK2AP family.
messages: Nucleus

7955:rfx3
gene id: 7955:rfx3
uniprot id: A0A8M9PTM1
uniprot id: A0JMF8
uniprot id: B2GSV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFX family.
messages: Nucleus
messages: Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development.

7955:thrap3a
gene id: 7955:thrap3a
uniprot id: A0A0R4IWK3
uniprot id: A0A8M3AIC8
uniprot id: A0A8M3AQV5
uniprot id: A0A8M9PN52
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

7955:colgalt1
gene id: 7955:colgalt1
uniprot id: X1WCE6
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

7955:sox4a
gene id: 7955:sox4a
uniprot id: Q6P0Z4
names: Subcellular Location Annotation
messages: Nucleus

7955:LOC101884770
gene id: 7955:LOC101884770
uniprot id: A0A8M9QCC7
names: Similarity
messages: Belongs to the helicase family.

7955:glb1l
gene id: 7955:glb1l
uniprot id: F1QXE8
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

7955:capn5a
gene id: 7955:capn5a
uniprot id: A0JMG3
names: Similarity
messages: Belongs to the peptidase C2 family.

7955:tnfsf13b
gene id: 7955:tnfsf13b
uniprot id: A0A8M6Z8G0
uniprot id: A0A8M9QAS7
uniprot id: A8WG11
names: Similarity
messages: Belongs to the tumor necrosis factor family.

7955:glg1a
gene id: 7955:glg1a
uniprot id: A0A8M1PU45
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Golgi outpost
messages: Membrane
messages: microtubule organizing center

7955:col4a4
gene id: 7955:col4a4
uniprot id: X1WFR7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

7955:mylpfa
gene id: 7955:mylpfa
uniprot id: O93409
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subunit
messages: Expressed in both embryos and adult fish, and the expression is specifically in fast skeletal muscle.
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains. Interacts with nanos3; the interaction negatively regulates mylpfa phosphorylation (PubMed:20673786).
messages: Myosin regulatory subunit that plays a role to maintain muscle integrity during early development (PubMed:32707087). Plays a role in muscle contraction (PubMed:32707087).
messages: Reduced trunk contractile force and complete pectoral fin paralysis. Muscle weakness is most pronounced in an appendicular muscle and is explained by reduced myosin activity and fiber degeneration.

7955:itga5
gene id: 7955:itga5
uniprot id: Q5I2A9
uniprot id: Q6QAF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

7955:LOC100537396
gene id: 7955:LOC100537396
uniprot id: A0A8M1RSE8
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:eri2
gene id: 7955:eri2
uniprot id: Q502M8
names: Cofactor
names: Similarity
messages: Belongs to the ERI2 family.
messages: Binds 2 magnesium ions per subunit.

7955:plaub
gene id: 7955:plaub
uniprot id: A0A8M9Q858
uniprot id: G8CXX6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC794939
gene id: 7955:LOC794939
uniprot id: A0A286YBQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

7955:vegfba
gene id: 7955:vegfba
uniprot id: E7EZR4
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

7955:fam213b
gene id: 7955:fam213b
uniprot id: Q6NV24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin-like PRXL2 family. Prostamide/prostaglandin F synthase subfamily.
messages: Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity).
messages: cytosol

7955:fuom
gene id: 7955:fuom
uniprot id: Q7ZZ03
names: Function
names: Similarity
messages: Belongs to the RbsD / FucU family.
messages: Involved in the interconversion between alpha- and beta-L-fucoses.

7955:mark3a
gene id: 7955:mark3a
uniprot id: A0A2R8QKT7
uniprot id: A0A8M9PXN3
uniprot id: E9QEM6
uniprot id: Q802W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

7955:stn1
gene id: 7955:stn1
uniprot id: B8JKF4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTC1 family.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.
messages: Component of the CST complex.
messages: Morpholino knockdown in embryos results in decreased red blood cells and an arrest in T-cell progenitors, as well as increased vascularity. The vascular defects could be rescued by wild-type gene and by thalidomide treatment.
messages: Nucleus
messages: telomere

7955:hmgcra
gene id: 7955:hmgcra
uniprot id: A9JSZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMG-CoA reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Peroxisome membrane

7955:LOC100004848
gene id: 7955:LOC100004848
uniprot id: A0A8M9PGM7
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:ier3ip1
gene id: 7955:ier3ip1
uniprot id: Q4VBI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YOS1 family.
messages: Endoplasmic reticulum membrane
messages: Regulator of endoplasmic reticulum secretion that acts as a key determinant of brain size. Required for secretion of extracellular matrix proteins. Required for correct brain development by depositing sufficient extracellular matrix proteins for tissue integrity and the proliferation of neural progenitors (By similarity). Acts as a regulator of the unfolded protein response (UPR) (By similarity).

7955:cluha
gene id: 7955:cluha
uniprot id: A0A8M2B4F2
uniprot id: A0A8M2B4G7
uniprot id: A0A8M9QHB0
uniprot id: A0JMD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLU family.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.
messages: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis.

7955:msi1
gene id: 7955:msi1
uniprot id: Q5BKV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Musashi family.
messages: Cytoplasm

7955:sqstm1
gene id: 7955:sqstm1
uniprot id: F1Q5Z8
names: Subcellular Location Annotation
messages: autophagosome

7955:adgrl4
gene id: 7955:adgrl4
uniprot id: A0A140TAT8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:mast4
gene id: 7955:mast4
uniprot id: A0A8M1QHR2
uniprot id: A0A8M3ASQ2
uniprot id: A0A8M3AST5
uniprot id: A0A8M3AZY5
uniprot id: A0A8M3B9X6
uniprot id: A0A8M6YYJ0
uniprot id: A0A8M9PLG0
uniprot id: A0A8M9PZ29
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

7955:clul1
gene id: 7955:clul1
uniprot id: A5PMY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clusterin family.
messages: Secreted

7955:LOC100329768
gene id: 7955:LOC100329768
uniprot id: A0A8M3AV83
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:fmo5
gene id: 7955:fmo5
uniprot id: Q7T1D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

7955:camk2b1
gene id: 7955:camk2b1
uniprot id: A0A8M3AS35
uniprot id: A0A8M3AS42
uniprot id: A0A8M3AS95
uniprot id: A0A8M3ASA1
uniprot id: A0A8M3ASA5
uniprot id: A0A8M3AZF1
uniprot id: A0A8M3AZF7
uniprot id: A0A8M3B2B5
uniprot id: A0A8M3B2B8
uniprot id: A0A8M3B2C2
uniprot id: A0A8M3B9H1
uniprot id: A0A8M3B9H5
uniprot id: A0A8M3B9H8
uniprot id: A0A8M9PKA6
uniprot id: A0A8M9PKB1
uniprot id: A0A8M9PKB9
uniprot id: A0A8M9PKC4
uniprot id: A0A8M9PKD0
uniprot id: A0A8M9PKD4
uniprot id: A0A8M9PXS6
uniprot id: A0A8M9PXT2
uniprot id: A0A8M9PXT7
uniprot id: A0A8M9PXU3
uniprot id: A0A8M9PXV5
uniprot id: A0A8M9Q3H8
uniprot id: A0A8M9Q3I2
uniprot id: A0A8M9Q3I6
uniprot id: A0A8M9Q3J3
uniprot id: A0A8M9Q3J8
uniprot id: A0A8M9Q3K3
uniprot id: A0A8M9Q3K8
uniprot id: A0A8M9Q8S5
uniprot id: A0A8M9Q8S9
uniprot id: A0A8M9Q8T4
uniprot id: A0A8M9Q8T9
uniprot id: A0A8M9Q8U4
uniprot id: A0A8M9Q8U9
uniprot id: A0A8M9QE37
uniprot id: A0A8M9QE42
uniprot id: A0A8M9QE46
uniprot id: A0A8M9QE51
uniprot id: A0A8M9QE54
uniprot id: A0A8M9QE58
uniprot id: E9QDQ2
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

7955:adgrf3b
gene id: 7955:adgrf3b
uniprot id: A0A8N7UVY3
names: Subcellular Location Annotation
messages: Membrane

7955:olfcd3
gene id: 7955:olfcd3
uniprot id: F1QS61
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:aff3
gene id: 7955:aff3
uniprot id: A0A8M3AW05
names: Similarity
messages: Belongs to the AF4 family.

7955:psme2
gene id: 7955:psme2
uniprot id: Q9PUC4
names: Similarity
messages: Belongs to the PA28 family.

7955:LOC100004411
gene id: 7955:LOC100004411
uniprot id: A0A8M1Q266
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:cox7a1
gene id: 7955:cox7a1
uniprot id: Q08CE7
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

7955:aim1a
gene id: 7955:aim1a
uniprot id: F1QAH5
uniprot id: F1QE29
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:ormdl3
gene id: 7955:ormdl3
uniprot id: Q5XJR6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORM family.
messages: Ceramide-sensitive subunit of the serine palmitoyltransferase (SPT) complex, which is also composed of SPTLC1, SPTLC2/3 and SPTSSA/B.
messages: Ceramides bind to ORMDL3 N-terminus and stabilize it in a conformation that physically restricts the accessibility of the substrates to their binding sites in the serine palmitoyltransferase (SPT) complex, hence inhibiting SPT catalytic activity. In the absence of ceramides, the N-terminus is flexible and permits substrate binding, thus liberating SPT from inhibition.
messages: Endoplasmic reticulum membrane
messages: Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels. When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis.
messages: When hydroxylated at Pro-137, ubiquitinated via 'Lys-48'-linkage, leading to proteasomal degradation. In endothelial cells, ORMDL3 proteasomal degradation is controlled by the sphingosine 1-phosphate receptor signaling pathway.

7955:LOC101885301
gene id: 7955:LOC101885301
uniprot id: A0A8M9Q0V4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:ano11
gene id: 7955:ano11
uniprot id: A0A8M3AYI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

7955:ict1
gene id: 7955:ict1
uniprot id: E7F0D0
names: Subcellular Location Annotation
messages: Mitochondrion

7955:camsap2a
gene id: 7955:camsap2a
uniprot id: A0A8M2BHT6
uniprot id: A0A8M2BHT9
uniprot id: A0A8M3AN06
uniprot id: A0A8M3B5I3
uniprot id: Q1LUF1
names: Domain
names: Similarity
messages: Belongs to the CAMSAP1 family.
messages: The CKK domain binds microtubules.

7955:mppe1
gene id: 7955:mppe1
uniprot id: A0A8M9P5W1
uniprot id: Q566Y9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallophosphoesterase superfamily. MPPE1 family.
messages: Binds 2 manganese ions per subunit.
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins (By similarity).
messages: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.
messages: cis-Golgi network membrane

7955:tm4sf4
gene id: 7955:tm4sf4
uniprot id: Q6DBQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

7955:rca2.2
gene id: 7955:rca2.2
uniprot id: A0A8N7TE76
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC103910054
gene id: 7955:LOC103910054
uniprot id: A0A8M9PKV3
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.

7955:pcyt1ba
gene id: 7955:pcyt1ba
uniprot id: A0A8M2B9I8
uniprot id: A0A8M9P5R2
uniprot id: A3KNL3
names: Function
names: Similarity
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.

7955:mettl14
gene id: 7955:mettl14
uniprot id: Q6NZ22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MT-A70-like family.
messages: Heterodimer; heterodimerizes with mettl3 to form an antiparallel heterodimer that constitutes an active methyltransferase. Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM. The MAC subcomplex is composed of mettl3 and mettl14.
messages: Nucleus
messages: The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with mettl3, mettl14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing.

7955:LOC100148704
gene id: 7955:LOC100148704
uniprot id: A0A8M1QL83
uniprot id: A0A8M3B2Y7
names: Similarity
messages: Belongs to the ARTD/PARP family.

7955:zgc:194209
gene id: 7955:zgc:194209
uniprot id: B3DIS2
names: Similarity
messages: Belongs to the strictosidine synthase family.

7955:LOC110438163
gene id: 7955:LOC110438163
uniprot id: A0A8M9P824
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

7955:unc5b
gene id: 7955:unc5b
uniprot id: A9JR35
uniprot id: F1QXJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

7955:fam189a2
gene id: 7955:fam189a2
uniprot id: A0A8M3AZY3
uniprot id: A0A8M3B2U4
names: Similarity
messages: Belongs to the ENTREP family.

7955:ramp2
gene id: 7955:ramp2
uniprot id: A0A8M6Z4W0
uniprot id: A9JR59
uniprot id: X1WDT6
names: Similarity
messages: Belongs to the RAMP family.

7955:si:dkey-26i13.5
gene id: 7955:si:dkey-26i13.5
uniprot id: A0A8M1Q1N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:lin54
gene id: 7955:lin54
uniprot id: A0A8M3B625
uniprot id: Q08CM4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lin-54 family.
messages: Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA.
messages: Component of the DREAM complex.
messages: Nucleus
messages: The CRC domain mediates DNA-binding. It contains two CXC subdomains (joined by a flexible linker) which are both required for efficient association with target DNA. Each CXC subdomain coordinates three Zn(2+) ions.

7955:zgc:173556
gene id: 7955:zgc:173556
uniprot id: A7MCA0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPC subfamily.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

7955:tmpob
gene id: 7955:tmpob
uniprot id: Q503J3
names: Similarity
messages: Belongs to the LEM family.

7955:mtus1a
gene id: 7955:mtus1a
uniprot id: A0JMQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MTUS1 family.
messages: Cell membrane
messages: Golgi apparatus
messages: Homodimer.
messages: May inhibit cell proliferation.
messages: Mitochondrion
messages: Nucleus

7955:vapa
gene id: 7955:vapa
uniprot id: A0A8M9P606
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:grin3bb
gene id: 7955:grin3bb
uniprot id: A0A8M6Z151
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

7955:cox18
gene id: 7955:cox18
uniprot id: A0A8M3AGY1
uniprot id: A0A8M9PZ05
uniprot id: A9JTC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

7955:c3b.1
gene id: 7955:c3b.1
uniprot id: A0A8M2BLB5
uniprot id: A0A8M3B5N7
uniprot id: A0A8M9PDW4
uniprot id: A5PMP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

7955:ube4b
gene id: 7955:ube4b
uniprot id: A0A8M9PKI9
uniprot id: F1Q5A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

7955:or109-3
gene id: 7955:or109-3
uniprot id: Q2PRK1
names: Subcellular Location Annotation
messages: Membrane

7955:tlx1
gene id: 7955:tlx1
uniprot id: Q8JI13
names: Subcellular Location Annotation
messages: Nucleus

7955:tsr1
gene id: 7955:tsr1
uniprot id: A0A0R4IKX4
uniprot id: E7FCX4
names: Subcellular Location Annotation
messages: nucleolus

7955:si:ch211-113e8.5
gene id: 7955:si:ch211-113e8.5
uniprot id: A0A2R8QU83
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:amotl2a
gene id: 7955:amotl2a
uniprot id: A1YB07
names: Developmental Stage
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the angiomotin family.
messages: Detected before the 1k-cell stage, suggesting that it is maternally supplied. At the sphere stage, stronger expression in the dorsal blastomeres. In the gastrula, expressed in the whole embryo, except in the evacuation zone. During segmentation and pharyngula period, expressed in many distinct domains, including the polster, telencephalon, trigeminal placodes, rhombomeres, trunk neurons, somites and axial vasculature. During the pharyngula period, additional expression observed in lateral line primordia and in intersegmental vessels.
messages: Interacts with SRC.
messages: Phosphorylation at Tyr-103 is necessary for efficient binding to SRC and synergistically functioning with SRC to activate the downstream MAPK pathway.
messages: Recycling endosome
messages: Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments and for cell movements during embryogenesis. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.
messages: Up-regulated by fgf17 and fgf8.

7955:erap1b
gene id: 7955:erap1b
uniprot id: A0A8M1PE71
uniprot id: A0A8M3B9L5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

7955:zgc:123238
gene id: 7955:zgc:123238
uniprot id: Q3B7P4
names: Function
names: Subcellular Location Annotation
messages: General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion

7955:gdf6a
gene id: 7955:gdf6a
uniprot id: P85857
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adults display microphthalmia, with eyes obscured by overgrown skin and misshapen irides. Mutants at 2 weeks of age show profound alterations in the morphology of individual photoreceptor subtypes and UV cones. At later timepoints loss of normal retinal lamination is observed, together with a disorganization of Mueller glia cells. Adults, cone photoreceptors are dysmorphic and reduced in abundance.
messages: Belongs to the TGF-beta family.
messages: Expressed both maternally and zygotically. Expressed from early cleavage stage until blastula sphere stage. Expression is then barely detectable until the end of gastrulation (tailbud stage) when expression is resumed.
messages: First expressed in late gastrula stage embryos (9.5 hours post fertilization (hpf)) in anterior neuroectoderm corresponding to the future dorsal part of the brain. Shortly after tailbud formation (11 hpf), expression expands to the entire neural region and is subsequently expressed in derivatives of the lateral neural plate and migrating neural crest cells, with the future midbrain and hindbrain showing strong expression. Also expressed weakly and transiently in the posterior embryo from 11.5 hpf to 15 hpf in the lateral mesoderm, and in ectoderm above the neural keel. At 14 hpf, expressed along the entire length of the embryo and starting around the 16-somite stage, expressed in the dorsal quadrant of the retina, representing the distal tip of the eye anlage. At this stage, also expressed in the hatching gland and the hypochord. At 24 hpf, expressed in the roof plate outlining the fourth brain ventricle, in the posterior hypochord, the primitive gut endoderm, the ventral tail mesenchyme, the dorsal part of the neural tube and the dorsal fin. Weakly expressed in the dorsal part of the posterior spinal cord and in blood cell precursors.
messages: Growth factor that controls proliferation and cellular differentiation in the retina. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Functions maternally in dorsal/ventral patterning to induce the expression of the zygotic bmp2b and bmp4 genes and ventralize embryos. Zygotic expression does not appear to regulate axis specification, but instead functions to establish the integrity of the axial vessels during embryonic development. May be involved in maintaining the identity of cells of the dorsal-most neural tube and of at least a subset of neural crest cells.
messages: Homodimer; disulfide-linked.
messages: Secreted

7955:aep1
gene id: 7955:aep1
uniprot id: Q5CZR5
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Homodimer in soluble form. Forms an octameric pore-like structure in the membrane.
messages: Pore-forming protein which might play a role in host defense. Exists as an antiparallel dimer in solution. Can also assemble into an octameric pore-like structure spanning the cell membrane. Oligomerization may be triggered by binding of the jacalin-type lectin domain to high-mannose cell-surface proteoglycans, and also requires a low pH environment. In vitro, shows high binding affinity for S.cerevisiae mannan and human HIV virus glycoprotein gp120.
messages: The jacalin-type lectin domain has strong affinity for high-mannose glycans with terminal non-reducing ends of Man(alpha-1,2)Man or Man(alpha-1,3)Man.
messages: Up-regulated in the presence of organophosphate pesticides and zinc.

7955:pabpc1l
gene id: 7955:pabpc1l
uniprot id: Q803E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

7955:gad1b
gene id: 7955:gad1b
uniprot id: A0A2R8QPB1
uniprot id: Q7ZUS3
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

7955:si:ch211-106h11.3
gene id: 7955:si:ch211-106h11.3
uniprot id: F1Q5N9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:paqr8
gene id: 7955:paqr8
uniprot id: Q801G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

7955:fam206a
gene id: 7955:fam206a
uniprot id: Q1LU93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABITRAM family.
messages: May regulate actin polymerization, filopodia dynamics and arborization of neurons.
messages: Nucleus
messages: Nucleus speckle
messages: dendrite
messages: growth cone
messages: lamellipodium

7955:mapre3b
gene id: 7955:mapre3b
uniprot id: A0A8M9Q0D6
uniprot id: Q6GMJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

7955:si:dkey-100n23.5
gene id: 7955:si:dkey-100n23.5
uniprot id: A0A8M1PYQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 5 family.
messages: Membrane

7955:arsa
gene id: 7955:arsa
uniprot id: A0A8M1N4V1
uniprot id: Q5BL32
names: Similarity
messages: Belongs to the sulfatase family.

7955:magt1
gene id: 7955:magt1
uniprot id: Q7ZV50
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory component of the STT3B-containing form of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. May be involved in substrate-specific N-glycosylation.
messages: Accessory component of the STT3B-containing form of the oligosaccharyltransferase (OST) complex.
messages: Belongs to the OST3/OST6 family.
messages: Cell membrane
messages: Cell surface magnesium transporter.
messages: Early developmental arrest.
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane

7955:hexb
gene id: 7955:hexb
uniprot id: A0A8M2BJ34
uniprot id: A0A8M3AZK9
uniprot id: A0A8M3B2G3
uniprot id: A2BHD8
uniprot id: F1QUU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

7955:si:ch1073-155h21.1
gene id: 7955:si:ch1073-155h21.1
uniprot id: F1QPB6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:hat1
gene id: 7955:hat1
uniprot id: Q66HU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.
messages: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac).

7955:si:dkey-160o24.3
gene id: 7955:si:dkey-160o24.3
uniprot id: E7FEV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:nrde2
gene id: 7955:nrde2
uniprot id: E7F365
names: Similarity
messages: Belongs to the NRDE2 family.

7955:trpc6b
gene id: 7955:trpc6b
uniprot id: A0A8M1RKV1
names: Subcellular Location Annotation
messages: Membrane

7955:npr1a
gene id: 7955:npr1a
uniprot id: Q1LX84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

7955:tbx21
gene id: 7955:tbx21
uniprot id: D1YT98
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7955:dlk2
gene id: 7955:dlk2
uniprot id: A0A8M3B4Z9
uniprot id: A0A8M3B7S7
uniprot id: A0A8M9PYA6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:pole
gene id: 7955:pole
uniprot id: B0V351
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: DNA polymerase II participates in chromosomal DNA replication.
messages: Nucleus

7955:pam
gene id: 7955:pam
uniprot id: A0A8M2B2D2
uniprot id: A0A8M3B606
uniprot id: A0A8M6Z0R0
names: Cofactor
names: Similarity
messages: Binds 2 Cu(2+) ions per subunit.
messages: Binds one Zn(2+) ion per subunit.
messages: In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.
messages: In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.

7955:si:ch211-203d1.3
gene id: 7955:si:ch211-203d1.3
uniprot id: A0A8M9PFM1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

7955:vtg4
gene id: 7955:vtg4
uniprot id: A0A8M1NAN4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:chrna9
gene id: 7955:chrna9
uniprot id: A0A8M9PKP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:myh9b
gene id: 7955:myh9b
uniprot id: A0A8M1QUS6
uniprot id: A0A8M2BB06
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:crp3
gene id: 7955:crp3
uniprot id: A3KPG5
uniprot id: A8KBB1
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:sco2
gene id: 7955:sco2
uniprot id: Q5RH02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCO1/2 family.
messages: Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2.
messages: Homodimer.
messages: Mitochondrion inner membrane

7955:rras2
gene id: 7955:rras2
uniprot id: Q568M0
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

7955:si:zfos-323e3.4
gene id: 7955:si:zfos-323e3.4
uniprot id: E7FB32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

7955:invs
gene id: 7955:invs
uniprot id: Q8UVC1
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds calmodulin via its IQ domains.
messages: Cytoplasm
messages: Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling.
messages: The D-box (destruction box) mediate the interaction with APC proteins, and may act as a recognition signal for degradation via the ubiquitin-proteasome pathway.
messages: cytoskeleton

7955:taar19d
gene id: 7955:taar19d
uniprot id: A0A0R4IEE2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:LOC100330028
gene id: 7955:LOC100330028
uniprot id: A0A8M6Z388
uniprot id: A0A8M9PSF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

7955:fabp10a
gene id: 7955:fabp10a
uniprot id: B2GQZ3
uniprot id: Q9I8L5
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A member of the basic liver-type FABPs, which are only found, thus far, in non-mammalian vertebrates.
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Binds hydrophobic ligands, such as cholate, in the cytoplasm. May be involved in intracellular lipid transport (By similarity). Binds one cholate per subunit.
messages: Cytoplasm
messages: Expressed in the developing embryonic liver from 48 hpf. Also expressed in the liver of 5-day-old larvae. In adults, primarily expressed in the liver, with weak expression in the testis and intestine.
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
messages: PubMed:12633865 reports expression in the ventral endoderm at 36 hpf, whereas PubMed:16857010 does not detect expression this early. The different timings may reflect strain-specific differences.

7955:apoa1bp
gene id: 7955:apoa1bp
uniprot id: Q6DHK1
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homodimer (By similarity). Interacts with APOA1 (PubMed:23719382). Binds to HDL (PubMed:23719382).
messages: Mitochondrion
messages: Mutants do not show increased levels of free (unesterified) cholesterol.
messages: Secreted

7955:grm6b
gene id: 7955:grm6b
uniprot id: A1L1T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

7955:kat6b
gene id: 7955:kat6b
uniprot id: A0A8M3AZ79
uniprot id: A0A8M3B5C9
uniprot id: A0A8M3B851
uniprot id: A0A8M3BER5
names: Similarity
messages: Belongs to the MYST (SAS/MOZ) family.

7955:st3gal4
gene id: 7955:st3gal4
uniprot id: A2RUW6
uniprot id: Q6KB53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

7955:LOC100330746
gene id: 7955:LOC100330746
uniprot id: Q6PC28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 7B2 family.
messages: Secreted

7955:efhc2
gene id: 7955:efhc2
uniprot id: A0A8M3AW60
uniprot id: B8A5Q4
names: Subcellular Location Annotation
messages: cilium axoneme

7955:ptpn13
gene id: 7955:ptpn13
uniprot id: A0A0R4IPR0
uniprot id: A0A0R4IWH3
uniprot id: A0A8M2B8N1
uniprot id: A0A8M3AL92
uniprot id: A0A8M3ALY6
uniprot id: A0A8M3ATM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: Regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.
messages: cytoskeleton

7955:cx39.4
gene id: 7955:cx39.4
uniprot id: Q1LWG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

7955:rnft2
gene id: 7955:rnft2
uniprot id: A0A8M2BCC1
uniprot id: Q504D2
names: Subcellular Location Annotation
messages: Membrane

7955:gpr137ba
gene id: 7955:gpr137ba
uniprot id: E7F594
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts also as a negative regulator of osteoclast activity (PubMed:31173907). May be involved in interleukin-4-induced M2 macrophage polarization (By similarity).
messages: Belongs to the GPR137 family.
messages: Knockout zebrafish are viable and fertile and display no obvious morphological defects as adults (PubMed:31173907, PubMed:31036939). However deficient zebrafish have abnormal microglial with expended lysosomes (PubMed:31036939). They also display increased bone resorption (PubMed:31173907).
messages: Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (By similarity). Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome (PubMed:31036939). Acts also as a negative regulator of osteoclast activity (PubMed:31173907). May be involved in interleukin-4-induced M2 macrophage polarization (By similarity).
messages: Lysosome membrane

7955:arhgef3l
gene id: 7955:arhgef3l
uniprot id: A0A8M2B8W3
uniprot id: Q504F6
names: Function
names: Subcellular Location Annotation
messages: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
messages: Cytoplasm

7955:pyyb
gene id: 7955:pyyb
uniprot id: E7F0L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

7955:LOC100004180
gene id: 7955:LOC100004180
uniprot id: A0A2R8QDW2
names: Subcellular Location Annotation
messages: Membrane

7955:trpm4a
gene id: 7955:trpm4a
uniprot id: A0A8M2BB87
uniprot id: A0A8M9PCR1
uniprot id: S5TRY1
names: Subcellular Location Annotation
messages: Membrane

7955:tbx4
gene id: 7955:tbx4
uniprot id: F1R688
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7955:pde4bb
gene id: 7955:pde4bb
uniprot id: A0A8M3APY5
uniprot id: A0A8M9PPR9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

7955:LOC407643
gene id: 7955:LOC407643
uniprot id: A0A8M9PLG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

7955:gabrb4
gene id: 7955:gabrb4
uniprot id: A0A2R8QJR5
uniprot id: F1Q4Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:tmem163a
gene id: 7955:tmem163a
uniprot id: A0A8M2BF29
uniprot id: B0UY98
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: At 24 hours post-fertilization (hpf), it is mainly expressed in the central nervous system and Rohon-Beard sensory neurons. It is detected in the brain and motor neurons of the spinal cord at 48 hpf.
messages: Belongs to the TMEM163 family.
messages: Cell membrane
messages: Early endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Morpholino tmem163a knockdown severely affects central nervous system development. Morphant larvae display locomotor disability, decreased survival, and myelin deficits associated with a reduced number of oligodendrocytes.
messages: Zinc ion transporter that mediates zinc efflux and plays a crucial role in intracellular zinc homeostasis (By similarity). Binds the divalent cations Zn(2+), Ni(2+), and to a minor extent Cu(2+) (By similarity). Is a functional modulator of P2X purinoceptors, including P2RX1, P2RX3, P2RX4 and P2RX7 (By similarity). Plays a role in central nervous system development and is required for myelination, and survival and proliferation of oligodendrocytes (PubMed:35455965).
messages: synaptic vesicle membrane

7955:tmem106bb
gene id: 7955:tmem106bb
uniprot id: Z4YHQ6
names: Similarity
messages: Belongs to the TMEM106 family.

7955:myrfl
gene id: 7955:myrfl
uniprot id: A0A8M1RS78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRF family.
messages: Membrane

7955:plxna3
gene id: 7955:plxna3
uniprot id: A0A8M3AUY1
uniprot id: B0S5N4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Coreceptor for class 3 semaphorins. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
messages: Detected in primary motor neurons in the embryonic nervous system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:hagh
gene id: 7955:hagh
uniprot id: A0A8M9PEU7
uniprot id: Q6P963
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Only one single gene encoding glyoxalase II has been identified in vertebrates. In yeast and higher plants, separate genes encode the cytosolic and mitochondrial forms of glyoxalase II.
messages: Produced by alternative initiation at Met-44 of isoform 1. Alternative initiation has been proven in human.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

7955:mgst1.1
gene id: 7955:mgst1.1
uniprot id: Q5XJJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

7955:LOC100334689
gene id: 7955:LOC100334689
uniprot id: E7FEG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

7955:slc19a3a
gene id: 7955:slc19a3a
uniprot id: E7F6V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Membrane

7955:hspb15
gene id: 7955:hspb15
uniprot id: A5JV84
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

7955:aurka
gene id: 7955:aurka
uniprot id: Q6DBZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centrosome

7955:strip2
gene id: 7955:strip2
uniprot id: A0A8M9PI62
uniprot id: E7F9X6
uniprot id: X1WE96
names: Similarity
messages: Belongs to the STRIP family.

7955:ghrhrb
gene id: 7955:ghrhrb
uniprot id: A0A8M9Q130
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

7955:myo1hb
gene id: 7955:myo1hb
uniprot id: A0A8M3B2M0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:steap2
gene id: 7955:steap2
uniprot id: A0A8M9PUK4
uniprot id: A0A8M9PY20
uniprot id: E7FFL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

7955:cxcl8b.3
gene id: 7955:cxcl8b.3
uniprot id: A9ZPF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

7955:lgi3
gene id: 7955:lgi3
uniprot id: Q2HPG0
names: Subcellular Location Annotation
messages: Secreted

7955:si:dkey-125e8.4
gene id: 7955:si:dkey-125e8.4
uniprot id: A0A8M6Z7H8
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:dbx1a
gene id: 7955:dbx1a
uniprot id: B2GNV2
uniprot id: Q9PTU1
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the H2.0 homeobox family.
messages: Detected at 6-7 hours post-fertilization (hpf). Levels increase after 10 hpf and highest expression is seen at 24 hpf.
messages: Nucleus

7955:psmc1a
gene id: 7955:psmc1a
uniprot id: Q7ZWD1
names: Similarity
messages: Belongs to the AAA ATPase family.

7955:oprl1
gene id: 7955:oprl1
uniprot id: A0A0R4IZH2
uniprot id: A0A8M1P286
uniprot id: Q7T3Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
messages: Membrane
messages: Vesicle

7955:kctd13
gene id: 7955:kctd13
uniprot id: A9ULR9
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: According to a first report, morpholino-mediated knockdown of kctd13 leads to increased brain size and cell proliferation (PubMed:22596160). However, it was later shown that deletion of kctd13 does not cause any change in brain size or cell proliferation (PubMed:29088697). Experimental conditions used may explain discrepancies. A possible explanation being that morpholinos used in the first study, may have affected off-targets.
messages: Belongs to the BACURD family.
messages: Increased levels of RHOA. N ochange in brain size or neural progenitor cell proliferation is observed.
messages: Nucleus
messages: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission (By similarity). The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and promoting synaptic transmission (PubMed:29088697).

7955:ino80db
gene id: 7955:ino80db
uniprot id: A0A8M3AT77
uniprot id: A1L1F6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the INO80D family.
messages: Component of the chromatin-remodeling INO80 complex.
messages: Nucleus
messages: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

7955:ckap5
gene id: 7955:ckap5
uniprot id: A0A0R4IA93
uniprot id: A0A0R4IQI9
uniprot id: A0A8M3AP08
uniprot id: A0A8M3B733
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOG/XMAP215 family.
messages: kinetochore

7955:p2ry4
gene id: 7955:p2ry4
uniprot id: A0A8M2BL13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:snx21
gene id: 7955:snx21
uniprot id: Q08BL4
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Membrane

7955:aebp2
gene id: 7955:aebp2
uniprot id: Q7SXV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AEBP2/jing C2H2-type zinc-finger family.
messages: DNA-binding transcriptional repressor. May interact with and stimulate the activity of histone methyltransferase complexes.
messages: Nucleus

7955:thumpd3
gene id: 7955:thumpd3
uniprot id: A3KP95
uniprot id: E9QJ61
names: Similarity
messages: Belongs to the methyltransferase superfamily.

7955:slc45a3
gene id: 7955:slc45a3
uniprot id: A4QP56
names: Subcellular Location Annotation
messages: Membrane

7955:LOC100331306
gene id: 7955:LOC100331306
uniprot id: A0A8M1RKL8
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:si:dkey-185m8.2
gene id: 7955:si:dkey-185m8.2
uniprot id: A0A0G2L7C5
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:LOC100333734
gene id: 7955:LOC100333734
uniprot id: A0A8M2BGX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

7955:sema3fb
gene id: 7955:sema3fb
uniprot id: A0A2R8Q5T8
uniprot id: E7F6C0
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:fshb
gene id: 7955:fshb
uniprot id: Q6TCF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

7955:itgae.2
gene id: 7955:itgae.2
uniprot id: A0A8M1RMI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

7955:or115-2
gene id: 7955:or115-2
uniprot id: Q2PRH6
names: Subcellular Location Annotation
messages: Membrane

7955:tmem254
gene id: 7955:tmem254
uniprot id: Q7T380
names: Subcellular Location Annotation
messages: Membrane

7955:si:ch211-149k23.9
gene id: 7955:si:ch211-149k23.9
uniprot id: A0A8M9PC40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

7955:stra6l
gene id: 7955:stra6l
uniprot id: A0A8M2B6K3
uniprot id: A3KP50
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:slc25a13
gene id: 7955:slc25a13
uniprot id: A0A8M9PNN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

7955:minpp1a
gene id: 7955:minpp1a
uniprot id: A0A8M2B5D6
uniprot id: Q08CJ4
names: Similarity
messages: Belongs to the histidine acid phosphatase family. MINPP1 subfamily.

7955:zgc:198419
gene id: 7955:zgc:198419
uniprot id: A8WGK2
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

7955:ponzr5
gene id: 7955:ponzr5
uniprot id: E9QD19
names: Similarity
messages: Belongs to the cornifelin family.

7955:sh3gl1a
gene id: 7955:sh3gl1a
uniprot id: A0A8M2BFR0
uniprot id: Q1MT71
uniprot id: Q7ZWA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

7955:zmp:0000000936
gene id: 7955:zmp:0000000936
uniprot id: E7F5V6
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

7955:ube2l3a
gene id: 7955:ube2l3a
uniprot id: Q6IQK2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7955:cxcl11.8
gene id: 7955:cxcl11.8
uniprot id: A2BHJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

7955:klc1a
gene id: 7955:klc1a
uniprot id: A0A8M2B2P5
uniprot id: A0A8M2B2S3
uniprot id: A0A8M2B3J0
uniprot id: A0A8M3AYZ1
uniprot id: F1QS14
uniprot id: Q7SXI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

7955:rap2b
gene id: 7955:rap2b
uniprot id: Q7SY59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Recycling endosome membrane

7955:homer2
gene id: 7955:homer2
uniprot id: Q502P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

7955:coro1a
gene id: 7955:coro1a
uniprot id: Q7SX58
names: Similarity
messages: Belongs to the WD repeat coronin family.

7955:si:dkey-73p2.1
gene id: 7955:si:dkey-73p2.1
uniprot id: F1Q8X3
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:rin2
gene id: 7955:rin2
uniprot id: E7F662
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

7955:si:ch211-207g17.3
gene id: 7955:si:ch211-207g17.3
uniprot id: F1QYD4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:tigarb
gene id: 7955:tigarb
uniprot id: Q7ZVE3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoglycerate mutase family.
messages: Cytoplasm
messages: Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. May play a role in mitophagy inhibition.
messages: Mitochondrion
messages: Not expected to have any kinase activity.
messages: Nucleus

7955:cysltr1
gene id: 7955:cysltr1
uniprot id: Q502K5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:gria2a
gene id: 7955:gria2a
uniprot id: A0A8M2BI34
uniprot id: A0A8M2BI57
uniprot id: A0A8M2BIL5
uniprot id: Q71E63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

7955:znrf1
gene id: 7955:znrf1
uniprot id: Q6P4U6
names: Domain
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase that plays a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity.
messages: Endosome
messages: Lysosome
messages: Membrane
messages: The RING-type zinc finger domain is required for E3 ligase activity.

7955:tradd
gene id: 7955:tradd
uniprot id: B2GNQ4
uniprot id: Q9I9N5
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter molecule for tnfrsf1a that specifically associates with the cytoplasmic domain of activated tnfrsf1a mediating its interaction with fadd.
messages: Cytoplasm
messages: Heterodimer with tnfrsf1a.
messages: Nucleus
messages: Requires the intact death domain to associate with tnfrsf1a.
messages: cytoskeleton

7955:gpr107
gene id: 7955:gpr107
uniprot id: A0A8M3ASE9
uniprot id: A0A8M9Q3Q5
uniprot id: A0JMH7
names: Subcellular Location Annotation
messages: Membrane

7955:g6pca.2
gene id: 7955:g6pca.2
uniprot id: A2VD27
uniprot id: F1QHF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

7955:tspan5a
gene id: 7955:tspan5a
uniprot id: Q5XJE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7955:tmem131
gene id: 7955:tmem131
uniprot id: A0A8M9PMV5
uniprot id: A0A8M9QB17
names: Similarity
messages: Belongs to the TMEM131 family.

7955:hoxb13a
gene id: 7955:hoxb13a
uniprot id: Q1ECY2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: At 24 hours post-fertilization, expression is restricted to the tip of the developing tail.
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

7955:adcyap1a
gene id: 7955:adcyap1a
uniprot id: Q5XJ29
uniprot id: Q9DE29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

7955:apoob
gene id: 7955:apoob
uniprot id: Q5XJ26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

7955:gon4l
gene id: 7955:gon4l
uniprot id: F1QI87
names: Subcellular Location Annotation
messages: Nucleus

7955:si:dkey-14d8.6
gene id: 7955:si:dkey-14d8.6
uniprot id: Q5RHW2
names: Similarity
messages: Belongs to the dermatopontin family.

7955:svila
gene id: 7955:svila
uniprot id: A0A8M9PW23
uniprot id: A0A8M9Q864
uniprot id: A0A8M9QE30
uniprot id: A0A8M9QII8
uniprot id: A0A8M9QIJ4
uniprot id: A0A8M9QMC6
uniprot id: F1Q6K8
uniprot id: Q38HW9
names: Similarity
messages: Belongs to the villin/gelsolin family.

7955:serpinb1l3
gene id: 7955:serpinb1l3
uniprot id: A0A8M2BLG1
uniprot id: Q7T309
names: Similarity
messages: Belongs to the serpin family.

7955:eif3hb
gene id: 7955:eif3hb
uniprot id: Q5PR67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

7955:erbb4b
gene id: 7955:erbb4b
uniprot id: A0A8M3BCL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

7955:snapin
gene id: 7955:snapin
uniprot id: Q1L8R9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAPIN family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.
messages: synaptic vesicle membrane

7955:eno4
gene id: 7955:eno4
uniprot id: A0A8M2B540
uniprot id: A0A8M9P064
uniprot id: Q08BC6
names: Caution
names: Similarity
messages: Although it is highly related to enolase enzyme family, lacks the conserved Glu active site.
messages: Belongs to the enolase family.

7955:clrn2
gene id: 7955:clrn2
uniprot id: B8A5K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

7955:itga9
gene id: 7955:itga9
uniprot id: A0A8M9QFA5
uniprot id: F1Q8T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

7955:psma1
gene id: 7955:psma1
uniprot id: Q6DGX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

7955:tars2
gene id: 7955:tars2
uniprot id: A0A8M9PJQ9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

7955:sptssa
gene id: 7955:sptssa
uniprot id: Q5BJC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPTSS family. SPTSSA subfamily.
messages: Component of the serine palmitoyltransferase (SPT) complex, which is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. The heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core of the enzyme, while SPTSSA or SPTSSB subunits determine substrate specificity. SPT also interacts with ORMDL proteins, especially ORMDL3, which negatively regulate SPT activity in the presence of ceramides.
messages: Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. Within the SPT complex, SPTSSA stimulates the catalytic activity and plays a role in substrate specificity, which depends upon the overall complex composition. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. Independently of its action as a SPT component, may be involved in MBOAT7 localization to mitochondria-associated membranes, a membrane bridge between the endoplasmic reticulum and mitochondria, may hence affect MBOAT7-catalyzed incorporation of arachidonic acid into phosphatidylinositol.
messages: Endoplasmic reticulum membrane

7955:fus
gene id: 7955:fus
uniprot id: F1R0M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

7955:dhrs7ca
gene id: 7955:dhrs7ca
uniprot id: Q5BL28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Putative oxidoreductase.
messages: Secreted

7955:actc1a
gene id: 7955:actc1a
uniprot id: Q6IQR3
names: Similarity
messages: Belongs to the actin family.

7955:appl1
gene id: 7955:appl1
uniprot id: A0A8M9PV15
uniprot id: B2XCL9
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: Nucleus
messages: phagosome
messages: ruffle

7955:daxx
gene id: 7955:daxx
uniprot id: A0A8M2B6F2
uniprot id: A0A8M6YWD7
uniprot id: Q1LUU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAXX family.
messages: Cytoplasm
messages: PML body
messages: centromere
messages: nucleolus
messages: nucleoplasm

7955:tec
gene id: 7955:tec
uniprot id: A9ULT3
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

7955:mul1a
gene id: 7955:mul1a
uniprot id: Q5M7X9
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
messages: Homooligomer.
messages: Mitochondrion outer membrane
messages: The zinc finger domain is required for E3 ligase activity.

7955:si:dkey-237h12.3
gene id: 7955:si:dkey-237h12.3
uniprot id: A0A8M9QGV6
uniprot id: A0A8M9QPK0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:cops4
gene id: 7955:cops4
uniprot id: A0A2R8QL66
uniprot id: Q6P0H6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN4 family.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity).
messages: Component of the CSN complex, probably composed of cops1, cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
messages: Cytoplasm
messages: Nucleus
messages: Vesicle
messages: synaptic vesicle

7955:cst14a.1
gene id: 7955:cst14a.1
uniprot id: E7EYW5
names: Similarity
messages: Belongs to the cystatin family.

7955:pnpo
gene id: 7955:pnpo
uniprot id: A0A8M1P3D4
names: Function
names: Similarity
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).

7955:slc29a4
gene id: 7955:slc29a4
uniprot id: A0A8M2BBN6
uniprot id: A1L272
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine (By similarity).
messages: Membrane

7955:LOC792450
gene id: 7955:LOC792450
uniprot id: A0A8M9PSA1
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:sema6dl
gene id: 7955:sema6dl
uniprot id: A0A8M2BKW9
uniprot id: A0A8M2BLA1
uniprot id: A0A8M3AV35
uniprot id: A3KPS3
uniprot id: A3KPS4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:zmat5
gene id: 7955:zmat5
uniprot id: Q6AXL8
names: Subcellular Location Annotation
names: Subunit
messages: Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.
messages: Nucleus

7955:LOC799834
gene id: 7955:LOC799834
uniprot id: A0A8M9PQU3
names: Similarity
messages: Belongs to the peptidase S1C family.

