765912:THIMO RS05230
gene id: 765912:THIMO_RS05230
uniprot id: L0GV88
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

765912:THIMO RS01295
gene id: 765912:THIMO_RS01295
uniprot id: L0GUU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The M ring is integral to the inner membrane of the cell and may be connected to the flagellar rod via the S ring. The S (supramembrane ring) lies just distal to the M ring. The L and P rings lie in the outer membrane and the periplasmic space, respectively.

765912:THIMO RS08320
gene id: 765912:THIMO_RS08320
uniprot id: L0GXH0
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

765912:THIMO RS11230
gene id: 765912:THIMO_RS11230
uniprot id: L0H0H6
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

765912:THIMO RS03030
gene id: 765912:THIMO_RS03030
uniprot id: L0GRU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

765912:THIMO RS09265
gene id: 765912:THIMO_RS09265
uniprot id: L0GY03
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS02285
gene id: 765912:THIMO_RS02285
uniprot id: L0GVE7
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

765912:THIMO RS08965
gene id: 765912:THIMO_RS08965
uniprot id: L0GZ32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

765912:THIMO RS14275
gene id: 765912:THIMO_RS14275
uniprot id: L0H0V8
names: Function
messages: Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers.

765912:THIMO RS09550
gene id: 765912:THIMO_RS09550
uniprot id: L0GZL2
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

765912:THIMO RS05435
gene id: 765912:THIMO_RS05435
uniprot id: L0GX44
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

765912:THIMO RS18515
gene id: 765912:THIMO_RS18515
uniprot id: L0H338
names: Subcellular Location Annotation
messages: Cell inner membrane

765912:THIMO RS14215
gene id: 765912:THIMO_RS14215
uniprot id: L0H202
names: Function
messages: Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers.

765912:THIMO RS05515
gene id: 765912:THIMO_RS05515
uniprot id: L0GXC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Membrane

765912:THIMO RS00290
gene id: 765912:THIMO_RS00290
uniprot id: L0GU94
names: Function
names: Similarity
messages: Belongs to the MurCDEF family. Mpl subfamily.
messages: Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramate.

765912:THIMO RS06175
gene id: 765912:THIMO_RS06175
uniprot id: L0GW83
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

765912:THIMO RS08625
gene id: 765912:THIMO_RS08625
uniprot id: L0GX77
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueG family.
messages: Binds 2 [4Fe-4S] clusters per monomer.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

765912:THIMO RS05245
gene id: 765912:THIMO_RS05245
uniprot id: L0GX71
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

765912:THIMO RS00880
gene id: 765912:THIMO_RS00880
uniprot id: L0GUL9
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

765912:THIMO RS07980
gene id: 765912:THIMO_RS07980
uniprot id: L0GWV2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

765912:THIMO RS08985
gene id: 765912:THIMO_RS08985
uniprot id: L0GZA8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS1 family.
messages: Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.

765912:THIMO RS08895
gene id: 765912:THIMO_RS08895
uniprot id: L0GXS3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

765912:THIMO RS10450
gene id: 765912:THIMO_RS10450
uniprot id: L0GVX6
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

765912:THIMO RS17235
gene id: 765912:THIMO_RS17235
uniprot id: L0H3N3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

765912:THIMO RS06070
gene id: 765912:THIMO_RS06070
uniprot id: L0GW64
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

765912:THIMO RS06700
gene id: 765912:THIMO_RS06700
uniprot id: L0GXT5
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS02195
gene id: 765912:THIMO_RS02195
uniprot id: L0GU24
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytochrome b560 family.
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers.
messages: The heme is bound between the two transmembrane subunits.

765912:THIMO RS09565
gene id: 765912:THIMO_RS09565
uniprot id: L0GXP7
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

765912:THIMO RS07740
gene id: 765912:THIMO_RS07740
uniprot id: L0GYK7
names: Similarity
messages: Belongs to the RecA family.

765912:THIMO RS08075
gene id: 765912:THIMO_RS08075
uniprot id: L0GYN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

765912:THIMO RS11150
gene id: 765912:THIMO_RS11150
uniprot id: L0GWE4
names: Subcellular Location Annotation
messages: Cell inner membrane

765912:THIMO RS07335
gene id: 765912:THIMO_RS07335
uniprot id: L0GY64
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

765912:THIMO RS15540
gene id: 765912:THIMO_RS15540
uniprot id: L0H2X3
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
messages: Periplasm
messages: The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition.

765912:THIMO RS14310
gene id: 765912:THIMO_RS14310
uniprot id: L0H283
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

765912:THIMO RS13435
gene id: 765912:THIMO_RS13435
uniprot id: L0GZZ5
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS13595
gene id: 765912:THIMO_RS13595
uniprot id: L0H0H5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

765912:THIMO RS12350
gene id: 765912:THIMO_RS12350
uniprot id: L0GZB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.
messages: Cytoplasm
messages: Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity.

765912:THIMO RS11890
gene id: 765912:THIMO_RS11890
uniprot id: L0H0V6
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

765912:THIMO RS15715
gene id: 765912:THIMO_RS15715
uniprot id: L0GZ08
names: Similarity
messages: Belongs to the HesB/IscA family.

765912:THIMO RS02850
gene id: 765912:THIMO_RS02850
uniprot id: L0GRP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

765912:THIMO RS00255
gene id: 765912:THIMO_RS00255
uniprot id: L0GQ94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiJ family.
messages: Cytoplasm
messages: Required for ubiquinone (coenzyme Q) biosynthesis. Binds hydrophobic ubiquinone biosynthetic intermediates via its SCP2 domain and is essential for the stability of the Ubi complex. May constitute a docking platform where Ubi enzymes assemble and access their SCP2-bound polyprenyl substrates.

765912:THIMO RS01425
gene id: 765912:THIMO_RS01425
uniprot id: L0GT36
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

765912:THIMO RS09095
gene id: 765912:THIMO_RS09095
uniprot id: L0GXW6
names: Cofactor
names: Similarity
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.

765912:THIMO RS10710
gene id: 765912:THIMO_RS10710
uniprot id: L0GYT5
names: PTM
messages: Binds 2 heme c groups covalently per subunit.

765912:THIMO RS14390
gene id: 765912:THIMO_RS14390
uniprot id: L0H237
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ChlB/BchB/BchZ family.
messages: Binds 1 [4Fe-4S] cluster per heterodimer. The cluster is bound at the heterodimer interface by residues from both subunits.
messages: Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (BchN-BchB) is the catalytic component of the complex.
messages: Protochlorophyllide reductase is composed of three subunits; BchL, BchN and BchB. Forms a heterotetramer of two BchB and two BchN subunits.

765912:THIMO RS10065
gene id: 765912:THIMO_RS10065
uniprot id: L0GZV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

765912:THIMO RS01565
gene id: 765912:THIMO_RS01565
uniprot id: L0GV68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

765912:THIMO RS13685
gene id: 765912:THIMO_RS13685
uniprot id: L0H1Q7
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

765912:THIMO RS10415
gene id: 765912:THIMO_RS10415
uniprot id: L0GY87
names: Similarity
messages: Belongs to the pyruvate kinase family.

765912:THIMO RS06240
gene id: 765912:THIMO_RS06240
uniprot id: L0GXJ7
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

765912:THIMO RS14425
gene id: 765912:THIMO_RS14425
uniprot id: L0H0Y6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

765912:THIMO RS11750
gene id: 765912:THIMO_RS11750
uniprot id: L0H0M8
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

765912:THIMO RS11085
gene id: 765912:THIMO_RS11085
uniprot id: L0GYN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptF/LptG family.
messages: Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).
messages: Membrane
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

765912:THIMO RS16620
gene id: 765912:THIMO_RS16620
uniprot id: L0H288
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space.
messages: In the C-terminal section; belongs to the glycosyl hydrolase 73 family.
messages: In the N-terminal section; belongs to the FlgJ family.
messages: Periplasm

765912:THIMO RS11060
gene id: 765912:THIMO_RS11060
uniprot id: L0GYM9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
messages: Belongs to the helicase family. UvrD subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. Interacts with RecA.
messages: The C-terminal domain has nuclease activity and interacts with RecD. It interacts with RecA, facilitating its loading onto ssDNA.
messages: The N-terminal DNA-binding domain is a ssDNA-dependent ATPase and has ATP-dependent 3'-5' helicase function. This domain interacts with RecC.

765912:THIMO RS02630
gene id: 765912:THIMO_RS02630
uniprot id: L0GTT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

765912:THIMO RS03520
gene id: 765912:THIMO_RS03520
uniprot id: L0GS54
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

765912:THIMO RS13640
gene id: 765912:THIMO_RS13640
uniprot id: L0H027
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

765912:THIMO RS05590
gene id: 765912:THIMO_RS05590
uniprot id: L0GXF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

765912:THIMO RS06010
gene id: 765912:THIMO_RS06010
uniprot id: L0GXM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family. TsaC subfamily.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.

765912:THIMO RS00250
gene id: 765912:THIMO_RS00250
uniprot id: L0GSZ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC1 family. UbiB subfamily.
messages: Cell membrane
messages: Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS00165
gene id: 765912:THIMO_RS00165
uniprot id: L0GU65
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

765912:THIMO RS12080
gene id: 765912:THIMO_RS12080
uniprot id: L0H0Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

765912:THIMO RS01880
gene id: 765912:THIMO_RS01880
uniprot id: L0GTC0
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

765912:THIMO RS07015
gene id: 765912:THIMO_RS07015
uniprot id: L0GW89
names: Similarity
messages: Belongs to the UPF0102 family.

765912:THIMO RS07020
gene id: 765912:THIMO_RS07020
uniprot id: L0GWQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

765912:THIMO RS12935
gene id: 765912:THIMO_RS12935
uniprot id: L0GZM5
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

765912:THIMO RS05420
gene id: 765912:THIMO_RS05420
uniprot id: L0GVS3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

765912:THIMO RS17190
gene id: 765912:THIMO_RS17190
uniprot id: L0H210
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell inner membrane
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

765912:THIMO RS07880
gene id: 765912:THIMO_RS07880
uniprot id: L0GUH4
names: Cofactor
messages: Binds 1 heme c group covalently per subunit.

765912:THIMO RS11690
gene id: 765912:THIMO_RS11690
uniprot id: L0GWP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolA family.
messages: Monomer.
messages: Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
messages: Periplasm

765912:THIMO RS15720
gene id: 765912:THIMO_RS15720
uniprot id: L0H324
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

765912:THIMO RS02035
gene id: 765912:THIMO_RS02035
uniprot id: L0GU00
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

765912:THIMO RS06740
gene id: 765912:THIMO_RS06740
uniprot id: L0GTW1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.
messages: Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin.

765912:THIMO RS14230
gene id: 765912:THIMO_RS14230
uniprot id: L0GY44
names: Function
messages: Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers.

765912:THIMO RS02205
gene id: 765912:THIMO_RS02205
uniprot id: L0GVJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane

765912:THIMO RS00860
gene id: 765912:THIMO_RS00860
uniprot id: L0GSU2
names: Similarity
messages: Belongs to the CutA family.

765912:THIMO RS00340
gene id: 765912:THIMO_RS00340
uniprot id: L0GQA9
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

765912:THIMO RS08005
gene id: 765912:THIMO_RS08005
uniprot id: L0GWV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

765912:THIMO RS15705
gene id: 765912:THIMO_RS15705
uniprot id: L0H1A3
names: Similarity
messages: Belongs to the Nudix hydrolase family.

765912:THIMO RS11955
gene id: 765912:THIMO_RS11955
uniprot id: L0GZ30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

765912:THIMO RS16015
gene id: 765912:THIMO_RS16015
uniprot id: L0H313
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

765912:THIMO RS15975
gene id: 765912:THIMO_RS15975
uniprot id: L0H1W5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
messages: Cell membrane
messages: Heterodimer of a large and a small subunit.

765912:THIMO RS13565
gene id: 765912:THIMO_RS13565
uniprot id: L0H015
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

765912:THIMO RS06335
gene id: 765912:THIMO_RS06335
uniprot id: L0GTN7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

765912:THIMO RS03495
gene id: 765912:THIMO_RS03495
uniprot id: L0GS48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

765912:THIMO RS06330
gene id: 765912:THIMO_RS06330
uniprot id: L0GWB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

765912:THIMO RS07140
gene id: 765912:THIMO_RS07140
uniprot id: L0GY92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

765912:THIMO RS05545
gene id: 765912:THIMO_RS05545
uniprot id: L0GX68
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

765912:THIMO RS14850
gene id: 765912:THIMO_RS14850
uniprot id: L0H2J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

765912:THIMO RS04680
gene id: 765912:THIMO_RS04680
uniprot id: L0GUY5
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS16895
gene id: 765912:THIMO_RS16895
uniprot id: L0GZN3
names: Similarity
messages: Belongs to the CobH/CbiC family.

765912:THIMO RS10200
gene id: 765912:THIMO_RS10200
uniprot id: L0GY38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

765912:THIMO RS05730
gene id: 765912:THIMO_RS05730
uniprot id: L0GW03
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

765912:THIMO RS05045
gene id: 765912:THIMO_RS05045
uniprot id: L0GWW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane

765912:THIMO RS12860
gene id: 765912:THIMO_RS12860
uniprot id: L0GZL0
names: Similarity
messages: Belongs to the transglycosylase Slt family.

765912:THIMO RS11200
gene id: 765912:THIMO_RS11200
uniprot id: L0GWF5
names: Similarity
messages: Belongs to the thioredoxin family.

765912:THIMO RS14110
gene id: 765912:THIMO_RS14110
uniprot id: L0GY20
names: Subcellular Location Annotation
messages: Cytoplasm

765912:THIMO RS10105
gene id: 765912:THIMO_RS10105
uniprot id: L0GYF8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

765912:THIMO RS00920
gene id: 765912:THIMO_RS00920
uniprot id: L0GQQ0
names: Similarity
messages: Belongs to the peptidase S49 family.

765912:THIMO RS05630
gene id: 765912:THIMO_RS05630
uniprot id: L0GVY7
names: Similarity
messages: Belongs to the TrpC family.

765912:THIMO RS03475
gene id: 765912:THIMO_RS03475
uniprot id: L0GW92
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS06965
gene id: 765912:THIMO_RS06965
uniprot id: L0GW79
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

765912:THIMO RS17820
gene id: 765912:THIMO_RS17820
uniprot id: L0H402
names: Similarity
messages: Belongs to the TrbE/VirB4 family.

765912:THIMO RS15115
gene id: 765912:THIMO_RS15115
uniprot id: L0H0W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

765912:THIMO RS15140
gene id: 765912:THIMO_RS15140
uniprot id: L0H0X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

765912:THIMO RS17180
gene id: 765912:THIMO_RS17180
uniprot id: L0H3V7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS01430
gene id: 765912:THIMO_RS01430
uniprot id: L0GTN0
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS00580
gene id: 765912:THIMO_RS00580
uniprot id: L0GSP9
names: Similarity
messages: Belongs to the Dps family.

765912:THIMO RS01100
gene id: 765912:THIMO_RS01100
uniprot id: L0GSY0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

765912:THIMO RS14805
gene id: 765912:THIMO_RS14805
uniprot id: L0H2C2
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS03305
gene id: 765912:THIMO_RS03305
uniprot id: L0GVZ2
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

765912:THIMO RS00845
gene id: 765912:THIMO_RS00845
uniprot id: L0GQN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

765912:THIMO RS05145
gene id: 765912:THIMO_RS05145
uniprot id: L0GWY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

765912:THIMO RS18385
gene id: 765912:THIMO_RS18385
uniprot id: L0GZR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

765912:THIMO RS11940
gene id: 765912:THIMO_RS11940
uniprot id: L0GWT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane
messages: Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.

765912:THIMO RS14060
gene id: 765912:THIMO_RS14060
uniprot id: L0GY12
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

765912:THIMO RS00875
gene id: 765912:THIMO_RS00875
uniprot id: L0GUS8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

765912:THIMO RS17165
gene id: 765912:THIMO_RS17165
uniprot id: L0H205
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

765912:THIMO RS02930
gene id: 765912:THIMO_RS02930
uniprot id: L0GUG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

765912:THIMO RS16065
gene id: 765912:THIMO_RS16065
uniprot id: L0H320
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

765912:THIMO RS16055
gene id: 765912:THIMO_RS16055
uniprot id: L0GZ69
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS02685
gene id: 765912:THIMO_RS02685
uniprot id: L0GUC2
names: Subcellular Location Annotation
messages: Mitochondrion

765912:THIMO RS02745
gene id: 765912:THIMO_RS02745
uniprot id: L0GVU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpoB family.
messages: Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.
messages: Periplasm

765912:THIMO RS06235
gene id: 765912:THIMO_RS06235
uniprot id: L0GXS4
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

765912:THIMO RS04510
gene id: 765912:THIMO_RS04510
uniprot id: L0GWN0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

765912:THIMO RS03260
gene id: 765912:THIMO_RS03260
uniprot id: L0GVY3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

765912:THIMO RS09165
gene id: 765912:THIMO_RS09165
uniprot id: L0GXY1
names: Similarity
messages: Belongs to the XFP family.

765912:THIMO RS11725
gene id: 765912:THIMO_RS11725
uniprot id: L0H0M3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: In the N-terminal section; belongs to the FGAMS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

765912:THIMO RS11080
gene id: 765912:THIMO_RS11080
uniprot id: L0H0A9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

765912:THIMO RS05445
gene id: 765912:THIMO_RS05445
uniprot id: L0GVS8
names: Function
names: Similarity
messages: Belongs to the ribF family.
messages: Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.

765912:THIMO RS17415
gene id: 765912:THIMO_RS17415
uniprot id: L0H2N3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

765912:THIMO RS09910
gene id: 765912:THIMO_RS09910
uniprot id: L0GVN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

765912:THIMO RS11675
gene id: 765912:THIMO_RS11675
uniprot id: L0H0L3
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

765912:THIMO RS14145
gene id: 765912:THIMO_RS14145
uniprot id: L0H1Y6
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS01670
gene id: 765912:THIMO_RS01670
uniprot id: L0GV87
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS15695
gene id: 765912:THIMO_RS15695
uniprot id: L0H321
names: Function
messages: This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.

765912:THIMO RS01370
gene id: 765912:THIMO_RS01370
uniprot id: U3GL00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Cell membrane
messages: Membrane
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

765912:THIMO RS13360
gene id: 765912:THIMO_RS13360
uniprot id: L0H0D4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dsrC/tusE family.
messages: Cytoplasm
messages: Part of a sulfur-relay system.

765912:THIMO RS11620
gene id: 765912:THIMO_RS11620
uniprot id: L0H0Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

765912:THIMO RS08640
gene id: 765912:THIMO_RS08640
uniprot id: L0GZ42
names: Similarity
messages: Belongs to the histone deacetylase family.

765912:THIMO RS15395
gene id: 765912:THIMO_RS15395
uniprot id: L0H2N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

765912:THIMO RS13355
gene id: 765912:THIMO_RS13355
uniprot id: L0GZY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

765912:THIMO RS14935
gene id: 765912:THIMO_RS14935
uniprot id: L0H2E5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

765912:THIMO RS03635
gene id: 765912:THIMO_RS03635
uniprot id: L0GUD4
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

765912:THIMO RS09475
gene id: 765912:THIMO_RS09475
uniprot id: L0GZK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

765912:THIMO RS09230
gene id: 765912:THIMO_RS09230
uniprot id: L0GZ89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

765912:THIMO RS15080
gene id: 765912:THIMO_RS15080
uniprot id: L0GYK0
names: Similarity
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.

765912:THIMO RS12285
gene id: 765912:THIMO_RS12285
uniprot id: L0H130
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

765912:THIMO RS15430
gene id: 765912:THIMO_RS15430
uniprot id: L0H1J6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

765912:THIMO RS09770
gene id: 765912:THIMO_RS09770
uniprot id: L0GY96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

765912:THIMO RS17420
gene id: 765912:THIMO_RS17420
uniprot id: L0GZX9
names: Similarity
messages: Belongs to the Nudix hydrolase family.

765912:THIMO RS00960
gene id: 765912:THIMO_RS00960
uniprot id: L0GSV7
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS10015
gene id: 765912:THIMO_RS10015
uniprot id: L0GZU1
names: Similarity
messages: Belongs to the ClpA/ClpB family.

765912:THIMO RS16700
gene id: 765912:THIMO_RS16700
uniprot id: L0GZJ8
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

765912:THIMO RS02015
gene id: 765912:THIMO_RS02015
uniprot id: L0GTZ6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

765912:THIMO RS13160
gene id: 765912:THIMO_RS13160
uniprot id: L0H1H6
names: Function
names: Similarity
messages: Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1.B.42) family.
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system.

