767817:DESGI RS08560
gene id: 767817:DESGI_RS08560
uniprot id: R4KHX8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. SigI subfamily.
messages: Cytoplasm
messages: Interacts with RsgI.
messages: Negatively regulated by the anti-sigma-I factor RsgI.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

767817:DESGI RS09490
gene id: 767817:DESGI_RS09490
uniprot id: R4KFQ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

767817:DESGI RS14025
gene id: 767817:DESGI_RS14025
uniprot id: R4KGI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

767817:DESGI RS10465
gene id: 767817:DESGI_RS10465
uniprot id: R4KEK7
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

767817:DESGI RS15955
gene id: 767817:DESGI_RS15955
uniprot id: R4KJA6
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS22065
gene id: 767817:DESGI_RS22065
uniprot id: R4KKY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

767817:DESGI RS04215
gene id: 767817:DESGI_RS04215
uniprot id: R4KB79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS17400
gene id: 767817:DESGI_RS17400
uniprot id: R4KTQ6
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS04110
gene id: 767817:DESGI_RS04110
uniprot id: R4KB60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

767817:DESGI RS11695
gene id: 767817:DESGI_RS11695
uniprot id: R4KGX9
names: Similarity
messages: Belongs to the phosphohexose mutase family.

767817:DESGI RS13125
gene id: 767817:DESGI_RS13125
uniprot id: R4KHQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

767817:DESGI RS20365
gene id: 767817:DESGI_RS20365
uniprot id: R4KVA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

767817:DESGI RS21935
gene id: 767817:DESGI_RS21935
uniprot id: R4KW43
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS21665
gene id: 767817:DESGI_RS21665
uniprot id: R4KT63
names: Similarity
messages: Belongs to the ABC transporter superfamily.

767817:DESGI RS09875
gene id: 767817:DESGI_RS09875
uniprot id: R4KLW7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

767817:DESGI RS17495
gene id: 767817:DESGI_RS17495
uniprot id: R4KN81
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS06510
gene id: 767817:DESGI_RS06510
uniprot id: R4KGV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

767817:DESGI RS22950
gene id: 767817:DESGI_RS22950
uniprot id: R4KC33
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS09205
gene id: 767817:DESGI_RS09205
uniprot id: R4KIC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

767817:DESGI RS03460
gene id: 767817:DESGI_RS03460
uniprot id: R4KKX1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

767817:DESGI RS06110
gene id: 767817:DESGI_RS06110
uniprot id: R4KGL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane
messages: Membrane

767817:DESGI RS14550
gene id: 767817:DESGI_RS14550
uniprot id: R4KPC0
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS12230
gene id: 767817:DESGI_RS12230
uniprot id: R4KFL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

767817:DESGI RS22585
gene id: 767817:DESGI_RS22585
uniprot id: R4KR00
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

767817:DESGI RS08945
gene id: 767817:DESGI_RS08945
uniprot id: R4KLB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

767817:DESGI RS18515
gene id: 767817:DESGI_RS18515
uniprot id: R4KJ03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AmiS/UreI family.
messages: Membrane

767817:DESGI RS13815
gene id: 767817:DESGI_RS13815
uniprot id: R4KGE5
names: Similarity
messages: Belongs to the glutamate synthase family.

767817:DESGI RS07720
gene id: 767817:DESGI_RS07720
uniprot id: R4KEU6
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

767817:DESGI RS21820
gene id: 767817:DESGI_RS21820
uniprot id: R4KQJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

767817:DESGI RS20655
gene id: 767817:DESGI_RS20655
uniprot id: R4KSN3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

767817:DESGI RS08320
gene id: 767817:DESGI_RS08320
uniprot id: R4KTH6
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

767817:DESGI RS12645
gene id: 767817:DESGI_RS12645
uniprot id: R4KKF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

767817:DESGI RS09015
gene id: 767817:DESGI_RS09015
uniprot id: R4KDU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

767817:DESGI RS20335
gene id: 767817:DESGI_RS20335
uniprot id: R4KLJ8
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

767817:DESGI RS03585
gene id: 767817:DESGI_RS03585
uniprot id: R4KKZ8
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

767817:DESGI RS12300
gene id: 767817:DESGI_RS12300
uniprot id: R4KFN1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

767817:DESGI RS12415
gene id: 767817:DESGI_RS12415
uniprot id: R4KKB6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

767817:DESGI RS07060
gene id: 767817:DESGI_RS07060
uniprot id: R4KEG4
names: Similarity
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.

767817:DESGI RS02275
gene id: 767817:DESGI_RS02275
uniprot id: R4KBW5
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

767817:DESGI RS05100
gene id: 767817:DESGI_RS05100
uniprot id: R4KJC5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

767817:DESGI RS15700
gene id: 767817:DESGI_RS15700
uniprot id: R4KJ54
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

767817:DESGI RS20035
gene id: 767817:DESGI_RS20035
uniprot id: R4KLD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS13060
gene id: 767817:DESGI_RS13060
uniprot id: R4KR94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

767817:DESGI RS04400
gene id: 767817:DESGI_RS04400
uniprot id: R4KIV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

767817:DESGI RS01715
gene id: 767817:DESGI_RS01715
uniprot id: R4KHB3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

767817:DESGI RS21915
gene id: 767817:DESGI_RS21915
uniprot id: R4KQL7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

767817:DESGI RS11750
gene id: 767817:DESGI_RS11750
uniprot id: R4KMU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

767817:DESGI RS09020
gene id: 767817:DESGI_RS09020
uniprot id: R4KFH3
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

767817:DESGI RS06655
gene id: 767817:DESGI_RS06655
uniprot id: R4KMP9
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS11715
gene id: 767817:DESGI_RS11715
uniprot id: R4KFA9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

767817:DESGI RS13630
gene id: 767817:DESGI_RS13630
uniprot id: R4KRL6
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS17390
gene id: 767817:DESGI_RS17390
uniprot id: R4KIG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

767817:DESGI RS02465
gene id: 767817:DESGI_RS02465
uniprot id: R4KBZ5
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

767817:DESGI RS17360
gene id: 767817:DESGI_RS17360
uniprot id: R4KN28
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS09150
gene id: 767817:DESGI_RS09150
uniprot id: R4KP14
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

767817:DESGI RS18975
gene id: 767817:DESGI_RS18975
uniprot id: R4KNY8
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

767817:DESGI RS13675
gene id: 767817:DESGI_RS13675
uniprot id: R4KNX1
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS16990
gene id: 767817:DESGI_RS16990
uniprot id: R4KMV4
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

767817:DESGI RS08035
gene id: 767817:DESGI_RS08035
uniprot id: R4KEZ9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

767817:DESGI RS18015
gene id: 767817:DESGI_RS18015
uniprot id: R4KKD3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. AddA subfamily.
messages: Heterodimer of AddA and AddB/RexB.
messages: The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.

767817:DESGI RS06340
gene id: 767817:DESGI_RS06340
uniprot id: R4KE33
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

767817:DESGI RS10635
gene id: 767817:DESGI_RS10635
uniprot id: R4KJ58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

767817:DESGI RS08765
gene id: 767817:DESGI_RS08765
uniprot id: R4KDN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

767817:DESGI RS00975
gene id: 767817:DESGI_RS00975
uniprot id: R4KDP4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

767817:DESGI RS11890
gene id: 767817:DESGI_RS11890
uniprot id: R4KQI4
names: Similarity
messages: Belongs to the GARS family.

767817:DESGI RS06630
gene id: 767817:DESGI_RS06630
uniprot id: R4KMP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

767817:DESGI RS14835
gene id: 767817:DESGI_RS14835
uniprot id: R4KLP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Membrane

767817:DESGI RS19685
gene id: 767817:DESGI_RS19685
uniprot id: R4KL58
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS10755
gene id: 767817:DESGI_RS10755
uniprot id: R4KMC6
names: Similarity
messages: Belongs to the HepT RNase toxin family.

767817:DESGI RS05885
gene id: 767817:DESGI_RS05885
uniprot id: R4KDU6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

767817:DESGI RS09320
gene id: 767817:DESGI_RS09320
uniprot id: R4KLH5
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

767817:DESGI RS10255
gene id: 767817:DESGI_RS10255
uniprot id: R4KM39
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

767817:DESGI RS02775
gene id: 767817:DESGI_RS02775
uniprot id: R4KKI3
names: Similarity
messages: Belongs to the FBPase class 2 family.

767817:DESGI RS03220
gene id: 767817:DESGI_RS03220
uniprot id: R4KI82
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

767817:DESGI RS03745
gene id: 767817:DESGI_RS03745
uniprot id: R4KFA1
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

767817:DESGI RS13405
gene id: 767817:DESGI_RS13405
uniprot id: R4KNS5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

767817:DESGI RS17295
gene id: 767817:DESGI_RS17295
uniprot id: R4KID5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

767817:DESGI RS12575
gene id: 767817:DESGI_RS12575
uniprot id: R4KHG9
names: Similarity
messages: Belongs to the peptidase U62 family.

767817:DESGI RS13980
gene id: 767817:DESGI_RS13980
uniprot id: R4KRT5
names: Similarity
messages: Belongs to the xanthine dehydrogenase family.

767817:DESGI RS13075
gene id: 767817:DESGI_RS13075
uniprot id: R4KHP8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

767817:DESGI RS10500
gene id: 767817:DESGI_RS10500
uniprot id: R4KM83
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

767817:DESGI RS06540
gene id: 767817:DESGI_RS06540
uniprot id: R4KCH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS07745
gene id: 767817:DESGI_RS07745
uniprot id: R4KD53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

767817:DESGI RS08740
gene id: 767817:DESGI_RS08740
uniprot id: R4KDN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

767817:DESGI RS20575
gene id: 767817:DESGI_RS20575
uniprot id: R4KK50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation.

767817:DESGI RS06090
gene id: 767817:DESGI_RS06090
uniprot id: R4KC83
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

767817:DESGI RS10540
gene id: 767817:DESGI_RS10540
uniprot id: R4KEM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

767817:DESGI RS13435
gene id: 767817:DESGI_RS13435
uniprot id: R4KRH4
names: Similarity
messages: Belongs to the oxoprolinase family.

767817:DESGI RS11865
gene id: 767817:DESGI_RS11865
uniprot id: R4KQH9
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

767817:DESGI RS05815
gene id: 767817:DESGI_RS05815
uniprot id: R4KM85
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

767817:DESGI RS16260
gene id: 767817:DESGI_RS16260
uniprot id: R4KQA8
names: Similarity
messages: Belongs to the TPP enzyme family.

767817:DESGI RS03815
gene id: 767817:DESGI_RS03815
uniprot id: R4KII8
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

767817:DESGI RS21775
gene id: 767817:DESGI_RS21775
uniprot id: R4KQI7
names: Similarity
messages: Belongs to the peptidase S8 family.

767817:DESGI RS08150
gene id: 767817:DESGI_RS08150
uniprot id: R4KKY6
names: Similarity
messages: Belongs to the SfsA family.

767817:DESGI RS13260
gene id: 767817:DESGI_RS13260
uniprot id: R4KHT1
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

767817:DESGI RS21735
gene id: 767817:DESGI_RS21735
uniprot id: R4KM89
names: Similarity
messages: Belongs to the YoeB family.

767817:DESGI RS09475
gene id: 767817:DESGI_RS09475
uniprot id: R4KP76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane

767817:DESGI RS14590
gene id: 767817:DESGI_RS14590
uniprot id: R4KGW5
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

767817:DESGI RS11180
gene id: 767817:DESGI_RS11180
uniprot id: R4KEZ6
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS01395
gene id: 767817:DESGI_RS01395
uniprot id: R4KBC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

767817:DESGI RS13610
gene id: 767817:DESGI_RS13610
uniprot id: R4KKZ5
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS06470
gene id: 767817:DESGI_RS06470
uniprot id: R4KK03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS02405
gene id: 767817:DESGI_RS02405
uniprot id: R4KKB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

767817:DESGI RS19300
gene id: 767817:DESGI_RS19300
uniprot id: R4KUN5
names: Similarity
messages: Belongs to the EamA transporter family.

767817:DESGI RS11635
gene id: 767817:DESGI_RS11635
uniprot id: R4KJR9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS07960
gene id: 767817:DESGI_RS07960
uniprot id: R4KKV6
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

767817:DESGI RS06195
gene id: 767817:DESGI_RS06195
uniprot id: R4KE06
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

767817:DESGI RS03910
gene id: 767817:DESGI_RS03910
uniprot id: R4KIK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS14390
gene id: 767817:DESGI_RS14390
uniprot id: R4KP93
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

767817:DESGI RS13190
gene id: 767817:DESGI_RS13190
uniprot id: R4KKQ9
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage.

767817:DESGI RS15750
gene id: 767817:DESGI_RS15750
uniprot id: R4KJ63
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

767817:DESGI RS15415
gene id: 767817:DESGI_RS15415
uniprot id: R4KSM6
names: Similarity
messages: Belongs to the HepT RNase toxin family.

767817:DESGI RS20540
gene id: 767817:DESGI_RS20540
uniprot id: R4KVD4
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

767817:DESGI RS06665
gene id: 767817:DESGI_RS06665
uniprot id: R4KCK2
names: Similarity
messages: Belongs to the CdaR family.

767817:DESGI RS12395
gene id: 767817:DESGI_RS12395
uniprot id: R4KFR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

767817:DESGI RS02230
gene id: 767817:DESGI_RS02230
uniprot id: R4KEG0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

767817:DESGI RS09420
gene id: 767817:DESGI_RS09420
uniprot id: R4KFP6
names: Similarity
messages: Belongs to the HdrA family.

767817:DESGI RS12965
gene id: 767817:DESGI_RS12965
uniprot id: R4KKL2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

767817:DESGI RS19990
gene id: 767817:DESGI_RS19990
uniprot id: R4KS90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

767817:DESGI RS13505
gene id: 767817:DESGI_RS13505
uniprot id: R4KNU2
names: Similarity
messages: Belongs to the ABC transporter superfamily.

767817:DESGI RS04360
gene id: 767817:DESGI_RS04360
uniprot id: R4KBB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS17655
gene id: 767817:DESGI_RS17655
uniprot id: R4KR55
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

767817:DESGI RS02455
gene id: 767817:DESGI_RS02455
uniprot id: R4KEI5
names: Similarity
messages: Belongs to the AOR/FOR family.

767817:DESGI RS20435
gene id: 767817:DESGI_RS20435
uniprot id: R4KVB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

767817:DESGI RS19865
gene id: 767817:DESGI_RS19865
uniprot id: R4KJQ7
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

767817:DESGI RS10310
gene id: 767817:DESGI_RS10310
uniprot id: R4KEI4
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

767817:DESGI RS10275
gene id: 767817:DESGI_RS10275
uniprot id: R4KM44
names: Similarity
messages: Belongs to the threonine synthase family.

767817:DESGI RS21835
gene id: 767817:DESGI_RS21835
uniprot id: R4KT97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

767817:DESGI RS08800
gene id: 767817:DESGI_RS08800
uniprot id: R4KNU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

767817:DESGI RS17640
gene id: 767817:DESGI_RS17640
uniprot id: R4KNA4
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS11550
gene id: 767817:DESGI_RS11550
uniprot id: R4KMR0
names: Function
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).

767817:DESGI RS15625
gene id: 767817:DESGI_RS15625
uniprot id: R4KJ41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

767817:DESGI RS10475
gene id: 767817:DESGI_RS10475
uniprot id: R4KM78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

767817:DESGI RS10000
gene id: 767817:DESGI_RS10000
uniprot id: R4KG29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
messages: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
messages: Cytoplasm
messages: Homodimer.

767817:DESGI RS01610
gene id: 767817:DESGI_RS01610
uniprot id: R4K9S7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS07365
gene id: 767817:DESGI_RS07365
uniprot id: R4KD07
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS17960
gene id: 767817:DESGI_RS17960
uniprot id: R4KIR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

767817:DESGI RS14270
gene id: 767817:DESGI_RS14270
uniprot id: R4KP78
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS19920
gene id: 767817:DESGI_RS19920
uniprot id: R4KS75
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

767817:DESGI RS12970
gene id: 767817:DESGI_RS12970
uniprot id: R4KFY1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

767817:DESGI RS05710
gene id: 767817:DESGI_RS05710
uniprot id: R4KGD9
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

767817:DESGI RS08690
gene id: 767817:DESGI_RS08690
uniprot id: R4KDM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

767817:DESGI RS13885
gene id: 767817:DESGI_RS13885
uniprot id: R4KL50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

767817:DESGI RS02265
gene id: 767817:DESGI_RS02265
uniprot id: R4KEG3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

767817:DESGI RS03175
gene id: 767817:DESGI_RS03175
uniprot id: R4KI75
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

767817:DESGI RS12135
gene id: 767817:DESGI_RS12135
uniprot id: R4KH55
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

767817:DESGI RS16530
gene id: 767817:DESGI_RS16530
uniprot id: R4KHX3
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

767817:DESGI RS21410
gene id: 767817:DESGI_RS21410
uniprot id: R4KKJ1
names: Similarity
messages: Belongs to the peptidase S14 family.

767817:DESGI RS06375
gene id: 767817:DESGI_RS06375
uniprot id: R4KMJ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

767817:DESGI RS03295
gene id: 767817:DESGI_RS03295
uniprot id: R4KKT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS02055
gene id: 767817:DESGI_RS02055
uniprot id: R4KBT6
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS17030
gene id: 767817:DESGI_RS17030
uniprot id: R4KQP6
names: Similarity
messages: Belongs to the peptidase M29 family.

767817:DESGI RS00080
gene id: 767817:DESGI_RS00080
uniprot id: R4KJ29
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

767817:DESGI RS08255
gene id: 767817:DESGI_RS08255
uniprot id: R4KHS0
names: Similarity
messages: Belongs to the peptidase S11 family.

767817:DESGI RS17455
gene id: 767817:DESGI_RS17455
uniprot id: R4KN73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

767817:DESGI RS06220
gene id: 767817:DESGI_RS06220
uniprot id: R4KE10
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

767817:DESGI RS06185
gene id: 767817:DESGI_RS06185
uniprot id: R4KGM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS08135
gene id: 767817:DESGI_RS08135
uniprot id: R4KHQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Cytoplasm

767817:DESGI RS10130
gene id: 767817:DESGI_RS10130
uniprot id: R4KM17
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

767817:DESGI RS21330
gene id: 767817:DESGI_RS21330
uniprot id: R4KSZ3
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS11250
gene id: 767817:DESGI_RS11250
uniprot id: R4KF12
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS09950
gene id: 767817:DESGI_RS09950
uniprot id: R4KLY3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

767817:DESGI RS08735
gene id: 767817:DESGI_RS08735
uniprot id: R4KI20
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

767817:DESGI RS15870
gene id: 767817:DESGI_RS15870
uniprot id: R4KSW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

767817:DESGI RS17285
gene id: 767817:DESGI_RS17285
uniprot id: R4KTM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U4 family.
messages: Cell membrane
messages: Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR.

767817:DESGI RS15715
gene id: 767817:DESGI_RS15715
uniprot id: R4KM73
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

767817:DESGI RS08615
gene id: 767817:DESGI_RS08615
uniprot id: R4KDK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS11305
gene id: 767817:DESGI_RS11305
uniprot id: R4KGQ7
names: Similarity
messages: Belongs to the glutamate synthase family.