7955:LOC101885707
gene id: 7955:LOC101885707
uniprot id: A0A8M9Q334
names: Similarity
messages: Belongs to the apolipoprotein L family.

7955:LOC110438176
gene id: 7955:LOC110438176
uniprot id: A0A8M9PPW9
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:LOC103908824
gene id: 7955:LOC103908824
uniprot id: A0A8M9NYH7
uniprot id: A0A8M9P744
uniprot id: A0A8M9PIF9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:gpc2
gene id: 7955:gpc2
uniprot id: V5NF87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

7955:dlgap5
gene id: 7955:dlgap5
uniprot id: A0A8M2BGU9
uniprot id: Q66HZ9
names: Similarity
messages: Belongs to the SAPAP family.

7955:sphkap
gene id: 7955:sphkap
uniprot id: Q1LV19
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II).
messages: Belongs to the AKAP110 family.
messages: Cytoplasm
messages: RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

7955:zgc:154045
gene id: 7955:zgc:154045
uniprot id: Q08BX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cleavage furrow
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: trans-Golgi network

7955:plekho1a
gene id: 7955:plekho1a
uniprot id: A4IG55
names: Function
names: PTM
names: Subcellular Location Annotation
messages: C-terminal fragments could be released during apoptosis via caspase-3-dependent cleavage.
messages: Cytoplasm
messages: Membrane
messages: Nucleus
messages: Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP).

7955:nfe2l2a
gene id: 7955:nfe2l2a
uniprot id: A0A8M2BJQ0
uniprot id: Q8JIM1
names: Similarity
messages: Belongs to the bZIP family. CNC subfamily.

7955:cept1b
gene id: 7955:cept1b
uniprot id: A0A8M3B557
uniprot id: A0A8M9PRW3
uniprot id: A7MBY6
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

7955:zgc:153760
gene id: 7955:zgc:153760
uniprot id: F1QTX6
uniprot id: Q08C20
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

7955:sh3gl2a
gene id: 7955:sh3gl2a
uniprot id: Q803T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

7955:flnca
gene id: 7955:flnca
uniprot id: A0A0R4IUS4
uniprot id: A0A8M6YYI5
names: Similarity
messages: Belongs to the filamin family.

7955:gucy2c
gene id: 7955:gucy2c
uniprot id: A0A8M3AQ67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

7955:flvcr2b
gene id: 7955:flvcr2b
uniprot id: A0A8M2B829
uniprot id: E9QH04
names: Subcellular Location Annotation
messages: Membrane

7955:aig1
gene id: 7955:aig1
uniprot id: A0A8M3ATE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

7955:eif4a1b
gene id: 7955:eif4a1b
uniprot id: Q7ZU67
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

7955:duox
gene id: 7955:duox
uniprot id: A0A8M6YYK2
uniprot id: A0A8M9P6X2
uniprot id: A0A8M9PVM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
messages: In the N-terminal section; belongs to the peroxidase family.
messages: Membrane

7955:LOC100002960
gene id: 7955:LOC100002960
uniprot id: A0A8M1NXF2
uniprot id: A0A8M3APF5
uniprot id: A0A8M9QH15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

7955:hyal2b
gene id: 7955:hyal2b
uniprot id: A0A8M2BLB2
uniprot id: A0A8N7TES9
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

7955:zgc:175066
gene id: 7955:zgc:175066
uniprot id: A9JTF4
names: Similarity
messages: Belongs to the FAM53 family.

7955:ube2ka
gene id: 7955:ube2ka
uniprot id: Q5BLA9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7955:LOC110437843
gene id: 7955:LOC110437843
uniprot id: A0A8M9PUV9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:acat1
gene id: 7955:acat1
uniprot id: Q6AZA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Homotetramer.
messages: Mitochondrion
messages: This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism.

7955:jpt2
gene id: 7955:jpt2
uniprot id: F1Q6E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

7955:si:ch73-160i9.3
gene id: 7955:si:ch73-160i9.3
uniprot id: A0A8M1Q180
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

7955:sybu
gene id: 7955:sybu
uniprot id: A0A8M2B4L2
uniprot id: D3KVM2
uniprot id: Q08CJ9
names: Subcellular Location Annotation
messages: Membrane

7955:pcyt1aa
gene id: 7955:pcyt1aa
uniprot id: A0A8M9Q8R8
uniprot id: Q568K8
names: Function
names: Similarity
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.

7955:katna1
gene id: 7955:katna1
uniprot id: A0A8M9PHA7
uniprot id: Q5RII9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with katnb1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with katnb1, which may serve as a targeting subunit.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
messages: Cytoplasm
messages: centrosome
messages: spindle
messages: spindle pole

7955:vamp8
gene id: 7955:vamp8
uniprot id: Q7ZUC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

7955:si:dkey-239j18.2
gene id: 7955:si:dkey-239j18.2
uniprot id: E9QBE2
names: Similarity
messages: Belongs to the peptidase C1 family.

7955:smfn
gene id: 7955:smfn
uniprot id: F1QNX9
names: Similarity
messages: Belongs to the oligoribonuclease family.

7955:wasf1
gene id: 7955:wasf1
uniprot id: A0A8M1Q749
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

7955:snx10b
gene id: 7955:snx10b
uniprot id: A8WG21
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasm
messages: Endosome membrane
messages: Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes.
messages: The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.

7955:gdf5
gene id: 7955:gdf5
uniprot id: F1QK08
names: Similarity
messages: Belongs to the TGF-beta family.

7955:gpx4b
gene id: 7955:gpx4b
uniprot id: A0A8M1N743
uniprot id: B5DDU3
names: Similarity
messages: Belongs to the glutathione peroxidase family.

7955:sestd1
gene id: 7955:sestd1
uniprot id: Q7SX85
names: Function
names: Similarity
messages: Belongs to the SOLO family.
messages: May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels trpc4 and trpc5. Binds phospholipids (By similarity).

7955:plcg1
gene id: 7955:plcg1
uniprot id: Q804J6
names: Function
messages: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

7955:tlr22
gene id: 7955:tlr22
uniprot id: A0A2R8RTN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

7955:tas1r3
gene id: 7955:tas1r3
uniprot id: Q2MHK9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:LOC103911968
gene id: 7955:LOC103911968
uniprot id: A0A8M3B4Y0
names: Similarity
messages: Belongs to the poly(ADP-ribose) glycohydrolase family.

7955:zgc:86709
gene id: 7955:zgc:86709
uniprot id: Q6IQL9
names: Similarity
messages: Belongs to the actin family.

7955:sesn2
gene id: 7955:sesn2
uniprot id: A0F081
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

7955:sfmbt2
gene id: 7955:sfmbt2
uniprot id: A0A8M2BC60
uniprot id: A0A8N7UQL5
names: Subcellular Location Annotation
messages: Nucleus

7955:hcrt
gene id: 7955:hcrt
uniprot id: Q0PIA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the orexin family.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum
messages: Synapse
messages: Vesicle

7955:fam83ha
gene id: 7955:fam83ha
uniprot id: F1R9L2
names: Similarity
messages: Belongs to the FAM83 family.

7955:gss
gene id: 7955:gss
uniprot id: F1RC64
uniprot id: Q5XJT8
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

7955:cog6
gene id: 7955:cog6
uniprot id: A0A0R4IS45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG6 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane
messages: Required for normal Golgi function.

7955:tbca
gene id: 7955:tbca
uniprot id: Q7ZV25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
messages: cytoskeleton

7955:rtn3
gene id: 7955:rtn3
uniprot id: A0A8M9PNQ3
uniprot id: Q4G5W3
uniprot id: Q7ZUD6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:ltk
gene id: 7955:ltk
uniprot id: F1QVU0
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Complete absence of iridophores (PubMed:29078341, PubMed:29317532). Fishes do not survive past 6 days post-fertilization (dpf), possibly because the swim bladder cannot fill with air (PubMed:29317532).
messages: Expressed in notochord from 18-24 hours post-fertilization (hpf) and prominently in brain and swim bladder from 3 days post-fertilization (dpf).
messages: Homodimer; homodimerizes upon binding to alkal ligands (alkal1, alkal2a or alkal2b).
messages: Inhibited by ALK inhibitor TAE684.
messages: Mainly expressed in neural crest cells (NCCs) and iridophores (PubMed:18369445, PubMed:29317532). In adults, expressed in the head and iridophores of the trunk and eyes, as well as in the swim bladder (PubMed:29317532).
messages: Receptor tyrosine kinase required for the establishment and proliferation of iridophores and their progenitors from multipotent neural crest cells (PubMed:18369445, PubMed:23821036, PubMed:26801003, PubMed:29078341, PubMed:29317532). Iridophores are the blue-tinted cells that reflect light to give fish their metallic shine and which, together with yellow xanthophore and black melanophores, generate the zebrafish's stripes (PubMed:18369445, PubMed:23821036, PubMed:26801003). Following activation by alkal ligands (alkal1, alkal2a or alkal2b) at the cell surface, transduces an extracellular signal into an intracellular response (PubMed:29078341, PubMed:29317532). Ligand-binding to the extracellular domain induces tyrosine kinase activation, resulting in the activation of the mitogen-activated protein kinase (MAPK) pathway (By similarity). Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif (By similarity).

7955:ap4b1
gene id: 7955:ap4b1
uniprot id: A0A8M3AUZ7
uniprot id: Q7T3G3
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

7955:ppa1a
gene id: 7955:ppa1a
uniprot id: Q6PC11
names: Similarity
messages: Belongs to the PPase family.

7955:zgc:165518
gene id: 7955:zgc:165518
uniprot id: F1QIP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

7955:si:ch211-79m20.1
gene id: 7955:si:ch211-79m20.1
uniprot id: A0A8M9Q3E7
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

7955:LOC101882351
gene id: 7955:LOC101882351
uniprot id: A0A8M9P4H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

7955:gng7
gene id: 7955:gng7
uniprot id: Q6DGZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

7955:foxa
gene id: 7955:foxa
uniprot id: A0A0R4IHN9
uniprot id: F1QC30
names: Subcellular Location Annotation
messages: Nucleus

7955:dennd6b
gene id: 7955:dennd6b
uniprot id: A0A8M2BBU9
uniprot id: Q803T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND6 family.
messages: Recycling endosome

7955:l3mbtl1b
gene id: 7955:l3mbtl1b
uniprot id: A0A8M3AQL9
uniprot id: E9QEX7
names: Subcellular Location Annotation
messages: Nucleus

7955:ntrk2a
gene id: 7955:ntrk2a
uniprot id: A0A8M3AVL1
uniprot id: A0A8M3B589
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

7955:pik3ca
gene id: 7955:pik3ca
uniprot id: F1QAD7
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

7955:nt5dc1
gene id: 7955:nt5dc1
uniprot id: A0A8M9PHH6
uniprot id: A7MBY0
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

7955:adgrg11
gene id: 7955:adgrg11
uniprot id: F1R9B1
names: Subcellular Location Annotation
messages: Membrane

7955:zranb1a
gene id: 7955:zranb1a
uniprot id: A0A8M3BED9
names: Similarity
messages: Belongs to the peptidase C64 family.

7955:slc37a4b
gene id: 7955:slc37a4b
uniprot id: F1QPV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

7955:cmc2
gene id: 7955:cmc2
uniprot id: Q6DHJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: May be involved in cytochrome c oxidase biogenesis.
messages: Mitochondrion

7955:si:dkey-183i3.9
gene id: 7955:si:dkey-183i3.9
uniprot id: A0A0R4IYS6
names: Subcellular Location Annotation
messages: Membrane

7955:pou3f2a
gene id: 7955:pou3f2a
uniprot id: A2VD21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus

7955:wnk4b
gene id: 7955:wnk4b
uniprot id: A0A2R8QPF3
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

7955:si:ch73-233k15.2
gene id: 7955:si:ch73-233k15.2
uniprot id: I3ISX5
names: Similarity
messages: Belongs to the apolipoprotein L family.

7955:med11
gene id: 7955:med11
uniprot id: A3KNK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

7955:kat7b
gene id: 7955:kat7b
uniprot id: A0A8M9QIK1
uniprot id: Q7ZW29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

7955:LOC100331412
gene id: 7955:LOC100331412
uniprot id: A3KPR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:ube2d2
gene id: 7955:ube2d2
uniprot id: Q7ZUK1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7955:phyhd1
gene id: 7955:phyhd1
uniprot id: Q5U3U0
names: Function
names: Similarity
messages: 2-oxoglutarate(2OG)-dependent dioxygenase that catalyzes the conversion of 2-oxoglutarate to succinate and CO(2) in an iron-dependent manner. However, does not couple 2OG turnover to the hydroxylation of acyl-coenzyme A derivatives, implying that it is not directly involved in phytanoyl coenzyme-A metabolism. Does not show detectable activity towards fatty acid CoA thioesters.
messages: Belongs to the PhyH family. PHYHD1 subfamily.

7955:zgc:101559
gene id: 7955:zgc:101559
uniprot id: Q5U3W4
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

7955:slc26a4
gene id: 7955:slc26a4
uniprot id: A0A8M6Z5Y9
uniprot id: C8XTB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sodium-independent transporter of chloride and iodide.

7955:pdlim7
gene id: 7955:pdlim7
uniprot id: Q6P7E4
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Anchored to cell periphery via its N-terminal PDZ domain.
messages: May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues (By similarity).
messages: The LIM zinc-binding 3 (LIM 3) domain provides the structural basis for recognition of tyrosine-containing tight turn structures.
messages: cytoskeleton

7955:cyp21a2
gene id: 7955:cyp21a2
uniprot id: A0A8M9NZM6
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:poc1a
gene id: 7955:poc1a
uniprot id: Q7ZVF0
names: Function
names: Similarity
messages: Belongs to the WD repeat POC1 family.
messages: May play an important role in centriole assembly and/or stability and ciliogenesis.

7955:mettl21a
gene id: 7955:mettl21a
uniprot id: Q5BLD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. METTL21 family.
messages: Cytoplasm
messages: Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members.

7955:lhfpl2a
gene id: 7955:lhfpl2a
uniprot id: A0A8M9P387
uniprot id: Q6P0C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LHFP family.
messages: Membrane
messages: Plays a role in fertility. Involved in distal reproductive tract development.

7955:mrpl35
gene id: 7955:mrpl35
uniprot id: Q0D286
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Mitochondrion

7955:acad9
gene id: 7955:acad9
uniprot id: Q1ED16
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

7955:rab3gap2
gene id: 7955:rab3gap2
uniprot id: A0A8M6YTS4
uniprot id: K7DYN0
uniprot id: Q7ZYZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP regulatory subunit family.
messages: Cytoplasm

7955:LOC101884976
gene id: 7955:LOC101884976
uniprot id: A0A8M2B2S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:degs2
gene id: 7955:degs2
uniprot id: F1QW74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:ctnnb2
gene id: 7955:ctnnb2
uniprot id: Q8JID2
names: Similarity
messages: Belongs to the beta-catenin family.

7955:celsr3
gene id: 7955:celsr3
uniprot id: A0A8M3AV71
uniprot id: A0A8M3B208
uniprot id: A0A8M3B4X6
uniprot id: A0A8M6YZZ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor that may have an important role in cell/cell signaling during nervous system formation.

7955:si:dkey-33c12.16
gene id: 7955:si:dkey-33c12.16
uniprot id: A0A8M9QNZ8
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:kcnk13a
gene id: 7955:kcnk13a
uniprot id: A8KB76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

7955:si:ch73-368j24.3
gene id: 7955:si:ch73-368j24.3
uniprot id: A0A8M3B0X6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H3 family.
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus

7955:LOC101884438
gene id: 7955:LOC101884438
uniprot id: A0A8M9QG68
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family.

7955:LOC100147849
gene id: 7955:LOC100147849
uniprot id: A0A8M9QC84
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:si:ch1073-513e17.1
gene id: 7955:si:ch1073-513e17.1
uniprot id: A0A8M2B6K2
uniprot id: A0A8M9PRZ5
names: Subcellular Location Annotation
messages: Membrane

7955:ogg1
gene id: 7955:ogg1
uniprot id: A0A8N7V0N6
names: Similarity
messages: Belongs to the type-1 OGG1 family.

7955:clic1
gene id: 7955:clic1
uniprot id: Q6NYF2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane
messages: Nucleus membrane

7955:ctns
gene id: 7955:ctns
uniprot id: Q503T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystinosin family.
messages: Membrane

7955:LOC101883600
gene id: 7955:LOC101883600
uniprot id: A0A8M2BJQ7
names: Subcellular Location Annotation
messages: Membrane

7955:adipor1a
gene id: 7955:adipor1a
uniprot id: F1QJJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

7955:tshz1
gene id: 7955:tshz1
uniprot id: B3DJM5
uniprot id: F6NU84
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.
messages: Expressed in the 2-somite stage (10 hpf) in the neural keel between rhombomere 7 (r7) and the anterior spinal cord. Between the 2- and 20-somite stages (10-19 hpf), expressed caudally in the developing spinal cord. At 25 somite stage (21 hpf), detected throughout the spinal cord with expression levels gradually decreasing from anterior to posterior. At the prim-5 stage (24 hpf), detected in the pectoral fin buds and in the dorsal forebrain. At the long-pec stage (48 hpf), expressed in the telecephalon, tectum opticum, hindbrain, cerebellum, in the first pharyngeal arch, in the eyes and at very low level in the olfactory placodes. Around the protruding mouth stage (72-96 hpf), some expression is still detected in the eyes and only scattered expression is seen in the tectum, midbrain/hindbrain boundary and hindbrain. By the early larval stage (120 hpf), no expression is detected in the first pharyngeal arch and only low expression is detectable in the telecephalon, midbrain/hindbrain boundary, hindbrain and along the edges of the tectum.
messages: Nucleus
messages: Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential).
messages: Up-regulated in embryos by all-trans retinoic acid at the prim-5 stage (24 hpf) in more anterior regions of the neural tube, especially in the midbrain, with weaker expression in the forebrain and in the eye primordium.

7955:mapk8ip2
gene id: 7955:mapk8ip2
uniprot id: F1QF74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JIP scaffold family.
messages: Cytoplasm

7955:dnal1
gene id: 7955:dnal1
uniprot id: Q6DHB1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dynein light chain LC1-type family.
messages: Interacts with DNAH5, a outer arm dynein heavy chain. Interacts with tubulin located within the A-tubule of the outer doublets in a ATP-independent manner.
messages: Outer (ODAs) and inner (IDAs) dynein arms contain the molecular motors that generate the force to move cilia by ATP-dependent reactions. There are two mechanosensory systems that monitor and respond to the mechanical state (curvature) of the axoneme. One system involves the central pair microtubule complex and radial spokes and the second system involves the outer dynein arms.
messages: Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity).
messages: cilium axoneme

7955:man2b1
gene id: 7955:man2b1
uniprot id: A0A8M2BH83
uniprot id: Q58EM3
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

7955:ntmt1
gene id: 7955:ntmt1
uniprot id: A0A2R8Q009
uniprot id: F1QAE8
uniprot id: Q6NWX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. NTM1 family.
messages: Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on target proteins.
messages: Nucleus

7955:abraxas2a
gene id: 7955:abraxas2a
uniprot id: Q1LVP6
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAM175 family. Abraxas subfamily.
messages: Component of the ARISC complex. Component of the BRCA1-A complex. Homodimer (By similarity).
messages: Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (By similarity).
messages: Nucleus
messages: Phosphorylation of Ser-388 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1.
messages: There is no annotated ortholog of the vertebrate gene BRCA1 in the current zebrafish genome (PubMed:23594743). Therefore, mentions of brca1 in relevant curated zebrafish entries have been removed. However some complexes, conserved widely across species, have BRCA1 in their name and so have been left unchanged.

7955:chrm4a
gene id: 7955:chrm4a
uniprot id: E7F3U8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

7955:zgc:158234
gene id: 7955:zgc:158234
uniprot id: E9QDJ4
names: Similarity
messages: Belongs to the GCF family.

7955:calm1b
gene id: 7955:calm1b
uniprot id: Q6PI52
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the calmodulin family.
messages: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases.
messages: This protein has four functional calcium-binding sites.

7955:il19l
gene id: 7955:il19l
uniprot id: Q4LDR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

7955:mapk10
gene id: 7955:mapk10
uniprot id: A0A0R4I9H8
uniprot id: A0A0R4IB91
uniprot id: A0A0R4IKK9
uniprot id: A0A8M1P270
uniprot id: A0A8M2B8C2
uniprot id: A0A8M2B8D5
uniprot id: A0A8M3AWM8
uniprot id: A0A8M6YUI1
uniprot id: A0A8M6YV43
uniprot id: A0A8M6Z3P4
uniprot id: A0A8M9P3E5
uniprot id: A0A8M9PCS4
uniprot id: A4QP40
uniprot id: Q32LV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

7955:si:ch211-113a14.28
gene id: 7955:si:ch211-113a14.28
uniprot id: A7MCA7
uniprot id: Q5BJA5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-111 promotes monoubiquitination of Lys-119. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-119 by the BRE1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: Phosphorylated during apoptosis; which facilitates apoptotic chromatin condensation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:itga11b
gene id: 7955:itga11b
uniprot id: A0A8N7UV63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

7955:scarb1
gene id: 7955:scarb1
uniprot id: A0A0R4IDW0
uniprot id: A0A0R4IQE0
uniprot id: A0A0R4IRL8
uniprot id: A0A8M6Z8R4
names: Similarity
messages: Belongs to the CD36 family.

7955:spon2b
gene id: 7955:spon2b
uniprot id: Q0V935
names: Subcellular Location Annotation
messages: extracellular matrix

7955:snx30
gene id: 7955:snx30
uniprot id: Q566W7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Involved in the regulation of endocytosis and in several stages of intracellular trafficking. Together with snx4, involved in autophagosome assembly.

7955:tegt
gene id: 7955:tegt
uniprot id: A0A8M1RKH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

7955:gcnt3
gene id: 7955:gcnt3
uniprot id: F1RAK7
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

7955:fam151a
gene id: 7955:fam151a
uniprot id: A5PN38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM151 family.
messages: Membrane

7955:dnajc16l
gene id: 7955:dnajc16l
uniprot id: A0A8M9QDB3
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays an important role in regulating the size of autophagosomes during the formation process.

7955:LOC108183587
gene id: 7955:LOC108183587
uniprot id: A0A8M6Z5Q0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC100333218
gene id: 7955:LOC100333218
uniprot id: A0A8M9PK25
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

7955:zgc:77058
gene id: 7955:zgc:77058
uniprot id: Q6NXA8
names: Similarity
messages: Belongs to the UPF0461 family.

7955:thoc7
gene id: 7955:thoc7
uniprot id: Q6DGZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THOC7 family.
messages: Component of the THO subcomplex of the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling.
messages: Cytoplasm
messages: Nucleus
messages: Nucleus speckle
messages: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.

7955:yipf3
gene id: 7955:yipf3
uniprot id: Q803Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis (By similarity).
messages: cis-Golgi network membrane

7955:nudc
gene id: 7955:nudc
uniprot id: Q7ZVD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudC family.
messages: Midbody
messages: spindle

7955:yars2
gene id: 7955:yars2
uniprot id: A0A8M9PUY4
uniprot id: F1Q4R5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

7955:si:ch211-283g2.1
gene id: 7955:si:ch211-283g2.1
uniprot id: E9QDS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:mixl1
gene id: 7955:mixl1
uniprot id: Q5TYX1
names: Subcellular Location Annotation
messages: Nucleus

7955:mtmr7b
gene id: 7955:mtmr7b
uniprot id: A0A8M2BFN3
uniprot id: Q4V8X2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

7955:qpctlb
gene id: 7955:qpctlb
uniprot id: E9QEV8
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

7955:ND1
gene id: 7955:ND1
uniprot id: Q9MIZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

7955:slc24a2
gene id: 7955:slc24a2
uniprot id: A0A8M6YXT0
uniprot id: E9QFG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

7955:vps13d
gene id: 7955:vps13d
uniprot id: A0A8M9P5F9
uniprot id: A0A8M9PTG6
names: Similarity
messages: Belongs to the VPS13 family.

7955:tfdp1b
gene id: 7955:tfdp1b
uniprot id: A0A8M3B341
uniprot id: F1R508
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

7955:ostc
gene id: 7955:ostc
uniprot id: Q7ZWJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
messages: Specific component of the STT3A-containing form of the oligosaccharyltransferase (OST) complex.

7955:crbn
gene id: 7955:crbn
uniprot id: B2GQH0
uniprot id: Q68EH9
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CRBN family.
messages: Component of a DCX (DDB1-CUL4-X-box) protein ligase complex.
messages: Cytoplasm
messages: Highly expressed in brain, head, vasculature otic vesicles and developing pectoral fins.
messages: Nucleus
messages: Specific defects in fin and otic vesicle development.
messages: Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 (Probable). Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (PubMed:20223979). Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons. Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1 (By similarity). May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism (By similarity).
messages: Thalidomide is teratogenic in human, chicken and zebrafish, but not in mice. Binding of thalidomide and related drugs changes the substrate specificity of the human DCX (DDB1-CUL4-X-box) E3 protein ligase complex, leading to decreased degradation of endogenous target proteins and increased degradation of other proteins that are not normal substrates. This is probably the underlying cause of the teratogenic activity of thalidomide, possibly due to abnormal regulation of the BMP and FGF8 signaling pathways.

7955:hormad1
gene id: 7955:hormad1
uniprot id: A2BF66
names: Function
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus
messages: Plays a key role in meiotic progression by ensuring that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search, promoting synaptonemal-complex formation independently and playing key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint.

7955:kctd10
gene id: 7955:kctd10
uniprot id: Q6P7X5
names: Similarity
messages: Belongs to the BACURD family.

7955:zgc:136333
gene id: 7955:zgc:136333
uniprot id: A0A8M3B2U1
uniprot id: E9QG08
uniprot id: Q1ED20
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:vangl1
gene id: 7955:vangl1
uniprot id: A0A8M9QAM6
uniprot id: B0V210
uniprot id: Q6WN41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

7955:ccdc125
gene id: 7955:ccdc125
uniprot id: A2BGP7
names: Subcellular Location Annotation
messages: Cytoplasm

7955:zgc:110339
gene id: 7955:zgc:110339
uniprot id: Q568E7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:itgb7
gene id: 7955:itgb7
uniprot id: A0A8M9PN37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

7955:rras
gene id: 7955:rras
uniprot id: Q4V9D8
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

7955:chst1
gene id: 7955:chst1
uniprot id: A0A8M9PMP6
uniprot id: Q6DBY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan.

7955:or125-2
gene id: 7955:or125-2
uniprot id: Q2PRA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:homer3b
gene id: 7955:homer3b
uniprot id: Q7ZVW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

7955:pwp2h
gene id: 7955:pwp2h
uniprot id: Q7ZUV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PWP2 family.
messages: nucleolus

7955:mrpl11
gene id: 7955:mrpl11
uniprot id: Q6DGU3
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Binds directly to 26S ribosomal RNA.

7955:acap2
gene id: 7955:acap2
uniprot id: A7E2I2
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

7955:kcnf1a
gene id: 7955:kcnf1a
uniprot id: Q5SP96
names: Subcellular Location Annotation
messages: Membrane

7955:acsl3a
gene id: 7955:acsl3a
uniprot id: Q1LVA8
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

7955:amn
gene id: 7955:amn
uniprot id: A0A8M9QAN8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:rab38c
gene id: 7955:rab38c
uniprot id: A0A8N7T7H0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

7955:tpm4b
gene id: 7955:tpm4b
uniprot id: A0A1L6UW65
uniprot id: A0A8M6Z082
uniprot id: Q7SXW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

7955:syngr3b
gene id: 7955:syngr3b
uniprot id: A7E288
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

7955:numb
gene id: 7955:numb
uniprot id: A0A8M2BH45
uniprot id: A0A8M2BH67
uniprot id: F1RDZ7
uniprot id: Q1XD15
names: Function
messages: Plays a role in the process of neurogenesis.

7955:sept9a
gene id: 7955:sept9a
uniprot id: Q6TGX3
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

7955:mak16
gene id: 7955:mak16
uniprot id: F1QDC7
names: Similarity
messages: Belongs to the MAK16 family.

7955:slc30a10
gene id: 7955:slc30a10
uniprot id: A0A0R4IEQ2
uniprot id: A8WFU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

7955:mipa
gene id: 7955:mipa
uniprot id: Q6DEI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

7955:lamtor1
gene id: 7955:lamtor1
uniprot id: E7FBZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

7955:LOC101882573
gene id: 7955:LOC101882573
uniprot id: A0A8M6Z698
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:macf1a
gene id: 7955:macf1a
uniprot id: A0A8M2B696
uniprot id: A0A8M3AKC0
uniprot id: A0A8M3AL24
uniprot id: A0A8M3AL27
uniprot id: A0A8M3ASP2
uniprot id: A0A8M3ASP9
uniprot id: A0A8M3AVN6
uniprot id: A0A8M3AVP3
uniprot id: A0A8M3B3N5
uniprot id: A0A8M6YTZ6
uniprot id: A0A8M6YU02
uniprot id: A0A8M6YUK6
uniprot id: A0A8M6YUL3
uniprot id: A0A8M6YUL9
uniprot id: A0A8M6YWF8
uniprot id: A0A8M6YWG4
uniprot id: A0A8M6YWG9
uniprot id: A0A8M6Z2F9
uniprot id: A0A8M6Z2G6
uniprot id: A0A8M6Z318
uniprot id: A0A8M6Z325
uniprot id: A0A8M6Z331
uniprot id: A0A8M9P1Z8
uniprot id: A0A8M9PB61
uniprot id: A0A8M9PGN1
names: Subcellular Location Annotation
messages: cytoskeleton

7955:peli1b
gene id: 7955:peli1b
uniprot id: A4QN36
names: Similarity
messages: Belongs to the pellino family.

7955:acyp2
gene id: 7955:acyp2
uniprot id: E7EXH3
names: Similarity
messages: Belongs to the acylphosphatase family.

7955:bag6l
gene id: 7955:bag6l
uniprot id: A0A8M6YTY2
uniprot id: A0A8M6YTY7
uniprot id: A0A8M6YWF0
uniprot id: A3KPW9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the bag6/bat3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The bag6/bat3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Similarly, the bag6/bat3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The bag6/bat3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome. Also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. May ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress. By stabilizing a large spectrum of proteins, may indirectly affect different biological processes including apoptosis. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth…
messages: Component of the bag6/bat3 complex.
messages: Nucleus
messages: When nuclear, may also act as a component of some chromatin regulator complex.
messages: cytosol
messages: extracellular exosome

7955:pms2
gene id: 7955:pms2
uniprot id: E7F558
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

7955:dixdc1a
gene id: 7955:dixdc1a
uniprot id: Q804T6
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DIXDC1 family.
messages: Cytoplasm
messages: Expressed throughout the embryo including the shield. Strongly expressed in notochord and head regions from the bud to somite stages. Expressed in early born neurons in the telencephalic nucleus, the nuclei of the tract of the post-optic commissure and of the medial longitudinal fasciculus, and in segmental clusters of neurons in the hindbrain.
messages: Functions as a positive effector of the Wnt signaling pathway regulating antero-posterior neural patterning.
messages: Homomers. Interacts with dishevelled and axin1.
messages: The DIX domain mediates self-interaction and interaction with dishevelled and axin1.
messages: focal adhesion

7955:sema7a
gene id: 7955:sema7a
uniprot id: E7FBE1
uniprot id: X1WHP4
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:plppr5a
gene id: 7955:plppr5a
uniprot id: A5WUN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

7955:eomesb
gene id: 7955:eomesb
uniprot id: A1IJT6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7955:nr1h4
gene id: 7955:nr1h4
uniprot id: A0A8M2BHM4
uniprot id: Q6DGW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

7955:rnasekb
gene id: 7955:rnasekb
uniprot id: Q0P442
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase K family.
messages: Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds.
messages: Membrane

7955:valopb
gene id: 7955:valopb
uniprot id: A8YXX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

7955:ugt2a3
gene id: 7955:ugt2a3
uniprot id: B8JMA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7955:hdac1
gene id: 7955:hdac1
uniprot id: A0A2R8QIW0
uniprot id: Q8JIY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Nucleus

7955:limk1b
gene id: 7955:limk1b
uniprot id: E7FB16
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

7955:maf1
gene id: 7955:maf1
uniprot id: Q6PGU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAF1 family.
messages: Cytoplasm
messages: Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA (By similarity).
messages: Nucleus

7955:nkain1
gene id: 7955:nkain1
uniprot id: Q6PHL4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Interacts with atp1b1 C-terminus.

7955:scn1bb
gene id: 7955:scn1bb
uniprot id: B3F0A3
names: Subcellular Location Annotation
messages: Membrane

7955:bsk146
gene id: 7955:bsk146
uniprot id: B3DGG2
uniprot id: Q90ZY4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Expressed predominantly in the developing neural structures. Levels gradually increases from 36 to 144 hpf.
messages: Mainly expressed in brain.
messages: May be involved in the control of neuronal proliferation or migration in the brain of embryos.

7955:ahcyl1
gene id: 7955:ahcyl1
uniprot id: A5PMG3
uniprot id: Q7T2B5
names: Cofactor
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.

7955:f13a1a.1
gene id: 7955:f13a1a.1
uniprot id: F1QC84
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.

7955:ccdc32
gene id: 7955:ccdc32
uniprot id: X1WGV5
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with adaptor protein complex 2 (AP-2).
messages: Depletion of ccdc32 using CRISPR-Cas9-mediated gene editing results in disrupted cardiac looping in embryos at 2 dpf, reduced number and length of cilia in Kupffer's vesicle, and in a significant reduction of head size at 3 dpf. Furthermore, ccdc32 crispants exhibit significant alterations in facial skeletal morphology and have hypoplastic cerebella.
messages: Regulates clathrin-mediated endocytsois of cargos such as transferrin probably through the association and modulation of adaptor protein complex 2 (AP-2) (By similarity). Has a role in ciliogenesis and is required for proper cephalic and left/right axis development (PubMed:32307552).
messages: coated pit

7955:nle1
gene id: 7955:nle1
uniprot id: F1QDT3
names: Subcellular Location Annotation
messages: nucleolus

7955:si:dkey-86e18.2
gene id: 7955:si:dkey-86e18.2
uniprot id: Q5TYM7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in kidney, heart and skin (PubMed:29123523). Not expressed in muscle, ovary, gills, eyes or brain (PubMed:29123523).
messages: Highly expressed at fertilization.
messages: Morpholino knockdown results in reduced caspa activity and impairs caspa activity in response to bacterial infection with S.typhimurium (PubMed:29123523). In addition, larvae have increased susceptibility to the bacterium S.typhimurium (PubMed:29123523).
messages: Probable inflammasome component which mediates inflammasome-dependent resistance to bacterial infection by S.typhimurium through association with activated caspa.
messages: Self-associates (PubMed:29123523). Interacts with caspa (PubMed:29123523).
messages: Up-regulated in response to bacterial infection with S.typhimurium (PubMed:29123523). Highly expressed in macrophages when infected with S.typhimurium (PubMed:29123523).

7955:dlx5a
gene id: 7955:dlx5a
uniprot id: Q5XJL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

7955:zgc:63972
gene id: 7955:zgc:63972
uniprot id: A0A8M9Q3Q8
uniprot id: A9JRQ6
uniprot id: Q7T3C3
names: Similarity
names: Subunit
messages: Belongs to the CutA family.
messages: Homotrimer.

7955:crebbpb
gene id: 7955:crebbpb
uniprot id: A0A8M9PNF9
uniprot id: A0A8M9PUL2
uniprot id: A0A8M9Q1N8
names: Subcellular Location Annotation
messages: Cytoplasm

7955:cx47.1
gene id: 7955:cx47.1
uniprot id: Q66HV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

7955:lbx1a
gene id: 7955:lbx1a
uniprot id: Q6ZM39
names: Subcellular Location Annotation
messages: Nucleus

7955:cacng7a
gene id: 7955:cacng7a
uniprot id: E9QBQ5
uniprot id: F6NW67
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2.

7955:stx18
gene id: 7955:stx18
uniprot id: A0A8M3BEW8
uniprot id: Q4VBI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

7955:im:7156467
gene id: 7955:im:7156467
uniprot id: A0A8M9PKU1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:sumo2b
gene id: 7955:sumo2b
uniprot id: Q6DHL4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Cleavage of precursor form by a sentrin-specific protease is necessary for function.
messages: Interacts with sae2 and ube2i. Covalently attached to a number of proteins (By similarity).
messages: Nucleus
messages: Polymeric chains can be formed through Lys-11 cross-linking.
messages: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i, and can be promoted by an E3 ligase such as pias1-4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric sumo2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity).

7955:sacm1la
gene id: 7955:sacm1la
uniprot id: A4VCH0
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2).

7955:gramd1bb
gene id: 7955:gramd1bb
uniprot id: A0A8M6YTR6
uniprot id: A0A8M6YTS1
uniprot id: A0A8M6YUD5
uniprot id: A0A8M6YW88
uniprot id: A0A8M6Z276
uniprot id: A0A8M6Z2U8
uniprot id: A0A8M9P1J5
uniprot id: A0A8M9P1K0
uniprot id: A0A8M9PAM4
uniprot id: A0A8M9PAM7
uniprot id: A0A8M9PAN1
uniprot id: A0A8M9PG20
uniprot id: A0A8M9PG23
uniprot id: A0A8M9PMT0
uniprot id: A0A8M9PMT5
uniprot id: A0A8M9PMT9
uniprot id: A0A8M9PR30
uniprot id: A0A8M9PR35
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:hoxa9a
gene id: 7955:hoxa9a
uniprot id: B2GSB0
uniprot id: Q9PWL6
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: At the 10-somite stage, expressed in the paraxial mesoderm with an anterior expression limit at somite 8. At the 20-somite stage, expressed within the developing CNS with an anterior expression limit adjacent to the somite 4/5 boundary.
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

7955:LOC110437775
gene id: 7955:LOC110437775
uniprot id: Q6PBP4
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

7955:cygb2
gene id: 7955:cygb2
uniprot id: A0A2U3TVW6
uniprot id: A4IGG7
names: Similarity
messages: Belongs to the globin family.

7955:ireb2
gene id: 7955:ireb2
uniprot id: F1QNR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Cytoplasm

7955:zc3hc1
gene id: 7955:zc3hc1
uniprot id: Q08BA2
names: Subcellular Location Annotation
messages: Nucleus

7955:megf6a
gene id: 7955:megf6a
uniprot id: A0A8M3AYG1
uniprot id: A0A8M6Z4L7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:fgf6a
gene id: 7955:fgf6a
uniprot id: Q2LGG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Secreted

7955:fam46aa
gene id: 7955:fam46aa
uniprot id: A0A2R8Q5S3
names: Similarity
messages: Belongs to the TENT family.

7955:lhx6
gene id: 7955:lhx6
uniprot id: A0A8M3B623
uniprot id: Q6BDC4
names: Subcellular Location Annotation
messages: Nucleus

7955:prkar2b
gene id: 7955:prkar2b
uniprot id: A0A8M6Z4G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

7955:panx3
gene id: 7955:panx3
uniprot id: E7F7V4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

7955:cfap126
gene id: 7955:cfap126
uniprot id: Q0P4F6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the Flattop family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme. Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. Regulates kinocilium positioning and stereocilia bundle morphogenesis in the inner ear.
messages: cilium
messages: cilium axoneme
messages: cilium basal body

7955:si:dkey-229d2.4
gene id: 7955:si:dkey-229d2.4
uniprot id: A0A0R4ICC7
names: Subcellular Location Annotation
messages: Membrane

7955:pimr166
gene id: 7955:pimr166
uniprot id: A4IGE9
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:fzd3a
gene id: 7955:fzd3a
uniprot id: A0A8M2B7P5
uniprot id: Q5TZ38
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:hnrnpa1a
gene id: 7955:hnrnpa1a
uniprot id: A0A8M9PUQ8
uniprot id: A0A8M9QHJ0
uniprot id: Q7SXQ3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7955:zgc:153293
gene id: 7955:zgc:153293
uniprot id: A0A0R4IV07
names: Subcellular Location Annotation
messages: flagellum

7955:ldb1a
gene id: 7955:ldb1a
uniprot id: A0A8M2B2T8
uniprot id: A0A8M2B326
uniprot id: A0A8M2B3I2
uniprot id: A0A8M2B3N6
uniprot id: A0A8M3AZ24
uniprot id: A0A8M3B801
uniprot id: A0A8M3BEM2
uniprot id: A0A8M6Z275
uniprot id: A0A8M6Z3Q7
uniprot id: A0A8M6Z933
uniprot id: A0A8M9PXM7
uniprot id: O73715
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the LDB family.
messages: Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors.
messages: Expressed ubiquitously in the embryo and adult.
messages: Lacks LIM-binding domain.
messages: Nucleus

7955:colec12
gene id: 7955:colec12
uniprot id: A5PMY6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Scavenger receptor that displays several functions associated with host defense. Binds to carbohydrates (By similarity).

7955:gabrg3
gene id: 7955:gabrg3
uniprot id: A0A8M3B3K2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:st3gal1l
gene id: 7955:st3gal1l
uniprot id: B8K0C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

7955:six2b
gene id: 7955:six2b
uniprot id: B3DIJ7
names: Subcellular Location Annotation
messages: Nucleus

7955:piwil1
gene id: 7955:piwil1
uniprot id: Q8UVX0
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the argonaute family. Piwi subfamily.
messages: Cytoplasm
messages: Expressed exclusively in the adult gonads; expression in the ovary weaker than in the testis (at protein level). During neurogenesis and organogenesis, expression is detected in CNS (midbrain and eye) and fin buds. Starting from 24 hours post-fertilization, expression is found in the genital ridge.
messages: Initially detected during embryonic segmentation which persists for at least 4 weeks post hatching.
messages: Methylated on arginine residues; required for the interaction with Tudor domain-containing protein and subsequent localization to the meiotic nuage, also named P granule.
messages: Plays a central role during gametogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (PubMed:14516689, PubMed:17418787, PubMed:18833190). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:14516689, PubMed:17418787, PubMed:18833190). Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (PubMed:14516689, PubMed:17418787, PubMed:18833190). Has a strong preference for piRNAs with a uridine nucleotide at their 5'-end (g1U preference, also named 1U-bias) and binds piRNAs in an opposite direction compared to piwil2/zili (PubMed:14516689, PubMed:17418787, PubMed:18833190). Participates in a piRNA amplification loop with piwil2/zili (PubMed:14516689, PubMed:17418787, PubMed:18833190). Not involved in the piRNA amplification loop, also named ping-pong amplification cycle. Acts as an endoribonuclease that cleaves transposon messenger RNAs (By similarity).
messages: Progressive loss of germ cells due to apoptosis during larval development.
messages: The PAZ domain specifically recognizes binds the 2'-O-methylated 3'-end of piRNAs. The MID region is required for recognition of uridine in the first position of piRNAs (g1U preference, also named 1U-bias).

7955:kcna4
gene id: 7955:kcna4
uniprot id: F1Q929
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: axon

7955:si:ch73-151m17.5
gene id: 7955:si:ch73-151m17.5
uniprot id: X1WE62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

7955:cmpk
gene id: 7955:cmpk
uniprot id: A5WWI2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

7955:amn1
gene id: 7955:amn1
uniprot id: Q0P4D1
names: Similarity
messages: Belongs to the AMN1 family.

7955:si:ch211-137j23.9
gene id: 7955:si:ch211-137j23.9
uniprot id: A0A8M9NYV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

7955:selt1b
gene id: 7955:selt1b
uniprot id: Q6PHY8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SelWTH family. Selenoprotein T subfamily.
messages: Endoplasmic reticulum membrane
messages: May contain a selenide-sulfide bond between Cys-44 and Sec-47. This bond is speculated to serve as redox-active pair (By similarity).
messages: Selenoprotein with thioredoxin reductase-like oxidoreductase activity.
messages: Widely expressed in the embryo. High level in embryonic blood at 24 hours post-fertilization (hpf).

7955:si:rp71-46j2.7
gene id: 7955:si:rp71-46j2.7
uniprot id: A0A140LGW1
uniprot id: A0A8M3AI12
uniprot id: A0A8M3B0G2
names: Similarity
messages: Belongs to the sorting nexin family.

7955:eif4ebp3l
gene id: 7955:eif4ebp3l
uniprot id: Q98TT6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF4E-binding protein family.
messages: Interacts with eif4e1a.
messages: Regulates eif4e1a activity by preventing its assembly into the eIF4F complex.