765912:THIMO RS01485
gene id: 765912:THIMO_RS01485
uniprot id: L0GR05
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

765912:THIMO RS09585
gene id: 765912:THIMO_RS09585
uniprot id: L0GZG2
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

765912:THIMO RS04465
gene id: 765912:THIMO_RS04465
uniprot id: L0GVA9
names: Similarity
messages: Belongs to the CFA/CMAS family.

765912:THIMO RS07925
gene id: 765912:THIMO_RS07925
uniprot id: L0GX81
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

765912:THIMO RS17200
gene id: 765912:THIMO_RS17200
uniprot id: L0GZT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

765912:THIMO RS03380
gene id: 765912:THIMO_RS03380
uniprot id: L0GW02
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

765912:THIMO RS06565
gene id: 765912:THIMO_RS06565
uniprot id: L0GXR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PqiA family.
messages: Membrane

765912:THIMO RS08180
gene id: 765912:THIMO_RS08180
uniprot id: L0GX08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

765912:THIMO RS00595
gene id: 765912:THIMO_RS00595
uniprot id: L0GUN2
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

765912:THIMO RS02705
gene id: 765912:THIMO_RS02705
uniprot id: L0GVT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

765912:THIMO RS12275
gene id: 765912:THIMO_RS12275
uniprot id: U3GM67
names: Function
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
messages: Catalyzes the biosynthesis of agmatine from arginine.

765912:THIMO RS07150
gene id: 765912:THIMO_RS07150
uniprot id: L0GWB7
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.

765912:THIMO RS07680
gene id: 765912:THIMO_RS07680
uniprot id: L0GUD7
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

765912:THIMO RS07860
gene id: 765912:THIMO_RS07860
uniprot id: L0GYN0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

765912:THIMO RS05675
gene id: 765912:THIMO_RS05675
uniprot id: L0GXA5
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

765912:THIMO RS06540
gene id: 765912:THIMO_RS06540
uniprot id: L0GXX9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiD family.
messages: Binds 1 prenylated FMN (prenyl-FMN) per subunit.
messages: Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
messages: Cell membrane
messages: Homohexamer.

765912:THIMO RS05070
gene id: 765912:THIMO_RS05070
uniprot id: L0GWX1
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

765912:THIMO RS16635
gene id: 765912:THIMO_RS16635
uniprot id: L0H3C2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

765912:THIMO RS03355
gene id: 765912:THIMO_RS03355
uniprot id: L0GVZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

765912:THIMO RS06915
gene id: 765912:THIMO_RS06915
uniprot id: L0GY50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

765912:THIMO RS00705
gene id: 765912:THIMO_RS00705
uniprot id: L0GSS0
names: Similarity
messages: Belongs to the DsrF/TusC family.

765912:THIMO RS00480
gene id: 765912:THIMO_RS00480
uniprot id: L0GSM7
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

765912:THIMO RS09160
gene id: 765912:THIMO_RS09160
uniprot id: L0GXG1
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

765912:THIMO RS08885
gene id: 765912:THIMO_RS08885
uniprot id: L0GZ15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

765912:THIMO RS05585
gene id: 765912:THIMO_RS05585
uniprot id: L0GT94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

765912:THIMO RS18365
gene id: 765912:THIMO_RS18365
uniprot id: L0H0I0
names: Similarity
messages: Belongs to the peptidase A31 family.

765912:THIMO RS03660
gene id: 765912:THIMO_RS03660
uniprot id: L0GUD8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Monomer.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

765912:THIMO RS12360
gene id: 765912:THIMO_RS12360
uniprot id: L0GX11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

765912:THIMO RS16325
gene id: 765912:THIMO_RS16325
uniprot id: L0H230
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

765912:THIMO RS02575
gene id: 765912:THIMO_RS02575
uniprot id: L0GUA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dsrC/tusE family.
messages: Cytoplasm
messages: Part of a sulfur-relay system.

765912:THIMO RS17260
gene id: 765912:THIMO_RS17260
uniprot id: L0H3N8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

765912:THIMO RS14710
gene id: 765912:THIMO_RS14710
uniprot id: L0H0N1
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

765912:THIMO RS10425
gene id: 765912:THIMO_RS10425
uniprot id: L0GVX1
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

765912:THIMO RS17430
gene id: 765912:THIMO_RS17430
uniprot id: L0H3S3
names: Similarity
messages: Belongs to the peptidase S41A family.

765912:THIMO RS03360
gene id: 765912:THIMO_RS03360
uniprot id: L0GU93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

765912:THIMO RS10615
gene id: 765912:THIMO_RS10615
uniprot id: L0GW24
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

765912:THIMO RS11700
gene id: 765912:THIMO_RS11700
uniprot id: L0H0L8
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

765912:THIMO RS14535
gene id: 765912:THIMO_RS14535
uniprot id: L0GYA0
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

765912:THIMO RS07625
gene id: 765912:THIMO_RS07625
uniprot id: L0GUC9
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

765912:THIMO RS01010
gene id: 765912:THIMO_RS01010
uniprot id: L0GTE9
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

765912:THIMO RS17350
gene id: 765912:THIMO_RS17350
uniprot id: L0GZW6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

765912:THIMO RS03455
gene id: 765912:THIMO_RS03455
uniprot id: L0GW14
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS11435
gene id: 765912:THIMO_RS11435
uniprot id: L0GZ67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

765912:THIMO RS00225
gene id: 765912:THIMO_RS00225
uniprot id: L0GSZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP K family.
messages: Cell inner membrane
messages: Membrane

765912:THIMO RS07000
gene id: 765912:THIMO_RS07000
uniprot id: L0GU10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm

765912:THIMO RS13265
gene id: 765912:THIMO_RS13265
uniprot id: L0GXM0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

765912:THIMO RS13555
gene id: 765912:THIMO_RS13555
uniprot id: L0H1U4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

765912:THIMO RS14280
gene id: 765912:THIMO_RS14280
uniprot id: L0GY54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers.
messages: Belongs to the antenna complex beta subunit family.
messages: Cell inner membrane
messages: Membrane

765912:THIMO RS11515
gene id: 765912:THIMO_RS11515
uniprot id: L0H0N3
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS06195
gene id: 765912:THIMO_RS06195
uniprot id: L0GVU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

765912:THIMO RS06060
gene id: 765912:THIMO_RS06060
uniprot id: L0GXG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

765912:THIMO RS14800
gene id: 765912:THIMO_RS14800
uniprot id: L0H2I5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

765912:THIMO RS09960
gene id: 765912:THIMO_RS09960
uniprot id: L0GVP0
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

765912:THIMO RS11430
gene id: 765912:THIMO_RS11430
uniprot id: L0GYT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

765912:THIMO RS10335
gene id: 765912:THIMO_RS10335
uniprot id: L0GY69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

765912:THIMO RS05970
gene id: 765912:THIMO_RS05970
uniprot id: L0GVQ6
names: Similarity
messages: Belongs to the DprA/Smf family.

765912:THIMO RS15790
gene id: 765912:THIMO_RS15790
uniprot id: L0H1T4
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
messages: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).

765912:THIMO RS07730
gene id: 765912:THIMO_RS07730
uniprot id: L0GX43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. DnaE2 subfamily.
messages: Cytoplasm
messages: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.

765912:THIMO RS09365
gene id: 765912:THIMO_RS09365
uniprot id: L0GY24
names: Function
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.

765912:THIMO RS00410
gene id: 765912:THIMO_RS00410
uniprot id: L0GT41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family. PilQ subfamily.
messages: Cell outer membrane
messages: Membrane

765912:THIMO RS02725
gene id: 765912:THIMO_RS02725
uniprot id: L0GVM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

765912:THIMO RS11710
gene id: 765912:THIMO_RS11710
uniprot id: L0GZC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

765912:THIMO RS07220
gene id: 765912:THIMO_RS07220
uniprot id: L0GYA8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

765912:THIMO RS11360
gene id: 765912:THIMO_RS11360
uniprot id: L0GZ51
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

765912:THIMO RS02955
gene id: 765912:THIMO_RS02955
uniprot id: L0GUI4
names: Similarity
messages: Belongs to the NadC/ModD family.

765912:THIMO RS04380
gene id: 765912:THIMO_RS04380
uniprot id: L0GWK5
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

765912:THIMO RS11535
gene id: 765912:THIMO_RS11535
uniprot id: L0GWL3
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

765912:THIMO RS03470
gene id: 765912:THIMO_RS03470
uniprot id: L0GS43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

765912:THIMO RS05950
gene id: 765912:THIMO_RS05950
uniprot id: L0GW38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

765912:THIMO RS01835
gene id: 765912:THIMO_RS01835
uniprot id: L0GTV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

765912:THIMO RS02075
gene id: 765912:THIMO_RS02075
uniprot id: L0GRB5
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

765912:THIMO RS16160
gene id: 765912:THIMO_RS16160
uniprot id: L0H1H3
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Comprises two domains: an N-terminal domain containing the nucleotidyltransferase activity and a C-terminal HD domain associated with both phosphodiesterase and phosphatase activities.
messages: Magnesium is required for nucleotidyltransferase activity.
messages: Monomer. Can also form homodimers and oligomers.
messages: Nickel for phosphatase activity.

765912:THIMO RS04975
gene id: 765912:THIMO_RS04975
uniprot id: L0GVI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

765912:THIMO RS06585
gene id: 765912:THIMO_RS06585
uniprot id: L0GXY8
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the NapC/NirT/NrfH family.
messages: Binds 4 heme groups per subunit.

765912:THIMO RS00820
gene id: 765912:THIMO_RS00820
uniprot id: L0GUR9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

765912:THIMO RS05255
gene id: 765912:THIMO_RS05255
uniprot id: L0GV94
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS03365
gene id: 765912:THIMO_RS03365
uniprot id: L0GUP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

765912:THIMO RS14415
gene id: 765912:THIMO_RS14415
uniprot id: L0H242
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
messages: Cytoplasm
messages: Monomer.
messages: The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.

765912:THIMO RS14795
gene id: 765912:THIMO_RS14795
uniprot id: L0GYE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

765912:THIMO RS01605
gene id: 765912:THIMO_RS01605
uniprot id: L0GTR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

765912:THIMO RS04620
gene id: 765912:THIMO_RS04620
uniprot id: L0GWW2
names: Similarity
messages: Belongs to the YciI family.

765912:THIMO RS15650
gene id: 765912:THIMO_RS15650
uniprot id: L0H194
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS07425
gene id: 765912:THIMO_RS07425
uniprot id: L0GWX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

765912:THIMO RS17955
gene id: 765912:THIMO_RS17955
uniprot id: L0H2Y8
names: Similarity
messages: Belongs to the UPF0175 family.

765912:THIMO RS00640
gene id: 765912:THIMO_RS00640
uniprot id: L0GQJ9
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

765912:THIMO RS04265
gene id: 765912:THIMO_RS04265
uniprot id: L0GV71
names: Similarity
messages: Belongs to the UPF0145 family.

765912:THIMO RS14225
gene id: 765912:THIMO_RS14225
uniprot id: L0H0U8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers.
messages: Belongs to the antenna complex beta subunit family.
messages: Cell inner membrane
messages: Membrane

765912:THIMO RS13680
gene id: 765912:THIMO_RS13680
uniprot id: L0H1W3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

765912:THIMO RS06925
gene id: 765912:THIMO_RS06925
uniprot id: L0GW67
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

765912:THIMO RS13660
gene id: 765912:THIMO_RS13660
uniprot id: L0H1Q3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

765912:THIMO RS11325
gene id: 765912:THIMO_RS11325
uniprot id: L0H0E6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

765912:THIMO RS01075
gene id: 765912:THIMO_RS01075
uniprot id: L0GSX4
names: Similarity
messages: Belongs to the CmpA/NrtA family.

765912:THIMO RS02945
gene id: 765912:THIMO_RS02945
uniprot id: L0GVR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

765912:THIMO RS16445
gene id: 765912:THIMO_RS16445
uniprot id: L0H382
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

765912:THIMO RS05115
gene id: 765912:THIMO_RS05115
uniprot id: L0GX45
names: Similarity
messages: Belongs to the peptidase S13 family.

765912:THIMO RS03600
gene id: 765912:THIMO_RS03600
uniprot id: L0GWB5
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

765912:THIMO RS13505
gene id: 765912:THIMO_RS13505
uniprot id: L0H1T5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

765912:THIMO RS16740
gene id: 765912:THIMO_RS16740
uniprot id: L0H1R9
names: Similarity
messages: Belongs to the UPF0229 family.

765912:THIMO RS12595
gene id: 765912:THIMO_RS12595
uniprot id: L0H145
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

765912:THIMO RS05685
gene id: 765912:THIMO_RS05685
uniprot id: U3GLE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

765912:THIMO RS10490
gene id: 765912:THIMO_RS10490
uniprot id: L0GYA5
names: Similarity
messages: Belongs to the P(II) protein family.

765912:THIMO RS16830
gene id: 765912:THIMO_RS16830
uniprot id: L0H3N0
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS00025
gene id: 765912:THIMO_RS00025
uniprot id: L0GQ47
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

765912:THIMO RS16375
gene id: 765912:THIMO_RS16375
uniprot id: L0H240
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

765912:THIMO RS07250
gene id: 765912:THIMO_RS07250
uniprot id: L0GY43
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

765912:THIMO RS11215
gene id: 765912:THIMO_RS11215
uniprot id: L0GYQ4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

765912:THIMO RS10380
gene id: 765912:THIMO_RS10380
uniprot id: L0H014
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS09600
gene id: 765912:THIMO_RS09600
uniprot id: L0GY66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

765912:THIMO RS07775
gene id: 765912:THIMO_RS07775
uniprot id: L0GWQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

765912:THIMO RS16865
gene id: 765912:THIMO_RS16865
uniprot id: L0H2D3
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

765912:THIMO RS13305
gene id: 765912:THIMO_RS13305
uniprot id: L0H0C7
names: Similarity
messages: Belongs to the peptidase M20A family. ArgE subfamily.

765912:THIMO RS10485
gene id: 765912:THIMO_RS10485
uniprot id: L0GZY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamD family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

765912:THIMO RS04900
gene id: 765912:THIMO_RS04900
uniprot id: L0GVH8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HesB/IscA family.
messages: Binds 1 iron-sulfur cluster per subunit.
messages: Homodimer.
messages: Required for insertion of 4Fe-4S clusters for at least IspG.

765912:THIMO RS17860
gene id: 765912:THIMO_RS17860
uniprot id: L0H069
names: Function
names: Similarity
messages: Belongs to the GSP E family.
messages: Part of the Type IV secretion system.

765912:THIMO RS13190
gene id: 765912:THIMO_RS13190
uniprot id: L0H0A6
names: Subcellular Location Annotation
messages: Cytoplasm

765912:THIMO RS13610
gene id: 765912:THIMO_RS13610
uniprot id: L0H1P5
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

765912:THIMO RS09745
gene id: 765912:THIMO_RS09745
uniprot id: L0GVJ9
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
messages: Belongs to the Nth/MutY family.

765912:THIMO RS16265
gene id: 765912:THIMO_RS16265
uniprot id: L0H1J1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

765912:THIMO RS10430
gene id: 765912:THIMO_RS10430
uniprot id: L0H020
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

765912:THIMO RS17125
gene id: 765912:THIMO_RS17125
uniprot id: L0GZS5
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

765912:THIMO RS02770
gene id: 765912:THIMO_RS02770
uniprot id: L0GRN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

765912:THIMO RS04980
gene id: 765912:THIMO_RS04980
uniprot id: L0GSV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.

765912:THIMO RS14730
gene id: 765912:THIMO_RS14730
uniprot id: L0H2A5
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS02735
gene id: 765912:THIMO_RS02735
uniprot id: L0GUD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TolB family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: Periplasm
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

765912:THIMO RS09250
gene id: 765912:THIMO_RS09250
uniprot id: L0GZG1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

765912:THIMO RS06450
gene id: 765912:THIMO_RS06450
uniprot id: L0GVX8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

765912:THIMO RS12685
gene id: 765912:THIMO_RS12685
uniprot id: L0GX78
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS14090
gene id: 765912:THIMO_RS14090
uniprot id: L0H241
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS13620
gene id: 765912:THIMO_RS13620
uniprot id: L0H0I1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

765912:THIMO RS06870
gene id: 765912:THIMO_RS06870
uniprot id: L0GY41
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

765912:THIMO RS11370
gene id: 765912:THIMO_RS11370
uniprot id: L0H0K1
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

765912:THIMO RS05925
gene id: 765912:THIMO_RS05925
uniprot id: L0GW33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Cell inner membrane
messages: Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA.
messages: Membrane

765912:THIMO RS01355
gene id: 765912:THIMO_RS01355
uniprot id: U3GLE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

765912:THIMO RS16005
gene id: 765912:THIMO_RS16005
uniprot id: L0GZ60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homodimer.

765912:THIMO RS15445
gene id: 765912:THIMO_RS15445
uniprot id: L0H2P2
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the NapC/NirT/NrfH family.
messages: Binds 4 heme groups per subunit.

765912:THIMO RS06205
gene id: 765912:THIMO_RS06205
uniprot id: L0GTL3
names: Similarity
messages: Belongs to the threonine synthase family.

765912:THIMO RS14380
gene id: 765912:THIMO_RS14380
uniprot id: L0GY71
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP.
messages: Homodimer. Protochlorophyllide reductase is composed of three subunits; BchL, BchN and BchB.

765912:THIMO RS03680
gene id: 765912:THIMO_RS03680
uniprot id: L0GW53
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the RuBisCO small chain family.
messages: Heterohexadecamer of 8 large and 8 small subunits.
messages: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site. Although the small subunit is not catalytic it is essential for maximal activity.
messages: The basic functional RuBisCO is composed of a large chain homodimer in a 'head-to-tail' conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric 'cap' on each end of the 'barrel'.

765912:THIMO RS16640
gene id: 765912:THIMO_RS16640
uniprot id: L0H1Q2
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

765912:THIMO RS14830
gene id: 765912:THIMO_RS14830
uniprot id: L0H2C7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

765912:THIMO RS09320
gene id: 765912:THIMO_RS09320
uniprot id: L0GVD0
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

765912:THIMO RS05375
gene id: 765912:THIMO_RS05375
uniprot id: L0GT33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase U32 family. UbiV subfamily.
messages: Forms an heterodimer with UbiU.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiU, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway.

765912:THIMO RS16845
gene id: 765912:THIMO_RS16845
uniprot id: L0GZM3
names: Similarity
messages: Belongs to the hemerythrin family.

765912:THIMO RS13145
gene id: 765912:THIMO_RS13145
uniprot id: L0H098
names: Function
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate.
messages: Homotetramer.

765912:THIMO RS01350
gene id: 765912:THIMO_RS01350
uniprot id: U3GK54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

765912:THIMO RS10915
gene id: 765912:THIMO_RS10915
uniprot id: L0H080
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Homodimer.

765912:THIMO RS13270
gene id: 765912:THIMO_RS13270
uniprot id: L0H1Q1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

765912:THIMO RS08765
gene id: 765912:THIMO_RS08765
uniprot id: L0GX94
names: Similarity
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

765912:THIMO RS04455
gene id: 765912:THIMO_RS04455
uniprot id: L0GWM0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

765912:THIMO RS13650
gene id: 765912:THIMO_RS13650
uniprot id: L0GXU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

765912:THIMO RS11920
gene id: 765912:THIMO_RS11920
uniprot id: L0H0Q6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

765912:THIMO RS02370
gene id: 765912:THIMO_RS02370
uniprot id: L0GU64
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

765912:THIMO RS13095
gene id: 765912:THIMO_RS13095
uniprot id: L0H066
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

765912:THIMO RS02200
gene id: 765912:THIMO_RS02200
uniprot id: L0GRD9
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD.
messages: The heme is bound between the two transmembrane subunits.

765912:THIMO RS11110
gene id: 765912:THIMO_RS11110
uniprot id: L0GYN6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

765912:THIMO RS13220
gene id: 765912:THIMO_RS13220
uniprot id: L0H1P3
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS08560
gene id: 765912:THIMO_RS08560
uniprot id: L0GUZ2
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS09965
gene id: 765912:THIMO_RS09965
uniprot id: L0GZT4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS16420
gene id: 765912:THIMO_RS16420
uniprot id: L0H1L4
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

765912:THIMO RS03530
gene id: 765912:THIMO_RS03530
uniprot id: L0GW28
names: Similarity
messages: Belongs to the UPF0047 family.

765912:THIMO RS08845
gene id: 765912:THIMO_RS08845
uniprot id: L0GXR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

765912:THIMO RS05600
gene id: 765912:THIMO_RS05600
uniprot id: L0GVI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

765912:THIMO RS09490
gene id: 765912:THIMO_RS09490
uniprot id: L0GY47
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

765912:THIMO RS06210
gene id: 765912:THIMO_RS06210
uniprot id: L0GXR9
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.