767817:DESGI RS16025
gene id: 767817:DESGI_RS16025
uniprot id: R4KHM5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

767817:DESGI RS17915
gene id: 767817:DESGI_RS17915
uniprot id: R4KKB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

767817:DESGI RS06430
gene id: 767817:DESGI_RS06430
uniprot id: R4KGT3
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

767817:DESGI RS15270
gene id: 767817:DESGI_RS15270
uniprot id: R4KSK4
names: Similarity
messages: Belongs to the serpin family.

767817:DESGI RS03060
gene id: 767817:DESGI_RS03060
uniprot id: R4KEV4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

767817:DESGI RS10210
gene id: 767817:DESGI_RS10210
uniprot id: R4KM32
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

767817:DESGI RS09190
gene id: 767817:DESGI_RS09190
uniprot id: R4KFK7
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

767817:DESGI RS20670
gene id: 767817:DESGI_RS20670
uniprot id: R4KK65
names: Similarity
messages: Belongs to the UDPGP type 2 family.

767817:DESGI RS15170
gene id: 767817:DESGI_RS15170
uniprot id: R4KLX5
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

767817:DESGI RS15675
gene id: 767817:DESGI_RS15675
uniprot id: R4KJ51
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

767817:DESGI RS21670
gene id: 767817:DESGI_RS21670
uniprot id: R4KVY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS18525
gene id: 767817:DESGI_RS18525
uniprot id: R4KKL0
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

767817:DESGI RS01830
gene id: 767817:DESGI_RS01830
uniprot id: R4K9W8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

767817:DESGI RS01150
gene id: 767817:DESGI_RS01150
uniprot id: R4KJM8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

767817:DESGI RS16075
gene id: 767817:DESGI_RS16075
uniprot id: R4KJC9
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

767817:DESGI RS14795
gene id: 767817:DESGI_RS14795
uniprot id: R4KLM8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

767817:DESGI RS17715
gene id: 767817:DESGI_RS17715
uniprot id: R4KIN8
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

767817:DESGI RS04165
gene id: 767817:DESGI_RS04165
uniprot id: R4KCV5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

767817:DESGI RS16010
gene id: 767817:DESGI_RS16010
uniprot id: R4KJB6
names: Similarity
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.

767817:DESGI RS09225
gene id: 767817:DESGI_RS09225
uniprot id: R4KP28
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

767817:DESGI RS06785
gene id: 767817:DESGI_RS06785
uniprot id: R4KCM6
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

767817:DESGI RS05340
gene id: 767817:DESGI_RS05340
uniprot id: R4KLY6
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS10095
gene id: 767817:DESGI_RS10095
uniprot id: R4KEF3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

767817:DESGI RS08490
gene id: 767817:DESGI_RS08490
uniprot id: R4KF69
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

767817:DESGI RS23135
gene id: 767817:DESGI_RS23135
uniprot id: R4KNW3
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS08585
gene id: 767817:DESGI_RS08585
uniprot id: R4KHY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MurCDEF family. MurT subfamily.
messages: Forms a heterodimer with GatD.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.

767817:DESGI RS07760
gene id: 767817:DESGI_RS07760
uniprot id: R4KNA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

767817:DESGI RS05670
gene id: 767817:DESGI_RS05670
uniprot id: R4KDR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

767817:DESGI RS12045
gene id: 767817:DESGI_RS12045
uniprot id: R4KQL6
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

767817:DESGI RS08510
gene id: 767817:DESGI_RS08510
uniprot id: R4KDH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

767817:DESGI RS02710
gene id: 767817:DESGI_RS02710
uniprot id: R4KAC4
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS06880
gene id: 767817:DESGI_RS06880
uniprot id: R4KCP9
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

767817:DESGI RS20610
gene id: 767817:DESGI_RS20610
uniprot id: R4KVE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

767817:DESGI RS22640
gene id: 767817:DESGI_RS22640
uniprot id: R4KLB0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpA which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpB RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpA.
messages: Has an N-terminal Jag-N domain and 2 RNA-binding domains (KH and R3H).

767817:DESGI RS05285
gene id: 767817:DESGI_RS05285
uniprot id: R4KDI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

767817:DESGI RS00575
gene id: 767817:DESGI_RS00575
uniprot id: R4KJC7
names: Function
names: Similarity
messages: Belongs to the SpoVG family.
messages: Could be involved in septation.

767817:DESGI RS13475
gene id: 767817:DESGI_RS13475
uniprot id: R4KHY1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

767817:DESGI RS10780
gene id: 767817:DESGI_RS10780
uniprot id: R4KGG4
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

767817:DESGI RS21750
gene id: 767817:DESGI_RS21750
uniprot id: R4KQI2
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

767817:DESGI RS08745
gene id: 767817:DESGI_RS08745
uniprot id: R4KFB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

767817:DESGI RS20550
gene id: 767817:DESGI_RS20550
uniprot id: R4KK47
names: Similarity
messages: Belongs to the HAM1 NTPase family.

767817:DESGI RS06615
gene id: 767817:DESGI_RS06615
uniprot id: R4KCI9
names: Similarity
messages: Belongs to the UPF0045 family.

767817:DESGI RS08080
gene id: 767817:DESGI_RS08080
uniprot id: R4KDA8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

767817:DESGI RS00245
gene id: 767817:DESGI_RS00245
uniprot id: R4KAT3
names: Subcellular Location Annotation
messages: Cytoplasm

767817:DESGI RS07395
gene id: 767817:DESGI_RS07395
uniprot id: R4KEP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

767817:DESGI RS02290
gene id: 767817:DESGI_RS02290
uniprot id: R4KEG6
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

767817:DESGI RS12810
gene id: 767817:DESGI_RS12810
uniprot id: R4KHK6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

767817:DESGI RS18955
gene id: 767817:DESGI_RS18955
uniprot id: R4KJ77
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

767817:DESGI RS09200
gene id: 767817:DESGI_RS09200
uniprot id: R4KP23
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

767817:DESGI RS15975
gene id: 767817:DESGI_RS15975
uniprot id: R4KHL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

767817:DESGI RS02825
gene id: 767817:DESGI_RS02825
uniprot id: R4KI14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homodimer.

767817:DESGI RS04445
gene id: 767817:DESGI_RS04445
uniprot id: R4KIX1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

767817:DESGI RS14205
gene id: 767817:DESGI_RS14205
uniprot id: R4KIC1
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS13690
gene id: 767817:DESGI_RS13690
uniprot id: R4KGB9
names: Similarity
messages: Belongs to the PspA/IM30 family.

767817:DESGI RS17365
gene id: 767817:DESGI_RS17365
uniprot id: R4KIF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

767817:DESGI RS00270
gene id: 767817:DESGI_RS00270
uniprot id: R4KD98
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS18445
gene id: 767817:DESGI_RS18445
uniprot id: R4KU88
names: Similarity
messages: Belongs to the CdaR family.

767817:DESGI RS07065
gene id: 767817:DESGI_RS07065
uniprot id: R4KKB0
names: Similarity
messages: Belongs to the GerABKA family.

767817:DESGI RS08670
gene id: 767817:DESGI_RS08670
uniprot id: R4KFA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CodY family.
messages: Cytoplasm
messages: DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability. During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion.

767817:DESGI RS13945
gene id: 767817:DESGI_RS13945
uniprot id: R4KRT0
names: Similarity
messages: Belongs to the AlaDH/PNT family.

767817:DESGI RS07385
gene id: 767817:DESGI_RS07385
uniprot id: R4KHC8
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS20285
gene id: 767817:DESGI_RS20285
uniprot id: R4KLJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

767817:DESGI RS10195
gene id: 767817:DESGI_RS10195
uniprot id: R4KIX5
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

767817:DESGI RS09290
gene id: 767817:DESGI_RS09290
uniprot id: R4KFM3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

767817:DESGI RS10695
gene id: 767817:DESGI_RS10695
uniprot id: R4KJ70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

767817:DESGI RS05880
gene id: 767817:DESGI_RS05880
uniprot id: R4KC38
names: Similarity
messages: Belongs to the CFA/CMAS family.

767817:DESGI RS18615
gene id: 767817:DESGI_RS18615
uniprot id: R4KRK7
names: Similarity
messages: Belongs to the AOR/FOR family.

767817:DESGI RS20400
gene id: 767817:DESGI_RS20400
uniprot id: R4KLK7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

767817:DESGI RS22615
gene id: 767817:DESGI_RS22615
uniprot id: R4KLA4
names: Similarity
messages: Belongs to the ParB family.

767817:DESGI RS11255
gene id: 767817:DESGI_RS11255
uniprot id: R4KGP7
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

767817:DESGI RS12430
gene id: 767817:DESGI_RS12430
uniprot id: R4KNA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

767817:DESGI RS06600
gene id: 767817:DESGI_RS06600
uniprot id: R4KK22
names: Similarity
messages: Belongs to the GerABKA family.

767817:DESGI RS03355
gene id: 767817:DESGI_RS03355
uniprot id: R4KIA8
names: Similarity
messages: Belongs to the peptidase S8 family.

767817:DESGI RS15540
gene id: 767817:DESGI_RS15540
uniprot id: R4KPX0
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

767817:DESGI RS14045
gene id: 767817:DESGI_RS14045
uniprot id: R4KRU7
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

767817:DESGI RS09360
gene id: 767817:DESGI_RS09360
uniprot id: R4KE15
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

767817:DESGI RS08245
gene id: 767817:DESGI_RS08245
uniprot id: R4KKZ4
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS15585
gene id: 767817:DESGI_RS15585
uniprot id: R4KSQ4
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

767817:DESGI RS01820
gene id: 767817:DESGI_RS01820
uniprot id: R4KJZ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

767817:DESGI RS13600
gene id: 767817:DESGI_RS13600
uniprot id: R4KNW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

767817:DESGI RS22070
gene id: 767817:DESGI_RS22070
uniprot id: R4KMF9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

767817:DESGI RS06635
gene id: 767817:DESGI_RS06635
uniprot id: R4KGX2
names: Similarity
messages: Belongs to the peptidase A31 family.

767817:DESGI RS15810
gene id: 767817:DESGI_RS15810
uniprot id: R4KHI3
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

767817:DESGI RS03535
gene id: 767817:DESGI_RS03535
uniprot id: R4KKY7
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

767817:DESGI RS20495
gene id: 767817:DESGI_RS20495
uniprot id: R4KPV5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

767817:DESGI RS13185
gene id: 767817:DESGI_RS13185
uniprot id: R4KRC0
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

767817:DESGI RS00320
gene id: 767817:DESGI_RS00320
uniprot id: R4KJ74
names: Similarity
messages: Belongs to the UxaA family.

767817:DESGI RS16045
gene id: 767817:DESGI_RS16045
uniprot id: R4KMD8
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS08730
gene id: 767817:DESGI_RS08730
uniprot id: R4KNS8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

767817:DESGI RS08825
gene id: 767817:DESGI_RS08825
uniprot id: R4KNU8
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

767817:DESGI RS20310
gene id: 767817:DESGI_RS20310
uniprot id: R4KLJ3
names: Cofactor
names: Similarity
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.

767817:DESGI RS07505
gene id: 767817:DESGI_RS07505
uniprot id: R4KER1
names: Similarity
messages: Belongs to the glutamate synthase family.

767817:DESGI RS14075
gene id: 767817:DESGI_RS14075
uniprot id: R4KL82
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS00775
gene id: 767817:DESGI_RS00775
uniprot id: R4KB26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

767817:DESGI RS16130
gene id: 767817:DESGI_RS16130
uniprot id: R4KQ84
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

767817:DESGI RS07530
gene id: 767817:DESGI_RS07530
uniprot id: R4KER6
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

767817:DESGI RS16005
gene id: 767817:DESGI_RS16005
uniprot id: R4KHL8
names: Similarity
messages: Belongs to the GerABKC lipoprotein family.

767817:DESGI RS23120
gene id: 767817:DESGI_RS23120
uniprot id: R4KKR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

767817:DESGI RS08780
gene id: 767817:DESGI_RS08780
uniprot id: R4KNT8
names: Similarity
messages: Belongs to the ribF family.

767817:DESGI RS04880
gene id: 767817:DESGI_RS04880
uniprot id: R4KJ88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

767817:DESGI RS04125
gene id: 767817:DESGI_RS04125
uniprot id: R4KLA2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

767817:DESGI RS02415
gene id: 767817:DESGI_RS02415
uniprot id: R4KBY5
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

767817:DESGI RS11350
gene id: 767817:DESGI_RS11350
uniprot id: R4KJK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

767817:DESGI RS00035
gene id: 767817:DESGI_RS00035
uniprot id: R4KJ25
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

767817:DESGI RS04835
gene id: 767817:DESGI_RS04835
uniprot id: R4KFX7
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

767817:DESGI RS00595
gene id: 767817:DESGI_RS00595
uniprot id: R4KGU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

767817:DESGI RS10460
gene id: 767817:DESGI_RS10460
uniprot id: R4KJ23
names: Similarity
messages: Belongs to the manganese catalase family.

767817:DESGI RS18940
gene id: 767817:DESGI_RS18940
uniprot id: R4KRR4
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

767817:DESGI RS15695
gene id: 767817:DESGI_RS15695
uniprot id: R4KHF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

767817:DESGI RS04310
gene id: 767817:DESGI_RS04310
uniprot id: R4KCY5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

767817:DESGI RS00345
gene id: 767817:DESGI_RS00345
uniprot id: R4KJ79
names: Similarity
messages: Belongs to the class-I fumarase family.

767817:DESGI RS01390
gene id: 767817:DESGI_RS01390
uniprot id: R4K9N7
names: Caution
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
messages: Belongs to the biotin--protein ligase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS02635
gene id: 767817:DESGI_RS02635
uniprot id: R4KC29
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

767817:DESGI RS12540
gene id: 767817:DESGI_RS12540
uniprot id: R4KKD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

767817:DESGI RS03310
gene id: 767817:DESGI_RS03310
uniprot id: R4KI98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

767817:DESGI RS00110
gene id: 767817:DESGI_RS00110
uniprot id: R4K8Y7
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

767817:DESGI RS22035
gene id: 767817:DESGI_RS22035
uniprot id: R4KQP0
names: Similarity
messages: Belongs to the peptidase S49 family.

767817:DESGI RS09405
gene id: 767817:DESGI_RS09405
uniprot id: R4KP61
names: Similarity
messages: Belongs to the AOR/FOR family.

767817:DESGI RS01525
gene id: 767817:DESGI_RS01525
uniprot id: R4KBE7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

767817:DESGI RS12480
gene id: 767817:DESGI_RS12480
uniprot id: R4KNB6
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

767817:DESGI RS00015
gene id: 767817:DESGI_RS00015
uniprot id: R4KD56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

767817:DESGI RS09115
gene id: 767817:DESGI_RS09115
uniprot id: R4KDW2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

767817:DESGI RS21930
gene id: 767817:DESGI_RS21930
uniprot id: R4KTB6
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

767817:DESGI RS09635
gene id: 767817:DESGI_RS09635
uniprot id: R4KIL2
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

767817:DESGI RS21965
gene id: 767817:DESGI_RS21965
uniprot id: R4KQM7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

767817:DESGI RS22120
gene id: 767817:DESGI_RS22120
uniprot id: R4KMG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

767817:DESGI RS03855
gene id: 767817:DESGI_RS03855
uniprot id: R4KCQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

767817:DESGI RS12290
gene id: 767817:DESGI_RS12290
uniprot id: R4KQR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.
messages: Homodimer.

767817:DESGI RS06085
gene id: 767817:DESGI_RS06085
uniprot id: R4KGL0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

767817:DESGI RS09880
gene id: 767817:DESGI_RS09880
uniprot id: R4KPF8
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

767817:DESGI RS02965
gene id: 767817:DESGI_RS02965
uniprot id: R4KI40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

767817:DESGI RS04555
gene id: 767817:DESGI_RS04555
uniprot id: R4KBH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArsB family.
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS19620
gene id: 767817:DESGI_RS19620
uniprot id: R4KUT3
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

767817:DESGI RS06255
gene id: 767817:DESGI_RS06255
uniprot id: R4KMH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

767817:DESGI RS03420
gene id: 767817:DESGI_RS03420
uniprot id: R4KAR3
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

767817:DESGI RS01810
gene id: 767817:DESGI_RS01810
uniprot id: R4KBJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

767817:DESGI RS17130
gene id: 767817:DESGI_RS17130
uniprot id: R4KJX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

767817:DESGI RS22470
gene id: 767817:DESGI_RS22470
uniprot id: R4KWE3
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

767817:DESGI RS11465
gene id: 767817:DESGI_RS11465
uniprot id: R4KMP7
names: Function
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

767817:DESGI RS07270
gene id: 767817:DESGI_RS07270
uniprot id: R4KEM5
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS12405
gene id: 767817:DESGI_RS12405
uniprot id: R4KNA0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS20480
gene id: 767817:DESGI_RS20480
uniprot id: R4KLL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

767817:DESGI RS10845
gene id: 767817:DESGI_RS10845
uniprot id: R4KGH7
names: Similarity
messages: Belongs to the FlgM family.

767817:DESGI RS10035
gene id: 767817:DESGI_RS10035
uniprot id: R4KPI0
names: Subcellular Location Annotation
messages: Mitochondrion

767817:DESGI RS09265
gene id: 767817:DESGI_RS09265
uniprot id: R4KFL8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

767817:DESGI RS09955
gene id: 767817:DESGI_RS09955
uniprot id: R4KPG8
names: Similarity
messages: Belongs to the universal stress protein A family.

767817:DESGI RS17820
gene id: 767817:DESGI_RS17820
uniprot id: R4KKA2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

767817:DESGI RS09630
gene id: 767817:DESGI_RS09630
uniprot id: R4KPA2
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

767817:DESGI RS17175
gene id: 767817:DESGI_RS17175
uniprot id: R4KIA9
names: Similarity
messages: Belongs to the UPF0235 family.

767817:DESGI RS01085
gene id: 767817:DESGI_RS01085
uniprot id: R4KB73
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

767817:DESGI RS00880
gene id: 767817:DESGI_RS00880
uniprot id: R4KGZ0
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

767817:DESGI RS10815
gene id: 767817:DESGI_RS10815
uniprot id: R4KES3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

767817:DESGI RS10075
gene id: 767817:DESGI_RS10075
uniprot id: R4KG42
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

767817:DESGI RS13875
gene id: 767817:DESGI_RS13875
uniprot id: R4KP07
names: Similarity
messages: Belongs to the AOR/FOR family.

767817:DESGI RS09045
gene id: 767817:DESGI_RS09045
uniprot id: R4KFH7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

767817:DESGI RS13380
gene id: 767817:DESGI_RS13380
uniprot id: R4KNS0
names: Similarity
messages: Belongs to the fabD family.

767817:DESGI RS10380
gene id: 767817:DESGI_RS10380
uniprot id: R4KPM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

767817:DESGI RS20220
gene id: 767817:DESGI_RS20220
uniprot id: R4KK07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

767817:DESGI RS10865
gene id: 767817:DESGI_RS10865
uniprot id: R4KET3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

767817:DESGI RS05235
gene id: 767817:DESGI_RS05235
uniprot id: R4KDH8
names: Similarity
messages: Belongs to the AOR/FOR family.