7955:si:ch211-30b16.2
gene id: 7955:si:ch211-30b16.2
uniprot id: A0A8M6YWE1
uniprot id: Q1L8D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:LOC563567
gene id: 7955:LOC563567
uniprot id: A0A8M9PYR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:si:dkeyp-33b5.4
gene id: 7955:si:dkeyp-33b5.4
uniprot id: X1WBZ5
names: Similarity
messages: Belongs to the PPR family. P subfamily.

7955:fabp7b
gene id: 7955:fabp7b
uniprot id: Q6U1J7
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

7955:chrnb2l
gene id: 7955:chrnb2l
uniprot id: A0A140LGX8
uniprot id: A0A8M9PZX4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:si:ch211-286f9.2
gene id: 7955:si:ch211-286f9.2
uniprot id: E7FDV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nitroreductase family.
messages: Catalyzes the dehalogenation of halotyrosines such as 3,5-diiodo-L-tyrosine (PubMed:24153409). Likely to also catalyze the dehalogenation of other halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine and 3-iodo-L-tyrosine (By similarity).
messages: Membrane

7955:cox6b1
gene id: 7955:cox6b1
uniprot id: Q6DH63
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

7955:cd44b
gene id: 7955:cd44b
uniprot id: A0A8M3APC4
uniprot id: A0A8M6YYL8
uniprot id: A0A8M6Z4J5
uniprot id: A0A8M6Z569
uniprot id: X1WBP3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: microvillus

7955:pkd1l3
gene id: 7955:pkd1l3
uniprot id: A0A8M9QI22
names: Caution
names: Similarity
messages: Belongs to the polycystin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:aldh1l1
gene id: 7955:aldh1l1
uniprot id: E3NZ06
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.

7955:def8
gene id: 7955:def8
uniprot id: A0A0R4IHS8
uniprot id: A0A8M3AJN0
uniprot id: A0A8M9PFE2
names: Similarity
messages: Belongs to the DEF8 family.

7955:gig2i
gene id: 7955:gig2i
uniprot id: E7F7D7
names: Similarity
messages: Belongs to the ARTD/PARP family.

7955:sms
gene id: 7955:sms
uniprot id: Q9YGC9
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

7955:bap1
gene id: 7955:bap1
uniprot id: A0A8M2BL95
uniprot id: A0A8M2BLM6
uniprot id: F1QJ12
names: Similarity
messages: Belongs to the peptidase C12 family.

7955:puraa
gene id: 7955:puraa
uniprot id: Q6JIZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

7955:vimp
gene id: 7955:vimp
uniprot id: Q0VFV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selenoprotein S family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner (By similarity).

7955:pigl
gene id: 7955:pigl
uniprot id: A0A8M1P3K2
uniprot id: A5PLH9
names: Function
names: Similarity
messages: Belongs to the PIGL family.
messages: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

7955:drd3
gene id: 7955:drd3
uniprot id: A0A8M9PTW6
uniprot id: F1QG18
uniprot id: Q8AWE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:kdelr3
gene id: 7955:kdelr3
uniprot id: Q6PFS5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: Binds the C-terminal sequence motif K-D-E-L in a hydrophilic cavity between the transmembrane domains. This triggers a conformation change that exposes a Lys-rich patch on the cytosolic surface of the protein (By similarity). This patch mediates recycling from the Golgi to the endoplasmic reticulum, probably via COPI vesicles (By similarity).
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.

7955:esrrgb
gene id: 7955:esrrgb
uniprot id: B3DIZ0
uniprot id: Q5RJ38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

7955:tmem63a
gene id: 7955:tmem63a
uniprot id: A4QP59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

7955:kcnn1a
gene id: 7955:kcnn1a
uniprot id: A0A0R4INU5
uniprot id: A0A8M2BIK5
uniprot id: A0A8M2BIZ6
uniprot id: A0A8M9QA92
uniprot id: A0A8M9QNQ2
uniprot id: A0A8M9QNT3
names: Subcellular Location Annotation
messages: Membrane

7955:trim35-30
gene id: 7955:trim35-30
uniprot id: Q1L9F9
names: Subcellular Location Annotation
messages: Cytoplasm

7955:serinc1
gene id: 7955:serinc1
uniprot id: Q7SZW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

7955:nefla
gene id: 7955:nefla
uniprot id: A0A8M9PUK6
names: Similarity
messages: Belongs to the intermediate filament family.

7955:zranb1b
gene id: 7955:zranb1b
uniprot id: A0JMQ9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C64 family.
messages: Cytoplasm
messages: Nucleus
messages: The OTU domain mediates the deubiquitinating activity.
messages: The RanBP2-type zinc fingers, also called NZFs, mediate the interaction with ubiquitin and determine linkage specificity. RanBP2-type zinc fingers 1 and 2 (also named NZF1 and NZF2) specifically recognize and bind 'Lys-29'- and 'Lys-33'-linked ubiquitin. RanBP2-type zinc finger 3 (also named NZF3) binds 'Lys-33'-linked ubiquitin and shows weak binding to 'Lys-6'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin chains but it does not interact with 'Lys-29'-linked chains.
messages: The second ankyrin repeat ANK 2 is termed AnkUBD, it interacts with ubiquitin hydrophobic patch and contributes to linkage specificity.
messages: Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin (By similarity). Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones (By similarity). Positive regulator of the Wnt signaling pathway that deubiquitinates apc protein, a negative regulator of Wnt-mediated transcription (By similarity). Acts as a regulator of autophagy by mediating deubiquitination of pik3c3/vps34, thereby promoting autophagosome maturation (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Required in the stress fiber dynamics and cell migration (By similarity).

7955:ca12
gene id: 7955:ca12
uniprot id: A0A8M3AP67
uniprot id: A0A8M3AWN7
uniprot id: A0A8M3AZS0
uniprot id: A0A8M6YWQ0
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

7955:mex3c
gene id: 7955:mex3c
uniprot id: A0A8M1REM5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7955:gng4
gene id: 7955:gng4
uniprot id: A0A8M9Q1C1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

7955:accs
gene id: 7955:accs
uniprot id: F1QMK2
uniprot id: Q58ES0
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

7955:LOC100334869
gene id: 7955:LOC100334869
uniprot id: A7MCA7
uniprot id: Q5BJA5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-111 promotes monoubiquitination of Lys-119. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-119 by the BRE1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: Phosphorylated during apoptosis; which facilitates apoptotic chromatin condensation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:ccdc126
gene id: 7955:ccdc126
uniprot id: Q0P3Y5
names: Subcellular Location Annotation
messages: Secreted

7955:nme2a
gene id: 7955:nme2a
uniprot id: A0A8M9PP44
uniprot id: Q6PC37
names: Similarity
messages: Belongs to the NDK family.

7955:marveld1
gene id: 7955:marveld1
uniprot id: Q5BLB7
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

7955:ntd5
gene id: 7955:ntd5
uniprot id: A0A8M9PJY1
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:hbae1.3
gene id: 7955:hbae1.3
uniprot id: Q7ZT21
names: Similarity
messages: Belongs to the globin family.

7955:si:ch211-212k18.13
gene id: 7955:si:ch211-212k18.13
uniprot id: A0A8M9Q292
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
messages: Belongs to the peptidase C19 family.

7955:idh2
gene id: 7955:idh2
uniprot id: Q7ZUP6
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

7955:galnt16
gene id: 7955:galnt16
uniprot id: X1WGF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

7955:psma5
gene id: 7955:psma5
uniprot id: Q6TGV6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

7955:ap2m1a
gene id: 7955:ap2m1a
uniprot id: F1Q9V1
uniprot id: Q6NWK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit and beta-type subunit), a medium adaptin (mu-type subunit) and a small adaptin (sigma-type subunit).
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositide-containing lipids (By similarity).
messages: coated pit

7955:mrpl9
gene id: 7955:mrpl9
uniprot id: A8E5P5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

7955:dot1l
gene id: 7955:dot1l
uniprot id: A0A8M2BHW6
uniprot id: A0A8M3AUT9
uniprot id: A0A8M3AXT4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
messages: Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
messages: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
messages: Nucleus

7955:gabra6b
gene id: 7955:gabra6b
uniprot id: F1QGW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:aimp2
gene id: 7955:aimp2
uniprot id: A0A8M9PXA5
uniprot id: Q7T3C0
names: Subcellular Location Annotation
messages: Nucleus
messages: cytosol

7955:sec23b
gene id: 7955:sec23b
uniprot id: A0A8M6Z6P7
uniprot id: Q7ZVV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

7955:napepld
gene id: 7955:napepld
uniprot id: A0A2R8RJ40
uniprot id: A0A8M2BC81
uniprot id: Q5TZE8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPE-PLD family.
messages: Binds 2 zinc divalent cations per subunit.
messages: Homodimer. Bile acids promote the assembly of inactive monomers into an active dimer and enable catalysis.
messages: Nucleus envelope

7955:emp3b
gene id: 7955:emp3b
uniprot id: Q4V8V3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:LOC100536819
gene id: 7955:LOC100536819
uniprot id: A0A8M1RP90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:si:ch211-202f3.4
gene id: 7955:si:ch211-202f3.4
uniprot id: A0A8M9PLL2
uniprot id: E7F0H3
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:itih3a
gene id: 7955:itih3a
uniprot id: Q503P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

7955:dand5
gene id: 7955:dand5
uniprot id: Q76C29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

7955:neurod2
gene id: 7955:neurod2
uniprot id: Q9W6C8
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Embryonic, larval and adult stages. Expression is weak from 10 to 48 hours post-fertilization (hpf) and increases from 72 hpf.
messages: In adult, expressed strongly in brain and more weakly in skin, muscle, eye and ovary.
messages: Nucleus
messages: Transcriptional regulator. Appears to mediate neuronal differentiation (By similarity).

7955:tmem121b
gene id: 7955:tmem121b
uniprot id: A0A8M1NPS8
names: Similarity
messages: Belongs to the TMEM121 family.

7955:pdcd10b
gene id: 7955:pdcd10b
uniprot id: Q6NWL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDCD10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Interacts (via C-terminus) with CCM2. Interacts (via N-terminus) with STK25 and STK26.
messages: Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Required for normal cardiovascular development (PubMed:19370760).

7955:si:ch1073-179p4.3
gene id: 7955:si:ch1073-179p4.3
uniprot id: A0A8M3AS04
uniprot id: F1Q6Z6
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

7955:eif5a
gene id: 7955:eif5a
uniprot id: Q6NX89
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-5A family.
messages: Binds to 80S ribosomes (PubMed:36653451). Actively translating ribosomes show mutually exclusive binding of eIF5a (eif5a or eif5a2) and eef2/eEF2 (By similarity). Interacts with dapl1/dap1b; interaction takes place at the polypeptide exit tunnel of hibernating ribosomes and prevents translation (PubMed:36653451).
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Lys-51 undergoes hypusination, a unique post-translational modification that consists in the addition of a butylamino group from spermidine to lysine side chain, leading to the formation of the unusual amino acid hypusine. eIF-5As are the only known proteins to undergo this modification, which is essential for their function.
messages: Nucleus
messages: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (By similarity). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome (By similarity). Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (By similarity).

7955:zgc:56493
gene id: 7955:zgc:56493
uniprot id: Q7ZUI4
names: Similarity
messages: Belongs to the thioredoxin family.

7955:LOC100006542
gene id: 7955:LOC100006542
uniprot id: A0A8M1PT00
names: Similarity
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.

7955:nog3
gene id: 7955:nog3
uniprot id: Q9YHV3
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the noggin family.
messages: Expression is limited to late stages of embryogenesis. First detected at 48 hours of development and restricted to regions of ongoing chondrogenesis. Expression is observed in the ethmoid plate and the trabeculae cranii of the neurocranium as well as in some presumptive cartilage cells of the pharyngeal arches. Expression is furthermore observed in the forming cartilage of the pectoral fins. At 72 hours of development, accumulates in the ceratobranchial and basibranchial parts of the gill arches.
messages: Homodimer; disulfide-linked.
messages: May function as an inhibitor of bone morphogenetic proteins (BMP) signaling during later stages of development including late phases of dorsoventral patterning, to refine the early pattern set up by the interaction of chordino and BMP2/4. Not involved in organizer function or early phases of dorsoventral pattern formation.
messages: Secreted

7955:LOC100536506
gene id: 7955:LOC100536506
uniprot id: A0A8M9PDR1
uniprot id: A0A8M9Q7M5
names: Subcellular Location Annotation
messages: Nucleus

7955:fep15
gene id: 7955:fep15
uniprot id: A0A8M1NW48
names: Similarity
messages: Belongs to the selenoprotein M/F family.

7955:baiap2l2b
gene id: 7955:baiap2l2b
uniprot id: Q1LWE6
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures.
messages: The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation (By similarity).

7955:msx3
gene id: 7955:msx3
uniprot id: Q7ZZ01
names: Subcellular Location Annotation
messages: Nucleus

7955:or115-12
gene id: 7955:or115-12
uniprot id: A0A8M9PU20
uniprot id: Q32PT6
names: Subcellular Location Annotation
messages: Membrane

7955:fam83d
gene id: 7955:fam83d
uniprot id: A4QP72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM83 family.
messages: Cytoplasm
messages: May regulate cell proliferation, growth, migration and epithelial to mesenchymal transition. May also be important for proper chromosome congression and alignment during mitosis.
messages: spindle
messages: spindle pole

7955:ms4a17a.10
gene id: 7955:ms4a17a.10
uniprot id: X1WE70
names: Similarity
messages: Belongs to the MS4A family.

7955:tmed4
gene id: 7955:tmed4
uniprot id: Q6IQH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:slc25a33
gene id: 7955:slc25a33
uniprot id: Q6P036
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria which participates in dendritic cell endocytosis.
messages: Mitochondrion inner membrane

7955:g6pcb
gene id: 7955:g6pcb
uniprot id: X1WDY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

7955:LOC101885990
gene id: 7955:LOC101885990
uniprot id: A0A8M6Z573
names: Subcellular Location Annotation
messages: Membrane

7955:taar19r
gene id: 7955:taar19r
uniprot id: A0A8M6Z335
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:hist1h4l
gene id: 7955:hist1h4l
uniprot id: A3KPR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:emx1
gene id: 7955:emx1
uniprot id: A3KNV6
uniprot id: Q804S6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMX homeobox family.
messages: May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.
messages: Nucleus

7955:si:ch1073-205c8.3
gene id: 7955:si:ch1073-205c8.3
uniprot id: A0A0R4IUU4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7955:anxa1c
gene id: 7955:anxa1c
uniprot id: Q804H0
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

7955:tbr1a
gene id: 7955:tbr1a
uniprot id: E7FCP0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7955:wdr78
gene id: 7955:wdr78
uniprot id: F1QHZ6
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Dynein axonemal particle
messages: Morpholino knockdown results in ciliopathy-related phenotypes, such as curved bodies, hydrocephalus, abnormal otolith, randomized left-right asymmetry, and pronephric cysts, accompanied with paralyzed pronephric cilia.
messages: Part of the multisubunit axonemal dynein complex formed at least of two heavy chains and a number of intermediate and light chains.
messages: Plays a critical role in the assembly of axonemal dynein complex (By similarity). Plays a key role in ciliary motility (PubMed:30060180).
messages: cilium axoneme
messages: flagellum axoneme

7955:cox7a2a
gene id: 7955:cox7a2a
uniprot id: Q504B4
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

7955:timp2b
gene id: 7955:timp2b
uniprot id: Q6NUX9
names: Similarity
messages: Belongs to the protease inhibitor I35 (TIMP) family.

7955:si:dkey-23a13.5
gene id: 7955:si:dkey-23a13.5
uniprot id: Q05AK8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:adrb3b
gene id: 7955:adrb3b
uniprot id: A0A8M9QKR9
uniprot id: B3DIE4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:tmsb
gene id: 7955:tmsb
uniprot id: Q1RM34
uniprot id: Q9W7M8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

7955:prkcz
gene id: 7955:prkcz
uniprot id: A0A8M3AV14
uniprot id: A0A8M3B1V2
uniprot id: A0A8M3BBP0
uniprot id: Q4JG04
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

7955:uckl1b
gene id: 7955:uckl1b
uniprot id: A0A8M2B8W6
uniprot id: A0A8M2B8Y1
uniprot id: F1QWG3
names: Similarity
messages: Belongs to the uridine kinase family.

7955:tceb1a
gene id: 7955:tceb1a
uniprot id: A0A8M2B9H7
uniprot id: Q66IB1
names: Similarity
messages: Belongs to the SKP1 family.

7955:gdap2
gene id: 7955:gdap2
uniprot id: Q66HX8
names: Similarity
messages: Belongs to the GDAP2 family.

7955:irf10
gene id: 7955:irf10
uniprot id: A8E5I1
uniprot id: Q6NY63
names: Subcellular Location Annotation
messages: Nucleus

7955:prop1
gene id: 7955:prop1
uniprot id: A0A2R8QKN2
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.

7955:col4a6
gene id: 7955:col4a6
uniprot id: A0A8M3B4D5
uniprot id: A0A8M6Z091
uniprot id: A0A8M6Z1T7
uniprot id: A0A8M6Z7E0
uniprot id: A0A8M9QD06
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

7955:znf706
gene id: 7955:znf706
uniprot id: Q6TGY0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7955:uso1
gene id: 7955:uso1
uniprot id: A0A2R8QLN9
uniprot id: A0A8M3APK5
uniprot id: E7F2J5
uniprot id: Q7ZW40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VDP/USO1/EDE1 family.
messages: Membrane

7955:capn8
gene id: 7955:capn8
uniprot id: A0A8M1NYR6
names: Similarity
messages: Belongs to the peptidase C2 family.

7955:rassf1
gene id: 7955:rassf1
uniprot id: Q66HV2
names: Subcellular Location Annotation
messages: cytoskeleton

7955:rabggtb
gene id: 7955:rabggtb
uniprot id: Q4V946
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

7955:LOC100002814
gene id: 7955:LOC100002814
uniprot id: A0A0G2KHZ9
names: Subcellular Location Annotation
messages: Membrane

7955:LOC101882407
gene id: 7955:LOC101882407
uniprot id: E7EYF8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7955:fam193b
gene id: 7955:fam193b
uniprot id: A0A0R4ICN6
names: Similarity
messages: Belongs to the FAM193 family.

7955:fam83b
gene id: 7955:fam83b
uniprot id: E7F4Q7
names: Similarity
messages: Belongs to the FAM83 family.

7955:apobb.2
gene id: 7955:apobb.2
uniprot id: A0A8M1RMK1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC100537475
gene id: 7955:LOC100537475
uniprot id: A0A8M9P1L3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:sema3bl
gene id: 7955:sema3bl
uniprot id: M9MM97
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC100333907
gene id: 7955:LOC100333907
uniprot id: A0A8M3B377
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

7955:LOC562362
gene id: 7955:LOC562362
uniprot id: A0A8M9PLJ2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:ift22
gene id: 7955:ift22
uniprot id: Q567Y6
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

7955:zgc:112271
gene id: 7955:zgc:112271
uniprot id: Q502F6
names: Similarity
messages: Belongs to the BolA/IbaG family.

7955:slc6a19a.1
gene id: 7955:slc6a19a.1
uniprot id: A5D6R9
uniprot id: Q1RLZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:si:ch211-262i1.4
gene id: 7955:si:ch211-262i1.4
uniprot id: A0A8M9QIH5
names: Subcellular Location Annotation
messages: Membrane

7955:LOC100536910
gene id: 7955:LOC100536910
uniprot id: A0A8M9QD94
names: Subcellular Location Annotation
messages: Membrane

7955:pimr93
gene id: 7955:pimr93
uniprot id: A0A8M9PVA2
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:dlat
gene id: 7955:dlat
uniprot id: F6NRK1
uniprot id: Q804C3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Mitochondrion
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

7955:xk
gene id: 7955:xk
uniprot id: A0A8M9QLM0
uniprot id: Q5GH44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

7955:uba3
gene id: 7955:uba3
uniprot id: A0A8M2B283
uniprot id: B2GSP4
uniprot id: Q7ZVX6
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Arg-210 acts as a selectivity gate, preventing misactivation of ubiquitin by this NEDD8-specific E1 complex.
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric uba3-nae1 E1 enzyme. E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP. E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity).
messages: Heterodimer of uba3 and nae1. Interacts with nedd8, ube2f and ube2m (By similarity).

7955:zgc:172091
gene id: 7955:zgc:172091
uniprot id: A0A8M1NHQ0
uniprot id: A8WG00
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:pgd
gene id: 7955:pgd
uniprot id: F1Q883
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

7955:gstm.3
gene id: 7955:gstm.3
uniprot id: B8JIS5
names: Similarity
messages: Belongs to the GST superfamily. Mu family.

7955:slc25a22
gene id: 7955:slc25a22
uniprot id: A0A8M2BJZ1
uniprot id: Q7ZTT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7955:slc34a1a
gene id: 7955:slc34a1a
uniprot id: F8W579
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

7955:cacna2d2a
gene id: 7955:cacna2d2a
uniprot id: A0A1D5NSP7
uniprot id: A0A8M3ATR3
uniprot id: A0A8M3B0S8
uniprot id: A0A8M3BAM9
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

7955:cops7a
gene id: 7955:cops7a
uniprot id: F6PBL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

7955:fam207a
gene id: 7955:fam207a
uniprot id: Q1LWH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLX9 family.
messages: nucleolus

7955:etfa
gene id: 7955:etfa
uniprot id: Q7ZUS9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

7955:hrasls
gene id: 7955:hrasls
uniprot id: A0A0R4IY06
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the H-rev107 family.
messages: Endoplasmic reticulum membrane
messages: Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids. Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid. Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE) which serves as precursor for N-acylethanolamines (NAEs) (By similarity). Required for complete organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light (PubMed:33854238). Organelle membrane degradation is probably catalyzed by the phospholipase activity (PubMed:33854238) (By similarity).
messages: Expressed in the eye lens.
messages: Knockout animals exhibit normal growth of their body and eye lens. However, the disappearance of mitochondria and the endoplasmic reticulum in the lens is almost completely suppressed and membranous structures persisted in the lens central region.
messages: Lysosome membrane
messages: Membrane
messages: Mitochondrion membrane
messages: The C-terminal transmembrane domain is required for the targeting of the protein to damaged organelles.
messages: cytosol

7955:adcyap1r1a
gene id: 7955:adcyap1r1a
uniprot id: Q5C8U6
uniprot id: Q5C8U8
uniprot id: Q5C8V0
names: Subcellular Location Annotation
messages: Membrane

7955:foxm1
gene id: 7955:foxm1
uniprot id: A0A8M9PUA7
uniprot id: Q7T2G3
names: Subcellular Location Annotation
messages: Nucleus

7955:pbk
gene id: 7955:pbk
uniprot id: Q6DHU8
names: Activity Regulation
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
messages: Phosphorylated; in a cell-cycle dependent manner at mitosis.

7955:ins
gene id: 7955:ins
uniprot id: B2GSI0
uniprot id: O73727
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
messages: Secreted

7955:zgc:103499
gene id: 7955:zgc:103499
uniprot id: Q5PR55
names: Function
names: PTM
messages: AMPylates itself (auto-AMPylation).
messages: Functions as an RNA ligase, in vitro. The ligation reaction entails three nucleotidyl transfer steps. In the first step, the RNA ligase reacts with ATP in the absence of nucleic acid to form a covalent ligase-AMP intermediate and release pyrophosphate. In step 2, the ligase-AMP binds to the nucleic acid and transfers the adenylate to the 5'-PO4 terminus to form an adenylylated intermediate. In step 3, the RNA ligase directs the attack of the 3'-OH on the 5'-phosphoanhydride linkage, resulting in a repaired 3'-5' phosphodiester and release of AMP. Exhibits selectivity for single-stranded RNA substrates and may not have nick-sealing activity on double-stranded DNA-RNA hybrids. May play a role in maintaining RNA integrity under stress conditions, for example in response to reactive oxygen species (ROS).

7955:epha5
gene id: 7955:epha5
uniprot id: A0A8M9QGV0
uniprot id: E7F2W4
names: Subcellular Location Annotation
messages: Membrane

7955:sec16b
gene id: 7955:sec16b
uniprot id: A0A8N7TCU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC16 family.
messages: Endoplasmic reticulum membrane

7955:pigm
gene id: 7955:pigm
uniprot id: Q7T310
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGM family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly (By similarity).

7955:mpeg1.3
gene id: 7955:mpeg1.3
uniprot id: B0R063
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPEG1 family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

7955:fat3a
gene id: 7955:fat3a
uniprot id: A0A2R8QAL3
uniprot id: A0A8M6Z1C0
uniprot id: A0A8M9Q0H4
uniprot id: A0A8M9QLG7
uniprot id: F1QA09
uniprot id: X1WCY4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:si:zfos-1192g2.3
gene id: 7955:si:zfos-1192g2.3
uniprot id: E7F2E7
names: Similarity
messages: Belongs to the Iojap/RsfS family.

7955:zgc:162171
gene id: 7955:zgc:162171
uniprot id: A3KNK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

7955:LOC103910188
gene id: 7955:LOC103910188
uniprot id: A0A8M9PTW8
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:zgc:153169
gene id: 7955:zgc:153169
uniprot id: A0A8M3BEP7
uniprot id: F1QE55
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

7955:shox
gene id: 7955:shox
uniprot id: A0A8M2BFC1
uniprot id: B0S5T0
names: Subcellular Location Annotation
messages: Nucleus

7955:mapk7
gene id: 7955:mapk7
uniprot id: E9QEY0
uniprot id: Q0H1F4
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

7955:zdhhc9
gene id: 7955:zdhhc9
uniprot id: F1R013
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates.
messages: Probably maternally supplied, the zygotic expression becomes significant at the 512-cell stage and increases until 10 hpf and then decreases but is still detected at 24 hpf.
messages: The DHHC domain is required for palmitoyltransferase activity.

7955:LOC100331508
gene id: 7955:LOC100331508
uniprot id: A0A8M3BAQ8
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

7955:adam12
gene id: 7955:adam12
uniprot id: A0A0R4INJ8
uniprot id: A0A8M6YVV0
uniprot id: A0A8M9QJC4
uniprot id: A0A8M9QN43
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:arpc5lb
gene id: 7955:arpc5lb
uniprot id: A0A8M3ASH3
uniprot id: B0S516
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

7955:si:dkeyp-9d4.5
gene id: 7955:si:dkeyp-9d4.5
uniprot id: A0A8M9QDD8
uniprot id: F1Q7N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

7955:si:ch211-113j13.2
gene id: 7955:si:ch211-113j13.2
uniprot id: A0A8M9PIY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

7955:dpy19l1l
gene id: 7955:dpy19l1l
uniprot id: Q6DRN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

7955:sh3gl3a
gene id: 7955:sh3gl3a
uniprot id: A1L2A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

7955:grk7b
gene id: 7955:grk7b
uniprot id: Q49HM8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

7955:snap25b
gene id: 7955:snap25b
uniprot id: Q6PC54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Expressed in several regions throughout the adult brain, including the mesencephalon.
messages: May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion.
messages: synaptosome

7955:ankzf1
gene id: 7955:ankzf1
uniprot id: A0A8M6Z8J2
uniprot id: E7F4D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKZF1/VMS1 family.
messages: Cytoplasm

7955:mcoln2
gene id: 7955:mcoln2
uniprot id: Q803Y8
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

7955:cyp7a1b
gene id: 7955:cyp7a1b
uniprot id: E7FCW9
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:rbfox1
gene id: 7955:rbfox1
uniprot id: A0A8M6YVW0
uniprot id: A0A8M6YWH2
uniprot id: A0A8M6YWH6
uniprot id: A0A8M6YYC7
uniprot id: A0A8M6Z4X9
uniprot id: A0A8M9P6B9
uniprot id: A0A8M9P6C2
uniprot id: A0A8M9PMK8
uniprot id: A0A8M9PUS3
uniprot id: A0A8M9PUS8
uniprot id: A0A8M9PY70
uniprot id: A0A8M9PY74
uniprot id: A0A8M9PY79
uniprot id: A0A8M9PY89
uniprot id: Q642J5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons (By similarity).
messages: RNA-binding protein that regulates alternative splicing events.

7955:LOC100332583
gene id: 7955:LOC100332583
uniprot id: A0A8M1RHY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

7955:trpc7b
gene id: 7955:trpc7b
uniprot id: U3N9R0
names: Subcellular Location Annotation
messages: Membrane

7955:adgrg7.1
gene id: 7955:adgrg7.1
uniprot id: A0A8M9PJW1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:caprin2
gene id: 7955:caprin2
uniprot id: B7ZVU9
uniprot id: Q5RJ80
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the caprin family.
messages: Cell membrane
messages: Cytoplasm
messages: Homotrimer; via C1q domain.
messages: Morpholino knockdown results in a dorsalized phenotype, with enlargement of the telencephalon and reduction of the tail at 24 hours post-fertilization. Expression of the dorsal marker goosecoid is expanded, whereas expression of the ventral markers eve1 and tbx6 is reduced. In addition, expression of the telencephalon marker opl and the midbrain/hindbrain boundary marker pax2.1 is expanded posteriorly.
messages: Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway. Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling. May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis.
messages: The C1q domain is essential for the function in Wnt signaling.

7955:acy3.1
gene id: 7955:acy3.1
uniprot id: Q6DHI0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the AspA/AstE family. Aspartoacylase subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Plays an important role in deacetylating mercapturic acids in kidney proximal tubules.

7955:c1qtnf12
gene id: 7955:c1qtnf12
uniprot id: A1A5X5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adipolin/erythroferrone family.
messages: Homomultimer; disulfide-linked.
messages: Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue.
messages: Secreted

7955:tmeff2a
gene id: 7955:tmeff2a
uniprot id: B0S6Y8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:rpl39
gene id: 7955:rpl39
uniprot id: Q6IMW8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

7955:tnpo2
gene id: 7955:tnpo2
uniprot id: Q68EK8
names: Subcellular Location Annotation
messages: Cytoplasm

7955:ptcd2
gene id: 7955:ptcd2
uniprot id: F1QQL7
uniprot id: Q566X6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTCD2 family.
messages: Involved in mitochondrial RNA maturation and mitochondrial respiratory chain function.
messages: Mitochondrion

7955:mylk3
gene id: 7955:mylk3
uniprot id: A8C984
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: At 24 and 48 hours post fertilization, expressed only in the heart.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Kinase that phosphorylates MYL2 in vitro (By similarity). Increases cardiomyocyte contractility (By similarity). Required for sarcomere formation in the developing heart.
messages: Phosphorylated on serine residues.

7955:palm1a
gene id: 7955:palm1a
uniprot id: A0A8M2B2U8
uniprot id: A0A8M9PUW4
uniprot id: E9QIM7
uniprot id: Q568R7
names: Similarity
messages: Belongs to the paralemmin family.

7955:si:dkey-88i8.2
gene id: 7955:si:dkey-88i8.2
uniprot id: A0A8M9Q2R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

7955:trh
gene id: 7955:trh
uniprot id: Q5EDF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRH family.
messages: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
messages: Secreted

7955:ctsba
gene id: 7955:ctsba
uniprot id: Q6PH75
names: Similarity
messages: Belongs to the peptidase C1 family.

7955:LOC100333482
gene id: 7955:LOC100333482
uniprot id: H9GXN3
names: Similarity
messages: Belongs to the TPPP family.

7955:thbs2b
gene id: 7955:thbs2b
uniprot id: A0A8M3B7K3
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC100330229
gene id: 7955:LOC100330229
uniprot id: A0A8M9PZK9
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

7955:ogdha
gene id: 7955:ogdha
uniprot id: A0A0R4IP01
uniprot id: A0A8M2BJT5
uniprot id: A0A8M3AVG6
uniprot id: B8JI08
uniprot id: F1Q5B8
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

7955:reep5
gene id: 7955:reep5
uniprot id: Q6PBX9
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 60% of embryos die 7 days post-fertilization (PubMed:32075961). Embryos have cardiac developmental defects including a lack of cardiac looping and atrio-ventricular conduction defects with dysynchronous beating rhythms (PubMed:32075961). Increase in RTN4 protein expression levels (PubMed:32075961). Morpholino knockdown causes apparent sarcoplasmic reticulum membrane vacuolization in ventricular tissue along with structural discontinuity between sarcomeres (PubMed:32075961).
messages: Belongs to the DP1 family.
messages: Endoplasmic reticulum membrane
messages: Expressed in embryos 48 to 96 hours post-fertilization (at protein level) (PubMed:32075961). Expressed in both ventricular and atrial cardiomyocytes (at protein level) (PubMed:32075961).
messages: Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes.
messages: Sarcoplasmic reticulum membrane
messages: The short lumenal loops between transmembrane domains 1 and 2 and between transmembrane domains 3 and 4 may impart a wedge-like configuration, thus deforming membranes.

7955:itga4
gene id: 7955:itga4
uniprot id: A0A0R4ICS1
uniprot id: A0A8M9Q587
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

7955:lft1
gene id: 7955:lft1
uniprot id: Q9PW55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

7955:slc27a2b
gene id: 7955:slc27a2b
uniprot id: F6NGD6
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

7955:pcdh1g1
gene id: 7955:pcdh1g1
uniprot id: I6LC07
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

7955:ponzr2
gene id: 7955:ponzr2
uniprot id: E7F6S4
names: Similarity
messages: Belongs to the cornifelin family.

7955:mpp2b
gene id: 7955:mpp2b
uniprot id: A0A8M2B2Q1
uniprot id: A0A8M3AY34
uniprot id: A0A8M3BE13
uniprot id: Q6GMI2
names: Similarity
messages: Belongs to the MAGUK family.

7955:arid5b
gene id: 7955:arid5b
uniprot id: A0A8M6Z9G4
names: Similarity
messages: Belongs to the ARID5B family.

7955:crygm2d7
gene id: 7955:crygm2d7
uniprot id: Q15I82
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:slc8a2b
gene id: 7955:slc8a2b
uniprot id: A0A8M3AIS0
uniprot id: B2CZC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

7955:ggact.1
gene id: 7955:ggact.1
uniprot id: A0JMM9
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: May contribute to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine.

7955:grinaa
gene id: 7955:grinaa
uniprot id: Q1ECY6
names: Subcellular Location Annotation
messages: Membrane

7955:LOC100537771
gene id: 7955:LOC100537771
uniprot id: A0A8M1RPE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

7955:foxa3
gene id: 7955:foxa3
uniprot id: O73778
names: Subcellular Location Annotation
messages: Nucleus

7955:poll
gene id: 7955:poll
uniprot id: Q6P0S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Nucleus

7955:rer1
gene id: 7955:rer1
uniprot id: A0A8M2BER0
uniprot id: Q6PE45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane

7955:tuba4l
gene id: 7955:tuba4l
uniprot id: Q6TGS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

7955:rhbdd3
gene id: 7955:rhbdd3
uniprot id: A5PMS4
names: Subcellular Location Annotation
messages: Membrane

7955:vgll4b
gene id: 7955:vgll4b
uniprot id: Q6NV03
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

7955:egr2a
gene id: 7955:egr2a
uniprot id: A0A8M9PE40
uniprot id: E7F266
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

7955:ing5b
gene id: 7955:ing5b
uniprot id: A0A8M2BIJ2
uniprot id: Q6AXK3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

7955:ugt5e1
gene id: 7955:ugt5e1
uniprot id: A0A8M2BET4
uniprot id: B0S5H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7955:smyhc3
gene id: 7955:smyhc3
uniprot id: B6IDE0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:LOC103909069
gene id: 7955:LOC103909069
uniprot id: A0A8M3ARL0
names: Similarity
messages: Belongs to the peptidase C48 family.

7955:gpib
gene id: 7955:gpib
uniprot id: Q0IJ39
names: Similarity
messages: Belongs to the GPI family.

7955:myf6
gene id: 7955:myf6
uniprot id: B3DK75
uniprot id: Q6VNZ9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity).
messages: Nucleus

7955:taar13e
gene id: 7955:taar13e
uniprot id: Q5QNP8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:creb3l2
gene id: 7955:creb3l2
uniprot id: A1L224
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. ATF subfamily.
messages: Binds DNA as a dimer.
messages: Endoplasmic reticulum membrane
messages: Nucleus
messages: Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/mbtps1 and S2P/mbtps2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis. May protect neuroblastoma cells from ER stress-induced death. In vitro activates transcription of target genes via direct binding to the CRE site.
messages: Upon ER stress, translocated to the Golgi apparatus, where it is processed by regulated intramembrane proteolysis (RIP) to release the cytosol-facing N-terminal transcription factor domain. The cleavage is performed sequentially by site-1 and site-2 proteases (S1P/mbtps1 and S2P/mbtps2).

7955:ubn2a
gene id: 7955:ubn2a
uniprot id: A1L1Q5
uniprot id: I3ISA2
names: Similarity
messages: Belongs to the ubinuclein family.

7955:trpc4b
gene id: 7955:trpc4b
uniprot id: A0A0R4IM91
uniprot id: U3N7D8
names: Subcellular Location Annotation
messages: Membrane

7955:fam234b
gene id: 7955:fam234b
uniprot id: A0A8M2BIW2
names: Similarity
messages: Belongs to the FAM234 family.

7955:otpb
gene id: 7955:otpb
uniprot id: B0S6A5
uniprot id: Q6DGH9
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Characteristic of the fish lineage.
messages: Involved in the specification of isotocin cells. Required for the specification of dopaminergic neurons in the developing hypothalamus and posterior tuberculum.
messages: Isoform 1 and isoform 2 are expressed during embryonic development. At 16 hpf, expressed in a few cells in the ventral dieencephalon. At 48 hpf, present in the preoptic area and ventral hypothalamus (at protein level).
messages: Isoform 1 and isoform 2 are expressed in brain and testis.
messages: Nucleus

7955:si:dkey-190g6.2
gene id: 7955:si:dkey-190g6.2
uniprot id: E9QFB6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

7955:nrcama
gene id: 7955:nrcama
uniprot id: A0A8M2BBS1
uniprot id: A0A8M2BBY8
uniprot id: A0A8M2BC02
uniprot id: A0A8M3AR93
uniprot id: A0A8M3ARH2
uniprot id: A0A8M3ARH6
uniprot id: A0A8M3AYL8
uniprot id: A0A8M3B1K5
uniprot id: A0A8M3B1K8
uniprot id: A0A8M3B8T9
uniprot id: A0A8M3B8U0
uniprot id: A0A8M9PH88
uniprot id: A0A8M9PUF4
uniprot id: A0A8M9Q5W3
uniprot id: A0A8M9QB75
uniprot id: Q5TYT1
names: Similarity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

7955:hcar1-1
gene id: 7955:hcar1-1
uniprot id: C6EVZ7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:prkci
gene id: 7955:prkci
uniprot id: Q6DI53
uniprot id: Q90XF2
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway (By similarity). Is required for the formation and maintenance of the zonula adherens during early epithelial development and plays a critical role in organ morphogenesis and in regulating the orientation of cell division.
messages: Exhibits an elevated basal enzymatic activity and is not regulated by diacylglycerol, phosphatidylserine, phorbol esters or calcium ions. Two specific sites, Thr-404 (activation loop of the kinase domain) and Thr-556 (turn motif), need to be phosphorylated for its full activation (By similarity).
messages: It is uncertain whether Met-1 or Met-9 is the initiator.
messages: The C1 zinc finger does not bind the diacylglycerol (DAG).

7955:trnt1
gene id: 7955:trnt1
uniprot id: F6NXI9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
messages: Cytoplasm
messages: Expressed from early embryogenesis (PubMed:26494905). By 2 days post-fertilization (dpf), enriched in the brain, cardiovascular region, pectoral fin buds and in proliferative cells of the retina (PubMed:26494905). At 3 dpf, expression is maintained in the brain, retina and cardiac regions (PubMed:26494905). By 5 dpf, expression is observed in the head and trunk neuromasts (PubMed:26494905).
messages: Expressed ubiquitously during early embryogenesis.
messages: Fishes develop normally for the first 4 days as they can rely on maternal transcripts present in the fertilised egg, but they all die of multisystem defects by nine days post-fertilization (dpf).
messages: Mitochondrion
messages: Monomer, and homodimer.
messages: Nucleotidyltransferase that catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs, which is necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates (PubMed:26494905). tRNA 3'-terminal CCA addition is required both for tRNA processing and repair (By similarity). Promotes tRNA repair and recycling downstream of the ribosome-associated quality control (RQC) pathway by mediating addition of the tRNA 3'-terminal CCA following cleavage by ankzf1 and repair by elac1 (By similarity). Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs and tRNA-like transcripts (By similarity). While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs beginning with GG are marked with CCACCA and rapidly degraded (By similarity). The structural flexibility of RNA controls the choice between CCA versus CCACCA addition: following the first CCA addition cycle, nucleotide-binding to the active site triggers a clockwise screw motion, producing torque on the RNA (By similarity). This ejects stable RNAs, whereas unstable RNAs are refolded while bound to the enzyme and subjected to a second CCA catalytic cycle (By similarity).
messages: Nucleus

7955:crhb
gene id: 7955:crhb
uniprot id: Q5U3N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

7955:zgc:171711
gene id: 7955:zgc:171711
uniprot id: A7YY07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SHFL family.
messages: Cytoplasm
messages: Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses and cellular genes. Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site. May exhibit antiviral activity.
messages: Nucleus
messages: P-body

7955:fggy
gene id: 7955:fggy
uniprot id: Q6NUW9
names: Similarity
messages: Belongs to the FGGY kinase family.

7955:ap1s3a
gene id: 7955:ap1s3a
uniprot id: A0A8M3AQ70
uniprot id: A0A8M3AT20
uniprot id: A0A8M9Q0D2
uniprot id: Q567B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

7955:LOC110437777
gene id: 7955:LOC110437777
uniprot id: A0A8M9QN60
uniprot id: F1QFQ7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

7955:casp6l2
gene id: 7955:casp6l2
uniprot id: A0A8M6Z4Y1
uniprot id: Q29R92
names: Similarity
messages: Belongs to the peptidase C14A family.

7955:zgc:153924
gene id: 7955:zgc:153924
uniprot id: Q08BZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

7955:hsf4
gene id: 7955:hsf4
uniprot id: A0A8M3AJJ3
uniprot id: A0A8M9PQ64
uniprot id: Q5CZP2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the HSF family.
messages: Expression in the ocular lens starts at as early as 24 hours post fertilization (hpf).
messages: Heat-shock transcription factor that specifically binds heat shock promoter elements (HSE) (PubMed:22528049). Required for denucleation and organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light (PubMed:32061775, PubMed:33854238). In this process, may regulate denucleation of lens fiber cells in part by activating dnase1l1l and dnase2b transcription (PubMed:32061775). May be involved in DNA repair through the transcriptional regulation of rad51 (PubMed:22587838). May up-regulate TP53 protein in lens fiber cells, possibly through protein stabilization (PubMed:28981088). In the eye lens, controls the expression of alpha-crystallin B chain/CRYAB and consequently may be involved in the regulation of lysosomal acidification (PubMed:31786107).
messages: In knockout animals, the eye lens grows normally, but during lens differentiation, denucleation is impaired and the degradation of mitochondria and endoplasmic reticulum is suppressed.
messages: Nucleus
messages: Predominantly expressed in the eye.

7955:vps26b
gene id: 7955:vps26b
uniprot id: A0A2R8Q1X8
uniprot id: Q7ZV03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity).
messages: Belongs to the VPS26 family.
messages: Component of the heterotrimeric retromer cargo-selective complex (CSC) which is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants (By similarity).
messages: Cytoplasm
messages: Endosome
messages: Membrane

7955:dcn
gene id: 7955:dcn
uniprot id: Q803T1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.
messages: May affect the rate of fibrils formation.
messages: extracellular matrix

7955:ppp3cca
gene id: 7955:ppp3cca
uniprot id: A0A286YA34
uniprot id: A3KGZ6
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

7955:rpain
gene id: 7955:rpain
uniprot id: F1QKJ6
uniprot id: Q0P498
names: Subcellular Location Annotation
messages: Nucleus

7955:depdc7
gene id: 7955:depdc7
uniprot id: Q1JQ19
names: Similarity
messages: Belongs to the DEPDC7 family.

7955:mtf2
gene id: 7955:mtf2
uniprot id: Q1JQ07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

7955:LOC556339
gene id: 7955:LOC556339
uniprot id: A0A8M9Q118
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

7955:dse
gene id: 7955:dse
uniprot id: Q5RGL8
names: Similarity
messages: Belongs to the dermatan-sulfate isomerase family.