765912:THIMO RS03485
gene id: 765912:THIMO_RS03485
uniprot id: L0GUB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamA family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

765912:THIMO RS09085
gene id: 765912:THIMO_RS09085
uniprot id: L0GZ58
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS08865
gene id: 765912:THIMO_RS08865
uniprot id: L0GXB1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

765912:THIMO RS10125
gene id: 765912:THIMO_RS10125
uniprot id: L0GY21
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS08860
gene id: 765912:THIMO_RS08860
uniprot id: L0GZ11
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

765912:THIMO RS02790
gene id: 765912:THIMO_RS02790
uniprot id: L0GTW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

765912:THIMO RS01110
gene id: 765912:THIMO_RS01110
uniprot id: L0GQT6
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS06500
gene id: 765912:THIMO_RS06500
uniprot id: L0GVY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

765912:THIMO RS06350
gene id: 765912:THIMO_RS06350
uniprot id: L0GVW3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).

765912:THIMO RS03205
gene id: 765912:THIMO_RS03205
uniprot id: L0GW41
names: Similarity
messages: Belongs to the PhoH family.

765912:THIMO RS15875
gene id: 765912:THIMO_RS15875
uniprot id: L0H1D2
names: Similarity
messages: Belongs to the asparagine synthetase family.

765912:THIMO RS13575
gene id: 765912:THIMO_RS13575
uniprot id: L0GXS5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

765912:THIMO RS13630
gene id: 765912:THIMO_RS13630
uniprot id: L0H1V6
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Methylated by PrmB.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

765912:THIMO RS05430
gene id: 765912:THIMO_RS05430
uniprot id: L0GXA6
names: Cofactor
names: Similarity
messages: Belongs to the RimK family.
messages: Binds 2 magnesium or manganese ions per subunit.

765912:THIMO RS09150
gene id: 765912:THIMO_RS09150
uniprot id: L0GZE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Cell inner membrane
messages: Homoheptamer.
messages: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.

765912:THIMO RS11590
gene id: 765912:THIMO_RS11590
uniprot id: L0H0P9
names: Similarity
messages: Belongs to the SufE family.
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

765912:THIMO RS07145
gene id: 765912:THIMO_RS07145
uniprot id: L0GY23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

765912:THIMO RS06000
gene id: 765912:THIMO_RS06000
uniprot id: L0GW48
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

765912:THIMO RS04215
gene id: 765912:THIMO_RS04215
uniprot id: L0GWN9
names: Similarity
messages: Belongs to the UPF0047 family.

765912:THIMO RS07130
gene id: 765912:THIMO_RS07130
uniprot id: L0GWS2
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

765912:THIMO RS07115
gene id: 765912:THIMO_RS07115
uniprot id: L0GY88
names: Similarity
messages: Belongs to the V-ATPase D subunit family.

765912:THIMO RS06495
gene id: 765912:THIMO_RS06495
uniprot id: L0GXP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

765912:THIMO RS10510
gene id: 765912:THIMO_RS10510
uniprot id: L0GZY8
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. ArgA subfamily.
messages: Cytoplasm
messages: In bacteria which possess the bifunctional enzyme ornithine acetyltransferase/N-acetylglutamate synthase (ArgJ), ArgA fulfills an anaplerotic role.

765912:THIMO RS10625
gene id: 765912:THIMO_RS10625
uniprot id: L0H023
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

765912:THIMO RS05575
gene id: 765912:THIMO_RS05575
uniprot id: L0GVH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

765912:THIMO RS11175
gene id: 765912:THIMO_RS11175
uniprot id: L0GWF0
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

765912:THIMO RS05650
gene id: 765912:THIMO_RS05650
uniprot id: L0GVJ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
messages: Cell membrane

765912:THIMO RS06035
gene id: 765912:THIMO_RS06035
uniprot id: L0GXG2
names: Similarity
messages: Belongs to the transglycosylase Slt family.

765912:THIMO RS07985
gene id: 765912:THIMO_RS07985
uniprot id: L0GX95
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

765912:THIMO RS17070
gene id: 765912:THIMO_RS17070
uniprot id: L0H2H2
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS06750
gene id: 765912:THIMO_RS06750
uniprot id: L0GXU5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein bS18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS15775
gene id: 765912:THIMO_RS15775
uniprot id: L0H328
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

765912:THIMO RS12480
gene id: 765912:THIMO_RS12480
uniprot id: L0GX38
names: PTM
messages: Binds 1 heme group per subunit.

765912:THIMO RS05140
gene id: 765912:THIMO_RS05140
uniprot id: L0GX52
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

765912:THIMO RS14995
gene id: 765912:THIMO_RS14995
uniprot id: L0H0U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0073 (Hly-III) family.
messages: Membrane

765912:THIMO RS02380
gene id: 765912:THIMO_RS02380
uniprot id: L0GVN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptF/LptG family.
messages: Cell inner membrane
messages: Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).
messages: Membrane
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

765912:THIMO RS11225
gene id: 765912:THIMO_RS11225
uniprot id: L0GWG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

765912:THIMO RS13600
gene id: 765912:THIMO_RS13600
uniprot id: L0GXT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

765912:THIMO RS10235
gene id: 765912:THIMO_RS10235
uniprot id: L0GVU0
names: Similarity
messages: Belongs to the peptidase C40 family.

765912:THIMO RS08825
gene id: 765912:THIMO_RS08825
uniprot id: L0GV38
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

765912:THIMO RS05725
gene id: 765912:THIMO_RS05725
uniprot id: L0GVK9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

765912:THIMO RS00295
gene id: 765912:THIMO_RS00295
uniprot id: L0GSH3
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS05010
gene id: 765912:THIMO_RS05010
uniprot id: L0GX25
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the malate synthase family. GlcB subfamily.
messages: Cytoplasm
messages: Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

765912:THIMO RS08595
gene id: 765912:THIMO_RS08595
uniprot id: L0GYW5
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

765912:THIMO RS12925
gene id: 765912:THIMO_RS12925
uniprot id: L0H1F6
names: Similarity
messages: Belongs to the hemerythrin family.

765912:THIMO RS12420
gene id: 765912:THIMO_RS12420
uniprot id: L0GZD4
names: Similarity
messages: Belongs to the transposase 11 family.

765912:THIMO RS00915
gene id: 765912:THIMO_RS00915
uniprot id: L0GTC8
names: Similarity
messages: Belongs to the GARS family.

765912:THIMO RS10955
gene id: 765912:THIMO_RS10955
uniprot id: L0GWA6
names: Subcellular Location Annotation
messages: Cytoplasm

765912:THIMO RS05450
gene id: 765912:THIMO_RS05450
uniprot id: L0GT43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

765912:THIMO RS10925
gene id: 765912:THIMO_RS10925
uniprot id: L0GYX2
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

765912:THIMO RS07920
gene id: 765912:THIMO_RS07920
uniprot id: L0GWT7
names: Similarity
messages: Belongs to the HSP15 family.

765912:THIMO RS17340
gene id: 765912:THIMO_RS17340
uniprot id: L0H244
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

765912:THIMO RS07750
gene id: 765912:THIMO_RS07750
uniprot id: L0GWP8
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

765912:THIMO RS05850
gene id: 765912:THIMO_RS05850
uniprot id: L0GW21
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS05710
gene id: 765912:THIMO_RS05710
uniprot id: L0GTC1
names: Similarity
messages: Belongs to the peptidase M24B family.

765912:THIMO RS17035
gene id: 765912:THIMO_RS17035
uniprot id: L0H3J6
names: Similarity
messages: Belongs to the asparagine synthetase family.

765912:THIMO RS00955
gene id: 765912:THIMO_RS00955
uniprot id: L0GUN0
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS03210
gene id: 765912:THIMO_RS03210
uniprot id: L0GVX7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

765912:THIMO RS12130
gene id: 765912:THIMO_RS12130
uniprot id: L0GWW8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

765912:THIMO RS02080
gene id: 765912:THIMO_RS02080
uniprot id: L0GVH1
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

765912:THIMO RS17285
gene id: 765912:THIMO_RS17285
uniprot id: L0H3P3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

765912:THIMO RS15625
gene id: 765912:THIMO_RS15625
uniprot id: L0H183
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

765912:THIMO RS06580
gene id: 765912:THIMO_RS06580
uniprot id: L0GTT6
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

765912:THIMO RS15905
gene id: 765912:THIMO_RS15905
uniprot id: L0H1V4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
messages: Cell membrane
messages: Heterodimer of a large and a small subunit.

765912:THIMO RS10190
gene id: 765912:THIMO_RS10190
uniprot id: L0GZX6
names: Cofactor
messages: Binds 2 Mg(2+) ions per monomer.

765912:THIMO RS05040
gene id: 765912:THIMO_RS05040
uniprot id: L0GX30
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

765912:THIMO RS15350
gene id: 765912:THIMO_RS15350
uniprot id: L0H1H7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

765912:THIMO RS11685
gene id: 765912:THIMO_RS11685
uniprot id: L0GZB5
names: Function
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
messages: DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.

765912:THIMO RS01810
gene id: 765912:THIMO_RS01810
uniprot id: L0GTV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

765912:THIMO RS16285
gene id: 765912:THIMO_RS16285
uniprot id: L0H354
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS04450
gene id: 765912:THIMO_RS04450
uniprot id: L0GWT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

765912:THIMO RS13335
gene id: 765912:THIMO_RS13335
uniprot id: L0H0D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

765912:THIMO RS08525
gene id: 765912:THIMO_RS08525
uniprot id: L0GX61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family. ParE type 1 subfamily.
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

765912:THIMO RS05955
gene id: 765912:THIMO_RS05955
uniprot id: L0GTG8
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

765912:THIMO RS09505
gene id: 765912:THIMO_RS09505
uniprot id: L0GZE8
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

765912:THIMO RS07395
gene id: 765912:THIMO_RS07395
uniprot id: L0GWG9
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS01980
gene id: 765912:THIMO_RS01980
uniprot id: L0GV86
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Monomer.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

765912:THIMO RS12145
gene id: 765912:THIMO_RS12145
uniprot id: L0GZ68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

765912:THIMO RS01570
gene id: 765912:THIMO_RS01570
uniprot id: L0GV00
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

765912:THIMO RS00270
gene id: 765912:THIMO_RS00270
uniprot id: L0GSG8
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

765912:THIMO RS09995
gene id: 765912:THIMO_RS09995
uniprot id: L0GZN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

765912:THIMO RS14105
gene id: 765912:THIMO_RS14105
uniprot id: L0H0S2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

765912:THIMO RS08840
gene id: 765912:THIMO_RS08840
uniprot id: L0GXA7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

765912:THIMO RS06405
gene id: 765912:THIMO_RS06405
uniprot id: L0GWC8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 1 copper ion per subunit, denoted as copper B.
messages: Binds 2 heme groups per subunit, denoted as high- and low-spin.
messages: Membrane

765912:THIMO RS08585
gene id: 765912:THIMO_RS08585
uniprot id: L0GUZ7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.

765912:THIMO RS05605
gene id: 765912:THIMO_RS05605
uniprot id: L0GVY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

765912:THIMO RS07590
gene id: 765912:THIMO_RS07590
uniprot id: L0GYB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0114 family.
messages: Cell membrane
messages: Membrane

765912:THIMO RS09390
gene id: 765912:THIMO_RS09390
uniprot id: L0GY28
names: Similarity
messages: Belongs to the Skp family.

765912:THIMO RS04665
gene id: 765912:THIMO_RS04665
uniprot id: L0GSQ8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

765912:THIMO RS05550
gene id: 765912:THIMO_RS05550
uniprot id: L0GVG9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.

765912:THIMO RS05765
gene id: 765912:THIMO_RS05765
uniprot id: L0GXJ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: Homotrimer.

765912:THIMO RS10690
gene id: 765912:THIMO_RS10690
uniprot id: L0GW55
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

765912:THIMO RS12280
gene id: 765912:THIMO_RS12280
uniprot id: L0GWZ4
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

765912:THIMO RS16060
gene id: 765912:THIMO_RS16060
uniprot id: L0H385
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

765912:THIMO RS12640
gene id: 765912:THIMO_RS12640
uniprot id: L0H197
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS07460
gene id: 765912:THIMO_RS07460
uniprot id: L0GY90
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS05025
gene id: 765912:THIMO_RS05025
uniprot id: L0GV44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

765912:THIMO RS03025
gene id: 765912:THIMO_RS03025
uniprot id: L0GUJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

765912:THIMO RS06285
gene id: 765912:THIMO_RS06285
uniprot id: L0GTM8
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

765912:THIMO RS00425
gene id: 765912:THIMO_RS00425
uniprot id: L0GUD5
names: Similarity
messages: Belongs to the glutamate synthase family.

765912:THIMO RS15230
gene id: 765912:THIMO_RS15230
uniprot id: L0H2K6
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS10195
gene id: 765912:THIMO_RS10195
uniprot id: L0GZS6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

765912:THIMO RS04640
gene id: 765912:THIMO_RS04640
uniprot id: L0GSQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

765912:THIMO RS07245
gene id: 765912:THIMO_RS07245
uniprot id: L0GYB2
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

765912:THIMO RS12120
gene id: 765912:THIMO_RS12120
uniprot id: L0GZ61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

765912:THIMO RS11120
gene id: 765912:THIMO_RS11120
uniprot id: L0GWE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

765912:THIMO RS11320
gene id: 765912:THIMO_RS11320
uniprot id: L0H0J0
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

765912:THIMO RS14260
gene id: 765912:THIMO_RS14260
uniprot id: U3GM69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reaction center PufL/M/PsbA/D family.
messages: Membrane
messages: The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis.

765912:THIMO RS12015
gene id: 765912:THIMO_RS12015
uniprot id: L0GZ40
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

765912:THIMO RS09480
gene id: 765912:THIMO_RS09480
uniprot id: L0GZE5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

765912:THIMO RS17185
gene id: 765912:THIMO_RS17185
uniprot id: L0H3M3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoH subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.

765912:THIMO RS06490
gene id: 765912:THIMO_RS06490
uniprot id: L0GXX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmD/CycX/HelD family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

765912:THIMO RS13380
gene id: 765912:THIMO_RS13380
uniprot id: L0GZY7
names: PTM
messages: Binds 2 heme c groups covalently per subunit.

765912:THIMO RS00190
gene id: 765912:THIMO_RS00190
uniprot id: L0GU71
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

765912:THIMO RS01590
gene id: 765912:THIMO_RS01590
uniprot id: L0GV72
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

765912:THIMO RS12635
gene id: 765912:THIMO_RS12635
uniprot id: L0GX70
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS06445
gene id: 765912:THIMO_RS06445
uniprot id: L0GXN5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

765912:THIMO RS08085
gene id: 765912:THIMO_RS08085
uniprot id: L0GXD3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

765912:THIMO RS06545
gene id: 765912:THIMO_RS06545
uniprot id: L0GXQ6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

765912:THIMO RS18400
gene id: 765912:THIMO_RS18400
uniprot id: L0H1Q4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

765912:THIMO RS02775
gene id: 765912:THIMO_RS02775
uniprot id: L0GVU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

765912:THIMO RS06510
gene id: 765912:THIMO_RS06510
uniprot id: L0GTS0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

765912:THIMO RS03620
gene id: 765912:THIMO_RS03620
uniprot id: L0GS70
names: Similarity
messages: Belongs to the YicC/YloC family.

765912:THIMO RS05615
gene id: 765912:THIMO_RS05615
uniprot id: L0GXG4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

765912:THIMO RS11090
gene id: 765912:THIMO_RS11090
uniprot id: L0GZ01
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS12185
gene id: 765912:THIMO_RS12185
uniprot id: L0H111
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

765912:THIMO RS01000
gene id: 765912:THIMO_RS01000
uniprot id: L0GUN8
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).

765912:THIMO RS18040
gene id: 765912:THIMO_RS18040
uniprot id: L0GT18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell inner membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

765912:THIMO RS13035
gene id: 765912:THIMO_RS13035
uniprot id: L0H1I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

765912:THIMO RS03585
gene id: 765912:THIMO_RS03585
uniprot id: L0GUC6
names: Similarity
messages: Belongs to the UPF0235 family.

765912:THIMO RS08570
gene id: 765912:THIMO_RS08570
uniprot id: L0GYW2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

765912:THIMO RS11695
gene id: 765912:THIMO_RS11695
uniprot id: L0H0R7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif.
messages: Homohexamer. Forms a ring that surrounds DNA.
messages: Membrane

765912:THIMO RS05570
gene id: 765912:THIMO_RS05570
uniprot id: L0GX84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

765912:THIMO RS09040
gene id: 765912:THIMO_RS09040
uniprot id: L0GXE2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

765912:THIMO RS13475
gene id: 765912:THIMO_RS13475
uniprot id: L0H1T2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

765912:THIMO RS03715
gene id: 765912:THIMO_RS03715
uniprot id: L0GS86
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

765912:THIMO RS14125
gene id: 765912:THIMO_RS14125
uniprot id: L0H0A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: Periplasm

765912:THIMO RS10940
gene id: 765912:THIMO_RS10940
uniprot id: L0H084
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

765912:THIMO RS11190
gene id: 765912:THIMO_RS11190
uniprot id: L0GYQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

765912:THIMO RS01845
gene id: 765912:THIMO_RS01845
uniprot id: L0GVC0
names: Similarity
messages: Belongs to the YkuD family.

765912:THIMO RS04660
gene id: 765912:THIMO_RS04660
uniprot id: L0GVE4
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

765912:THIMO RS00615
gene id: 765912:THIMO_RS00615
uniprot id: L0GQJ4
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

765912:THIMO RS05350
gene id: 765912:THIMO_RS05350
uniprot id: L0GVQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

765912:THIMO RS11565
gene id: 765912:THIMO_RS11565
uniprot id: L0H0P5
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS09775
gene id: 765912:THIMO_RS09775
uniprot id: L0GVK4
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS06050
gene id: 765912:THIMO_RS06050
uniprot id: L0GTI6
names: Similarity
messages: Belongs to the UPF0125 (RnfH) family.

765912:THIMO RS10360
gene id: 765912:THIMO_RS10360
uniprot id: L0GY77
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

765912:THIMO RS11610
gene id: 765912:THIMO_RS11610
uniprot id: L0GZ99
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

765912:THIMO RS15075
gene id: 765912:THIMO_RS15075
uniprot id: L0H1B6
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.

765912:THIMO RS03400
gene id: 765912:THIMO_RS03400
uniprot id: L0GW76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Cytoplasm
messages: Homodimer.

765912:THIMO RS05050
gene id: 765912:THIMO_RS05050
uniprot id: L0GV49
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

765912:THIMO RS09530
gene id: 765912:THIMO_RS09530
uniprot id: L0GZF3
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

765912:THIMO RS07905
gene id: 765912:THIMO_RS07905
uniprot id: L0GUH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CysZ family.
messages: Cell inner membrane
messages: High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway.

765912:THIMO RS17505
gene id: 765912:THIMO_RS17505
uniprot id: L0H3T8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

765912:THIMO RS12930
gene id: 765912:THIMO_RS12930
uniprot id: L0H1A8
names: Similarity
messages: Belongs to the class-A beta-lactamase family.

765912:THIMO RS09880
gene id: 765912:THIMO_RS09880
uniprot id: L0GXW3
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS12095
gene id: 765912:THIMO_RS12095
uniprot id: L0GZK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

765912:THIMO RS07030
gene id: 765912:THIMO_RS07030
uniprot id: L0GY74
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

765912:THIMO RS15865
gene id: 765912:THIMO_RS15865
uniprot id: L0H350
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase T family.
messages: Binds two Mg(2+) per subunit. The active form of the enzyme binds two Mg(2+) ions in its active site. The first Mg(2+) forms only one salt bridge with the protein.
messages: Homodimer.
messages: Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis.

765912:THIMO RS05735
gene id: 765912:THIMO_RS05735
uniprot id: L0GTC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

765912:THIMO RS11605
gene id: 765912:THIMO_RS11605
uniprot id: L0GYW6
names: Similarity
messages: Belongs to the aspartokinase family.

765912:THIMO RS02310
gene id: 765912:THIMO_RS02310
uniprot id: L0GVF2
names: Cofactor
messages: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.

765912:THIMO RS13045
gene id: 765912:THIMO_RS13045
uniprot id: L0GZQ2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

765912:THIMO RS16075
gene id: 765912:THIMO_RS16075
uniprot id: L0H1Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

765912:THIMO RS00905
gene id: 765912:THIMO_RS00905
uniprot id: L0GUM3
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

765912:THIMO RS05660
gene id: 765912:THIMO_RS05660
uniprot id: L0GTB2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

765912:THIMO RS08615
gene id: 765912:THIMO_RS08615
uniprot id: L0GZ39
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

765912:THIMO RS05595
gene id: 765912:THIMO_RS05595
uniprot id: L0GX93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

765912:THIMO RS08830
gene id: 765912:THIMO_RS08830
uniprot id: L0GZ77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

765912:THIMO RS10830
gene id: 765912:THIMO_RS10830
uniprot id: L0H0A5
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.