767817:DESGI RS15370
gene id: 767817:DESGI_RS15370
uniprot id: R4KHA6
names: Similarity
messages: Belongs to the thioesterase PaaI family.

767817:DESGI RS14570
gene id: 767817:DESGI_RS14570
uniprot id: R4KII6
names: Function
names: Similarity
names: Subunit
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Homodimer and homohexamer; in equilibrium.
messages: Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.

767817:DESGI RS20415
gene id: 767817:DESGI_RS20415
uniprot id: R4KPU1
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

767817:DESGI RS08930
gene id: 767817:DESGI_RS08930
uniprot id: R4KI64
names: Similarity
messages: Belongs to the AAA ATPase family.
messages: In the C-terminal section; belongs to the peptidase M41 family.

767817:DESGI RS20955
gene id: 767817:DESGI_RS20955
uniprot id: R4KVJ8
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

767817:DESGI RS10165
gene id: 767817:DESGI_RS10165
uniprot id: R4KPJ7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

767817:DESGI RS17280
gene id: 767817:DESGI_RS17280
uniprot id: R4KQU6
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

767817:DESGI RS15745
gene id: 767817:DESGI_RS15745
uniprot id: R4KHG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

767817:DESGI RS08050
gene id: 767817:DESGI_RS08050
uniprot id: R4KHN6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

767817:DESGI RS08645
gene id: 767817:DESGI_RS08645
uniprot id: R4KF98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

767817:DESGI RS10555
gene id: 767817:DESGI_RS10555
uniprot id: R4KPR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

767817:DESGI RS21805
gene id: 767817:DESGI_RS21805
uniprot id: R4KMA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

767817:DESGI RS00790
gene id: 767817:DESGI_RS00790
uniprot id: R4KDK9
names: Similarity
messages: Belongs to the UPF0251 family.

767817:DESGI RS09445
gene id: 767817:DESGI_RS09445
uniprot id: R4KFP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0316 family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS07165
gene id: 767817:DESGI_RS07165
uniprot id: R4KKH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

767817:DESGI RS04160
gene id: 767817:DESGI_RS04160
uniprot id: R4KB70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

767817:DESGI RS09840
gene id: 767817:DESGI_RS09840
uniprot id: R4KEB9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

767817:DESGI RS11190
gene id: 767817:DESGI_RS11190
uniprot id: R4KMJ9
names: Similarity
messages: Belongs to the zinc-associated anti-sigma factor (ZAS) superfamily. Anti-sigma-W factor family.

767817:DESGI RS19120
gene id: 767817:DESGI_RS19120
uniprot id: R4KKW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0053 family.
messages: Membrane

767817:DESGI RS12905
gene id: 767817:DESGI_RS12905
uniprot id: R4KHM1
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

767817:DESGI RS20390
gene id: 767817:DESGI_RS20390
uniprot id: R4KPT7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Requires K(+) for maximal activity.
messages: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.

767817:DESGI RS06030
gene id: 767817:DESGI_RS06030
uniprot id: R4KMC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0073 (Hly-III) family.
messages: Membrane

767817:DESGI RS21470
gene id: 767817:DESGI_RS21470
uniprot id: R4KT23
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

767817:DESGI RS20475
gene id: 767817:DESGI_RS20475
uniprot id: R4KK40
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase family.

767817:DESGI RS14580
gene id: 767817:DESGI_RS14580
uniprot id: R4KS54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. TCR/Tet family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS15580
gene id: 767817:DESGI_RS15580
uniprot id: R4KPX9
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

767817:DESGI RS12225
gene id: 767817:DESGI_RS12225
uniprot id: R4KK37
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

767817:DESGI RS03350
gene id: 767817:DESGI_RS03350
uniprot id: R4KCG3
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

767817:DESGI RS01290
gene id: 767817:DESGI_RS01290
uniprot id: R4KJP9
names: Similarity
messages: Belongs to the xanthine dehydrogenase family.

767817:DESGI RS03870
gene id: 767817:DESGI_RS03870
uniprot id: R4KFC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

767817:DESGI RS12765
gene id: 767817:DESGI_RS12765
uniprot id: R4KNG4
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

767817:DESGI RS20760
gene id: 767817:DESGI_RS20760
uniprot id: R4KK79
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

767817:DESGI RS01785
gene id: 767817:DESGI_RS01785
uniprot id: R4KBI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

767817:DESGI RS20640
gene id: 767817:DESGI_RS20640
uniprot id: R4KPY3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

767817:DESGI RS05985
gene id: 767817:DESGI_RS05985
uniprot id: R4KC61
names: Caution
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS00240
gene id: 767817:DESGI_RS00240
uniprot id: R4K912
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

767817:DESGI RS17815
gene id: 767817:DESGI_RS17815
uniprot id: R4KIP9
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS08495
gene id: 767817:DESGI_RS08495
uniprot id: R4KL37
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

767817:DESGI RS08865
gene id: 767817:DESGI_RS08865
uniprot id: R4KFE3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS02470
gene id: 767817:DESGI_RS02470
uniprot id: R4KHV0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

767817:DESGI RS19780
gene id: 767817:DESGI_RS19780
uniprot id: R4KS48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

767817:DESGI RS22430
gene id: 767817:DESGI_RS22430
uniprot id: R4KL64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

767817:DESGI RS12000
gene id: 767817:DESGI_RS12000
uniprot id: R4KJY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

767817:DESGI RS07375
gene id: 767817:DESGI_RS07375
uniprot id: R4KKL3
names: Similarity
messages: Belongs to the UDPGP type 2 family.

767817:DESGI RS17940
gene id: 767817:DESGI_RS17940
uniprot id: R4KKC0
names: Similarity
messages: Belongs to the TrpF family.

767817:DESGI RS14295
gene id: 767817:DESGI_RS14295
uniprot id: R4KP82
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

767817:DESGI RS09135
gene id: 767817:DESGI_RS09135
uniprot id: R4KDW7
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

767817:DESGI RS08995
gene id: 767817:DESGI_RS08995
uniprot id: R4KFG6
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

767817:DESGI RS11120
gene id: 767817:DESGI_RS11120
uniprot id: R4KJF7
names: Similarity
messages: Belongs to the peptidase C40 family.

767817:DESGI RS22365
gene id: 767817:DESGI_RS22365
uniprot id: R4KTJ4
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

767817:DESGI RS08655
gene id: 767817:DESGI_RS08655
uniprot id: R4KNR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

767817:DESGI RS13370
gene id: 767817:DESGI_RS13370
uniprot id: R4KG53
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

767817:DESGI RS13450
gene id: 767817:DESGI_RS13450
uniprot id: R4KHX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

767817:DESGI RS17115
gene id: 767817:DESGI_RS17115
uniprot id: R4KTI7
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

767817:DESGI RS01880
gene id: 767817:DESGI_RS01880
uniprot id: R4K9Y0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

767817:DESGI RS02720
gene id: 767817:DESGI_RS02720
uniprot id: R4KHZ6
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS02610
gene id: 767817:DESGI_RS02610
uniprot id: R4KC24
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

767817:DESGI RS20170
gene id: 767817:DESGI_RS20170
uniprot id: R4KJX2
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

767817:DESGI RS12270
gene id: 767817:DESGI_RS12270
uniprot id: R4KK44
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

767817:DESGI RS15225
gene id: 767817:DESGI_RS15225
uniprot id: R4KLY4
names: Similarity
messages: Belongs to the serpin family.

767817:DESGI RS17215
gene id: 767817:DESGI_RS17215
uniprot id: R4KTK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

767817:DESGI RS02500
gene id: 767817:DESGI_RS02500
uniprot id: R4KKD4
names: Similarity
messages: Belongs to the AOR/FOR family.

767817:DESGI RS20890
gene id: 767817:DESGI_RS20890
uniprot id: R4KQ28
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

767817:DESGI RS11050
gene id: 767817:DESGI_RS11050
uniprot id: R4KQ16
names: Similarity
messages: Belongs to the Nudix hydrolase family.

767817:DESGI RS02225
gene id: 767817:DESGI_RS02225
uniprot id: R4KK94
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

767817:DESGI RS11955
gene id: 767817:DESGI_RS11955
uniprot id: R4KFF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

767817:DESGI RS19690
gene id: 767817:DESGI_RS19690
uniprot id: R4KS28
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS06650
gene id: 767817:DESGI_RS06650
uniprot id: R4KK33
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

767817:DESGI RS01605
gene id: 767817:DESGI_RS01605
uniprot id: R4KE22
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

767817:DESGI RS22205
gene id: 767817:DESGI_RS22205
uniprot id: R4KTG3
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

767817:DESGI RS01860
gene id: 767817:DESGI_RS01860
uniprot id: R4KBK3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

767817:DESGI RS01705
gene id: 767817:DESGI_RS01705
uniprot id: R4K9U2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

767817:DESGI RS21740
gene id: 767817:DESGI_RS21740
uniprot id: R4KT76
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

767817:DESGI RS10580
gene id: 767817:DESGI_RS10580
uniprot id: R4KPS0
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

767817:DESGI RS04265
gene id: 767817:DESGI_RS04265
uniprot id: R4KCX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

767817:DESGI RS02595
gene id: 767817:DESGI_RS02595
uniprot id: R4KKF2
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

767817:DESGI RS22095
gene id: 767817:DESGI_RS22095
uniprot id: R4KMG3
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

767817:DESGI RS09110
gene id: 767817:DESGI_RS09110
uniprot id: R4KIA5
names: Similarity
messages: Belongs to the Nudix hydrolase family.

767817:DESGI RS06310
gene id: 767817:DESGI_RS06310
uniprot id: R4KCD1
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS01365
gene id: 767817:DESGI_RS01365
uniprot id: R4K9N0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

767817:DESGI RS16170
gene id: 767817:DESGI_RS16170
uniprot id: R4KHQ5
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

767817:DESGI RS13100
gene id: 767817:DESGI_RS13100
uniprot id: R4KHQ3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

767817:DESGI RS02605
gene id: 767817:DESGI_RS02605
uniprot id: R4KAA9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

767817:DESGI RS12870
gene id: 767817:DESGI_RS12870
uniprot id: R4KKJ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

767817:DESGI RS08515
gene id: 767817:DESGI_RS08515
uniprot id: R4KF74
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

767817:DESGI RS22400
gene id: 767817:DESGI_RS22400
uniprot id: R4KQV6
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS11640
gene id: 767817:DESGI_RS11640
uniprot id: R4KF92
names: Similarity
names: Subunit
messages: Belongs to the MtrB family.
messages: Oligomer of 11 identical subunits arranged in doughnut-like structure.

767817:DESGI RS14435
gene id: 767817:DESGI_RS14435
uniprot id: R4KLF4
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS11630
gene id: 767817:DESGI_RS11630
uniprot id: R4KQD6
names: Similarity
messages: Belongs to the pyruvate kinase family.
messages: In the C-terminal section; belongs to the PEP-utilizing enzyme family.

767817:DESGI RS25785
gene id: 767817:DESGI_RS25785
uniprot id: R4KQ93
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS21865
gene id: 767817:DESGI_RS21865
uniprot id: R4KW27
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

767817:DESGI RS19095
gene id: 767817:DESGI_RS19095
uniprot id: R4KKW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS02365
gene id: 767817:DESGI_RS02365
uniprot id: R4KKB3
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

767817:DESGI RS10510
gene id: 767817:DESGI_RS10510
uniprot id: R4KJ32
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

767817:DESGI RS19760
gene id: 767817:DESGI_RS19760
uniprot id: R4KUW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

767817:DESGI RS13685
gene id: 767817:DESGI_RS13685
uniprot id: R4KL09
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

767817:DESGI RS12770
gene id: 767817:DESGI_RS12770
uniprot id: R4KR35
names: Similarity
messages: Belongs to the transpeptidase family.

767817:DESGI RS19115
gene id: 767817:DESGI_RS19115
uniprot id: R4KJB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS06555
gene id: 767817:DESGI_RS06555
uniprot id: R4KMM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS20100
gene id: 767817:DESGI_RS20100
uniprot id: R4KV36
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

767817:DESGI RS20970
gene id: 767817:DESGI_RS20970
uniprot id: R4KLU0
names: Similarity
messages: Belongs to the peptidase S14 family.

767817:DESGI RS22260
gene id: 767817:DESGI_RS22260
uniprot id: R4KL31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

767817:DESGI RS11410
gene id: 767817:DESGI_RS11410
uniprot id: R4KMN9
names: Similarity
messages: Belongs to the peptidase C40 family.

767817:DESGI RS02795
gene id: 767817:DESGI_RS02795
uniprot id: R4KC57
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

767817:DESGI RS15535
gene id: 767817:DESGI_RS15535
uniprot id: R4KJ24
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

767817:DESGI RS13355
gene id: 767817:DESGI_RS13355
uniprot id: R4KNR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

767817:DESGI RS01480
gene id: 767817:DESGI_RS01480
uniprot id: R4KH76
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS05855
gene id: 767817:DESGI_RS05855
uniprot id: R4KDU2
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS01735
gene id: 767817:DESGI_RS01735
uniprot id: R4KBH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

767817:DESGI RS05675
gene id: 767817:DESGI_RS05675
uniprot id: R4KJL9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

767817:DESGI RS08795
gene id: 767817:DESGI_RS08795
uniprot id: R4KFC7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

767817:DESGI RS04260
gene id: 767817:DESGI_RS04260
uniprot id: R4KB91
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

767817:DESGI RS19645
gene id: 767817:DESGI_RS19645
uniprot id: R4KUT7
names: Similarity
messages: Belongs to the TrpF family.

767817:DESGI RS13590
gene id: 767817:DESGI_RS13590
uniprot id: R4KG97
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

767817:DESGI RS07450
gene id: 767817:DESGI_RS07450
uniprot id: R4KEQ2
names: Similarity
messages: Belongs to the manganese catalase family.

767817:DESGI RS16070
gene id: 767817:DESGI_RS16070
uniprot id: R4KHN3
names: Similarity
messages: Belongs to the disproportionating enzyme family.

767817:DESGI RS10545
gene id: 767817:DESGI_RS10545
uniprot id: R4KGC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

767817:DESGI RS08115
gene id: 767817:DESGI_RS08115
uniprot id: R4KDB3
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

767817:DESGI RS12055
gene id: 767817:DESGI_RS12055
uniprot id: R4KFH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

767817:DESGI RS17180
gene id: 767817:DESGI_RS17180
uniprot id: R4KJY0
names: Subcellular Location Annotation
messages: Cytoplasm

767817:DESGI RS12585
gene id: 767817:DESGI_RS12585
uniprot id: R4KR03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

767817:DESGI RS12740
gene id: 767817:DESGI_RS12740
uniprot id: R4KNG1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

767817:DESGI RS05460
gene id: 767817:DESGI_RS05460
uniprot id: R4KJI2
names: Similarity
messages: Belongs to the DtxR/MntR family.

767817:DESGI RS11740
gene id: 767817:DESGI_RS11740
uniprot id: R4KFB4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

767817:DESGI RS11335
gene id: 767817:DESGI_RS11335
uniprot id: R4KGR2
names: Similarity
messages: Belongs to the glutamine synthetase family.

767817:DESGI RS01695
gene id: 767817:DESGI_RS01695
uniprot id: R4KJX4
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

767817:DESGI RS00025
gene id: 767817:DESGI_RS00025
uniprot id: R4KAP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

767817:DESGI RS04155
gene id: 767817:DESGI_RS04155
uniprot id: R4KFI7
names: Similarity
messages: Belongs to the UPRTase family.

767817:DESGI RS14470
gene id: 767817:DESGI_RS14470
uniprot id: R4KIH0
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS12330
gene id: 767817:DESGI_RS12330
uniprot id: R4KN53
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

767817:DESGI RS17600
gene id: 767817:DESGI_RS17600
uniprot id: R4KK70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

767817:DESGI RS04490
gene id: 767817:DESGI_RS04490
uniprot id: R4KIY3
names: Similarity
messages: Belongs to the CAPAB/TerDEXZ family.

767817:DESGI RS00375
gene id: 767817:DESGI_RS00375
uniprot id: R4KDB8
names: Similarity
messages: Belongs to the UxaA family.

767817:DESGI RS20250
gene id: 767817:DESGI_RS20250
uniprot id: R4KLI7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS19800
gene id: 767817:DESGI_RS19800
uniprot id: R4KL83
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

767817:DESGI RS02840
gene id: 767817:DESGI_RS02840
uniprot id: R4KAE5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

767817:DESGI RS01805
gene id: 767817:DESGI_RS01805
uniprot id: R4K9W4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

767817:DESGI RS21830
gene id: 767817:DESGI_RS21830
uniprot id: R4KMA6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

767817:DESGI RS11085
gene id: 767817:DESGI_RS11085
uniprot id: R4KJF1
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

767817:DESGI RS14450
gene id: 767817:DESGI_RS14450
uniprot id: R4KPA1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

767817:DESGI RS01770
gene id: 767817:DESGI_RS01770
uniprot id: R4KJY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

767817:DESGI RS05895
gene id: 767817:DESGI_RS05895
uniprot id: R4KM97
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

767817:DESGI RS17225
gene id: 767817:DESGI_RS17225
uniprot id: R4KIB9
names: Function
messages: Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals.

767817:DESGI RS12060
gene id: 767817:DESGI_RS12060
uniprot id: R4KH43
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

767817:DESGI RS13940
gene id: 767817:DESGI_RS13940
uniprot id: R4KP16
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

767817:DESGI RS22410
gene id: 767817:DESGI_RS22410
uniprot id: R4KMM7
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS05665
gene id: 767817:DESGI_RS05665
uniprot id: R4KC00
names: Function
messages: May be involved in the biosynthesis of molybdopterin.

767817:DESGI RS03275
gene id: 767817:DESGI_RS03275
uniprot id: R4KKT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

767817:DESGI RS16875
gene id: 767817:DESGI_RS16875
uniprot id: R4KJS3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

767817:DESGI RS05525
gene id: 767817:DESGI_RS05525
uniprot id: R4KDN6
names: Similarity
messages: Belongs to the HupF/HypC family.

767817:DESGI RS05970
gene id: 767817:DESGI_RS05970
uniprot id: R4KJR6
names: Similarity
messages: Belongs to the zinc-associated anti-sigma factor (ZAS) superfamily. Anti-sigma-W factor family.

767817:DESGI RS17870
gene id: 767817:DESGI_RS17870
uniprot id: R4KKA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS00310
gene id: 767817:DESGI_RS00310
uniprot id: R4KAU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS19755
gene id: 767817:DESGI_RS19755
uniprot id: R4KS43
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

767817:DESGI RS22030
gene id: 767817:DESGI_RS22030
uniprot id: R4KW63
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS06830
gene id: 767817:DESGI_RS06830
uniprot id: R4KH14
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS21875
gene id: 767817:DESGI_RS21875
uniprot id: R4KKU5
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS17255
gene id: 767817:DESGI_RS17255
uniprot id: R4KJZ2
names: Function
names: Similarity
messages: Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.