7955:si:ch73-209e20.5
gene id: 7955:si:ch73-209e20.5
uniprot id: A0A8M9PQU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel flower family.
messages: Membrane

7955:abcc10
gene id: 7955:abcc10
uniprot id: A0A8M9PSA7
names: Subcellular Location Annotation
messages: Membrane

7955:herpud2
gene id: 7955:herpud2
uniprot id: Q6NYI0
names: Function
names: Subcellular Location Annotation
messages: Could be involved in the unfolded protein response (UPR) pathway.
messages: Membrane

7955:si:dkey-119f1.1
gene id: 7955:si:dkey-119f1.1
uniprot id: A0A8M1NHD0
names: Subcellular Location Annotation
messages: Chromosome

7955:iah1
gene id: 7955:iah1
uniprot id: B7ZVA4
uniprot id: Q503L4
names: Function
names: Similarity
messages: Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.
messages: Probable lipase.

7955:tmem184bb
gene id: 7955:tmem184bb
uniprot id: A0A0R4IXB8
names: Subcellular Location Annotation
messages: Membrane

7955:tcf7
gene id: 7955:tcf7
uniprot id: Q5PU93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

7955:pax8
gene id: 7955:pax8
uniprot id: A0A8M6Z787
uniprot id: A0A8M9PZA2
uniprot id: F1Q9Q9
names: Subcellular Location Annotation
messages: Nucleus

7955:psmd4a
gene id: 7955:psmd4a
uniprot id: Q6IQC6
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

7955:opa3
gene id: 7955:opa3
uniprot id: Q1L9A2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OPA3 family.
messages: May play some role in mitochondrial processes.
messages: Mitochondrion

7955:serpine2
gene id: 7955:serpine2
uniprot id: Q7ZVL5
names: Similarity
messages: Belongs to the serpin family.

7955:cyr61l2
gene id: 7955:cyr61l2
uniprot id: A0A0R4IXA2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:vcam1a
gene id: 7955:vcam1a
uniprot id: F6NRL9
names: Subcellular Location Annotation
messages: Membrane

7955:shmt2
gene id: 7955:shmt2
uniprot id: A9LDD9
names: Similarity
messages: Belongs to the SHMT family.

7955:pde1cb
gene id: 7955:pde1cb
uniprot id: A0A8M1RN98
uniprot id: A0A8M3B7Y8
uniprot id: A0A8M6YUN9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

7955:ogfrl2
gene id: 7955:ogfrl2
uniprot id: Q08CQ7
names: Similarity
messages: Belongs to the opioid growth factor receptor family.

7955:ugt2a6
gene id: 7955:ugt2a6
uniprot id: B8JMA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7955:si:dkey-163m14.6
gene id: 7955:si:dkey-163m14.6
uniprot id: A0A8M9PD22
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:gna12a
gene id: 7955:gna12a
uniprot id: Q5YKG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

7955:mlec
gene id: 7955:mlec
uniprot id: A9C3P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the malectin family.
messages: Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity).
messages: Endoplasmic reticulum membrane

7955:si:ch211-244c8.4
gene id: 7955:si:ch211-244c8.4
uniprot id: A0A0R4IT13
names: Similarity
messages: Belongs to the Amer family.

7955:LOC103911912
gene id: 7955:LOC103911912
uniprot id: A0A8M3AYE6
uniprot id: A0A8M9PX05
uniprot id: A0A8M9QJ51
names: Subcellular Location Annotation
messages: Membrane

7955:rbm42
gene id: 7955:rbm42
uniprot id: A0A0R4I9C3
uniprot id: Q6DRG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM RBM42 family.
messages: Cytoplasm
messages: May bind RNA.
messages: Nucleus

7955:trpm1b
gene id: 7955:trpm1b
uniprot id: A0A8M9P6H0
uniprot id: A0A8M9PV08
uniprot id: A3KNP8
names: Subcellular Location Annotation
messages: Membrane

7955:c18h15orf65
gene id: 7955:c18h15orf65
uniprot id: A0A8M9P176
names: Subcellular Location Annotation
messages: cilium axoneme

7955:slc6a15
gene id: 7955:slc6a15
uniprot id: Q1LVQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:LOC100334604
gene id: 7955:LOC100334604
uniprot id: A0A0G2KWZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

7955:ppp3ccb
gene id: 7955:ppp3ccb
uniprot id: A0A8M2B1V9
uniprot id: A0A8M2B273
uniprot id: A1L277
uniprot id: F1QF86
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

7955:tmem91
gene id: 7955:tmem91
uniprot id: A0A8M3AKK5
uniprot id: A0A8M9PPP4
names: Similarity
messages: Belongs to the CD225/Dispanin family.

7955:c10h21orf59
gene id: 7955:c10h21orf59
uniprot id: B7ZVU8
uniprot id: Q6DRC3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CFAP298 family.
messages: Cytoplasm
messages: Detected at the 1-cell embryo stage, probably due to inheritance of maternal transcripts. At the 50% ebiboly stage, detected in dorsal forerunner cells. At the 3-somite stage, found in Kupffer's vesicle. At the 8-somite stage, expressed in the pronephros, the floorplate of the neural tube, and otic vesicles. Expression in the pronephros continues to the 24-somite stage.
messages: Interacts with dnaaf1/swt. Interacts with lrrc6/sea. Interacts with dvl (via DEP and PDZ domains).
messages: Larval lethal (PubMed:26904945). Animals show strong ciliopathy phenotypes, including pronephric cysts, axis curvature, left-right asymmetry defects and hydrocephalus (PubMed:26904945). Kidney tubules are dilated and polarity of cilia in the epithelium is disorganized (PubMed:26904945). Cilia length and number appear normal, but outer dynein arms are missing and cilia are paralyzed (PubMed:26904945). Morpholino knockdown of the protein results in similar phenotypes (PubMed:24094744, PubMed:26904945).
messages: Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly (PubMed:24094744, PubMed:26904945). Seems to be important for initiation rather than maintenance of cilium motility (PubMed:26904945). Required for correct positioning of cilia at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway (PubMed:26904945). May suppress canonical Wnt signaling activity (PubMed:26904945).
messages: Strongly expressed in ciliated tissues of the embryonic trunk, including the pronephric ducts and spinal canal.
messages: cilium basal body

7955:alms1
gene id: 7955:alms1
uniprot id: F1QF92
names: Subcellular Location Annotation
messages: centrosome

7955:chrm3a
gene id: 7955:chrm3a
uniprot id: A0A8M9PNY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

7955:nsun4
gene id: 7955:nsun4
uniprot id: A0A8M9Q8A2
uniprot id: Q5PRB6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

7955:sub1a
gene id: 7955:sub1a
uniprot id: Q504B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcriptional coactivator PC4 family.
messages: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
messages: Nucleus

7955:slc34a2a
gene id: 7955:slc34a2a
uniprot id: Q9PTQ8
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

7955:myh14
gene id: 7955:myh14
uniprot id: A0A8M2B482
uniprot id: A0A8M2B4A6
uniprot id: A0A8M3AHY4
uniprot id: A0A8M3AJ07
uniprot id: A0A8M3AQG4
uniprot id: A0A8M3B1K3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:borcs5
gene id: 7955:borcs5
uniprot id: A0A2R8PVF5
uniprot id: Q5XIX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As part of a BORC-like complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, this complex may couple lysosomes to microtubule plus-end-directed kinesin motor.
messages: Belongs to the BORCS5 family.
messages: Lysosome membrane
messages: Membrane

7955:ephb3a
gene id: 7955:ephb3a
uniprot id: A0A8M6Z0S5
uniprot id: Q90ZN8
names: Subcellular Location Annotation
messages: Membrane

7955:sbf2
gene id: 7955:sbf2
uniprot id: A0A2R8PXC7
uniprot id: A0A8M9QI58
uniprot id: E7F4G2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

7955:large
gene id: 7955:large
uniprot id: Q66PG2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity. Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide. Requires the phosphorylation of core M3 (O-mannosyl trisaccharide) by POMK to elongate the glucuronyl-beta-1,4-xylose-beta disaccharide primer (By similarity). Plays a key role in skeletal muscle function and regeneration (By similarity).
messages: Binds 2 Mn(2+) ions per subunit. The xylosyltransferase part binds one Mn(2+) and the beta-1,3-glucuronyltransferase part binds one Mn(2+).
messages: Golgi apparatus membrane
messages: In the C-terminal section; belongs to the glycosyltransferase 49 family.
messages: In the N-terminal section; belongs to the glycosyltransferase 8 family.

7955:tpma
gene id: 7955:tpma
uniprot id: P13104
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tropomyosin family.
messages: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
messages: Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain.
messages: The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
messages: cytoskeleton

7955:si:ch1073-70f20.1
gene id: 7955:si:ch1073-70f20.1
uniprot id: A0A8M1PZ50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

7955:LOC101885160
gene id: 7955:LOC101885160
uniprot id: E7F718
names: Subcellular Location Annotation
messages: Secreted

7955:pttg1
gene id: 7955:pttg1
uniprot id: B8A4J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

7955:lbh
gene id: 7955:lbh
uniprot id: Q7SXH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LBH family.
messages: Cytoplasm
messages: Nucleus
messages: Transcriptional activator.

7955:gngt1
gene id: 7955:gngt1
uniprot id: Q6PBN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

7955:s1pr3a
gene id: 7955:s1pr3a
uniprot id: A0A8M1NC80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:ucp3
gene id: 7955:ucp3
uniprot id: A8KC25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7955:epha2a
gene id: 7955:epha2a
uniprot id: Q6NZS1
names: Subcellular Location Annotation
messages: Membrane

7955:yeats4
gene id: 7955:yeats4
uniprot id: Q6DGB4
names: Subcellular Location Annotation
messages: Nucleus

7955:stxbp5a
gene id: 7955:stxbp5a
uniprot id: A0A8M3AKV9
uniprot id: A0A8M3ALK2
uniprot id: A0A8M3B457
uniprot id: A0A8M9PHB6
uniprot id: Q5RGD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

7955:pcsk5a
gene id: 7955:pcsk5a
uniprot id: A0A8M9Q4U3
names: Caution
names: Similarity
messages: Belongs to the peptidase S8 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:actr8
gene id: 7955:actr8
uniprot id: P59679
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP8 subfamily.
messages: Chromosome
messages: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core (By similarity).
messages: Nucleus
messages: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity).
messages: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex (By similarity).

7955:arid3a
gene id: 7955:arid3a
uniprot id: A0A0N4STX9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer.
messages: Nucleus
messages: Transcription factor.

7955:si:ch211-197g15.8
gene id: 7955:si:ch211-197g15.8
uniprot id: A0A8M1RFT6
names: Similarity
messages: Belongs to the IFI44 family.

7955:v2rh9
gene id: 7955:v2rh9
uniprot id: A0A8M1Q183
uniprot id: A0A8M3AV08
uniprot id: A0A8M6YW75
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:slf2
gene id: 7955:slf2
uniprot id: A0A8M1RDX3
uniprot id: A0A8M2B2M7
uniprot id: F1QB81
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM178 family.
messages: Nucleus
messages: Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions.
messages: Slf2 depletion in zebrafish embryos using CRISPR/Cas9-mediated genome editing or morpholino gene knockdown results in a significant reduction in head size and aberrant craniofacial patterning in the pharyngeal skeleton.

7955:tspan15
gene id: 7955:tspan15
uniprot id: Q568D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7955:kdm5c
gene id: 7955:kdm5c
uniprot id: A0A8M6Z830
uniprot id: B0S6L0
names: Similarity
messages: Belongs to the JARID1 histone demethylase family.

7955:cx35.4
gene id: 7955:cx35.4
uniprot id: Q567J2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: gap junction

7955:si:dkey-211g8.4
gene id: 7955:si:dkey-211g8.4
uniprot id: Q1L957
names: Subcellular Location Annotation
messages: Nucleus

7955:zgc:110348
gene id: 7955:zgc:110348
uniprot id: B0S7C9
uniprot id: Q568E4
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

7955:olfcd1
gene id: 7955:olfcd1
uniprot id: A0A8M3AS21
uniprot id: A0A8M9PAH3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:si:dkey-180p18.9
gene id: 7955:si:dkey-180p18.9
uniprot id: Q1JPZ2
names: Similarity
messages: Belongs to the aldo/keto reductase family.

7955:usp21
gene id: 7955:usp21
uniprot id: A0A8M2B8Z0
uniprot id: E9QFQ5
names: Similarity
messages: Belongs to the peptidase C19 family.

7955:sort1a
gene id: 7955:sort1a
uniprot id: Q6NUT7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS10-related sortilin family. SORT1 subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. May also mediate transport from the endoplasmic reticulum to the Golgi.
messages: Golgi stack membrane
messages: Interacts with the cytosolic adapter proteins GGA1 and GGA2. Interacts with the heterotrimeric retromer cargo-selective complex (CSC), also described as vacuolar protein sorting subcomplex (VPS), formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35; which is involved in retrograde trafficking of the receptor from endosomes to the Golgi apparatus (By similarity).
messages: Lysosome membrane
messages: Nucleus membrane
messages: Palmitoylated. Undergoes cysteine S-palmitoylation which promotes the partitioning of the receptor into an endosomal membrane subdomain where it can interact with the retromer cargo-selective complex which mediates its retrograde trafficking to the Golgi apparatus.

7955:mtcl1
gene id: 7955:mtcl1
uniprot id: A0A8M2BIS7
uniprot id: A0A8M6YUR8
uniprot id: A0A8M6YWL4
uniprot id: A0A8M6Z2L9
uniprot id: A0A8M6Z384
names: Similarity
messages: Belongs to the SOGA family.

7955:rdh12
gene id: 7955:rdh12
uniprot id: Q6DG78
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:ddr2b
gene id: 7955:ddr2b
uniprot id: A0A8M6Z131
names: Subcellular Location Annotation
messages: Membrane

7955:zgc:110626
gene id: 7955:zgc:110626
uniprot id: Q567Z4
names: Similarity
messages: Belongs to the arrestin family.

7955:slc6a6b
gene id: 7955:slc6a6b
uniprot id: Q2VRP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.
messages: Cell membrane
messages: Membrane

7955:usp1
gene id: 7955:usp1
uniprot id: Q7ZVK6
names: Similarity
messages: Belongs to the peptidase C19 family.

7955:LOC556532
gene id: 7955:LOC556532
uniprot id: A0A8M9PE56
uniprot id: A0A8M9PLA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:LOC100332250
gene id: 7955:LOC100332250
uniprot id: A0A8M1RRM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

7955:cacnb2a
gene id: 7955:cacnb2a
uniprot id: A2SZ54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: sarcolemma

7955:si:dkey-14d8.7
gene id: 7955:si:dkey-14d8.7
uniprot id: Q5RHW3
names: Similarity
messages: Belongs to the dermatopontin family.

7955:dolpp1
gene id: 7955:dolpp1
uniprot id: Q5XJT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.

7955:edil3a
gene id: 7955:edil3a
uniprot id: A0A0R4IMA9
uniprot id: A0A2R8QA02
uniprot id: A0A8M2BCH2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:zgc:100906
gene id: 7955:zgc:100906
uniprot id: Q6DEI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

7955:zgc:91818
gene id: 7955:zgc:91818
uniprot id: Q6DGA3
names: Similarity
messages: Belongs to the RAMP family.

7955:rgmb
gene id: 7955:rgmb
uniprot id: Q6IYD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

7955:p2rx8
gene id: 7955:p2rx8
uniprot id: Q7SZM1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

7955:cth
gene id: 7955:cth
uniprot id: F1QPF7
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

7955:tnfaip8l2a
gene id: 7955:tnfaip8l2a
uniprot id: Q1ECV8
names: Domain
names: Function
names: Similarity
messages: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits jun/ap1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity).
messages: Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.
messages: The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding (By similarity).

7955:tnk2b
gene id: 7955:tnk2b
uniprot id: A0A0R4IH27
uniprot id: A0A8M2BAU8
uniprot id: A0A8M9PXR5
uniprot id: A0A8M9QFB3
uniprot id: A0A8M9QJL9
uniprot id: A0A8M9QNC5
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

7955:cyp1a
gene id: 7955:cyp1a
uniprot id: Q8UW07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

7955:rorca
gene id: 7955:rorca
uniprot id: A3R3K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

7955:ralbb
gene id: 7955:ralbb
uniprot id: Q6IQE6
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

7955:il17d
gene id: 7955:il17d
uniprot id: Q5TKT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

7955:dnm2b
gene id: 7955:dnm2b
uniprot id: Q6P122
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

7955:smg9
gene id: 7955:smg9
uniprot id: E7F7F6
names: Similarity
messages: Belongs to the SMG9 family.

7955:ahr1b
gene id: 7955:ahr1b
uniprot id: Q4U3K9
names: Subcellular Location Annotation
messages: Cytoplasm

7955:slc11a2
gene id: 7955:slc11a2
uniprot id: Q1RLY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

7955:clgn
gene id: 7955:clgn
uniprot id: A0A8M2B772
uniprot id: Q08BY9
names: Similarity
messages: Belongs to the calreticulin family.

7955:zgc:171579
gene id: 7955:zgc:171579
uniprot id: A8WFU2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:tmem41b
gene id: 7955:tmem41b
uniprot id: A1A5V7
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Endomembrane system
messages: Endoplasmic reticulum membrane
messages: Morpholino knockdown of the protein causes severe defects in motor neuron axonal outgrowth.
messages: Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes. Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine. Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by atg2 (atg2a or atg2b) to mediate autophagosome assembly. In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (By similarity). Required for normal motor neuron development (PubMed:23063131).
messages: The VTT domain was previously called the SNARE-assoc domain. As there is no evidence that this domain associates with SNARE proteins, it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.

7955:iws1
gene id: 7955:iws1
uniprot id: A0A8M1RRH3
uniprot id: A0A8M2B439
uniprot id: A0A8M2B469
uniprot id: A0A8M6YSM7
uniprot id: A0A8M9PIW9
names: Subcellular Location Annotation
messages: Nucleus

7955:LOC101883368
gene id: 7955:LOC101883368
uniprot id: A0A8M2BIZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

7955:calcr
gene id: 7955:calcr
uniprot id: A0A8M9PPS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Membrane

7955:slc30a7
gene id: 7955:slc30a7
uniprot id: A5PMX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Cytoplasmic vesicle
messages: Golgi apparatus membrane
messages: Homooligomer.
messages: Mitochondrion
messages: Sarcoplasmic reticulum
messages: Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway. By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases.
messages: trans-Golgi network

7955:srsf1a
gene id: 7955:srsf1a
uniprot id: Q7SXP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: May play a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing.
messages: Nucleus

7955:grm1b
gene id: 7955:grm1b
uniprot id: A0A0R4IU63
uniprot id: A0A8M3AJM0
uniprot id: U3N6H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

7955:cops2
gene id: 7955:cops2
uniprot id: Q6IQT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN2 family.
messages: Component of the CSN complex, probably composed of cops1, cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
messages: Cytoplasm
messages: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity.
messages: Nucleus

7955:b3gnt5a
gene id: 7955:b3gnt5a
uniprot id: Q7T3S5
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids.
messages: Expressed in 2 distinct phases during the embryogenesis. The early phase extends from late blastulation to the completion of epiboly, during which the expression occurs in the superficial layer of the embryos. The second phase of expression starts during mid-segmentation and persists until day 3, during which the expression occurs prominently in the developing lens.
messages: Golgi apparatus membrane
messages: Hedgehog signaling is required for expression in embryonic lens.

7955:noc3l
gene id: 7955:noc3l
uniprot id: Q6DRN3
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: Contaminating sequence. Potential poly-A sequence.
messages: nucleolus

7955:vdrb
gene id: 7955:vdrb
uniprot id: Q1L673
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Cytoplasm
messages: Detected in embryo 24 to 48 hours after fertilization, and in intestinal bulb.
messages: Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding (By similarity). Interacts with ncoa1 and possibly other coactivators, leading to a strong increase of transcription of target genes (By similarity).
messages: Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

7955:aldh8a1
gene id: 7955:aldh8a1
uniprot id: A9YD19
uniprot id: Q66I21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aldehyde dehydrogenase family.
messages: Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation.
messages: Cytoplasm

7955:pithd1
gene id: 7955:pithd1
uniprot id: Q6NYX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PITHD1 family.
messages: Cytoplasm
messages: May play a role in promoting megakaryocyte differentiation by up-regulating RUNX1 expression.

7955:efna1b
gene id: 7955:efna1b
uniprot id: O93431
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:gatad2ab
gene id: 7955:gatad2ab
uniprot id: A0A0R4IN87
uniprot id: A0A2R8QD88
uniprot id: A0A8M2BHR2
uniprot id: A0A8M2BHS0
uniprot id: A0A8M2BHS5
uniprot id: Q6NW66
names: Subcellular Location Annotation
messages: Nucleus

7955:pds5b
gene id: 7955:pds5b
uniprot id: A0A0R4IP12
names: Subcellular Location Annotation
messages: Nucleus

7955:LOC108191961
gene id: 7955:LOC108191961
uniprot id: A0A8M6Z3Z8
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

7955:hoxb8a
gene id: 7955:hoxb8a
uniprot id: A0A8M2BJC8
uniprot id: Q8AWZ0
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: At the 10-somite stage, expressed in the paraxial mesoderm with an anterior expression limit at somite 6. At the 20-somite stage, expressed in the developing CNS with an anterior expression limit adjacent to the somite 3/somite 4 boundary; also expressed in bilateral domains adjacent to the anterior spinal cord and ventrally along the trunk in the pronephric ducts.
messages: Belongs to the Antp homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

7955:fgd4b
gene id: 7955:fgd4b
uniprot id: A0A8M1PU37
uniprot id: E7EYW1
names: Subcellular Location Annotation
messages: cytoskeleton

7955:LOC794598
gene id: 7955:LOC794598
uniprot id: A0A8M1PYW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

7955:zmp:0000001236
gene id: 7955:zmp:0000001236
uniprot id: A0A8M1RIA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mastermind family.
messages: Nucleus speckle

7955:vps51
gene id: 7955:vps51
uniprot id: Q155U0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the VPS51 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex Component of the endosome-associated retrograde protein (EARP) complex.
messages: Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy (PubMed:16581006). Acts as component of the EARP complex that is involved in endocytic recycling (By similarity).
messages: Larvae are morphologically indistinguishable from wild-type sibling larvae, but their absorption of lipids is severely impaired.
messages: Recycling endosome
messages: Ubiquitously expressed in adult.
messages: trans-Golgi network

7955:csk
gene id: 7955:csk
uniprot id: A0JMN4
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

7955:gla
gene id: 7955:gla
uniprot id: F1Q5G5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

7955:mrpl53
gene id: 7955:mrpl53
uniprot id: Q66I54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL53 family.
messages: Mitochondrion

7955:ntrk3a
gene id: 7955:ntrk3a
uniprot id: F1QKJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

7955:ptbp1a
gene id: 7955:ptbp1a
uniprot id: A0A8M9QFQ9
uniprot id: Q503D3
names: Subcellular Location Annotation
messages: Nucleus

7955:LOC568110
gene id: 7955:LOC568110
uniprot id: E7FBM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

7955:cmklr1
gene id: 7955:cmklr1
uniprot id: A2BGL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

7955:cpne7
gene id: 7955:cpne7
uniprot id: A0A8M6Z7F3
uniprot id: E7F725
names: Similarity
messages: Belongs to the copine family.

7955:trpm4b.1
gene id: 7955:trpm4b.1
uniprot id: A0A8M3AY04
uniprot id: A0A8M3B774
uniprot id: A0A8M9QIY9
names: Subcellular Location Annotation
messages: Membrane

7955:LOC110440067
gene id: 7955:LOC110440067
uniprot id: A0A8M9QCC5
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.

7955:gcnt7
gene id: 7955:gcnt7
uniprot id: A0A8M2BG25
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

7955:LOC564253
gene id: 7955:LOC564253
uniprot id: A0A8M3B4P2
uniprot id: A0A8M3B7H5
names: Subcellular Location Annotation
messages: Cytoplasm

7955:recql
gene id: 7955:recql
uniprot id: A0A8M9PHB7
uniprot id: Q498Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

7955:atp6v1d
gene id: 7955:atp6v1d
uniprot id: Q7ZVX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase D subunit family.
messages: clathrin-coated vesicle membrane

7955:wnt5a
gene id: 7955:wnt5a
uniprot id: A1BPR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

7955:zgc:66455
gene id: 7955:zgc:66455
uniprot id: Q7SXC1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:skilb
gene id: 7955:skilb
uniprot id: B3DGU8
uniprot id: E7FGJ1
names: Similarity
messages: Belongs to the SKI family.

7955:trpt1
gene id: 7955:trpt1
uniprot id: Q5EAR5
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.

7955:tulp1b
gene id: 7955:tulp1b
uniprot id: A0A8M9PNC0
names: Similarity
messages: Belongs to the TUB family.

7955:ppp1cc
gene id: 7955:ppp1cc
uniprot id: A0A0R4IZT6
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.

7955:si:dkey-44g23.5
gene id: 7955:si:dkey-44g23.5
uniprot id: Q1MT54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCRIP family.
messages: Nucleus
messages: Stress granule

7955:zgc:173585
gene id: 7955:zgc:173585
uniprot id: A7E2M8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:si:ch73-281k2.5
gene id: 7955:si:ch73-281k2.5
uniprot id: A0A0R4IN59
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:mmp17b
gene id: 7955:mmp17b
uniprot id: A0A0R4IB00
uniprot id: A0A8M9PZY9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

7955:sub1b
gene id: 7955:sub1b
uniprot id: Q6DGP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcriptional coactivator PC4 family.
messages: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
messages: Nucleus

7955:tph2
gene id: 7955:tph2
uniprot id: A0A8M1P7E6
uniprot id: Q1LUE3
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

7955:foxk1
gene id: 7955:foxk1
uniprot id: Q7SYM1
names: Subcellular Location Annotation
messages: Nucleus

7955:ube2e3
gene id: 7955:ube2e3
uniprot id: B0S6A7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7955:LOC110439878
gene id: 7955:LOC110439878
uniprot id: A0A8M9PN88
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

7955:rpl5a
gene id: 7955:rpl5a
uniprot id: Q7ZUI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

7955:plcd1a
gene id: 7955:plcd1a
uniprot id: A0A0R4IGD7
uniprot id: A7MD68
names: Cofactor
messages: Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.

7955:bves
gene id: 7955:bves
uniprot id: G9HVJ5
uniprot id: Q5PQZ7
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the popeye family.
messages: Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in skeletal muscle and heart development as well as in the maintenance of heart function (PubMed:26642364). May play a role in vamp3-mediated vesicular transport and recycling of receptor molecules. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. May induce primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. May be involved in epithelial movement during corneal sheet formation and regeneration. May play a role in the regulation of cell shape and movement by modulating the Rho-GTPase activity. May also be involved in striated muscle regeneration and in the regulation of cell spreading (By similarity).
messages: Expressed in skeletal muscle (at protein level).
messages: Lateral cell membrane
messages: Membrane
messages: Morpholino knockdown of the protein causes cardiac edema in 70% of the injected morphants. They show malformed myotendinous junction and, in 80% of the morphants, skeletal muscle is characterized by myofibrillar misalignment and fiber detachment.
messages: caveola
messages: sarcolemma
messages: tight junction

7955:zgc:92907
gene id: 7955:zgc:92907
uniprot id: F1R0S3
names: Similarity
messages: Belongs to the glycosyltransferase 28 family.

7955:arhgap29b
gene id: 7955:arhgap29b
uniprot id: Q6PCS4
names: Function
messages: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42 (By similarity).

7955:laptm4b
gene id: 7955:laptm4b
uniprot id: Q801V1
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

7955:sfrp2l
gene id: 7955:sfrp2l
uniprot id: A0A8M1RMJ5
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:fam234a
gene id: 7955:fam234a
uniprot id: A0A8M1PZ20
names: Similarity
messages: Belongs to the FAM234 family.

7955:trpv1
gene id: 7955:trpv1
uniprot id: B0S711
uniprot id: B6RTA2
names: Subcellular Location Annotation
messages: Membrane

7955:cyldl
gene id: 7955:cyldl
uniprot id: E7F1X5
names: Subcellular Location Annotation
messages: centrosome
messages: perinuclear region

7955:zcchc4
gene id: 7955:zcchc4
uniprot id: A8WG80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZCCHC4 family.
messages: Cytoplasm
messages: nucleolus

7955:si:ch211-185a18.2
gene id: 7955:si:ch211-185a18.2
uniprot id: H6D7E6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALPID3 family.
messages: Homozygous for these mutant alleles complete embryogenesis normally, but manifest a cystic kidney phenotype during the early larval stages and die within a month of hatching. Elimination of maternally derived talpid3 activity by germline replacement resulted in embryonic lethality of talpid3 homozygotes. The phenotype of such maternal and zygotic mutant show absence of primary and motile cilia as well as aberrant Hedgehog signaling.
messages: Required for ciliogenesis and sonic hedgehog/SHH signaling.
messages: Ubiquitously distributed in embryos from early cleavage stages through to 2 dpf.
messages: centriole
messages: cilium basal body

7955:zgc:153409
gene id: 7955:zgc:153409
uniprot id: Q0D294
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:pigo
gene id: 7955:pigo
uniprot id: E9QI13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:si:dkey-112a7.4
gene id: 7955:si:dkey-112a7.4
uniprot id: A0A0R4IFB4
names: Similarity
messages: Belongs to the CAMK2N family.

7955:pdyn
gene id: 7955:pdyn
uniprot id: A0A8M3AYT0
uniprot id: A0A8M3B6F1
uniprot id: Q6JT77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin.
messages: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Leumorphin has a typical opioid activity and may have anti-apoptotic effect.
messages: Secreted

7955:klc1b
gene id: 7955:klc1b
uniprot id: Q7ZVT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

7955:zp2l2
gene id: 7955:zp2l2
uniprot id: A3KP56
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:npvf
gene id: 7955:npvf
uniprot id: Q1LW92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Secreted

7955:mos
gene id: 7955:mos
uniprot id: Q90YD0
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:ifih1
gene id: 7955:ifih1
uniprot id: A0A0E3D804
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

7955:tnfa
gene id: 7955:tnfa
uniprot id: Q08CQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Membrane

7955:calr3a
gene id: 7955:calr3a
uniprot id: Q6PE26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

7955:tmem70
gene id: 7955:tmem70
uniprot id: E7FGK5
names: Similarity
messages: Belongs to the TMEM70 family.

7955:LOC571410
gene id: 7955:LOC571410
uniprot id: F1QWZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:hk2
gene id: 7955:hk2
uniprot id: Q7ZVL7
names: Similarity
messages: Belongs to the hexokinase family.

7955:dzip1l
gene id: 7955:dzip1l
uniprot id: Q32PN7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DZIP C2H2-type zinc-finger protein family.
messages: Embryos show defects in otolith formation in the inner ear, but no other overt morphological changes.
messages: Involved in primary cilium formation (PubMed:28530676). Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane.
messages: Maternally expressed. Ubiquitously expressed in embryos at 1 day post-fertilization (dpf), with a more discrete accumulation in the embryonic kidneys. In developing kidney, expressed in the midsections of the pronephric ducts, in a pattern consistent with the multiciliated cells.
messages: centriole
messages: cilium basal body

7955:rpl19
gene id: 7955:rpl19
uniprot id: Q6P5L3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

7955:cdnf
gene id: 7955:cdnf
uniprot id: A4QNW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

7955:mgat2
gene id: 7955:mgat2
uniprot id: A4IG58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 16 (GT16) protein family.
messages: Golgi apparatus membrane
messages: Membrane

7955:LOC798736
gene id: 7955:LOC798736
uniprot id: A0A8M9PER5
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:alkbh1
gene id: 7955:alkbh1
uniprot id: A0A8M2B5M4
uniprot id: Q502A8
names: Cofactor
messages: Binds 1 Fe(2+) ion per subunit.

7955:ypel2a
gene id: 7955:ypel2a
uniprot id: E9QDC9
names: Similarity
messages: Belongs to the yippee family.

7955:ttc25
gene id: 7955:ttc25
uniprot id: Q7ZU45
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Plays an essential role for the assembly of ODA-DC and in the docking of ODA in ciliary axoneme.
messages: Component of the outer dynein arm-docking complex along with ODAD1, ODAD2 and ODAD3.
messages: Morpholino knockdown of the protein causes severe curvature of the body at 72 hpf. Morphants also exhibit hydrocephalus, abnormal otoliths and disturbed left-right asymmetry patterning. Some animals (17%) tend to develop pronephric cysts. At the 7-somite stage, cilia number and length are reduced in the Kupffer's vesicle. At 60 hpf, cilia motility is markedly impaired in the pronephric duct.
messages: cilium axoneme

7955:si:ch211-122f10.4
gene id: 7955:si:ch211-122f10.4
uniprot id: F1QYP6
names: Similarity
messages: Belongs to the peptidase S10 family.

7955:ebf1b
gene id: 7955:ebf1b
uniprot id: A0A286YBI5
uniprot id: A0A8M2B8M6
uniprot id: A0A8M9P423
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

7955:idi1
gene id: 7955:idi1
uniprot id: F1QVG2
uniprot id: Q4V8U6
names: Function
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

7955:cmtm8a
gene id: 7955:cmtm8a
uniprot id: A0A8M2B672
names: Subcellular Location Annotation
messages: Membrane

7955:trub1
gene id: 7955:trub1
uniprot id: B3DHG0
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

7955:spout1
gene id: 7955:spout1
uniprot id: Q66ID3
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.

7955:rarga
gene id: 7955:rarga
uniprot id: Q91392
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: By retinoic acid, in embryonic anterior brain and eye.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Expressed zygotically, with greatest expression at 24 hours post-fertilization (hpf). At 9 hpf, shows ubiquitous expression in the epiblast. At 10 hpf, expressed in anterior and posterior regions; not expressed in the presumptive hindbrain, and anterior expression is limited to mesoderm adjacent to the head. Between 11-15 hpf restricted expression in the cranial mesoderm and tailbud. At 12 hpf, expressed in anterior lateral mesenchyme, with strongest expression lateral to the future hindbrain, and in tailbud. At 24 hpf, also expressed in the hindbrain, neural crest cells and tail; not detected in spinal cord. At 48 hpf, hindbrain expression increases with an anterior border at rhombomere 3 and a posterior border at the spinal cord/hindbrain junction; expressed in stripes one rhombomere wide in dorsal hindbrain. At 48 hpf, also expressed in pharangeal arches 1-7, anterior neurocranium, cells separating the eyes and forebrain, pectoral fin buds and tailbud. Embryonic zygotic expression overlaps that of raraa and rarab, but there is stronger expression in the posterior hindbrain beginning in late somitogenesis, and in neural crest cells in the pharangeal arches. In the adult, strongly expressed in the ovary, brain and muscle, and weakly expressed in the liver and digestive tract.
messages: Heterodimer; with an rxr molecule. Binds DNA preferentially as a rar/rxr heterodimer.
messages: Nucleus
messages: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development and for the development of pharyngeal arches.

7955:ddost
gene id: 7955:ddost
uniprot id: A0A0R4I9F5
uniprot id: Q6NYS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDOST 48 kDa subunit family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (By similarity). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (By similarity).
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).

7955:LOC108190403
gene id: 7955:LOC108190403
uniprot id: A0A8M9QBI7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:cluap1
gene id: 7955:cluap1
uniprot id: A0A8M9P5T3
uniprot id: A0A8M9PTX5
uniprot id: A0A8M9PXC0
uniprot id: Q7ZVC2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLUAP1 family.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Expressed maternally and ubiquitously throughout the embryo across different developmental stages from early 8-cell stage to 24 hpf.
messages: Mutant animals develop ventrally curved bodies visible at the end of 1 dpf, followed by bilateral kidney cysts in the glomerular-tubular region detectable at 2 dpf. Cilia in the anterior pronephric ducts are already visibly defective at 1 dpf and by 5 dpf, cilia are completely absent from these ducts. On the other hand, cilia from the posterior pronephric ducts remain unaffected. Cilia biogenesis is also defective in the retina, with the outer segments of photoreceptor cells having modified cilia. No visible cilia in the lateral line organ. Pericardial edema is also observed at 5 dpf (PubMed:22102889). Morpholino knockdown in embryos results in laterality defects, a significant reduction or loss of Kupffer's vesicle cilia, and reduction or loss of ptc1 and myod expression (PubMed:19464178). A subset of embryos display shortened body axes and partial or full cyclopia while another subset have severe gastrulation defects (PubMed:19464178).
messages: Nucleus
messages: Required for cilia biogenesis and maintenance in the kidney, the lateral line organ and eye. Appears to function within the multiple intraflagellar transport complex B (IFT-B).
messages: cilium

7955:zgc:175248
gene id: 7955:zgc:175248
uniprot id: A9JTH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Membrane

7955:oat
gene id: 7955:oat
uniprot id: F8W5L3
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

7955:pign
gene id: 7955:pign
uniprot id: A0A8M3B6M9
uniprot id: E7EXW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Membrane

7955:kcnv2a
gene id: 7955:kcnv2a
uniprot id: F1Q6N3
names: Subcellular Location Annotation
messages: Membrane

7955:gpr157
gene id: 7955:gpr157
uniprot id: Q498W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 5 family.
messages: Membrane

7955:si:dkey-22n8.3
gene id: 7955:si:dkey-22n8.3
uniprot id: A0A8M1RES1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion

7955:LOC101884879
gene id: 7955:LOC101884879
uniprot id: A0A8M2BBW9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:ephb2a
gene id: 7955:ephb2a
uniprot id: A0A8M9PL45
uniprot id: A0A8M9PWU2
names: Subcellular Location Annotation
messages: Membrane

7955:si:ch73-382f3.1
gene id: 7955:si:ch73-382f3.1
uniprot id: A0A8M1NZL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: nucleoplasm

7955:LOC103911715
gene id: 7955:LOC103911715
uniprot id: A0A8M3AWI4
names: Similarity
messages: Belongs to the HARBI1 family.

7955:si:dkey-78a14.4
gene id: 7955:si:dkey-78a14.4
uniprot id: E7FAM7
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

7955:gna15.1
gene id: 7955:gna15.1
uniprot id: A0A8M2BHS4
uniprot id: F1QJL5
uniprot id: Q6DEH5
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

7955:gpx7
gene id: 7955:gpx7
uniprot id: Q502E1
names: Similarity
messages: Belongs to the glutathione peroxidase family.

7955:abcg2b
gene id: 7955:abcg2b
uniprot id: Q2Q446
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

7955:copz1
gene id: 7955:copz1
uniprot id: Q9IB48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

7955:xcr1b.1
gene id: 7955:xcr1b.1
uniprot id: A0A8M9PRS6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:nagk
gene id: 7955:nagk
uniprot id: A0A0R4IUJ5
uniprot id: A7MBU8
names: Similarity
messages: Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

7955:desmb
gene id: 7955:desmb
uniprot id: A0A8M9QFJ6
uniprot id: Q05AI8
names: Similarity
messages: Belongs to the intermediate filament family.

7955:si:ch211-223a10.1
gene id: 7955:si:ch211-223a10.1
uniprot id: F1QHU6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

7955:foxj2
gene id: 7955:foxj2
uniprot id: E7FA97
names: Subcellular Location Annotation
messages: Nucleus

7955:prph2l
gene id: 7955:prph2l
uniprot id: A9JRF5
names: Subcellular Location Annotation
messages: Membrane

7955:nmur1a
gene id: 7955:nmur1a
uniprot id: A0A8M9PE67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

7955:dspa
gene id: 7955:dspa
uniprot id: A0A8M2BID5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plakin or cytolinker family.
messages: Cell membrane
messages: Expressed in the periderm and enveloping layer between 6 hours post-fertilization (hpf) to 16 hpf. Expressed in the epidermis, otic vesicle, gut, neural tube, pharynx, pectoral fin, and olfactory organ from 1 to 5 dpf. Expressed in the lens and cardiac region at 6 hpf to 5 dpf.
messages: Involved in the organization of desmosome cell-cell junctions (PubMed:29522173). Of particular importance in cell adhesion in the skin and during cardiac development (PubMed:29522173). May also play a role in the regulation of Wnt, TGF-beta and Hippo signaling pathways (PubMed:29522173).
messages: Morpholino knockdowns show no general morphological differences however do show a slight developmental delay (PubMed:29522173). Abnormal skin surface, reduced numbers of desmosome cell-cell junctions and disorganization of remaining desmosome at 2 dpf (PubMed:29522173). Cardiac regions show reduced desmosome numbers, detached cells and pericardial effusion. Reduced resting heart rate (PubMed:29522173). A cardiac reduction in Wnt and TGF-beta signaling is also evident, with an increase in Hippo signaling (PubMed:29522173).
messages: desmosome

7955:plxna1a
gene id: 7955:plxna1a
uniprot id: A0A8M1RJK2
uniprot id: A0A8M6Z3W4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:pacsin2
gene id: 7955:pacsin2
uniprot id: A0A0R4IHF0
uniprot id: F1QC13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PACSIN family.
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: caveola
messages: ruffle membrane

7955:fuca1.1
gene id: 7955:fuca1.1
uniprot id: Q7ZW80
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

7955:dlgap2a
gene id: 7955:dlgap2a
uniprot id: A0A8M9PP92
uniprot id: A0A8M9PPH8
names: Similarity
messages: Belongs to the SAPAP family.

7955:lhfpl4b
gene id: 7955:lhfpl4b
uniprot id: A0A8M3AUX7
names: Subcellular Location Annotation
messages: Membrane

7955:LOC100333521
gene id: 7955:LOC100333521
uniprot id: A0A8M1RDC6
uniprot id: A0A8M2BI06
names: Similarity
messages: Belongs to the peptidase C1 family.

7955:ddb1
gene id: 7955:ddb1
uniprot id: Q6PGT6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDB1 family.
messages: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock.
messages: Component of the UV-DDB complex.
messages: Nucleus
messages: The core of the protein consists of three WD40 beta-propeller domains.

7955:ldb2b
gene id: 7955:ldb2b
uniprot id: O73714
names: Similarity
messages: Belongs to the LDB family.

7955:tpd52l2a
gene id: 7955:tpd52l2a
uniprot id: A0A2R8QN88
uniprot id: A0A8M2BEH5
uniprot id: A0A8M3B1Z0
uniprot id: A0A8M9Q9I8
uniprot id: E9QF87
uniprot id: E9QG97
uniprot id: Q803K5
names: Similarity
messages: Belongs to the TPD52 family.

7955:si:ch211-218m3.13
gene id: 7955:si:ch211-218m3.13
uniprot id: E7FBP1
names: Subcellular Location Annotation
messages: Membrane

7955:lsm6
gene id: 7955:lsm6
uniprot id: A0A8M2B6V1
uniprot id: Q6IMW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

7955:dpep2
gene id: 7955:dpep2
uniprot id: E7FBC7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Homodimer; disulfide-linked.
messages: Membrane

7955:clcn4
gene id: 7955:clcn4
uniprot id: Q08BG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

7955:si:ch211-223p8.8
gene id: 7955:si:ch211-223p8.8
uniprot id: B7ZD10
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of AMPK and MAPK1/2 signaling pathways.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

7955:slc2a11l
gene id: 7955:slc2a11l
uniprot id: A1A5Y3
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

7955:ifnphi2
gene id: 7955:ifnphi2
uniprot id: A8E6E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

7955:LOC110437758
gene id: 7955:LOC110437758
uniprot id: A0A8M9P2X4
uniprot id: A0A8M9PPV8
names: Similarity
messages: Belongs to the nesprin family.

7955:rheb
gene id: 7955:rheb
uniprot id: Q6PC18
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

7955:taf6l
gene id: 7955:taf6l
uniprot id: A0A8M6Z002
uniprot id: A0A8M9QH20
uniprot id: E7FEV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

7955:tpi1a
gene id: 7955:tpi1a
uniprot id: Q1MTI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
messages: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.

7955:etnppl
gene id: 7955:etnppl
uniprot id: Q7SY54
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde.
messages: Does not seem to possess aminotransferase activity.
messages: Homotetramer.
messages: Mitochondrion

7955:tspan4a
gene id: 7955:tspan4a
uniprot id: A0A8M3AS88
uniprot id: A0A8M3AV73
uniprot id: A0A8M3B373
uniprot id: A0A8M9PM20
uniprot id: A0A8M9PQ52
uniprot id: Q6DHQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7955:usp7
gene id: 7955:usp7
uniprot id: A0A8M3AQW7
uniprot id: A0A8M3B0Y8
uniprot id: A0A8M3B8A7
uniprot id: A0A8M9Q474
uniprot id: F1QUS9
uniprot id: I3ISS5
names: Similarity
messages: Belongs to the peptidase C19 family.

7955:ndufab1b
gene id: 7955:ndufab1b
uniprot id: F1QCE9
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

7955:or122-2
gene id: 7955:or122-2
uniprot id: Q2PRI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:mecp2
gene id: 7955:mecp2
uniprot id: A8WIP2
uniprot id: Q7T2T7
names: Function
names: Subcellular Location Annotation
messages: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
messages: Nucleus

7955:wnt11r
gene id: 7955:wnt11r
uniprot id: Q9I9I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

7955:LOC110438149
gene id: 7955:LOC110438149
uniprot id: A0A8M9PBH0
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

7955:hoxc11b
gene id: 7955:hoxc11b
uniprot id: A0A0R4IDM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

7955:si:ch211-214p13.9
gene id: 7955:si:ch211-214p13.9
uniprot id: A0A8M1RSR2
uniprot id: A0A8M2BES3
names: Similarity
messages: Belongs to the CD200R family.

7955:cenpv
gene id: 7955:cenpv
uniprot id: A0A8M9QES7
names: Similarity
messages: Belongs to the Gfa family.

7955:LOC100150038
gene id: 7955:LOC100150038
uniprot id: A3KPR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:LOC103909721
gene id: 7955:LOC103909721
uniprot id: A0A8M3AVS3
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:mars
gene id: 7955:mars
uniprot id: Q6TEM5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

7955:si:ch211-63b16.4
gene id: 7955:si:ch211-63b16.4
uniprot id: A0A8M3AU98
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:npm2b
gene id: 7955:npm2b
uniprot id: B2CQD3
names: Similarity
messages: Belongs to the nucleoplasmin family.

7955:ttc36
gene id: 7955:ttc36
uniprot id: A8E7I5
names: Similarity
messages: Belongs to the TTC36 family.

7955:sema4bb
gene id: 7955:sema4bb
uniprot id: F1QU86
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:zdhhc8a
gene id: 7955:zdhhc8a
uniprot id: A0A8N7UUM3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

7955:tctex1d2
gene id: 7955:tctex1d2
uniprot id: F1QMY1
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system (By similarity). Required for proper retrograde ciliary transport (PubMed:26044572).
messages: Belongs to the dynein light chain Tctex-type family.
messages: Dynein axonemal particle
messages: Morpholino knockdown of the protein produces a dose dependent typical ciliopathy phenotype, with ventrally curved body axis, hydrocephalus, abnormal otoliths and small eyes. The few embryos surviving to 4 days post fertilization display severe generalized edema, pronephric cysts, and defects of the craniofacial cartilage.

7955:ccni2
gene id: 7955:ccni2
uniprot id: E7EXT9
names: Similarity
messages: Belongs to the cyclin family.

7955:tln1
gene id: 7955:tln1
uniprot id: A0A8M2B1K5
uniprot id: A0A8M2B1Z7
uniprot id: A0A8M9PTJ3
uniprot id: A0A8M9Q646
uniprot id: Q5U7N6
names: Subcellular Location Annotation
messages: cytoskeleton

7955:cyp1c2
gene id: 7955:cyp1c2
uniprot id: B0JZN5
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:ugt1b7
gene id: 7955:ugt1b7
uniprot id: D3XD69
names: Similarity
messages: Belongs to the UDP-glycosyltransferase family.

7955:tmem264
gene id: 7955:tmem264
uniprot id: Q1L877
names: Similarity
messages: Belongs to the TMEM121 family.

7955:ndel1b
gene id: 7955:ndel1b
uniprot id: B2GRS6
uniprot id: Q803Q2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudE family.
messages: Phosphorylated in mitosis.
messages: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end (By similarity).
messages: centrosome
messages: cytoskeleton
messages: spindle

7955:zgc:165520
gene id: 7955:zgc:165520
uniprot id: B8A651
names: Similarity
messages: Belongs to the syntaxin family.

7955:ddx52
gene id: 7955:ddx52
uniprot id: A0A0R4IJV5
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

7955:atp1a1a.1
gene id: 7955:atp1a1a.1
uniprot id: Q9DGL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane

7955:cenpn
gene id: 7955:cenpn
uniprot id: Q6DHP4
names: Similarity
messages: Belongs to the CENP-N/CHL4 family.

7955:si:dkey-47k20.7
gene id: 7955:si:dkey-47k20.7
uniprot id: A0A8M9PFX0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:nif3l1
gene id: 7955:nif3l1
uniprot id: Q4KMJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Cytoplasm
messages: Homodimer. Interacts with COPS2. Interacts with THOC7.
messages: May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.
messages: Nucleus

7955:LOC100329772
gene id: 7955:LOC100329772
uniprot id: A0A8M9PL68
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:htr7
gene id: 7955:htr7
uniprot id: A0A0G2L2K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:ypel1
gene id: 7955:ypel1
uniprot id: Q6AXK6
names: Similarity
messages: Belongs to the yippee family.

7955:exoc8
gene id: 7955:exoc8
uniprot id: A4IG64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EXO84 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: growth cone
messages: perinuclear region

7955:plp1a
gene id: 7955:plp1a
uniprot id: Q8UUT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

7955:fgf5
gene id: 7955:fgf5
uniprot id: Q5TLE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Secreted

7955:mrpl24
gene id: 7955:mrpl24
uniprot id: Q6DH02
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

7955:si:dkey-71l1.1
gene id: 7955:si:dkey-71l1.1
uniprot id: A9JSV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

7955:osgepl1
gene id: 7955:osgepl1
uniprot id: Q32LQ3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Mitochondrion
messages: Monomer.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

7955:slc13a1
gene id: 7955:slc13a1
uniprot id: Q6PE27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

7955:LOC100148950
gene id: 7955:LOC100148950
uniprot id: A0A8M1QHL6
uniprot id: A0A8M9P935
names: Similarity
messages: Belongs to the formin homology family. Cappuccino subfamily.

7955:ces2
gene id: 7955:ces2
uniprot id: A0A8M9PFI2
uniprot id: Q08BF1
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

7955:LOC797658
gene id: 7955:LOC797658
uniprot id: A0A8M3AUT3
names: Similarity
messages: Belongs to the RASGRP family.

7955:dync1li1
gene id: 7955:dync1li1
uniprot id: A0A0R4ICI6
uniprot id: A0A8M3ASH7
uniprot id: A0A8M3AVG4
uniprot id: Q1LUM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

7955:supt4h1
gene id: 7955:supt4h1
uniprot id: Q6DGQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT4 family.
messages: Interacts with SUPT5H to form the DSIF complex. DSIF interacts with RNA polymerase II and with the positive transcription elongation factor b complex (P-TEFb complex), which is composed of CDK9 and cyclin-T (By similarity).
messages: May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. Probably enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. Also acts to stimulate transcriptional elongation at low nucleotide concentrations. Regulation of transcriptional elongation by this protein is required for the expression of genes which control neuronal development (By similarity).
messages: Nucleus

7955:fbxw11a
gene id: 7955:fbxw11a
uniprot id: A0A2R8QFQ6
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: At 4 days post fertilization (dpf), it is expressed at low levels in the retina and brain, and at higher levels in the jaw mesenchyme.
messages: Cytoplasm
messages: Knockdown of both fbxw11a and fbxw11b results in abnormally developed pectoral fins and heart edema by day 3 post-fertilization (3 dpf). At 5 dpf, knocked-down embryos show periocular edema, small and misshapen eyes, and abnormal development of the jaw.
messages: Nucleus
messages: Self-associates. Component of the SCF(FBXW11) complex.
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Probably recognizes and binds to phosphorylated target proteins: the interaction with substrates requires the phosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S (By similarity). SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling regulation (By similarity). Participates in Wnt signaling regulation, and plays a role in eye and jaw development (PubMed:31402090). SCF(FBXW11) plays a key role in NF-kappa-B activation by mediating ubiquitination of phosphorylated NFKBIA, leading to its degradation by the proteasome, thereby allowing the associated NF-kappa-B complex to translocate into the nucleus and to activate transcription (By similarity).
messages: The N-terminal D domain mediates homodimerization.

7955:rhbdd2
gene id: 7955:rhbdd2
uniprot id: E9QI41
names: Subcellular Location Annotation
messages: Membrane

7955:ntn1b
gene id: 7955:ntn1b
uniprot id: F1QUK5
uniprot id: O42203
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:zgc:109949
gene id: 7955:zgc:109949
uniprot id: A0A0R4IY94
uniprot id: A0A8M1N650
uniprot id: Q504D0
names: Similarity
messages: Belongs to the folate receptor family.

7955:v2rx1
gene id: 7955:v2rx1
uniprot id: Q1LV86
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:ethe1
gene id: 7955:ethe1
uniprot id: Q6NWI8
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

7955:txndc5
gene id: 7955:txndc5
uniprot id: F1R184
uniprot id: Q6PFL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

7955:fam131ba
gene id: 7955:fam131ba
uniprot id: A0A8M3AVE0
uniprot id: A0A8M3B3E2
uniprot id: A0A8M6YUQ2
uniprot id: A0A8M9P2A5
uniprot id: A0A8M9PBE9
uniprot id: F1QMB3
names: Similarity
messages: Belongs to the FAM131 family.

7955:cfap157
gene id: 7955:cfap157
uniprot id: A2BDR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP157 family.
messages: Specifically required during spermatogenesis for flagellum morphogenesis and sperm motility.
messages: cilium basal body

7955:nsmfb
gene id: 7955:nsmfb
uniprot id: B8PYG1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSMF family.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in the olfactory bulb, telencephalon, hypothalamus, midbrain tegmentum, retina, hindbrain and the spinal cord. Expressed in GnRH3 neurons within the olfactory epithelium and terminal nerve.
messages: Membrane
messages: Nucleus
messages: Nucleus envelope
messages: Nucleus matrix
messages: Nucleus membrane
messages: Postsynaptic density
messages: Stimulates outgrowth of olfactory axons and migration of hypophysiotropic gonadotropin-releasing hormone 3 (GnRH3) neurons. May couple NMDA-sensitive glutamate receptor signaling to the nucleus and trigger long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes.
messages: Synapse
messages: cell cortex
messages: cytoskeleton
messages: dendrite
messages: synaptosome

7955:xrcc5
gene id: 7955:xrcc5
uniprot id: A0A0R4IB13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus
messages: Single-stranded DNA-dependent ATP-dependent helicase.

7955:myct1a
gene id: 7955:myct1a
uniprot id: Q5SNQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYCT1 family.
messages: Nucleus

7955:kcnh8
gene id: 7955:kcnh8
uniprot id: A0A8M6Z362
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

7955:ap1b1
gene id: 7955:ap1b1
uniprot id: A0A8M2BCC8
uniprot id: A0A8M2BCE3
uniprot id: A0A8M2BCH0
uniprot id: A0A8M3AS47
uniprot id: A0A8M3AZG4
uniprot id: A0A8M3B9I1
uniprot id: A0A8M9PKD8
uniprot id: A5PMS9
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

7955:impg1b
gene id: 7955:impg1b
uniprot id: A0A8M3AJ68
uniprot id: A0A8M3B2K4
uniprot id: A0A8M9PPL9
uniprot id: A0A8N7T6R1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: interphotoreceptor matrix

7955:LOC103908848
gene id: 7955:LOC103908848
uniprot id: A0A8M3ASW1
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:sgut1
gene id: 7955:sgut1
uniprot id: Q5U3E4
names: Similarity
messages: Belongs to the SGT1 family.

7955:pfkma
gene id: 7955:pfkma
uniprot id: Q66HV8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:cog7
gene id: 7955:cog7
uniprot id: Q08BK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG7 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:si:dkey-208k22.6
gene id: 7955:si:dkey-208k22.6
uniprot id: B0UXT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

7955:rnaset2l
gene id: 7955:rnaset2l
uniprot id: A0A8M9NYL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase T2 family.
messages: Lysosome lumen

7955:wisp2
gene id: 7955:wisp2
uniprot id: D0E2V9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:ppp1r7
gene id: 7955:ppp1r7
uniprot id: Q32PL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDS22 family.
messages: Nucleus
messages: Regulatory subunit of protein phosphatase 1.

7955:bgna
gene id: 7955:bgna
uniprot id: Q6GMI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: May be involved in collagen fiber assembly.
messages: extracellular matrix

7955:stk11ip
gene id: 7955:stk11ip
uniprot id: A0A0R4IIP9
uniprot id: A0A8M9QFK4
uniprot id: F1Q5L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STK11IP family.
messages: Cytoplasm

7955:wnt9a
gene id: 7955:wnt9a
uniprot id: B6V3E1
uniprot id: Q0P406
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

7955:clcc1
gene id: 7955:clcc1
uniprot id: A0A2R8Q3S9
uniprot id: A0A8M9PSH2
uniprot id: H9GYN2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the chloride channel MCLC family.
messages: Endoplasmic reticulum membrane
messages: Expressed in the hindbrain, swim bladder and the eye at 1 day post fertilization (dpf) with increased expression at 3 dpf (PubMed:30157172). At 3 dpf, most prominent expression in the retina, with strong expression in the ganglion cell layer, outer nuclear layer and the retinal pigmented epithelium (PubMed:30157172).
messages: Golgi apparatus membrane
messages: Knockout leads to lethality at 11 dpf, with knockout larvae exhibiting abnormalities in various retinal layers including the inner plexiform layer, the outer nuclear layer and the rod photoreceptor layer and decreased function of the photoreceptor cone cells (PubMed:30157172). Morpholino knockdown results in reduced eye size with proportionately decreased lens size, thinner inner plexiform layer and outer nuclear layer after 36 hours post fertilization (hpf) (PubMed:30157172). No change in the inner nuclear layer, but increased apparent thickness of the ganglion cell layer (PubMed:30157172). Reduced number of rod cells, with existing rod cells exhibiting an abnormal morphology or pyknotic appearance, decreased opsin levels and disrupted photoreceptor cell bodies (PubMed:30157172).
messages: Membrane
messages: Nucleus membrane
messages: Seems to act as a chloride ion channel (By similarity). Plays a role in retina development (PubMed:30157172).

7955:bod1
gene id: 7955:bod1
uniprot id: Q08CT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BOD1 family.
messages: centrosome
messages: kinetochore

7955:LOC101882770
gene id: 7955:LOC101882770
uniprot id: A0A8M2B5F1
names: Function
names: Subunit
messages: Interacts with ITGAL, ITGAM and ITGB2.
messages: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

7955:si:dkeyp-111e5.4
gene id: 7955:si:dkeyp-111e5.4
uniprot id: E7F5I7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:si:dkey-5g14.1
gene id: 7955:si:dkey-5g14.1
uniprot id: A0A8M3AWS9
names: Subcellular Location Annotation
messages: Membrane

7955:nmt1b
gene id: 7955:nmt1b
uniprot id: A0A8M2B307
uniprot id: A0A8M9QMJ8
uniprot id: B8JIQ9
names: Function
names: Similarity
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.

7955:LOC110440162
gene id: 7955:LOC110440162
uniprot id: A0A8M9QN66
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

7955:desi1b
gene id: 7955:desi1b
uniprot id: Q7ZTH7
names: Similarity
messages: Belongs to the DeSI family.

7955:allc
gene id: 7955:allc
uniprot id: B2GQF5
uniprot id: Q6DGA6
names: Function
names: Similarity
messages: Belongs to the allantoicase family.
messages: Utilization of purines as secondary nitrogen sources, when primary sources are limiting.

7955:stk38b
gene id: 7955:stk38b
uniprot id: A0A8M6YV57
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:nop16
gene id: 7955:nop16
uniprot id: Q6DGI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP16 family.
messages: nucleolus

7955:pik3c2g
gene id: 7955:pik3c2g
uniprot id: A0A8M6Z287
uniprot id: A0A8M9PMY2
uniprot id: A0A8M9PR53
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

7955:si:dkey-23a13.17
gene id: 7955:si:dkey-23a13.17
uniprot id: A0A140LH24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

7955:metap1d
gene id: 7955:metap1d
uniprot id: Q4VBS4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Mitochondrion
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

7955:histh1l
gene id: 7955:histh1l
uniprot id: Q568D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

7955:zgc:162183
gene id: 7955:zgc:162183
uniprot id: A0A8M6Z1F8
uniprot id: A4QNV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

7955:ptdss1b
gene id: 7955:ptdss1b
uniprot id: A0A8N7T7D0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:mtmr1b
gene id: 7955:mtmr1b
uniprot id: A0A0R4IMW4
uniprot id: Q58EE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

7955:lrrc39
gene id: 7955:lrrc39
uniprot id: F1R6I3
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress (By similarity). May regulate expression of other M-band proteins via an SRF-dependent pathway (By similarity). Important for normal contractile function in heart (PubMed:20847312).
messages: M line
messages: Morpholino knockdown of the protein results in severe contractile dysfunction of the heart, leading to pericaridal edema and blood congestion. Heart development and gross cardiac morphology appear to be normal. Cardiomyocytes show some ultrastructural abnormalities including narrowing of the M-band and a poorly defined A-band/M-band transition.

7955:zgc:194330
gene id: 7955:zgc:194330
uniprot id: B3DHV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:zgc:172131
gene id: 7955:zgc:172131
uniprot id: A0A8M9QBT3
uniprot id: A0A8M9QKI1
uniprot id: A8WG18
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:nudt5
gene id: 7955:nudt5
uniprot id: Q6IQ66
names: Similarity
messages: Belongs to the Nudix hydrolase family.

7955:tmem63c
gene id: 7955:tmem63c
uniprot id: B0R175
uniprot id: X1WEM4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an osmosensitive calcium-permeable cation channel (By similarity). Required for the functional integrity of the kidney glomerular filtration barrier (PubMed:30900988).
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Cell membrane
messages: Membrane
messages: Morpholino knockdown induced a glomerular filtration barrier defect.

7955:acad8
gene id: 7955:acad8
uniprot id: Q7ZYY0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

7955:cited4a
gene id: 7955:cited4a
uniprot id: Q08CF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CITED family.
messages: Nucleus

7955:si:dkeyp-50d11.2
gene id: 7955:si:dkeyp-50d11.2
uniprot id: E9QFN0
names: Similarity
messages: Belongs to the peptidase C2 family.

7955:tomm40
gene id: 7955:tomm40
uniprot id: A0A8M6Z1R1
uniprot id: Q7T314
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

7955:yrk
gene id: 7955:yrk
uniprot id: Q8AWF1
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

7955:olfcw1
gene id: 7955:olfcw1
uniprot id: Q501X9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:zgc:112052
gene id: 7955:zgc:112052
uniprot id: A8KC47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the C19orf12 family.
messages: Mitochondrion membrane

7955:prdm10
gene id: 7955:prdm10
uniprot id: A0A0R4IF41
uniprot id: A0A8M3AV43
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

7955:malrd1
gene id: 7955:malrd1
uniprot id: A0A8M9Q147
uniprot id: E7F1Z9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:ddx43
gene id: 7955:ddx43
uniprot id: B8A609
names: Similarity
messages: Belongs to the DEAD box helicase family.

7955:sfxn5a
gene id: 7955:sfxn5a
uniprot id: A0A8M1P320
uniprot id: A0A8M3B7V4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

7955:slc16a6b
gene id: 7955:slc16a6b
uniprot id: A0A8M9PGA4
uniprot id: I3ITI5
names: Subcellular Location Annotation
messages: Membrane

7955:hsd17b4
gene id: 7955:hsd17b4
uniprot id: A0A8M9PQQ8
uniprot id: Q8AYH1
names: Subcellular Location Annotation
messages: Peroxisome

7955:gpc5a
gene id: 7955:gpc5a
uniprot id: V5NES1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

7955:med12
gene id: 7955:med12
uniprot id: A0A0R4IBL3
uniprot id: A0A8M3AHU7
uniprot id: A0A8M3B095
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 12 family.
messages: Nucleus

7955:stat2
gene id: 7955:stat2
uniprot id: A0A8M1NZ93
uniprot id: A0A8M3ATI0
uniprot id: A0A8M6Z7C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

7955:LOC101882461
gene id: 7955:LOC101882461
uniprot id: A0A8M6YTR0
uniprot id: A0A8M9PDY2
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

7955:nucb2b
gene id: 7955:nucb2b
uniprot id: Q7ZUS2
names: Similarity
messages: Belongs to the nucleobindin family.

7955:st6galnac6
gene id: 7955:st6galnac6
uniprot id: A0A8M6YV93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

7955:slc39a9
gene id: 7955:slc39a9
uniprot id: A9JT08
uniprot id: Q5BL29
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Cell membrane
messages: Expressed in vitellogenic oocytes, ovulated eggs, and in ovarian follicle cells (PubMed:32973303). Highly expressed in early-mid vitellogenic oocytes and significantly lower in full grown oocytes and ovulated eggs (PubMed:32973303).
messages: Has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through G protein activation and are required for the androgen-dependent apoptotic response. Upon androgen binding, mediates apoptosis by directly activating a stimulatory G protein that leads to increased cAMP levels and MAP kinase activity and which is accompanied by increased intracellular free zinc levels (By similarity). May play a role in the proper zinc modulation during egg activation (PubMed:32973303).
messages: Homozygous Knockout females fish for SLC39A9 show significant reductions in fecundity, embryo viability, and growth of their offspring. Furthermore, a high proportion of eggs fail to undergo normal chorion elevation during activation.
messages: Membrane
messages: Mitochondrion
messages: Nucleus
messages: Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.
messages: perinuclear region
messages: trans-Golgi network membrane

7955:fam102bb
gene id: 7955:fam102bb
uniprot id: A0A8M2B7L8
uniprot id: A0A8M3AWB0
uniprot id: Q5RH77
names: Similarity
messages: Belongs to the EEIG family.

7955:cdk1
gene id: 7955:cdk1
uniprot id: Q7T3L7
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:smg1
gene id: 7955:smg1
uniprot id: A0A8M3AQW2
uniprot id: A0A8M3B0Y6
uniprot id: C5J7W8
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autophosphorylated.
messages: Belongs to the PI3/PI4-kinase family.
messages: Cytoplasm
messages: Expressed during early cleavage, gastrulation and at 1 day post-fertilization.
messages: Morpholino knockdown results in reduced slc24a5 expression in wild-type embryos however expression is still detectable in the body and retinal pigment epithelium (PubMed:19414594). In 50% of the embryos expression of slc24a5 is restricted to the retina (PubMed:19414594).
messages: Nucleus
messages: Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1.

7955:antxr1a
gene id: 7955:antxr1a
uniprot id: A0A8M1PU60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

7955:bmp6
gene id: 7955:bmp6
uniprot id: A0A8M9PFZ4
uniprot id: Q5CZV5
names: Similarity
messages: Belongs to the TGF-beta family.

7955:si:ch211-160o17.2
gene id: 7955:si:ch211-160o17.2
uniprot id: A0A8N7TAF6
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

7955:arrb1
gene id: 7955:arrb1
uniprot id: C3PTE8
uniprot id: Q5XJ55
names: Similarity
messages: Belongs to the arrestin family.

7955:dapk2b
gene id: 7955:dapk2b
uniprot id: A0A0R4IK49
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:nek6
gene id: 7955:nek6
uniprot id: A0A8M1RFQ9
uniprot id: A0A8M9PUE6
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:si:dkey-288i20.2
gene id: 7955:si:dkey-288i20.2
uniprot id: A0A2R8Q8U4
uniprot id: E7FBD4
names: Similarity
messages: Belongs to the zygin family.

7955:LOC100151049
gene id: 7955:LOC100151049
uniprot id: A0A0G2L9C2
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

7955:fgfbp2a
gene id: 7955:fgfbp2a
uniprot id: F1R8L1
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

7955:pcdh2ab10
gene id: 7955:pcdh2ab10
uniprot id: Q60I67
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

7955:htr1aa
gene id: 7955:htr1aa
uniprot id: B0S6X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:tmem56b
gene id: 7955:tmem56b
uniprot id: B2GQ47
uniprot id: Q5XIY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TLCD4 family.
messages: Membrane

7955:nr5a2
gene id: 7955:nr5a2
uniprot id: A0A8M3AXL9
uniprot id: Q90YL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

7955:gorasp1a
gene id: 7955:gorasp1a
uniprot id: A0A8M2BIG8
uniprot id: Q5U3V8
names: Similarity
messages: Belongs to the GORASP family.

7955:pfkla
gene id: 7955:pfkla
uniprot id: E7F9M6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:prkar2ab
gene id: 7955:prkar2ab
uniprot id: Q6NW93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

7955:cep44
gene id: 7955:cep44
uniprot id: A0A8M9PJ84
uniprot id: A0A8M9PWN9
uniprot id: F6NJX7
names: Subcellular Location Annotation
messages: Midbody
messages: centriole
messages: spindle pole

7955:lyz
gene id: 7955:lyz
uniprot id: Q90YS5
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

7955:dock5
gene id: 7955:dock5
uniprot id: A8E1V7
names: Similarity
messages: Belongs to the DOCK family.

7955:pik3c2a
gene id: 7955:pik3c2a
uniprot id: A0A8M9PQU0
uniprot id: F6NMW9
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

7955:wnt6b
gene id: 7955:wnt6b
uniprot id: F1R205
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

7955:lrrfip2
gene id: 7955:lrrfip2
uniprot id: A0A0R4IMS4
uniprot id: A0A8M2BGT5
uniprot id: A0A8M2BGV2
uniprot id: A0A8M2BGW9
uniprot id: A0A8M2BHE2
uniprot id: A0A8M6Z279
uniprot id: A0A8M6Z935
uniprot id: A0A8M9PXP5
uniprot id: A0A8M9PXQ2
uniprot id: A0A8M9Q9K7
uniprot id: A0A8M9QF96
uniprot id: A0A8M9QJK5
uniprot id: A0A8M9QNB1
uniprot id: Q6PGV0
names: Similarity
messages: Belongs to the LRRFIP family.

7955:hgh1
gene id: 7955:hgh1
uniprot id: Q6DGR4
names: Similarity
messages: Belongs to the HGH1 family.

7955:mchr1a
gene id: 7955:mchr1a
uniprot id: A0A8M1PV65
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with NCDN.
messages: Membrane

7955:neto1l
gene id: 7955:neto1l
uniprot id: A0A8M9PGC0
uniprot id: A0A8M9PM78
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC101886064
gene id: 7955:LOC101886064
uniprot id: A0A8M3AIM4
names: Similarity
messages: Belongs to the helicase family.

7955:ermp1
gene id: 7955:ermp1
uniprot id: A0A8M2BL61
names: Subcellular Location Annotation
messages: Membrane

7955:cx32.3
gene id: 7955:cx32.3
uniprot id: Q7T2D7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

7955:stt3a
gene id: 7955:stt3a
uniprot id: Q7ZUY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

7955:unk
gene id: 7955:unk
uniprot id: F1Q639
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unkempt family.
messages: Cytoplasm

7955:dnmt3ab
gene id: 7955:dnmt3ab
uniprot id: A0A8M3B2J9
uniprot id: A0A8M9P050
uniprot id: A0A8M9P8W7
uniprot id: B3DGZ8
uniprot id: F1R1K5
uniprot id: Q588C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Nucleus

7955:LOC100333270
gene id: 7955:LOC100333270
uniprot id: E7F9I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:kcnk18
gene id: 7955:kcnk18
uniprot id: D7NVC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

7955:olfcg4
gene id: 7955:olfcg4
uniprot id: A0A0R4ITC7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:ezrb
gene id: 7955:ezrb
uniprot id: Q5TZG5
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

7955:abi2b
gene id: 7955:abi2b
uniprot id: A0A8M2BD18
uniprot id: A0A8M2BD24
uniprot id: A0A8M2BD58
uniprot id: A0A8M3AT64
uniprot id: A0A8M9PM97
uniprot id: A0A8M9PZX3
uniprot id: A0A8M9Q683
uniprot id: A0A8M9QAG4
uniprot id: A0A8M9QAG8
uniprot id: A0A8M9QFJ3
uniprot id: I3IRV8
uniprot id: I3IS53
uniprot id: I3ITI8
uniprot id: Q1JPU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

7955:orc2
gene id: 7955:orc2
uniprot id: Q08BP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC2 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Component of the origin recognition complex (ORC).
messages: Nucleus

7955:coa5
gene id: 7955:coa5
uniprot id: B0S740
names: Function
names: Similarity
messages: Belongs to the PET191 family.
messages: Involved in an early step of the mitochondrial complex IV assembly process.

7955:reep2
gene id: 7955:reep2
uniprot id: A0A8M2BKF7
uniprot id: Q4KMI4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DP1 family.
messages: Interacts with odorant receptor proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May enhance the cell surface expression of odorant receptors.
messages: Membrane

7955:mmp24
gene id: 7955:mmp24
uniprot id: E9QIX9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

7955:trak2
gene id: 7955:trak2
uniprot id: A0A0R4IDG7
uniprot id: A0A2R8Q3P3
uniprot id: A0A2R8RYY2
uniprot id: A0A8M2BJY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

7955:tspy
gene id: 7955:tspy
uniprot id: A0A8M2BEB9
uniprot id: Q6PFI8
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

7955:si:ch73-335m24.5
gene id: 7955:si:ch73-335m24.5
uniprot id: A0A8M9PND5
uniprot id: A0A8M9QL19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

7955:golt1bb
gene id: 7955:golt1bb
uniprot id: Q4V8Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

7955:dlg5a
gene id: 7955:dlg5a
uniprot id: A0A8M2B3K9
uniprot id: A0A8M3BEL3
uniprot id: B7ZC95
uniprot id: E7EXQ0
names: Similarity
messages: Belongs to the MAGUK family.

7955:cdip1
gene id: 7955:cdip1
uniprot id: A6H8U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

7955:ercc1
gene id: 7955:ercc1
uniprot id: Q6NY87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERCC1/RAD10/SWI10 family.
messages: Nucleus

f1
gene id: 7955:il17a/f1
uniprot id: Q5TKT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

7955:rad52
gene id: 7955:rad52
uniprot id: F1QXE3
uniprot id: Q4U0V2
names: Similarity
messages: Belongs to the RAD52 family.

7955:sf3a2
gene id: 7955:sf3a2
uniprot id: Q7ZVD4
names: Similarity
messages: Belongs to the SF3A2 family.

7955:osxm
gene id: 7955:osxm
uniprot id: F1R7W6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

7955:bicc2
gene id: 7955:bicc2
uniprot id: Q6R5A4
names: Similarity
messages: Belongs to the BicC family.

7955:rhol
gene id: 7955:rhol
uniprot id: A4FUN8
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Contains one covalently linked retinal chromophore.
messages: Membrane

7955:nubp2
gene id: 7955:nubp2
uniprot id: F1REW2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains.

7955:LOC566574
gene id: 7955:LOC566574
uniprot id: A0A8M9PL17
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:LOC100334365
gene id: 7955:LOC100334365
uniprot id: A0A8M1RDA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

7955:gtf3c5
gene id: 7955:gtf3c5
uniprot id: E7EZ29
names: Subcellular Location Annotation
messages: Nucleus

7955:LOC101886133
gene id: 7955:LOC101886133
uniprot id: A0A2R8S099
names: Similarity
messages: Belongs to the peptidase C14A family.

7955:atad2b
gene id: 7955:atad2b
uniprot id: E7FE14
names: Similarity
messages: Belongs to the AAA ATPase family.

7955:sike1
gene id: 7955:sike1
uniprot id: A0A0R4ISE8
uniprot id: A0A8M3AN84
names: Similarity
messages: Belongs to the SIKE family.

7955:plppr4a
gene id: 7955:plppr4a
uniprot id: F1R7P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

7955:ppm1f
gene id: 7955:ppm1f
uniprot id: A2BE49
names: Similarity
messages: Belongs to the PP2C family.

7955:tarsl2
gene id: 7955:tarsl2
uniprot id: A0A8M9PA82
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

7955:irx1b
gene id: 7955:irx1b
uniprot id: Q90YN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

7955:ripply3
gene id: 7955:ripply3
uniprot id: B2GSE0
uniprot id: Q2WG78
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus
messages: Probable transcriptional regulator involved in developmental processes.
messages: The Ripply homology domain and the WRPW motif are both necessary for its transcriptional corepressor activity on the transcription activator TBX1.
messages: The WRPW motif is required for binding to tle/groucho proteins.

7955:march5l
gene id: 7955:march5l
uniprot id: Q6NYK8
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control.
messages: Mitochondrion outer membrane
messages: The RING-CH-type zinc finger domain is required for E3 ligase activity.

7955:rdh8b
gene id: 7955:rdh8b
uniprot id: F1QT23
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:qtrt1
gene id: 7955:qtrt1
uniprot id: Q7SYK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit qtrt1 and an accessory subunit qtrt2.
messages: Mitochondrion outer membrane

7955:zgc:100920
gene id: 7955:zgc:100920
uniprot id: Q6DEK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

7955:gpia
gene id: 7955:gpia
uniprot id: Q8QFU2
names: Similarity
messages: Belongs to the GPI family.

7955:slc9a3r1a
gene id: 7955:slc9a3r1a
uniprot id: Q6P2U7
names: Function
names: Subcellular Location Annotation
messages: Endomembrane system
messages: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.

7955:slc7a9
gene id: 7955:slc7a9
uniprot id: F1QGJ2
names: Subcellular Location Annotation
messages: Membrane

7955:zgc:91968
gene id: 7955:zgc:91968
uniprot id: Q6GQM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the melanoregulin family.
messages: Cytoplasmic vesicle membrane
messages: Lysosome membrane
messages: Melanosome membrane
messages: Probably functions as cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell. Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate.

7955:snrpe
gene id: 7955:snrpe
uniprot id: Q7ZUG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, snrpb, snrpd1, snrpd2, snrpd3, snrpe, snrpf and snrpg that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins snrpb, snrpd1, snrpd2, snrpd3, snrpe, snrpf and snrpg, and at least three U1 snRNP-specific proteins snrnp70/u1-70k, snrpa/u1-a and snrpc/u1-c. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least prpf3, prpf4, prpf6, prpf8, prpf31, snrnp200, txnl4a, snrnp40, snrpb, snrpd1, snrpd2, snrpd3, snrpe, snrpf, snrpg, ddx23, cd2bp2, ppih, snu13, eftud2, sart1 and usp39, plus lsm2, lsm3, lsm4, lsm5, lsm6, lsm7 and lsm8. Component of the U7 snRNP complex, or U7 Sm protein core complex, that is composed of the U7 snRNA and at least lsm10, lsm11, snrpb, snrpd3, snrpe, snrpf and snrpg; the complex does not contain snrpd1 and snrpd2. Component of the minor spliceosome, which splices U12-type introns. Part of the SMN-Sm complex that contains smn1, gemin2/sip1, ddx20/gemin3, gemin4, gemin5, gemin6, gemin7, gemin8, strap/unrip and the Sm proteins snrpb, snrpd1, snrpd2, snrpd3, snrpe, snrpf and snrpg; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of clns1a/pICln, snrpd1, snrpd2, snrpe, snrpf and snrpg; ring-like structure where clns1a/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

7955:LOC110437787
gene id: 7955:LOC110437787
uniprot id: A0A8M9PQR4
names: Similarity
messages: Belongs to the HARBI1 family.

7955:parp6b
gene id: 7955:parp6b
uniprot id: A0A8M6Z4I1
uniprot id: F1R1Q8
names: Similarity
messages: Belongs to the ARTD/PARP family.

7955:armc1l
gene id: 7955:armc1l
uniprot id: F1R385
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.
messages: Membrane
messages: Mitochondrion outer membrane

7955:mcoln3b
gene id: 7955:mcoln3b
uniprot id: A0A8M9P5Q1
uniprot id: A0A8M9PLH2
uniprot id: A0A8M9PTT0
uniprot id: A0A8M9PX65
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

7955:si:ch211-133l5.7
gene id: 7955:si:ch211-133l5.7
uniprot id: A0A8N7UYV2
names: Subcellular Location Annotation
messages: Membrane

7955:snx11
gene id: 7955:snx11
uniprot id: A0A8M9PW72
uniprot id: Q1ED00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

7955:cav2
gene id: 7955:cav2
uniprot id: Q6IQM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

7955:si:dkey-58b18.7
gene id: 7955:si:dkey-58b18.7
uniprot id: A0A8M3AX95
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.

7955:mex3b
gene id: 7955:mex3b
uniprot id: A2RRV6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7955:helt
gene id: 7955:helt
uniprot id: Q6QB00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEY family.
messages: Nucleus
messages: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3'.

7955:gas6
gene id: 7955:gas6
uniprot id: Q7T3H4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:dolk
gene id: 7955:dolk
uniprot id: A4IG63
names: Similarity
messages: Belongs to the polyprenol kinase family.

7955:trim35-10
gene id: 7955:trim35-10
uniprot id: A0A8M1QHK9
names: Subcellular Location Annotation
messages: Cytoplasm

7955:rbfox1l
gene id: 7955:rbfox1l
uniprot id: A0A8M2B4J5
uniprot id: A0A8M9P7V7
uniprot id: B3DK66
uniprot id: Q7ZT82
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed during muscle development in adaxial cells, somites, cardiac precursors, finbuds and jaw muscle cells.
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events by binding to 5'-GCAUG-3' elements. Regulates alternative splicing of tissue-specific exons.
messages: RNA-binding protein that regulates alternative splicing events.

7955:tax1bp1b
gene id: 7955:tax1bp1b
uniprot id: Q6P132
names: Domain
names: Function
names: Tissue Specificity
messages: Expressed at relatively high levels in both proximal and distal regions of the fin bud during pectoral fin development.
messages: May have anti-apoptotic activity.
messages: The C-terminal UBZ-type zinc fingers function as ubiquitin-binding domains.

7955:impdh1b
gene id: 7955:impdh1b
uniprot id: A0A8M2BBW1
uniprot id: A0A8M2BC24
uniprot id: Q5RGV0
uniprot id: Q5RGV1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

7955:hsd17b2
gene id: 7955:hsd17b2
uniprot id: A0A8M2BAC5
uniprot id: Q1PLL0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:kctd3
gene id: 7955:kctd3
uniprot id: F1Q6W0
names: Similarity
messages: Belongs to the KCTD3 family.

7955:efna5b
gene id: 7955:efna5b
uniprot id: B3DH39
uniprot id: P79728
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the epha3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor epha2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation (By similarity). Controls axon growth and may be involved in the creation of the retino-tectal map.
messages: Expressed in the presumptive midbrain of developing embryos from the six-somite stage. By 24 hours, strongly expressed in the midbrain caudal to the presumptive tectum. At later stages, maintained at the posterior margin of the tectum.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Widespread expression in the embryo.

7955:pbx3b
gene id: 7955:pbx3b
uniprot id: A0A8M3AV99
uniprot id: A0A8M3AVA3
uniprot id: A0A8M3AVA6
uniprot id: A0A8M3B234
uniprot id: A0A8M3B506
uniprot id: A0A8M3BBW5
uniprot id: A0A8M6Z257
uniprot id: A4UU10
uniprot id: B0V334
uniprot id: Q9I9B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

7955:cfl2
gene id: 7955:cfl2
uniprot id: Q6NZW3
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

7955:kcng1
gene id: 7955:kcng1
uniprot id: A8WG04
names: Subcellular Location Annotation
messages: Membrane

7955:aspa
gene id: 7955:aspa
uniprot id: A8KB34
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AspA/AstE family. Aspartoacylase subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate.
messages: Cytoplasm
messages: Nucleus

7955:ribc1
gene id: 7955:ribc1
uniprot id: F1R3H7
names: Similarity
messages: Belongs to the RIB43A family.

7955:dmd
gene id: 7955:dmd
uniprot id: A0A0R4IXX0
uniprot id: A0A8M6YYV3
uniprot id: A0A8M6Z645
uniprot id: A0A8M9PJA8
uniprot id: A0A8M9PWR0
uniprot id: A0A8M9Q2H9
uniprot id: A0A8M9Q7T4
uniprot id: A0A8M9QD77
names: Function
names: Subcellular Location Annotation
messages: May play a role in anchoring the cytoskeleton to the plasma membrane.
messages: cytoskeleton

7955:nmur1b
gene id: 7955:nmur1b
uniprot id: A0A8N7URE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

7955:LOC100333484
gene id: 7955:LOC100333484
uniprot id: A0A8M9PTU0
uniprot id: A0A8M9Q6B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

7955:wnt7bb
gene id: 7955:wnt7bb
uniprot id: A0A8M6YYK6
uniprot id: X1WEJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

7955:LOC108179554
gene id: 7955:LOC108179554
uniprot id: A0A8M6YVC0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

7955:or109-4
gene id: 7955:or109-4
uniprot id: Q2PRK0
names: Subcellular Location Annotation
messages: Membrane

7955:ets2
gene id: 7955:ets2
uniprot id: Q501S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

7955:llph
gene id: 7955:llph
uniprot id: A7MBY1
uniprot id: Q3B748
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the learning-associated protein family.
messages: Chromosome
messages: Regulates dendritic and spine growth and synaptic transmission.
messages: nucleolus

7955:cldnc
gene id: 7955:cldnc
uniprot id: Q90XR2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the claudin family.
messages: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
messages: Cell membrane
messages: Membrane
messages: tight junction

7955:grpr
gene id: 7955:grpr
uniprot id: E7F6G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:tpra1
gene id: 7955:tpra1
uniprot id: Q4V8X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0359 family.
messages: Membrane

7955:LOC100003741
gene id: 7955:LOC100003741
uniprot id: A0A2R8Q5E0
uniprot id: A0A8M6Z3E3
names: Caution
names: Similarity
messages: Belongs to the CRELD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC110440062
gene id: 7955:LOC110440062
uniprot id: A0A8M9QGT5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:cga
gene id: 7955:cga
uniprot id: Q6QX43
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer of an alpha and a beta chain.
messages: Secreted

7955:entpd5a
gene id: 7955:entpd5a
uniprot id: E7F8A7
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

7955:oxr1a
gene id: 7955:oxr1a
uniprot id: A0A8M9NZC8
uniprot id: A0A8M9PD70
uniprot id: A0A8M9PJL1
uniprot id: A0A8M9PMK0
uniprot id: A9JTH8
names: Similarity
messages: Belongs to the OXR1 family.

7955:alad
gene id: 7955:alad
uniprot id: Q568L9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
messages: Homooctamer; active form. Homohexamer; low activity form.

7955:brpf3a
gene id: 7955:brpf3a
uniprot id: A0A8M2BGP9
names: Subcellular Location Annotation
messages: Nucleus

7955:gdnfb
gene id: 7955:gdnfb
uniprot id: A0A8M3ARX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

7955:taar12g
gene id: 7955:taar12g
uniprot id: Q5QNP0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:sde2
gene id: 7955:sde2
uniprot id: A0A8M3AUU4
uniprot id: Q7T293
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDE2 family.
messages: Cytoplasm
messages: Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress (By similarity). SDE2 is cleaved following PCNA binding, and its complete degradation is necessary to allow S-phase progression following DNA damage (By similarity).
messages: Nucleus
messages: Plays a role in pre-mRNA splicing by facilitating excision of relatively short introns featuring weak 3'-splice sites (ss) and high GC content (By similarity). May recruit CACTIN to the spliceosome (By similarity).
messages: Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor (By similarity). Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118 (By similarity).
messages: The PIP-box (PCNA interacting peptide) motif mediates both the interaction with PCNA and cleavage of the SDE2 precursor by a deubiquitinating enzyme.
messages: The SAP domain is necessary for specific binding to DNA.
messages: The propeptide displays a ubiquitin-like fold.
messages: Upon binding to PCNA, the N-terminal UBL (ubiquitin-like) propeptide is cleaved at Gly-71 by an unidentified deubiquitinating enzyme; the resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner.

7955:hspb9
gene id: 7955:hspb9
uniprot id: A5JV82
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

7955:cox5ab
gene id: 7955:cox5ab
uniprot id: A0A0R4IVC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

7955:haus3
gene id: 7955:haus3
uniprot id: Q08CD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS3 family.
messages: spindle

7955:msh3
gene id: 7955:msh3
uniprot id: A0A288CFS8
uniprot id: A0A8M3B2S9
uniprot id: A2CEA8
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).