765912:THIMO RS06180
gene id: 765912:THIMO_RS06180
uniprot id: L0GTL0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS05780
gene id: 765912:THIMO_RS05780
uniprot id: L0GW11
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.

765912:THIMO RS15145
gene id: 765912:THIMO_RS15145
uniprot id: L0H1D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

765912:THIMO RS02150
gene id: 765912:THIMO_RS02150
uniprot id: L0GU18
names: Similarity
messages: Belongs to the UPF0047 family.

765912:THIMO RS14630
gene id: 765912:THIMO_RS14630
uniprot id: L0H0L5
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS08650
gene id: 765912:THIMO_RS08650
uniprot id: L0GX79
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

765912:THIMO RS00205
gene id: 765912:THIMO_RS00205
uniprot id: L0GQ85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP G family.
messages: Cell inner membrane
messages: Membrane

765912:THIMO RS13550
gene id: 765912:THIMO_RS13550
uniprot id: L0GXS0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

765912:THIMO RS08305
gene id: 765912:THIMO_RS08305
uniprot id: L0GYY7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

765912:THIMO RS08600
gene id: 765912:THIMO_RS08600
uniprot id: L0GX73
names: Similarity
messages: Belongs to the asparagine synthetase family.

765912:THIMO RS13105
gene id: 765912:THIMO_RS13105
uniprot id: L0H1J7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

765912:THIMO RS03110
gene id: 765912:THIMO_RS03110
uniprot id: L0GRX1
names: Similarity
messages: Belongs to the GSP E family.

765912:THIMO RS14405
gene id: 765912:THIMO_RS14405
uniprot id: L0GY75
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS15005
gene id: 765912:THIMO_RS15005
uniprot id: L0GYI6
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS12055
gene id: 765912:THIMO_RS12055
uniprot id: L0H0Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

765912:THIMO RS05645
gene id: 765912:THIMO_RS05645
uniprot id: L0GXA2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

765912:THIMO RS04420
gene id: 765912:THIMO_RS04420
uniprot id: L0GSL6
names: Subcellular Location Annotation
messages: Cell inner membrane

765912:THIMO RS05080
gene id: 765912:THIMO_RS05080
uniprot id: L0GVK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

765912:THIMO RS12225
gene id: 765912:THIMO_RS12225
uniprot id: L0GZN7
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

765912:THIMO RS08760
gene id: 765912:THIMO_RS08760
uniprot id: L0GYZ1
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

765912:THIMO RS08635
gene id: 765912:THIMO_RS08635
uniprot id: L0GV05
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

765912:THIMO RS12630
gene id: 765912:THIMO_RS12630
uniprot id: L0GZX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family. MetZ subfamily.
messages: Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide.
messages: Homotetramer.

765912:THIMO RS16470
gene id: 765912:THIMO_RS16470
uniprot id: L0H387
names: Similarity
messages: Belongs to the HsdR family.

765912:THIMO RS09785
gene id: 765912:THIMO_RS09785
uniprot id: L0GZJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

765912:THIMO RS14510
gene id: 765912:THIMO_RS14510
uniprot id: L0H2C1
names: Similarity
messages: Belongs to the MEMO1 family.

765912:THIMO RS07650
gene id: 765912:THIMO_RS07650
uniprot id: L0GX26
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

765912:THIMO RS09835
gene id: 765912:THIMO_RS09835
uniprot id: L0GZK0
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

765912:THIMO RS13400
gene id: 765912:THIMO_RS13400
uniprot id: L0H1L8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

765912:THIMO RS11520
gene id: 765912:THIMO_RS11520
uniprot id: L0H0I3
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS07930
gene id: 765912:THIMO_RS07930
uniprot id: L0GUI1
names: Similarity
messages: Belongs to the peptidase M1 family.

765912:THIMO RS11235
gene id: 765912:THIMO_RS11235
uniprot id: L0H0D3
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

765912:THIMO RS01730
gene id: 765912:THIMO_RS01730
uniprot id: L0GTT8
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS13525
gene id: 765912:THIMO_RS13525
uniprot id: L0GXR7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

765912:THIMO RS16345
gene id: 765912:THIMO_RS16345
uniprot id: L0H1K4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

765912:THIMO RS06745
gene id: 765912:THIMO_RS06745
uniprot id: L0GY17
names: Similarity
messages: Belongs to the group II decarboxylase family.

765912:THIMO RS06485
gene id: 765912:THIMO_RS06485
uniprot id: L0GTR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmE/CycJ family.
messages: Cell membrane
messages: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.

765912:THIMO RS02835
gene id: 765912:THIMO_RS02835
uniprot id: L0GVP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: Composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

765912:THIMO RS03610
gene id: 765912:THIMO_RS03610
uniprot id: L0GUD0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

765912:THIMO RS14020
gene id: 765912:THIMO_RS14020
uniprot id: L0H1W2
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the RuBisCO small chain family.
messages: Heterohexadecamer of 8 large and 8 small subunits.
messages: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site. Although the small subunit is not catalytic it is essential for maximal activity.
messages: The basic functional RuBisCO is composed of a large chain homodimer in a 'head-to-tail' conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric 'cap' on each end of the 'barrel'.

765912:THIMO RS16600
gene id: 765912:THIMO_RS16600
uniprot id: L0GZH1
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS05960
gene id: 765912:THIMO_RS05960
uniprot id: L0GXM2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

765912:THIMO RS02070
gene id: 765912:THIMO_RS02070
uniprot id: L0GU05
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

765912:THIMO RS17590
gene id: 765912:THIMO_RS17590
uniprot id: L0H2R5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS01300
gene id: 765912:THIMO_RS01300
uniprot id: L0GT13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Cell inner membrane
messages: FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

765912:THIMO RS02065
gene id: 765912:THIMO_RS02065
uniprot id: L0GTG4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

765912:THIMO RS14395
gene id: 765912:THIMO_RS14395
uniprot id: L0H0G4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BchN/ChlN family.
messages: Binds 1 [4Fe-4S] cluster per heterodimer. The cluster is bound at the heterodimer interface by residues from both subunits.
messages: Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (BchN-BchB) is the catalytic component of the complex.
messages: Protochlorophyllide reductase is composed of three subunits; BchL, BchN and BchB. Forms a heterotetramer of two BchB and two BchN subunits.

765912:THIMO RS18610
gene id: 765912:THIMO_RS18610
uniprot id: L0H2W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrbI/VirB10 family.
messages: Membrane

765912:THIMO RS08015
gene id: 765912:THIMO_RS08015
uniprot id: L0GUK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

765912:THIMO RS00715
gene id: 765912:THIMO_RS00715
uniprot id: L0GQL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dsrC/tusE family.
messages: Cytoplasm
messages: Part of a sulfur-relay system.

765912:THIMO RS06310
gene id: 765912:THIMO_RS06310
uniprot id: L0GTN2
names: Function
names: Subunit
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.

765912:THIMO RS13155
gene id: 765912:THIMO_RS13155
uniprot id: L0H1M7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptA family.
messages: Component of the lipopolysaccharide transport and assembly complex.
messages: Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.
messages: Periplasm

765912:THIMO RS00015
gene id: 765912:THIMO_RS00015
uniprot id: L0GSA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

765912:THIMO RS05975
gene id: 765912:THIMO_RS05975
uniprot id: L0GW42
names: Similarity
messages: Belongs to the Smg family.

765912:THIMO RS15840
gene id: 765912:THIMO_RS15840
uniprot id: L0GZ28
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

765912:THIMO RS04505
gene id: 765912:THIMO_RS04505
uniprot id: L0GWU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

765912:THIMO RS12305
gene id: 765912:THIMO_RS12305
uniprot id: L0GWZ8
names: Similarity
messages: Belongs to the BolA/IbaG family.

765912:THIMO RS12175
gene id: 765912:THIMO_RS12175
uniprot id: L0GZM4
names: Similarity
messages: Belongs to the UPF0125 (RnfH) family.

765912:THIMO RS17205
gene id: 765912:THIMO_RS17205
uniprot id: L0H3V9
names: Similarity
messages: Belongs to the peptidase M16 family.

765912:THIMO RS04365
gene id: 765912:THIMO_RS04365
uniprot id: L0GV91
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS15810
gene id: 765912:THIMO_RS15810
uniprot id: L0H1B9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

765912:THIMO RS12115
gene id: 765912:THIMO_RS12115
uniprot id: L0H0U0
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.

765912:THIMO RS08215
gene id: 765912:THIMO_RS08215
uniprot id: L0GXF5
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

765912:THIMO RS02425
gene id: 765912:THIMO_RS02425
uniprot id: L0GU75
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

765912:THIMO RS01705
gene id: 765912:THIMO_RS01705
uniprot id: L0GT82
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer and homodimer.

765912:THIMO RS00660
gene id: 765912:THIMO_RS00660
uniprot id: L0GT81
names: Similarity
messages: Belongs to the peptidase U62 family.

765912:THIMO RS06065
gene id: 765912:THIMO_RS06065
uniprot id: L0GVS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

765912:THIMO RS04990
gene id: 765912:THIMO_RS04990
uniprot id: L0GWW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP E family.
messages: Cytoplasm

765912:THIMO RS10225
gene id: 765912:THIMO_RS10225
uniprot id: L0GY46
names: Similarity
messages: Belongs to the UPF0178 family.

765912:THIMO RS16585
gene id: 765912:THIMO_RS16585
uniprot id: L0H3B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

765912:THIMO RS17865
gene id: 765912:THIMO_RS17865
uniprot id: L0H489
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VirD4/TraG family.
messages: Membrane

765912:THIMO RS17390
gene id: 765912:THIMO_RS17390
uniprot id: L0H2M9
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS16155
gene id: 765912:THIMO_RS16155
uniprot id: L0H335
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

765912:THIMO RS08325
gene id: 765912:THIMO_RS08325
uniprot id: L0GUU9
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

765912:THIMO RS05695
gene id: 765912:THIMO_RS05695
uniprot id: L0GXA9
names: Function
names: Similarity
names: Subunit
messages: Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.
messages: Belongs to the ZapA family. Type 1 subfamily.
messages: Homodimer. Interacts with FtsZ.

765912:THIMO RS07865
gene id: 765912:THIMO_RS07865
uniprot id: L0GYG5
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

765912:THIMO RS14525
gene id: 765912:THIMO_RS14525
uniprot id: L0H0I9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

765912:THIMO RS08835
gene id: 765912:THIMO_RS08835
uniprot id: L0GZ06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

765912:THIMO RS04225
gene id: 765912:THIMO_RS04225
uniprot id: L0GUN7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IPP isomerase type 1 family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Cytoplasm

765912:THIMO RS13605
gene id: 765912:THIMO_RS13605
uniprot id: L0H1V2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

765912:THIMO RS01410
gene id: 765912:THIMO_RS01410
uniprot id: L0GQZ0
names: Similarity
messages: Belongs to the MotB family.

765912:THIMO RS09605
gene id: 765912:THIMO_RS09605
uniprot id: L0GVH6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

765912:THIMO RS12110
gene id: 765912:THIMO_RS12110
uniprot id: L0H0Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

765912:THIMO RS05225
gene id: 765912:THIMO_RS05225
uniprot id: L0GX01
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

765912:THIMO RS08545
gene id: 765912:THIMO_RS08545
uniprot id: L0GYV8
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS13500
gene id: 765912:THIMO_RS13500
uniprot id: L0GXR2
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

765912:THIMO RS07655
gene id: 765912:THIMO_RS07655
uniprot id: L0GUD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

765912:THIMO RS13495
gene id: 765912:THIMO_RS13495
uniprot id: L0H0F5
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

765912:THIMO RS05295
gene id: 765912:THIMO_RS05295
uniprot id: L0GT17
names: Cofactor
names: Similarity
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.

765912:THIMO RS14210
gene id: 765912:THIMO_RS14210
uniprot id: L0H0D5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers.
messages: Belongs to the antenna complex beta subunit family.
messages: Cell inner membrane
messages: Membrane

765912:THIMO RS06020
gene id: 765912:THIMO_RS06020
uniprot id: L0GW52
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

765912:THIMO RS12140
gene id: 765912:THIMO_RS12140
uniprot id: L0H0U6
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

765912:THIMO RS04355
gene id: 765912:THIMO_RS04355
uniprot id: L0GWJ9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

765912:THIMO RS05990
gene id: 765912:THIMO_RS05990
uniprot id: L0GXF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

765912:THIMO RS14205
gene id: 765912:THIMO_RS14205
uniprot id: L0GY40
names: Function
messages: Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers.

765912:THIMO RS08010
gene id: 765912:THIMO_RS08010
uniprot id: L0GXA1
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

765912:THIMO RS12000
gene id: 765912:THIMO_RS12000
uniprot id: L0GWU6
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

765912:THIMO RS12915
gene id: 765912:THIMO_RS12915
uniprot id: L0H026
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS13810
gene id: 765912:THIMO_RS13810
uniprot id: L0H050
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

765912:THIMO RS03135
gene id: 765912:THIMO_RS03135
uniprot id: L0GW29
names: Similarity
messages: Belongs to the transglycosylase Slt family.

765912:THIMO RS14340
gene id: 765912:THIMO_RS14340
uniprot id: L0H227
names: Function
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.
messages: Involved in bacteriochlorophyll biosynthesis; introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX.

765912:THIMO RS17635
gene id: 765912:THIMO_RS17635
uniprot id: L0H022
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

765912:THIMO RS09200
gene id: 765912:THIMO_RS09200
uniprot id: L0GZF5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

765912:THIMO RS15025
gene id: 765912:THIMO_RS15025
uniprot id: L0H1A5
names: Similarity
messages: Belongs to the YkuD family.

765912:THIMO RS01290
gene id: 765912:THIMO_RS01290
uniprot id: L0GV08
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

765912:THIMO RS14330
gene id: 765912:THIMO_RS14330
uniprot id: L0GY62
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

765912:THIMO RS12250
gene id: 765912:THIMO_RS12250
uniprot id: L0GZP1
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

765912:THIMO RS06290
gene id: 765912:THIMO_RS06290
uniprot id: L0GXT3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

765912:THIMO RS06225
gene id: 765912:THIMO_RS06225
uniprot id: L0GW93
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS10850
gene id: 765912:THIMO_RS10850
uniprot id: L0GW91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

765912:THIMO RS13520
gene id: 765912:THIMO_RS13520
uniprot id: L0H0G0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

765912:THIMO RS15135
gene id: 765912:THIMO_RS15135
uniprot id: L0H2I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

765912:THIMO RS06855
gene id: 765912:THIMO_RS06855
uniprot id: L0GW51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

765912:THIMO RS12705
gene id: 765912:THIMO_RS12705
uniprot id: L0GZY6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

765912:THIMO RS10645
gene id: 765912:THIMO_RS10645
uniprot id: L0H075
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation.
messages: May be beta-lysylated on the epsilon-amino group of Lys-34 by the combined action of EpmA and EpmB, and then hydroxylated on the C5 position of the same residue by EpmC (if this protein is present). Lysylation is critical for the stimulatory effect of EF-P on peptide-bond formation. The lysylation moiety may extend toward the peptidyltransferase center and stabilize the terminal 3-CCA end of the tRNA. Hydroxylation of the C5 position on Lys-34 may allow additional potential stabilizing hydrogen-bond interactions with the P-tRNA.

765912:THIMO RS07505
gene id: 765912:THIMO_RS07505
uniprot id: L0GYG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane

765912:THIMO RS12210
gene id: 765912:THIMO_RS12210
uniprot id: L0H116
names: Similarity
messages: Belongs to the prokaryotic GSH synthase family.

765912:THIMO RS02800
gene id: 765912:THIMO_RS02800
uniprot id: L0GRP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

765912:THIMO RS17135
gene id: 765912:THIMO_RS17135
uniprot id: L0H3L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

765912:THIMO RS02720
gene id: 765912:THIMO_RS02720
uniprot id: L0GVT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbB/TolQ family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

765912:THIMO RS09335
gene id: 765912:THIMO_RS09335
uniprot id: L0GXJ4
names: Similarity
messages: Belongs to the transglycosylase Slt family.

765912:THIMO RS02670
gene id: 765912:THIMO_RS02670
uniprot id: L0GVS9
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

765912:THIMO RS03370
gene id: 765912:THIMO_RS03370
uniprot id: L0GS24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

765912:THIMO RS11545
gene id: 765912:THIMO_RS11545
uniprot id: L0H0I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

765912:THIMO RS11130
gene id: 765912:THIMO_RS11130
uniprot id: L0H0B8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS02530
gene id: 765912:THIMO_RS02530
uniprot id: L0GRJ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YceF subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

765912:THIMO RS16710
gene id: 765912:THIMO_RS16710
uniprot id: L0H3D5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

765912:THIMO RS03675
gene id: 765912:THIMO_RS03675
uniprot id: L0GWD2
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the RuBisCO large chain family. Type I subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterohexadecamer of 8 large chains and 8 small chains.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.
messages: The basic functional RuBisCO is composed of a large chain homodimer in a 'head-to-tail' conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric 'cap' on each end of the 'barrel'.

765912:THIMO RS07085
gene id: 765912:THIMO_RS07085
uniprot id: L0GY14
names: Similarity
messages: Belongs to the UPF0234 family.

765912:THIMO RS16365
gene id: 765912:THIMO_RS16365
uniprot id: L0H369
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

765912:THIMO RS04005
gene id: 765912:THIMO_RS04005
uniprot id: L0GV18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.

765912:THIMO RS12165
gene id: 765912:THIMO_RS12165
uniprot id: L0H0V0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

765912:THIMO RS10205
gene id: 765912:THIMO_RS10205
uniprot id: L0GYI0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

765912:THIMO RS08165
gene id: 765912:THIMO_RS08165
uniprot id: L0GUR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LapB family.
messages: Cell inner membrane
messages: Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.

765912:THIMO RS14000
gene id: 765912:THIMO_RS14000
uniprot id: L0H082
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

765912:THIMO RS08990
gene id: 765912:THIMO_RS08990
uniprot id: L0GZ37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

765912:THIMO RS13645
gene id: 765912:THIMO_RS13645
uniprot id: L0H0I6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

765912:THIMO RS00720
gene id: 765912:THIMO_RS00720
uniprot id: L0GUQ1
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS12425
gene id: 765912:THIMO_RS12425
uniprot id: L0GZT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

765912:THIMO RS05580
gene id: 765912:THIMO_RS05580
uniprot id: L0GVX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

765912:THIMO RS07365
gene id: 765912:THIMO_RS07365
uniprot id: L0GY68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

765912:THIMO RS08855
gene id: 765912:THIMO_RS08855
uniprot id: L0GZ81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

765912:THIMO RS11340
gene id: 765912:THIMO_RS11340
uniprot id: L0GWH8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

765912:THIMO RS16085
gene id: 765912:THIMO_RS16085
uniprot id: L0H390
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

765912:THIMO RS05440
gene id: 765912:THIMO_RS05440
uniprot id: L0GVD3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

765912:THIMO RS09060
gene id: 765912:THIMO_RS09060
uniprot id: L0GZ52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

765912:THIMO RS03115
gene id: 765912:THIMO_RS03115
uniprot id: L0GW26
names: Similarity
messages: Belongs to the GSP E family.

765912:THIMO RS03560
gene id: 765912:THIMO_RS03560
uniprot id: L0GUC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

765912:THIMO RS01020
gene id: 765912:THIMO_RS01020
uniprot id: L0GUV5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

765912:THIMO RS12565
gene id: 765912:THIMO_RS12565
uniprot id: L0H185
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS14345
gene id: 765912:THIMO_RS14345
uniprot id: L0H0F3
names: Function
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.
messages: Involved in bacteriochlorophyll biosynthesis; introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX.

765912:THIMO RS11505
gene id: 765912:THIMO_RS11505
uniprot id: L0GZ82
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS08175
gene id: 765912:THIMO_RS08175
uniprot id: L0GYQ2
names: Similarity
messages: Belongs to the UDPGP type 2 family.

765912:THIMO RS16205
gene id: 765912:THIMO_RS16205
uniprot id: L0H340
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

765912:THIMO RS05690
gene id: 765912:THIMO_RS05690
uniprot id: L0GXH7
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

765912:THIMO RS03420
gene id: 765912:THIMO_RS03420
uniprot id: L0GS34
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

765912:THIMO RS15390
gene id: 765912:THIMO_RS15390
uniprot id: L0H2U5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
messages: Cell membrane
messages: Heterodimer of a large and a small subunit.