767817:DESGI RS01765
gene id: 767817:DESGI_RS01765
uniprot id: R4KHC1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

767817:DESGI RS15795
gene id: 767817:DESGI_RS15795
uniprot id: R4KHH8
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

767817:DESGI RS22185
gene id: 767817:DESGI_RS22185
uniprot id: R4KWA0
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

767817:DESGI RS10135
gene id: 767817:DESGI_RS10135
uniprot id: R4KPJ4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS01815
gene id: 767817:DESGI_RS01815
uniprot id: R4KHD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

767817:DESGI RS14345
gene id: 767817:DESGI_RS14345
uniprot id: R4KS16
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS08485
gene id: 767817:DESGI_RS08485
uniprot id: R4KDH3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

767817:DESGI RS00990
gene id: 767817:DESGI_RS00990
uniprot id: G6IBR4
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

767817:DESGI RS02300
gene id: 767817:DESGI_RS02300
uniprot id: R4KBW8
names: Similarity
messages: Belongs to the AOR/FOR family.

767817:DESGI RS15840
gene id: 767817:DESGI_RS15840
uniprot id: R4KJ82
names: Similarity
messages: Belongs to the EamA transporter family.

767817:DESGI RS00235
gene id: 767817:DESGI_RS00235
uniprot id: R4KD93
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily.
messages: Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2).

767817:DESGI RS20680
gene id: 767817:DESGI_RS20680
uniprot id: R4KSN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

767817:DESGI RS15730
gene id: 767817:DESGI_RS15730
uniprot id: R4KQ07
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

767817:DESGI RS10885
gene id: 767817:DESGI_RS10885
uniprot id: R4KJB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

767817:DESGI RS10560
gene id: 767817:DESGI_RS10560
uniprot id: R4KJ42
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliO/MopB family.
messages: Cell membrane

767817:DESGI RS20910
gene id: 767817:DESGI_RS20910
uniprot id: R4KLT3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

767817:DESGI RS12285
gene id: 767817:DESGI_RS12285
uniprot id: R4KN41
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

767817:DESGI RS10110
gene id: 767817:DESGI_RS10110
uniprot id: R4KPJ0
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

767817:DESGI RS01560
gene id: 767817:DESGI_RS01560
uniprot id: R4K9R8
names: Similarity
messages: Belongs to the CtsR family.

767817:DESGI RS18020
gene id: 767817:DESGI_RS18020
uniprot id: R4KRB9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. AddB/RexB type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of AddA and AddB.
messages: The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddB nuclease domain is not required for chi fragment generation; this subunit has 5' -> 3' nuclease activity.

767817:DESGI RS07405
gene id: 767817:DESGI_RS07405
uniprot id: R4KN61
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

767817:DESGI RS08530
gene id: 767817:DESGI_RS08530
uniprot id: R4KHX4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

767817:DESGI RS17230
gene id: 767817:DESGI_RS17230
uniprot id: R4KJY7
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS22500
gene id: 767817:DESGI_RS22500
uniprot id: R4KQY0
names: Similarity
messages: Belongs to the polysaccharide synthase family.

767817:DESGI RS12975
gene id: 767817:DESGI_RS12975
uniprot id: R4KHN1
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

767817:DESGI RS00520
gene id: 767817:DESGI_RS00520
uniprot id: R4KGS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

767817:DESGI RS20015
gene id: 767817:DESGI_RS20015
uniprot id: R4KS96
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS21710
gene id: 767817:DESGI_RS21710
uniprot id: R4KM84
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

767817:DESGI RS09130
gene id: 767817:DESGI_RS09130
uniprot id: R4KP10
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

767817:DESGI RS05165
gene id: 767817:DESGI_RS05165
uniprot id: R4KLV4
names: Similarity
messages: Belongs to the peptidase S33 family.

767817:DESGI RS05750
gene id: 767817:DESGI_RS05750
uniprot id: R4KDS7
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS20615
gene id: 767817:DESGI_RS20615
uniprot id: R4KPX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

767817:DESGI RS12990
gene id: 767817:DESGI_RS12990
uniprot id: R4KR76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

767817:DESGI RS06610
gene id: 767817:DESGI_RS06610
uniprot id: R4KGW7
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

767817:DESGI RS18225
gene id: 767817:DESGI_RS18225
uniprot id: R4KU57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

767817:DESGI RS18210
gene id: 767817:DESGI_RS18210
uniprot id: R4KIU7
names: Subcellular Location Annotation
messages: Secreted

767817:DESGI RS19470
gene id: 767817:DESGI_RS19470
uniprot id: R4KRZ4
names: Similarity
messages: Belongs to the peptidase C40 family.

767817:DESGI RS19895
gene id: 767817:DESGI_RS19895
uniprot id: R4KS71
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS08415
gene id: 767817:DESGI_RS08415
uniprot id: R4KL23
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

767817:DESGI RS10045
gene id: 767817:DESGI_RS10045
uniprot id: R4KEE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

767817:DESGI RS20010
gene id: 767817:DESGI_RS20010
uniprot id: R4KLC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

767817:DESGI RS09690
gene id: 767817:DESGI_RS09690
uniprot id: R4KE84
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

767817:DESGI RS09995
gene id: 767817:DESGI_RS09995
uniprot id: R4KED9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

767817:DESGI RS00360
gene id: 767817:DESGI_RS00360
uniprot id: R4KAV2
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

767817:DESGI RS19635
gene id: 767817:DESGI_RS19635
uniprot id: R4KL48
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

767817:DESGI RS13850
gene id: 767817:DESGI_RS13850
uniprot id: R4KP04
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

767817:DESGI RS12065
gene id: 767817:DESGI_RS12065
uniprot id: R4KMZ6
names: Similarity
messages: Belongs to the UPF0735 family.

767817:DESGI RS11020
gene id: 767817:DESGI_RS11020
uniprot id: R4KMH1
names: Similarity
messages: Belongs to the AOR/FOR family.

767817:DESGI RS15140
gene id: 767817:DESGI_RS15140
uniprot id: R4KPQ0
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

767817:DESGI RS01895
gene id: 767817:DESGI_RS01895
uniprot id: R4KK10
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

767817:DESGI RS01795
gene id: 767817:DESGI_RS01795
uniprot id: R4KJZ0
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

767817:DESGI RS13830
gene id: 767817:DESGI_RS13830
uniprot id: R4KRQ9
names: Similarity
messages: Belongs to the glutamine synthetase family.

767817:DESGI RS04075
gene id: 767817:DESGI_RS04075
uniprot id: R4KL92
names: Similarity
messages: Belongs to the P(II) protein family.

767817:DESGI RS12170
gene id: 767817:DESGI_RS12170
uniprot id: R4KQP4
names: Function
names: Similarity
names: Subunit
messages: Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization.
messages: Belongs to the HutP family.
messages: Homohexamer.

767817:DESGI RS03885
gene id: 767817:DESGI_RS03885
uniprot id: G6I9T7
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

767817:DESGI RS15855
gene id: 767817:DESGI_RS15855
uniprot id: R4KHJ3
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

767817:DESGI RS20695
gene id: 767817:DESGI_RS20695
uniprot id: R4KK68
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 26 family. TagA/TarA subfamily.
messages: Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid.

767817:DESGI RS07335
gene id: 767817:DESGI_RS07335
uniprot id: R4KHC0
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

767817:DESGI RS03950
gene id: 767817:DESGI_RS03950
uniprot id: R4KFE4
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

767817:DESGI RS20430
gene id: 767817:DESGI_RS20430
uniprot id: R4KSJ7
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

767817:DESGI RS09435
gene id: 767817:DESGI_RS09435
uniprot id: R4KIH5
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

767817:DESGI RS21780
gene id: 767817:DESGI_RS21780
uniprot id: R4KKS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

767817:DESGI RS04045
gene id: 767817:DESGI_RS04045
uniprot id: R4KIN3
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.

767817:DESGI RS10200
gene id: 767817:DESGI_RS10200
uniprot id: R4KEG7
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

767817:DESGI RS12700
gene id: 767817:DESGI_RS12700
uniprot id: R4KKG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

767817:DESGI RS19815
gene id: 767817:DESGI_RS19815
uniprot id: R4KPD3
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas5 family. Subtype I-C/Dvulg subfamily.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

767817:DESGI RS19475
gene id: 767817:DESGI_RS19475
uniprot id: R4KUR1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS10025
gene id: 767817:DESGI_RS10025
uniprot id: R4KG33
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

767817:DESGI RS04375
gene id: 767817:DESGI_RS04375
uniprot id: R4KIV1
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS01930
gene id: 767817:DESGI_RS01930
uniprot id: R4K9Z0
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

767817:DESGI RS10285
gene id: 767817:DESGI_RS10285
uniprot id: R4KG76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CotF family.
messages: Spore coat

767817:DESGI RS01470
gene id: 767817:DESGI_RS01470
uniprot id: R4K9Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

767817:DESGI RS19745
gene id: 767817:DESGI_RS19745
uniprot id: R4KJN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

767817:DESGI RS16500
gene id: 767817:DESGI_RS16500
uniprot id: R4KML8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

767817:DESGI RS01760
gene id: 767817:DESGI_RS01760
uniprot id: R4KBI1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

767817:DESGI RS09735
gene id: 767817:DESGI_RS09735
uniprot id: R4KIN7
names: Similarity
messages: Belongs to the HdrA family.

767817:DESGI RS08725
gene id: 767817:DESGI_RS08725
uniprot id: R4KL79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

767817:DESGI RS20260
gene id: 767817:DESGI_RS20260
uniprot id: R4KSH1
names: Similarity
messages: Belongs to the CdaR family.

767817:DESGI RS14765
gene id: 767817:DESGI_RS14765
uniprot id: R4KS88
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

767817:DESGI RS06290
gene id: 767817:DESGI_RS06290
uniprot id: R4KCC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

767817:DESGI RS13035
gene id: 767817:DESGI_RS13035
uniprot id: R4KR87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family.
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

767817:DESGI RS06605
gene id: 767817:DESGI_RS06605
uniprot id: R4KMN7
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

767817:DESGI RS16015
gene id: 767817:DESGI_RS16015
uniprot id: R4KQ61
names: Similarity
messages: Belongs to the GerABKA family.

767817:DESGI RS00680
gene id: 767817:DESGI_RS00680
uniprot id: R4KJE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

767817:DESGI RS13040
gene id: 767817:DESGI_RS13040
uniprot id: R4KKM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family.
messages: Belongs to the complex I subunit 5 family.
messages: Membrane

767817:DESGI RS14455
gene id: 767817:DESGI_RS14455
uniprot id: R4KS29
names: Function
names: Similarity
messages: Belongs to the alpha/beta-type SASP family.
messages: SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.

767817:DESGI RS02440
gene id: 767817:DESGI_RS02440
uniprot id: R4KBY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.
messages: Membrane

767817:DESGI RS11840
gene id: 767817:DESGI_RS11840
uniprot id: R4KMV5
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS12235
gene id: 767817:DESGI_RS12235
uniprot id: R4KN29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

767817:DESGI RS09845
gene id: 767817:DESGI_RS09845
uniprot id: R4KG03
names: Similarity
messages: Belongs to the Ahb/Nir family.

767817:DESGI RS02890
gene id: 767817:DESGI_RS02890
uniprot id: R4KC74
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

767817:DESGI RS06055
gene id: 767817:DESGI_RS06055
uniprot id: R4KMD0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Interacts with CtaA.
messages: Membrane

767817:DESGI RS08715
gene id: 767817:DESGI_RS08715
uniprot id: R4KI13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

767817:DESGI RS17420
gene id: 767817:DESGI_RS17420
uniprot id: R4KQY1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

767817:DESGI RS16135
gene id: 767817:DESGI_RS16135
uniprot id: R4KT16
names: Similarity
messages: Belongs to the universal stress protein A family.

767817:DESGI RS14285
gene id: 767817:DESGI_RS14285
uniprot id: R4KGQ5
names: Similarity
messages: Belongs to the RemA family.

767817:DESGI RS01905
gene id: 767817:DESGI_RS01905
uniprot id: R4K9Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.

767817:DESGI RS13595
gene id: 767817:DESGI_RS13595
uniprot id: R4KI04
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

767817:DESGI RS09075
gene id: 767817:DESGI_RS09075
uniprot id: R4KLD8
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

767817:DESGI RS04860
gene id: 767817:DESGI_RS04860
uniprot id: R4KJ84
names: Similarity
messages: Belongs to the peptidase S41A family.

767817:DESGI RS04340
gene id: 767817:DESGI_RS04340
uniprot id: R4KCZ0
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

767817:DESGI RS06500
gene id: 767817:DESGI_RS06500
uniprot id: R4KK08
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

767817:DESGI RS08895
gene id: 767817:DESGI_RS08895
uniprot id: R4KLA9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

767817:DESGI RS16495
gene id: 767817:DESGI_RS16495
uniprot id: G6HZG2
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

767817:DESGI RS01780
gene id: 767817:DESGI_RS01780
uniprot id: R4K9V9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

767817:DESGI RS03800
gene id: 767817:DESGI_RS03800
uniprot id: R4KFB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

767817:DESGI RS14775
gene id: 767817:DESGI_RS14775
uniprot id: R4KH00
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Amj family.
messages: Cell membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS22220
gene id: 767817:DESGI_RS22220
uniprot id: R4KMI7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

767817:DESGI RS06840
gene id: 767817:DESGI_RS06840
uniprot id: R4KK63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS17235
gene id: 767817:DESGI_RS17235
uniprot id: R4KQT4
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

767817:DESGI RS12815
gene id: 767817:DESGI_RS12815
uniprot id: R4KNH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

767817:DESGI RS11805
gene id: 767817:DESGI_RS11805
uniprot id: G6HZG2
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

767817:DESGI RS01615
gene id: 767817:DESGI_RS01615
uniprot id: R4KBF6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

767817:DESGI RS13095
gene id: 767817:DESGI_RS13095
uniprot id: R4KFZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS01285
gene id: 767817:DESGI_RS01285
uniprot id: R4KH42
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

767817:DESGI RS09295
gene id: 767817:DESGI_RS09295
uniprot id: R4KLH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

767817:DESGI RS21160
gene id: 767817:DESGI_RS21160
uniprot id: R4KLX0
names: Similarity
messages: Belongs to the Rpn/YhgA-like nuclease family.

767817:DESGI RS06275
gene id: 767817:DESGI_RS06275
uniprot id: R4KJX3
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

767817:DESGI RS12440
gene id: 767817:DESGI_RS12440
uniprot id: R4KKC1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

767817:DESGI RS08980
gene id: 767817:DESGI_RS08980
uniprot id: R4KI77
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

767817:DESGI RS04040
gene id: 767817:DESGI_RS04040
uniprot id: R4KCT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS02735
gene id: 767817:DESGI_RS02735
uniprot id: R4KAC9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

767817:DESGI RS18275
gene id: 767817:DESGI_RS18275
uniprot id: R4KKG7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

767817:DESGI RS20595
gene id: 767817:DESGI_RS20595
uniprot id: R4KPX4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

767817:DESGI RS16350
gene id: 767817:DESGI_RS16350
uniprot id: R4KQD0
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

767817:DESGI RS17585
gene id: 767817:DESGI_RS17585
uniprot id: R4KR45
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

767817:DESGI RS22100
gene id: 767817:DESGI_RS22100
uniprot id: R4KTE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

767817:DESGI RS03480
gene id: 767817:DESGI_RS03480
uniprot id: R4KID3
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS00005
gene id: 767817:DESGI_RS00005
uniprot id: R4KGJ1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

767817:DESGI RS20440
gene id: 767817:DESGI_RS20440
uniprot id: R4KPU6
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

767817:DESGI RS17550
gene id: 767817:DESGI_RS17550
uniprot id: R4KIL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArsB family.
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS02685
gene id: 767817:DESGI_RS02685
uniprot id: R4KAC0
names: Similarity
messages: Belongs to the arsA ATPase family.

767817:DESGI RS11710
gene id: 767817:DESGI_RS11710
uniprot id: R4KJT4
names: Function
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: This protein is a Fe-Mo-cofactor biosynthetic component.

767817:DESGI RS02460
gene id: 767817:DESGI_RS02460
uniprot id: R4KA83
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

767817:DESGI RS11585
gene id: 767817:DESGI_RS11585
uniprot id: R4KJQ9
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS12620
gene id: 767817:DESGI_RS12620
uniprot id: R4KFT7
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

767817:DESGI RS04675
gene id: 767817:DESGI_RS04675
uniprot id: R4KJ56
names: Similarity
messages: Belongs to the P(II) protein family.

767817:DESGI RS06260
gene id: 767817:DESGI_RS06260
uniprot id: R4KGP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

767817:DESGI RS13070
gene id: 767817:DESGI_RS13070
uniprot id: R4KFZ6
names: Function
names: Similarity
messages: Belongs to the complex I 30 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

767817:DESGI RS13320
gene id: 767817:DESGI_RS13320
uniprot id: R4KG44
names: Similarity
messages: Belongs to the GerABKA family.

767817:DESGI RS22595
gene id: 767817:DESGI_RS22595
uniprot id: R4KMR3
names: Similarity
messages: Belongs to the peptidase M18 family.

767817:DESGI RS10505
gene id: 767817:DESGI_RS10505
uniprot id: R4KPQ2
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

767817:DESGI RS09530
gene id: 767817:DESGI_RS09530
uniprot id: R4KP85
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

767817:DESGI RS18915
gene id: 767817:DESGI_RS18915
uniprot id: R4KRR0
names: Similarity
messages: Belongs to the CdaR family.

767817:DESGI RS10820
gene id: 767817:DESGI_RS10820
uniprot id: R4KGH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
messages: Belongs to the FliW family.
messages: Cytoplasm
messages: Interacts with translational regulator CsrA and flagellin(s).

767817:DESGI RS17410
gene id: 767817:DESGI_RS17410
uniprot id: R4KIG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsL family.
messages: Cell membrane
messages: Essential cell division protein.
messages: Membrane

767817:DESGI RS00700
gene id: 767817:DESGI_RS00700
uniprot id: R4KGV7
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

767817:DESGI RS10650
gene id: 767817:DESGI_RS10650
uniprot id: R4KMA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

767817:DESGI RS21650
gene id: 767817:DESGI_RS21650
uniprot id: R4KQG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Membrane

767817:DESGI RS18250
gene id: 767817:DESGI_RS18250
uniprot id: R4KU61
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

767817:DESGI RS12360
gene id: 767817:DESGI_RS12360
uniprot id: R4KQV1
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS14280
gene id: 767817:DESGI_RS14280
uniprot id: R4KLD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

767817:DESGI RS10480
gene id: 767817:DESGI_RS10480
uniprot id: R4KPP8
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Membrane

767817:DESGI RS09670
gene id: 767817:DESGI_RS09670
uniprot id: R4KFU1
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

767817:DESGI RS01275
gene id: 767817:DESGI_RS01275
uniprot id: R4K9K9
names: Caution
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

767817:DESGI RS21900
gene id: 767817:DESGI_RS21900
uniprot id: R4KKV1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

767817:DESGI RS06455
gene id: 767817:DESGI_RS06455
uniprot id: R4KGT8
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.

767817:DESGI RS07095
gene id: 767817:DESGI_RS07095
uniprot id: R4KMX8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS19570
gene id: 767817:DESGI_RS19570
uniprot id: R4KUS4
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

767817:DESGI RS14290
gene id: 767817:DESGI_RS14290
uniprot id: R4KIE1
names: Similarity
messages: Belongs to the YicC/YloC family.