7955:LOC110439322
gene id: 7955:LOC110439322
uniprot id: A0A8M9PZX5
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:si:dkey-58f10.6
gene id: 7955:si:dkey-58f10.6
uniprot id: A0A8M1P3H3
uniprot id: A0A8M9Q3M1
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:nceh1a
gene id: 7955:nceh1a
uniprot id: Q6DKF1
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

7955:atp8b5a
gene id: 7955:atp8b5a
uniprot id: A0A8M9Q998
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

7955:zgc:158291
gene id: 7955:zgc:158291
uniprot id: A1A5W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

7955:slc4a2a
gene id: 7955:slc4a2a
uniprot id: A0A8M9PZ09
uniprot id: B0S7B8
uniprot id: Q3KVL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Membrane

7955:gabpa
gene id: 7955:gabpa
uniprot id: Q9I9E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

7955:lca5
gene id: 7955:lca5
uniprot id: A0A8M9P5L0
uniprot id: A0A8M9PFL3
uniprot id: A0A8M9PLA8
uniprot id: A0A8M9PTM7
uniprot id: A0A8M9PTN2
uniprot id: E9QG33
names: Similarity
messages: Belongs to the LCA5 family.

7955:p2rx5
gene id: 7955:p2rx5
uniprot id: B0R182
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

7955:slc26a5
gene id: 7955:slc26a5
uniprot id: Q7T2C4
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Electrogenic antiporter that exchanges sulfate or oxalate for chloride ion in a strictly coupled manner with a 1:1 stoichiometry (PubMed:17442754, PubMed:22399806). Adopts a dynamic conformation, which alternates between the exposure of the central binding site to the extra- and intracellular solutions leading to an inward-to-outward conformational transition during the transport cycle (By similarity). Generates voltage-dependent charge movements resembling to the non-linear capacitance (NLC) of the cell membrane, but which are not associated to electromotile activity (PubMed:17272340, PubMed:22399806).
messages: Expressed in hair cells of the auditory organs.
messages: Homodimer (By similarity). Interacts (via STAS domain) with CALM; this interaction is calcium-dependent (By similarity).
messages: Sulfate/chloride antiport activity is inhibited by salicylate; this inhibition is reversible.
messages: The anion-binding site in STAS domain is lacking (By similarity). The STAS domain mediates dimerization, with both STAS domains latched onto each other in a domain-swapped manner. The N-terminus domain is involved in dimerization such that each N-terminus domain embraces both STAS domains (By similarity). The transmembrane domain consists of 14 transmembrane segments organized in a 7(+)7 inverted repeat architecture that can be divided into two main helix bundles, the ''core'' domain and the ''gate'' domain (By similarity). The transmembrane regions are domain-swapped with the STAS domain containing N- and C-terminal cytoplasmic domains (By similarity).
messages: The anion-binding site that controls electromotility and associated charge movement in mammalian, corresponds to the central binding site of the anion transport pathway in non-mammalian.

7955:grin2ab
gene id: 7955:grin2ab
uniprot id: F1QDE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

7955:slc7a1
gene id: 7955:slc7a1
uniprot id: A0A2R8QFJ7
uniprot id: E7F0D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

7955:ndufs8a
gene id: 7955:ndufs8a
uniprot id: Q6P0T0
names: Similarity
messages: Belongs to the complex I 23 kDa subunit family.

7955:tyrp1a
gene id: 7955:tyrp1a
uniprot id: A0A8M9Q985
uniprot id: F1QEC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

7955:cox8a
gene id: 7955:cox8a
uniprot id: E9QFA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Membrane
messages: Mitochondrion inner membrane

7955:hsp70.3
gene id: 7955:hsp70.3
uniprot id: Q6PH56
names: Similarity
messages: Belongs to the heat shock protein 70 family.

7955:gna11b
gene id: 7955:gna11b
uniprot id: Q5RKP9
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

7955:rsg1
gene id: 7955:rsg1
uniprot id: A0A8M3BAH8
uniprot id: Q66JN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells (By similarity).
messages: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.
messages: cilium basal body

7955:si:dkey-205h13.1
gene id: 7955:si:dkey-205h13.1
uniprot id: A0A8M9P550
uniprot id: E7F188
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

7955:mmp11a
gene id: 7955:mmp11a
uniprot id: A0A8M9Q3Z2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

7955:fam131c
gene id: 7955:fam131c
uniprot id: A0A0R4IHI3
uniprot id: A0A8M3AVD7
uniprot id: Q4KMI3
names: Similarity
messages: Belongs to the FAM131 family.

7955:hadhaa
gene id: 7955:hadhaa
uniprot id: A7YT47
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

7955:LOC108179083
gene id: 7955:LOC108179083
uniprot id: A0A8M6Z8I5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:stk35
gene id: 7955:stk35
uniprot id: A0JMF9
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:rsph9
gene id: 7955:rsph9
uniprot id: Q5TYW6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flagellar radial spoke RSP9 family.
messages: Component of axonemal radial spoke complexes.
messages: Dysmotile olfactory pit cilia which have a normal beat frequency but an ineffective circular beat pattern. Effect can be rescued by coinjection of mouse Rsph9 mRNA (PubMed:19200523). Embryos with CRISPR-induced rsph9 null mutations exhibit a greatly diminished olfactory and neural ciliary motility, structural defects in neural and pronephric ciliary axonemes and an impaired initiation of startle response to acoustic stimulation (PubMed:27687975).
messages: Expressed in ciliated structures in the embryos namely, Kupffer's vesicle, pronephric ducts, otic placodes and ventral spinal cord (at protein level) (PubMed:27687975). Also expressed in the ventral midline of the midbrain primordium (at protein level) (PubMed:27687975).
messages: Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia (PubMed:19200523). Required for motility of olfactory and neural cilia and for the structural integrity of ciliary axonemes in both 9+0 and 9+2 motile cilia (PubMed:27687975). Essential for both the radial spoke head assembly and the central pair microtubule stability in ependymal motile cilia (By similarity).
messages: cilium axoneme
messages: flagellum axoneme
messages: kinocilium

7955:crabp2a
gene id: 7955:crabp2a
uniprot id: Q801Y4
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

7955:si:ch211-222l21.1
gene id: 7955:si:ch211-222l21.1
uniprot id: E7F290
names: Similarity
messages: Belongs to the pro/parathymosin family.

7955:arrb2b
gene id: 7955:arrb2b
uniprot id: A0A8M3AU12
uniprot id: A0A8M3B109
uniprot id: A0A8M3B3X5
uniprot id: Q7T2D2
names: Similarity
messages: Belongs to the arrestin family.

7955:nlgn4b
gene id: 7955:nlgn4b
uniprot id: D0EVX3
uniprot id: F1QK81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

7955:oxtr
gene id: 7955:oxtr
uniprot id: E4W699
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:nr0b2b
gene id: 7955:nr0b2b
uniprot id: A0A8M1Q7C6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7955:nek8
gene id: 7955:nek8
uniprot id: Q90XC2
names: Disease Annotation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
messages: Cytoplasm
messages: Defects in nek8 are the cause of polycystic kidney disease.
messages: Morpholino knockdown of the protein in the embryo causes ventral body curvature, pronephric cyst formation and laterality defects, including reversed heart looping.
messages: Required for renal tubular integrity.

7955:pskh1
gene id: 7955:pskh1
uniprot id: B2GSX9
uniprot id: Q501V0
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

7955:esyt1a
gene id: 7955:esyt1a
uniprot id: A0A8N7T801
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:mars2
gene id: 7955:mars2
uniprot id: E7F5M3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

7955:si:dkey-17e16.13
gene id: 7955:si:dkey-17e16.13
uniprot id: E9QH99
names: Subcellular Location Annotation
messages: Nucleus

7955:pon3.1
gene id: 7955:pon3.1
uniprot id: E7FFZ8
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

7955:phkg2
gene id: 7955:phkg2
uniprot id: F1QXS6
uniprot id: Q7ZYW8
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

7955:npsn
gene id: 7955:npsn
uniprot id: F1REP3
uniprot id: Q05AP0
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:si:ch211-261n11.8
gene id: 7955:si:ch211-261n11.8
uniprot id: A0A8M9Q3V8
uniprot id: A0A8M9QE45
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:esrra
gene id: 7955:esrra
uniprot id: A0A8M2B8J1
uniprot id: Q6Q6F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

7955:c3ar1
gene id: 7955:c3ar1
uniprot id: A0A8M3B303
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

7955:tgm1l4
gene id: 7955:tgm1l4
uniprot id: A0A8M9PWI0
uniprot id: Q4V9H9
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

7955:acot14
gene id: 7955:acot14
uniprot id: Q1ED28
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

7955:npffr2a
gene id: 7955:npffr2a
uniprot id: A2AV71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

7955:zc3h18
gene id: 7955:zc3h18
uniprot id: Q1LUE5
names: Subcellular Location Annotation
messages: Nucleus

7955:aldh18a1
gene id: 7955:aldh18a1
uniprot id: A0A8M3AYJ5
uniprot id: A0A8M3B4R7
uniprot id: A4IGC8
names: Similarity
messages: In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
messages: In the N-terminal section; belongs to the glutamate 5-kinase family.

7955:eno1a
gene id: 7955:eno1a
uniprot id: A0A2R8Q1X2
uniprot id: Q6IQP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

7955:foxq1a
gene id: 7955:foxq1a
uniprot id: A0A0R4IJS9
names: Subcellular Location Annotation
messages: Nucleus

7955:litaf
gene id: 7955:litaf
uniprot id: A0A8M3AR44
uniprot id: Q6GMG8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Cell membrane
messages: Cytoplasm
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Nucleus
messages: Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role in the nucleus in regulating the expression of numerous cytokines.
messages: The LITAF domain is stabilized by a bound zinc ion. The LITAF domain contains an amphipathic helix that mediates interaction with lipid membranes.

7955:dis3l
gene id: 7955:dis3l
uniprot id: A2RV18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNR ribonuclease family.
messages: Component of the RNA exosome complex.
messages: Cytoplasm
messages: Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.

7955:f10
gene id: 7955:f10
uniprot id: F1QLC3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:gabrr3a
gene id: 7955:gabrr3a
uniprot id: B3DIE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:rabac1
gene id: 7955:rabac1
uniprot id: Q6TNR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

7955:gch2
gene id: 7955:gch2
uniprot id: Q6IQV5
names: Similarity
messages: Belongs to the GTP cyclohydrolase I family.

7955:myo7aa
gene id: 7955:myo7aa
uniprot id: A0A8M9P9W0
uniprot id: Q9DGG9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:cblc
gene id: 7955:cblc
uniprot id: A0A8M9PD63
uniprot id: A0A8M9PMJ3
uniprot id: A9JRD3
uniprot id: F6PCP5
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

7955:ankrd52a
gene id: 7955:ankrd52a
uniprot id: Q502K3
names: Function
names: Subunit
messages: Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS).
messages: Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.

7955:susd4
gene id: 7955:susd4
uniprot id: E7FEC4
names: Disruption Phenotype
names: Subcellular Location Annotation
messages: Membrane
messages: Morpholino knockdown of the protein causes defects in development, abnormal locomotion and increased mortality. At 3 days postfertilization morphants have abnormally (delayed) developed eyes.

7955:tfip11
gene id: 7955:tfip11
uniprot id: F1QQ02
uniprot id: Q6DI35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFP11/STIP family.
messages: Identified in the spliceosome C complex.
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events.
messages: Nucleus

7955:smc1a
gene id: 7955:smc1a
uniprot id: E7F0X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

7955:zgc:174193
gene id: 7955:zgc:174193
uniprot id: A9JSY1
names: Similarity
messages: Belongs to the peptidase S1C family.

7955:lipib
gene id: 7955:lipib
uniprot id: A0A8M1Q7Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

7955:LOC101886340
gene id: 7955:LOC101886340
uniprot id: A0A8M2BLS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

7955:si:ch211-131k2.2
gene id: 7955:si:ch211-131k2.2
uniprot id: A0A8M9QEI7
uniprot id: A0A8M9QMR4
uniprot id: R4GDR9
names: Similarity
messages: Belongs to the tachykinin family.

7955:pmpca
gene id: 7955:pmpca
uniprot id: Q5U3T6
names: Similarity
messages: Belongs to the peptidase M16 family.

7955:nab1a
gene id: 7955:nab1a
uniprot id: A0A8M2B8H4
uniprot id: A0A8M3AM67
uniprot id: Q1LWI4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

7955:homezb
gene id: 7955:homezb
uniprot id: B3DJM1
names: Subcellular Location Annotation
messages: Nucleus

7955:si:dkey-178o16.4
gene id: 7955:si:dkey-178o16.4
uniprot id: E7F1C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane

7955:prkcba
gene id: 7955:prkcba
uniprot id: A0A8M2BI27
uniprot id: Q7T2C5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.
messages: Cytoplasm
messages: Membrane

7955:sars
gene id: 7955:sars
uniprot id: Q6DRC0
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:19423848). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:19423848). In the nucleus, binds to the vegfa core promoter and prevents myc binding and transcriptional activation by myc (PubMed:24940000). Thereby inhibits the production of vegfa and sprouting angiogenesis mediated by vegfa (PubMed:19423848, PubMed:19423847, PubMed:22353712, PubMed:24940000).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Morpholino knockdown causes aberrant angiogenesis with excessive intersegmental vessel branching, due to excessive expression of vegfa.
messages: Nucleus

7955:LOC108191522
gene id: 7955:LOC108191522
uniprot id: A0A8M6Z8I9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:mfsd4ab
gene id: 7955:mfsd4ab
uniprot id: A9JTG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

7955:cpb1
gene id: 7955:cpb1
uniprot id: A0A8M1NG52
uniprot id: F1QJN9
uniprot id: Q6NWD1
names: Similarity
messages: Belongs to the peptidase M14 family.

7955:slc25a3b
gene id: 7955:slc25a3b
uniprot id: A0A2R8RYH8
uniprot id: Q7ZV45
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with PPIF; the interaction is impaired by CsA.
messages: Membrane
messages: Mitochondrion inner membrane

7955:eif4enif1
gene id: 7955:eif4enif1
uniprot id: E7FDR0
uniprot id: Q5BL27
names: Subcellular Location Annotation
messages: Cytoplasm

7955:cx27.5
gene id: 7955:cx27.5
uniprot id: Q2VJ87
uniprot id: Q9DF29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

7955:cpne8
gene id: 7955:cpne8
uniprot id: E7F5X2
names: Similarity
messages: Belongs to the copine family.

7955:ptk6a
gene id: 7955:ptk6a
uniprot id: A0A8N7TED1
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

7955:dap3
gene id: 7955:dap3
uniprot id: A5PLH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS29 family.
messages: Mitochondrion

7955:apoc1
gene id: 7955:apoc1
uniprot id: E9QDI1
uniprot id: E9QFX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C1 family.
messages: Secreted

7955:psmd11a
gene id: 7955:psmd11a
uniprot id: F6P3G4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the proteasome subunit S9 family.
messages: Component of the lid subcomplex of the 19S proteasome regulatory particle complex (also named PA700 complex). The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits (By similarity).
messages: Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, psmd11a is required for proteasome assembly (By similarity).
messages: Nucleus
messages: cytosol

7955:gba3
gene id: 7955:gba3
uniprot id: Q502A1
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

7955:elp6
gene id: 7955:elp6
uniprot id: Q0P424
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ELP6 family.
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity).
messages: Component of the elongator complex.
messages: The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification.

7955:LOC103909395
gene id: 7955:LOC103909395
uniprot id: A0A8M9Q309
names: Subcellular Location Annotation
messages: Membrane

7955:xpo6
gene id: 7955:xpo6
uniprot id: Q8QHJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.
messages: Nucleus

7955:serpinf2a
gene id: 7955:serpinf2a
uniprot id: F6NQ58
names: Similarity
messages: Belongs to the serpin family.

7955:LOC110438804
gene id: 7955:LOC110438804
uniprot id: A0A8M9QF43
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:lifrb
gene id: 7955:lifrb
uniprot id: A8WH83
uniprot id: F1Q5F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

7955:si:ch211-51a6.2
gene id: 7955:si:ch211-51a6.2
uniprot id: F1QX88
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
messages: Secreted

7955:cul4a
gene id: 7955:cul4a
uniprot id: Q7T2C1
names: Similarity
messages: Belongs to the cullin family.

7955:syt14b
gene id: 7955:syt14b
uniprot id: A0A286Y918
uniprot id: A0A8M3AT24
uniprot id: A0A8M9PBT7
names: Similarity
messages: Belongs to the synaptotagmin family.

7955:sigmar1
gene id: 7955:sigmar1
uniprot id: A0A8M3B632
uniprot id: Q7ZWG9
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG2 family.
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.
messages: Homotrimer (By similarity).
messages: Homotrimer.
messages: May function in lipid transport from the endoplasmic reticulum and be involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. May regulate calcium efflux at the endoplasmic reticulum (By similarity).
messages: Membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: Sigma receptors are classified into two subtypes (Sigma-1 and Sigma-2) based on their different pharmacological profile.
messages: The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.
messages: Vesicle

7955:cnot3b
gene id: 7955:cnot3b
uniprot id: Q1LUD8
uniprot id: Q7ZVL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT2/3/5 family.
messages: Nucleus

7955:slc38a9
gene id: 7955:slc38a9
uniprot id: Q08BA4
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Amino acid transport activity is increased by sodium (PubMed:29872228). Transport of L-glutamine, leucine and tyrosine is increased by arginine binding (By similarity).
messages: Associated component of the Ragulator complex (By similarity). Associated component of the Rag GTPases heterodimers (RRAGA and RRAGC) (PubMed:33296665).
messages: Belongs to the amino acid/polyamine transporter 2 family. SLC38A9 subfamily.
messages: Expression is ubiquitous from the one-cell stage to 12 hours post-fertilization (hpf), restricted to the retina at 18, 24, and 30 hpf (PubMed:35457018). Expression encompasses the heart and midbrain region at 30 and 48 hpf. From 72 hpf to 5 dpf, the expression is restricted to the liver and gut (PubMed:35457018).
messages: Glycosylated.
messages: Homozygote knockout fishs for the SLC38A9 show no morphological difference at 12 and 24 hours post-fertilization (hpf) (PubMed:35457018). However, a quarter exhibit pericardial edema and small eyes at 48 hpf; the abnormal phenotypes became severe at 72 hpf (PubMed:35457018). The overall body length is decreased at 24 and 72 hpf (PubMed:35457018). While mutant larvae with development defects died at 4-7 dpf, those normally developed have the same viability as wide type and exhibit normal fertility (PubMed:35457018).
messages: Late endosome membrane
messages: Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids (By similarity). Acts as an arginine sensor (PubMed:33296665). Following activation by arginine binding, mediates transport of L-glutamine, leucine and tyrosine with high efficiency, and is required for the efficient utilization of these amino acids after lysosomal protein degradation (PubMed:33296665). However, the transport mechanism is not well defined and the role of sodium is not clear. Guanine exchange factor (GEF) that, upon arginine binding, stimulates GDP release from RRAGA and therefore activates the Rag GTPase heterodimer and the mTORC1 pathway in response to nutrient sufficiency (By similarity).
messages: Lysosome membrane
messages: The cytosolic N-terminus part of the protein mediates interaction with the Ragulator complex (By similarity). The cytosolic N-terminus part of the protein mediates interaction with the Rag GTPase heterodimer in a RRAGA GDP-loaded state dependent and leading to the GDP release and SLC38A9 dissociation from the activated Rag GTPase heterodimer, upon arginine binding (PubMed:33296665). The cytosolic N-terminus part of the protein exists at least in two distinct conformations; The first is when the N-terminus is bound snugly in the arginine binding site (in the absence of arginine, low luminal arginine state) and the second is where the N-terminus is released and the substrate-binding site is occupied by arginine (in the presence of arginine, high luminal arginine state) (PubMed:33296665).
messages: the CARC and CRAC motifs mediate binding to cholesterol.

7955:fgf10b
gene id: 7955:fgf10b
uniprot id: Q1XG75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Secreted

7955:rps6
gene id: 7955:rps6
uniprot id: Q6DHL6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

7955:bcl9l
gene id: 7955:bcl9l
uniprot id: A0A8M2B5R5
uniprot id: F8W4Z7
uniprot id: Q67FY3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Highly expressed during gastrulation.
messages: Nucleus
messages: Severe defects of trunk and tail development.
messages: Transcriptional regulator that may act as an activator (By similarity). Plays a role for mesoderm patterning in early embryogenesis.

7955:mef2b
gene id: 7955:mef2b
uniprot id: A0A8M3AXP2
uniprot id: J7HE56
names: Subcellular Location Annotation
messages: Nucleus

7955:tns1a
gene id: 7955:tns1a
uniprot id: A0A8M3ATA5
uniprot id: A0A8M3ATB1
uniprot id: A0A8M3B0D1
uniprot id: A0A8M3B3C3
uniprot id: A0A8M3B3C8
uniprot id: A0A8M3BAB4
uniprot id: A0A8M6YYV2
uniprot id: A0A8N7UR56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

7955:tmem184c
gene id: 7955:tmem184c
uniprot id: B8JIG9
names: Subcellular Location Annotation
messages: Membrane

7955:inpp5a
gene id: 7955:inpp5a
uniprot id: A0A8M9PYV7
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family.

7955:prkrip1
gene id: 7955:prkrip1
uniprot id: B2GRY3
uniprot id: Q568A0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRKRIP1 family.
messages: Component of the pre-catalytic and post-catalytic spliceosome complexes.
messages: Nucleus
messages: Required for pre-mRNA splicing as component of the spliceosome (By similarity). Binds double-stranded RNA (By similarity).
messages: nucleolus

7955:kars
gene id: 7955:kars
uniprot id: A0A0R4IC11
uniprot id: Q6DHE6
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

7955:zgc:77517
gene id: 7955:zgc:77517
uniprot id: Q6PHE4
names: Similarity
messages: Belongs to the intermediate filament family.

7955:LOC101882480
gene id: 7955:LOC101882480
uniprot id: A0A8M9PBL7
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

7955:gpc4
gene id: 7955:gpc4
uniprot id: B3DJ94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

7955:cnfn
gene id: 7955:cnfn
uniprot id: A0A8M6YTL9
names: Similarity
messages: Belongs to the cornifelin family.

7955:ptgr1
gene id: 7955:ptgr1
uniprot id: Q5PRB9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer or homodimer.

7955:si:ch211-195h23.3
gene id: 7955:si:ch211-195h23.3
uniprot id: A0A8M9PRS7
uniprot id: A0A8M9PRT1
uniprot id: A0A8M9Q4E9
uniprot id: A0A8M9QAI5
uniprot id: A0A8M9QAI8
uniprot id: A0A8M9QAJ2
uniprot id: A0A8M9QF56
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

7955:hsdl1
gene id: 7955:hsdl1
uniprot id: A5WWC6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Although it belongs to the SDR family, Phe-218 is present instead of the conserved Tyr which is an active site residue. It is therefore expected that this protein lacks oxidoreductase activity.
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
messages: Mitochondrion

7955:ccr12b.1
gene id: 7955:ccr12b.1
uniprot id: A0A8M9PLY8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:myofl
gene id: 7955:myofl
uniprot id: A0A8N7T5L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferlin family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

7955:thnsl2
gene id: 7955:thnsl2
uniprot id: Q2YDP8
names: Function
names: Similarity
messages: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity).
messages: Belongs to the threonine synthase family.

7955:lyrm5a
gene id: 7955:lyrm5a
uniprot id: Q503U1
names: Similarity
messages: Belongs to the complex I LYR family.

7955:pptc7a
gene id: 7955:pptc7a
uniprot id: Q5U3N5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Mitochondrion matrix
messages: Protein phosphatase which positively regulates biosynthesis of the ubiquinone, coenzyme Q (By similarity). Dephosphorylates the ubiquinone biosynthesis protein coq7 which is likely to lead to its activation (By similarity).

7955:efnb2a
gene id: 7955:efnb2a
uniprot id: B0CLY3
uniprot id: O73874
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ephrin family.
messages: Binds to the receptor tyrosine kinase ephb4.
messages: Cell membrane
messages: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with ephb4 may play a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration (By similarity).
messages: Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:rhebl1
gene id: 7955:rhebl1
uniprot id: Q08CD8
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

7955:gabrp
gene id: 7955:gabrp
uniprot id: A0A8M9Q4W7
uniprot id: A0A8M9QPJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:serhl
gene id: 7955:serhl
uniprot id: A2BGU9
names: Function
names: Similarity
messages: Belongs to the AB hydrolase superfamily.
messages: Probable serine hydrolase.

7955:adora2aa
gene id: 7955:adora2aa
uniprot id: Q29ST6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

7955:nog1
gene id: 7955:nog1
uniprot id: Q6NV45
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the noggin family.
messages: Homodimer.
messages: Secreted

7955:chst3b
gene id: 7955:chst3b
uniprot id: A8WFU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

7955:amt
gene id: 7955:amt
uniprot id: Q5XJA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

7955:uckl1a
gene id: 7955:uckl1a
uniprot id: A0A8M2BF24
uniprot id: B0S7A4
names: Similarity
messages: Belongs to the uridine kinase family.

7955:LOC798124
gene id: 7955:LOC798124
uniprot id: A0A8M6Z702
names: Similarity
messages: Belongs to the HARBI1 family.

7955:ccna2
gene id: 7955:ccna2
uniprot id: Q6NV43
uniprot id: Q98TA3
names: Function
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Essential for the control of the cell cycle at the G2/M (mitosis) transition.

7955:si:dkey-47k20.8
gene id: 7955:si:dkey-47k20.8
uniprot id: A0A8M9PMM6
uniprot id: A0A8N7T6Z6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:spc25
gene id: 7955:spc25
uniprot id: B0UYS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC25 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

7955:fzd1
gene id: 7955:fzd1
uniprot id: B3DJ49
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:tacr2
gene id: 7955:tacr2
uniprot id: F1QPL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:si:ch211-266g18.10
gene id: 7955:si:ch211-266g18.10
uniprot id: A0A8M9P0E4
uniprot id: A0A8M9P0E7
uniprot id: A0A8M9P0F1
uniprot id: A0A8M9P0F3
uniprot id: A0A8M9P0F7
uniprot id: A0A8M9P0G1
uniprot id: A0A8M9P0G6
uniprot id: A0A8M9P0H0
uniprot id: A0A8M9P0H5
uniprot id: A0A8M9P0H8
uniprot id: A0A8M9P9B2
uniprot id: A0A8M9P9B6
uniprot id: A0A8M9P9C2
uniprot id: A0A8M9P9C7
uniprot id: A0A8M9P9D1
uniprot id: A0A8M9P9D5
uniprot id: A0A8M9P9E0
uniprot id: A0A8M9P9E5
uniprot id: A0A8M9P9E9
uniprot id: A0A8M9P9F2
uniprot id: A0A8M9PEM2
uniprot id: A0A8M9PEM9
uniprot id: A0A8M9PEN3
uniprot id: A0A8M9PEN8
uniprot id: A0A8M9PEP3
uniprot id: A0A8M9PEP9
uniprot id: A0A8M9PEQ3
uniprot id: A0A8M9PEQ8
uniprot id: A0A8M9PER3
uniprot id: A0A8M9PER7
uniprot id: A0A8M9PL66
uniprot id: A0A8M9PL71
uniprot id: A0A8M9PL76
uniprot id: A0A8M9PL81
uniprot id: A0A8M9PL87
uniprot id: A0A8M9PL93
uniprot id: A0A8M9PL99
uniprot id: A0A8M9PLA4
uniprot id: A0A8M9PLB1
uniprot id: A0A8M9PLB6
uniprot id: A0A8M9PP88
uniprot id: A0A8M9PP95
uniprot id: A0A8M9PP99
uniprot id: A0A8M9PPA4
uniprot id: A0A8M9PPB3
uniprot id: A0A8M9PPB6
uniprot id: A0A8M9PPC3
uniprot id: A0A8M9PPC9
uniprot id: A0A8M9PPD6
uniprot id: A0A8M9PPE1
names: Subcellular Location Annotation
messages: Membrane
messages: Sarcoplasmic reticulum membrane

7955:ptprua
gene id: 7955:ptprua
uniprot id: A0A0R4IMC4
uniprot id: A0A2R8QCZ8
uniprot id: A0A2R8QPI2
uniprot id: A0A8M3AVF9
uniprot id: A0A8M3B3F6
uniprot id: F1Q6E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

7955:atxn3
gene id: 7955:atxn3
uniprot id: A0A0R4ITP2
uniprot id: A0A8M6YTS8
uniprot id: A0A8M9P030
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7955:pappaa
gene id: 7955:pappaa
uniprot id: M1XYM1
names: Caution
names: Similarity
messages: Belongs to the peptidase M43B family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:osr1
gene id: 7955:osr1
uniprot id: Q5XJQ7
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Odd C2H2-type zinc-finger protein family.
messages: Contrary to PubMed:17011543, which shows pronephric expression during tailbud and somitogenesis stages, PubMed:18787069 report that osr1 is not expressed in kidney tissue. Similarly, in the absence of osr1, PubMed:17011543 report a complete absence of kidney tissue, and pericardial edemas characteristic of renal failure, whereas PubMed:18787069 report a segment-specific defect in the proximal nephron, with the distal nephron relatively unaffected, and a compensatory increase in angioblast cell numbers in the same trunk region.
messages: Embryos show a down-regulation of early pronephric markers lhx1a/lim1 and pax2a/pax2.1, and subsequent kidney defects.
messages: Expressed in the germ ring mesendoderm and subsequently in the endoderm and intermediate mesoderm, prior to the expression of definitive kidney or blood markers. At 60 hpf, expressed in the glomerulus, in some patches in the eye and brain, and weakly in the pectoral fin buds.
messages: Nucleus
messages: Transcriptional repressor (By similarity). Regulates mesoderm versus endoderm differentiation during gastrulation to regulate kidney versus vascular cell fate. Acts upstream of pax2a in kidney development and functions in glomerular maturation, after podocyte specification.

7955:rsrc2
gene id: 7955:rsrc2
uniprot id: Q6NWI1
names: Similarity
messages: Belongs to the RSRC2 family.

7955:or118-3
gene id: 7955:or118-3
uniprot id: Q2PRD8
names: Subcellular Location Annotation
messages: Membrane

7955:aldh3b1
gene id: 7955:aldh3b1
uniprot id: Q7ZU10
uniprot id: Q90ZZ7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

7955:kcnj3b
gene id: 7955:kcnj3b
uniprot id: E7F1N1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

7955:kifc3
gene id: 7955:kifc3
uniprot id: A0A8M2B5V3
uniprot id: A0A8M3AJU8
uniprot id: A0A8M3AKN3
uniprot id: A0A8M3AS77
uniprot id: A0A8M3AV59
uniprot id: A0A8M3B361
uniprot id: A0A8M9PAK5
uniprot id: A0A8M9PFZ6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:stk38l
gene id: 7955:stk38l
uniprot id: Q5RH05
uniprot id: Q803H3
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:b3gat3
gene id: 7955:b3gat3
uniprot id: F8W289
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:tek
gene id: 7955:tek
uniprot id: A0A8M3ARU2
uniprot id: A0A8M9PX37
uniprot id: O73791
names: Activity Regulation
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Angiopoietin binding leads to receptor dimerization and activation by autophosphorylation at Tyr-984 on the kinase activation loop.
messages: Autophosphorylated on tyrosine residues in response to ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Autophosphorylation occurs in a sequential manner, where Tyr-984 in the kinase activation loop is phosphorylated first, followed by autophosphorylation at additional tyrosine residues. Phosphorylation is important for interaction with scaffold proteins and effectors.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
messages: Cell junction
messages: Cell membrane
messages: Expressed in most populations of endothelial cells in 24 hours embryos. Not present in intersegmental vessels.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Tyrosine-protein kinase that acts as cell-surface receptor for angiopoietins and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Can activate or inhibit angiogenesis, depending on the context. Angiopoietin signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors (By similarity).
messages: cytoskeleton
messages: focal adhesion

7955:cwc15
gene id: 7955:cwc15
uniprot id: A5WV15
names: Similarity
messages: Belongs to the CWC15 family.

7955:myh10
gene id: 7955:myh10
uniprot id: A0A8M3AT40
uniprot id: A0A8M3B359
uniprot id: A0A8M3BA62
uniprot id: A0A8N7USR7
uniprot id: F1R3G4
uniprot id: I3ISA3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:kcnv2b
gene id: 7955:kcnv2b
uniprot id: A2ARG8
names: Subcellular Location Annotation
messages: Membrane

7955:itih6
gene id: 7955:itih6
uniprot id: A0A8M3AYJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

7955:psmb3
gene id: 7955:psmb3
uniprot id: Q7ZUJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

7955:smarcd3b
gene id: 7955:smarcd3b
uniprot id: A0A8M2BDT5
uniprot id: A0A8M2BDZ5
uniprot id: A0A8M9Q1P6
uniprot id: A0A8M9Q7X8
uniprot id: B2KL77
names: Similarity
messages: Belongs to the SMARCD family.

7955:ndc80
gene id: 7955:ndc80
uniprot id: Q6DRJ7
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. May play a role in chromosome congression and may be essential for the end-on attachment of the kinetochores to spindle microtubules.
messages: Artifact. Missing internal sequence that doesn't correspond to an exon-intron boundary.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex, which is composed of ndc80, cdca1, spbc24 and spbc25.
messages: Nucleus
messages: kinetochore

7955:e2f8
gene id: 7955:e2f8
uniprot id: F1QZ88
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as e2f1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes (By similarity). Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator and promoting expression of vegfa.
messages: Belongs to the E2F/DP family.
messages: Embryos lacking both e2f7 and e2f8 contain multiple intersegmental arteries that completely fail to migrate from the dorsal aorta. Gross morphology of these embryos and initial formation of main axial vessels are unaltered.
messages: Homodimer and heterodimer: mainly forms homodimers and, to a lesser extent, heterodimers with e2f7.
messages: In contrast to classical members of the E2F transcription factor, atypical members contain 2 DNA-binding domains and regulate transcription in a DP-independent manner. Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer (By similarity).
messages: Nucleus

7955:kcng3
gene id: 7955:kcng3
uniprot id: A0A8M9QJ67
names: Subcellular Location Annotation
messages: Membrane

7955:tmem186
gene id: 7955:tmem186
uniprot id: A0A8M2B8X3
uniprot id: B3DI94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM186 family.
messages: May be required for efficient assembly of the mitochondrial complex I.
messages: Membrane
messages: Mitochondrion inner membrane

7955:nasp
gene id: 7955:nasp
uniprot id: A0A8M9PMB8
uniprot id: A0A8M9QAI4
uniprot id: F1QNE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NASP family.
messages: Nucleus

7955:tnfsf13
gene id: 7955:tnfsf13
uniprot id: D2DMJ8
names: Similarity
messages: Belongs to the tumor necrosis factor family.

7955:cul5b
gene id: 7955:cul5b
uniprot id: A0A0R4IGP7
uniprot id: A0A8M3ALI0
uniprot id: A0A8M3ATW9
uniprot id: A0A8M3B4Q9
uniprot id: F1QFY1
names: Similarity
messages: Belongs to the cullin family.

7955:si:ch73-287m6.1
gene id: 7955:si:ch73-287m6.1
uniprot id: A0A8M3ALH0
uniprot id: A0A8M9P3P7
uniprot id: A0A8M9P3Q2
uniprot id: A0A8M9PD72
uniprot id: A0A8M9PD77
uniprot id: A0A8M9PR10
uniprot id: A0A8M9PUK1
names: Similarity
messages: Belongs to the RIMBP family.

7955:cdx1a
gene id: 7955:cdx1a
uniprot id: Q8AXR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

7955:xpo1b
gene id: 7955:xpo1b
uniprot id: A0A8M9PPG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

7955:si:ch211-240g9.1
gene id: 7955:si:ch211-240g9.1
uniprot id: A0A8M1PZR2
names: Similarity
messages: Belongs to the TAFA family.

7955:cyp46a1.1
gene id: 7955:cyp46a1.1
uniprot id: A0A8M3AKM7
uniprot id: Q504G3
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:dpm1
gene id: 7955:dpm1
uniprot id: Q6DEJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

7955:snap23.1
gene id: 7955:snap23.1
uniprot id: A0A8M2B5L7
uniprot id: A0A8M9PE44
uniprot id: Q7ZVE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: synaptosome

7955:apoa4b.1
gene id: 7955:apoa4b.1
uniprot id: Q3B7G4
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

7955:arv1
gene id: 7955:arv1
uniprot id: A8WFV2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane

7955:dpcd
gene id: 7955:dpcd
uniprot id: A0A8M6YXS0
uniprot id: Q0P448
names: Similarity
messages: Belongs to the DPCD family.

7955:rqcd1
gene id: 7955:rqcd1
uniprot id: Q6NWL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CNOT9 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors. May play a role in cell differentiation.
messages: Homodimer. Component of the CCR4-NOT complex (By similarity).
messages: Nucleus
messages: P-body

7955:kcnj3a
gene id: 7955:kcnj3a
uniprot id: E7F2Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

7955:tgfbi
gene id: 7955:tgfbi
uniprot id: Q7T1R2
names: Subcellular Location Annotation
messages: extracellular matrix

7955:glra3
gene id: 7955:glra3
uniprot id: A0A8M9Q7Y2
uniprot id: Q90W14
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

7955:slc46a3
gene id: 7955:slc46a3
uniprot id: A0A8M3AWN8
names: Subcellular Location Annotation
messages: Membrane

7955:gpn3
gene id: 7955:gpn3
uniprot id: Q6ZM63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Heterodimer with gpn1. Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.

7955:fam20ca
gene id: 7955:fam20ca
uniprot id: A0A8M3B8M1
names: Similarity
messages: Belongs to the FAM20 family.

7955:serpina1
gene id: 7955:serpina1
uniprot id: A0A8M6YU45
uniprot id: Q5SPJ4
names: Similarity
messages: Belongs to the serpin family.

7955:pth2
gene id: 7955:pth2
uniprot id: Q8QGA2
names: Developmental Stage
names: Function
names: Induction
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parathyroid hormone family.
messages: Detected at the cleavage and blastula stages, 1.75-4 hours post-fertilization (hpf) (PubMed:21880859). Expressed in forebrain, midbrain, hindbrain and cells lining the brain ventricles at 19-22 hpf (PubMed:21880859). Expressed in midbrain and otic vesicles at 26-36 hpf (PubMed:21880859). Detected in bilateral domains in brain near the hypothalamus, and in heart, at 48-72 hpf (PubMed:15297442, PubMed:21880859).
messages: Plays a role as a potent and selective agonist of pth2r resulting in adenyl cyclase activation and intracellular calcium level elevation.
messages: Secreted
messages: Unlikely isoform. Aberrant splice sites.
messages: Up-regulated in the developing brain by shh signaling.

7955:irx1a
gene id: 7955:irx1a
uniprot id: Q8JH33
uniprot id: Q90XQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

7955:uba2
gene id: 7955:uba2
uniprot id: A0A8M3ANZ0
uniprot id: A0A8M3AWE5
uniprot id: B2GQ09
uniprot id: Q7SXG4
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ubiquitin-activating E1 family.
messages: Cytoplasm
messages: Expressed in eye, brain and pectoral fins.
messages: Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.
messages: Heterodimer of sae1 and uba2/sae2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with ube2i (By similarity).
messages: Knockout animals show deficient growth, microcephaly, microphthalmia, mandibular hypoplasia and abnormal fins.
messages: Nucleus
messages: Sumoylated with SUMO1 and SUMO2/3 and by UBC9. Sumoylation at Lys-237 inhibits enzymatic activity. Sumoylation at the C-terminal lysine cluster plays an essential role in nuclear trafficking (By similarity).
messages: The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
messages: The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity).

7955:cyp2k20
gene id: 7955:cyp2k20
uniprot id: A0A8M9PP30
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:nf2b
gene id: 7955:nf2b
uniprot id: Q6Q413
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

7955:ppat
gene id: 7955:ppat
uniprot id: A6H8S4
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

7955:eef2k
gene id: 7955:eef2k
uniprot id: A0A8M2B219
uniprot id: A0A8M2B2E3
uniprot id: A0A8M2B2Y1
uniprot id: E7F318
uniprot id: Q6DGE0
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. Alpha-type protein kinase family.
messages: Monomer or homodimer.
messages: Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent.

7955:ghrh
gene id: 7955:ghrh
uniprot id: A0A181
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

7955:actn2b
gene id: 7955:actn2b
uniprot id: Q2YDR5
names: Similarity
messages: Belongs to the alpha-actinin family.

7955:gbx2
gene id: 7955:gbx2
uniprot id: Q8QGU1
names: Subcellular Location Annotation
messages: Nucleus

7955:iqsec1b
gene id: 7955:iqsec1b
uniprot id: A0A8M2BGL8
uniprot id: A0A8M2BGL9
uniprot id: A0A8M3AXM6
uniprot id: A0A8M3B6X9
uniprot id: A0A8M3BDQ3
uniprot id: A0A8M9PVJ2
uniprot id: E7EZE5
uniprot id: X1WBR0
names: Similarity
messages: Belongs to the BRAG family.

7955:lrrc51
gene id: 7955:lrrc51
uniprot id: A0A8M3AIT5
uniprot id: Q08C25
names: Subcellular Location Annotation
messages: Cytoplasm

7955:arl3
gene id: 7955:arl3
uniprot id: B2GR26
uniprot id: Q1MTE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Nucleus
messages: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Required for targeting proteins to the ciliary membrane by releasing myristoylated protein from unc119 cargo adapters into the cilium (By similarity).
messages: centrosome
messages: cilium
messages: spindle

7955:oxr1b
gene id: 7955:oxr1b
uniprot id: A0A8M2B610
uniprot id: F1Q4W8
uniprot id: I3ISS4
names: Similarity
messages: Belongs to the OXR1 family.

7955:LOC100151165
gene id: 7955:LOC100151165
uniprot id: A0A8M9Q338
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:cyp2r1
gene id: 7955:cyp2r1
uniprot id: F6P2A1
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:acp5b
gene id: 7955:acp5b
uniprot id: Q6DHF5
names: Cofactor
messages: Binds 2 iron ions per subunit.

7955:phox2a
gene id: 7955:phox2a
uniprot id: F1RCT9
uniprot id: Q6NYV4
names: Subcellular Location Annotation
messages: Nucleus

7955:dgkzb
gene id: 7955:dgkzb
uniprot id: A0A8M1RN59
uniprot id: A0A8M2BLI3
uniprot id: A0A8M2BLL1
uniprot id: A0A8M2BLW1
uniprot id: A0A8M9PVC2
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

7955:rgs12a
gene id: 7955:rgs12a
uniprot id: A0A8M3B3Z7
uniprot id: A0A8N7URF2
uniprot id: F1QV08
names: Subcellular Location Annotation
messages: Cytoplasm

7955:ppfibp1a
gene id: 7955:ppfibp1a
uniprot id: A0A0J9YJ57
uniprot id: Q5RG05
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

7955:sult1st2
gene id: 7955:sult1st2
uniprot id: Q7ZUS4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sulfotransferase 1 family.
messages: Cytoplasm
messages: Expressed in liver.
messages: Inhibited by Co(2+), Zn(2+), Cd(2+) and Pb(2+) ions. Inactivated by Hg(2+) and Cu(2+) ions.
messages: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a variety of xenobiotic and endogenous compounds, including 2-naphthol, hydroxychlorobiphenyls, T3 (triiodo-L-thyronine), T4 (thyroxine), estrone and DOPA.

7955:si:ch73-195i19.3
gene id: 7955:si:ch73-195i19.3
uniprot id: A0A8M9PYN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:LOC100001259
gene id: 7955:LOC100001259
uniprot id: A0A8M9PZF4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:si:ch211-276a23.5
gene id: 7955:si:ch211-276a23.5
uniprot id: E7F2N2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

7955:pkn1a
gene id: 7955:pkn1a
uniprot id: A0A8M2B6W9
uniprot id: A0A8N7T5U2
uniprot id: E9QCG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Nucleus

7955:ppm1la
gene id: 7955:ppm1la
uniprot id: A0JMP2
names: Similarity
messages: Belongs to the PP2C family.

7955:batf
gene id: 7955:batf
uniprot id: F1QW76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells.
messages: Belongs to the bZIP family.
messages: Cytoplasm
messages: Nucleus

7955:tmem50a
gene id: 7955:tmem50a
uniprot id: Q803R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

7955:taar14a
gene id: 7955:taar14a
uniprot id: Q5RFY4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:zbtb18
gene id: 7955:zbtb18
uniprot id: Q1L8W0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family. ZBTB18 subfamily.
messages: Nucleus
messages: Transcriptional repressor that plays a role in various developmental processes. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes (By similarity).

7955:eva1a
gene id: 7955:eva1a
uniprot id: A0A8M9P091
uniprot id: Q08CB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.
messages: Belongs to the EVA1 family.
messages: Endoplasmic reticulum membrane
messages: Lysosome membrane

7955:b4galt6
gene id: 7955:b4galt6
uniprot id: A0A8M2BHG8
uniprot id: Q802Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

7955:gh1
gene id: 7955:gh1
uniprot id: Q1JQ34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

7955:adora2ab
gene id: 7955:adora2ab
uniprot id: Q29ST5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

7955:abhd3
gene id: 7955:abhd3
uniprot id: Q66HU2
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

7955:arr3a
gene id: 7955:arr3a
uniprot id: Q6DH07
names: Similarity
messages: Belongs to the arrestin family.

7955:zgc:113019
gene id: 7955:zgc:113019
uniprot id: A0A8M9P3A4
uniprot id: Q566P6
names: Similarity
messages: Belongs to the HARBI1 family.

7955:nfil3-6
gene id: 7955:nfil3-6
uniprot id: Q6GPG2
names: Similarity
messages: Belongs to the bZIP family. NFIL3 subfamily.

7955:gnb4b
gene id: 7955:gnb4b
uniprot id: A0A2R8RKX9
uniprot id: Q5U3U8
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

7955:sh3bp5lb
gene id: 7955:sh3bp5lb
uniprot id: F1R096
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

7955:kcnd1
gene id: 7955:kcnd1
uniprot id: B0UYF4
names: Subcellular Location Annotation
messages: Membrane
messages: dendrite

7955:sept3
gene id: 7955:sept3
uniprot id: A2BGU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cytoplasm
messages: May be involved in cytokinesis.

7955:med27
gene id: 7955:med27
uniprot id: A0A8M9QDN3
uniprot id: B2GNU2
uniprot id: Q6PFL0
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 27 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for the development of dopaminergic amacrine cells in the retina. May also negatively regulate the development of rod photoreceptor cells.
messages: Component of the Mediator complex.
messages: Maternally expressed. Ubiquitously expressed throughout development.
messages: Nucleus

7955:ugt1a7
gene id: 7955:ugt1a7
uniprot id: D3XD58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7955:vars
gene id: 7955:vars
uniprot id: F1Q740
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

7955:tlr21
gene id: 7955:tlr21
uniprot id: F1QMN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

7955:akt1
gene id: 7955:akt1
uniprot id: M4MD44
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

7955:med4
gene id: 7955:med4
uniprot id: B2GPG1
uniprot id: Q561X3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

7955:zgc:112982
gene id: 7955:zgc:112982
uniprot id: A0A8M2B9X5
uniprot id: A0A8M3AVZ8
uniprot id: Q5CZU1
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

7955:ak1
gene id: 7955:ak1
uniprot id: A0A8M2BGJ7
uniprot id: Q68EH2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK1 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.

7955:taar20b
gene id: 7955:taar20b
uniprot id: A0A8M6Z0U9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:hhipl1
gene id: 7955:hhipl1
uniprot id: A0A8M9PE11
uniprot id: A4IG31
uniprot id: F6PEI8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:si:dkey-110c1.7
gene id: 7955:si:dkey-110c1.7
uniprot id: A0A8M3AMA8
uniprot id: A0A8M3AN14
uniprot id: A0A8M3AN19
uniprot id: A0A8M3AUQ9
uniprot id: A0A8M3AUR4
uniprot id: A0A8M3AXQ5
uniprot id: A0A8M3AXQ9
uniprot id: A0A8M3B5J4
uniprot id: A0A8M9PRV9
uniprot id: Q1LXS6
names: Subcellular Location Annotation
messages: Cytoplasm

7955:cpeb2
gene id: 7955:cpeb2
uniprot id: A0A8M1RRV8
uniprot id: A0A8M2BLD1
uniprot id: A0A8M3AMK6
uniprot id: A0A8M9PKW6
names: Similarity
messages: Belongs to the RRM CPEB family.

7955:dgat1b
gene id: 7955:dgat1b
uniprot id: A0A8M9NZ90
uniprot id: Q6DHG2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Homodimer or homotetramer; both forms have similar enzymatic activities.
messages: Membrane

7955:hrh1
gene id: 7955:hrh1
uniprot id: A0A8M3B6M8
uniprot id: Q195J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:tubgcp5
gene id: 7955:tubgcp5
uniprot id: F1QBQ4
uniprot id: Q503S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

7955:cyp3c2
gene id: 7955:cyp3c2
uniprot id: A0A8M6Z545
uniprot id: E9QEE5
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:si:dkey-202e22.2
gene id: 7955:si:dkey-202e22.2
uniprot id: A0A8N7UQX3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:fam228a
gene id: 7955:fam228a
uniprot id: A0A8M6Z3B1
uniprot id: A4IGE2
uniprot id: Q5RI30
names: Similarity
messages: Belongs to the FAM228 family.

7955:cul2
gene id: 7955:cul2
uniprot id: A0A8M9P612
names: Similarity
messages: Belongs to the cullin family.

7955:LOC100536949
gene id: 7955:LOC100536949
uniprot id: A0A8M9PZB0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:grm2a
gene id: 7955:grm2a
uniprot id: A0A8M2BDP3
uniprot id: U3N5X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

7955:tubb1
gene id: 7955:tubb1
uniprot id: E7FC32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

7955:ankrd13c
gene id: 7955:ankrd13c
uniprot id: Q7ZUV0
names: Function
names: Subcellular Location Annotation
messages: Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.
messages: Endoplasmic reticulum membrane

7955:eef2kmt
gene id: 7955:eef2kmt
uniprot id: A0A8M3B8A5
uniprot id: Q5XJN3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.

7955:unc13bb
gene id: 7955:unc13bb
uniprot id: A0A8M6Z8E2
uniprot id: A0A8M9PTX4
uniprot id: A0A8M9Q6D6
uniprot id: A0A8M9QCD0
uniprot id: A0A8M9QGV7
uniprot id: A0A8M9QGW1
uniprot id: A0A8M9QKX5
uniprot id: A0A8M9QKX9
names: Subcellular Location Annotation
messages: Cytoplasm

7955:art4
gene id: 7955:art4
uniprot id: E7F1D1
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

7955:tmpoa
gene id: 7955:tmpoa
uniprot id: A0A2R8Q454
uniprot id: A0A8M2BBX9
uniprot id: A0A8M2BC05
uniprot id: Q5RGX2
uniprot id: Q5RGX4
uniprot id: Q5RGX5
uniprot id: Q7ZTV0
names: Similarity
messages: Belongs to the LEM family.

7955:fam46c
gene id: 7955:fam46c
uniprot id: Q7ZUP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TENT family.
messages: Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression.
messages: Cytoplasm
messages: Nucleus
messages: centrosome

7955:prkd2
gene id: 7955:prkd2
uniprot id: A0A8M9PLD4
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

7955:adgre10
gene id: 7955:adgre10
uniprot id: F1QAE5
names: Subcellular Location Annotation
messages: Membrane

7955:agtr2
gene id: 7955:agtr2
uniprot id: Q5CZS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:mrpl34
gene id: 7955:mrpl34
uniprot id: E9QEZ5
uniprot id: E9QF21
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

7955:ryr3
gene id: 7955:ryr3
uniprot id: A0A8M3ALN1
uniprot id: A0A8M3ATC3
uniprot id: A0A8M3AWD0
names: Subcellular Location Annotation
messages: Membrane
messages: Sarcoplasmic reticulum membrane

7955:fbxl15
gene id: 7955:fbxl15
uniprot id: Q6NW95
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBXL15 family.
messages: Cytoplasm
messages: Maternally expressed. At 24 hours post-fertilization (hpf), expressed mainly in head region.
messages: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL15).
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Acts as a positive regulator of the BMP signaling pathway (By similarity). Required for dorsal/ventral pattern formation.

7955:ahsa1b
gene id: 7955:ahsa1b
uniprot id: Q7SXN3
names: Similarity
messages: Belongs to the AHA1 family.

7955:lbx1b
gene id: 7955:lbx1b
uniprot id: E7FDX5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: First expressed at the dorsal intermediate region of the neural tube at the 5-somite stage, expression is extended along the rostral caudal axis by the late stages of segmentation (PubMed:19216761). Expressed at the presumptive fin bud at 24 hours post-fertilization (hpf) and then at the fin bud at 48 hpf (PubMed:19216761).
messages: Morpholino knockdown results in decreased myod1 expression in the fin bud of embryos.
messages: Nucleus
messages: Transcription factor required for the development of hypaxial muscles.

7955:atoh7
gene id: 7955:atoh7
uniprot id: Q8AW52
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Expressed in the developing retina.
messages: Nucleus
messages: Perikaryon
messages: Transcription factor that binds to DNA at the consensus sequence 5'-CAG[GC]TG-3' (By similarity). Involved in the differentiation of retinal ganglion cells, photoreceptor population and optic nerve development (PubMed:10985346, PubMed:11430806). Required for retinal circadian rhythm photoentrainment (By similarity).
messages: axon

7955:kcnc3b
gene id: 7955:kcnc3b
uniprot id: A0A8M9P5Y6
uniprot id: A0A8M9PG37
uniprot id: A0A8M9PG40
uniprot id: A0A8M9PLW2
uniprot id: A0A8M9PU62
uniprot id: E1AZA6
names: Subcellular Location Annotation
messages: Membrane

7955:chmp7
gene id: 7955:chmp7
uniprot id: Q6PBQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF7 family.
messages: Cytoplasm
messages: ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway.
messages: Nucleus envelope

7955:nefma
gene id: 7955:nefma
uniprot id: F1QCR7
names: Similarity
messages: Belongs to the intermediate filament family.

7955:itgam
gene id: 7955:itgam
uniprot id: A0A8N7UVW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

7955:si:cabz01029535.1
gene id: 7955:si:cabz01029535.1
uniprot id: A0A140LFM6
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: At 5 dpf, expressed in larvae brain and spinal cord.
messages: Belongs to the MINAR family.
messages: Cell membrane
messages: Intrinsically disordered protein which may negatively regulate mTOR signaling pathway by stabilizing the mTOR complex component DEPTOR. Negatively regulates angiogenesis. Negatively regulates cell growth (By similarity). May play a role in neuronal development (PubMed:30080879).
messages: MINAR1 topology is a matter of debate, some authors think the N-terminus is extracellular, while preliminary experimental results suggest a cytosolic location.
messages: Mutant animals show no gross developmental abnormalities. They have enhanced fear-evoked freezing and compromised C-start responses. Mutant brains exhibit up-regulation of mTOR signaling.

7955:LOC110437794
gene id: 7955:LOC110437794
uniprot id: A0A8M6Z7J4
names: Subcellular Location Annotation
messages: Membrane

7955:or111-1
gene id: 7955:or111-1
uniprot id: O42170
names: Subcellular Location Annotation
messages: Membrane

7955:insra
gene id: 7955:insra
uniprot id: A0A8M2BIL6
uniprot id: B7SNG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

7955:zp3.2
gene id: 7955:zp3.2
uniprot id: Q4QRF0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPC subfamily.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

7955:mif
gene id: 7955:mif
uniprot id: Q0ZBR7
names: Similarity
messages: Belongs to the MIF family.

7955:cth1
gene id: 7955:cth1
uniprot id: Q9PU62
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

7955:LOC101887003
gene id: 7955:LOC101887003
uniprot id: A0A8M2BE27
names: Function
messages: Cadherins are calcium-dependent cell adhesion proteins.

7955:coq2
gene id: 7955:coq2
uniprot id: A3KNW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
messages: Mitochondrion inner membrane

7955:ier2a
gene id: 7955:ier2a
uniprot id: A0A0M3HEM8
names: Similarity
messages: Belongs to the IER family.

7955:get4
gene id: 7955:get4
uniprot id: F1R3Y3
names: Similarity
messages: Belongs to the GET4 family.

7955:serpinf2b
gene id: 7955:serpinf2b
uniprot id: A1A5Y8
names: Similarity
messages: Belongs to the serpin family.

7955:zgc:112332
gene id: 7955:zgc:112332
uniprot id: Q502C0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:si:dkey-23c22.5
gene id: 7955:si:dkey-23c22.5
uniprot id: A0A8M3BBS2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:rnf43
gene id: 7955:rnf43
uniprot id: A0A8M9Q3W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZNRF3 family.
messages: Cell membrane

7955:srp54
gene id: 7955:srp54
uniprot id: Q7ZVN5
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: At 26 hours post fertilization (hpf), expression is ubiquitous (PubMed:28972538). Later in development, expression is more pronounced in the anterior part (PubMed:28972538).
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: srp72, srp68, srp54, srp19, srp14 and srp9.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component srpra to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit srpra. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (By similarity). Requires the presence of srp9/srp14 and/or srp19 to stably interact with RNA (By similarity). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Mutants show profound reductions in neutrophil counts and chemotaxis as well as a diminished exocrine pancreas size.
messages: Nucleus speckle
messages: The M domain binds the 7SL RNA in presence of srp19 and binds the signal sequence of presecretory proteins.
messages: The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit srpra. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

7955:si:ch211-282j17.13
gene id: 7955:si:ch211-282j17.13
uniprot id: E7FA55
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:slc31a1
gene id: 7955:slc31a1
uniprot id: F1QKH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

7955:irak1bp1
gene id: 7955:irak1bp1
uniprot id: Q501X6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRAK1BP1 family.
messages: Cytoplasm
messages: May be part of a signaling pathway that leads to NF-kappa-B activation.
messages: Nucleus

7955:atf7a
gene id: 7955:atf7a
uniprot id: Q4VGW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

7955:zgc:174855
gene id: 7955:zgc:174855
uniprot id: A7MCR6
names: Similarity
messages: Belongs to the peptidase C1 family.

7955:adgrf8
gene id: 7955:adgrf8
uniprot id: A0A8M9PHL8
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:acot19
gene id: 7955:acot19
uniprot id: Q5U3W6
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

7955:ndrg1a
gene id: 7955:ndrg1a
uniprot id: A5WW18
uniprot id: Q6A3P5
names: Similarity
messages: Belongs to the NDRG family.

7955:porcn
gene id: 7955:porcn
uniprot id: A0A8M3B1X0
uniprot id: B0S7W7
names: Subcellular Location Annotation
messages: Membrane

7955:or106-11
gene id: 7955:or106-11
uniprot id: Q2PRK6
names: Subcellular Location Annotation
messages: Membrane

7955:ybey
gene id: 7955:ybey
uniprot id: A0A2R9YJM1
uniprot id: Q6NWH8
names: Similarity
messages: Belongs to the endoribonuclease YbeY family.

7955:si:dkey-49c17.3
gene id: 7955:si:dkey-49c17.3
uniprot id: A0A8M2B2E2
uniprot id: A0A8M2B321
uniprot id: A0A8N7T553
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin ligase.

7955:eme1
gene id: 7955:eme1
uniprot id: E7F6N8
names: Similarity
messages: Belongs to the EME1/MMS4 family.

7955:rho
gene id: 7955:rho
uniprot id: P35359
names: Caution
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Contains one covalently linked retinal chromophore.
messages: First detected at 51 hours post-fertilization (hpf) in the ventral retina. At 60 hpf, expressed in a strip across the ventrotemporal retina. By 96 hpf, also expressed in the dorsal retina.
messages: Membrane
messages: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
messages: Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity).
messages: Retinal rod photoreceptor cells, predominantly in the outer segments (at protein level) (PubMed:10349976). Retinal rod photoreceptor cells (PubMed:8327475, PubMed:8603882).
messages: Was originally (PubMed:8327475, PubMed:8924413) thought to be an ultraviolet-sensitive opsin present in short single cones.
messages: photoreceptor outer segment

7955:LOC110437768
gene id: 7955:LOC110437768
uniprot id: A0A8M9QDX1
names: Similarity
messages: Belongs to the dynein heavy chain family.

7955:cry1bb
gene id: 7955:cry1bb
uniprot id: A0A8M1PCZ5
uniprot id: A0A8M3AXA7
uniprot id: A0A8M9P4C5
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 FAD per subunit.

7955:prox1a
gene id: 7955:prox1a
uniprot id: F1QAE1
uniprot id: Q90ZL7
names: Subcellular Location Annotation
messages: Nucleus

7955:ptges3a
gene id: 7955:ptges3a
uniprot id: Q7SZQ8
names: Similarity
messages: Belongs to the p23/wos2 family.

7955:setd2
gene id: 7955:setd2
uniprot id: A0A8M9PJZ4
uniprot id: F1QJI9
names: Subcellular Location Annotation
messages: Nucleus

7955:eef1a1a
gene id: 7955:eef1a1a
uniprot id: Q6P969
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

7955:kcnn3
gene id: 7955:kcnn3
uniprot id: A0A8M3ATE4
uniprot id: E7FAT2
names: Subcellular Location Annotation
messages: Membrane

7955:ptena
gene id: 7955:ptena
uniprot id: A0A8M1PHN1
uniprot id: Q6PC66
uniprot id: Q6TGR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4.
messages: Belongs to the PTEN phosphatase protein family.
messages: Cytoplasm
messages: Nucleus
messages: PML body
messages: Postsynaptic density
messages: dendritic spine

7955:tor1l1
gene id: 7955:tor1l1
uniprot id: B3DJX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

7955:nrp1b
gene id: 7955:nrp1b
uniprot id: Q6T870
names: Caution
names: Similarity
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:atp1b4
gene id: 7955:atp1b4
uniprot id: E7F9R1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

7955:ep300a
gene id: 7955:ep300a
uniprot id: A0A8M3AYD6
uniprot id: A0A8M3AYE1
uniprot id: A0A8M3B4N4
uniprot id: A0A8M3B7G7
uniprot id: A0A8M3BE71
uniprot id: A0A8M3BE74
uniprot id: A0A8M9QMW4
names: Subcellular Location Annotation
messages: Cytoplasm

7955:ifnphi3
gene id: 7955:ifnphi3
uniprot id: A8E6E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

7955:tbp
gene id: 7955:tbp
uniprot id: Q7SXL3
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TBP family.
messages: Enriched in testis but hardly detectable in the ovary (at protein level).
messages: Expressed both maternally and zygotically. Expression is very low in the zygote, increasing from morula stage onward to reach a peak during early gastrulation. Levels then rapidly decline during neurula and organogenesis stages (at protein level). There is an inverse correlation between mRNA and protein levels at the late blastula and early gastrula stages.
messages: General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (By similarity). Members of the TBP family are differentially required for transcription and development during early embryogenesis. Regulates mRNA levels in the early embryo by both transcriptional and post-transcriptional mechanisms. Required for transcription of a subset of genes at the mid-blastula transition (MBT). Negatively regulates the expression of other embryonic genes, including autoregulation of the tbp promoter itself. Also functions within a transcription-dependent mechanism to direct the temporally-regulated degradation of a subset of maternal mRNAs after the MBT. This is part of a general mechanism to regulate the maternal to zygotic transition and is required for normal embryonic development. Binds to promoters of a subset of genes. Required for gastrulation.
messages: Nucleus

7955:phf5a
gene id: 7955:phf5a
uniprot id: Q6YMR2
names: Similarity
messages: Belongs to the PHF5 family.

7955:mapk1
gene id: 7955:mapk1
uniprot id: Q7ZW72
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

7955:ftcd
gene id: 7955:ftcd
uniprot id: A0A8M1PIL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds and promotes bundling of vimentin filaments originating from the Golgi.
messages: Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.
messages: Golgi apparatus
messages: Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure.
messages: In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.
messages: In the N-terminal section; belongs to the formiminotransferase family.
messages: centriole

7955:foxg1c
gene id: 7955:foxg1c
uniprot id: Q1LVK4
names: Subcellular Location Annotation
messages: Nucleus

7955:uprt
gene id: 7955:uprt
uniprot id: Q6NYU7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPRTase family.
messages: Cytoplasm
messages: Nucleus
messages: The uracil binding region known from UPRTases is missing.

7955:chl1a
gene id: 7955:chl1a
uniprot id: A0A8M3ANF3
uniprot id: A0A8M9PF48
uniprot id: E9QCF0
names: Similarity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

7955:tp53inp1
gene id: 7955:tp53inp1
uniprot id: A0PJS8
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

7955:rrad
gene id: 7955:rrad
uniprot id: A0A8M9PNL4
uniprot id: A0A8M9Q175
uniprot id: Q7SY56
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

7955:si:ch73-308m11.1
gene id: 7955:si:ch73-308m11.1
uniprot id: A0A8M1QQI5
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:si:dkey-17e16.9
gene id: 7955:si:dkey-17e16.9
uniprot id: A0A8M6YX78
names: Caution
names: Cofactor
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:guf1
gene id: 7955:guf1
uniprot id: A0A8M9QKS4
uniprot id: E7FFK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. LepA subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Mitochondrion inner membrane
messages: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.

7955:plk3
gene id: 7955:plk3
uniprot id: Q7ZVM4
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

7955:esr2a
gene id: 7955:esr2a
uniprot id: Q7ZU32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

7955:zgc:91944
gene id: 7955:zgc:91944
uniprot id: A0A8M3AKA5
uniprot id: F1RAA7
uniprot id: Q6DG34
names: Subcellular Location Annotation
messages: Nucleus

7955:lhfpl5b
gene id: 7955:lhfpl5b
uniprot id: A8KB64
uniprot id: B0UYJ1
names: Subcellular Location Annotation
messages: Membrane

7955:ppp4r2b
gene id: 7955:ppp4r2b
uniprot id: A1L1M4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PPP4R2 family.
messages: Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4).
messages: Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits.

7955:kcnmb2
gene id: 7955:kcnmb2
uniprot id: Q5BL22
names: Subcellular Location Annotation
messages: Membrane

7955:csgalnact2
gene id: 7955:csgalnact2
uniprot id: A0A8M1NHC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

7955:zgc:158403
gene id: 7955:zgc:158403
uniprot id: A1A5Y5
names: Similarity
messages: Belongs to the TTC39 family.

7955:zgc:103586
gene id: 7955:zgc:103586
uniprot id: A0A8M9Q7T7
uniprot id: Q5U3F7
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

7955:wnt6a
gene id: 7955:wnt6a
uniprot id: A0A8M1RQZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

7955:LOC101882185
gene id: 7955:LOC101882185
uniprot id: A0A8M2BIT1
names: Subunit
messages: Homodimer.

7955:LOC100536505
gene id: 7955:LOC100536505
uniprot id: A0A8M6Z0T4
names: Subcellular Location Annotation
messages: Cytoplasm

7955:ungb
gene id: 7955:ungb
uniprot id: E9QG27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
messages: Mitochondrion
messages: Nucleus

7955:cox6b2
gene id: 7955:cox6b2
uniprot id: Q7SXM1
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

7955:zic1
gene id: 7955:zic1
uniprot id: O93311
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

7955:camk1da
gene id: 7955:camk1da
uniprot id: B1H1J7
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:aste1b
gene id: 7955:aste1b
uniprot id: E7F2I2
names: Similarity
messages: Belongs to the asteroid family.

7955:zgc:162592
gene id: 7955:zgc:162592
uniprot id: A3KNW1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:stoml1
gene id: 7955:stoml1
uniprot id: A8KBI2
names: Similarity
messages: Belongs to the band 7/mec-2 family.

7955:pde6a
gene id: 7955:pde6a
uniprot id: Q800E7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

7955:cacul1
gene id: 7955:cacul1
uniprot id: A0A8M1RNS4
names: Similarity
messages: Belongs to the cullin family.

7955:zgc:92137
gene id: 7955:zgc:92137
uniprot id: Q6DHR7
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

7955:hif1an
gene id: 7955:hif1an
uniprot id: P59723
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer; homodimerization is essential for catalytic activity.
messages: Hydroxylates a specific Asn residue in the C-terminal transactivation domain (CAD) of HIF-1 alpha. The hydroxylation prevents interaction of HIF-1 with transcriptional coactivators. Also hydroxylates specific Asn, Asp and His residues within ankyrin repeat domain-containing proteins.
messages: Nucleus
messages: perinuclear region

7955:bco2l
gene id: 7955:bco2l
uniprot id: A0A8M9PKL8
uniprot id: Q90WH3
names: Cofactor
names: Similarity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.

7955:irak4
gene id: 7955:irak4
uniprot id: Q7ZVW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Cytoplasm
messages: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.

7955:si:ch211-242e8.1
gene id: 7955:si:ch211-242e8.1
uniprot id: A0A8N7TE33
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC101882154
gene id: 7955:LOC101882154
uniprot id: A0A8M2BLT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL family.
messages: Membrane

7955:si:ch211-126g16.11
gene id: 7955:si:ch211-126g16.11
uniprot id: B0UXE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:tsen34
gene id: 7955:tsen34
uniprot id: A0A8M9Q2Y0
uniprot id: A2BIL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

7955:ppp5c
gene id: 7955:ppp5c
uniprot id: A2VD35
uniprot id: F6NMN3
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.

7955:si:ch73-127m5.1
gene id: 7955:si:ch73-127m5.1
uniprot id: E7F8P5
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
messages: Secreted

7955:LOC108181627
gene id: 7955:LOC108181627
uniprot id: A3KPR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:btr01
gene id: 7955:btr01
uniprot id: F1QYX5
names: Subcellular Location Annotation
messages: Cytoplasm

7955:lhpp
gene id: 7955:lhpp
uniprot id: A5PLK2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Nucleus
messages: Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity).

7955:zgc:66313
gene id: 7955:zgc:66313
uniprot id: A0A8M2B5V6
uniprot id: Q7SYK9
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

7955:grik2
gene id: 7955:grik2
uniprot id: A0A8M9P836
uniprot id: A0A8M9PDB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

7955:ube2g1b
gene id: 7955:ube2g1b
uniprot id: Q7ZW32
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7955:ccl27a
gene id: 7955:ccl27a
uniprot id: A0A0R4IRX2
uniprot id: F1R6S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

7955:rbm15
gene id: 7955:rbm15
uniprot id: F1RCY7
names: Similarity
messages: Belongs to the RRM Spen family.

7955:szl
gene id: 7955:szl
uniprot id: Q7SX78
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:nxph4
gene id: 7955:nxph4
uniprot id: A0A8M3ATS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

7955:LOC563500
gene id: 7955:LOC563500
uniprot id: A0A8M3AUR0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:gpd1c
gene id: 7955:gpd1c
uniprot id: Q7T3H5
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

7955:six3a
gene id: 7955:six3a
uniprot id: O73708
names: Subcellular Location Annotation
messages: Nucleus

7955:pgam1a
gene id: 7955:pgam1a
uniprot id: Q7SZR4
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

7955:foxn2a
gene id: 7955:foxn2a
uniprot id: A0A8M1RLE7
names: Subcellular Location Annotation
messages: Nucleus

7955:ponzr6
gene id: 7955:ponzr6
uniprot id: E7FAV8
names: Similarity
messages: Belongs to the cornifelin family.

7955:gigfy2
gene id: 7955:gigfy2
uniprot id: Q4KME6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GIGYF family.
messages: Component of the 4EHP-GYF2 complex (By similarity).
messages: Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages.
messages: Maternally expressed: detected from the 1-cell stage, prior to the onset of zygotic expression. From blastula until gastrula stages, strongly expressed throughout the blastoderm. At 28 hours post-fertilization (hpf), highly expressed in the central nervous system (CNS), whereas a weaker expression is found in the somites. At later stages of development (48 hpf), expression persists in well-defined structures of the CNS, such as the diencephalon, the mesencephalon, the cerebellum and the rhombencephalon, and remains detectable in the somites.
messages: Morpholino knockdown show mild, intermediate, and severe phenotypes. Embryos with severe phenotype display a disrupted body pattern, embryos with intermediate phenotype show defects in the head and eye structures, while embryos with mild phenotype only show a twist in the terminal part of the tail. Embryos do not show important cell loss in diencephalic dopaminergic (DA) neuron clusters.

7955:slc16a1b
gene id: 7955:slc16a1b
uniprot id: Q7ZUL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

7955:csrnp3
gene id: 7955:csrnp3
uniprot id: A0A2R8RSH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

7955:zgc:153372
gene id: 7955:zgc:153372
uniprot id: Q08C90
names: Similarity
messages: Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.

7955:rxfp3.3a3
gene id: 7955:rxfp3.3a3
uniprot id: A0A8M9Q6X3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:crygmxl1
gene id: 7955:crygmxl1
uniprot id: Q4VBU1
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:sgcb
gene id: 7955:sgcb
uniprot id: Q3ZB93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.
messages: cytoskeleton
messages: sarcolemma

7955:tbx6l
gene id: 7955:tbx6l
uniprot id: A0A8M1PB76
uniprot id: A0A8M6YZ11
uniprot id: A0A8M6Z0I2
names: Subcellular Location Annotation
messages: Nucleus

7955:slc9a1a
gene id: 7955:slc9a1a
uniprot id: A0A8M2BKS9
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

7955:si:dkeyp-110e4.6
gene id: 7955:si:dkeyp-110e4.6
uniprot id: E9QJQ5
names: Similarity
messages: Belongs to the phospholipase D family.

7955:rpl5b
gene id: 7955:rpl5b
uniprot id: Q6IQB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

7955:phf1
gene id: 7955:phf1
uniprot id: A0A8M1RE33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

7955:hmga1a
gene id: 7955:hmga1a
uniprot id: E9QD31
uniprot id: Q6NV11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

7955:LOC101885345
gene id: 7955:LOC101885345
uniprot id: A0A8M9PMG3
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

7955:si:dkey-219c10.4
gene id: 7955:si:dkey-219c10.4
uniprot id: A0A8M6Z8P7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

7955:dhrs7
gene id: 7955:dhrs7
uniprot id: Q0P3U1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:atp1b2a
gene id: 7955:atp1b2a
uniprot id: A0A8M9PKU7
uniprot id: Q9DGL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

7955:blk
gene id: 7955:blk
uniprot id: A0A8M6YUU4
uniprot id: Q5TYU7
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

7955:slc9a3.1
gene id: 7955:slc9a3.1
uniprot id: A9XPA1
uniprot id: B7ZVJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Membrane
messages: Recycling endosome membrane

7955:slc25a38b
gene id: 7955:slc25a38b
uniprot id: A0A8M9Q680
uniprot id: P0CAT2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: At 24 hours post-fertilization, expressed predominantly in posterior blood island, posterior cardinal vein and circulating blood. At 34 hours post-fertilization, becomes restricted to posterior blood island and circulating blood.
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Fishes lacking both slc25a38a and slc25a38b display anemia.
messages: May play a role as pro-apoptotic protein that induces caspase-dependent apoptosis.
messages: Membrane
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis.
messages: Mitochondrion inner membrane

7955:slc15a2
gene id: 7955:slc15a2
uniprot id: B0S6T2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Cell membrane
messages: Detected at 1 to 7 days post-fertilization (dpf). Expressed in the forebrain and midbrain at 1 dpf, where it localizes to the ependymal cell layer of the dicephalic ventricle and midbrain ventricle. Expressed in the developing otic vesicle at 2-7 dpf, where it shows particularly strong expression in the epithelium of the semicircular canal projections.
messages: Expressed in kidney, brain and gut. Also expressed weakly in eye, gill and skeletal muscle.
messages: Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:16317081). Transports neutral and anionic dipeptides with a proton to peptide stoichiometry of 2:1 or 3:1 (By similarity).
messages: phagosome membrane

7955:amy2a
gene id: 7955:amy2a
uniprot id: Q6P5J0
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

7955:ddr1
gene id: 7955:ddr1
uniprot id: A0A2R8RJX9
uniprot id: A0A8M3AI21
uniprot id: E7F3X9
names: Subcellular Location Annotation
messages: Membrane

7955:taar20l
gene id: 7955:taar20l
uniprot id: F1RB61
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:si:ch211-207n2.8
gene id: 7955:si:ch211-207n2.8
uniprot id: A0A8N7T6R5
names: Similarity
messages: Belongs to the VPS10-related sortilin family. SORCS subfamily.

7955:he1b
gene id: 7955:he1b
uniprot id: Q1LW01
names: Cofactor
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Detected in embryos just before the bud stage, in an oval patch in the polster (anterior prechordal plate) (PubMed:9108332). At the 3-somite stage, found in a horseshoe-shaped cluster of cells surrounding the head primordium (PubMed:9108332). From 24 hours post-fertilization (hpf) onwards, expressed in a belt-like shape on the anterior surface of the yolk sac (PubMed:9108332, PubMed:19021768). Little or no expression detected after hatching (PubMed:9108332, PubMed:19021768).
messages: Expressed in cells of the hatching gland.
messages: Metalloendopeptidase which participates in the breakdown of the egg envelope at the time of hatching. Cleaves the N-terminal regions of the zona pellucia glycoproteins ZP2 and ZP3, where it specifically recognizes the peptide sequences TVQQS-|-DYLIK (major site) and KLMLK-|-APEPF (minor site).
messages: Secreted

7955:asxl1
gene id: 7955:asxl1
uniprot id: A0A8M2B9F5
uniprot id: A0A8M9PE54
uniprot id: A0A8M9PX23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Asx family.
messages: Nucleus

7955:tdrd5
gene id: 7955:tdrd5
uniprot id: A0A8M9PDW1
uniprot id: Q1L981
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDRD5 family.
messages: Cytoplasm
messages: Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity).

7955:LOC101885179
gene id: 7955:LOC101885179
uniprot id: M1ZML1
names: Similarity
messages: Belongs to the nanos family.

7955:chd6
gene id: 7955:chd6
uniprot id: A0A8M3ATN8
uniprot id: A0A8M3BAM2
uniprot id: A0A8M9PNA9
uniprot id: A0A8N7T870
uniprot id: X1WCW5
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

7955:hkdc1
gene id: 7955:hkdc1
uniprot id: B8A5H6
names: Similarity
messages: Belongs to the hexokinase family.

7955:snupn
gene id: 7955:snupn
uniprot id: A0A8M9P6D1
uniprot id: Q6P5J9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snurportin family.
messages: Cytoplasm
messages: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
messages: Nucleus

7955:mrps7
gene id: 7955:mrps7
uniprot id: Q498Z6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

7955:tlr4bb
gene id: 7955:tlr4bb
uniprot id: B8A691
uniprot id: Q6TS41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

7955:smcr8b
gene id: 7955:smcr8b
uniprot id: Q6PUR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMCR8 family.
messages: Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity.
messages: Component of the C9orf72-SMCR8 complex. The C9orf72-SMCR8 complex associates with the ATG1/ULK1 kinase complex.
messages: Cytoplasm
messages: Nucleus

7955:gdpd5b
gene id: 7955:gdpd5b
uniprot id: A0A2R8Q763
uniprot id: A0A8M2B4R1
uniprot id: A0A8M9PCF6
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

7955:hbae1
gene id: 7955:hbae1
uniprot id: Q7ZT21
names: Similarity
messages: Belongs to the globin family.

7955:slc22a2
gene id: 7955:slc22a2
uniprot id: Q7T2C0
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

7955:galnt13
gene id: 7955:galnt13
uniprot id: A0A286Y879
uniprot id: A0A8M2BFD9
uniprot id: A0A8M3AVR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

7955:nppb
gene id: 7955:nppb
uniprot id: F1R8L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

7955:prdm8b
gene id: 7955:prdm8b
uniprot id: A2BG51
names: Subcellular Location Annotation
messages: Nucleus

7955:si:dkey-23a13.1
gene id: 7955:si:dkey-23a13.1
uniprot id: F1QAU0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:thumpd2
gene id: 7955:thumpd2
uniprot id: X1WET5
names: Similarity
messages: Belongs to the methyltransferase superfamily.

7955:ptgdsb.2
gene id: 7955:ptgdsb.2
uniprot id: Q0P4C2
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

7955:zgc:66447
gene id: 7955:zgc:66447
uniprot id: A0A0R4I9B0
uniprot id: A0A8M9QGA9
uniprot id: Q7SXC6
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

7955:chia.6
gene id: 7955:chia.6
uniprot id: F1QJL0
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

7955:zgc:123035
gene id: 7955:zgc:123035
uniprot id: Q3B7E8
uniprot id: Q5GH42
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:dnah1
gene id: 7955:dnah1
uniprot id: A0A8M3AXS6
names: Similarity
messages: Belongs to the dynein heavy chain family.

7955:rbfox2
gene id: 7955:rbfox2
uniprot id: A0A8M9PM01
uniprot id: A0A8M9PZL7
uniprot id: A0A8M9Q615
uniprot id: A0A8M9QA95
uniprot id: A0A8M9QFB1
uniprot id: Q6NV06
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events.

7955:kpnb1
gene id: 7955:kpnb1
uniprot id: A0A0R4IMZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the importin beta family. Importin beta-1 subfamily.
messages: Cytoplasm

7955:si:ch73-236j9.2
gene id: 7955:si:ch73-236j9.2
uniprot id: A0A8M9QAA2
names: Subcellular Location Annotation
messages: Membrane

7955:cdk4
gene id: 7955:cdk4
uniprot id: Q08C29
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:prkar1aa
gene id: 7955:prkar1aa
uniprot id: Q5I0F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

7955:crcp
gene id: 7955:crcp
uniprot id: A0A8M1NAV1
uniprot id: A0A8M9PIF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Nucleus

7955:fdft1
gene id: 7955:fdft1
uniprot id: A0A0R4IVV5
uniprot id: A0A8M9PPK1
names: Function
names: Similarity
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.

7955:zgc:154164
gene id: 7955:zgc:154164
uniprot id: Q0D272
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:fynrk
gene id: 7955:fynrk
uniprot id: A0A8M9PC12
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

7955:emc2
gene id: 7955:emc2
uniprot id: Q6TGY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.

7955:mturn
gene id: 7955:mturn
uniprot id: P0C8M4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTURN family.
messages: Cytoplasm
messages: Expressed in embryo throughout the early nervous system. Strongly expressed in differentiating neurons in the brain, spinal cord and retina. Not detected in the lens at any developmental stage tested.
messages: May be involved in early neuronal development (By similarity). May play a role in promoting megakaryocyte differentiation (By similarity).

7955:amot
gene id: 7955:amot
uniprot id: A0A8M2BL72
uniprot id: E7F8Q6
names: Similarity
messages: Belongs to the angiomotin family.

7955:LOC569340
gene id: 7955:LOC569340
uniprot id: A0A8M1RP32
uniprot id: A0A8M3AL98
uniprot id: A0A8M3ASY8
uniprot id: A0A8M9P2U2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: interphotoreceptor matrix

7955:zgc:91910
gene id: 7955:zgc:91910
uniprot id: Q6AZC6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7955:LOC100007467
gene id: 7955:LOC100007467
uniprot id: A0A8M6YZ46
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:si:ch211-137i24.10
gene id: 7955:si:ch211-137i24.10
uniprot id: A2BEN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

7955:LOC108191519
gene id: 7955:LOC108191519
uniprot id: A0A8M6Z1H6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:oaz1b
gene id: 7955:oaz1b
uniprot id: A0A0R4IVI9
uniprot id: Q9YI97
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the ODC antizyme family.
messages: Expressed in both embryos and adults.
messages: Expressed ubiquitously in 24 hours embryos, with highest levels in telencephalon, lens, retina, cerebellum and hindbrain primordia.
messages: Interacts with ODC1 and thereby sterically blocks ODC homodimerization.
messages: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity.

7955:upk1a
gene id: 7955:upk1a
uniprot id: Q1RLU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7955:pou3f1
gene id: 7955:pou3f1
uniprot id: Q90482
names: Developmental Stage
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Expression starts between 10 and 12 hours post fecondation and is highest between 2 and 3 days after fertilization.
messages: Nucleus
messages: Predominantly expressed in the embryonic and adult central nervous system.
messages: Transcription factor that may play important roles in patterning the embryonic brain. Could directly respond to the reception of the sonic hedgehog (shh) signal.

7955:pomgnt1
gene id: 7955:pomgnt1
uniprot id: F1QNB2
uniprot id: Q0PIP4
uniprot id: Q4V907
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.
messages: The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.
messages: The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein.

7955:si:dkey-94f20.4
gene id: 7955:si:dkey-94f20.4
uniprot id: A0A8M9PWP6
uniprot id: A0A8M9Q8R4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

7955:mmp30
gene id: 7955:mmp30
uniprot id: Q1RM69
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

7955:best2
gene id: 7955:best2
uniprot id: A0A8N7TBM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

7955:ncaph2
gene id: 7955:ncaph2
uniprot id: Q5RH01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CND2 H2 (condensin-2 subunit 2) family.
messages: Component of the condensin-2 complex, which contains the smc2 and smc4 heterodimer, and three non SMC subunits, ncapg2, ncaph2 and ncapd3 that probably regulate the complex.
messages: Nucleus
messages: Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture.

7955:LOC100333855
gene id: 7955:LOC100333855
uniprot id: E7EXK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Membrane

7955:arf6a
gene id: 7955:arf6a
uniprot id: Q6P2U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cell membrane
messages: Cleavage furrow
messages: Endosome membrane
messages: Midbody ring
messages: Recycling endosome membrane
messages: filopodium membrane
messages: ruffle

7955:dzip1
gene id: 7955:dzip1
uniprot id: A0A8M2BCZ0
uniprot id: A0A8M2BD71
uniprot id: A0A8M3AT21
uniprot id: F1QHQ9
uniprot id: F1QNW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DZIP C2H2-type zinc-finger protein family.
messages: cilium basal body

7955:mboat7
gene id: 7955:mboat7
uniprot id: F1Q9V3
uniprot id: Q7SZQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA to a lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) leading to the production of a phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. Prefers arachidonoyl-CoA as the acyl donor, thus contributing to the regulation of free levels arachidonic acid in cell.
messages: Belongs to the membrane-bound acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:stmn4l
gene id: 7955:stmn4l
uniprot id: E9QJN2
uniprot id: Q6DGV2
names: Similarity
messages: Belongs to the stathmin family.

7955:pik3r1
gene id: 7955:pik3r1
uniprot id: A0A8M2BCX6
uniprot id: A0A8M2BCY4
uniprot id: B0S6V6
uniprot id: B0S6V7
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

7955:or106-10
gene id: 7955:or106-10
uniprot id: A0A8M6Z8Z3
uniprot id: Q2PRK7
names: Subcellular Location Annotation
messages: Membrane

7955:LOC567149
gene id: 7955:LOC567149
uniprot id: A0A140LGT9
uniprot id: A0A8M6Z274
uniprot id: A0A8M9QBM9
names: Similarity
messages: Belongs to the LECT2/MIM-1 family.

7955:pacsin1b
gene id: 7955:pacsin1b
uniprot id: B2GTA5
uniprot id: Q4V920
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in cellular transport processes by recruiting dynamins to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with cobl, and by recruiting cobl to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Required for normal embryonic development, including normal development of laterality, normal body size and shape, as well as normal brain and heart development. Required for normal development of stereocilia and kinocilia in sensory hair cells of neuromasts in the posterior lateral line organ, and thus also for balance keeping and normal swimming behavior.
messages: Cell membrane
messages: Cell projection
messages: Cytoplasm
messages: Cytoplasmic vesicle membrane
messages: Highly expressed throughout embryogenesis, from fertilization to hatching. Detected in embryonic neuronal tissues, including forebrain, hindbrain, spinal cord and retina.
messages: Interacts with cobl.
messages: Membrane
messages: Synapse
messages: The F-BAR domain mediates membrane-binding and membrane tubulation.
messages: cytosol
messages: ruffle membrane
messages: synaptosome

7955:jmjd1cb
gene id: 7955:jmjd1cb
uniprot id: A0A8M2B2R0
uniprot id: A0A8M2B2Y5
uniprot id: A0A8M3AY42
uniprot id: A0A8M3AY68
uniprot id: A0A8M3B4G8
uniprot id: A0A8M3B798
uniprot id: A0A8M3BE19
uniprot id: A0A8M6Z3J7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM2 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
messages: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
messages: Nucleus
messages: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.

7955:spo11
gene id: 7955:spo11
uniprot id: Q6P0S6
names: Similarity
messages: Belongs to the TOP6A family.

7955:si:ch1073-365p7.2
gene id: 7955:si:ch1073-365p7.2
uniprot id: A0A140LFW6
uniprot id: A0A8M9QID3
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:or113-1
gene id: 7955:or113-1
uniprot id: Q2PRE5
names: Subcellular Location Annotation
messages: Membrane

7955:rundc3ab
gene id: 7955:rundc3ab
uniprot id: A7YDW0
uniprot id: B2GT93
names: Developmental Stage
names: Similarity
messages: Belongs to the RUNDC3 family.
messages: Expressed both maternally and zygotically during embryonic development.

7955:id1
gene id: 7955:id1
uniprot id: Q6IQW5
names: Subcellular Location Annotation
messages: Nucleus

7955:taar12e
gene id: 7955:taar12e
uniprot id: Q5QNN9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:chd1
gene id: 7955:chd1
uniprot id: A0A0R4IAE4
uniprot id: A0A0R4IC05
uniprot id: A0A8M3B604
names: Subcellular Location Annotation
messages: Nucleus

7955:zgc:112437
gene id: 7955:zgc:112437
uniprot id: Q561T6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

7955:cpdb
gene id: 7955:cpdb
uniprot id: E7FFQ7
names: Similarity
messages: Belongs to the peptidase M14 family.

7955:si:ch211-74f19.2
gene id: 7955:si:ch211-74f19.2
uniprot id: F1RES5
names: Similarity
messages: Belongs to the ADISSP family.

7955:si:cabz01093077.1
gene id: 7955:si:cabz01093077.1
uniprot id: A0A8M2BKR3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:mst1
gene id: 7955:mst1
uniprot id: Q90ZN6
names: Caution
names: Similarity
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC100334559
gene id: 7955:LOC100334559
uniprot id: A7MCA7
uniprot id: Q5BJA5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-111 promotes monoubiquitination of Lys-119. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-119 by the BRE1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: Phosphorylated during apoptosis; which facilitates apoptotic chromatin condensation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:sgk2a
gene id: 7955:sgk2a
uniprot id: A8WG09
uniprot id: F1QBK0
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:LOC100536673
gene id: 7955:LOC100536673
uniprot id: E7FDN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 16 (GT16) protein family.
messages: Golgi apparatus membrane
messages: Membrane

7955:fcho2
gene id: 7955:fcho2
uniprot id: A0A8M2BJ82
uniprot id: A0A8M3ASB7
uniprot id: A0A8M3AZM0
uniprot id: A0A8M3B2H5
uniprot id: A0A8M3B9M8
uniprot id: A0A8M9PK46
uniprot id: A0A8M9PXK6
uniprot id: A0A8M9Q3B6
uniprot id: A0A8M9Q8L9
uniprot id: A0A8M9QDY0
uniprot id: Q502I9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FCHO family.
messages: Homodimer.
messages: May function in an early step of clathrin-mediated endocytosis.
messages: clathrin-coated pit

7955:arl6ip5b
gene id: 7955:arl6ip5b
uniprot id: Q6DGQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

7955:ccr10
gene id: 7955:ccr10
uniprot id: Q6DG12
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:lrrfip1b
gene id: 7955:lrrfip1b
uniprot id: A0A8M2BFZ6
uniprot id: A0A8M2BG01
uniprot id: A0A8M2BG03
uniprot id: A0A8M2BG13
uniprot id: A0A8M2BGK9
uniprot id: A0A8M3AT95
uniprot id: A0A8M3AT96
uniprot id: A0A8M3B0C1
uniprot id: A0A8M3B3B5
uniprot id: A0A8M3BAA5
uniprot id: A0A8M9PMM5
uniprot id: A0A8M9Q0A6
uniprot id: A0A8M9Q6M9
uniprot id: A0A8M9QAU2
uniprot id: A0A8M9QFV4
names: Similarity
messages: Belongs to the LRRFIP family.

7955:abcb9
gene id: 7955:abcb9
uniprot id: A0A8M2BJB8
uniprot id: A3KGZ4
names: Subcellular Location Annotation
messages: Membrane

7955:ccng1
gene id: 7955:ccng1
uniprot id: A0A8M9QP15
uniprot id: Q7ZTX1
names: Similarity
messages: Belongs to the cyclin family.

7955:erc2
gene id: 7955:erc2
uniprot id: A0A8M3AXU3
uniprot id: A0A8M3AXX0
uniprot id: A0A8M3BDV4
uniprot id: A0A8M9QA98
uniprot id: A0A8M9QJB1
names: Subcellular Location Annotation
messages: Cytoplasm

7955:slc48a1b
gene id: 7955:slc48a1b
uniprot id: B7ZVN2
uniprot id: Q7T3B2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the HRG family.
messages: Endosome membrane
messages: Expressed throughout the embryo, including the central nervous system.
messages: Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment. In macrophages, is the heme transporter for heme-iron recycling (PubMed:18418376). Essential for macrophage iron homeostasis, transports heme from the phagolysosome to the cytoplasm during erythrophagocytosis (EP) (PubMed:23395172).
messages: Lysosome membrane
messages: Membrane
messages: Mutant embryos show severe erythropoietic defect.
messages: phagosome membrane

7955:smc1al
gene id: 7955:smc1al
uniprot id: Q6DRM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

7955:prlh2r
gene id: 7955:prlh2r
uniprot id: B1NYI2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:cacna2d3a
gene id: 7955:cacna2d3a
uniprot id: A0A8M3BC64
uniprot id: A0A8M9PRL7
uniprot id: A0A8M9Q438
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

7955:LOC110438406
gene id: 7955:LOC110438406
uniprot id: A0A8M9PVR0
names: Subcellular Location Annotation
messages: Nucleus

7955:tmem55a
gene id: 7955:tmem55a
uniprot id: Q1LWC3
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

7955:bcat1
gene id: 7955:bcat1
uniprot id: A0A8M2BBX5
uniprot id: A0A8M3AYQ7
uniprot id: Q6PC10
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

7955:sox4b
gene id: 7955:sox4b
uniprot id: Q6P2A2
names: Subcellular Location Annotation
messages: Nucleus

7955:brd1b
gene id: 7955:brd1b
uniprot id: A0A8M2BA66
names: Subcellular Location Annotation
messages: Nucleus

7955:nkx2.2b
gene id: 7955:nkx2.2b
uniprot id: Q5BJA8
names: Subcellular Location Annotation
messages: Nucleus

7955:btaf1
gene id: 7955:btaf1
uniprot id: A0A8M2BGW0
names: Subcellular Location Annotation
messages: Nucleus

7955:senp3b
gene id: 7955:senp3b
uniprot id: A4IFY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

7955:LOC108191558
gene id: 7955:LOC108191558
uniprot id: H0WET4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:penkb
gene id: 7955:penkb
uniprot id: Q7T3L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Secreted

7955:rundc3aa
gene id: 7955:rundc3aa
uniprot id: F1QCE8
names: Similarity
messages: Belongs to the RUNDC3 family.

7955:fam69c
gene id: 7955:fam69c
uniprot id: Q6NW49
names: Similarity
messages: Belongs to the DIPK family.

7955:ndufs1
gene id: 7955:ndufs1
uniprot id: Q5RKM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 75 kDa subunit family.
messages: Mitochondrion inner membrane

7955:mcoln3a
gene id: 7955:mcoln3a
uniprot id: A0A8M9P7U6
uniprot id: E7FE44
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

7955:pgpep1l
gene id: 7955:pgpep1l
uniprot id: A0A8M9PFT5
names: Similarity
messages: Belongs to the peptidase C15 family.

7955:tjp3
gene id: 7955:tjp3
uniprot id: A0A8M2BHQ8
names: Similarity
messages: Belongs to the MAGUK family.

7955:si:dkey-88j15.3
gene id: 7955:si:dkey-88j15.3
uniprot id: A0A140LGH1
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:LOC110439348
gene id: 7955:LOC110439348
uniprot id: A0A8M9PHM1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:tmco3
gene id: 7955:tmco3
uniprot id: A0A8M9PJF7
names: Subcellular Location Annotation
messages: Membrane

7955:LOC100329748
gene id: 7955:LOC100329748
uniprot id: A0A8M9PEC3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:pdcd5
gene id: 7955:pdcd5
uniprot id: Q7ZUZ4
names: Similarity
messages: Belongs to the PDCD5 family.

7955:babam2
gene id: 7955:babam2
uniprot id: A0A8M9P8W4
uniprot id: Q568D5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM2 family.
messages: Component of the ARISC complex, at least composed of uimc1/rap80, abraxas1, brcc3/brcc36, BABAM2 and babam1/nba1. Component of the BRCA1-A complex, at least composed of bard1, uimc1/rap80, abraxas1, brcc3/brcc36, BABAM2 and babam1/nba1. In the BRCA1-A complex, interacts directly with abraxas1, brcc3/brcc36 and babam1/nba1. Binds polyubiquitin. Component of the BRISC complex, at least composed of abraxas2, brcc3/brcc36, babam2 and babam1/nba1 (PubMed:26344097).
messages: Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.
messages: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites. The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between babam1/nba1 and the rest of the complex, thereby being required for the complex integrity. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:26344097). Within the BRISC complex, acts as an adapter that bridges the interaction between babam1/nba1 and the rest of the complex, thereby being required for the complex integrity. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating numa1. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
messages: Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
messages: Cytoplasm
messages: May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
messages: Nucleus
messages: There is no annotated ortholog of the vertebrate gene BRCA1 in the current zebrafish genome (PubMed:23594743). Therefore, mentions of brca1 in relevant curated zebrafish entries have been removed. However some complexes, conserved widely across species, have BRCA1 in their name and so have been left unchanged.

7955:cpt1cb
gene id: 7955:cpt1cb
uniprot id: A0A8M9PFB6
uniprot id: A0A8M9PYA7
uniprot id: E7EYD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

7955:dus4l
gene id: 7955:dus4l
uniprot id: Q5RIX6
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

7955:yod1
gene id: 7955:yod1
uniprot id: Q567B1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin.

7955:LOC100332745
gene id: 7955:LOC100332745
uniprot id: A0A8M9PIP8
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:zgc:86839
gene id: 7955:zgc:86839
uniprot id: Q6IQC3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

7955:kcnma1b
gene id: 7955:kcnma1b
uniprot id: A0A8M9PXE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
messages: Membrane

7955:slc25a6
gene id: 7955:slc25a6
uniprot id: B0S730
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

7955:olfcg8
gene id: 7955:olfcg8
uniprot id: A0A8M3AKH6
uniprot id: A0A8M3B2Z8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:rpl23
gene id: 7955:rpl23
uniprot id: Q6PC14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

7955:cbsb
gene id: 7955:cbsb
uniprot id: Q5EI65
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

7955:llgl1
gene id: 7955:llgl1
uniprot id: A0A8M2BBF6
uniprot id: A0A8M9PXW4
uniprot id: E7FD67
uniprot id: I0BWE2
names: Similarity
messages: Belongs to the WD repeat L(2)GL family.

7955:dpysl3
gene id: 7955:dpysl3
uniprot id: Q52PJ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: At 16 hours post-fertilization, expressed in the presumptive nucleus of the medial longitudinal fascicle, the presumptive trigeminal ganglion and the spinal cord. Expression in the spinal cord is strongest towards the rostral, more mature, spinal cord, and weaker towards the caudal spinal cord. At 24 hours post-fertilization, expressed in the olfactory placode, in the telencephalon and diencephalon but not in the proliferating ventricular zone. Expressed in the epiphysis, the nucleus of the medial longitudinal fascicle and in the area close to the nucleus of the posterior commissure. Expression in the hindbrain is restricted to reticulospinal neurons. In the cranial ganglia, expressed in the trigeminal, acoustic/anterior lateral line and posterior lateral line ganglion. In the spinal cord, expressed in the large dorsally-located Rohon-Beard neurons.
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Cytoplasm
messages: Homotetramer, and heterotetramer.
messages: Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.
messages: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).
messages: growth cone

7955:zc2hc1a
gene id: 7955:zc2hc1a
uniprot id: Q7SXT7
names: Similarity
messages: Belongs to the ZC2HC1 family.

7955:st8sia5
gene id: 7955:st8sia5
uniprot id: A0A8M2B7X1
uniprot id: Q0P7H3
uniprot id: Q0P7H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

7955:stx2a
gene id: 7955:stx2a
uniprot id: E9QCC0
uniprot id: Q6DEJ2
names: Similarity
messages: Belongs to the syntaxin family.

7955:prokr1b
gene id: 7955:prokr1b
uniprot id: D3TZW2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:or109-7
gene id: 7955:or109-7
uniprot id: Q2PRJ7
names: Subcellular Location Annotation
messages: Membrane

7955:LOC110437854
gene id: 7955:LOC110437854
uniprot id: F8W2T9
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.
messages: Belongs to the MoaD family. MOCS2A subfamily.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
messages: This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2B).
messages: cytosol

7955:slc6a1b
gene id: 7955:slc6a1b
uniprot id: Q5U3E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:LOC108183287
gene id: 7955:LOC108183287
uniprot id: A0A8M9Q651
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:nudt4b
gene id: 7955:nudt4b
uniprot id: Q66JN9
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

7955:pcdh2aa3
gene id: 7955:pcdh2aa3
uniprot id: Q60H66
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

7955:ccdc47
gene id: 7955:ccdc47
uniprot id: Q66I12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC47 family.
messages: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions.
messages: Component of the multi-pass translocon (MPT) complex.
messages: Endoplasmic reticulum membrane
messages: Rough endoplasmic reticulum membrane

7955:wscd2
gene id: 7955:wscd2
uniprot id: A0A8M2BCI1
uniprot id: A2BGL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WSCD family.
messages: Golgi apparatus membrane
messages: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.

7955:LOC569262
gene id: 7955:LOC569262
uniprot id: A0A8M2BL66
uniprot id: A0A8M6Z3G5
names: Similarity
messages: Belongs to the OXR1 family.

7955:pcyt1bb
gene id: 7955:pcyt1bb
uniprot id: A0A0R4IKK6
uniprot id: Q32LS9
names: Function
names: Similarity
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.

7955:zgc:66014
gene id: 7955:zgc:66014
uniprot id: Q6P6Y1
names: Function
names: Subcellular Location Annotation
messages: May regulate intracellular cholesterol transport.
messages: Recycling endosome
messages: trans-Golgi network

7955:rrp7a
gene id: 7955:rrp7a
uniprot id: Q568T7
names: Similarity
messages: Belongs to the RRP7 family.

7955:gulp1a
gene id: 7955:gulp1a
uniprot id: Q32PV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ced-6 family.
messages: Cytoplasm
messages: May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. May play a role in the internalization and endosomal trafficking of various lrp1 ligands (By similarity).

7955:si:ch211-286o17.1
gene id: 7955:si:ch211-286o17.1
uniprot id: A0A0R4IT40
names: Subcellular Location Annotation
messages: Membrane

7955:traf1
gene id: 7955:traf1
uniprot id: B0UXK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

7955:LOC100331359
gene id: 7955:LOC100331359
uniprot id: A0A8M9Q2S6
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:rpl30
gene id: 7955:rpl30
uniprot id: Q7ZUG6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

7955:rrp12
gene id: 7955:rrp12
uniprot id: Q4KMF4
names: Similarity
messages: Belongs to the RRP12 family.

7955:psenen
gene id: 7955:psenen
uniprot id: Q8JHF0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 3D-structure analysis of the human homolog indicates that the membrane topology differs from the predictions. Contrary to predictions, the N-terminus contains two short helices that dip into the membrane, but do not cross it. The C-terminus contains the single transmembrane helix. This gives rise to a topology where the N-terminus is cytoplasmic and the C-terminus is lumenal.
messages: Belongs to the PEN-2 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins.
messages: Golgi stack membrane
messages: Membrane
messages: The functional gamma-secretase complex is composed of at least four polypeptides: a presenilin homodimer (psen1 or psen2), nicastrin (ncstn), aph1 (aph1a or aph1b) and psenen.

7955:zgc:63587
gene id: 7955:zgc:63587
uniprot id: A0A8M2BJN0
uniprot id: Q7SY26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Midbody
messages: cilium membrane
messages: spindle

7955:ubap2l
gene id: 7955:ubap2l
uniprot id: A0A8M2B5X1
uniprot id: A0A8M9P1N2
uniprot id: A0A8M9PAR6
uniprot id: A0A8M9PN11
uniprot id: A0A8M9PR82
uniprot id: Q1L8T3
names: Subcellular Location Annotation
messages: Cytoplasm

7955:dusp13a
gene id: 7955:dusp13a
uniprot id: A8WGA2
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of AMPK and MAPK1/2 signaling pathways.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

7955:tmprss9
gene id: 7955:tmprss9
uniprot id: F1QKM9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:zgc:154064
gene id: 7955:zgc:154064
uniprot id: A2VD26
names: Similarity
messages: Belongs to the SPATS2 family.

7955:tfa
gene id: 7955:tfa
uniprot id: B8JL43
uniprot id: Q6P3G0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferrin family.
messages: Monomer.
messages: Secreted
messages: Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate.

7955:slc18a2
gene id: 7955:slc18a2
uniprot id: A0A8M1P3E9
uniprot id: Q5CZP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Vesicular transporter family.
messages: Membrane

7955:cd164l2
gene id: 7955:cd164l2
uniprot id: A0A8M9PGR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

7955:nav3
gene id: 7955:nav3
uniprot id: A0A8M3ARI4
uniprot id: A0A8M3ARS0
uniprot id: A0A8M3B919
uniprot id: A0A8M6YX31
uniprot id: A0A8M9PHG5
uniprot id: A0A8M9PHG9
uniprot id: A0A8M9PHH5
uniprot id: A0A8M9PUP3
uniprot id: A0A8M9PUQ1
uniprot id: A0A8M9PUQ7
uniprot id: A0A8M9Q0P5
uniprot id: A0A8M9Q0Q3
uniprot id: A0A8M9Q0Q8
uniprot id: A0A8M9Q610
uniprot id: A0A8M9Q614
uniprot id: A0A8M9Q620
uniprot id: A0A8M9QBF3
uniprot id: A0A8M9QBF8
uniprot id: A0A8M9QBG6
uniprot id: A0A8M9QBH1
uniprot id: Q5TZ18
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nav/unc-53 family.
messages: Expressed in brain and somites, and slight expression in cardiac primordium, at 18 hours post-fertilization (hpf) (PubMed:35039994). Expression is initiated at 22 hpf in the gut endoderm in an area known to be the origin of hepatic precursor cells and at 40 hpf, expands to the newly formed liver bud (PubMed:21471154). Expression is reduced after termination of primary liver formation (PubMed:21471154). Expressed in the brain, heart, and somites at 24 hpf (PubMed:35039994). Expression in somites becomes weaker, and is rarely detected from 48 hpf onwards (PubMed:35039994). Expressed in the cardiac region from 24 to 48 hpf (PubMed:35039994). At 48 hpf, expression is regionalized to the brain and heart (PubMed:21471154). At 96 hpf, almost no expression in heart, and expression is found to be accumulated in other tissues, such as the gill arch, swim bladder, and intestine (PubMed:35039994).
messages: Golgi apparatus
messages: Interacts with F-actin.
messages: Involved in liver and heart organogenesis during embryo development (PubMed:21471154, PubMed:35039994). Plays a role in the migration of hepatoblasts from the intestinal endoderm during liver organogenesis; possibly by modulating actin polymerization during hepatoblast outgrowth (PubMed:21471154). May be involved in neuron regeneration (By similarity).
messages: Nucleus outer membrane
messages: Severe deficiency in cardiac morphology and structure and 70% enbryonic lethality within 24 hpf (PubMed:35039994). Morpholino-mediated knockdown impairs the migration of hepatoblasts out from the gut endoderm, blocks liver bud formation, and results in a reduced liver size (PubMed:21471154). Also impairs development of pancreas and swim bladder (PubMed:21471154).
messages: filopodium
messages: lamellipodium

7955:gpn1
gene id: 7955:gpn1
uniprot id: Q6DC83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II.
messages: Cytoplasm
messages: Nucleus
messages: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.

7955:or128-5
gene id: 7955:or128-5
uniprot id: Q2PRG0
names: Subcellular Location Annotation
messages: Membrane

7955:ppp6c
gene id: 7955:ppp6c
uniprot id: Q7ZUS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

7955:sec13
gene id: 7955:sec13
uniprot id: Q7T2E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Lysosome membrane

7955:fam188a
gene id: 7955:fam188a
uniprot id: A0AUR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
messages: Nucleus

7955:LOC566136
gene id: 7955:LOC566136
uniprot id: A0A8M3AZL0
uniprot id: A0A8M3B8F7
uniprot id: A0A8M6Z480
uniprot id: A0A8M9QGK8
names: Similarity
messages: Belongs to the MAP7 family.

7955:ptgir
gene id: 7955:ptgir
uniprot id: E7FE45
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:hiat1a
gene id: 7955:hiat1a
uniprot id: Q6PGV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

7955:map7d1b
gene id: 7955:map7d1b
uniprot id: A0A8M2BL12
uniprot id: A0A8M2BL29
uniprot id: A0A8M2BL37
uniprot id: A0A8M3AJX7
uniprot id: A8WG76
names: Similarity
messages: Belongs to the MAP7 family.

7955:tbc1d23
gene id: 7955:tbc1d23
uniprot id: A0A8M2BD99
uniprot id: Q7SXV1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Detected as early as 1 hour post-fertilization (hpf). Primarily localized in the head at 48 hpf.
messages: Morpholino knockdown of the protein causes reduced brain and eye size and curved tails at 48 hpf.
messages: Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (By similarity). Plays a role in brain development (PubMed:28823706). May act as a general inhibitor of innate immunity signaling (By similarity).
messages: trans-Golgi network

7955:rnf41
gene id: 7955:rnf41
uniprot id: Q7ZW16
names: Function
messages: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins.

7955:hddc3
gene id: 7955:hddc3
uniprot id: Q568P1
names: Function
names: Similarity
messages: Belongs to the MESH1 family.
messages: ppGpp hydrolyzing enzyme involved in starvation response.

7955:zgc:113363
gene id: 7955:zgc:113363
uniprot id: A0A8M9Q9U4
uniprot id: B0V1R0
names: Similarity
messages: Belongs to the MDFI family.

7955:best1
gene id: 7955:best1
uniprot id: A0A2R8Q9T0
uniprot id: A0A8M3ANU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

7955:LOC108190994
gene id: 7955:LOC108190994
uniprot id: A0A8M6Z0Q9
names: Subcellular Location Annotation
messages: Nucleus

7955:znf592
gene id: 7955:znf592
uniprot id: A0A8M2B5T2
uniprot id: A0A8M6YU69
uniprot id: Q1LVK7
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

7955:mogs
gene id: 7955:mogs
uniprot id: A1L1S8
uniprot id: B8A4C4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
messages: Endoplasmic reticulum membrane

7955:pole2
gene id: 7955:pole2
uniprot id: Q8JHG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase epsilon subunit B family.
messages: Nucleus
messages: Participates in DNA repair and in chromosomal DNA replication.

7955:shisa9a
gene id: 7955:shisa9a
uniprot id: Q5BLC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shisa family. SHISA9 subfamily.
messages: Component of some AMPA receptors (ionotropic glutamate receptors) complex.
messages: Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity).
messages: Synapse
messages: dendritic spine membrane

7955:cdk20
gene id: 7955:cdk20
uniprot id: A0A8M3B1S0
uniprot id: A8WIP6
uniprot id: B2GQ42
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Cytoplasm
messages: Fish lacking cdk20 are viable during embryogenesis and early larval stages, but exhibit curvature of the body axis and curled cilia in distal kidney tubules.
messages: Involved in cell growth. Activates cdk2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity). Required for high-level Shh responses in the developing neural tube. Together with tbc1d32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing gli2 to be properly activated in response to SHH signaling.
messages: Monomer. Interacts with tbc1d32.
messages: Nucleus
messages: cilium

7955:nrn1la
gene id: 7955:nrn1la
uniprot id: F1QK42
names: Similarity
messages: Belongs to the neuritin family.

7955:tomm5
gene id: 7955:tomm5
uniprot id: F6NZ76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom5 family.
messages: Membrane
messages: Mitochondrion outer membrane

7955:cfap45
gene id: 7955:cfap45
uniprot id: A0A8M1NCB7
uniprot id: A2RV04
names: Similarity
messages: Belongs to the CFAP45 family.

7955:rhpn2
gene id: 7955:rhpn2
uniprot id: A0A8M2BG90
uniprot id: Q6TNR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RHPN family.
messages: Binds specifically to GTP-Rho.
messages: Cytoplasm
messages: Interacts with RhoA.

7955:wnt10a
gene id: 7955:wnt10a
uniprot id: B0V1G8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

7955:si:ch211-195d17.2
gene id: 7955:si:ch211-195d17.2
uniprot id: A0A8M1N779
uniprot id: Q5TZC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

7955:kcnb1
gene id: 7955:kcnb1
uniprot id: A0A2R8Q685
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.
messages: Lateral cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: axon
messages: dendrite
messages: sarcolemma
messages: synaptosome

7955:ube2s
gene id: 7955:ube2s
uniprot id: Q4V908
names: Function
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme ube2c/ubch10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit.

7955:scube1
gene id: 7955:scube1
uniprot id: A0A0R4IBT9
uniprot id: A0A8M1PAA2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:fxyd1
gene id: 7955:fxyd1
uniprot id: A8DZH1
names: Similarity
messages: Belongs to the FXYD family.

7955:mfi2
gene id: 7955:mfi2
uniprot id: A0A8M3B3G9
uniprot id: E7F2E3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferrin family.
messages: Monomer.
messages: Secreted
messages: Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate.

7955:sec61g
gene id: 7955:sec61g
uniprot id: F2Z4R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:bglap
gene id: 7955:bglap
uniprot id: Q4G6A6
names: Similarity
messages: Belongs to the osteocalcin/matrix Gla protein family.

7955:pde4ca
gene id: 7955:pde4ca
uniprot id: A0A8M2BAJ1
uniprot id: A0A8M9P0C0
uniprot id: A0A8M9PPY4
uniprot id: A0A8M9PXB7
uniprot id: A0A8M9Q0N3
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

7955:pdlim3a
gene id: 7955:pdlim3a
uniprot id: Q4VBT3
names: Subcellular Location Annotation
messages: Z line

7955:tfap2e
gene id: 7955:tfap2e
uniprot id: A0A8M9PAV2
uniprot id: Q6P0E7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AP-2 family.
messages: Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity).
messages: Nucleus
messages: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions.

7955:LOC556594
gene id: 7955:LOC556594
uniprot id: A0A8M9PV16
names: Similarity
messages: Belongs to the MAGUK family.

7955:msgn1
gene id: 7955:msgn1
uniprot id: Q90ZL1
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Coexpression of ntl and spt is required for expression.
messages: Expression is first detected in the marginal zone of the blastoderm. Expression becomes more apparent at the germ-ring stage. In the early gastrula, expressed only in hypoblast cells of the germ ring. At mid-gastrula stage, expressed in ventrolateral mesoderm and is subsequently restricted to the segmental plate at late gastrula stage. At the segmentation period, expressed in the presomitic mesoderm including the tailbud. Expression is also detected in the adaxial cells in the vicinity of the presomitic mesoderm.
messages: Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation (By similarity).
messages: Nucleus

7955:myh7bb
gene id: 7955:myh7bb
uniprot id: A0A8M9P5E5
uniprot id: A0A8M9PFC7
uniprot id: E9QF07
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:ddx11
gene id: 7955:ddx11
uniprot id: F1R345
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis. Plays a role in DNA double-strand break (DSB) repair at the DNA replication fork during DNA replication recovery from DNA damage. Plays a role in the regulation of sister chromatid cohesion and mitotic chromosome segregation. Stimulates 5'-single-stranded DNA flap endonuclease activity of FEN1 in an ATP- and helicase-independent manner. Also plays a role in heterochromatin organization (By similarity). Involved in rRNA transcription activation through binding to active hypomethylated rDNA gene loci by recruiting UBTF and the RNA polymerase Pol I transcriptional machinery (PubMed:26089203). Plays a role in embryonic development (PubMed:26089203). Associates with chromatin at DNA replication fork regions. Binds to single- and double-stranded DNAs (By similarity).
messages: Midbody
messages: Morpholino knockdown of the protein leads to abnormal craniofacial and vertebrate development with shortened and twisted torsos, smaller eyes and low mouth positions at 3 days post-fertilization (dpf).
messages: Nucleus
messages: centrosome
messages: nucleolus
messages: spindle pole

7955:gpr37a
gene id: 7955:gpr37a
uniprot id: A0A8M3AZS3
uniprot id: A0A8M9PHD8
uniprot id: E7F3I2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:fat1b
gene id: 7955:fat1b
uniprot id: A0A140LGD3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:usp5
gene id: 7955:usp5
uniprot id: Q1MT86
uniprot id: Q4V973
names: Similarity
messages: Belongs to the peptidase C19 family.

7955:si:ch73-60h1.1
gene id: 7955:si:ch73-60h1.1
uniprot id: A0A8M1RRA7
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:LOC568645
gene id: 7955:LOC568645
uniprot id: A0A8N7UVK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

7955:elavl3
gene id: 7955:elavl3
uniprot id: A0A0R4IC33
uniprot id: A0A8M2BBS5
uniprot id: A0A8M3AYA7
uniprot id: A0A8M6YUY6
uniprot id: A0A8M6YXB4
uniprot id: A0A8M6Z446
uniprot id: P79736
uniprot id: Q6P105
names: Similarity
messages: Belongs to the RRM elav family.

7955:ngdn
gene id: 7955:ngdn
uniprot id: F1REQ4
uniprot id: Q6PFJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SAS10 family.
messages: Cytoplasm
messages: Nucleus
messages: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Its dissociation from the complex determines the transition from state pre-A1 to state pre-A1* (By similarity). May inhibit mRNA translation (By similarity).
messages: axon
messages: centromere
messages: dendrite
messages: filopodium
messages: nucleolus

7955:wrnip1
gene id: 7955:wrnip1
uniprot id: Q6NW46
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

7955:si:dkey-11f12.2
gene id: 7955:si:dkey-11f12.2
uniprot id: E7F782
names: Similarity
messages: Belongs to the mab-21 family.

7955:abcc4
gene id: 7955:abcc4
uniprot id: Q8QFL6
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane

7955:dpysl5a
gene id: 7955:dpysl5a
uniprot id: Q52PJ7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

7955:ptpn4b
gene id: 7955:ptpn4b
uniprot id: A0A8M3B5D0
uniprot id: F1QFY3
uniprot id: Q1MTL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

7955:galns
gene id: 7955:galns
uniprot id: F8W261
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Homodimer.
messages: Lysosome

7955:cox4i1l
gene id: 7955:cox4i1l
uniprot id: F1R6I1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

7955:LOC110438743
gene id: 7955:LOC110438743
uniprot id: A0A8M9P9B1
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

7955:f2rl2
gene id: 7955:f2rl2
uniprot id: F1QQR2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:gabrz
gene id: 7955:gabrz
uniprot id: B0JZB5
uniprot id: F1QZB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:rnf10
gene id: 7955:rnf10
uniprot id: A0A8M2BGH7
uniprot id: B0UXR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF10 family.
messages: Cytoplasm

7955:LOC792939
gene id: 7955:LOC792939
uniprot id: A0A8M9PZI5
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:mrps10
gene id: 7955:mrps10
uniprot id: Q1LVB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Mitochondrion

7955:cx28.9
gene id: 7955:cx28.9
uniprot id: Q5TYN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

7955:atp6ap1a
gene id: 7955:atp6ap1a
uniprot id: F1R9A7
names: Similarity
messages: Belongs to the vacuolar ATPase subunit S1 family.

7955:si:ch73-70c5.1
gene id: 7955:si:ch73-70c5.1
uniprot id: A0A8M2BI52
names: Similarity
messages: Belongs to the EPS8 family.

7955:snx8b
gene id: 7955:snx8b
uniprot id: A0A0R4IDN5
uniprot id: A0A8M9PX28
names: Subcellular Location Annotation
messages: Membrane

7955:lim2.4
gene id: 7955:lim2.4
uniprot id: Q1L960
uniprot id: Q6DH11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

7955:sv2c
gene id: 7955:sv2c
uniprot id: A0A286Y8C7
uniprot id: A2CF25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

7955:tgfb3
gene id: 7955:tgfb3
uniprot id: Q66I23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.
messages: extracellular matrix

7955:tcirg1b
gene id: 7955:tcirg1b
uniprot id: Q7ZVM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

7955:med7
gene id: 7955:med7
uniprot id: Q7ZV35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

7955:ctdspl2b
gene id: 7955:ctdspl2b
uniprot id: A4QNX6
names: Function
names: Similarity
messages: Belongs to the CTDSPL2 family.
messages: Probable phosphatase.

7955:prss12
gene id: 7955:prss12
uniprot id: A0A8M1QHD3
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
messages: Secreted

7955:frzb
gene id: 7955:frzb
uniprot id: Q9W6E0
names: Caution
names: Function
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

7955:LOC110439925
gene id: 7955:LOC110439925
uniprot id: A0A8M9PPD4
names: Similarity
messages: Belongs to the ARTD/PARP family.

7955:si:ch211-285c6.4
gene id: 7955:si:ch211-285c6.4
uniprot id: A0A8M9Q854
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:mcm3l
gene id: 7955:mcm3l
uniprot id: B8JKC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

7955:cldn34a
gene id: 7955:cldn34a
uniprot id: E7FDA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

7955:LOC100536607
gene id: 7955:LOC100536607
uniprot id: E7F5U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL family.
messages: Membrane

7955:LOC101884488
gene id: 7955:LOC101884488
uniprot id: A0A8M2BHM5
names: Caution
names: Similarity
messages: Belongs to the nephronectin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:rbks
gene id: 7955:rbks
uniprot id: Q6IQD5
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

7955:paox1
gene id: 7955:paox1
uniprot id: A0A8M1NH10
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

7955:apitd1
gene id: 7955:apitd1
uniprot id: B3DJV8
names: Similarity
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.

7955:uxt
gene id: 7955:uxt
uniprot id: Q66IA7
names: Similarity
messages: Belongs to the UXT family.

7955:anapc2
gene id: 7955:anapc2
uniprot id: A0A0R4ISV4
names: Similarity
messages: Belongs to the cullin family.

7955:wdfy1
gene id: 7955:wdfy1
uniprot id: Q4VBV0
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

7955:wrb
gene id: 7955:wrb
uniprot id: Q6DRM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WRB/GET1 family.
messages: Component of the Golgi to ER traffic (GET) complex, which is composed of GET1/WRB, CAMLG/GET2 and GET3/TRC40. Within the complex, GET1 and CAMLG form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer.
messages: Endoplasmic reticulum membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER) (By similarity). Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (By similarity). Required to ensure correct topology and ER insertion of CAMLG (By similarity).

7955:zgc:172295
gene id: 7955:zgc:172295
uniprot id: A0A8M2B6K9
uniprot id: A0A8M2B6R0
uniprot id: A0A8M2B752
uniprot id: A0A8M3AHG1
uniprot id: A0A8M3AIJ0
uniprot id: A0A8M3ASS3
uniprot id: A0A8M6Z5P5
uniprot id: A8WGB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

7955:gstcd
gene id: 7955:gstcd
uniprot id: A0A8M1N6W6
names: Similarity
messages: Belongs to the GSTCD family.

7955:si:dkeyp-87d8.8
gene id: 7955:si:dkeyp-87d8.8
uniprot id: A0A8M2B870
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

7955:hnf4g
gene id: 7955:hnf4g
uniprot id: A0A0R4IJK6
uniprot id: A0A8M6YY37
uniprot id: F1QM73
uniprot id: F1RCC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus

7955:rragcb
gene id: 7955:rragcb
uniprot id: A0A0R4IZL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

7955:cd9b
gene id: 7955:cd9b
uniprot id: Q1L9G6
uniprot id: Q7ZUH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Membrane
messages: extracellular exosome

7955:lygl1
gene id: 7955:lygl1
uniprot id: A0A8M2BKV1
uniprot id: Q6DH80
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

7955:zgc:77880
gene id: 7955:zgc:77880
uniprot id: Q6P3H1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

7955:cx52.6
gene id: 7955:cx52.6
uniprot id: A0A8M2B7L5
uniprot id: Q8JHW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

7955:anxa1b
gene id: 7955:anxa1b
uniprot id: Q804H1
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

7955:dcaf17
gene id: 7955:dcaf17
uniprot id: A8WHR0
names: Function
names: Subcellular Location Annotation
messages: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
messages: Membrane
messages: nucleolus

7955:hoxc9a
gene id: 7955:hoxc9a
uniprot id: A2BE65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

7955:cct7
gene id: 7955:cct7
uniprot id: Q8JHG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

7955:si:dkey-215k6.1
gene id: 7955:si:dkey-215k6.1
uniprot id: A0A8N7T6H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

7955:msx1a
gene id: 7955:msx1a
uniprot id: Q90455
names: Subcellular Location Annotation
messages: Nucleus

7955:galnt7
gene id: 7955:galnt7
uniprot id: A0A286YBK3
uniprot id: Q502M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

7955:tubgcp2
gene id: 7955:tubgcp2
uniprot id: Q7SYD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

7955:LOC110438377
gene id: 7955:LOC110438377
uniprot id: A0A8M9P6K9
names: Subcellular Location Annotation
messages: Nucleus

7955:supv3l1
gene id: 7955:supv3l1
uniprot id: A4IG62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family.
messages: Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA (By similarity).
messages: Mitochondrion matrix
messages: Nucleus
messages: mitochondrion nucleoid

7955:polr1c
gene id: 7955:polr1c
uniprot id: Q6PHE7
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

7955:ift57
gene id: 7955:ift57
uniprot id: Q6IVW0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT57 family.
messages: Fishes show ciliary defects. In retina, cilia are generated but not maintained, producing the absence of photoreceptor outer segments. A loss of cilia also occurs in auditory hair cells and olfactory sensory neurons. In all 3 sense organs, cilia defects are followed by degeneration of sensory cells.
messages: Required for the formation of cilia. Essential for differentiation and survival of sensory neurons. May also have pro-apoptotic function.
messages: cilium basal body

7955:rxfp3.2b
gene id: 7955:rxfp3.2b
uniprot id: Q1LXU7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:sult4a1
gene id: 7955:sult4a1
uniprot id: Q1RLU6
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

7955:sart3
gene id: 7955:sart3
uniprot id: B3DJT0
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cajal body
messages: Cytoplasm
messages: Nucleus speckle
messages: The egy mutant embryos that lack detectable sart3 expression display microcephaly, microphthalmia and die by 7 to 8 dpf. Pharyngeal arch formation is defective resulting in a thymus devoid of lymphocytes and exocrine pancreas development is also impaired.
messages: U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:17416673). May also function as a substrate targeting factor for deubiquitinases and mediate the deubiquitination of components of the spliceosome and histones (By similarity).
messages: nucleoplasm

7955:kcnh2b
gene id: 7955:kcnh2b
uniprot id: A0A8M6YY94
names: Subcellular Location Annotation
messages: Membrane

7955:scamp5b
gene id: 7955:scamp5b
uniprot id: A0A8M9PAP2
uniprot id: F1R1Z1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:zgc:172145
gene id: 7955:zgc:172145
uniprot id: A0A8M9PMR3
uniprot id: B1WB56
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

7955:si:dkeyp-75h12.5
gene id: 7955:si:dkeyp-75h12.5
uniprot id: E7FEX9
names: Subcellular Location Annotation
messages: Secreted

7955:ube2d1a
gene id: 7955:ube2d1a
uniprot id: Q7SXH5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7955:lft2
gene id: 7955:lft2
uniprot id: Q9W6I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

7955:rbbp8
gene id: 7955:rbbp8
uniprot id: F1R983
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COM1/SAE2/CtIP family.
messages: Binds one Zn(2+) atom per dimer. Zn(2+)-binding is not required for homotetramerization.
messages: Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA.
messages: Homotetramer; formed by antiparallel association of helical extensions protruding from the N-termini of two parallel coiled-coil dimers (By similarity). Interacts with the MRN complex; the interaction links DNA sensing to resection (By similarity). Interacts with samhd1 (By similarity).
messages: Nucleus

7955:tctex1d1
gene id: 7955:tctex1d1
uniprot id: Q66IC8
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

7955:izumo1
gene id: 7955:izumo1
uniprot id: A0A2R8QHQ6
names: Similarity
messages: Belongs to the Izumo family.

7955:zgc:162160
gene id: 7955:zgc:162160
uniprot id: A3KNK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

7955:snx33
gene id: 7955:snx33
uniprot id: B5RHZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

7955:picalmb
gene id: 7955:picalmb
uniprot id: A0A8M3AHB8
uniprot id: A0A8M3AHC4
uniprot id: A0A8M3AIG6
uniprot id: A0A8M3AIH0
uniprot id: A0A8M3APR9
uniprot id: A0A8M3APS6
uniprot id: A0A8M3ASP1
uniprot id: A0A8M3B104
uniprot id: A0A8M3B110
uniprot id: A0A8M6Z2V9
uniprot id: A0A8M6Z4D6
uniprot id: A0A8M6Z9M1
uniprot id: A0A8M6ZA05
uniprot id: Q6AXI5
names: Similarity
messages: Belongs to the PICALM/SNAP91 family.

7955:hist2h3c
gene id: 7955:hist2h3c
uniprot id: Q4QRF4
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by rag1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:ncor1
gene id: 7955:ncor1
uniprot id: A0A8M2BCM0
uniprot id: A0A8M3ASH4
uniprot id: A0A8M3AZS6
uniprot id: A0A8M3B2M9
uniprot id: A0A8M3B9S7
uniprot id: A8B6H7
names: Similarity
messages: Belongs to the N-CoR nuclear receptor corepressors family.

7955:sfrp2
gene id: 7955:sfrp2
uniprot id: F1R238
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:COX1
gene id: 7955:COX1
uniprot id: A0A0A0VG02
uniprot id: Q9MIY8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 2 heme A groups non-covalently per subunit.
messages: Binds a copper B center.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). As a newly synthesized protein, rapidly incorporates into a multi-subunit assembly intermediate in the inner membrane, called MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase) complex, whose core components are COA3/MITRAC12 and COX14. Within the MITRAC complex, interacts with COA3 and with SMIM20/MITRAC7; the interaction with SMIM20 stabilizes the newly synthesized MT-CO1 and prevents its premature turnover. Interacts with TMEM177 in a COX20-dependent manner (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

7955:gnrhr4
gene id: 7955:gnrhr4
uniprot id: A3QJZ0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:npm2a
gene id: 7955:npm2a
uniprot id: B0UYT8
names: Similarity
messages: Belongs to the nucleoplasmin family.

7955:acta2
gene id: 7955:acta2
uniprot id: Q6DHS1
names: Similarity
messages: Belongs to the actin family.

7955:clcn6
gene id: 7955:clcn6
uniprot id: E7F798
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

7955:meox2a
gene id: 7955:meox2a
uniprot id: E7FEH1
names: Subcellular Location Annotation
messages: Nucleus

7955:smpdl3a
gene id: 7955:smpdl3a
uniprot id: A0A8M2BHJ3
uniprot id: A0A8M3AWG3
uniprot id: Q58EN0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

7955:gmpr
gene id: 7955:gmpr
uniprot id: Q503G5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

7955:ero1b
gene id: 7955:ero1b
uniprot id: A0A8M2BK75
uniprot id: Q08CJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

7955:ttc38
gene id: 7955:ttc38
uniprot id: A0A8M2B5G9
uniprot id: A3KPN8
names: Similarity
messages: Belongs to the TTC38 family.

7955:armt1
gene id: 7955:armt1
uniprot id: B2GSN3
uniprot id: Q58EM4
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
messages: Automethylated.
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Human C6orf211 has been reportedly associated with a protein carboxyl methyltransferase activity, but whether this protein indeed has such an activity remains to be determined (By similarity). It has been later shown to belong to a family of metal-dependent phosphatases implicated in metabolite damage-control (By similarity).
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (By similarity). Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (By similarity). Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues (By similarity). Possibly methylates PCNA, suggesting it is involved in the DNA damage response (By similarity).
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

7955:lmbrd1
gene id: 7955:lmbrd1
uniprot id: Q5PR61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIMR family. LMBRD1 subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors. Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome. Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (By similarity). May play a role in mediating and regulating the internalization of the insulin receptor (By similarity).
messages: Lysosome membrane

7955:abcc9
gene id: 7955:abcc9
uniprot id: A0A0R4IAS5
uniprot id: A0A8M2BBT3
uniprot id: A0A8M2BBV1
uniprot id: A0A8M2BBZ7
uniprot id: A0A8M2BC16
uniprot id: A0A8M6YY04
uniprot id: A0A8M6Z5C5
uniprot id: Q5RH87
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with KCNJ11.
messages: Membrane

7955:gprc5ba
gene id: 7955:gprc5ba
uniprot id: X1WEL2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:myhc4
gene id: 7955:myhc4
uniprot id: A2BGX6
uniprot id: Q508P7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.