765912:THIMO RS01910
gene id: 765912:THIMO_RS01910
uniprot id: L0GTD0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

765912:THIMO RS13665
gene id: 765912:THIMO_RS13665
uniprot id: L0H030
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

765912:THIMO RS06620
gene id: 765912:THIMO_RS06620
uniprot id: L0GXS1
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

765912:THIMO RS01465
gene id: 765912:THIMO_RS01465
uniprot id: L0GV48
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

765912:THIMO RS03670
gene id: 765912:THIMO_RS03670
uniprot id: L0GS78
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

765912:THIMO RS14450
gene id: 765912:THIMO_RS14450
uniprot id: L0H0Y9
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS00605
gene id: 765912:THIMO_RS00605
uniprot id: L0GSQ4
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS07080
gene id: 765912:THIMO_RS07080
uniprot id: L0GY85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

765912:THIMO RS14870
gene id: 765912:THIMO_RS14870
uniprot id: L0GYG2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

765912:THIMO RS09240
gene id: 765912:THIMO_RS09240
uniprot id: L0GXZ6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

765912:THIMO RS07815
gene id: 765912:THIMO_RS07815
uniprot id: L0GYM1
names: Similarity
messages: Belongs to the WrbA family.

765912:THIMO RS01265
gene id: 765912:THIMO_RS01265
uniprot id: L0GV03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

765912:THIMO RS13725
gene id: 765912:THIMO_RS13725
uniprot id: L0H1W7
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

765912:THIMO RS11240
gene id: 765912:THIMO_RS11240
uniprot id: L0GYQ9
names: Similarity
names: Subunit
messages: Belongs to the complex I 75 kDa subunit family.
messages: Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex.

765912:THIMO RS07125
gene id: 765912:THIMO_RS07125
uniprot id: L0GWB2
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.

765912:THIMO RS04595
gene id: 765912:THIMO_RS04595
uniprot id: L0GWV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

765912:THIMO RS13535
gene id: 765912:THIMO_RS13535
uniprot id: L0H1N8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

765912:THIMO RS15845
gene id: 765912:THIMO_RS15845
uniprot id: L0H2Y7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

765912:THIMO RS03185
gene id: 765912:THIMO_RS03185
uniprot id: L0GVX4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS00440
gene id: 765912:THIMO_RS00440
uniprot id: L0GQF4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS03150
gene id: 765912:THIMO_RS03150
uniprot id: L0GUK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

765912:THIMO RS00895
gene id: 765912:THIMO_RS00895
uniprot id: L0GQP6
names: Function
names: Similarity
messages: Belongs to the Dus family. DusB subfamily.
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

765912:THIMO RS18405
gene id: 765912:THIMO_RS18405
uniprot id: L0H1Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane
messages: Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.

765912:THIMO RS06040
gene id: 765912:THIMO_RS06040
uniprot id: L0GVR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 1 family.
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

765912:THIMO RS15455
gene id: 765912:THIMO_RS15455
uniprot id: L0H139
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. NifB family.
messages: Involved in the biosynthesis of the iron-molybdenum cofactor (FeMo-co or M-cluster) found in the dinitrogenase enzyme of the nitrogenase complex in nitrogen-fixing microorganisms. NifB catalyzes the crucial step of radical SAM-dependent carbide insertion that occurs concomitant with the insertion of a 9th sulfur and the rearrangement/coupling of two [4Fe-4S] clusters into a [8Fe-9S-C] cluster, the precursor to the M-cluster.

765912:THIMO RS11105
gene id: 765912:THIMO_RS11105
uniprot id: L0H0B3
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS05260
gene id: 765912:THIMO_RS05260
uniprot id: L0GVP2
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

765912:THIMO RS02125
gene id: 765912:THIMO_RS02125
uniprot id: L0GU14
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

765912:THIMO RS14410
gene id: 765912:THIMO_RS14410
uniprot id: L0H2A3
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily.
messages: Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.

765912:THIMO RS16230
gene id: 765912:THIMO_RS16230
uniprot id: L0H345
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

765912:THIMO RS08920
gene id: 765912:THIMO_RS08920
uniprot id: L0GV54
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M15D family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.

765912:THIMO RS08785
gene id: 765912:THIMO_RS08785
uniprot id: L0GYZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter family.
messages: Membrane

765912:THIMO RS05130
gene id: 765912:THIMO_RS05130
uniprot id: L0GVL6
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

765912:THIMO RS00415
gene id: 765912:THIMO_RS00415
uniprot id: L0GQE1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

765912:THIMO RS13545
gene id: 765912:THIMO_RS13545
uniprot id: L0H0G5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

765912:THIMO RS01255
gene id: 765912:THIMO_RS01255
uniprot id: U3GM62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

765912:THIMO RS09740
gene id: 765912:THIMO_RS09740
uniprot id: L0GY91
names: Function
names: Similarity
messages: Belongs to the Fe(2+)-trafficking protein family.
messages: Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.

765912:THIMO RS16550
gene id: 765912:THIMO_RS16550
uniprot id: L0GZF6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

765912:THIMO RS00850
gene id: 765912:THIMO_RS00850
uniprot id: L0GUS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

765912:THIMO RS17375
gene id: 765912:THIMO_RS17375
uniprot id: L0H3Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

765912:THIMO RS09915
gene id: 765912:THIMO_RS09915
uniprot id: L0GZS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

765912:THIMO RS06230
gene id: 765912:THIMO_RS06230
uniprot id: L0GTL8
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

765912:THIMO RS00745
gene id: 765912:THIMO_RS00745
uniprot id: L0GUQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

765912:THIMO RS00175
gene id: 765912:THIMO_RS00175
uniprot id: L0GSY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

765912:THIMO RS13260
gene id: 765912:THIMO_RS13260
uniprot id: L0H0C1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

765912:THIMO RS17515
gene id: 765912:THIMO_RS17515
uniprot id: L0H2Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

765912:THIMO RS01160
gene id: 765912:THIMO_RS01160
uniprot id: L0GQU6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

765912:THIMO RS14140
gene id: 765912:THIMO_RS14140
uniprot id: L0H251
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

765912:THIMO RS01360
gene id: 765912:THIMO_RS01360
uniprot id: U3GM65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

765912:THIMO RS07265
gene id: 765912:THIMO_RS07265
uniprot id: L0GYB7
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

765912:THIMO RS08795
gene id: 765912:THIMO_RS08795
uniprot id: L0GXQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

765912:THIMO RS11415
gene id: 765912:THIMO_RS11415
uniprot id: L0GWJ0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
messages: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

765912:THIMO RS10480
gene id: 765912:THIMO_RS10480
uniprot id: L0H029
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

765912:THIMO RS08515
gene id: 765912:THIMO_RS08515
uniprot id: L0GZ22
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

765912:THIMO RS10610
gene id: 765912:THIMO_RS10610
uniprot id: L0GYS0
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

765912:THIMO RS11500
gene id: 765912:THIMO_RS11500
uniprot id: L0GYU7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

765912:THIMO RS00325
gene id: 765912:THIMO_RS00325
uniprot id: L0GUA1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

765912:THIMO RS16715
gene id: 765912:THIMO_RS16715
uniprot id: L0H1R5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

765912:THIMO RS15435
gene id: 765912:THIMO_RS15435
uniprot id: L0GYR7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-101 inactivates the nitrogenase reductase and regulates nitrogenase activity.

765912:THIMO RS05895
gene id: 765912:THIMO_RS05895
uniprot id: L0GW30
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

765912:THIMO RS07025
gene id: 765912:THIMO_RS07025
uniprot id: L0GU15
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

765912:THIMO RS10650
gene id: 765912:THIMO_RS10650
uniprot id: L0H032
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

765912:THIMO RS13460
gene id: 765912:THIMO_RS13460
uniprot id: L0H000
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

765912:THIMO RS10700
gene id: 765912:THIMO_RS10700
uniprot id: L0H047
names: Similarity
messages: Belongs to the Nudix hydrolase family.

765912:THIMO RS14765
gene id: 765912:THIMO_RS14765
uniprot id: L0H155
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

765912:THIMO RS13445
gene id: 765912:THIMO_RS13445
uniprot id: L0GXQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

765912:THIMO RS01715
gene id: 765912:THIMO_RS01715
uniprot id: L0GV98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

765912:THIMO RS15920
gene id: 765912:THIMO_RS15920
uniprot id: L0H2Z9
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

765912:THIMO RS05510
gene id: 765912:THIMO_RS05510
uniprot id: L0GT55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

765912:THIMO RS15900
gene id: 765912:THIMO_RS15900
uniprot id: L0H1D5
names: Function
names: Similarity
messages: Belongs to the RuBisCO large chain family. Type II subfamily.
messages: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.

765912:THIMO RS14285
gene id: 765912:THIMO_RS14285
uniprot id: L0H279
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ChlB/BchB/BchZ family.
messages: Chlorophyllide reductase is composed of three subunits; BchX, BchY and BchZ. Forms a heterodimer of one BchY and one BchZ subunit.
messages: Converts chlorophylls (Chl) into bacteriochlorophylls (BChl) by reducing ring B of the tetrapyrrole.

765912:THIMO RS12670
gene id: 765912:THIMO_RS12670
uniprot id: L0H162
names: Similarity
messages: Belongs to the TrpF family.

765912:THIMO RS17315
gene id: 765912:THIMO_RS17315
uniprot id: L0H238
names: Similarity
messages: Belongs to the NifX/NifY family.

765912:THIMO RS04395
gene id: 765912:THIMO_RS04395
uniprot id: L0GSL1
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

765912:THIMO RS03375
gene id: 765912:THIMO_RS03375
uniprot id: L0GW71
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

765912:THIMO RS08020
gene id: 765912:THIMO_RS08020
uniprot id: L0GYR4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

765912:THIMO RS09355
gene id: 765912:THIMO_RS09355
uniprot id: L0GZB6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

765912:THIMO RS12660
gene id: 765912:THIMO_RS12660
uniprot id: L0GX74
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

765912:THIMO RS13485
gene id: 765912:THIMO_RS13485
uniprot id: L0H1M9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

765912:THIMO RS11400
gene id: 765912:THIMO_RS11400
uniprot id: L0H0F8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

765912:THIMO RS10230
gene id: 765912:THIMO_RS10230
uniprot id: L0GYI5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the high-potential iron-sulfur protein (HiPIP) family.
messages: Homodimer.
messages: Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria.

765912:THIMO RS13635
gene id: 765912:THIMO_RS13635
uniprot id: L0H1Q0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

765912:THIMO RS02160
gene id: 765912:THIMO_RS02160
uniprot id: L0GVI4
names: Similarity
messages: Belongs to the RecJ family.

765912:THIMO RS06435
gene id: 765912:THIMO_RS06435
uniprot id: L0GTQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

765912:THIMO RS14885
gene id: 765912:THIMO_RS14885
uniprot id: L0H0S1
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

765912:THIMO RS15805
gene id: 765912:THIMO_RS15805
uniprot id: L0H2X8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

765912:THIMO RS04210
gene id: 765912:THIMO_RS04210
uniprot id: L0GSI2
names: Similarity
messages: Belongs to the RuBisCO large chain family.

765912:THIMO RS00865
gene id: 765912:THIMO_RS00865
uniprot id: L0GTB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbD subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.

765912:THIMO RS10215
gene id: 765912:THIMO_RS10215
uniprot id: L0GZY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

765912:THIMO RS02210
gene id: 765912:THIMO_RS02210
uniprot id: L0GVD1
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

765912:THIMO RS14475
gene id: 765912:THIMO_RS14475
uniprot id: L0H0Z4
names: Similarity
messages: Belongs to the phosphohexose mutase family.

765912:THIMO RS11065
gene id: 765912:THIMO_RS11065
uniprot id: L0GYZ6
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.
messages: Belongs to the RecC family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

765912:THIMO RS15590
gene id: 765912:THIMO_RS15590
uniprot id: L0H2Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

765912:THIMO RS09850
gene id: 765912:THIMO_RS09850
uniprot id: L0GVM0
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

765912:THIMO RS15995
gene id: 765912:THIMO_RS15995
uniprot id: L0H1F0
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS08740
gene id: 765912:THIMO_RS08740
uniprot id: L0GX91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

765912:THIMO RS11375
gene id: 765912:THIMO_RS11375
uniprot id: L0H0F4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

765912:THIMO RS12780
gene id: 765912:THIMO_RS12780
uniprot id: L0GZJ7
names: Similarity
messages: Belongs to the citrate synthase family.

765912:THIMO RS00200
gene id: 765912:THIMO_RS00200
uniprot id: L0GSZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

765912:THIMO RS13675
gene id: 765912:THIMO_RS13675
uniprot id: L0GXU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

765912:THIMO RS03190
gene id: 765912:THIMO_RS03190
uniprot id: L0GU66
names: Similarity
messages: Belongs to the phosphoribulokinase family.

765912:THIMO RS03505
gene id: 765912:THIMO_RS03505
uniprot id: L0GW23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

765912:THIMO RS08125
gene id: 765912:THIMO_RS08125
uniprot id: L0GYP4
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

765912:THIMO RS04585
gene id: 765912:THIMO_RS04585
uniprot id: L0GVC9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

765912:THIMO RS12400
gene id: 765912:THIMO_RS12400
uniprot id: L0GZC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

765912:THIMO RS17410
gene id: 765912:THIMO_RS17410
uniprot id: L0H261
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

765912:THIMO RS04075
gene id: 765912:THIMO_RS04075
uniprot id: L0GV32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Cytoplasm

765912:THIMO RS04965
gene id: 765912:THIMO_RS04965
uniprot id: L0GWV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
messages: Cell inner membrane

765912:THIMO RS03055
gene id: 765912:THIMO_RS03055
uniprot id: L0GRV5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

765912:THIMO RS12585
gene id: 765912:THIMO_RS12585
uniprot id: L0GX59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

765912:THIMO RS00750
gene id: 765912:THIMO_RS00750
uniprot id: L0GUJ9
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

765912:THIMO RS14745
gene id: 765912:THIMO_RS14745
uniprot id: L0GYD8
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

765912:THIMO RS08100
gene id: 765912:THIMO_RS08100
uniprot id: L0GYN9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

765912:THIMO RS00885
gene id: 765912:THIMO_RS00885
uniprot id: L0GSU5
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

765912:THIMO RS05085
gene id: 765912:THIMO_RS05085
uniprot id: L0GSX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0382 family.
messages: Membrane

765912:THIMO RS03040
gene id: 765912:THIMO_RS03040
uniprot id: L0GVV1
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS01780
gene id: 765912:THIMO_RS01780
uniprot id: L0GTU8
names: Cofactor
names: Similarity
messages: Belongs to the RimK family.
messages: Binds 2 magnesium or manganese ions per subunit.

765912:THIMO RS17080
gene id: 765912:THIMO_RS17080
uniprot id: L0H3T6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

765912:THIMO RS03570
gene id: 765912:THIMO_RS03570
uniprot id: L0GS62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

765912:THIMO RS10840
gene id: 765912:THIMO_RS10840
uniprot id: L0GYJ6
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

765912:THIMO RS00890
gene id: 765912:THIMO_RS00890
uniprot id: L0GTC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

765912:THIMO RS03630
gene id: 765912:THIMO_RS03630
uniprot id: L0GW43
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

765912:THIMO RS10030
gene id: 765912:THIMO_RS10030
uniprot id: L0GYE4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS14490
gene id: 765912:THIMO_RS14490
uniprot id: L0H257
names: Cofactor
messages: Binds 1 Mg(2+) ion per subunit.

765912:THIMO RS15120
gene id: 765912:THIMO_RS15120
uniprot id: L0H1C7
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

765912:THIMO RS08550
gene id: 765912:THIMO_RS08550
uniprot id: L0GX64
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS01775
gene id: 765912:THIMO_RS01775
uniprot id: L0GYB5
names: Similarity
messages: Belongs to the transposase 8 family.

765912:THIMO RS14815
gene id: 765912:THIMO_RS14815
uniprot id: L0H166
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsL family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Membrane
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

765912:THIMO RS06630
gene id: 765912:THIMO_RS06630
uniprot id: L0GWH2
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the WrbA family.
messages: Binds 1 FMN per monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS03510
gene id: 765912:THIMO_RS03510
uniprot id: L0GUB7
names: Function
names: Similarity
messages: Belongs to the LpxB family.
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

765912:THIMO RS12785
gene id: 765912:THIMO_RS12785
uniprot id: L0H001
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
messages: Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.
messages: Homotetramer; dimer of dimers.
messages: Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate.

765912:THIMO RS01520
gene id: 765912:THIMO_RS01520
uniprot id: L0GUZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISPR system Cmr5 family.
messages: Cytoplasm

765912:THIMO RS13195
gene id: 765912:THIMO_RS13195
uniprot id: L0GXK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

765912:THIMO RS15605
gene id: 765912:THIMO_RS15605
uniprot id: L0H1N0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

765912:THIMO RS08405
gene id: 765912:THIMO_RS08405
uniprot id: L0GYT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

765912:THIMO RS17450
gene id: 765912:THIMO_RS17450
uniprot id: L0H403
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecB family.
messages: Cytoplasm
messages: Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.
messages: One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.

765912:THIMO RS03730
gene id: 765912:THIMO_RS03730
uniprot id: L0GUE6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
messages: Cell membrane
messages: Heterodimer of a large and a small subunit.

765912:THIMO RS14750
gene id: 765912:THIMO_RS14750
uniprot id: L0H2H5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

765912:THIMO RS04575
gene id: 765912:THIMO_RS04575
uniprot id: L0GWP0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

765912:THIMO RS03965
gene id: 765912:THIMO_RS03965
uniprot id: L0GWI5
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS10370
gene id: 765912:THIMO_RS10370
uniprot id: L0GYL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell inner membrane
messages: Membrane

765912:THIMO RS10440
gene id: 765912:THIMO_RS10440
uniprot id: L0GY93
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS04145
gene id: 765912:THIMO_RS04145
uniprot id: L0GUM4
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

765912:THIMO RS13560
gene id: 765912:THIMO_RS13560
uniprot id: L0H1P0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

765912:THIMO RS08710
gene id: 765912:THIMO_RS08710
uniprot id: L0GYY2
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

765912:THIMO RS14820
gene id: 765912:THIMO_RS14820
uniprot id: L0GYF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

765912:THIMO RS03645
gene id: 765912:THIMO_RS03645
uniprot id: L0GS74
names: Similarity
messages: Belongs to the RutC family.

765912:THIMO RS04560
gene id: 765912:THIMO_RS04560
uniprot id: L0GVC4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

765912:THIMO RS06670
gene id: 765912:THIMO_RS06670
uniprot id: L0GXT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the encapsulin family. Family 1 subfamily.
messages: Encapsulin nanocompartment

765912:THIMO RS03595
gene id: 765912:THIMO_RS03595
uniprot id: L0GS67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

765912:THIMO RS11965
gene id: 765912:THIMO_RS11965
uniprot id: L0GWU1
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

765912:THIMO RS06995
gene id: 765912:THIMO_RS06995
uniprot id: L0GWP7
names: Function
names: Similarity
messages: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
messages: Belongs to the Nudix hydrolase family. RppH subfamily.

765912:THIMO RS14785
gene id: 765912:THIMO_RS14785
uniprot id: L0H0P8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. FtsW subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell division.

765912:THIMO RS02855
gene id: 765912:THIMO_RS02855
uniprot id: L0GVW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

765912:THIMO RS02635
gene id: 765912:THIMO_RS02635
uniprot id: L0GUB3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

765912:THIMO RS16090
gene id: 765912:THIMO_RS16090
uniprot id: L0H325
names: Similarity
messages: Belongs to the UPF0434 family.

765912:THIMO RS05610
gene id: 765912:THIMO_RS05610
uniprot id: L0GTA2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

765912:THIMO RS13450
gene id: 765912:THIMO_RS13450
uniprot id: L0H1S8
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Tetramer of two alpha and two beta subunits.

765912:THIMO RS04050
gene id: 765912:THIMO_RS04050
uniprot id: L0GUK1
names: Similarity
messages: Belongs to the thioredoxin family.

765912:THIMO RS08115
gene id: 765912:THIMO_RS08115
uniprot id: L0GUR0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

765912:THIMO RS04425
gene id: 765912:THIMO_RS04425
uniprot id: L0GWS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CbiQ family.
messages: Membrane

765912:THIMO RS17100
gene id: 765912:THIMO_RS17100
uniprot id: L0GZS1
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

765912:THIMO RS09310
gene id: 765912:THIMO_RS09310
uniprot id: L0GXJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

765912:THIMO RS16605
gene id: 765912:THIMO_RS16605
uniprot id: L0H3I5
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS01005
gene id: 765912:THIMO_RS01005
uniprot id: L0GSW5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

765912:THIMO RS14495
gene id: 765912:THIMO_RS14495
uniprot id: L0H0I5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

765912:THIMO RS12700
gene id: 765912:THIMO_RS12700
uniprot id: L0GZI1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

765912:THIMO RS03590
gene id: 765912:THIMO_RS03590
uniprot id: L0GUT5
names: Similarity
messages: Belongs to the YggT family.

765912:THIMO RS13570
gene id: 765912:THIMO_RS13570
uniprot id: L0H0H0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

765912:THIMO RS09190
gene id: 765912:THIMO_RS09190
uniprot id: L0GXY6
names: Similarity
messages: Belongs to the DEAD box helicase family.