767817:DESGI RS01835
gene id: 767817:DESGI_RS01835
uniprot id: R4KBJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

767817:DESGI RS08880
gene id: 767817:DESGI_RS08880
uniprot id: R4KI54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

767817:DESGI RS02820
gene id: 767817:DESGI_RS02820
uniprot id: R4KC62
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

767817:DESGI RS17540
gene id: 767817:DESGI_RS17540
uniprot id: R4KTU9
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS01005
gene id: 767817:DESGI_RS01005
uniprot id: R4KDP9
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS09860
gene id: 767817:DESGI_RS09860
uniprot id: R4KIS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
messages: Homooctamer.

767817:DESGI RS01625
gene id: 767817:DESGI_RS01625
uniprot id: R4KJW5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

767817:DESGI RS10625
gene id: 767817:DESGI_RS10625
uniprot id: R4KMA5
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

767817:DESGI RS18750
gene id: 767817:DESGI_RS18750
uniprot id: R4KUD0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

767817:DESGI RS19740
gene id: 767817:DESGI_RS19740
uniprot id: R4KPB8
names: Function
names: Similarity
messages: Belongs to the ATPase gamma chain family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

767817:DESGI RS12930
gene id: 767817:DESGI_RS12930
uniprot id: R4KHM4
names: Subcellular Location Annotation
messages: Cell membrane

767817:DESGI RS00300
gene id: 767817:DESGI_RS00300
uniprot id: R4KDA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

767817:DESGI RS18005
gene id: 767817:DESGI_RS18005
uniprot id: R4KNH3
names: Similarity
messages: Belongs to the UPF0173 family.

767817:DESGI RS08045
gene id: 767817:DESGI_RS08045
uniprot id: R4KNF9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

767817:DESGI RS19980
gene id: 767817:DESGI_RS19980
uniprot id: R4KJT6
names: Similarity
messages: Belongs to the peptidase A31 family.

767817:DESGI RS14305
gene id: 767817:DESGI_RS14305
uniprot id: R4KLD6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS13615
gene id: 767817:DESGI_RS13615
uniprot id: R4KGA3
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS11765
gene id: 767817:DESGI_RS11765
uniprot id: R4KFB9
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

767817:DESGI RS17570
gene id: 767817:DESGI_RS17570
uniprot id: R4KN92
names: Similarity
messages: Belongs to the HdrA family.

767817:DESGI RS09520
gene id: 767817:DESGI_RS09520
uniprot id: R4KFR2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

767817:DESGI RS05765
gene id: 767817:DESGI_RS05765
uniprot id: R4KGF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

767817:DESGI RS17440
gene id: 767817:DESGI_RS17440
uniprot id: R4KK30
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

767817:DESGI RS12725
gene id: 767817:DESGI_RS12725
uniprot id: R4KKG5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

767817:DESGI RS10365
gene id: 767817:DESGI_RS10365
uniprot id: R4KEJ2
names: Similarity
messages: Belongs to the thioesterase PaaI family.

767817:DESGI RS06590
gene id: 767817:DESGI_RS06590
uniprot id: R4KCI4
names: Similarity
messages: Belongs to the GerABKC lipoprotein family.

767817:DESGI RS20215
gene id: 767817:DESGI_RS20215
uniprot id: R4KPQ6
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

767817:DESGI RS06135
gene id: 767817:DESGI_RS06135
uniprot id: R4KGL8
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS15040
gene id: 767817:DESGI_RS15040
uniprot id: R4KPN6
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

767817:DESGI RS11685
gene id: 767817:DESGI_RS11685
uniprot id: R4KJT0
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

767817:DESGI RS06080
gene id: 767817:DESGI_RS06080
uniprot id: R4KMD5
names: Similarity
messages: Belongs to the universal stress protein A family.

767817:DESGI RS02885
gene id: 767817:DESGI_RS02885
uniprot id: R4KER9
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

767817:DESGI RS19080
gene id: 767817:DESGI_RS19080
uniprot id: R4KUJ5
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

767817:DESGI RS01850
gene id: 767817:DESGI_RS01850
uniprot id: R4KE70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

767817:DESGI RS19270
gene id: 767817:DESGI_RS19270
uniprot id: R4KUN0
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS17275
gene id: 767817:DESGI_RS17275
uniprot id: R4KJZ7
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

767817:DESGI RS03900
gene id: 767817:DESGI_RS03900
uniprot id: R4KB15
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

767817:DESGI RS06400
gene id: 767817:DESGI_RS06400
uniprot id: R4KMJ7
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS08260
gene id: 767817:DESGI_RS08260
uniprot id: R4KDD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS08330
gene id: 767817:DESGI_RS08330
uniprot id: R4KNK4
names: Similarity
messages: Belongs to the HdrA family.

767817:DESGI RS17095
gene id: 767817:DESGI_RS17095
uniprot id: R4KMX0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

767817:DESGI RS09935
gene id: 767817:DESGI_RS09935
uniprot id: R4KIT3
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS17010
gene id: 767817:DESGI_RS17010
uniprot id: R4KTG5
names: Similarity
messages: Belongs to the transposase 11 family.

767817:DESGI RS11575
gene id: 767817:DESGI_RS11575
uniprot id: R4KMR5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-97 inactivates the nitrogenase reductase and regulates nitrogenase activity.

767817:DESGI RS05440
gene id: 767817:DESGI_RS05440
uniprot id: R4KM07
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

767817:DESGI RS17510
gene id: 767817:DESGI_RS17510
uniprot id: R4KR33
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS09850
gene id: 767817:DESGI_RS09850
uniprot id: R4KLW4
names: Similarity
messages: Belongs to the Ahb/Nir family.

767817:DESGI RS06305
gene id: 767817:DESGI_RS06305
uniprot id: R4KMH9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

767817:DESGI RS21475
gene id: 767817:DESGI_RS21475
uniprot id: R4KVU6
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

767817:DESGI RS15640
gene id: 767817:DESGI_RS15640
uniprot id: R4KM60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

767817:DESGI RS19410
gene id: 767817:DESGI_RS19410
uniprot id: R4KJG0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

767817:DESGI RS12630
gene id: 767817:DESGI_RS12630
uniprot id: R4KNE4
names: Similarity
messages: Belongs to the hexokinase family.

767817:DESGI RS14190
gene id: 767817:DESGI_RS14190
uniprot id: R4KRY3
names: Similarity
messages: Belongs to the Ahb/Nir family.

767817:DESGI RS04055
gene id: 767817:DESGI_RS04055
uniprot id: R4KFG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS22770
gene id: 767817:DESGI_RS22770
uniprot id: R4KB97
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

767817:DESGI RS14810
gene id: 767817:DESGI_RS14810
uniprot id: R4KSA2
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS01825
gene id: 767817:DESGI_RS01825
uniprot id: R4KE65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

767817:DESGI RS09985
gene id: 767817:DESGI_RS09985
uniprot id: R4KPH2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

767817:DESGI RS02315
gene id: 767817:DESGI_RS02315
uniprot id: R4KEG8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

767817:DESGI RS18290
gene id: 767817:DESGI_RS18290
uniprot id: R4KNL7
names: Similarity
messages: Belongs to the AOR/FOR family.

767817:DESGI RS07655
gene id: 767817:DESGI_RS07655
uniprot id: R4KKQ8
names: Similarity
messages: Belongs to the UPF0175 family.

767817:DESGI RS16125
gene id: 767817:DESGI_RS16125
uniprot id: R4KJD9
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

767817:DESGI RS21075
gene id: 767817:DESGI_RS21075
uniprot id: R4KVM0
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS03195
gene id: 767817:DESGI_RS03195
uniprot id: R4KAK8
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

767817:DESGI RS01680
gene id: 767817:DESGI_RS01680
uniprot id: G6I6G2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

767817:DESGI RS05510
gene id: 767817:DESGI_RS05510
uniprot id: R4KJJ0
names: Similarity
messages: Belongs to the peptidase A31 family.

767817:DESGI RS02805
gene id: 767817:DESGI_RS02805
uniprot id: R4KKI8
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

767817:DESGI RS20140
gene id: 767817:DESGI_RS20140
uniprot id: R4KJW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

767817:DESGI RS18480
gene id: 767817:DESGI_RS18480
uniprot id: R4KNQ2
names: Cofactor
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: Binds 1 Mg(2+) ion per subunit.

767817:DESGI RS13170
gene id: 767817:DESGI_RS13170
uniprot id: R4KG14
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS03285
gene id: 767817:DESGI_RS03285
uniprot id: R4KCF0
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS00550
gene id: 767817:DESGI_RS00550
uniprot id: R4KJC1
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS12390
gene id: 767817:DESGI_RS12390
uniprot id: R4KKB1
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

767817:DESGI RS01910
gene id: 767817:DESGI_RS01910
uniprot id: R4KBL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

767817:DESGI RS11110
gene id: 767817:DESGI_RS11110
uniprot id: R4KMI5
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.

767817:DESGI RS22555
gene id: 767817:DESGI_RS22555
uniprot id: R4KWF5
names: Similarity
messages: Belongs to the peptidase S16 family.

767817:DESGI RS08660
gene id: 767817:DESGI_RS08660
uniprot id: R4KI02
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

767817:DESGI RS20650
gene id: 767817:DESGI_RS20650
uniprot id: R4KLP6
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

767817:DESGI RS14050
gene id: 767817:DESGI_RS14050
uniprot id: R4KL76
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS04030
gene id: 767817:DESGI_RS04030
uniprot id: R4KFG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

767817:DESGI RS21795
gene id: 767817:DESGI_RS21795
uniprot id: R4KQJ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS17835
gene id: 767817:DESGI_RS17835
uniprot id: R4KNE1
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

767817:DESGI RS15500
gene id: 767817:DESGI_RS15500
uniprot id: R4KHB9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

767817:DESGI RS08265
gene id: 767817:DESGI_RS08265
uniprot id: R4KF32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS08305
gene id: 767817:DESGI_RS08305
uniprot id: R4KHT3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

767817:DESGI RS20515
gene id: 767817:DESGI_RS20515
uniprot id: R4KVC9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

767817:DESGI RS17310
gene id: 767817:DESGI_RS17310
uniprot id: R4KTN0
names: Similarity
messages: Belongs to the UPF0749 family.

767817:DESGI RS10575
gene id: 767817:DESGI_RS10575
uniprot id: R4KM96
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

767817:DESGI RS13700
gene id: 767817:DESGI_RS13700
uniprot id: R4KNX6
names: Similarity
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.

767817:DESGI RS13580
gene id: 767817:DESGI_RS13580
uniprot id: R4KRK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

767817:DESGI RS15570
gene id: 767817:DESGI_RS15570
uniprot id: R4KHD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS03370
gene id: 767817:DESGI_RS03370
uniprot id: R4KAQ2
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS18770
gene id: 767817:DESGI_RS18770
uniprot id: R4KRN1
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

767817:DESGI RS06740
gene id: 767817:DESGI_RS06740
uniprot id: R4KEA7
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

767817:DESGI RS22525
gene id: 767817:DESGI_RS22525
uniprot id: R4KQY9
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

767817:DESGI RS14720
gene id: 767817:DESGI_RS14720
uniprot id: R4KPE2
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

767817:DESGI RS12255
gene id: 767817:DESGI_RS12255
uniprot id: R4KH82
names: Similarity
messages: Belongs to the GerABKA family.

767817:DESGI RS00585
gene id: 767817:DESGI_RS00585
uniprot id: R4K984
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

767817:DESGI RS06325
gene id: 767817:DESGI_RS06325
uniprot id: R4KMI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArsB family.
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS20240
gene id: 767817:DESGI_RS20240
uniprot id: R4KPR1
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS10445
gene id: 767817:DESGI_RS10445
uniprot id: R4KGA5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

767817:DESGI RS10850
gene id: 767817:DESGI_RS10850
uniprot id: R4KME4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

767817:DESGI RS14150
gene id: 767817:DESGI_RS14150
uniprot id: R4KLA0
names: Similarity
messages: Belongs to the TPP enzyme family.

767817:DESGI RS18305
gene id: 767817:DESGI_RS18305
uniprot id: R4KKH1
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

767817:DESGI RS16795
gene id: 767817:DESGI_RS16795
uniprot id: R4KMS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VirD4/TraG family.
messages: Membrane

767817:DESGI RS11665
gene id: 767817:DESGI_RS11665
uniprot id: R4KF97
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS06265
gene id: 767817:DESGI_RS06265
uniprot id: R4KCC0
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

767817:DESGI RS21815
gene id: 767817:DESGI_RS21815
uniprot id: R4KW17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

767817:DESGI RS03710
gene id: 767817:DESGI_RS03710
uniprot id: R4KIH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

767817:DESGI RS18695
gene id: 767817:DESGI_RS18695
uniprot id: R4KKN5
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

767817:DESGI RS06075
gene id: 767817:DESGI_RS06075
uniprot id: R4KJT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS10530
gene id: 767817:DESGI_RS10530
uniprot id: R4KPQ9
names: Function
names: Similarity
messages: Belongs to the GTP-binding SRP family.
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

767817:DESGI RS04430
gene id: 767817:DESGI_RS04430
uniprot id: R4KFP1
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS09990
gene id: 767817:DESGI_RS09990
uniprot id: R4KIU1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

767817:DESGI RS20675
gene id: 767817:DESGI_RS20675
uniprot id: R4KLQ0
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS06680
gene id: 767817:DESGI_RS06680
uniprot id: R4KMQ4
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

767817:DESGI RS08450
gene id: 767817:DESGI_RS08450
uniprot id: R4KNM4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

767817:DESGI RS11755
gene id: 767817:DESGI_RS11755
uniprot id: R4KQF9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

767817:DESGI RS23175
gene id: 767817:DESGI_RS23175
uniprot id: R4KIB5
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

767817:DESGI RS19105
gene id: 767817:DESGI_RS19105
uniprot id: R4KUK2
names: Subcellular Location Annotation
messages: Periplasm

767817:DESGI RS06395
gene id: 767817:DESGI_RS06395
uniprot id: R4KJZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

767817:DESGI RS11040
gene id: 767817:DESGI_RS11040
uniprot id: R4KGL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Membrane

767817:DESGI RS22230
gene id: 767817:DESGI_RS22230
uniprot id: R4KWA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyl-CoA hydrolase/transferase family.
messages: Coenzyme A-transferase that converts butyrate to butyryl-CoA.
messages: Cytoplasm

767817:DESGI RS17375
gene id: 767817:DESGI_RS17375
uniprot id: R4KQW8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS12715
gene id: 767817:DESGI_RS12715
uniprot id: R4KNF6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

767817:DESGI RS12780
gene id: 767817:DESGI_RS12780
uniprot id: R4KFV6
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

767817:DESGI RS11240
gene id: 767817:DESGI_RS11240
uniprot id: R4KQ56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

767817:DESGI RS07625
gene id: 767817:DESGI_RS07625
uniprot id: R4KKQ3
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

767817:DESGI RS20425
gene id: 767817:DESGI_RS20425
uniprot id: R4KLL1
names: Similarity
messages: Belongs to the sigma-54 factor family.

767817:DESGI RS12920
gene id: 767817:DESGI_RS12920
uniprot id: R4KKK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

767817:DESGI RS21945
gene id: 767817:DESGI_RS21945
uniprot id: R4KKW2
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

767817:DESGI RS12280
gene id: 767817:DESGI_RS12280
uniprot id: R4KH87
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

767817:DESGI RS02780
gene id: 767817:DESGI_RS02780
uniprot id: R4KEP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

767817:DESGI RS02260
gene id: 767817:DESGI_RS02260
uniprot id: R4KK98
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

767817:DESGI RS19090
gene id: 767817:DESGI_RS19090
uniprot id: R4KJA7
names: Similarity
messages: Belongs to the CdaR family.

767817:DESGI RS19830
gene id: 767817:DESGI_RS19830
uniprot id: R4KUY0
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

767817:DESGI RS17120
gene id: 767817:DESGI_RS17120
uniprot id: R4KMX5
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS06315
gene id: 767817:DESGI_RS06315
uniprot id: R4KE29
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flotillin-like FloA family.
messages: Cell membrane
messages: Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.
messages: Homooligomerizes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

767817:DESGI RS21705
gene id: 767817:DESGI_RS21705
uniprot id: R4KKQ6
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS20265
gene id: 767817:DESGI_RS20265
uniprot id: R4KV94
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

767817:DESGI RS18930
gene id: 767817:DESGI_RS18930
uniprot id: R4KJ71
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS03845
gene id: 767817:DESGI_RS03845
uniprot id: R4KFC2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

767817:DESGI RS23390
gene id: 767817:DESGI_RS23390
uniprot id: R4KLA8
names: Similarity
messages: Belongs to the zinc-associated anti-sigma factor (ZAS) superfamily. Anti-sigma-W factor family.

767817:DESGI RS08920
gene id: 767817:DESGI_RS08920
uniprot id: R4KLB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

767817:DESGI RS07755
gene id: 767817:DESGI_RS07755
uniprot id: R4KKS0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

767817:DESGI RS06270
gene id: 767817:DESGI_RS06270
uniprot id: R4KE18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

767817:DESGI RS01960
gene id: 767817:DESGI_RS01960
uniprot id: R4KBM7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

767817:DESGI RS11580
gene id: 767817:DESGI_RS11580
uniprot id: R4KQC4
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

767817:DESGI RS11950
gene id: 767817:DESGI_RS11950
uniprot id: R4KJX9
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

767817:DESGI RS05515
gene id: 767817:DESGI_RS05515
uniprot id: R4KM21
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

767817:DESGI RS20580
gene id: 767817:DESGI_RS20580
uniprot id: R4KLN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

767817:DESGI RS01925
gene id: 767817:DESGI_RS01925
uniprot id: R4KE89
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

767817:DESGI RS05250
gene id: 767817:DESGI_RS05250
uniprot id: R4KG45
names: Similarity
messages: Belongs to the HdrA family.

767817:DESGI RS15945
gene id: 767817:DESGI_RS15945
uniprot id: R4KMB9
names: Similarity
messages: Belongs to the UPF0251 family.

767817:DESGI RS03980
gene id: 767817:DESGI_RS03980
uniprot id: R4KFE9
names: Similarity
messages: Belongs to the UPF0751 family.

767817:DESGI RS14060
gene id: 767817:DESGI_RS14060
uniprot id: R4KI86
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

767817:DESGI RS13155
gene id: 767817:DESGI_RS13155
uniprot id: R4KNN0
names: Similarity
messages: Belongs to the HepT RNase toxin family.

767817:DESGI RS10070
gene id: 767817:DESGI_RS10070
uniprot id: R4KEF0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnC family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).

767817:DESGI RS12460
gene id: 767817:DESGI_RS12460
uniprot id: R4KQY4
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

767817:DESGI RS02195
gene id: 767817:DESGI_RS02195
uniprot id: R4KK89
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

767817:DESGI RS02915
gene id: 767817:DESGI_RS02915
uniprot id: G6I9T7
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

767817:DESGI RS19000
gene id: 767817:DESGI_RS19000
uniprot id: R4KUH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS13000
gene id: 767817:DESGI_RS13000
uniprot id: R4KFY4
names: Similarity
messages: Belongs to the acylphosphatase family.

767817:DESGI RS21025
gene id: 767817:DESGI_RS21025
uniprot id: R4KSU1
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

767817:DESGI RS11495
gene id: 767817:DESGI_RS11495
uniprot id: R4KQA9
names: Similarity
messages: Belongs to the citrate synthase family.

767817:DESGI RS12570
gene id: 767817:DESGI_RS12570
uniprot id: R4KFT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.

767817:DESGI RS15505
gene id: 767817:DESGI_RS15505
uniprot id: R4KJ19
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

767817:DESGI RS08665
gene id: 767817:DESGI_RS08665
uniprot id: R4KDL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

767817:DESGI RS06460
gene id: 767817:DESGI_RS06460
uniprot id: R4KCG2
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

767817:DESGI RS00010
gene id: 767817:DESGI_RS00010
uniprot id: R4KJ21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

767817:DESGI RS17040
gene id: 767817:DESGI_RS17040
uniprot id: R4KMW2
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS03485
gene id: 767817:DESGI_RS03485
uniprot id: R4KKX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

767817:DESGI RS12070
gene id: 767817:DESGI_RS12070
uniprot id: R4KQM0
names: Function
names: Subcellular Location Annotation
messages: ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
messages: Cytoplasm

767817:DESGI RS01600
gene id: 767817:DESGI_RS01600
uniprot id: R4KJW0
names: Similarity
messages: Belongs to the ycf81 family.

767817:DESGI RS03475
gene id: 767817:DESGI_RS03475
uniprot id: R4KCI7
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS05865
gene id: 767817:DESGI_RS05865
uniprot id: R4KM91
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

767817:DESGI RS19825
gene id: 767817:DESGI_RS19825
uniprot id: R4KS57
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

767817:DESGI RS20465
gene id: 767817:DESGI_RS20465
uniprot id: R4KVC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

767817:DESGI RS17970
gene id: 767817:DESGI_RS17970
uniprot id: R4KRB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

767817:DESGI RS07360
gene id: 767817:DESGI_RS07360
uniprot id: R4KHC3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

767817:DESGI RS14220
gene id: 767817:DESGI_RS14220
uniprot id: R4KLB6
names: Similarity
messages: Belongs to the cytochrome c-552 family.

767817:DESGI RS21125
gene id: 767817:DESGI_RS21125
uniprot id: R4KLW5
names: Similarity
messages: Belongs to the Rpn/YhgA-like nuclease family.

767817:DESGI RS21955
gene id: 767817:DESGI_RS21955
uniprot id: R4KTC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

767817:DESGI RS19850
gene id: 767817:DESGI_RS19850
uniprot id: R4KS62
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

767817:DESGI RS02645
gene id: 767817:DESGI_RS02645
uniprot id: G6I9T7
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

767817:DESGI RS10830
gene id: 767817:DESGI_RS10830
uniprot id: R4KPX1
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

767817:DESGI RS12140
gene id: 767817:DESGI_RS12140
uniprot id: R4KN09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

767817:DESGI RS09870
gene id: 767817:DESGI_RS09870
uniprot id: R4KG06
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

767817:DESGI RS14480
gene id: 767817:DESGI_RS14480
uniprot id: R4KS35
names: Similarity
messages: Belongs to the AOR/FOR family.

767817:DESGI RS07240
gene id: 767817:DESGI_RS07240
uniprot id: R4KHB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

767817:DESGI RS18245
gene id: 767817:DESGI_RS18245
uniprot id: R4KRF4
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

767817:DESGI RS06595
gene id: 767817:DESGI_RS06595
uniprot id: R4KE78
names: Similarity
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.

767817:DESGI RS09650
gene id: 767817:DESGI_RS09650
uniprot id: R4KLP1
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

767817:DESGI RS17125
gene id: 767817:DESGI_RS17125
uniprot id: R4KIA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

767817:DESGI RS10100
gene id: 767817:DESGI_RS10100
uniprot id: R4KG46
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

767817:DESGI RS04550
gene id: 767817:DESGI_RS04550
uniprot id: R4KFU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpxP/Spy family.
messages: Periplasm

767817:DESGI RS07765
gene id: 767817:DESGI_RS07765
uniprot id: R4KHI7
names: Similarity
messages: Belongs to the peptidase S41A family.

767817:DESGI RS08680
gene id: 767817:DESGI_RS08680
uniprot id: R4KNR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

767817:DESGI RS07045
gene id: 767817:DESGI_RS07045
uniprot id: R4KKA4
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

767817:DESGI RS23025
gene id: 767817:DESGI_RS23025
uniprot id: R4KLG0
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

767817:DESGI RS04980
gene id: 767817:DESGI_RS04980
uniprot id: R4KLS6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

767817:DESGI RS20055
gene id: 767817:DESGI_RS20055
uniprot id: R4KJV1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

767817:DESGI RS13195
gene id: 767817:DESGI_RS13195
uniprot id: R4KG19
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS21695
gene id: 767817:DESGI_RS21695
uniprot id: R4KVZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

767817:DESGI RS08950
gene id: 767817:DESGI_RS08950
uniprot id: R4KNX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

767817:DESGI RS10485
gene id: 767817:DESGI_RS10485
uniprot id: R4KJ28
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS09345
gene id: 767817:DESGI_RS09345
uniprot id: R4KLH7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

767817:DESGI RS06700
gene id: 767817:DESGI_RS06700
uniprot id: R4KMQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

767817:DESGI RS12130
gene id: 767817:DESGI_RS12130
uniprot id: R4KFJ5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

767817:DESGI RS12895
gene id: 767817:DESGI_RS12895
uniprot id: R4KKJ5
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

767817:DESGI RS13540
gene id: 767817:DESGI_RS13540
uniprot id: R4KG86
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

767817:DESGI RS08640
gene id: 767817:DESGI_RS08640
uniprot id: R4KDK8
names: Similarity
messages: Belongs to the DprA/Smf family.

767817:DESGI RS13350
gene id: 767817:DESGI_RS13350
uniprot id: R4KHV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS12275
gene id: 767817:DESGI_RS12275
uniprot id: R4KFM6
names: Function
names: Similarity
messages: Belongs to the anti-sigma-factor family.
messages: Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.

767817:DESGI RS17380
gene id: 767817:DESGI_RS17380
uniprot id: R4KTP9
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS17290
gene id: 767817:DESGI_RS17290
uniprot id: R4KN11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

767817:DESGI RS08470
gene id: 767817:DESGI_RS08470
uniprot id: R4KL32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

767817:DESGI RS10090
gene id: 767817:DESGI_RS10090
uniprot id: R4KIV9
names: Similarity
messages: Belongs to the UbiD family.

767817:DESGI RS01380
gene id: 767817:DESGI_RS01380
uniprot id: R4KJR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

767817:DESGI RS01955
gene id: 767817:DESGI_RS01955
uniprot id: R4K9Z4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

767817:DESGI RS07785
gene id: 767817:DESGI_RS07785
uniprot id: R4KNB1
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

767817:DESGI RS18550
gene id: 767817:DESGI_RS18550
uniprot id: R4KJ09
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

767817:DESGI RS13325
gene id: 767817:DESGI_RS13325
uniprot id: R4KHU9
names: Similarity
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.

767817:DESGI RS01355
gene id: 767817:DESGI_RS01355
uniprot id: R4KBB7
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

767817:DESGI RS01740
gene id: 767817:DESGI_RS01740
uniprot id: R4KHB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

767817:DESGI RS10150
gene id: 767817:DESGI_RS10150
uniprot id: R4KEF9
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS07125
gene id: 767817:DESGI_RS07125
uniprot id: R4KH88
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

767817:DESGI RS05260
gene id: 767817:DESGI_RS05260
uniprot id: R4KDI3
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

767817:DESGI RS12445
gene id: 767817:DESGI_RS12445
uniprot id: R4KFR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

767817:DESGI RS19985
gene id: 767817:DESGI_RS19985
uniprot id: R4KLC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArsB family.
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS13655
gene id: 767817:DESGI_RS13655
uniprot id: R4KRM2
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

767817:DESGI RS08455
gene id: 767817:DESGI_RS08455
uniprot id: R4KHV9
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

767817:DESGI RS08870
gene id: 767817:DESGI_RS08870
uniprot id: R4KLA5
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.

767817:DESGI RS08480
gene id: 767817:DESGI_RS08480
uniprot id: R4KHW4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

767817:DESGI RS01845
gene id: 767817:DESGI_RS01845
uniprot id: R4KK00
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

767817:DESGI RS01730
gene id: 767817:DESGI_RS01730
uniprot id: R4K9U8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

767817:DESGI RS22040
gene id: 767817:DESGI_RS22040
uniprot id: R4KKY4
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS11925
gene id: 767817:DESGI_RS11925
uniprot id: R4KFF3
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

767817:DESGI RS17020
gene id: 767817:DESGI_RS17020
uniprot id: R4KI78
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

767817:DESGI RS07330
gene id: 767817:DESGI_RS07330
uniprot id: R4KN52
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

767817:DESGI RS08820
gene id: 767817:DESGI_RS08820
uniprot id: R4KL98
names: Similarity
messages: Belongs to the peptidase M16 family.

767817:DESGI RS19775
gene id: 767817:DESGI_RS19775
uniprot id: R4KL78
names: Similarity
messages: Belongs to the ATPase epsilon chain family.

767817:DESGI RS22015
gene id: 767817:DESGI_RS22015
uniprot id: R4KKX9
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

767817:DESGI RS11920
gene id: 767817:DESGI_RS11920
uniprot id: R4KJX5
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

767817:DESGI RS22540
gene id: 767817:DESGI_RS22540
uniprot id: R4KL86
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

767817:DESGI RS13065
gene id: 767817:DESGI_RS13065
uniprot id: R4KKN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

767817:DESGI RS12425
gene id: 767817:DESGI_RS12425
uniprot id: R4KHE3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

767817:DESGI RS02420
gene id: 767817:DESGI_RS02420
uniprot id: R4KHU0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

767817:DESGI RS03290
gene id: 767817:DESGI_RS03290
uniprot id: R4KI94
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

767817:DESGI RS16935
gene id: 767817:DESGI_RS16935
uniprot id: R4KTF3
names: Similarity
messages: Belongs to the GSP E family.

767817:DESGI RS13180
gene id: 767817:DESGI_RS13180
uniprot id: R4KNN5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

767817:DESGI RS15300
gene id: 767817:DESGI_RS15300
uniprot id: R4KPS5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

767817:DESGI RS19680
gene id: 767817:DESGI_RS19680
uniprot id: R4KJL7
names: Subunit
messages: Homodimer.

767817:DESGI RS03180
gene id: 767817:DESGI_RS03180
uniprot id: R4KKR2
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

767817:DESGI RS13330
gene id: 767817:DESGI_RS13330
uniprot id: R4KNR1
names: Similarity
messages: Belongs to the GerABKC lipoprotein family.

767817:DESGI RS05650
gene id: 767817:DESGI_RS05650
uniprot id: R4KJL6
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

767817:DESGI RS09560
gene id: 767817:DESGI_RS09560
uniprot id: R4KE56
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

767817:DESGI RS00870
gene id: 767817:DESGI_RS00870
uniprot id: R4KB45
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

767817:DESGI RS07410
gene id: 767817:DESGI_RS07410
uniprot id: R4KHD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

767817:DESGI RS00085
gene id: 767817:DESGI_RS00085
uniprot id: R4KD64
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS08535
gene id: 767817:DESGI_RS08535
uniprot id: R4KDI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

767817:DESGI RS06720
gene id: 767817:DESGI_RS06720
uniprot id: R4KMR4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

767817:DESGI RS13535
gene id: 767817:DESGI_RS13535
uniprot id: R4KKY0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

767817:DESGI RS09945
gene id: 767817:DESGI_RS09945
uniprot id: R4KG21
names: Similarity
messages: Belongs to the IMPACT family.

767817:DESGI RS22730
gene id: 767817:DESGI_RS22730
uniprot id: R4KJ68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

767817:DESGI RS10915
gene id: 767817:DESGI_RS10915
uniprot id: R4KEU5
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

767817:DESGI RS07435
gene id: 767817:DESGI_RS07435
uniprot id: R4KHD5
names: Similarity
messages: Belongs to the 6-phosphogluconate dehydrogenase family.

767817:DESGI RS01915
gene id: 767817:DESGI_RS01915
uniprot id: R4KHF9
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS17445
gene id: 767817:DESGI_RS17445
uniprot id: R4KQY5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

767817:DESGI RS11690
gene id: 767817:DESGI_RS11690
uniprot id: R4KFA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

767817:DESGI RS12995
gene id: 767817:DESGI_RS12995
uniprot id: R4KKL7
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

767817:DESGI RS12655
gene id: 767817:DESGI_RS12655
uniprot id: R4KHI4
names: Similarity
messages: Belongs to the PrpF family.

767817:DESGI RS15765
gene id: 767817:DESGI_RS15765
uniprot id: R4KM81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SspH family.
messages: Spore core

767817:DESGI RS10010
gene id: 767817:DESGI_RS10010
uniprot id: R4KPH6
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS19940
gene id: 767817:DESGI_RS19940
uniprot id: R4KLB2
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

767817:DESGI RS21425
gene id: 767817:DESGI_RS21425
uniprot id: R4KVT5
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

767817:DESGI RS01920
gene id: 767817:DESGI_RS01920
uniprot id: R4KK16
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS17855
gene id: 767817:DESGI_RS17855
uniprot id: R4KTZ8
names: Similarity
messages: Belongs to the UPF0178 family.

767817:DESGI RS01520
gene id: 767817:DESGI_RS01520
uniprot id: R4K9R3
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

767817:DESGI RS14560
gene id: 767817:DESGI_RS14560
uniprot id: R4KLH8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

767817:DESGI RS01585
gene id: 767817:DESGI_RS01585
uniprot id: R4K9S3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DisA family.
messages: Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
messages: Homooctamer.
messages: Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, DisA pauses at the lesion site. This triggers a cellular response that culminates in a temporary block in sporulation initiation.

767817:DESGI RS03850
gene id: 767817:DESGI_RS03850
uniprot id: R4KB05
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

767817:DESGI RS00220
gene id: 767817:DESGI_RS00220
uniprot id: R4KAS8
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

767817:DESGI RS19945
gene id: 767817:DESGI_RS19945
uniprot id: R4KS80
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS19615
gene id: 767817:DESGI_RS19615
uniprot id: R4KS14
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

767817:DESGI RS19730
gene id: 767817:DESGI_RS19730
uniprot id: R4KS38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS01980
gene id: 767817:DESGI_RS01980
uniprot id: R4K9Z8
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

767817:DESGI RS14905
gene id: 767817:DESGI_RS14905
uniprot id: R4KIP6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

767817:DESGI RS06705
gene id: 767817:DESGI_RS06705
uniprot id: R4KGY8
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

767817:DESGI RS21085
gene id: 767817:DESGI_RS21085
uniprot id: R4KKD2
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

767817:DESGI RS22110
gene id: 767817:DESGI_RS22110
uniprot id: R4KQQ5
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS13140
gene id: 767817:DESGI_RS13140
uniprot id: R4KKP9
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

767817:DESGI RS20500
gene id: 767817:DESGI_RS20500
uniprot id: R4KK43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

767817:DESGI RS08125
gene id: 767817:DESGI_RS08125
uniprot id: R4KKY1
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

767817:DESGI RS00785
gene id: 767817:DESGI_RS00785
uniprot id: R4KJG8
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

767817:DESGI RS18530
gene id: 767817:DESGI_RS18530
uniprot id: R4KRJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

767817:DESGI RS10005
gene id: 767817:DESGI_RS10005
uniprot id: R4KLZ3
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS12865
gene id: 767817:DESGI_RS12865
uniprot id: R4KR51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

767817:DESGI RS11115
gene id: 767817:DESGI_RS11115
uniprot id: G6HZG2
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

767817:DESGI RS20130
gene id: 767817:DESGI_RS20130
uniprot id: R4KV42
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS21770
gene id: 767817:DESGI_RS21770
uniprot id: R4KW07
names: Similarity
messages: Belongs to the zinc-associated anti-sigma factor (ZAS) superfamily. Anti-sigma-W factor family.

767817:DESGI RS09160
gene id: 767817:DESGI_RS09160
uniprot id: R4KDX2
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

767817:DESGI RS01885
gene id: 767817:DESGI_RS01885
uniprot id: R4KBK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

767817:DESGI RS00275
gene id: 767817:DESGI_RS00275
uniprot id: R4K917
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

767817:DESGI RS07630
gene id: 767817:DESGI_RS07630
uniprot id: R4KN88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS21860
gene id: 767817:DESGI_RS21860
uniprot id: R4KTA1
names: Similarity
messages: Belongs to the AOR/FOR family.

767817:DESGI RS02000
gene id: 767817:DESGI_RS02000
uniprot id: R4KEA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0756 family.
messages: Cell membrane

767817:DESGI RS08520
gene id: 767817:DESGI_RS08520
uniprot id: R4KL42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

767817:DESGI RS13080
gene id: 767817:DESGI_RS13080
uniprot id: R4KNL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

767817:DESGI RS12215
gene id: 767817:DESGI_RS12215
uniprot id: R4KN24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

767817:DESGI RS14875
gene id: 767817:DESGI_RS14875
uniprot id: R4KPH7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

767817:DESGI RS02800
gene id: 767817:DESGI_RS02800
uniprot id: R4KI10
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS15610
gene id: 767817:DESGI_RS15610
uniprot id: R4KSQ8
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

767817:DESGI RS11560
gene id: 767817:DESGI_RS11560
uniprot id: R4KJQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

767817:DESGI RS01370
gene id: 767817:DESGI_RS01370
uniprot id: R4KBC2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

767817:DESGI RS11555
gene id: 767817:DESGI_RS11555
uniprot id: R4KQB9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Binds 1 [8Fe-7S] cluster per heterodimer.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

767817:DESGI RS01630
gene id: 767817:DESGI_RS01630
uniprot id: R4KE28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MrnC RNase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.

767817:DESGI RS01500
gene id: 767817:DESGI_RS01500
uniprot id: R4KBE4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

767817:DESGI RS13130
gene id: 767817:DESGI_RS13130
uniprot id: R4KNM7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

767817:DESGI RS16080
gene id: 767817:DESGI_RS16080
uniprot id: R4KQ75
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

767817:DESGI RS22635
gene id: 767817:DESGI_RS22635
uniprot id: R4KR10
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS07460
gene id: 767817:DESGI_RS07460
uniprot id: R4KN67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

767817:DESGI RS21725
gene id: 767817:DESGI_RS21725
uniprot id: R4KQH7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

767817:DESGI RS10060
gene id: 767817:DESGI_RS10060
uniprot id: R4KPI3
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS22580
gene id: 767817:DESGI_RS22580
uniprot id: R4KWF9
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

767817:DESGI RS13990
gene id: 767817:DESGI_RS13990
uniprot id: R4KGH9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

767817:DESGI RS15490
gene id: 767817:DESGI_RS15490
uniprot id: R4KSN8
names: Similarity
messages: Belongs to the phosphosulfolactate synthase family.

767817:DESGI RS12900
gene id: 767817:DESGI_RS12900
uniprot id: R4KFX2
names: Similarity
messages: Belongs to the RecJ family.

767817:DESGI RS17685
gene id: 767817:DESGI_RS17685
uniprot id: R4KTX2
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

767817:DESGI RS07185
gene id: 767817:DESGI_RS07185
uniprot id: R4KCX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

767817:DESGI RS02375
gene id: 767817:DESGI_RS02375
uniprot id: R4KEH6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

767817:DESGI RS09835
gene id: 767817:DESGI_RS09835
uniprot id: R4KIR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

767817:DESGI RS02650
gene id: 767817:DESGI_RS02650
uniprot id: R4KEM1
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

767817:DESGI RS01385
gene id: 767817:DESGI_RS01385
uniprot id: R4KDX4
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

767817:DESGI RS13300
gene id: 767817:DESGI_RS13300
uniprot id: R4KKS8
names: Similarity
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

767817:DESGI RS12555
gene id: 767817:DESGI_RS12555
uniprot id: R4KNC9
names: Similarity
messages: Belongs to the peptidase U62 family.

767817:DESGI RS19125
gene id: 767817:DESGI_RS19125
uniprot id: R4KRU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0053 family.
messages: Membrane

767817:DESGI RS15800
gene id: 767817:DESGI_RS15800
uniprot id: R4KJ73
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

767817:DESGI RS06190
gene id: 767817:DESGI_RS06190
uniprot id: R4KCA5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

767817:DESGI RS06385
gene id: 767817:DESGI_RS06385
uniprot id: R4KCE6
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

767817:DESGI RS00905
gene id: 767817:DESGI_RS00905
uniprot id: G6IBR4
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

767817:DESGI RS07055
gene id: 767817:DESGI_RS07055
uniprot id: R4KCT3
names: Similarity
messages: Belongs to the GerABKC lipoprotein family.

767817:DESGI RS08625
gene id: 767817:DESGI_RS08625
uniprot id: R4KL60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic Ku family.
messages: Homodimer. Interacts with LigD.
messages: With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.

767817:DESGI RS01875
gene id: 767817:DESGI_RS01875
uniprot id: R4KE76
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

767817:DESGI RS09310
gene id: 767817:DESGI_RS09310
uniprot id: R4KE03
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

767817:DESGI RS13395
gene id: 767817:DESGI_RS13395
uniprot id: R4KG56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

767817:DESGI RS05965
gene id: 767817:DESGI_RS05965
uniprot id: R4KDW1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

767817:DESGI RS13305
gene id: 767817:DESGI_RS13305
uniprot id: R4KG40
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

767817:DESGI RS12050
gene id: 767817:DESGI_RS12050
uniprot id: R4KJZ8
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.

767817:DESGI RS17425
gene id: 767817:DESGI_RS17425
uniprot id: R4KTR2
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

767817:DESGI RS23165
gene id: 767817:DESGI_RS23165
uniprot id: R4KGJ0
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS11265
gene id: 767817:DESGI_RS11265
uniprot id: R4KQ62
names: Similarity
messages: Belongs to the glutamate synthase family.

767817:DESGI RS01755
gene id: 767817:DESGI_RS01755
uniprot id: R4K9V4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

767817:DESGI RS07595
gene id: 767817:DESGI_RS07595
uniprot id: R4KN83
names: Similarity
messages: Belongs to the Nudix hydrolase family.

767817:DESGI RS13705
gene id: 767817:DESGI_RS13705
uniprot id: R4KRN0
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS23190
gene id: 767817:DESGI_RS23190
uniprot id: R4KPE6
names: Similarity
messages: Belongs to the zinc-associated anti-sigma factor (ZAS) superfamily. Anti-sigma-W factor family.

767817:DESGI RS09240
gene id: 767817:DESGI_RS09240
uniprot id: R4KFL6
names: Similarity
messages: Belongs to the Rpn/YhgA-like nuclease family.

767817:DESGI RS06000
gene id: 767817:DESGI_RS06000
uniprot id: R4KMC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CotF family.
messages: Spore coat

767817:DESGI RS12305
gene id: 767817:DESGI_RS12305
uniprot id: R4KH92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

767817:DESGI RS11375
gene id: 767817:DESGI_RS11375
uniprot id: R4KJL4
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS12080
gene id: 767817:DESGI_RS12080
uniprot id: R4KFI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

767817:DESGI RS01840
gene id: 767817:DESGI_RS01840
uniprot id: R4KHD8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

767817:DESGI RS10570
gene id: 767817:DESGI_RS10570
uniprot id: R4KGC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

767817:DESGI RS00860
gene id: 767817:DESGI_RS00860
uniprot id: R4KDM8
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS04540
gene id: 767817:DESGI_RS04540
uniprot id: R4KJ22
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

767817:DESGI RS10945
gene id: 767817:DESGI_RS10945
uniprot id: R4KGJ6
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS18540
gene id: 767817:DESGI_RS18540
uniprot id: R4KNR0
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

767817:DESGI RS01060
gene id: 767817:DESGI_RS01060
uniprot id: R4KB67
names: Function
names: Similarity
messages: Belongs to the UPF0677 family.
messages: Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.

767817:DESGI RS19085
gene id: 767817:DESGI_RS19085
uniprot id: R4KP06
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

767817:DESGI RS19070
gene id: 767817:DESGI_RS19070
uniprot id: R4KKV8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

767817:DESGI RS05655
gene id: 767817:DESGI_RS05655
uniprot id: R4KM54
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
messages: May be involved in the biosynthesis of molybdopterin.

767817:DESGI RS03095
gene id: 767817:DESGI_RS03095
uniprot id: R4KCB2
names: Similarity
messages: Belongs to the CbbQ/NirQ/NorQ/GpvN family.

767817:DESGI RS00800
gene id: 767817:DESGI_RS00800
uniprot id: R4KB31
names: Similarity
messages: Belongs to the DHPS family.

767817:DESGI RS11130
gene id: 767817:DESGI_RS11130
uniprot id: R4KGM5
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS22650
gene id: 767817:DESGI_RS22650
uniprot id: R4KWG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

767817:DESGI RS21855
gene id: 767817:DESGI_RS21855
uniprot id: R4KMB2
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

767817:DESGI RS12550
gene id: 767817:DESGI_RS12550
uniprot id: R4KHG6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

767817:DESGI RS16105
gene id: 767817:DESGI_RS16105
uniprot id: R4KQ79
names: Similarity
messages: Belongs to the asp23 family.

767817:DESGI RS16700
gene id: 767817:DESGI_RS16700
uniprot id: R4KTA9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

767817:DESGI RS22255
gene id: 767817:DESGI_RS22255
uniprot id: R4KQT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

767817:DESGI RS06285
gene id: 767817:DESGI_RS06285
uniprot id: R4KGP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

767817:DESGI RS06380
gene id: 767817:DESGI_RS06380
uniprot id: R4KGR9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

767817:DESGI RS15495
gene id: 767817:DESGI_RS15495
uniprot id: R4KM33
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0756 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS06280
gene id: 767817:DESGI_RS06280
uniprot id: R4KMH5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

767817:DESGI RS07350
gene id: 767817:DESGI_RS07350
uniprot id: R4KKK9
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

767817:DESGI RS11290
gene id: 767817:DESGI_RS11290
uniprot id: R4KQ67
names: Similarity
messages: Belongs to the asparagine synthetase family.

767817:DESGI RS05660
gene id: 767817:DESGI_RS05660
uniprot id: R4KGC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

767817:DESGI RS11900
gene id: 767817:DESGI_RS11900
uniprot id: R4KFE7
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

767817:DESGI RS00770
gene id: 767817:DESGI_RS00770
uniprot id: R4K9C5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

767817:DESGI RS11720
gene id: 767817:DESGI_RS11720
uniprot id: R4KGY4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

767817:DESGI RS13135
gene id: 767817:DESGI_RS13135
uniprot id: R4KRA9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

767817:DESGI RS08915
gene id: 767817:DESGI_RS08915
uniprot id: R4KFF2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
messages: Cytoplasm

767817:DESGI RS08590
gene id: 767817:DESGI_RS08590
uniprot id: R4KDJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

767817:DESGI RS13115
gene id: 767817:DESGI_RS13115
uniprot id: R4KKP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

767817:DESGI RS10615
gene id: 767817:DESGI_RS10615
uniprot id: R4KEN4
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Membrane

767817:DESGI RS12720
gene id: 767817:DESGI_RS12720
uniprot id: R4KR26
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

767817:DESGI RS07495
gene id: 767817:DESGI_RS07495
uniprot id: R4KHE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0060 family.
messages: Cell membrane

767817:DESGI RS12455
gene id: 767817:DESGI_RS12455
uniprot id: R4KNB0
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

767817:DESGI RS03035
gene id: 767817:DESGI_RS03035
uniprot id: R4KEU9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

767817:DESGI RS17475
gene id: 767817:DESGI_RS17475
uniprot id: R4KIK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS08675
gene id: 767817:DESGI_RS08675
uniprot id: R4KL70
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

767817:DESGI RS19880
gene id: 767817:DESGI_RS19880
uniprot id: R4KUZ2
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

767817:DESGI RS03540
gene id: 767817:DESGI_RS03540
uniprot id: R4KF57
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS14315
gene id: 767817:DESGI_RS14315
uniprot id: R4KIE6
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.

767817:DESGI RS15190
gene id: 767817:DESGI_RS15190
uniprot id: R4KSJ0
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

767817:DESGI RS06165
gene id: 767817:DESGI_RS06165
uniprot id: R4KCA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArsB family.
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS20690
gene id: 767817:DESGI_RS20690
uniprot id: R4KPZ2
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

767817:DESGI RS02010
gene id: 767817:DESGI_RS02010
uniprot id: R4KBP0
names: Similarity
messages: Belongs to the HepT RNase toxin family.

767817:DESGI RS13460
gene id: 767817:DESGI_RS13460
uniprot id: R4KRH9
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Autoproteolytically processed. The inactive tetrameric zymogen termed p46 autoprocesses to a smaller form termed p41, which is active only during spore germination.
messages: Belongs to the peptidase A25 family.
messages: Homotetramer.
messages: Initiates the rapid degradation of small, acid-soluble proteins during spore germination.

767817:DESGI RS03450
gene id: 767817:DESGI_RS03450
uniprot id: R4KCI2
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS02815
gene id: 767817:DESGI_RS02815
uniprot id: R4KAE1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS00560
gene id: 767817:DESGI_RS00560
uniprot id: R4K979
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

767817:DESGI RS19750
gene id: 767817:DESGI_RS19750
uniprot id: R4KL73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

767817:DESGI RS16115
gene id: 767817:DESGI_RS16115
uniprot id: R4KMF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

767817:DESGI RS17205
gene id: 767817:DESGI_RS17205
uniprot id: R4KJY3
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

767817:DESGI RS06735
gene id: 767817:DESGI_RS06735
uniprot id: R4KCL5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

767817:DESGI RS07325
gene id: 767817:DESGI_RS07325
uniprot id: R4KKK4
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS02155
gene id: 767817:DESGI_RS02155
uniprot id: R4KA41
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

767817:DESGI RS20745
gene id: 767817:DESGI_RS20745
uniprot id: R4KSP8
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

767817:DESGI RS12380
gene id: 767817:DESGI_RS12380
uniprot id: R4KN86
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cytoplasm
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS10040
gene id: 767817:DESGI_RS10040
uniprot id: R4KIV0
names: Function
messages: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.

767817:DESGI RS13375
gene id: 767817:DESGI_RS13375
uniprot id: R4KHW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

767817:DESGI RS05630
gene id: 767817:DESGI_RS05630
uniprot id: R4KM49
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

767817:DESGI RS19420
gene id: 767817:DESGI_RS19420
uniprot id: R4KRY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

767817:DESGI RS12835
gene id: 767817:DESGI_RS12835
uniprot id: R4KNH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

767817:DESGI RS00440
gene id: 767817:DESGI_RS00440
uniprot id: R4KGR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

767817:DESGI RS21210
gene id: 767817:DESGI_RS21210
uniprot id: R4KLY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the VapD ribonuclease family.
messages: Cleaves ssRNA, mostly between U:A.
messages: Homodimer.

767817:DESGI RS15680
gene id: 767817:DESGI_RS15680
uniprot id: R4KPZ8
names: Function
names: Similarity
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.

767817:DESGI RS05810
gene id: 767817:DESGI_RS05810
uniprot id: R4KJP5
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

767817:DESGI RS13575
gene id: 767817:DESGI_RS13575
uniprot id: R4KNV5
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

767817:DESGI RS09570
gene id: 767817:DESGI_RS09570
uniprot id: R4KLM4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

767817:DESGI RS22285
gene id: 767817:DESGI_RS22285
uniprot id: R4KL36
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

767817:DESGI RS12150
gene id: 767817:DESGI_RS12150
uniprot id: R4KK19
names: Similarity
messages: Belongs to the prephenate/arogenate dehydrogenase family.

767817:DESGI RS07970
gene id: 767817:DESGI_RS07970
uniprot id: R4KHM2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

767817:DESGI RS09605
gene id: 767817:DESGI_RS09605
uniprot id: R4KP96
names: Similarity
messages: Belongs to the CobH/CbiC family.

767817:DESGI RS13715
gene id: 767817:DESGI_RS13715
uniprot id: R4KGC4
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

767817:DESGI RS08815
gene id: 767817:DESGI_RS08815
uniprot id: R4KFD2
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

767817:DESGI RS14160
gene id: 767817:DESGI_RS14160
uniprot id: R4KIB2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

767817:DESGI RS18825
gene id: 767817:DESGI_RS18825
uniprot id: R4KJ50
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

767817:DESGI RS06105
gene id: 767817:DESGI_RS06105
uniprot id: R4KME1
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

767817:DESGI RS11545
gene id: 767817:DESGI_RS11545
uniprot id: R4KGU9
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

767817:DESGI RS06685
gene id: 767817:DESGI_RS06685
uniprot id: R4KGY2
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

767817:DESGI RS20410
gene id: 767817:DESGI_RS20410
uniprot id: R4KVB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

767817:DESGI RS02040
gene id: 767817:DESGI_RS02040
uniprot id: R4KK69
names: Similarity
messages: Belongs to the PemK/MazF family.

767817:DESGI RS22265
gene id: 767817:DESGI_RS22265
uniprot id: R4KMK0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS13090
gene id: 767817:DESGI_RS13090
uniprot id: R4KKN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

767817:DESGI RS07645
gene id: 767817:DESGI_RS07645
uniprot id: R4KET6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS16950
gene id: 767817:DESGI_RS16950
uniprot id: R4KJT9
names: Similarity
messages: Belongs to the peptidase A24 family.

767817:DESGI RS22630
gene id: 767817:DESGI_RS22630
uniprot id: R4KWG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

767817:DESGI RS05080
gene id: 767817:DESGI_RS05080
uniprot id: R4KLT9
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

767817:DESGI RS11230
gene id: 767817:DESGI_RS11230
uniprot id: R4KGP2
names: Function
names: Similarity
messages: Belongs to the PemK/MazF family.
messages: Toxic component of a type II toxin-antitoxin (TA) system.

767817:DESGI RS15830
gene id: 767817:DESGI_RS15830
uniprot id: R4KM94
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

767817:DESGI RS03525
gene id: 767817:DESGI_RS03525
uniprot id: R4KCJ7
names: Similarity
messages: Belongs to the CinA family.

767817:DESGI RS03150
gene id: 767817:DESGI_RS03150
uniprot id: R4KEU9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

767817:DESGI RS00815
gene id: 767817:DESGI_RS00815
uniprot id: R4KDL6
names: Similarity
messages: Belongs to the ThiD family.

767817:DESGI RS18725
gene id: 767817:DESGI_RS18725
uniprot id: R4KKP0
names: Similarity
messages: Belongs to the peptidase S8 family.

767817:DESGI RS15280
gene id: 767817:DESGI_RS15280
uniprot id: R4KLZ4
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

767817:DESGI RS10630
gene id: 767817:DESGI_RS10630
uniprot id: R4KPT1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

767817:DESGI RS22575
gene id: 767817:DESGI_RS22575
uniprot id: R4KTN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

767817:DESGI RS04130
gene id: 767817:DESGI_RS04130
uniprot id: R4KFI1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

767817:DESGI RS20315
gene id: 767817:DESGI_RS20315
uniprot id: R4KSH8
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS21990
gene id: 767817:DESGI_RS21990
uniprot id: R4KKX3
names: Similarity
messages: Belongs to the HepT RNase toxin family.

767817:DESGI RS17930
gene id: 767817:DESGI_RS17930
uniprot id: R4KNF8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

767817:DESGI RS22560
gene id: 767817:DESGI_RS22560
uniprot id: R4KQZ3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

767817:DESGI RS11730
gene id: 767817:DESGI_RS11730
uniprot id: R4KQF3
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS23445
gene id: 767817:DESGI_RS23445
uniprot id: R4KSW9
names: Similarity
messages: Belongs to the peptidase S8 family.

767817:DESGI RS11195
gene id: 767817:DESGI_RS11195
uniprot id: R4KQ45
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

767817:DESGI RS01745
gene id: 767817:DESGI_RS01745
uniprot id: G6I6G2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

767817:DESGI RS13290
gene id: 767817:DESGI_RS13290
uniprot id: R4KNQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS20420
gene id: 767817:DESGI_RS20420
uniprot id: R4KK36
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

767817:DESGI RS03500
gene id: 767817:DESGI_RS03500
uniprot id: R4KID6
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

767817:DESGI RS20395
gene id: 767817:DESGI_RS20395
uniprot id: R4KK34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

767817:DESGI RS21920
gene id: 767817:DESGI_RS21920
uniprot id: R4KKV7
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

767817:DESGI RS04485
gene id: 767817:DESGI_RS04485
uniprot id: R4KD17
names: Similarity
messages: Belongs to the CAPAB/TerDEXZ family.

767817:DESGI RS08850
gene id: 767817:DESGI_RS08850
uniprot id: R4KNV4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

767817:DESGI RS15835
gene id: 767817:DESGI_RS15835
uniprot id: R4KHI8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

767817:DESGI RS04090
gene id: 767817:DESGI_RS04090
uniprot id: R4KCU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS14555
gene id: 767817:DESGI_RS14555
uniprot id: R4KS50
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

767817:DESGI RS01775
gene id: 767817:DESGI_RS01775
uniprot id: R4KE55
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

767817:DESGI RS10565
gene id: 767817:DESGI_RS10565
uniprot id: R4KEM4
names: Similarity
messages: Belongs to the FliN/MopA/SpaO family.

767817:DESGI RS04665
gene id: 767817:DESGI_RS04665
uniprot id: R4KBJ1
names: Similarity
messages: Belongs to the peptidase S58 family.

767817:DESGI RS19710
gene id: 767817:DESGI_RS19710
uniprot id: R4KL63
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS06140
gene id: 767817:DESGI_RS06140
uniprot id: R4KC92
names: Similarity
names: Subunit
messages: Belongs to the UPF0210 family.
messages: Homodimer.

767817:DESGI RS05530
gene id: 767817:DESGI_RS05530
uniprot id: R4KJJ5
names: Similarity
messages: Belongs to the HypD family.

767817:DESGI RS02525
gene id: 767817:DESGI_RS02525
uniprot id: R4KA96
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

767817:DESGI RS19795
gene id: 767817:DESGI_RS19795
uniprot id: R4KJP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

767817:DESGI RS06670
gene id: 767817:DESGI_RS06670
uniprot id: R4KE94
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

767817:DESGI RS00415
gene id: 767817:DESGI_RS00415
uniprot id: R4KGQ8
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

767817:DESGI RS00665
gene id: 767817:DESGI_RS00665
uniprot id: R4K9A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

767817:DESGI RS11725
gene id: 767817:DESGI_RS11725
uniprot id: R4KMU4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

767817:DESGI RS10550
gene id: 767817:DESGI_RS10550
uniprot id: R4KM92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

767817:DESGI RS23045
gene id: 767817:DESGI_RS23045
uniprot id: R4KEM8
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

767817:DESGI RS13210
gene id: 767817:DESGI_RS13210
uniprot id: R4KRC6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

767817:DESGI RS09010
gene id: 767817:DESGI_RS09010
uniprot id: R4KI84
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

767817:DESGI RS09465
gene id: 767817:DESGI_RS09465
uniprot id: R4KE36
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS13860
gene id: 767817:DESGI_RS13860
uniprot id: R4KRR5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

767817:DESGI RS15805
gene id: 767817:DESGI_RS15805
uniprot id: R4KQ22
names: Similarity
messages: Belongs to the peptidase S16 family.

767817:DESGI RS08760
gene id: 767817:DESGI_RS08760
uniprot id: R4KI25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

767817:DESGI RS13490
gene id: 767817:DESGI_RS13490
uniprot id: R4KKX0
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

767817:DESGI RS10080
gene id: 767817:DESGI_RS10080
uniprot id: R4KM06
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnE family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.

767817:DESGI RS15205
gene id: 767817:DESGI_RS15205
uniprot id: R4KIX7
names: Similarity
messages: Belongs to the RutC family.

767817:DESGI RS09515
gene id: 767817:DESGI_RS09515
uniprot id: R4KE47
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS15670
gene id: 767817:DESGI_RS15670
uniprot id: R4KHE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

767817:DESGI RS14430
gene id: 767817:DESGI_RS14430
uniprot id: R4KS24
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

767817:DESGI RS21800
gene id: 767817:DESGI_RS21800
uniprot id: R4KKS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

767817:DESGI RS03065
gene id: 767817:DESGI_RS03065
uniprot id: R4KAI4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

767817:DESGI RS17170
gene id: 767817:DESGI_RS17170
uniprot id: R4KMY4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

767817:DESGI RS01280
gene id: 767817:DESGI_RS01280
uniprot id: R4KBA1
names: Similarity
messages: Belongs to the xanthine dehydrogenase family.

767817:DESGI RS16325
gene id: 767817:DESGI_RS16325
uniprot id: R4KJH6
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

767817:DESGI RS00580
gene id: 767817:DESGI_RS00580
uniprot id: R4KDG4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS22510
gene id: 767817:DESGI_RS22510
uniprot id: R4KMP6
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

767817:DESGI RS01750
gene id: 767817:DESGI_RS01750
uniprot id: R4KE50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

767817:DESGI RS23340
gene id: 767817:DESGI_RS23340
uniprot id: R4KJ83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CotF family.
messages: Spore coat

767817:DESGI RS21960
gene id: 767817:DESGI_RS21960
uniprot id: R4KW47
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

767817:DESGI RS17105
gene id: 767817:DESGI_RS17105
uniprot id: R4KJW7
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

767817:DESGI RS18795
gene id: 767817:DESGI_RS18795
uniprot id: R4KNV1
names: Similarity
messages: Belongs to the AOR/FOR family.

767817:DESGI RS20025
gene id: 767817:DESGI_RS20025
uniprot id: R4KPI1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

767817:DESGI RS02215
gene id: 767817:DESGI_RS02215
uniprot id: R4KBV9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

767817:DESGI RS08425
gene id: 767817:DESGI_RS08425
uniprot id: R4KNM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

767817:DESGI RS21810
gene id: 767817:DESGI_RS21810
uniprot id: R4KT92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

767817:DESGI RS17875
gene id: 767817:DESGI_RS17875
uniprot id: R4KR92
names: Similarity
messages: Belongs to the UPF0045 family.

767817:DESGI RS05550
gene id: 767817:DESGI_RS05550
uniprot id: R4KDP0
names: Similarity
messages: Belongs to the acylphosphatase family.
messages: Belongs to the carbamoyltransferase HypF family.

767817:DESGI RS04405
gene id: 767817:DESGI_RS04405
uniprot id: R4KLF5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

767817:DESGI RS09830
gene id: 767817:DESGI_RS09830
uniprot id: R4KPF3
names: Similarity
messages: Belongs to the UPF0047 family.

767817:DESGI RS18045
gene id: 767817:DESGI_RS18045
uniprot id: R4KRC4
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

767817:DESGI RS02860
gene id: 767817:DESGI_RS02860
uniprot id: R4KER4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

767817:DESGI RS09250
gene id: 767817:DESGI_RS09250
uniprot id: R4KP32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

767817:DESGI RS02540
gene id: 767817:DESGI_RS02540
uniprot id: R4KAA0
names: Similarity
messages: Belongs to the FPG family.

767817:DESGI RS02550
gene id: 767817:DESGI_RS02550
uniprot id: R4KHW5
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS12220
gene id: 767817:DESGI_RS12220
uniprot id: R4KQQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS01870
gene id: 767817:DESGI_RS01870
uniprot id: R4KK05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

767817:DESGI RS15035
gene id: 767817:DESGI_RS15035
uniprot id: R4KIU6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

767817:DESGI RS12985
gene id: 767817:DESGI_RS12985
uniprot id: R4KNK1
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS04420
gene id: 767817:DESGI_RS04420
uniprot id: R4KD03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

767817:DESGI RS18420
gene id: 767817:DESGI_RS18420
uniprot id: R4KU83
names: Similarity
messages: Belongs to the Rpn/YhgA-like nuclease family.

767817:DESGI RS16165
gene id: 767817:DESGI_RS16165
uniprot id: R4KMG2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Binds 1 Fe(2+) ion per subunit. The iron ion 2 is coordinated via four histidines and one cysteine residue.
messages: Binds 1 Fe(3+) ion per subunit. The iron ion 1 is coordinated via 4 cysteine residues.
messages: Catalyzes the one-electron reduction of superoxide anion radical to hydrogen peroxide at a nonheme ferrous iron center. Plays a fundamental role in case of oxidative stress via its superoxide detoxification activity.

767817:DESGI RS01550
gene id: 767817:DESGI_RS01550
uniprot id: R4KJV0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ApbE family.
messages: Cell inner membrane
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

767817:DESGI RS18970
gene id: 767817:DESGI_RS18970
uniprot id: R4KUH4
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

767817:DESGI RS04085
gene id: 767817:DESGI_RS04085
uniprot id: R4KB53
names: Similarity
messages: Belongs to the glutamine synthetase family.

767817:DESGI RS09000
gene id: 767817:DESGI_RS09000
uniprot id: R4KLC6
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

767817:DESGI RS01790
gene id: 767817:DESGI_RS01790
uniprot id: R4KHC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

767817:DESGI RS21540
gene id: 767817:DESGI_RS21540
uniprot id: R4KKL6
names: Similarity
messages: Belongs to the DNA polymerase type-A family.

767817:DESGI RS20405
gene id: 767817:DESGI_RS20405
uniprot id: R4KSJ3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

767817:DESGI RS03130
gene id: 767817:DESGI_RS03130
uniprot id: R4KKQ2
names: Similarity
messages: Belongs to the CbbQ/NirQ/NorQ/GpvN family.

767817:DESGI RS22190
gene id: 767817:DESGI_RS22190
uniprot id: R4KQR6
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

767817:DESGI RS20490
gene id: 767817:DESGI_RS20490
uniprot id: R4KVC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

767817:DESGI RS19650
gene id: 767817:DESGI_RS19650
uniprot id: R4KP99
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

767817:DESGI RS14540
gene id: 767817:DESGI_RS14540
uniprot id: R4KGV4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

767817:DESGI RS07160
gene id: 767817:DESGI_RS07160
uniprot id: R4KEL1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

767817:DESGI RS15195
gene id: 767817:DESGI_RS15195
uniprot id: R4KLY0
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

767817:DESGI RS21970
gene id: 767817:DESGI_RS21970
uniprot id: R4KMD7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

767817:DESGI RS12085
gene id: 767817:DESGI_RS12085
uniprot id: R4KH47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

767817:DESGI RS18945
gene id: 767817:DESGI_RS18945
uniprot id: R4KUG8
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

767817:DESGI RS05575
gene id: 767817:DESGI_RS05575
uniprot id: R4KDP5
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

767817:DESGI RS02170
gene id: 767817:DESGI_RS02170
uniprot id: R4KK86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

767817:DESGI RS17300
gene id: 767817:DESGI_RS17300
uniprot id: R4KK01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sbp family.
messages: Cell membrane

767817:DESGI RS08030
gene id: 767817:DESGI_RS08030
uniprot id: R4KDA1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

767817:DESGI RS14940
gene id: 767817:DESGI_RS14940
uniprot id: R4KPL3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

767817:DESGI RS14230
gene id: 767817:DESGI_RS14230
uniprot id: R4KIC8
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS01700
gene id: 767817:DESGI_RS01700
uniprot id: R4KE39
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

767817:DESGI RS04755
gene id: 767817:DESGI_RS04755
uniprot id: R4KFX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

767817:DESGI RS17395
gene id: 767817:DESGI_RS17395
uniprot id: R4KK18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

767817:DESGI RS05365
gene id: 767817:DESGI_RS05365
uniprot id: R4KLZ1
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

767817:DESGI RS08435
gene id: 767817:DESGI_RS08435
uniprot id: R4KDG2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

767817:DESGI RS10190
gene id: 767817:DESGI_RS10190
uniprot id: R4KPK1
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

767817:DESGI RS17710
gene id: 767817:DESGI_RS17710
uniprot id: R4KNB8
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

767817:DESGI RS11475
gene id: 767817:DESGI_RS11475
uniprot id: R4KJN7
names: Similarity
messages: Belongs to the CdaR family.

767817:DESGI RS00865
gene id: 767817:DESGI_RS00865
uniprot id: R4K9E7
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

767817:DESGI RS18460
gene id: 767817:DESGI_RS18460
uniprot id: R4KIZ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

767817:DESGI RS11025
gene id: 767817:DESGI_RS11025
uniprot id: R4KQ09
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

767817:DESGI RS19820
gene id: 767817:DESGI_RS19820
uniprot id: R4KJP6
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

767817:DESGI RS01475
gene id: 767817:DESGI_RS01475
uniprot id: R4KBE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

767817:DESGI RS18745
gene id: 767817:DESGI_RS18745
uniprot id: R4KRM5
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

767817:DESGI RS09665
gene id: 767817:DESGI_RS09665
uniprot id: R4KE79
names: Similarity
messages: Belongs to the UPF0145 family.

767817:DESGI RS01890
gene id: 767817:DESGI_RS01890
uniprot id: R4KHF1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

767817:DESGI RS17565
gene id: 767817:DESGI_RS17565
uniprot id: R4KTV3
names: Similarity
messages: Belongs to the HdrA family.

767817:DESGI RS19175
gene id: 767817:DESGI_RS19175
uniprot id: R4KJC6
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS13555
gene id: 767817:DESGI_RS13555
uniprot id: R4KRK0
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS13360
gene id: 767817:DESGI_RS13360
uniprot id: R4KRF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

767817:DESGI RS11895
gene id: 767817:DESGI_RS11895
uniprot id: R4KJW9
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

767817:DESGI RS04985
gene id: 767817:DESGI_RS04985
uniprot id: R4KFZ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS09140
gene id: 767817:DESGI_RS09140
uniprot id: R4KFJ7
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

767817:DESGI RS09330
gene id: 767817:DESGI_RS09330
uniprot id: R4KIF2
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS14565
gene id: 767817:DESGI_RS14565
uniprot id: R4KGV9
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

767817:DESGI RS17065
gene id: 767817:DESGI_RS17065
uniprot id: R4KTH6
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

767817:DESGI RS14195
gene id: 767817:DESGI_RS14195
uniprot id: R4KLB1
names: Similarity
messages: Belongs to the Ahb/Nir family.

767817:DESGI RS17305
gene id: 767817:DESGI_RS17305
uniprot id: R4KQV2
names: Similarity
messages: Belongs to the UPF0749 family.

767817:DESGI RS13510
gene id: 767817:DESGI_RS13510
uniprot id: R4KRJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS02220
gene id: 767817:DESGI_RS02220
uniprot id: R4KHR2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

767817:DESGI RS09705
gene id: 767817:DESGI_RS09705
uniprot id: R4KPB5
names: Similarity
messages: Belongs to the HdrA family.

767817:DESGI RS03360
gene id: 767817:DESGI_RS03360
uniprot id: R4KKV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS02175
gene id: 767817:DESGI_RS02175
uniprot id: R4KEF4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

767817:DESGI RS00450
gene id: 767817:DESGI_RS00450
uniprot id: R4KDD3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

767817:DESGI RS07415
gene id: 767817:DESGI_RS07415
uniprot id: R4KD15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PstS family.
messages: Cell membrane
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

767817:DESGI RS22645
gene id: 767817:DESGI_RS22645
uniprot id: R4KMS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

767817:DESGI RS05430
gene id: 767817:DESGI_RS05430
uniprot id: R4KDL5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

767817:DESGI RS17605
gene id: 767817:DESGI_RS17605
uniprot id: R4KR48
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

767817:DESGI RS11915
gene id: 767817:DESGI_RS11915
uniprot id: R4KQJ0
names: Similarity
messages: Belongs to the SAICAR synthetase family.

767817:DESGI RS22025
gene id: 767817:DESGI_RS22025
uniprot id: R4KTD4
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS06445
gene id: 767817:DESGI_RS06445
uniprot id: R4KJZ9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

767817:DESGI RS08565
gene id: 767817:DESGI_RS08565
uniprot id: R4KDJ0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

767817:DESGI RS12470
gene id: 767817:DESGI_RS12470
uniprot id: R4KFR8
names: Similarity
messages: Belongs to the asp23 family.

767817:DESGI RS06440
gene id: 767817:DESGI_RS06440
uniprot id: R4KE53
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

767817:DESGI RS18060
gene id: 767817:DESGI_RS18060
uniprot id: R4KIS8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

767817:DESGI RS03760
gene id: 767817:DESGI_RS03760
uniprot id: R4KII0
names: Similarity
messages: Belongs to the HdrA family.

767817:DESGI RS12145
gene id: 767817:DESGI_RS12145
uniprot id: R4KQN6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

767817:DESGI RS19720
gene id: 767817:DESGI_RS19720
uniprot id: R4KJM7
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

767817:DESGI RS08940
gene id: 767817:DESGI_RS08940
uniprot id: R4KFF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

767817:DESGI RS07585
gene id: 767817:DESGI_RS07585
uniprot id: R4KES7
names: Similarity
messages: Belongs to the HdrA family.

767817:DESGI RS19715
gene id: 767817:DESGI_RS19715
uniprot id: R4KPB3
names: Similarity
messages: Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.

767817:DESGI RS02835
gene id: 767817:DESGI_RS02835
uniprot id: R4KEQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

767817:DESGI RS03020
gene id: 767817:DESGI_RS03020
uniprot id: R4KC98
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS13365
gene id: 767817:DESGI_RS13365
uniprot id: R4KKU4
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

767817:DESGI RS08720
gene id: 767817:DESGI_RS08720
uniprot id: R4KDM5
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS03550
gene id: 767817:DESGI_RS03550
uniprot id: R4KCK0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

767817:DESGI RS08085
gene id: 767817:DESGI_RS08085
uniprot id: R4KF08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

767817:DESGI RS23420
gene id: 767817:DESGI_RS23420
uniprot id: R4KVA1
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

767817:DESGI RS06675
gene id: 767817:DESGI_RS06675
uniprot id: R4KK35
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

767817:DESGI RS10600
gene id: 767817:DESGI_RS10600
uniprot id: R4KMA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

767817:DESGI RS12005
gene id: 767817:DESGI_RS12005
uniprot id: R4KFG8
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

767817:DESGI RS14070
gene id: 767817:DESGI_RS14070
uniprot id: R4KRV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

767817:DESGI RS11735
gene id: 767817:DESGI_RS11735
uniprot id: R4KJT8
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

767817:DESGI RS00285
gene id: 767817:DESGI_RS00285
uniprot id: R4KGN5
names: Similarity
messages: Belongs to the DEAD box helicase family.

767817:DESGI RS03785
gene id: 767817:DESGI_RS03785
uniprot id: R4KII4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

767817:DESGI RS15820
gene id: 767817:DESGI_RS15820
uniprot id: R4KQ27
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

767817:DESGI RS21765
gene id: 767817:DESGI_RS21765
uniprot id: R4KT81
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

767817:DESGI RS20235
gene id: 767817:DESGI_RS20235
uniprot id: R4KV92
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS11405
gene id: 767817:DESGI_RS11405
uniprot id: R4KF44
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

767817:DESGI RS22600
gene id: 767817:DESGI_RS22600
uniprot id: R4KTP0
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS12795
gene id: 767817:DESGI_RS12795
uniprot id: R4KR40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

767817:DESGI RS19670
gene id: 767817:DESGI_RS19670
uniprot id: R4KUU2
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS12790
gene id: 767817:DESGI_RS12790
uniprot id: R4KNG8
names: Similarity
messages: Belongs to the UPF0473 family.

767817:DESGI RS08555
gene id: 767817:DESGI_RS08555
uniprot id: R4KNP4
names: Subcellular Location Annotation
messages: Membrane

767817:DESGI RS13050
gene id: 767817:DESGI_RS13050
uniprot id: R4KHP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

767817:DESGI RS17190
gene id: 767817:DESGI_RS17190
uniprot id: R4KTK2
names: Similarity
messages: Belongs to the YggT family.

767817:DESGI RS01635
gene id: 767817:DESGI_RS01635
uniprot id: R4K9T2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS15635
gene id: 767817:DESGI_RS15635
uniprot id: R4KSR2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

767817:DESGI RS06875
gene id: 767817:DESGI_RS06875
uniprot id: R4KH24
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

767817:DESGI RS18380
gene id: 767817:DESGI_RS18380
uniprot id: R4KKI7
names: Similarity
messages: Belongs to the type IA topoisomerase family.

767817:DESGI RS17265
gene id: 767817:DESGI_RS17265
uniprot id: R4KTL8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

767817:DESGI RS03140
gene id: 767817:DESGI_RS03140
uniprot id: R4KAJ9
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

767817:DESGI RS21940
gene id: 767817:DESGI_RS21940
uniprot id: R4KQM2
names: Similarity
messages: Belongs to the LacAB/RpiB family.

767817:DESGI RS00900
gene id: 767817:DESGI_RS00900
uniprot id: R4K9F3
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

767817:DESGI RS15960
gene id: 767817:DESGI_RS15960
uniprot id: R4KQ53
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

767817:DESGI RS09370
gene id: 767817:DESGI_RS09370
uniprot id: R4KLI0
names: Similarity
messages: Belongs to the AOR/FOR family.

767817:DESGI RS01710
gene id: 767817:DESGI_RS01710
uniprot id: R4KBH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

767817:DESGI RS22180
gene id: 767817:DESGI_RS22180
uniprot id: R4KTF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

767817:DESGI RS05265
gene id: 767817:DESGI_RS05265
uniprot id: R4KJE9
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

767817:DESGI RS17200
gene id: 767817:DESGI_RS17200
uniprot id: R4KIB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

767817:DESGI RS05535
gene id: 767817:DESGI_RS05535
uniprot id: R4KM25
names: Similarity
messages: Belongs to the HypE family.

767817:DESGI RS11370
gene id: 767817:DESGI_RS11370
uniprot id: R4KQ81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.