765912:THIMO RS14180
gene id: 765912:THIMO_RS14180
uniprot id: L0H0T8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Cell outer membrane
messages: Homodimer.
messages: Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids.

765912:THIMO RS12240
gene id: 765912:THIMO_RS12240
uniprot id: L0H0W5
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

765912:THIMO RS00210
gene id: 765912:THIMO_RS00210
uniprot id: L0GUD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP H family.
messages: Cell inner membrane
messages: Membrane

765912:THIMO RS06250
gene id: 765912:THIMO_RS06250
uniprot id: L0GW98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter family.
messages: Membrane

765912:THIMO RS02095
gene id: 765912:THIMO_RS02095
uniprot id: U3GK56
names: Similarity
messages: Belongs to the SCO1/2 family.

765912:THIMO RS03435
gene id: 765912:THIMO_RS03435
uniprot id: L0GUA4
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

765912:THIMO RS12570
gene id: 765912:THIMO_RS12570
uniprot id: L0H141
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS12770
gene id: 765912:THIMO_RS12770
uniprot id: L0H1C5
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS12050
gene id: 765912:THIMO_RS12050
uniprot id: L0GWV6
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS10110
gene id: 765912:THIMO_RS10110
uniprot id: L0GVS1
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

765912:THIMO RS07710
gene id: 765912:THIMO_RS07710
uniprot id: L0GUE1
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

765912:THIMO RS13625
gene id: 765912:THIMO_RS13625
uniprot id: L0GXT6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

765912:THIMO RS02145
gene id: 765912:THIMO_RS02145
uniprot id: L0GTI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

765912:THIMO RS15520
gene id: 765912:THIMO_RS15520
uniprot id: L0H2Q8
names: Function
names: Similarity
messages: Belongs to the Ap4A hydrolase family.
messages: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.

765912:THIMO RS00135
gene id: 765912:THIMO_RS00135
uniprot id: L0GUC5
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

765912:THIMO RS10920
gene id: 765912:THIMO_RS10920
uniprot id: L0GYK8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

765912:THIMO RS04415
gene id: 765912:THIMO_RS04415
uniprot id: L0GVA1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

765912:THIMO RS15130
gene id: 765912:THIMO_RS15130
uniprot id: L0H2P4
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

765912:THIMO RS01885
gene id: 765912:THIMO_RS01885
uniprot id: L0GTW8
names: Similarity
messages: Belongs to the RelE toxin family.

765912:THIMO RS13250
gene id: 765912:THIMO_RS13250
uniprot id: L0H1J3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Cell inner membrane
messages: Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins.
messages: Membrane

765912:THIMO RS18500
gene id: 765912:THIMO_RS18500
uniprot id: L0H2X0
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS07120
gene id: 765912:THIMO_RS07120
uniprot id: L0GY19
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.

765912:THIMO RS09445
gene id: 765912:THIMO_RS09445
uniprot id: L0GVF0
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS00525
gene id: 765912:THIMO_RS00525
uniprot id: L0GUG6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48 family. BepA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state.
messages: Periplasm

765912:THIMO RS02505
gene id: 765912:THIMO_RS02505
uniprot id: L0GRJ1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase E/G family. RNase E subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per homotetramer.
messages: Cell inner membrane
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation. Within the RNA degradosome, RNase E assembles into a homotetramer formed by a dimer of dimers.
messages: Cytoplasm
messages: Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs.

765912:THIMO RS17480
gene id: 765912:THIMO_RS17480
uniprot id: L0H3T3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.

765912:THIMO RS08030
gene id: 765912:THIMO_RS08030
uniprot id: L0GWX5
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

765912:THIMO RS05665
gene id: 765912:THIMO_RS05665
uniprot id: L0GXH3
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

765912:THIMO RS02795
gene id: 765912:THIMO_RS02795
uniprot id: L0GUE3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

765912:THIMO RS01975
gene id: 765912:THIMO_RS01975
uniprot id: L0GVF3
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

765912:THIMO RS14900
gene id: 765912:THIMO_RS14900
uniprot id: L0GYG6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

765912:THIMO RS17220
gene id: 765912:THIMO_RS17220
uniprot id: L0H2J8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

765912:THIMO RS01950
gene id: 765912:THIMO_RS01950
uniprot id: L0GVE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TamA family.
messages: Cell outer membrane
messages: Membrane

765912:THIMO RS15800
gene id: 765912:THIMO_RS15800
uniprot id: L0H333
names: Similarity
messages: Belongs to the disproportionating enzyme family.

765912:THIMO RS16545
gene id: 765912:THIMO_RS16545
uniprot id: L0H272
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

765912:THIMO RS02645
gene id: 765912:THIMO_RS02645
uniprot id: L0GVS5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

765912:THIMO RS04485
gene id: 765912:THIMO_RS04485
uniprot id: L0GWM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

765912:THIMO RS15825
gene id: 765912:THIMO_RS15825
uniprot id: L0H339
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS17175
gene id: 765912:THIMO_RS17175
uniprot id: L0GZT2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

765912:THIMO RS00020
gene id: 765912:THIMO_RS00020
uniprot id: L0GSV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

765912:THIMO RS02440
gene id: 765912:THIMO_RS02440
uniprot id: L0GTQ0
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
messages: Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the cytidylyltransferase family.
messages: In the N-terminal section; belongs to the carbohydrate kinase PfkB family.

765912:THIMO RS06420
gene id: 765912:THIMO_RS06420
uniprot id: L0GXN3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CcoP / FixP family.
messages: Binds 2 heme C groups per subunit.
messages: C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex.
messages: Cell inner membrane
messages: Component of the cbb3-type cytochrome c oxidase.

765912:THIMO RS02040
gene id: 765912:THIMO_RS02040
uniprot id: L0GRA9
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

765912:THIMO RS08905
gene id: 765912:THIMO_RS08905
uniprot id: L0GZ93
names: Similarity
messages: Belongs to the peptidase C56 family.

765912:THIMO RS14930
gene id: 765912:THIMO_RS14930
uniprot id: L0H2K7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

765912:THIMO RS16275
gene id: 765912:THIMO_RS16275
uniprot id: L0GZA9
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

765912:THIMO RS16730
gene id: 765912:THIMO_RS16730
uniprot id: L0H3L0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

765912:THIMO RS16720
gene id: 765912:THIMO_RS16720
uniprot id: L0H2A6
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

765912:THIMO RS17495
gene id: 765912:THIMO_RS17495
uniprot id: L0GZZ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

765912:THIMO RS08670
gene id: 765912:THIMO_RS08670
uniprot id: L0GZ46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

765912:THIMO RS14420
gene id: 765912:THIMO_RS14420
uniprot id: L0H0G8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

765912:THIMO RS06660
gene id: 765912:THIMO_RS06660
uniprot id: L0GTU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Homodimer.

765912:THIMO RS10400
gene id: 765912:THIMO_RS10400
uniprot id: L0GVW7
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

765912:THIMO RS12090
gene id: 765912:THIMO_RS12090
uniprot id: L0GZ56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Membrane

765912:THIMO RS04910
gene id: 765912:THIMO_RS04910
uniprot id: L0GX10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

765912:THIMO RS06295
gene id: 765912:THIMO_RS06295
uniprot id: L0GXK8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

765912:THIMO RS09245
gene id: 765912:THIMO_RS09245
uniprot id: L0GVB7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homohexamer.
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the CobB/CobQ family.
messages: Involved in acetate metabolism.
messages: The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site.

765912:THIMO RS14775
gene id: 765912:THIMO_RS14775
uniprot id: L0H2I0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

765912:THIMO RS14620
gene id: 765912:THIMO_RS14620
uniprot id: L0H2E8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

765912:THIMO RS17385
gene id: 765912:THIMO_RS17385
uniprot id: L0H256
names: Similarity
messages: Belongs to the universal stress protein A family.

765912:THIMO RS16615
gene id: 765912:THIMO_RS16615
uniprot id: L0H1P8
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

765912:THIMO RS11440
gene id: 765912:THIMO_RS11440
uniprot id: L0GWJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

765912:THIMO RS00455
gene id: 765912:THIMO_RS00455
uniprot id: L0GSM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

765912:THIMO RS16350
gene id: 765912:THIMO_RS16350
uniprot id: L0H236
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

765912:THIMO RS05125
gene id: 765912:THIMO_RS05125
uniprot id: L0GV65
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

765912:THIMO RS10845
gene id: 765912:THIMO_RS10845
uniprot id: L0GYV9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

765912:THIMO RS10465
gene id: 765912:THIMO_RS10465
uniprot id: L0GY98
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

765912:THIMO RS11475
gene id: 765912:THIMO_RS11475
uniprot id: L0H0H3
names: Similarity
messages: Belongs to the fructosamine kinase family.

765912:THIMO RS13165
gene id: 765912:THIMO_RS13165
uniprot id: L0GZU8
names: Function
names: Similarity
messages: Belongs to the sigma-54 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

765912:THIMO RS02025
gene id: 765912:THIMO_RS02025
uniprot id: L0GV95
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

765912:THIMO RS06655
gene id: 765912:THIMO_RS06655
uniprot id: L0GWH6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

765912:THIMO RS17140
gene id: 765912:THIMO_RS17140
uniprot id: L0H200
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

765912:THIMO RS03255
gene id: 765912:THIMO_RS03255
uniprot id: L0GW50
names: Function
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.
messages: E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

765912:THIMO RS05250
gene id: 765912:THIMO_RS05250
uniprot id: L0GX07
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

765912:THIMO RS13240
gene id: 765912:THIMO_RS13240
uniprot id: L0GXL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

765912:THIMO RS15400
gene id: 765912:THIMO_RS15400
uniprot id: L0H129
names: Similarity
messages: Belongs to the peptidase A31 family.

765912:THIMO RS17500
gene id: 765912:THIMO_RS17500
uniprot id: L0H411
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS14250
gene id: 765912:THIMO_RS14250
uniprot id: U3GK57
names: Function
names: PTM
messages: Binds 4 heme groups per subunit.
messages: The reaction center of purple bacteria contains a tightly bound cytochrome molecule which re-reduces the photo oxidized primary electron donor.

765912:THIMO RS08130
gene id: 765912:THIMO_RS08130
uniprot id: L0GWZ7
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

765912:THIMO RS13515
gene id: 765912:THIMO_RS13515
uniprot id: L0H006
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

765912:THIMO RS05745
gene id: 765912:THIMO_RS05745
uniprot id: L0GXB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PsiE family.
messages: Cell inner membrane
messages: Membrane

765912:THIMO RS07595
gene id: 765912:THIMO_RS07595
uniprot id: L0GWL5
names: Similarity
messages: Belongs to the FPG family.

765912:THIMO RS05065
gene id: 765912:THIMO_RS05065
uniprot id: L0GX35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
messages: Cytoplasm
messages: Homodimer.

765912:THIMO RS07235
gene id: 765912:THIMO_RS07235
uniprot id: L0GWU0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

765912:THIMO RS10545
gene id: 765912:THIMO_RS10545
uniprot id: L0H045
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

765912:THIMO RS00375
gene id: 765912:THIMO_RS00375
uniprot id: L0GUB2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

765912:THIMO RS07805
gene id: 765912:THIMO_RS07805
uniprot id: L0GX55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

765912:THIMO RS07090
gene id: 765912:THIMO_RS07090
uniprot id: L0GWA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbC subfamily.
messages: Periplasm
messages: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process.

765912:THIMO RS02520
gene id: 765912:THIMO_RS02520
uniprot id: L0GTR7
names: Similarity
messages: Belongs to the peptidase S49 family.

765912:THIMO RS15465
gene id: 765912:THIMO_RS15465
uniprot id: L0GYS2
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

765912:THIMO RS09990
gene id: 765912:THIMO_RS09990
uniprot id: L0GZT7
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS14780
gene id: 765912:THIMO_RS14780
uniprot id: L0H2B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).

765912:THIMO RS08675
gene id: 765912:THIMO_RS08675
uniprot id: L0GYX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

765912:THIMO RS04490
gene id: 765912:THIMO_RS04490
uniprot id: L0GUU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

765912:THIMO RS12620
gene id: 765912:THIMO_RS12620
uniprot id: L0H151
names: Caution
names: Function
names: Similarity
messages: Belongs to the precorrin methyltransferase family.
messages: In the C-terminal section; belongs to the precorrin methyltransferase family.
messages: In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.

765912:THIMO RS07715
gene id: 765912:THIMO_RS07715
uniprot id: L0GYK3
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
messages: Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.

765912:THIMO RS09690
gene id: 765912:THIMO_RS09690
uniprot id: L0GY86
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

765912:THIMO RS11055
gene id: 765912:THIMO_RS11055
uniprot id: L0H0A4
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.
messages: Belongs to the RecD family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

765912:THIMO RS07845
gene id: 765912:THIMO_RS07845
uniprot id: L0GYG0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

765912:THIMO RS13215
gene id: 765912:THIMO_RS13215
uniprot id: L0GXL0
names: Function
names: Similarity
messages: Belongs to the UbiT family.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Likely functions as an accessory factor.

765912:THIMO RS00940
gene id: 765912:THIMO_RS00940
uniprot id: L0GTD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

765912:THIMO RS11445
gene id: 765912:THIMO_RS11445
uniprot id: L0H0L6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

765912:THIMO RS12385
gene id: 765912:THIMO_RS12385
uniprot id: L0GX17
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

765912:THIMO RS04495
gene id: 765912:THIMO_RS04495
uniprot id: L0GVB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

765912:THIMO RS11135
gene id: 765912:THIMO_RS11135
uniprot id: L0GYP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.
messages: Cytoplasm
messages: Specifically methylates the ribose of guanosine 2251 in 23S rRNA.

765912:THIMO RS02500
gene id: 765912:THIMO_RS02500
uniprot id: L0GU91
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

765912:THIMO RS08025
gene id: 765912:THIMO_RS08025
uniprot id: L0GYJ8
names: Function
names: Similarity
messages: Belongs to the MoaB/Mog family.
messages: May be involved in the biosynthesis of molybdopterin.

765912:THIMO RS14005
gene id: 765912:THIMO_RS14005
uniprot id: L0H0Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inorganic carbon transporter (TC 9.A.2) DabB family.
messages: Cell membrane
messages: Forms a complex with DabA.
messages: Membrane
messages: Part of an energy-coupled inorganic carbon pump.

765912:THIMO RS11625
gene id: 765912:THIMO_RS11625
uniprot id: L0H0K3
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

765912:THIMO RS00765
gene id: 765912:THIMO_RS00765
uniprot id: L0GQM0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

765912:THIMO RS06095
gene id: 765912:THIMO_RS06095
uniprot id: L0GW69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

765912:THIMO RS06100
gene id: 765912:THIMO_RS06100
uniprot id: L0GTJ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

765912:THIMO RS09455
gene id: 765912:THIMO_RS09455
uniprot id: L0GZE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

765912:THIMO RS02305
gene id: 765912:THIMO_RS02305
uniprot id: L0GVL8
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

765912:THIMO RS01830
gene id: 765912:THIMO_RS01830
uniprot id: U3GKH4
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

765912:THIMO RS05680
gene id: 765912:THIMO_RS05680
uniprot id: L0GVK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

765912:THIMO RS11385
gene id: 765912:THIMO_RS11385
uniprot id: L0GZ55
names: Similarity
messages: Belongs to the fabD family.

765912:THIMO RS06385
gene id: 765912:THIMO_RS06385
uniprot id: L0GTP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoS subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.

765912:THIMO RS01150
gene id: 765912:THIMO_RS01150
uniprot id: L0GSY7
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

765912:THIMO RS05740
gene id: 765912:THIMO_RS05740
uniprot id: L0GXI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

765912:THIMO RS13615
gene id: 765912:THIMO_RS13615
uniprot id: L0H024
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

765912:THIMO RS08555
gene id: 765912:THIMO_RS08555
uniprot id: L0GXK4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

765912:THIMO RS06695
gene id: 765912:THIMO_RS06695
uniprot id: L0GY06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dsrC/tusE family.
messages: Cytoplasm
messages: Part of a sulfur-relay system.

765912:THIMO RS17345
gene id: 765912:THIMO_RS17345
uniprot id: L0H2M1
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
messages: Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.

765912:THIMO RS11140
gene id: 765912:THIMO_RS11140
uniprot id: L0GZ10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

765912:THIMO RS13585
gene id: 765912:THIMO_RS13585
uniprot id: L0H1P1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

765912:THIMO RS02665
gene id: 765912:THIMO_RS02665
uniprot id: L0GRL9
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

765912:THIMO RS13690
gene id: 765912:THIMO_RS13690
uniprot id: L0H034
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

765912:THIMO RS12460
gene id: 765912:THIMO_RS12460
uniprot id: L0H167
names: Similarity
messages: Belongs to the peptidase U62 family.

765912:THIMO RS00215
gene id: 765912:THIMO_RS00215
uniprot id: L0GU77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP I family.
messages: Cell inner membrane
messages: Membrane

765912:THIMO RS17210
gene id: 765912:THIMO_RS17210
uniprot id: L0H3M8
names: Similarity
messages: Belongs to the peptidase M16 family.

765912:THIMO RS00360
gene id: 765912:THIMO_RS00360
uniprot id: L0GT19
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

765912:THIMO RS00330
gene id: 765912:THIMO_RS00330
uniprot id: L0GSH9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

765912:THIMO RS01145
gene id: 765912:THIMO_RS01145
uniprot id: L0GUR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Heterodimer of an alpha and a beta chain.
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

765912:THIMO RS03225
gene id: 765912:THIMO_RS03225
uniprot id: L0GRZ7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

765912:THIMO RS13775
gene id: 765912:THIMO_RS13775
uniprot id: L0H1X9
names: Similarity
messages: Belongs to the pyruvate kinase family.

765912:THIMO RS14895
gene id: 765912:THIMO_RS14895
uniprot id: L0H180
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

765912:THIMO RS09205
gene id: 765912:THIMO_RS09205
uniprot id: L0GZ84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioester dehydratase family. FabA subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.

765912:THIMO RS11210
gene id: 765912:THIMO_RS11210
uniprot id: L0H0C9
names: Similarity
messages: Belongs to the UPF0166 family.

765912:THIMO RS01735
gene id: 765912:THIMO_RS01735
uniprot id: L0GR51
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS09635
gene id: 765912:THIMO_RS09635
uniprot id: L0GZM7
names: Similarity
messages: Belongs to the glycosyl hydrolase 100 family.

765912:THIMO RS18055
gene id: 765912:THIMO_RS18055
uniprot id: L0GT62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

765912:THIMO RS03300
gene id: 765912:THIMO_RS03300
uniprot id: L0GW59
names: Similarity
messages: Belongs to the GSP E family.

765912:THIMO RS02335
gene id: 765912:THIMO_RS02335
uniprot id: L0GVF5
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

765912:THIMO RS15155
gene id: 765912:THIMO_RS15155
uniprot id: L0H2Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

765912:THIMO RS07960
gene id: 765912:THIMO_RS07960
uniprot id: L0GX89
names: Similarity
messages: Belongs to the transposase 8 family.

765912:THIMO RS16480
gene id: 765912:THIMO_RS16480
uniprot id: L0H1M3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

765912:THIMO RS13465
gene id: 765912:THIMO_RS13465
uniprot id: L0H0F1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

765912:THIMO RS16195
gene id: 765912:THIMO_RS16195
uniprot id: L0GZ98
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

765912:THIMO RS00505
gene id: 765912:THIMO_RS00505
uniprot id: L0GSN2
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
messages: Belongs to the biotin--protein ligase family.

765912:THIMO RS11495
gene id: 765912:THIMO_RS11495
uniprot id: L0H0H7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

765912:THIMO RS13455
gene id: 765912:THIMO_RS13455
uniprot id: L0H1M4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

765912:THIMO RS11835
gene id: 765912:THIMO_RS11835
uniprot id: L0H0U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

765912:THIMO RS12195
gene id: 765912:THIMO_RS12195
uniprot id: L0GZ80
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

765912:THIMO RS09210
gene id: 765912:THIMO_RS09210
uniprot id: L0GXG9
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS00275
gene id: 765912:THIMO_RS00275
uniprot id: L0GT04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell membrane
messages: Membrane

765912:THIMO RS02990
gene id: 765912:THIMO_RS02990
uniprot id: L0GVT5
names: Subcellular Location Annotation
messages: Cell inner membrane

765912:THIMO RS01815
gene id: 765912:THIMO_RS01815
uniprot id: L0GR65
names: Similarity
messages: Belongs to the CFA/CMAS family.

765912:THIMO RS11945
gene id: 765912:THIMO_RS11945
uniprot id: L0H0W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

765912:THIMO RS02810
gene id: 765912:THIMO_RS02810
uniprot id: L0GVN9
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

765912:THIMO RS12190
gene id: 765912:THIMO_RS12190
uniprot id: L0H0V5
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

765912:THIMO RS11600
gene id: 765912:THIMO_RS11600
uniprot id: L0H0J9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

765912:THIMO RS02445
gene id: 765912:THIMO_RS02445
uniprot id: L0GU80
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: Homotetramer.
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

765912:THIMO RS14055
gene id: 765912:THIMO_RS14055
uniprot id: L0H0R2
names: Similarity
messages: Belongs to the bacterioferritin family.

765912:THIMO RS10460
gene id: 765912:THIMO_RS10460
uniprot id: L0GZX7
names: Similarity
messages: Belongs to the peptidase S41A family.

765912:THIMO RS12625
gene id: 765912:THIMO_RS12625
uniprot id: L0GZG8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

765912:THIMO RS13705
gene id: 765912:THIMO_RS13705
uniprot id: L0H027
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

765912:THIMO RS08620
gene id: 765912:THIMO_RS08620
uniprot id: L0GYW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

765912:THIMO RS10820
gene id: 765912:THIMO_RS10820
uniprot id: L0GYV6
names: Similarity
messages: Belongs to the V-ATPase D subunit family.

765912:THIMO RS11655
gene id: 765912:THIMO_RS11655
uniprot id: L0GYX5
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

765912:THIMO RS09055
gene id: 765912:THIMO_RS09055
uniprot id: L0GZC4
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.

765912:THIMO RS04605
gene id: 765912:THIMO_RS04605
uniprot id: L0GUX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

765912:THIMO RS08140
gene id: 765912:THIMO_RS08140
uniprot id: L0GUR4
names: Similarity
messages: Belongs to the HupF/HypC family.

765912:THIMO RS02820
gene id: 765912:THIMO_RS02820
uniprot id: L0GUE8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the complex I 75 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

765912:THIMO RS10455
gene id: 765912:THIMO_RS10455
uniprot id: L0H025
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.

765912:THIMO RS16970
gene id: 765912:THIMO_RS16970
uniprot id: L0H3R3
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS12430
gene id: 765912:THIMO_RS12430
uniprot id: L0GX27
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

765912:THIMO RS14045
gene id: 765912:THIMO_RS14045
uniprot id: L0H1W8
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

765912:THIMO RS14150
gene id: 765912:THIMO_RS14150
uniprot id: L0H0B4
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS06470
gene id: 765912:THIMO_RS06470
uniprot id: L0GXP1
names: Function
names: Similarity
messages: Belongs to the CcmH/CycL/Ccl2/NrfF family.
messages: Possible subunit of a heme lyase.

765912:THIMO RS13875
gene id: 765912:THIMO_RS13875
uniprot id: L0H062
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

765912:THIMO RS13730
gene id: 765912:THIMO_RS13730
uniprot id: L0H1R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

765912:THIMO RS14455
gene id: 765912:THIMO_RS14455
uniprot id: L0GY83
names: Similarity
messages: Belongs to the 6-phosphogluconate dehydrogenase family.

765912:THIMO RS06515
gene id: 765912:THIMO_RS06515
uniprot id: L0GXX3
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

765912:THIMO RS03200
gene id: 765912:THIMO_RS03200
uniprot id: L0GRZ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

765912:THIMO RS00380
gene id: 765912:THIMO_RS00380
uniprot id: L0GSI9
names: Similarity
messages: Belongs to the citrate synthase family.

765912:THIMO RS14810
gene id: 765912:THIMO_RS14810
uniprot id: L0H0Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family. FtsI subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.
messages: Cell inner membrane

765912:THIMO RS17115
gene id: 765912:THIMO_RS17115
uniprot id: L0H1Z5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA gyrase inhibitor YacG family.
messages: Binds 1 zinc ion.
messages: Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
messages: Interacts with GyrB.

765912:THIMO RS12450
gene id: 765912:THIMO_RS12450
uniprot id: L0GZT3
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

765912:THIMO RS00645
gene id: 765912:THIMO_RS00645
uniprot id: L0GUP0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS02815
gene id: 765912:THIMO_RS02815
uniprot id: L0GTX1
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

765912:THIMO RS05495
gene id: 765912:THIMO_RS05495
uniprot id: L0GX57
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS11485
gene id: 765912:THIMO_RS11485
uniprot id: L0GWK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

765912:THIMO RS15365
gene id: 765912:THIMO_RS15365
uniprot id: L0H2U0
names: Similarity
messages: Belongs to the NifZ family.

765912:THIMO RS14385
gene id: 765912:THIMO_RS14385
uniprot id: L0GZV7
names: Similarity
messages: Belongs to the Mg-chelatase subunit H family.

765912:THIMO RS10410
gene id: 765912:THIMO_RS10410
uniprot id: L0GZW7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
messages: One is catalytic and the other provides a structural contribution.

765912:THIMO RS10825
gene id: 765912:THIMO_RS10825
uniprot id: L0GW88
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.

765912:THIMO RS11650
gene id: 765912:THIMO_RS11650
uniprot id: L0H0K8
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Belongs to the DNA photolyase family.
messages: Binds 1 FAD per subunit.

765912:THIMO RS07735
gene id: 765912:THIMO_RS07735
uniprot id: L0GUE5
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

765912:THIMO RS11510
gene id: 765912:THIMO_RS11510
uniprot id: L0GWK9
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS16705
gene id: 765912:THIMO_RS16705
uniprot id: L0H3K5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

765912:THIMO RS07040
gene id: 765912:THIMO_RS07040
uniprot id: L0GW94
names: Similarity
messages: Belongs to the BolA/IbaG family.

765912:THIMO RS16080
gene id: 765912:THIMO_RS16080
uniprot id: L0GZ75
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS17085
gene id: 765912:THIMO_RS17085
uniprot id: L0H3K4
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

765912:THIMO RS13100
gene id: 765912:THIMO_RS13100
uniprot id: L0GXG0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

765912:THIMO RS10605
gene id: 765912:THIMO_RS10605
uniprot id: L0GYE2
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

765912:THIMO RS17240
gene id: 765912:THIMO_RS17240
uniprot id: L0H222
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS00700
gene id: 765912:THIMO_RS00700
uniprot id: L0GUJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrE/TusD family.
messages: Cytoplasm

765912:THIMO RS12600
gene id: 765912:THIMO_RS12600
uniprot id: L0GZG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

765912:THIMO RS15860
gene id: 765912:THIMO_RS15860
uniprot id: L0GZ33
names: Similarity
messages: Belongs to the MlaA family.

765912:THIMO RS06220
gene id: 765912:THIMO_RS06220
uniprot id: L0GVU5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

765912:THIMO RS01445
gene id: 765912:THIMO_RS01445
uniprot id: L0GUX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

765912:THIMO RS15320
gene id: 765912:THIMO_RS15320
uniprot id: L0H112
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

765912:THIMO RS15510
gene id: 765912:THIMO_RS15510
uniprot id: L0H1L2
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

765912:THIMO RS07360
gene id: 765912:THIMO_RS07360
uniprot id: L0GYD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

765912:THIMO RS13655
gene id: 765912:THIMO_RS13655
uniprot id: L0H1V9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

765912:THIMO RS17320
gene id: 765912:THIMO_RS17320
uniprot id: L0H2L7
names: Function
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).

765912:THIMO RS11205
gene id: 765912:THIMO_RS11205
uniprot id: L0H0H1
names: Similarity
messages: Belongs to the thioredoxin family.

765912:THIMO RS09645
gene id: 765912:THIMO_RS09645
uniprot id: L0GXR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

765912:THIMO RS06305
gene id: 765912:THIMO_RS06305
uniprot id: L0GWA8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS15515
gene id: 765912:THIMO_RS15515
uniprot id: L0H2W9
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

765912:THIMO RS04945
gene id: 765912:THIMO_RS04945
uniprot id: L0GV27
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

765912:THIMO RS04835
gene id: 765912:THIMO_RS04835
uniprot id: L0GWT9
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

765912:THIMO RS09185
gene id: 765912:THIMO_RS09185
uniprot id: L0GXG5
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

765912:THIMO RS08280
gene id: 765912:THIMO_RS08280
uniprot id: L0GYY3
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

765912:THIMO RS05170
gene id: 765912:THIMO_RS05170
uniprot id: L0GWZ1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

765912:THIMO RS12155
gene id: 765912:THIMO_RS12155
uniprot id: L0GWX2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS02805
gene id: 765912:THIMO_RS02805
uniprot id: L0GVV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

765912:THIMO RS14470
gene id: 765912:THIMO_RS14470
uniprot id: L0H0H9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

765912:THIMO RS10010
gene id: 765912:THIMO_RS10010
uniprot id: L0GVP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

765912:THIMO RS16400
gene id: 765912:THIMO_RS16400
uniprot id: L0H245
names: Similarity
messages: Belongs to the MbcT/ParT/Res family.

765912:THIMO RS05015
gene id: 765912:THIMO_RS05015
uniprot id: L0GWW4
names: Similarity
messages: Belongs to the LOG family.

765912:THIMO RS11305
gene id: 765912:THIMO_RS11305
uniprot id: L0GYR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

765912:THIMO RS12695
gene id: 765912:THIMO_RS12695
uniprot id: L0H168
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

765912:THIMO RS12230
gene id: 765912:THIMO_RS12230
uniprot id: L0GWY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

765912:THIMO RS10210
gene id: 765912:THIMO_RS10210
uniprot id: L0GVT6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

765912:THIMO RS02655
gene id: 765912:THIMO_RS02655
uniprot id: L0GTT7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

765912:THIMO RS05055
gene id: 765912:THIMO_RS05055
uniprot id: L0GVK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

765912:THIMO RS15380
gene id: 765912:THIMO_RS15380
uniprot id: L0H1I2
names: Function
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: This protein is a Fe-Mo-cofactor biosynthetic component.

765912:THIMO RS05095
gene id: 765912:THIMO_RS05095
uniprot id: L0GWX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

765912:THIMO RS06345
gene id: 765912:THIMO_RS06345
uniprot id: L0GXL7
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

765912:THIMO RS00935
gene id: 765912:THIMO_RS00935
uniprot id: L0GSV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
messages: The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE).

765912:THIMO RS04515
gene id: 765912:THIMO_RS04515
uniprot id: L0GUV1
names: Similarity
messages: Belongs to the HupJ family.

765912:THIMO RS14270
gene id: 765912:THIMO_RS14270
uniprot id: L0H0E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers.
messages: Belongs to the antenna complex beta subunit family.
messages: Cell inner membrane
messages: Membrane

765912:THIMO RS14505
gene id: 765912:THIMO_RS14505
uniprot id: L0GY94
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

765912:THIMO RS08940
gene id: 765912:THIMO_RS08940
uniprot id: L0GZ25
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

765912:THIMO RS05380
gene id: 765912:THIMO_RS05380
uniprot id: L0GX96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase U32 family. UbiU subfamily.
messages: Forms an heterodimer with UbiV.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiV, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway.

765912:THIMO RS01435
gene id: 765912:THIMO_RS01435
uniprot id: L0GQZ7
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

765912:THIMO RS08540
gene id: 765912:THIMO_RS08540
uniprot id: L0GZ26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

765912:THIMO RS01660
gene id: 765912:THIMO_RS01660
uniprot id: L0GTS3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

765912:THIMO RS17325
gene id: 765912:THIMO_RS17325
uniprot id: L0GZW1
names: Function
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).

765912:THIMO RS01175
gene id: 765912:THIMO_RS01175
uniprot id: L0GSZ1
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

765912:THIMO RS13670
gene id: 765912:THIMO_RS13670
uniprot id: L0H0J1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

765912:THIMO RS06365
gene id: 765912:THIMO_RS06365
uniprot id: L0GXU7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

765912:THIMO RS14755
gene id: 765912:THIMO_RS14755
uniprot id: L0H2B2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

765912:THIMO RS08275
gene id: 765912:THIMO_RS08275
uniprot id: L0GUU0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Homodimer.

765912:THIMO RS15870
gene id: 765912:THIMO_RS15870
uniprot id: L0H2Z0
names: Similarity
messages: Belongs to the glutaredoxin family. Monothiol subfamily.

765912:THIMO RS08150
gene id: 765912:THIMO_RS08150
uniprot id: L0GYP7
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.

765912:THIMO RS04580
gene id: 765912:THIMO_RS04580
uniprot id: L0GUW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

765912:THIMO RS02780
gene id: 765912:THIMO_RS02780
uniprot id: L0GVN4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

765912:THIMO RS03415
gene id: 765912:THIMO_RS03415
uniprot id: L0GUQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RlmKL family.
messages: Cytoplasm
messages: Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.

765912:THIMO RS08000
gene id: 765912:THIMO_RS08000
uniprot id: L0GYJ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

765912:THIMO RS16860
gene id: 765912:THIMO_RS16860
uniprot id: L0H1U1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS14760
gene id: 765912:THIMO_RS14760
uniprot id: L0H0P3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsQ/DivIB family. FtsQ subfamily.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

765912:THIMO RS05280
gene id: 765912:THIMO_RS05280
uniprot id: L0GX13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute-binding proteins (MlaB) and six periplasmic solute-binding proteins (MlaD).

765912:THIMO RS14015
gene id: 765912:THIMO_RS14015
uniprot id: L0H228
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the RuBisCO large chain family. Type I subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterohexadecamer of 8 large chains and 8 small chains.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.
messages: The basic functional RuBisCO is composed of a large chain homodimer in a 'head-to-tail' conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric 'cap' on each end of the 'barrel'.

765912:THIMO RS09655
gene id: 765912:THIMO_RS09655
uniprot id: L0GVI5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M20A family. DapE subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
messages: Homodimer.

765912:THIMO RS16750
gene id: 765912:THIMO_RS16750
uniprot id: L0GZK3
names: Similarity
messages: Belongs to the YkuD family.

765912:THIMO RS05655
gene id: 765912:THIMO_RS05655
uniprot id: L0GVZ0
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

765912:THIMO RS15925
gene id: 765912:THIMO_RS15925
uniprot id: L0H1D8
names: Similarity
messages: Belongs to the HupH/HyaF family.

765912:THIMO RS07875
gene id: 765912:THIMO_RS07875
uniprot id: L0GX72
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

765912:THIMO RS06110
gene id: 765912:THIMO_RS06110
uniprot id: L0GXH5
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

765912:THIMO RS15580
gene id: 765912:THIMO_RS15580
uniprot id: L0H1M6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.

765912:THIMO RS14530
gene id: 765912:THIMO_RS14530
uniprot id: L0H103
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

765912:THIMO RS06480
gene id: 765912:THIMO_RS06480
uniprot id: L0GWE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
messages: Cell inner membrane
messages: Membrane

765912:THIMO RS01595
gene id: 765912:THIMO_RS01595
uniprot id: L0GV07
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

765912:THIMO RS12690
gene id: 765912:THIMO_RS12690
uniprot id: L0H1A7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

765912:THIMO RS11720
gene id: 765912:THIMO_RS11720
uniprot id: L0H0S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

765912:THIMO RS09950
gene id: 765912:THIMO_RS09950
uniprot id: L0GXY2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

765912:THIMO RS00420
gene id: 765912:THIMO_RS00420
uniprot id: L0GUI7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

765912:THIMO RS07995
gene id: 765912:THIMO_RS07995
uniprot id: L0GYR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

765912:THIMO RS03310
gene id: 765912:THIMO_RS03310
uniprot id: L0GU85
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS13580
gene id: 765912:THIMO_RS13580
uniprot id: L0H1U8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

765912:THIMO RS10045
gene id: 765912:THIMO_RS10045
uniprot id: L0GZP7
names: Similarity
messages: Belongs to the KAE1 / TsaD family. TsaB subfamily.

765912:THIMO RS02135
gene id: 765912:THIMO_RS02135
uniprot id: L0GVI0
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

765912:THIMO RS09920
gene id: 765912:THIMO_RS09920
uniprot id: L0GZL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
messages: Cytoplasm
messages: Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.

765912:THIMO RS15545
gene id: 765912:THIMO_RS15545
uniprot id: L0H2R3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptD family.
messages: Cell outer membrane
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptE and LptA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.

765912:THIMO RS14220
gene id: 765912:THIMO_RS14220
uniprot id: L0H0D1
names: Function
messages: Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers.

765912:THIMO RS07035
gene id: 765912:THIMO_RS07035
uniprot id: L0GY05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell inner membrane
messages: Membrane

765912:THIMO RS09790
gene id: 765912:THIMO_RS09790
uniprot id: L0GXU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response.
messages: Belongs to the SrkA/RdoA protein kinase family.
messages: Cytoplasm
messages: Monomer.

765912:THIMO RS06005
gene id: 765912:THIMO_RS06005
uniprot id: L0GTH7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

765912:THIMO RS09805
gene id: 765912:THIMO_RS09805
uniprot id: L0GVL0
names: Function
names: Similarity
messages: Belongs to the bacterioferritin family.
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

765912:THIMO RS09015
gene id: 765912:THIMO_RS09015
uniprot id: L0GXD6
names: Similarity
messages: Belongs to the nitroreductase family. HadB/RutE subfamily.

765912:THIMO RS13085
gene id: 765912:THIMO_RS13085
uniprot id: L0H1J2
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

765912:THIMO RS17195
gene id: 765912:THIMO_RS17195
uniprot id: L0H2J5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.

765912:THIMO RS00260
gene id: 765912:THIMO_RS00260
uniprot id: L0GUE7
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

765912:THIMO RS05625
gene id: 765912:THIMO_RS05625
uniprot id: L0GVJ3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS11715
gene id: 765912:THIMO_RS11715
uniprot id: L0GWP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-transferase family. Bpt subfamily.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.

765912:THIMO RS05285
gene id: 765912:THIMO_RS05285
uniprot id: L0GVA0
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

765912:THIMO RS16050
gene id: 765912:THIMO_RS16050
uniprot id: L0H1X8
names: Subcellular Location Annotation
messages: Nucleus

765912:THIMO RS00195
gene id: 765912:THIMO_RS00195
uniprot id: L0GSF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATPase component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Acts as a molecular motor to provide the energy that is required for assembly of the pseudopilus and the extrusion of substrates generated in the cytoplasm.
messages: Belongs to the GSP E family.
messages: Cell inner membrane

765912:THIMO RS08080
gene id: 765912:THIMO_RS08080
uniprot id: L0GWY8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS11390
gene id: 765912:THIMO_RS11390
uniprot id: L0GWI6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

765912:THIMO RS16660
gene id: 765912:THIMO_RS16660
uniprot id: L0H3C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

765912:THIMO RS09970
gene id: 765912:THIMO_RS09970
uniprot id: L0GZN1
names: Similarity
messages: Belongs to the thioredoxin family.

765912:THIMO RS01610
gene id: 765912:THIMO_RS01610
uniprot id: L0GR29
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS11355
gene id: 765912:THIMO_RS11355
uniprot id: L0GYS3
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

765912:THIMO RS00355
gene id: 765912:THIMO_RS00355
uniprot id: L0GSI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

765912:THIMO RS14875
gene id: 765912:THIMO_RS14875
uniprot id: L0H2J7
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

765912:THIMO RS14790
gene id: 765912:THIMO_RS14790
uniprot id: L0H161
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

765912:THIMO RS04185
gene id: 765912:THIMO_RS04185
uniprot id: L0GSH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MenH family.
messages: Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).
messages: Monomer.

765912:THIMO RS04500
gene id: 765912:THIMO_RS04500
uniprot id: L0GSM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein PotD/PotF family.
messages: Periplasm
messages: Required for the activity of the bacterial periplasmic transport system of putrescine.

765912:THIMO RS09035
gene id: 765912:THIMO_RS09035
uniprot id: L0GZ48
names: Similarity
messages: Belongs to the YfgM family.

765912:THIMO RS08520
gene id: 765912:THIMO_RS08520
uniprot id: L0GYV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

765912:THIMO RS06025
gene id: 765912:THIMO_RS06025
uniprot id: L0GTI1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

765912:THIMO RS02960
gene id: 765912:THIMO_RS02960
uniprot id: L0GRT3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS01920
gene id: 765912:THIMO_RS01920
uniprot id: L0GR86
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

765912:THIMO RS09570
gene id: 765912:THIMO_RS09570
uniprot id: L0GY60
names: Function
names: Similarity
names: Subunit
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.
messages: Interacts with MinC and FtsZ.

765912:THIMO RS03130
gene id: 765912:THIMO_RS03130
uniprot id: L0GUK8
names: Similarity
messages: Belongs to the bacterial secretin family.

765912:THIMO RS12455
gene id: 765912:THIMO_RS12455
uniprot id: L0GX32
names: Similarity
messages: Belongs to the peptidase U62 family.

765912:THIMO RS17160
gene id: 765912:THIMO_RS17160
uniprot id: U3GK59
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

765912:THIMO RS01220
gene id: 765912:THIMO_RS01220
uniprot id: L0GUT1
names: Similarity
messages: Belongs to the HdrA family.

765912:THIMO RS17145
gene id: 765912:THIMO_RS17145
uniprot id: L0H2I6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

765912:THIMO RS15370
gene id: 765912:THIMO_RS15370
uniprot id: L0H2M7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifW family.
messages: Homotrimer; associates with NifD.
messages: May protect the nitrogenase Fe-Mo protein from oxidative damage.

765912:THIMO RS06270
gene id: 765912:THIMO_RS06270
uniprot id: L0GXK2
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS10035
gene id: 765912:THIMO_RS10035
uniprot id: L0GVQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HflD family.
messages: Cell membrane
messages: Cytoplasm

765912:THIMO RS12135
gene id: 765912:THIMO_RS12135
uniprot id: L0H100
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

765912:THIMO RS06860
gene id: 765912:THIMO_RS06860
uniprot id: L0GWL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

765912:THIMO RS13590
gene id: 765912:THIMO_RS13590
uniprot id: L0H019
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

765912:THIMO RS09410
gene id: 765912:THIMO_RS09410
uniprot id: L0GXL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

765912:THIMO RS17305
gene id: 765912:THIMO_RS17305
uniprot id: L0H3Y0
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

765912:THIMO RS07745
gene id: 765912:THIMO_RS07745
uniprot id: L0GYD9
names: Similarity
messages: Belongs to the peptidase S24 family.

765912:THIMO RS02320
gene id: 765912:THIMO_RS02320
uniprot id: L0GU54
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS02935
gene id: 765912:THIMO_RS02935
uniprot id: L0GRQ9
names: Similarity
messages: Belongs to the ModE family.

765912:THIMO RS16840
gene id: 765912:THIMO_RS16840
uniprot id: L0H2C8
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS03045
gene id: 765912:THIMO_RS03045
uniprot id: L0GU38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

765912:THIMO RS02005
gene id: 765912:THIMO_RS02005
uniprot id: L0GV90
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.
messages: Methylates ribosomal protein uL3 on a specific glutamine residue.

765912:THIMO RS14050
gene id: 765912:THIMO_RS14050
uniprot id: L0H091
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

765912:THIMO RS03605
gene id: 765912:THIMO_RS03605
uniprot id: L0GW39
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

765912:THIMO RS03540
gene id: 765912:THIMO_RS03540
uniprot id: L0GUS6
names: Similarity
messages: Belongs to the UPF0758 family.

765912:THIMO RS12520
gene id: 765912:THIMO_RS12520
uniprot id: L0H131
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

765912:THIMO RS09065
gene id: 765912:THIMO_RS09065
uniprot id: L0GXE7
names: Similarity
messages: Belongs to the YkuD family.

765912:THIMO RS16095
gene id: 765912:THIMO_RS16095
uniprot id: L0H1G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

765912:THIMO RS13245
gene id: 765912:THIMO_RS13245
uniprot id: L0H1P7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family. MrdA subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall.
messages: Cell inner membrane

765912:THIMO RS05415
gene id: 765912:THIMO_RS05415
uniprot id: L0GVC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

765912:THIMO RS03515
gene id: 765912:THIMO_RS03515
uniprot id: L0GUS1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

765912:THIMO RS05175
gene id: 765912:THIMO_RS05175
uniprot id: L0GV78
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

765912:THIMO RS06475
gene id: 765912:THIMO_RS06475
uniprot id: L0GVY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbE subfamily.
messages: Cell inner membrane

765912:THIMO RS01935
gene id: 765912:THIMO_RS01935
uniprot id: L0GTD6
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS10420
gene id: 765912:THIMO_RS10420
uniprot id: L0GYL9
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

765912:THIMO RS13510
gene id: 765912:THIMO_RS13510
uniprot id: L0H1N4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

765912:THIMO RS01415
gene id: 765912:THIMO_RS01415
uniprot id: L0GV35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

765912:THIMO RS12215
gene id: 765912:THIMO_RS12215
uniprot id: L0H0W0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ApbE family.
messages: Cell inner membrane
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.

765912:THIMO RS14825
gene id: 765912:THIMO_RS14825
uniprot id: L0H2I8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

765912:THIMO RS00465
gene id: 765912:THIMO_RS00465
uniprot id: L0GQG5
names: Similarity
messages: Belongs to the P(II) protein family.

765912:THIMO RS12675
gene id: 765912:THIMO_RS12675
uniprot id: L0GZH4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS13695
gene id: 765912:THIMO_RS13695
uniprot id: L0H0J5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS15560
gene id: 765912:THIMO_RS15560
uniprot id: L0GYU2
names: Similarity
messages: Belongs to the HupF/HypC family.

765912:THIMO RS06080
gene id: 765912:THIMO_RS06080
uniprot id: L0GXP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

765912:THIMO RS07795
gene id: 765912:THIMO_RS07795
uniprot id: L0GYE8
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

765912:THIMO RS05775
gene id: 765912:THIMO_RS05775
uniprot id: L0GVL9
names: Similarity
messages: Belongs to the peptidase C56 family.

765912:THIMO RS12650
gene id: 765912:THIMO_RS12650
uniprot id: L0GZH3
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

765912:THIMO RS13340
gene id: 765912:THIMO_RS13340
uniprot id: L0GXN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

765912:THIMO RS07175
gene id: 765912:THIMO_RS07175
uniprot id: L0GWC2
names: Function
names: Similarity
messages: Belongs to the CowN family.
messages: Is required to sustain N(2)-dependent growth in the presence of low levels of carbon monoxide (CO). Probably acts by protecting the N(2) fixation ability of the nitrogenase complex, which is inactivated in the presence of CO.

765912:THIMO RS09810
gene id: 765912:THIMO_RS09810
uniprot id: L0GZQ4
names: Function
names: Similarity
messages: Belongs to the bacterioferritin family.
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

765912:THIMO RS03450
gene id: 765912:THIMO_RS03450
uniprot id: L0GW87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

765912:THIMO RS17845
gene id: 765912:THIMO_RS17845
uniprot id: L0H406
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS17110
gene id: 765912:THIMO_RS17110
uniprot id: L0H3K9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

765912:THIMO RS16010
gene id: 765912:THIMO_RS16010
uniprot id: L0H376
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

765912:THIMO RS14120
gene id: 765912:THIMO_RS14120
uniprot id: L0H1Y2
names: Similarity
messages: Belongs to the PhoH family.

765912:THIMO RS08910
gene id: 765912:THIMO_RS08910
uniprot id: L0GZ21
names: Subcellular Location Annotation
messages: Nucleus

765912:THIMO RS00350
gene id: 765912:THIMO_RS00350
uniprot id: L0GUA6
names: Similarity
messages: Belongs to the HesB/IscA family.

765912:THIMO RS11410
gene id: 765912:THIMO_RS11410
uniprot id: L0GZ62
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

765912:THIMO RS01015
gene id: 765912:THIMO_RS01015
uniprot id: L0GQS0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

765912:THIMO RS00900
gene id: 765912:THIMO_RS00900
uniprot id: L0GUT3
names: Similarity
messages: Belongs to the transcriptional regulatory Fis family.

765912:THIMO RS15990
gene id: 765912:THIMO_RS15990
uniprot id: L0H310
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS15555
gene id: 765912:THIMO_RS15555
uniprot id: L0H1M2
names: Similarity
messages: Belongs to the HypD family.

765912:THIMO RS14370
gene id: 765912:THIMO_RS14370
uniprot id: L0H0F9
names: Similarity
messages: Belongs to the PucC family.

765912:THIMO RS03740
gene id: 765912:THIMO_RS03740
uniprot id: L0GS91
names: Similarity
messages: Belongs to the myoviridae tail sheath protein family.

765912:THIMO RS03405
gene id: 765912:THIMO_RS03405
uniprot id: L0GW04
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

765912:THIMO RS02845
gene id: 765912:THIMO_RS02845
uniprot id: L0GUF1
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS05135
gene id: 765912:THIMO_RS05135
uniprot id: L0GSY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

765912:THIMO RS01970
gene id: 765912:THIMO_RS01970
uniprot id: L0GR96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

765912:THIMO RS04100
gene id: 765912:THIMO_RS04100
uniprot id: L0GSG0
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

765912:THIMO RS11405
gene id: 765912:THIMO_RS11405
uniprot id: L0GYT1
names: Function
names: Similarity
messages: Belongs to the DUF177 domain family.
messages: Plays a role in synthesis, processing and/or stability of 23S rRNA.

765912:THIMO RS13205
gene id: 765912:THIMO_RS13205
uniprot id: L0GZV7
names: Similarity
messages: Belongs to the Mg-chelatase subunit H family.

765912:THIMO RS06075
gene id: 765912:THIMO_RS06075
uniprot id: L0GTJ2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

765912:THIMO RS16645
gene id: 765912:THIMO_RS16645
uniprot id: L0H291
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

765912:THIMO RS00800
gene id: 765912:THIMO_RS00800
uniprot id: L0GUK7
names: Similarity
messages: Belongs to the CbbQ/NirQ/NorQ/GpvN family.

765912:THIMO RS08975
gene id: 765912:THIMO_RS08975
uniprot id: L0GXT7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

765912:THIMO RS07825
gene id: 765912:THIMO_RS07825
uniprot id: L0GWR4
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS14905
gene id: 765912:THIMO_RS14905
uniprot id: L0H2K2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

765912:THIMO RS14715
gene id: 765912:THIMO_RS14715
uniprot id: L0H146
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

765912:THIMO RS15220
gene id: 765912:THIMO_RS15220
uniprot id: L0GYM8
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS20645
gene id: 765912:THIMO_RS20645
uniprot id: L0GYX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DksA family.
messages: Cytoplasm
messages: Interacts directly with the RNA polymerase.
messages: Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression.

765912:THIMO RS01390
gene id: 765912:THIMO_RS01390
uniprot id: L0GV30
names: Function
names: Similarity
messages: Belongs to the FlgN family.
messages: Required for the efficient initiation of filament assembly.

765912:THIMO RS13840
gene id: 765912:THIMO_RS13840
uniprot id: U3GKH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 51 family.
messages: Cell inner membrane
messages: Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.

765912:THIMO RS15785
gene id: 765912:THIMO_RS15785
uniprot id: L0H1B5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

765912:THIMO RS11425
gene id: 765912:THIMO_RS11425
uniprot id: L0H0G3
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

765912:THIMO RS13760
gene id: 765912:THIMO_RS13760
uniprot id: L0H042
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

765912:THIMO RS03120
gene id: 765912:THIMO_RS03120
uniprot id: L0GVW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell inner membrane
messages: Membrane

765912:THIMO RS06045
gene id: 765912:THIMO_RS06045
uniprot id: L0GW58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Cell inner membrane
messages: Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA.
messages: Membrane

765912:THIMO RS07225
gene id: 765912:THIMO_RS07225
uniprot id: L0GY37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

765912:THIMO RS18100
gene id: 765912:THIMO_RS18100
uniprot id: L0GUI8
names: Similarity
messages: Belongs to the YkuD family.

765912:THIMO RS14770
gene id: 765912:THIMO_RS14770
uniprot id: L0GYE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

765912:THIMO RS01720
gene id: 765912:THIMO_RS01720
uniprot id: L0GV31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

765912:THIMO RS07445
gene id: 765912:THIMO_RS07445
uniprot id: L0GWY4
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

765912:THIMO RS12610
gene id: 765912:THIMO_RS12610
uniprot id: L0GX65
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

765912:THIMO RS18355
gene id: 765912:THIMO_RS18355
uniprot id: L0GWB0
names: Similarity
messages: Belongs to the N-Me-Phe pilin family.

765912:THIMO RS13295
gene id: 765912:THIMO_RS13295
uniprot id: L0H1K2
names: Similarity
messages: Belongs to the D-alanine--D-alanine ligase family.

765912:THIMO RS00320
gene id: 765912:THIMO_RS00320
uniprot id: L0GUF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Membrane

765912:THIMO RS16655
gene id: 765912:THIMO_RS16655
uniprot id: L0H3J5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

765912:THIMO RS12775
gene id: 765912:THIMO_RS12775
uniprot id: L0H179
names: Similarity
messages: Belongs to the PrpD family.

765912:THIMO RS03460
gene id: 765912:THIMO_RS03460
uniprot id: L0GUA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

765912:THIMO RS14460
gene id: 765912:THIMO_RS14460
uniprot id: L0H2B1
names: Similarity
messages: Belongs to the AlaDH/PNT family.

765912:THIMO RS11985
gene id: 765912:THIMO_RS11985
uniprot id: L0H0R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

765912:THIMO RS00490
gene id: 765912:THIMO_RS00490
uniprot id: L0GQH0
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

765912:THIMO RS13880
gene id: 765912:THIMO_RS13880
uniprot id: L0H0M4
names: Similarity
messages: Belongs to the UPF0502 family.

765912:THIMO RS14465
gene id: 765912:THIMO_RS14465
uniprot id: L0H252
names: Similarity
messages: Belongs to the RNase T2 family.

765912:THIMO RS11960
gene id: 765912:THIMO_RS11960
uniprot id: L0GZH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

765912:THIMO RS02750
gene id: 765912:THIMO_RS02750
uniprot id: L0GVN0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS11335
gene id: 765912:THIMO_RS11335
uniprot id: L0GZ47
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS15325
gene id: 765912:THIMO_RS15325
uniprot id: L0H1G9
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

765912:THIMO RS03665
gene id: 765912:THIMO_RS03665
uniprot id: L0GUV2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

765912:THIMO RS03410
gene id: 765912:THIMO_RS03410
uniprot id: L0GUA0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

765912:THIMO RS11615
gene id: 765912:THIMO_RS11615
uniprot id: L0GWM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm

765912:THIMO RS14735
gene id: 765912:THIMO_RS14735
uniprot id: L0H0N8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RdgC family.
messages: May be involved in recombination.
messages: nucleoid

765912:THIMO RS01600
gene id: 765912:THIMO_RS01600
uniprot id: L0GT66
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxH family.
messages: Binds 2 Mn(2+) ions per subunit in a binuclear metal center.
messages: Cell inner membrane
messages: Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

765912:THIMO RS11250
gene id: 765912:THIMO_RS11250
uniprot id: L0GWG5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
messages: Cell membrane
messages: Heterodimer of a large and a small subunit.

765912:THIMO RS06145
gene id: 765912:THIMO_RS06145
uniprot id: L0GVT4
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

765912:THIMO RS16525
gene id: 765912:THIMO_RS16525
uniprot id: L0GZF2
names: Similarity
messages: Belongs to the MbcT/ParT/Res family.

765912:THIMO RS05720
gene id: 765912:THIMO_RS05720
uniprot id: L0GXB3
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

765912:THIMO RS08610
gene id: 765912:THIMO_RS08610
uniprot id: L0GV01
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

765912:THIMO RS03295
gene id: 765912:THIMO_RS03295
uniprot id: L0GS12
names: Similarity
messages: Belongs to the GSP E family.

765912:THIMO RS17835
gene id: 765912:THIMO_RS17835
uniprot id: L0H065
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS14965
gene id: 765912:THIMO_RS14965
uniprot id: L0H0T7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. UvrD subfamily.
messages: Homodimer.
messages: Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.

765912:THIMO RS16725
gene id: 765912:THIMO_RS16725
uniprot id: L0GZJ9
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS04045
gene id: 765912:THIMO_RS04045
uniprot id: L0GWC9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

765912:THIMO RS13765
gene id: 765912:THIMO_RS13765
uniprot id: L0H0K2
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

765912:THIMO RS05000
gene id: 765912:THIMO_RS05000
uniprot id: L0GVJ2
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.

765912:THIMO RS05750
gene id: 765912:THIMO_RS05750
uniprot id: L0GVL4
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

765912:THIMO RS02940
gene id: 765912:THIMO_RS02940
uniprot id: L0GVX3
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

765912:THIMO RS01655
gene id: 765912:THIMO_RS01655
uniprot id: L0GT74
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS07290
gene id: 765912:THIMO_RS07290
uniprot id: L0GY53
names: Similarity
messages: Belongs to the EcnA/EcnB lipoprotein family.

765912:THIMO RS14245
gene id: 765912:THIMO_RS14245
uniprot id: L0H0D5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers.
messages: Belongs to the antenna complex beta subunit family.
messages: Cell inner membrane
messages: Membrane

765912:THIMO RS10445
gene id: 765912:THIMO_RS10445
uniprot id: L0GYM4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

765912:THIMO RS15890
gene id: 765912:THIMO_RS15890
uniprot id: L0H353
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

765912:THIMO RS06355
gene id: 765912:THIMO_RS06355
uniprot id: L0GWB8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

765912:THIMO RS10785
gene id: 765912:THIMO_RS10785
uniprot id: L0GYI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

765912:THIMO RS12490
gene id: 765912:THIMO_RS12490
uniprot id: L0H126
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS15385
gene id: 765912:THIMO_RS15385
uniprot id: L0GYQ8
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

765912:THIMO RS15770
gene id: 765912:THIMO_RS15770
uniprot id: L0GZ13
names: Similarity
messages: Belongs to the isochorismate synthase family.

765912:THIMO RS01240
gene id: 765912:THIMO_RS01240
uniprot id: L0GUZ8
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

765912:THIMO RS15170
gene id: 765912:THIMO_RS15170
uniprot id: L0GYM0
names: Similarity
messages: Belongs to the UPF0145 family.

765912:THIMO RS13530
gene id: 765912:THIMO_RS13530
uniprot id: L0H1U0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

765912:THIMO RS04070
gene id: 765912:THIMO_RS04070
uniprot id: L0GUK6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

765912:THIMO RS02365
gene id: 765912:THIMO_RS02365
uniprot id: L0GTN3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

765912:THIMO RS13965
gene id: 765912:THIMO_RS13965
uniprot id: L0GXZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

765912:THIMO RS10020
gene id: 765912:THIMO_RS10020
uniprot id: L0GZP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

765912:THIMO RS08510
gene id: 765912:THIMO_RS08510
uniprot id: L0GUY1
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Converts GTP to 7,8-dihydroneopterin triphosphate.

765912:THIMO RS11365
gene id: 765912:THIMO_RS11365
uniprot id: L0GWI3
names: Subunit
messages: Homodimer.

765912:THIMO RS12160
gene id: 765912:THIMO_RS12160
uniprot id: L0H106
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

765912:THIMO RS16320
gene id: 765912:THIMO_RS16320
uniprot id: L0H1K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

765912:THIMO RS04065
gene id: 765912:THIMO_RS04065
uniprot id: L0GWD5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

765912:THIMO RS08755
gene id: 765912:THIMO_RS08755
uniprot id: L0GZ63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

765912:THIMO RS09025
gene id: 765912:THIMO_RS09025
uniprot id: L0GV74
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

765912:THIMO RS03625
gene id: 765912:THIMO_RS03625
uniprot id: L0GWC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

765912:THIMO RS16890
gene id: 765912:THIMO_RS16890
uniprot id: L0H2D7
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

765912:THIMO RS02840
gene id: 765912:THIMO_RS02840
uniprot id: L0GTX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

765912:THIMO RS15600
gene id: 765912:THIMO_RS15600
uniprot id: L0H169
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

765912:THIMO RS01165
gene id: 765912:THIMO_RS01165
uniprot id: L0GUY3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

765912:THIMO RS01945
gene id: 765912:THIMO_RS01945
uniprot id: L0GR91
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS05165
gene id: 765912:THIMO_RS05165
uniprot id: L0GX56
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

765912:THIMO RS10635
gene id: 765912:THIMO_RS10635
uniprot id: L0GYS4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.

765912:THIMO RS11810
gene id: 765912:THIMO_RS11810
uniprot id: L0GZ02
names: Subcellular Location Annotation
messages: Membrane

765912:THIMO RS02740
gene id: 765912:THIMO_RS02740
uniprot id: L0GRN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Pal lipoprotein family.
messages: Cell outer membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

765912:THIMO RS00245
gene id: 765912:THIMO_RS00245
uniprot id: L0GSG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family. GSP D subfamily.
messages: Cell outer membrane
messages: Membrane

765912:THIMO RS13060
gene id: 765912:THIMO_RS13060
uniprot id: L0H1I6
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

765912:THIMO RS15425
gene id: 765912:THIMO_RS15425
uniprot id: L0H135
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Binds 1 [8Fe-7S] cluster per heterodimer.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

765912:THIMO RS14480
gene id: 765912:THIMO_RS14480
uniprot id: L0GY89
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

765912:THIMO RS14240
gene id: 765912:THIMO_RS14240
uniprot id: L0H206
names: Function
messages: Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers.

765912:THIMO RS12005
gene id: 765912:THIMO_RS12005
uniprot id: L0H0X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

765912:THIMO RS17595
gene id: 765912:THIMO_RS17595
uniprot id: L0H013
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

765912:THIMO RS03480
gene id: 765912:THIMO_RS03480
uniprot id: L0GW18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane