762948:HMPREF0733 RS07440
gene id: 762948:HMPREF0733_RS07440
uniprot id: E3H0D3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

762948:HMPREF0733 RS05770
gene id: 762948:HMPREF0733_RS05770
uniprot id: E3H4Q0
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS00240
gene id: 762948:HMPREF0733_RS00240
uniprot id: E3H4F9
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS07405
gene id: 762948:HMPREF0733_RS07405
uniprot id: E3H0C5
names: Similarity
messages: Belongs to the peptidase M16 family.

762948:HMPREF0733 RS05615
gene id: 762948:HMPREF0733_RS05615
uniprot id: E3H4L7
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS01160
gene id: 762948:HMPREF0733_RS01160
uniprot id: E3H5L4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

762948:HMPREF0733 RS00350
gene id: 762948:HMPREF0733_RS00350
uniprot id: E3H4I2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS09515
gene id: 762948:HMPREF0733_RS09515
uniprot id: E3H2U2
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

762948:HMPREF0733 RS10080
gene id: 762948:HMPREF0733_RS10080
uniprot id: E3H3C6
names: Similarity
messages: Belongs to the truncated hemoglobin family. Group II subfamily.

762948:HMPREF0733 RS06615
gene id: 762948:HMPREF0733_RS06615
uniprot id: E3H5S1
names: Similarity
messages: Belongs to the FemABX family.

762948:HMPREF0733 RS06545
gene id: 762948:HMPREF0733_RS06545
uniprot id: E3H5Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

762948:HMPREF0733 RS01580
gene id: 762948:HMPREF0733_RS01580
uniprot id: E3GZQ8
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

762948:HMPREF0733 RS07730
gene id: 762948:HMPREF0733_RS07730
uniprot id: E3H0R5
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS07120
gene id: 762948:HMPREF0733_RS07120
uniprot id: E3GZZ1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

762948:HMPREF0733 RS04295
gene id: 762948:HMPREF0733_RS04295
uniprot id: E3H321
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

762948:HMPREF0733 RS04335
gene id: 762948:HMPREF0733_RS04335
uniprot id: E3H330
names: Similarity
messages: Belongs to the thioredoxin family.

762948:HMPREF0733 RS01460
gene id: 762948:HMPREF0733_RS01460
uniprot id: E3GZN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

762948:HMPREF0733 RS06045
gene id: 762948:HMPREF0733_RS06045
uniprot id: E3H533
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

762948:HMPREF0733 RS09215
gene id: 762948:HMPREF0733_RS09215
uniprot id: E3H2F0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with subunits I, II and III to form cytochrome c oxidase.
messages: Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
messages: Cell membrane
messages: Membrane
messages: Part of cytochrome c oxidase, its function is unknown.

762948:HMPREF0733 RS09795
gene id: 762948:HMPREF0733_RS09795
uniprot id: E3H2Z9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

762948:HMPREF0733 RS05000
gene id: 762948:HMPREF0733_RS05000
uniprot id: E3H3W6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

762948:HMPREF0733 RS06285
gene id: 762948:HMPREF0733_RS06285
uniprot id: E3H5F1
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

762948:HMPREF0733 RS06425
gene id: 762948:HMPREF0733_RS06425
uniprot id: E3H5H9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS10435
gene id: 762948:HMPREF0733_RS10435
uniprot id: E3H3R4
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

762948:HMPREF0733 RS01595
gene id: 762948:HMPREF0733_RS01595
uniprot id: E3GZR2
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS09150
gene id: 762948:HMPREF0733_RS09150
uniprot id: E3H2D8
names: Similarity
messages: Belongs to the peptidase M1 family.

762948:HMPREF0733 RS09275
gene id: 762948:HMPREF0733_RS09275
uniprot id: E3H2G2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

762948:HMPREF0733 RS08795
gene id: 762948:HMPREF0733_RS08795
uniprot id: E3H1Y4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

762948:HMPREF0733 RS01655
gene id: 762948:HMPREF0733_RS01655
uniprot id: E3GZS3
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

762948:HMPREF0733 RS09660
gene id: 762948:HMPREF0733_RS09660
uniprot id: E3H2X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

762948:HMPREF0733 RS06610
gene id: 762948:HMPREF0733_RS06610
uniprot id: E3H5S0
names: Similarity
messages: Belongs to the FBPase class 2 family.

762948:HMPREF0733 RS09345
gene id: 762948:HMPREF0733_RS09345
uniprot id: E3H2H7
names: Similarity
messages: Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily.

762948:HMPREF0733 RS06825
gene id: 762948:HMPREF0733_RS06825
uniprot id: E3H5W3
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

762948:HMPREF0733 RS10560
gene id: 762948:HMPREF0733_RS10560
uniprot id: E3H417
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

762948:HMPREF0733 RS09520
gene id: 762948:HMPREF0733_RS09520
uniprot id: E3H2U3
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS10515
gene id: 762948:HMPREF0733_RS10515
uniprot id: E3H3S9
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS04340
gene id: 762948:HMPREF0733_RS04340
uniprot id: E3H331
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

762948:HMPREF0733 RS03630
gene id: 762948:HMPREF0733_RS03630
uniprot id: E3H278
names: Similarity
messages: Belongs to the nitroreductase family.

762948:HMPREF0733 RS09225
gene id: 762948:HMPREF0733_RS09225
uniprot id: E3H2F2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Cell membrane
messages: Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.

762948:HMPREF0733 RS05135
gene id: 762948:HMPREF0733_RS05135
uniprot id: E3H402
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

762948:HMPREF0733 RS01510
gene id: 762948:HMPREF0733_RS01510
uniprot id: E3GZP4
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS08020
gene id: 762948:HMPREF0733_RS08020
uniprot id: E3H153
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

762948:HMPREF0733 RS08740
gene id: 762948:HMPREF0733_RS08740
uniprot id: E3H1X4
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.

762948:HMPREF0733 RS03550
gene id: 762948:HMPREF0733_RS03550
uniprot id: E3H260
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS07965
gene id: 762948:HMPREF0733_RS07965
uniprot id: E3H0W2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

762948:HMPREF0733 RS06625
gene id: 762948:HMPREF0733_RS06625
uniprot id: E3H5S3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS02610
gene id: 762948:HMPREF0733_RS02610
uniprot id: E3H103
names: Similarity
messages: Belongs to the peptidase C40 family.

762948:HMPREF0733 RS03140
gene id: 762948:HMPREF0733_RS03140
uniprot id: E3H1J3
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS00640
gene id: 762948:HMPREF0733_RS00640
uniprot id: E3H4X2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.
messages: Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
messages: Cytoplasm
messages: Homotrimer.

762948:HMPREF0733 RS07005
gene id: 762948:HMPREF0733_RS07005
uniprot id: E3GZW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

762948:HMPREF0733 RS08675
gene id: 762948:HMPREF0733_RS08675
uniprot id: E3H1P8
names: Function
names: Similarity
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

762948:HMPREF0733 RS09595
gene id: 762948:HMPREF0733_RS09595
uniprot id: E3H2V8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

762948:HMPREF0733 RS10145
gene id: 762948:HMPREF0733_RS10145
uniprot id: E3H3E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A probable RNA-binding protein.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm

762948:HMPREF0733 RS00535
gene id: 762948:HMPREF0733_RS00535
uniprot id: E3H4U8
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

762948:HMPREF0733 RS07610
gene id: 762948:HMPREF0733_RS07610
uniprot id: E3H0G7
names: Similarity
messages: Belongs to the EfeM/EfeO family.

762948:HMPREF0733 RS08340
gene id: 762948:HMPREF0733_RS08340
uniprot id: E3H1C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

762948:HMPREF0733 RS09380
gene id: 762948:HMPREF0733_RS09380
uniprot id: E3H2I4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

762948:HMPREF0733 RS06145
gene id: 762948:HMPREF0733_RS06145
uniprot id: E3H553
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: May be specifically involved in the processing, transport, and/or maturation of the MADH beta-subunit.
messages: Membrane

762948:HMPREF0733 RS08600
gene id: 762948:HMPREF0733_RS08600
uniprot id: E3H1N3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

762948:HMPREF0733 RS09945
gene id: 762948:HMPREF0733_RS09945
uniprot id: E3H397
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Membrane

762948:HMPREF0733 RS08690
gene id: 762948:HMPREF0733_RS08690
uniprot id: E3H1Q1
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

762948:HMPREF0733 RS05800
gene id: 762948:HMPREF0733_RS05800
uniprot id: E3H4Q7
names: Similarity
messages: Belongs to the AHA1 family.

762948:HMPREF0733 RS06575
gene id: 762948:HMPREF0733_RS06575
uniprot id: E3H5R3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS00250
gene id: 762948:HMPREF0733_RS00250
uniprot id: E3H4G1
names: Similarity
messages: Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.

762948:HMPREF0733 RS03390
gene id: 762948:HMPREF0733_RS03390
uniprot id: E3H1V9
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

762948:HMPREF0733 RS01550
gene id: 762948:HMPREF0733_RS01550
uniprot id: E3GZQ2
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

762948:HMPREF0733 RS09165
gene id: 762948:HMPREF0733_RS09165
uniprot id: E3H2E0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS09090
gene id: 762948:HMPREF0733_RS09090
uniprot id: E3H2C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

762948:HMPREF0733 RS06710
gene id: 762948:HMPREF0733_RS06710
uniprot id: E3H5U0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS07705
gene id: 762948:HMPREF0733_RS07705
uniprot id: E3H0R0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS01445
gene id: 762948:HMPREF0733_RS01445
uniprot id: E3GZN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

762948:HMPREF0733 RS07765
gene id: 762948:HMPREF0733_RS07765
uniprot id: E3H0S2
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

762948:HMPREF0733 RS08685
gene id: 762948:HMPREF0733_RS08685
uniprot id: E3H1Q0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

762948:HMPREF0733 RS07180
gene id: 762948:HMPREF0733_RS07180
uniprot id: E3H003
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

762948:HMPREF0733 RS04285
gene id: 762948:HMPREF0733_RS04285
uniprot id: E3H319
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

762948:HMPREF0733 RS10395
gene id: 762948:HMPREF0733_RS10395
uniprot id: E3H3Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

762948:HMPREF0733 RS02540
gene id: 762948:HMPREF0733_RS02540
uniprot id: E3H0Y8
names: Similarity
messages: Belongs to the Dps family.

762948:HMPREF0733 RS04715
gene id: 762948:HMPREF0733_RS04715
uniprot id: E3H3I7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

762948:HMPREF0733 RS08205
gene id: 762948:HMPREF0733_RS08205
uniprot id: E3H191
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

762948:HMPREF0733 RS01105
gene id: 762948:HMPREF0733_RS01105
uniprot id: E3H5E6
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

762948:HMPREF0733 RS05390
gene id: 762948:HMPREF0733_RS05390
uniprot id: E3H499
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

762948:HMPREF0733 RS06480
gene id: 762948:HMPREF0733_RS06480
uniprot id: E3H5J1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

762948:HMPREF0733 RS09525
gene id: 762948:HMPREF0733_RS09525
uniprot id: E3H2U4
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

762948:HMPREF0733 RS04995
gene id: 762948:HMPREF0733_RS04995
uniprot id: E3H3W5
names: Similarity
messages: Belongs to the peptidase M13 family.

762948:HMPREF0733 RS01920
gene id: 762948:HMPREF0733_RS01920
uniprot id: E3H053
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

762948:HMPREF0733 RS01830
gene id: 762948:HMPREF0733_RS01830
uniprot id: E3H037
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

762948:HMPREF0733 RS05190
gene id: 762948:HMPREF0733_RS05190
uniprot id: E3H453
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

762948:HMPREF0733 RS04310
gene id: 762948:HMPREF0733_RS04310
uniprot id: E3H325
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

762948:HMPREF0733 RS09885
gene id: 762948:HMPREF0733_RS09885
uniprot id: E3H385
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

762948:HMPREF0733 RS04200
gene id: 762948:HMPREF0733_RS04200
uniprot id: E3H307
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

762948:HMPREF0733 RS05485
gene id: 762948:HMPREF0733_RS05485
uniprot id: E3H4C1
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

762948:HMPREF0733 RS02565
gene id: 762948:HMPREF0733_RS02565
uniprot id: E3H0Z3
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

762948:HMPREF0733 RS06385
gene id: 762948:HMPREF0733_RS06385
uniprot id: E3H5H1
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

762948:HMPREF0733 RS09335
gene id: 762948:HMPREF0733_RS09335
uniprot id: E3H2H5
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
messages: Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
messages: The reaction mechanism probably proceeds via the activation of Pup by phosphorylation of its C-terminal glutamate, which is then subject to nucleophilic attack by the substrate lysine, resulting in an isopeptide bond and the release of phosphate as a good leaving group.

762948:HMPREF0733 RS01325
gene id: 762948:HMPREF0733_RS01325
uniprot id: E3H5P9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

762948:HMPREF0733 RS01885
gene id: 762948:HMPREF0733_RS01885
uniprot id: E3H045
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

762948:HMPREF0733 RS02045
gene id: 762948:HMPREF0733_RS02045
uniprot id: E3H080
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS01630
gene id: 762948:HMPREF0733_RS01630
uniprot id: E3GZR9
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

762948:HMPREF0733 RS06595
gene id: 762948:HMPREF0733_RS06595
uniprot id: E3H5R7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

762948:HMPREF0733 RS06580
gene id: 762948:HMPREF0733_RS06580
uniprot id: E3H5R4
names: Similarity
messages: Belongs to the peptidase A24 family.

762948:HMPREF0733 RS02225
gene id: 762948:HMPREF0733_RS02225
uniprot id: E3H0J7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS00500
gene id: 762948:HMPREF0733_RS00500
uniprot id: E3H4U0
names: Similarity
messages: Belongs to the UPF0310 family.

762948:HMPREF0733 RS09055
gene id: 762948:HMPREF0733_RS09055
uniprot id: E3H2B8
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

762948:HMPREF0733 RS08630
gene id: 762948:HMPREF0733_RS08630
uniprot id: E3H1N9
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

762948:HMPREF0733 RS08500
gene id: 762948:HMPREF0733_RS08500
uniprot id: E3H1L8
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS10260
gene id: 762948:HMPREF0733_RS10260
uniprot id: E3H3M9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

762948:HMPREF0733 RS07020
gene id: 762948:HMPREF0733_RS07020
uniprot id: E3GZX0
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

762948:HMPREF0733 RS09270
gene id: 762948:HMPREF0733_RS09270
uniprot id: E3H2G1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

762948:HMPREF0733 RS09840
gene id: 762948:HMPREF0733_RS09840
uniprot id: E3H376
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Electron transport system for the ribonucleotide reductase system NrdEF.

762948:HMPREF0733 RS06735
gene id: 762948:HMPREF0733_RS06735
uniprot id: E3H5U5
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS00235
gene id: 762948:HMPREF0733_RS00235
uniprot id: E3H4F8
names: Similarity
messages: Belongs to the ABC transporter superfamily.

762948:HMPREF0733 RS06500
gene id: 762948:HMPREF0733_RS06500
uniprot id: E3H5J6
names: Similarity
messages: Belongs to the peptidase S8 family.

762948:HMPREF0733 RS02955
gene id: 762948:HMPREF0733_RS02955
uniprot id: E3H1F6
names: Function
names: Similarity
messages: Belongs to the BCKDHA family.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

762948:HMPREF0733 RS03490
gene id: 762948:HMPREF0733_RS03490
uniprot id: E3H244
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

762948:HMPREF0733 RS02760
gene id: 762948:HMPREF0733_RS02760
uniprot id: E3H135
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

762948:HMPREF0733 RS04890
gene id: 762948:HMPREF0733_RS04890
uniprot id: E3H3U4
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

762948:HMPREF0733 RS05630
gene id: 762948:HMPREF0733_RS05630
uniprot id: E3H4M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

762948:HMPREF0733 RS08995
gene id: 762948:HMPREF0733_RS08995
uniprot id: E3H229
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

762948:HMPREF0733 RS01350
gene id: 762948:HMPREF0733_RS01350
uniprot id: E3H5Q4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

762948:HMPREF0733 RS05900
gene id: 762948:HMPREF0733_RS05900
uniprot id: E3H507
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

762948:HMPREF0733 RS03695
gene id: 762948:HMPREF0733_RS03695
uniprot id: E3H292
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

762948:HMPREF0733 RS09830
gene id: 762948:HMPREF0733_RS09830
uniprot id: E3H374
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

762948:HMPREF0733 RS07585
gene id: 762948:HMPREF0733_RS07585
uniprot id: E3H0G2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

762948:HMPREF0733 RS09585
gene id: 762948:HMPREF0733_RS09585
uniprot id: E3H2V6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

762948:HMPREF0733 RS05310
gene id: 762948:HMPREF0733_RS05310
uniprot id: E3H481
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

762948:HMPREF0733 RS09785
gene id: 762948:HMPREF0733_RS09785
uniprot id: E3H2Z7
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

762948:HMPREF0733 RS08225
gene id: 762948:HMPREF0733_RS08225
uniprot id: E3H195
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

762948:HMPREF0733 RS03335
gene id: 762948:HMPREF0733_RS03335
uniprot id: E3H1U8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.

762948:HMPREF0733 RS07985
gene id: 762948:HMPREF0733_RS07985
uniprot id: E3H0W6
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

762948:HMPREF0733 RS07960
gene id: 762948:HMPREF0733_RS07960
uniprot id: E3H0W1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS01315
gene id: 762948:HMPREF0733_RS01315
uniprot id: E3H5P7
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

762948:HMPREF0733 RS10540
gene id: 762948:HMPREF0733_RS10540
uniprot id: E3H413
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

762948:HMPREF0733 RS10060
gene id: 762948:HMPREF0733_RS10060
uniprot id: E3H3C1
names: Similarity
messages: Belongs to the FPG family.

762948:HMPREF0733 RS10135
gene id: 762948:HMPREF0733_RS10135
uniprot id: E3H3D8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates guanosine-37 in various tRNAs.

762948:HMPREF0733 RS00190
gene id: 762948:HMPREF0733_RS00190
uniprot id: E3H4E9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

762948:HMPREF0733 RS09940
gene id: 762948:HMPREF0733_RS09940
uniprot id: E3H396
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

762948:HMPREF0733 RS10180
gene id: 762948:HMPREF0733_RS10180
uniprot id: E3H3L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. TCR/Tet family.
messages: Membrane

762948:HMPREF0733 RS10440
gene id: 762948:HMPREF0733_RS10440
uniprot id: E3H3R5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

762948:HMPREF0733 RS07760
gene id: 762948:HMPREF0733_RS07760
uniprot id: E3H0S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

762948:HMPREF0733 RS00730
gene id: 762948:HMPREF0733_RS00730
uniprot id: E3H4Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
messages: Membrane

762948:HMPREF0733 RS09410
gene id: 762948:HMPREF0733_RS09410
uniprot id: E3H2J0
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

762948:HMPREF0733 RS09645
gene id: 762948:HMPREF0733_RS09645
uniprot id: E3H2W9
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

762948:HMPREF0733 RS08670
gene id: 762948:HMPREF0733_RS08670
uniprot id: E3H1P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.
messages: Membrane

762948:HMPREF0733 RS01390
gene id: 762948:HMPREF0733_RS01390
uniprot id: E3GZL8
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

762948:HMPREF0733 RS07955
gene id: 762948:HMPREF0733_RS07955
uniprot id: E3H0W0
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS06420
gene id: 762948:HMPREF0733_RS06420
uniprot id: E3H5H8
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

762948:HMPREF0733 RS00770
gene id: 762948:HMPREF0733_RS00770
uniprot id: E3H500
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

762948:HMPREF0733 RS10150
gene id: 762948:HMPREF0733_RS10150
uniprot id: E3H3E1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

762948:HMPREF0733 RS01270
gene id: 762948:HMPREF0733_RS01270
uniprot id: E3H5N8
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

762948:HMPREF0733 RS01680
gene id: 762948:HMPREF0733_RS01680
uniprot id: E3GZS8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. MshD subfamily.
messages: Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

762948:HMPREF0733 RS08290
gene id: 762948:HMPREF0733_RS08290
uniprot id: E3H1A8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

762948:HMPREF0733 RS08005
gene id: 762948:HMPREF0733_RS08005
uniprot id: E3H0X1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

762948:HMPREF0733 RS09825
gene id: 762948:HMPREF0733_RS09825
uniprot id: E3H373
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
messages: Tetramer of two alpha and two beta subunits.

762948:HMPREF0733 RS02770
gene id: 762948:HMPREF0733_RS02770
uniprot id: E3H137
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

762948:HMPREF0733 RS02740
gene id: 762948:HMPREF0733_RS02740
uniprot id: E3H130
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

762948:HMPREF0733 RS01465
gene id: 762948:HMPREF0733_RS01465
uniprot id: E3GZN5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

762948:HMPREF0733 RS02560
gene id: 762948:HMPREF0733_RS02560
uniprot id: E3H0Z2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

762948:HMPREF0733 RS08195
gene id: 762948:HMPREF0733_RS08195
uniprot id: E3H189
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

762948:HMPREF0733 RS05705
gene id: 762948:HMPREF0733_RS05705
uniprot id: E3H4N7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

762948:HMPREF0733 RS07605
gene id: 762948:HMPREF0733_RS07605
uniprot id: E3H0G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

762948:HMPREF0733 RS09495
gene id: 762948:HMPREF0733_RS09495
uniprot id: E3H2T8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS00195
gene id: 762948:HMPREF0733_RS00195
uniprot id: E3H4F0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

762948:HMPREF0733 RS00310
gene id: 762948:HMPREF0733_RS00310
uniprot id: E3H4H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

762948:HMPREF0733 RS08230
gene id: 762948:HMPREF0733_RS08230
uniprot id: E3H196
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane

762948:HMPREF0733 RS09325
gene id: 762948:HMPREF0733_RS09325
uniprot id: E3H2H3
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

762948:HMPREF0733 RS01410
gene id: 762948:HMPREF0733_RS01410
uniprot id: E3GZM2
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

762948:HMPREF0733 RS00565
gene id: 762948:HMPREF0733_RS00565
uniprot id: E3H4V5
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

762948:HMPREF0733 RS09535
gene id: 762948:HMPREF0733_RS09535
uniprot id: E3H2U6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS05445
gene id: 762948:HMPREF0733_RS05445
uniprot id: E3H4B2
names: Similarity
messages: Belongs to the NtaA/SnaA/DszA monooxygenase family.

762948:HMPREF0733 RS10275
gene id: 762948:HMPREF0733_RS10275
uniprot id: E3H3N2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS03075
gene id: 762948:HMPREF0733_RS03075
uniprot id: E3H1H9
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

762948:HMPREF0733 RS02640
gene id: 762948:HMPREF0733_RS02640
uniprot id: E3H109
names: Similarity
messages: Belongs to the WXG100 family.

762948:HMPREF0733 RS02240
gene id: 762948:HMPREF0733_RS02240
uniprot id: E3H0K0
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS01940
gene id: 762948:HMPREF0733_RS01940
uniprot id: E3H058
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

762948:HMPREF0733 RS01865
gene id: 762948:HMPREF0733_RS01865
uniprot id: E3H042
names: Similarity
messages: Belongs to the thioredoxin family.

762948:HMPREF0733 RS01925
gene id: 762948:HMPREF0733_RS01925
uniprot id: E3H055
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS06120
gene id: 762948:HMPREF0733_RS06120
uniprot id: E3H548
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

762948:HMPREF0733 RS05250
gene id: 762948:HMPREF0733_RS05250
uniprot id: E3H468
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

762948:HMPREF0733 RS01760
gene id: 762948:HMPREF0733_RS01760
uniprot id: E3H023
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

762948:HMPREF0733 RS08030
gene id: 762948:HMPREF0733_RS08030
uniprot id: E3H155
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

762948:HMPREF0733 RS07515
gene id: 762948:HMPREF0733_RS07515
uniprot id: E3H0E8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS05710
gene id: 762948:HMPREF0733_RS05710
uniprot id: E3H4N8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

762948:HMPREF0733 RS08950
gene id: 762948:HMPREF0733_RS08950
uniprot id: E3H220
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

762948:HMPREF0733 RS09405
gene id: 762948:HMPREF0733_RS09405
uniprot id: E3H2I9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

762948:HMPREF0733 RS04280
gene id: 762948:HMPREF0733_RS04280
uniprot id: E3H318
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

762948:HMPREF0733 RS10070
gene id: 762948:HMPREF0733_RS10070
uniprot id: E3H3C4
names: Similarity
messages: Belongs to the peptidase M1 family.

762948:HMPREF0733 RS07885
gene id: 762948:HMPREF0733_RS07885
uniprot id: E3H0U6
names: Cofactor
names: Similarity
messages: Belongs to the class-II DAHP synthase family.
messages: Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.

762948:HMPREF0733 RS02440
gene id: 762948:HMPREF0733_RS02440
uniprot id: E3H0P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

762948:HMPREF0733 RS10345
gene id: 762948:HMPREF0733_RS10345
uniprot id: E3H3P6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

762948:HMPREF0733 RS09540
gene id: 762948:HMPREF0733_RS09540
uniprot id: E3H2U7
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

762948:HMPREF0733 RS01050
gene id: 762948:HMPREF0733_RS01050
uniprot id: E3H5D4
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS06210
gene id: 762948:HMPREF0733_RS06210
uniprot id: E3H565
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS00230
gene id: 762948:HMPREF0733_RS00230
uniprot id: E3H4F7
names: Similarity
messages: Belongs to the GSP E family.

762948:HMPREF0733 RS05715
gene id: 762948:HMPREF0733_RS05715
uniprot id: E3H4N9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

762948:HMPREF0733 RS09105
gene id: 762948:HMPREF0733_RS09105
uniprot id: E3H2C8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS03455
gene id: 762948:HMPREF0733_RS03455
uniprot id: E3H237
names: Similarity
messages: Belongs to the peptidase S13 family.

762948:HMPREF0733 RS10555
gene id: 762948:HMPREF0733_RS10555
uniprot id: E3H416
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

762948:HMPREF0733 RS09315
gene id: 762948:HMPREF0733_RS09315
uniprot id: E3H2H0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

762948:HMPREF0733 RS08150
gene id: 762948:HMPREF0733_RS08150
uniprot id: E3H180
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

762948:HMPREF0733 RS07365
gene id: 762948:HMPREF0733_RS07365
uniprot id: E3H0B7
names: Similarity
messages: Belongs to the ribF family.

762948:HMPREF0733 RS02795
gene id: 762948:HMPREF0733_RS02795
uniprot id: E3H144
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS03355
gene id: 762948:HMPREF0733_RS03355
uniprot id: E3H1V2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

762948:HMPREF0733 RS01285
gene id: 762948:HMPREF0733_RS01285
uniprot id: E3H5P1
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

762948:HMPREF0733 RS06320
gene id: 762948:HMPREF0733_RS06320
uniprot id: E3H5F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
messages: Membrane

762948:HMPREF0733 RS00050
gene id: 762948:HMPREF0733_RS00050
uniprot id: E3H445
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

762948:HMPREF0733 RS04735
gene id: 762948:HMPREF0733_RS04735
uniprot id: E3H3J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

762948:HMPREF0733 RS08695
gene id: 762948:HMPREF0733_RS08695
uniprot id: E3H1Q2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

762948:HMPREF0733 RS07950
gene id: 762948:HMPREF0733_RS07950
uniprot id: E3H0V9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

762948:HMPREF0733 RS10210
gene id: 762948:HMPREF0733_RS10210
uniprot id: E3H3L9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

762948:HMPREF0733 RS04000
gene id: 762948:HMPREF0733_RS04000
uniprot id: E3H2N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

762948:HMPREF0733 RS07345
gene id: 762948:HMPREF0733_RS07345
uniprot id: E3H0B3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

762948:HMPREF0733 RS03580
gene id: 762948:HMPREF0733_RS03580
uniprot id: E3H268
names: Similarity
messages: Belongs to the UPF0045 family.

762948:HMPREF0733 RS08040
gene id: 762948:HMPREF0733_RS08040
uniprot id: E3H157
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

762948:HMPREF0733 RS09650
gene id: 762948:HMPREF0733_RS09650
uniprot id: E3H2X0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

762948:HMPREF0733 RS07390
gene id: 762948:HMPREF0733_RS07390
uniprot id: E3H0C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
messages: Membrane

762948:HMPREF0733 RS10105
gene id: 762948:HMPREF0733_RS10105
uniprot id: E3H3D2
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

762948:HMPREF0733 RS08215
gene id: 762948:HMPREF0733_RS08215
uniprot id: E3H193
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

762948:HMPREF0733 RS06455
gene id: 762948:HMPREF0733_RS06455
uniprot id: E3H5I5
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

762948:HMPREF0733 RS01425
gene id: 762948:HMPREF0733_RS01425
uniprot id: E3GZM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

762948:HMPREF0733 RS09740
gene id: 762948:HMPREF0733_RS09740
uniprot id: E3H2Y8
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS06965
gene id: 762948:HMPREF0733_RS06965
uniprot id: E3GZW0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus membrane

762948:HMPREF0733 RS04430
gene id: 762948:HMPREF0733_RS04430
uniprot id: E3H351
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

762948:HMPREF0733 RS04480
gene id: 762948:HMPREF0733_RS04480
uniprot id: E3H360
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrgA family.
messages: Cell membrane
messages: Involved in cell division.

762948:HMPREF0733 RS02435
gene id: 762948:HMPREF0733_RS02435
uniprot id: E3H0P1
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

762948:HMPREF0733 RS06855
gene id: 762948:HMPREF0733_RS06855
uniprot id: E3H5X1
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

762948:HMPREF0733 RS05465
gene id: 762948:HMPREF0733_RS05465
uniprot id: E3H4B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

762948:HMPREF0733 RS10385
gene id: 762948:HMPREF0733_RS10385
uniprot id: E3H3Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Fes family.
messages: Cytoplasm

762948:HMPREF0733 RS01950
gene id: 762948:HMPREF0733_RS01950
uniprot id: E3H060
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

762948:HMPREF0733 RS09655
gene id: 762948:HMPREF0733_RS09655
uniprot id: E3H2X1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

762948:HMPREF0733 RS06040
gene id: 762948:HMPREF0733_RS06040
uniprot id: E3H532
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

762948:HMPREF0733 RS07455
gene id: 762948:HMPREF0733_RS07455
uniprot id: E3H0D6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

762948:HMPREF0733 RS02445
gene id: 762948:HMPREF0733_RS02445
uniprot id: E3H0P3
names: Similarity
messages: Belongs to the peptidase S8 family.

762948:HMPREF0733 RS08070
gene id: 762948:HMPREF0733_RS08070
uniprot id: E3H163
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

762948:HMPREF0733 RS06035
gene id: 762948:HMPREF0733_RS06035
uniprot id: E3H531
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

762948:HMPREF0733 RS02870
gene id: 762948:HMPREF0733_RS02870
uniprot id: E3H1D7
names: Similarity
messages: Belongs to the thiolase-like superfamily. FabH family.

762948:HMPREF0733 RS00575
gene id: 762948:HMPREF0733_RS00575
uniprot id: E3H4V8
names: Similarity
messages: Belongs to the DEAD box helicase family.

762948:HMPREF0733 RS01480
gene id: 762948:HMPREF0733_RS01480
uniprot id: E3GZN8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

762948:HMPREF0733 RS07225
gene id: 762948:HMPREF0733_RS07225
uniprot id: E3H012
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

762948:HMPREF0733 RS08310
gene id: 762948:HMPREF0733_RS08310
uniprot id: E3H1B2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

762948:HMPREF0733 RS06110
gene id: 762948:HMPREF0733_RS06110
uniprot id: E3H546
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

762948:HMPREF0733 RS07655
gene id: 762948:HMPREF0733_RS07655
uniprot id: E3H0Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

762948:HMPREF0733 RS00460
gene id: 762948:HMPREF0733_RS00460
uniprot id: E3H4T2
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

762948:HMPREF0733 RS08925
gene id: 762948:HMPREF0733_RS08925
uniprot id: E3H214
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

762948:HMPREF0733 RS08180
gene id: 762948:HMPREF0733_RS08180
uniprot id: E3H186
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS05895
gene id: 762948:HMPREF0733_RS05895
uniprot id: E3H506
names: Similarity
messages: Belongs to the phosphohexose mutase family.

762948:HMPREF0733 RS00665
gene id: 762948:HMPREF0733_RS00665
uniprot id: E3H4X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

762948:HMPREF0733 RS00925
gene id: 762948:HMPREF0733_RS00925
uniprot id: E3H5A9
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS06240
gene id: 762948:HMPREF0733_RS06240
uniprot id: E3H572
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS09630
gene id: 762948:HMPREF0733_RS09630
uniprot id: E3H2W6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

762948:HMPREF0733 RS07375
gene id: 762948:HMPREF0733_RS07375
uniprot id: E3H0B9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Binds 1 Fe cation per subunit.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

762948:HMPREF0733 RS04290
gene id: 762948:HMPREF0733_RS04290
uniprot id: E3H320
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

762948:HMPREF0733 RS07600
gene id: 762948:HMPREF0733_RS07600
uniprot id: E3H0G5
names: Similarity
messages: Belongs to the Nudix hydrolase family.

762948:HMPREF0733 RS06840
gene id: 762948:HMPREF0733_RS06840
uniprot id: E3H5W6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

762948:HMPREF0733 RS08130
gene id: 762948:HMPREF0733_RS08130
uniprot id: E3H175
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

762948:HMPREF0733 RS00395
gene id: 762948:HMPREF0733_RS00395
uniprot id: E3H4J3
names: Similarity
messages: Belongs to the PspA/IM30 family.

762948:HMPREF0733 RS01295
gene id: 762948:HMPREF0733_RS01295
uniprot id: E3H5P3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

762948:HMPREF0733 RS09370
gene id: 762948:HMPREF0733_RS09370
uniprot id: E3H2I2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Cytoplasm
messages: Homodimer.

762948:HMPREF0733 RS06255
gene id: 762948:HMPREF0733_RS06255
uniprot id: E3H575
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Membrane

762948:HMPREF0733 RS05605
gene id: 762948:HMPREF0733_RS05605
uniprot id: E3H4L5
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS01450
gene id: 762948:HMPREF0733_RS01450
uniprot id: E3GZN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

762948:HMPREF0733 RS04305
gene id: 762948:HMPREF0733_RS04305
uniprot id: E3H324
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

762948:HMPREF0733 RS09675
gene id: 762948:HMPREF0733_RS09675
uniprot id: E3H2X5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

762948:HMPREF0733 RS02490
gene id: 762948:HMPREF0733_RS02490
uniprot id: E3H0X7
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS03590
gene id: 762948:HMPREF0733_RS03590
uniprot id: E3H270
names: Similarity
messages: Belongs to the HepT RNase toxin family.

762948:HMPREF0733 RS00700
gene id: 762948:HMPREF0733_RS00700
uniprot id: E3H4Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

762948:HMPREF0733 RS08715
gene id: 762948:HMPREF0733_RS08715
uniprot id: E3H1Q6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

762948:HMPREF0733 RS06185
gene id: 762948:HMPREF0733_RS06185
uniprot id: E3H561
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

762948:HMPREF0733 RS00505
gene id: 762948:HMPREF0733_RS00505
uniprot id: E3H4U1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

762948:HMPREF0733 RS05925
gene id: 762948:HMPREF0733_RS05925
uniprot id: E3H512
names: Similarity
names: Subunit
messages: Belongs to the UPF0210 family.
messages: Homodimer.

762948:HMPREF0733 RS10280
gene id: 762948:HMPREF0733_RS10280
uniprot id: E3H3N3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

762948:HMPREF0733 RS03300
gene id: 762948:HMPREF0733_RS03300
uniprot id: E3H1U0
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS08540
gene id: 762948:HMPREF0733_RS08540
uniprot id: E3H1M2
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

762948:HMPREF0733 RS10090
gene id: 762948:HMPREF0733_RS10090
uniprot id: E3H3C8
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

762948:HMPREF0733 RS01240
gene id: 762948:HMPREF0733_RS01240
uniprot id: E3H5N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic pantothenate kinase family.
messages: Cytoplasm

762948:HMPREF0733 RS05115
gene id: 762948:HMPREF0733_RS05115
uniprot id: E3H3Z8
names: Similarity
messages: Belongs to the ABC transporter superfamily.

762948:HMPREF0733 RS11515
gene id: 762948:HMPREF0733_RS11515
uniprot id: E3H4P2
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

762948:HMPREF0733 RS08155
gene id: 762948:HMPREF0733_RS08155
uniprot id: E3H181
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

762948:HMPREF0733 RS01420
gene id: 762948:HMPREF0733_RS01420
uniprot id: E3GZM4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

762948:HMPREF0733 RS10425
gene id: 762948:HMPREF0733_RS10425
uniprot id: E3H3R2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

762948:HMPREF0733 RS04590
gene id: 762948:HMPREF0733_RS04590
uniprot id: E3H3G0
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS02550
gene id: 762948:HMPREF0733_RS02550
uniprot id: E3H0Z0
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS01320
gene id: 762948:HMPREF0733_RS01320
uniprot id: E3H5P8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

762948:HMPREF0733 RS00610
gene id: 762948:HMPREF0733_RS00610
uniprot id: E3H4W5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

762948:HMPREF0733 RS07300
gene id: 762948:HMPREF0733_RS07300
uniprot id: E3H0A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

762948:HMPREF0733 RS06850
gene id: 762948:HMPREF0733_RS06850
uniprot id: E3H5X0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

762948:HMPREF0733 RS11430
gene id: 762948:HMPREF0733_RS11430
uniprot id: E3H5S6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

762948:HMPREF0733 RS07625
gene id: 762948:HMPREF0733_RS07625
uniprot id: E3H0H0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

762948:HMPREF0733 RS00060
gene id: 762948:HMPREF0733_RS00060
uniprot id: E3H447
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS07935
gene id: 762948:HMPREF0733_RS07935
uniprot id: E3H0V6
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS05260
gene id: 762948:HMPREF0733_RS05260
uniprot id: E3H471
names: Similarity
messages: Belongs to the peptidase S8 family.

762948:HMPREF0733 RS05265
gene id: 762948:HMPREF0733_RS05265
uniprot id: E3H472
names: Similarity
messages: Belongs to the peptidase S8 family.

762948:HMPREF0733 RS04195
gene id: 762948:HMPREF0733_RS04195
uniprot id: E3H306
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS08460
gene id: 762948:HMPREF0733_RS08460
uniprot id: E3H1L0
names: Function
messages: Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.

762948:HMPREF0733 RS01370
gene id: 762948:HMPREF0733_RS01370
uniprot id: E3GZL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

762948:HMPREF0733 RS00375
gene id: 762948:HMPREF0733_RS00375
uniprot id: E3H4I7
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

762948:HMPREF0733 RS09210
gene id: 762948:HMPREF0733_RS09210
uniprot id: E3H2E9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

762948:HMPREF0733 RS08085
gene id: 762948:HMPREF0733_RS08085
uniprot id: E3H166
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

762948:HMPREF0733 RS01290
gene id: 762948:HMPREF0733_RS01290
uniprot id: E3H5P2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

762948:HMPREF0733 RS09160
gene id: 762948:HMPREF0733_RS09160
uniprot id: E3H2D9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

762948:HMPREF0733 RS07940
gene id: 762948:HMPREF0733_RS07940
uniprot id: E3H0V7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

762948:HMPREF0733 RS08090
gene id: 762948:HMPREF0733_RS08090
uniprot id: E3H167
names: Similarity
messages: Belongs to the YoeB family.

762948:HMPREF0733 RS01355
gene id: 762948:HMPREF0733_RS01355
uniprot id: E3H5Q5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

762948:HMPREF0733 RS03160
gene id: 762948:HMPREF0733_RS03160
uniprot id: E3H1R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

762948:HMPREF0733 RS01620
gene id: 762948:HMPREF0733_RS01620
uniprot id: E3GZR7
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS03670
gene id: 762948:HMPREF0733_RS03670
uniprot id: E3H287
names: Similarity
messages: Belongs to the asp23 family.

762948:HMPREF0733 RS00590
gene id: 762948:HMPREF0733_RS00590
uniprot id: E3H4W1
names: Similarity
messages: Belongs to the peptidase M24B family.

762948:HMPREF0733 RS07830
gene id: 762948:HMPREF0733_RS07830
uniprot id: E3H0T5
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

762948:HMPREF0733 RS02865
gene id: 762948:HMPREF0733_RS02865
uniprot id: E3H1D6
names: Function
names: Similarity
messages: Belongs to the BCKDHA family.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

762948:HMPREF0733 RS08315
gene id: 762948:HMPREF0733_RS08315
uniprot id: E3H1B3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

762948:HMPREF0733 RS01200
gene id: 762948:HMPREF0733_RS01200
uniprot id: E3H5M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.

762948:HMPREF0733 RS02450
gene id: 762948:HMPREF0733_RS02450
uniprot id: E3H0P4
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS07025
gene id: 762948:HMPREF0733_RS07025
uniprot id: E3GZX1
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS02715
gene id: 762948:HMPREF0733_RS02715
uniprot id: E3H125
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

762948:HMPREF0733 RS02520
gene id: 762948:HMPREF0733_RS02520
uniprot id: E3H0Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

762948:HMPREF0733 RS05340
gene id: 762948:HMPREF0733_RS05340
uniprot id: E3H487
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

762948:HMPREF0733 RS10155
gene id: 762948:HMPREF0733_RS10155
uniprot id: E3H3E2
names: Similarity
messages: Belongs to the Nudix hydrolase family.

762948:HMPREF0733 RS02230
gene id: 762948:HMPREF0733_RS02230
uniprot id: E3H0J8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

762948:HMPREF0733 RS03410
gene id: 762948:HMPREF0733_RS03410
uniprot id: E3H1W3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

762948:HMPREF0733 RS08000
gene id: 762948:HMPREF0733_RS08000
uniprot id: E3H0X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DivIVA family.
messages: Cytoplasm

762948:HMPREF0733 RS09490
gene id: 762948:HMPREF0733_RS09490
uniprot id: E3H2T7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

762948:HMPREF0733 RS06990
gene id: 762948:HMPREF0733_RS06990
uniprot id: E3GZW4
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

762948:HMPREF0733 RS06550
gene id: 762948:HMPREF0733_RS06550
uniprot id: E3H5Q8
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

762948:HMPREF0733 RS07865
gene id: 762948:HMPREF0733_RS07865
uniprot id: E3H0U2
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

762948:HMPREF0733 RS07265
gene id: 762948:HMPREF0733_RS07265
uniprot id: E3H097
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

762948:HMPREF0733 RS02805
gene id: 762948:HMPREF0733_RS02805
uniprot id: E3H146
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

762948:HMPREF0733 RS04750
gene id: 762948:HMPREF0733_RS04750
uniprot id: E3H3J6
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

762948:HMPREF0733 RS02830
gene id: 762948:HMPREF0733_RS02830
uniprot id: E3H1C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

762948:HMPREF0733 RS07525
gene id: 762948:HMPREF0733_RS07525
uniprot id: E3H0F0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

762948:HMPREF0733 RS03420
gene id: 762948:HMPREF0733_RS03420
uniprot id: E3H1W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

762948:HMPREF0733 RS00225
gene id: 762948:HMPREF0733_RS00225
uniprot id: E3H4F6
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS05430
gene id: 762948:HMPREF0733_RS05430
uniprot id: E3H4A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

762948:HMPREF0733 RS02945
gene id: 762948:HMPREF0733_RS02945
uniprot id: E3H1F4
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

762948:HMPREF0733 RS01180
gene id: 762948:HMPREF0733_RS01180
uniprot id: E3H5L9
names: Function
names: Similarity
messages: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.

762948:HMPREF0733 RS02855
gene id: 762948:HMPREF0733_RS02855
uniprot id: E3H1D4
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

762948:HMPREF0733 RS06200
gene id: 762948:HMPREF0733_RS06200
uniprot id: E3H564
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS03560
gene id: 762948:HMPREF0733_RS03560
uniprot id: E3H264
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

762948:HMPREF0733 RS08015
gene id: 762948:HMPREF0733_RS08015
uniprot id: E3H0X3
names: Subcellular Location Annotation
messages: Cytoplasm

762948:HMPREF0733 RS00660
gene id: 762948:HMPREF0733_RS00660
uniprot id: E3H4X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

762948:HMPREF0733 RS05625
gene id: 762948:HMPREF0733_RS05625
uniprot id: E3H4L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

762948:HMPREF0733 RS07835
gene id: 762948:HMPREF0733_RS07835
uniprot id: E3H0T6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

762948:HMPREF0733 RS07395
gene id: 762948:HMPREF0733_RS07395
uniprot id: E3H0C3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

762948:HMPREF0733 RS07995
gene id: 762948:HMPREF0733_RS07995
uniprot id: E3H0W8
names: Similarity
messages: Belongs to the YggT family.

762948:HMPREF0733 RS07115
gene id: 762948:HMPREF0733_RS07115
uniprot id: E3GZZ0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

762948:HMPREF0733 RS09425
gene id: 762948:HMPREF0733_RS09425
uniprot id: E3H2S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

762948:HMPREF0733 RS04660
gene id: 762948:HMPREF0733_RS04660
uniprot id: E3H3H4
names: Similarity
messages: Belongs to the LOR family.

762948:HMPREF0733 RS01505
gene id: 762948:HMPREF0733_RS01505
uniprot id: E3GZP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Membrane

762948:HMPREF0733 RS06515
gene id: 762948:HMPREF0733_RS06515
uniprot id: E3H5J8
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS03275
gene id: 762948:HMPREF0733_RS03275
uniprot id: E3H1T5
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS04320
gene id: 762948:HMPREF0733_RS04320
uniprot id: E3H327
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

762948:HMPREF0733 RS01340
gene id: 762948:HMPREF0733_RS01340
uniprot id: E3H5Q2
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

762948:HMPREF0733 RS04390
gene id: 762948:HMPREF0733_RS04390
uniprot id: E3H342
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

762948:HMPREF0733 RS00540
gene id: 762948:HMPREF0733_RS00540
uniprot id: E3H4U9
names: Function
names: Similarity
messages: Belongs to the HMBS family.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.

762948:HMPREF0733 RS09980
gene id: 762948:HMPREF0733_RS09980
uniprot id: E3H3A7
names: Function
messages: Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.

762948:HMPREF0733 RS04130
gene id: 762948:HMPREF0733_RS04130
uniprot id: E3H2R2
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS02200
gene id: 762948:HMPREF0733_RS02200
uniprot id: E3H0J2
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS04405
gene id: 762948:HMPREF0733_RS04405
uniprot id: E3H345
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS10165
gene id: 762948:HMPREF0733_RS10165
uniprot id: E3H3E4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

762948:HMPREF0733 RS03605
gene id: 762948:HMPREF0733_RS03605
uniprot id: E3H273
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS09880
gene id: 762948:HMPREF0733_RS09880
uniprot id: E3H384
names: Similarity
names: Subunit
messages: Belongs to the glutaminase family.
messages: Homotetramer.

762948:HMPREF0733 RS09565
gene id: 762948:HMPREF0733_RS09565
uniprot id: E3H2V2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

762948:HMPREF0733 RS03270
gene id: 762948:HMPREF0733_RS03270
uniprot id: E3H1T4
names: Similarity
messages: Belongs to the PhoU family.

762948:HMPREF0733 RS06290
gene id: 762948:HMPREF0733_RS06290
uniprot id: E3H5F2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

762948:HMPREF0733 RS09620
gene id: 762948:HMPREF0733_RS09620
uniprot id: E3H2W4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

762948:HMPREF0733 RS02020
gene id: 762948:HMPREF0733_RS02020
uniprot id: E3H075
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

762948:HMPREF0733 RS00030
gene id: 762948:HMPREF0733_RS00030
uniprot id: E3H441
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

762948:HMPREF0733 RS01890
gene id: 762948:HMPREF0733_RS01890
uniprot id: E3H047
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

762948:HMPREF0733 RS00125
gene id: 762948:HMPREF0733_RS00125
uniprot id: E3H4D6
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

762948:HMPREF0733 RS08665
gene id: 762948:HMPREF0733_RS08665
uniprot id: E3H1P6
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

762948:HMPREF0733 RS04545
gene id: 762948:HMPREF0733_RS04545
uniprot id: E3H3E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

762948:HMPREF0733 RS01895
gene id: 762948:HMPREF0733_RS01895
uniprot id: E3H048
names: Similarity
messages: Belongs to the catalase family.

762948:HMPREF0733 RS00080
gene id: 762948:HMPREF0733_RS00080
uniprot id: E3H450
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRP transporter (TC 2.A.7.5) family.
messages: Cell membrane
messages: Membrane

762948:HMPREF0733 RS00470
gene id: 762948:HMPREF0733_RS00470
uniprot id: E3H4T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

762948:HMPREF0733 RS09920
gene id: 762948:HMPREF0733_RS09920
uniprot id: E3H391
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

762948:HMPREF0733 RS05570
gene id: 762948:HMPREF0733_RS05570
uniprot id: E3H4K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

762948:HMPREF0733 RS05825
gene id: 762948:HMPREF0733_RS05825
uniprot id: E3H4R2
names: Similarity
messages: Belongs to the DyP-type peroxidase family.

762948:HMPREF0733 RS01225
gene id: 762948:HMPREF0733_RS01225
uniprot id: E3H5M9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.

762948:HMPREF0733 RS00330
gene id: 762948:HMPREF0733_RS00330
uniprot id: E3H4H8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

762948:HMPREF0733 RS08210
gene id: 762948:HMPREF0733_RS08210
uniprot id: E3H192
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

762948:HMPREF0733 RS09260
gene id: 762948:HMPREF0733_RS09260
uniprot id: E3H2F9
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS00005
gene id: 762948:HMPREF0733_RS00005
uniprot id: E3H436
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

762948:HMPREF0733 RS10205
gene id: 762948:HMPREF0733_RS10205
uniprot id: E3H3L8
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Monomer.

762948:HMPREF0733 RS05880
gene id: 762948:HMPREF0733_RS05880
uniprot id: E3H4S3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Monomer.

762948:HMPREF0733 RS07845
gene id: 762948:HMPREF0733_RS07845
uniprot id: E3H0T8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

762948:HMPREF0733 RS01365
gene id: 762948:HMPREF0733_RS01365
uniprot id: E3GZL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

762948:HMPREF0733 RS07125
gene id: 762948:HMPREF0733_RS07125
uniprot id: E3GZZ2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

762948:HMPREF0733 RS02725
gene id: 762948:HMPREF0733_RS02725
uniprot id: E3H127
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

762948:HMPREF0733 RS08450
gene id: 762948:HMPREF0733_RS08450
uniprot id: E3H1K8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

762948:HMPREF0733 RS01405
gene id: 762948:HMPREF0733_RS01405
uniprot id: E3GZM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

762948:HMPREF0733 RS02975
gene id: 762948:HMPREF0733_RS02975
uniprot id: E3H1G0
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

762948:HMPREF0733 RS00530
gene id: 762948:HMPREF0733_RS00530
uniprot id: E3H4U7
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

762948:HMPREF0733 RS08720
gene id: 762948:HMPREF0733_RS08720
uniprot id: E3H1Q7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

762948:HMPREF0733 RS01435
gene id: 762948:HMPREF0733_RS01435
uniprot id: E3GZM7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

762948:HMPREF0733 RS01430
gene id: 762948:HMPREF0733_RS01430
uniprot id: E3GZM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

762948:HMPREF0733 RS06830
gene id: 762948:HMPREF0733_RS06830
uniprot id: E3H5W4
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

762948:HMPREF0733 RS09505
gene id: 762948:HMPREF0733_RS09505
uniprot id: E3H2U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

762948:HMPREF0733 RS05975
gene id: 762948:HMPREF0733_RS05975
uniprot id: E3H522
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS08140
gene id: 762948:HMPREF0733_RS08140
uniprot id: E3H177
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

762948:HMPREF0733 RS07465
gene id: 762948:HMPREF0733_RS07465
uniprot id: E3H0D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

762948:HMPREF0733 RS05355
gene id: 762948:HMPREF0733_RS05355
uniprot id: E3H491
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

762948:HMPREF0733 RS08915
gene id: 762948:HMPREF0733_RS08915
uniprot id: E3H212
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

762948:HMPREF0733 RS01115
gene id: 762948:HMPREF0733_RS01115
uniprot id: E3H5K4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS05470
gene id: 762948:HMPREF0733_RS05470
uniprot id: E3H4B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

762948:HMPREF0733 RS07275
gene id: 762948:HMPREF0733_RS07275
uniprot id: E3H099
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS08960
gene id: 762948:HMPREF0733_RS08960
uniprot id: E3H222
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCCT transporter (TC 2.A.15) family.
messages: Membrane

762948:HMPREF0733 RS04135
gene id: 762948:HMPREF0733_RS04135
uniprot id: E3H2R3
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS01230
gene id: 762948:HMPREF0733_RS01230
uniprot id: E3H5N0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

762948:HMPREF0733 RS04125
gene id: 762948:HMPREF0733_RS04125
uniprot id: E3H2R1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport.

762948:HMPREF0733 RS03815
gene id: 762948:HMPREF0733_RS03815
uniprot id: E3H2J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

762948:HMPREF0733 RS07505
gene id: 762948:HMPREF0733_RS07505
uniprot id: E3H0E6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

762948:HMPREF0733 RS07040
gene id: 762948:HMPREF0733_RS07040
uniprot id: E3GZX4
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS08490
gene id: 762948:HMPREF0733_RS08490
uniprot id: E3H1L6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

762948:HMPREF0733 RS01260
gene id: 762948:HMPREF0733_RS01260
uniprot id: E3H5N6
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

762948:HMPREF0733 RS10495
gene id: 762948:HMPREF0733_RS10495
uniprot id: E3H3S4
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

762948:HMPREF0733 RS02390
gene id: 762948:HMPREF0733_RS02390
uniprot id: E3H0N1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

762948:HMPREF0733 RS04540
gene id: 762948:HMPREF0733_RS04540
uniprot id: E3H3E8
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS07710
gene id: 762948:HMPREF0733_RS07710
uniprot id: E3H0R1
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

762948:HMPREF0733 RS02205
gene id: 762948:HMPREF0733_RS02205
uniprot id: E3H0J3
names: Similarity
messages: Belongs to the GSP E family.

762948:HMPREF0733 RS01275
gene id: 762948:HMPREF0733_RS01275
uniprot id: E3H5N9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

762948:HMPREF0733 RS10335
gene id: 762948:HMPREF0733_RS10335
uniprot id: E3H3P4
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

762948:HMPREF0733 RS00805
gene id: 762948:HMPREF0733_RS00805
uniprot id: E3H580
names: Similarity
messages: Belongs to the peptidase S51 family.

762948:HMPREF0733 RS03150
gene id: 762948:HMPREF0733_RS03150
uniprot id: E3H1Q9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

762948:HMPREF0733 RS08930
gene id: 762948:HMPREF0733_RS08930
uniprot id: E3H215
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

762948:HMPREF0733 RS07825
gene id: 762948:HMPREF0733_RS07825
uniprot id: E3H0T4
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

762948:HMPREF0733 RS02300
gene id: 762948:HMPREF0733_RS02300
uniprot id: E3H0L3
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS07975
gene id: 762948:HMPREF0733_RS07975
uniprot id: E3H0W4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

762948:HMPREF0733 RS02910
gene id: 762948:HMPREF0733_RS02910
uniprot id: E3H1E5
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS07795
gene id: 762948:HMPREF0733_RS07795
uniprot id: E3H0S7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

762948:HMPREF0733 RS09670
gene id: 762948:HMPREF0733_RS09670
uniprot id: E3H2X4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

762948:HMPREF0733 RS06715
gene id: 762948:HMPREF0733_RS06715
uniprot id: E3H5U1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

762948:HMPREF0733 RS03710
gene id: 762948:HMPREF0733_RS03710
uniprot id: E3H295
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS08560
gene id: 762948:HMPREF0733_RS08560
uniprot id: E3H1M7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

762948:HMPREF0733 RS08635
gene id: 762948:HMPREF0733_RS08635
uniprot id: E3H1P0
names: Similarity
messages: Belongs to the DprA/Smf family.

762948:HMPREF0733 RS01695
gene id: 762948:HMPREF0733_RS01695
uniprot id: E3GZT1
names: Similarity
messages: Belongs to the ribonuclease N1/T1 family.

762948:HMPREF0733 RS08855
gene id: 762948:HMPREF0733_RS08855
uniprot id: E3H200
names: Function
messages: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.

762948:HMPREF0733 RS07630
gene id: 762948:HMPREF0733_RS07630
uniprot id: E3H0H1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

762948:HMPREF0733 RS01415
gene id: 762948:HMPREF0733_RS01415
uniprot id: E3GZM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

762948:HMPREF0733 RS09780
gene id: 762948:HMPREF0733_RS09780
uniprot id: E3H2Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.
messages: Membrane

762948:HMPREF0733 RS00685
gene id: 762948:HMPREF0733_RS00685
uniprot id: E3H4Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

762948:HMPREF0733 RS07615
gene id: 762948:HMPREF0733_RS07615
uniprot id: E3H0G8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DyP-type peroxidase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.
messages: Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact.

762948:HMPREF0733 RS09175
gene id: 762948:HMPREF0733_RS09175
uniprot id: E3H2E2
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

762948:HMPREF0733 RS01155
gene id: 762948:HMPREF0733_RS01155
uniprot id: E3H5L3
names: Similarity
messages: Belongs to the IMPDH/GMPR family.

762948:HMPREF0733 RS08455
gene id: 762948:HMPREF0733_RS08455
uniprot id: E3H1K9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

762948:HMPREF0733 RS09245
gene id: 762948:HMPREF0733_RS09245
uniprot id: E3H2F6
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS07485
gene id: 762948:HMPREF0733_RS07485
uniprot id: E3H0E2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

762948:HMPREF0733 RS02750
gene id: 762948:HMPREF0733_RS02750
uniprot id: E3H132
names: Similarity
messages: Belongs to the FemABX family.

762948:HMPREF0733 RS05590
gene id: 762948:HMPREF0733_RS05590
uniprot id: E3H4L2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS07945
gene id: 762948:HMPREF0733_RS07945
uniprot id: E3H0V8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

762948:HMPREF0733 RS07205
gene id: 762948:HMPREF0733_RS07205
uniprot id: E3H008
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

762948:HMPREF0733 RS06820
gene id: 762948:HMPREF0733_RS06820
uniprot id: E3H5W2
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

762948:HMPREF0733 RS09635
gene id: 762948:HMPREF0733_RS09635
uniprot id: E3H2W7
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Homodimer.

762948:HMPREF0733 RS00560
gene id: 762948:HMPREF0733_RS00560
uniprot id: E3H4V4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS00915
gene id: 762948:HMPREF0733_RS00915
uniprot id: E3H5A7
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

762948:HMPREF0733 RS09435
gene id: 762948:HMPREF0733_RS09435
uniprot id: E3H2S5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

762948:HMPREF0733 RS01645
gene id: 762948:HMPREF0733_RS01645
uniprot id: E3GZS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

762948:HMPREF0733 RS05760
gene id: 762948:HMPREF0733_RS05760
uniprot id: E3H4P8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

762948:HMPREF0733 RS03880
gene id: 762948:HMPREF0733_RS03880
uniprot id: E3H2L1
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

762948:HMPREF0733 RS05150
gene id: 762948:HMPREF0733_RS05150
uniprot id: E3H405
names: Similarity
messages: Belongs to the peptidase M18 family.

762948:HMPREF0733 RS04380
gene id: 762948:HMPREF0733_RS04380
uniprot id: E3H340
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS07080
gene id: 762948:HMPREF0733_RS07080
uniprot id: E3GZY3
names: Similarity
messages: Belongs to the YciI family.

762948:HMPREF0733 RS01880
gene id: 762948:HMPREF0733_RS01880
uniprot id: E3H044
names: Similarity
messages: Belongs to the UPF0234 family.

762948:HMPREF0733 RS01395
gene id: 762948:HMPREF0733_RS01395
uniprot id: E3GZL9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

762948:HMPREF0733 RS09310
gene id: 762948:HMPREF0733_RS09310
uniprot id: E3H2G9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

762948:HMPREF0733 RS01545
gene id: 762948:HMPREF0733_RS01545
uniprot id: E3GZQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

762948:HMPREF0733 RS05375
gene id: 762948:HMPREF0733_RS05375
uniprot id: E3H496
names: Function
names: Similarity
names: Subunit
messages: Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
messages: Belongs to the AhpD family.
messages: Homotrimer.

762948:HMPREF0733 RS07725
gene id: 762948:HMPREF0733_RS07725
uniprot id: E3H0R4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

762948:HMPREF0733 RS01565
gene id: 762948:HMPREF0733_RS01565
uniprot id: E3GZQ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

762948:HMPREF0733 RS01640
gene id: 762948:HMPREF0733_RS01640
uniprot id: E3GZS1
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

762948:HMPREF0733 RS10225
gene id: 762948:HMPREF0733_RS10225
uniprot id: E3H3M2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

762948:HMPREF0733 RS01165
gene id: 762948:HMPREF0733_RS01165
uniprot id: E3H5L5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

762948:HMPREF0733 RS09045
gene id: 762948:HMPREF0733_RS09045
uniprot id: E3H2B6
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

762948:HMPREF0733 RS00860
gene id: 762948:HMPREF0733_RS00860
uniprot id: E3H592
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

762948:HMPREF0733 RS05565
gene id: 762948:HMPREF0733_RS05565
uniprot id: E3H4K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

762948:HMPREF0733 RS08125
gene id: 762948:HMPREF0733_RS08125
uniprot id: E3H174
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

762948:HMPREF0733 RS02670
gene id: 762948:HMPREF0733_RS02670
uniprot id: E3H115
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

762948:HMPREF0733 RS08615
gene id: 762948:HMPREF0733_RS08615
uniprot id: E3H1N6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

762948:HMPREF0733 RS09205
gene id: 762948:HMPREF0733_RS09205
uniprot id: E3H2E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Membrane
messages: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

762948:HMPREF0733 RS09915
gene id: 762948:HMPREF0733_RS09915
uniprot id: E3H390
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

762948:HMPREF0733 RS04725
gene id: 762948:HMPREF0733_RS04725
uniprot id: E3H3J0
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.
messages: Reversible hydration of carbon dioxide.

762948:HMPREF0733 RS07155
gene id: 762948:HMPREF0733_RS07155
uniprot id: E3GZZ8
names: Similarity
messages: Belongs to the AHA1 family.

762948:HMPREF0733 RS08445
gene id: 762948:HMPREF0733_RS08445
uniprot id: E3H1K7
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS10535
gene id: 762948:HMPREF0733_RS10535
uniprot id: E3H412
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS01265
gene id: 762948:HMPREF0733_RS01265
uniprot id: E3H5N7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

762948:HMPREF0733 RS07700
gene id: 762948:HMPREF0733_RS07700
uniprot id: E3H0Q9
names: Similarity
messages: Belongs to the TlyA family.

762948:HMPREF0733 RS07905
gene id: 762948:HMPREF0733_RS07905
uniprot id: E3H0V0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

762948:HMPREF0733 RS05970
gene id: 762948:HMPREF0733_RS05970
uniprot id: E3H521
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

762948:HMPREF0733 RS04265
gene id: 762948:HMPREF0733_RS04265
uniprot id: E3H315
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

762948:HMPREF0733 RS09025
gene id: 762948:HMPREF0733_RS09025
uniprot id: E3H235
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS01335
gene id: 762948:HMPREF0733_RS01335
uniprot id: E3H5Q1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

762948:HMPREF0733 RS01490
gene id: 762948:HMPREF0733_RS01490
uniprot id: E3GZP0
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

762948:HMPREF0733 RS02845
gene id: 762948:HMPREF0733_RS02845
uniprot id: E3H1D2
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

762948:HMPREF0733 RS00065
gene id: 762948:HMPREF0733_RS00065
uniprot id: E3H448
names: Similarity
messages: Belongs to the glutamine synthetase family.

762948:HMPREF0733 RS01385
gene id: 762948:HMPREF0733_RS01385
uniprot id: E3GZL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

762948:HMPREF0733 RS02645
gene id: 762948:HMPREF0733_RS02645
uniprot id: E3H110
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

762948:HMPREF0733 RS04350
gene id: 762948:HMPREF0733_RS04350
uniprot id: E3H333
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS00940
gene id: 762948:HMPREF0733_RS00940
uniprot id: E3H5B2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

762948:HMPREF0733 RS08480
gene id: 762948:HMPREF0733_RS08480
uniprot id: E3H1L4
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

762948:HMPREF0733 RS07915
gene id: 762948:HMPREF0733_RS07915
uniprot id: E3H0V2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

762948:HMPREF0733 RS07510
gene id: 762948:HMPREF0733_RS07510
uniprot id: E3H0E7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

762948:HMPREF0733 RS01360
gene id: 762948:HMPREF0733_RS01360
uniprot id: E3H5Q6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

762948:HMPREF0733 RS02455
gene id: 762948:HMPREF0733_RS02455
uniprot id: E3H0P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

762948:HMPREF0733 RS00705
gene id: 762948:HMPREF0733_RS00705
uniprot id: E3H4Y6
names: Similarity
messages: Belongs to the peptidase C15 family.

762948:HMPREF0733 RS00995
gene id: 762948:HMPREF0733_RS00995
uniprot id: E3H5C3
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

762948:HMPREF0733 RS08285
gene id: 762948:HMPREF0733_RS08285
uniprot id: E3H1A7
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

762948:HMPREF0733 RS00115
gene id: 762948:HMPREF0733_RS00115
uniprot id: E3H4D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

762948:HMPREF0733 RS06600
gene id: 762948:HMPREF0733_RS06600
uniprot id: E3H5R8
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.

762948:HMPREF0733 RS02095
gene id: 762948:HMPREF0733_RS02095
uniprot id: E3H090
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS05855
gene id: 762948:HMPREF0733_RS05855
uniprot id: E3H4R8
names: Similarity
messages: Belongs to the adrenodoxin/putidaredoxin family.

762948:HMPREF0733 RS07335
gene id: 762948:HMPREF0733_RS07335
uniprot id: E3H0B1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

762948:HMPREF0733 RS03485
gene id: 762948:HMPREF0733_RS03485
uniprot id: E3H243
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

762948:HMPREF0733 RS00020
gene id: 762948:HMPREF0733_RS00020
uniprot id: E3H439
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

762948:HMPREF0733 RS07320
gene id: 762948:HMPREF0733_RS07320
uniprot id: E3H0A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

762948:HMPREF0733 RS01990
gene id: 762948:HMPREF0733_RS01990
uniprot id: E3H068
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell membrane
messages: Membrane

762948:HMPREF0733 RS10485
gene id: 762948:HMPREF0733_RS10485
uniprot id: E3H3S2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

762948:HMPREF0733 RS00445
gene id: 762948:HMPREF0733_RS00445
uniprot id: E3H4S9
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

762948:HMPREF0733 RS02010
gene id: 762948:HMPREF0733_RS02010
uniprot id: E3H073
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS03615
gene id: 762948:HMPREF0733_RS03615
uniprot id: E3H275
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane
messages: Membrane

762948:HMPREF0733 RS09560
gene id: 762948:HMPREF0733_RS09560
uniprot id: E3H2V1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

762948:HMPREF0733 RS07595
gene id: 762948:HMPREF0733_RS07595
uniprot id: E3H0G4
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS08710
gene id: 762948:HMPREF0733_RS08710
uniprot id: E3H1Q5
names: Similarity
messages: Belongs to the TrpC family.

762948:HMPREF0733 RS07285
gene id: 762948:HMPREF0733_RS07285
uniprot id: E3H0A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

762948:HMPREF0733 RS00670
gene id: 762948:HMPREF0733_RS00670
uniprot id: E3H4X8
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

762948:HMPREF0733 RS07750
gene id: 762948:HMPREF0733_RS07750
uniprot id: E3H0R9
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

762948:HMPREF0733 RS04240
gene id: 762948:HMPREF0733_RS04240
uniprot id: E3H313
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

762948:HMPREF0733 RS04385
gene id: 762948:HMPREF0733_RS04385
uniprot id: E3H341
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

762948:HMPREF0733 RS07035
gene id: 762948:HMPREF0733_RS07035
uniprot id: E3GZX3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

762948:HMPREF0733 RS03840
gene id: 762948:HMPREF0733_RS03840
uniprot id: E3H2K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

762948:HMPREF0733 RS08300
gene id: 762948:HMPREF0733_RS08300
uniprot id: E3H1B0
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

762948:HMPREF0733 RS10265
gene id: 762948:HMPREF0733_RS10265
uniprot id: E3H3N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

762948:HMPREF0733 RS08175
gene id: 762948:HMPREF0733_RS08175
uniprot id: E3H185
names: Similarity
messages: Belongs to the polysaccharide synthase family.

762948:HMPREF0733 RS10185
gene id: 762948:HMPREF0733_RS10185
uniprot id: E3H3L4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

762948:HMPREF0733 RS10015
gene id: 762948:HMPREF0733_RS10015
uniprot id: E3H3B4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

762948:HMPREF0733 RS05155
gene id: 762948:HMPREF0733_RS05155
uniprot id: E3H406
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS08660
gene id: 762948:HMPREF0733_RS08660
uniprot id: E3H1P5
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

762948:HMPREF0733 RS08575
gene id: 762948:HMPREF0733_RS08575
uniprot id: E3H1M9
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS00715
gene id: 762948:HMPREF0733_RS00715
uniprot id: E3H4Y8
names: Similarity
messages: Belongs to the LOG family.

762948:HMPREF0733 RS08135
gene id: 762948:HMPREF0733_RS08135
uniprot id: E3H176
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

762948:HMPREF0733 RS08610
gene id: 762948:HMPREF0733_RS08610
uniprot id: E3H1N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

762948:HMPREF0733 RS09010
gene id: 762948:HMPREF0733_RS09010
uniprot id: E3H232
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 2 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

762948:HMPREF0733 RS01900
gene id: 762948:HMPREF0733_RS01900
uniprot id: E3H049
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS05195
gene id: 762948:HMPREF0733_RS05195
uniprot id: E3H454
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

762948:HMPREF0733 RS00760
gene id: 762948:HMPREF0733_RS00760
uniprot id: E3H4Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

762948:HMPREF0733 RS10175
gene id: 762948:HMPREF0733_RS10175
uniprot id: E3H3E6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

762948:HMPREF0733 RS00130
gene id: 762948:HMPREF0733_RS00130
uniprot id: E3H4D7
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS05680
gene id: 762948:HMPREF0733_RS05680
uniprot id: E3H4N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

762948:HMPREF0733 RS04555
gene id: 762948:HMPREF0733_RS04555
uniprot id: E3H3F1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

762948:HMPREF0733 RS06505
gene id: 762948:HMPREF0733_RS06505
uniprot id: E3H5J7
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

762948:HMPREF0733 RS05015
gene id: 762948:HMPREF0733_RS05015
uniprot id: E3H3X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

762948:HMPREF0733 RS10120
gene id: 762948:HMPREF0733_RS10120
uniprot id: E3H3D5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

762948:HMPREF0733 RS02035
gene id: 762948:HMPREF0733_RS02035
uniprot id: E3H078
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS02880
gene id: 762948:HMPREF0733_RS02880
uniprot id: E3H1D9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

762948:HMPREF0733 RS08860
gene id: 762948:HMPREF0733_RS08860
uniprot id: E3H201
names: Similarity
messages: Belongs to the HsdR family.

762948:HMPREF0733 RS00545
gene id: 762948:HMPREF0733_RS00545
uniprot id: E3H4V0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS10140
gene id: 762948:HMPREF0733_RS10140
uniprot id: E3H3D9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

762948:HMPREF0733 RS01110
gene id: 762948:HMPREF0733_RS01110
uniprot id: E3H5E7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

762948:HMPREF0733 RS00045
gene id: 762948:HMPREF0733_RS00045
uniprot id: E3H444
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

762948:HMPREF0733 RS07665
gene id: 762948:HMPREF0733_RS07665
uniprot id: E3H0Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

762948:HMPREF0733 RS01455
gene id: 762948:HMPREF0733_RS01455
uniprot id: E3GZN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

762948:HMPREF0733 RS01255
gene id: 762948:HMPREF0733_RS01255
uniprot id: E3H5N5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

762948:HMPREF0733 RS01970
gene id: 762948:HMPREF0733_RS01970
uniprot id: E3H064
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
messages: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).

762948:HMPREF0733 RS10630
gene id: 762948:HMPREF0733_RS10630
uniprot id: E3H431
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

762948:HMPREF0733 RS09185
gene id: 762948:HMPREF0733_RS09185
uniprot id: E3H2E4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

762948:HMPREF0733 RS01500
gene id: 762948:HMPREF0733_RS01500
uniprot id: E3GZP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

762948:HMPREF0733 RS02615
gene id: 762948:HMPREF0733_RS02615
uniprot id: E3H104
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

762948:HMPREF0733 RS08765
gene id: 762948:HMPREF0733_RS08765
uniprot id: E3H1X8
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS10520
gene id: 762948:HMPREF0733_RS10520
uniprot id: E3H3T0
names: Similarity
messages: Belongs to the ABC transporter superfamily.

762948:HMPREF0733 RS04465
gene id: 762948:HMPREF0733_RS04465
uniprot id: E3H357
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

762948:HMPREF0733 RS09375
gene id: 762948:HMPREF0733_RS09375
uniprot id: E3H2I3
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

762948:HMPREF0733 RS05805
gene id: 762948:HMPREF0733_RS05805
uniprot id: E3H4Q8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS07540
gene id: 762948:HMPREF0733_RS07540
uniprot id: E3H0F3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

762948:HMPREF0733 RS09690
gene id: 762948:HMPREF0733_RS09690
uniprot id: E3H2X8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MurCDEF family. MurT subfamily.
messages: Forms a heterodimer with GatD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.

762948:HMPREF0733 RS06555
gene id: 762948:HMPREF0733_RS06555
uniprot id: E3H5Q9
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

762948:HMPREF0733 RS07295
gene id: 762948:HMPREF0733_RS07295
uniprot id: E3H0A3
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS00270
gene id: 762948:HMPREF0733_RS00270
uniprot id: E3H4G6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

762948:HMPREF0733 RS02175
gene id: 762948:HMPREF0733_RS02175
uniprot id: E3H0I7
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

762948:HMPREF0733 RS07280
gene id: 762948:HMPREF0733_RS07280
uniprot id: E3H0A0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

762948:HMPREF0733 RS09960
gene id: 762948:HMPREF0733_RS09960
uniprot id: E3H3A0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

762948:HMPREF0733 RS07560
gene id: 762948:HMPREF0733_RS07560
uniprot id: E3H0F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

762948:HMPREF0733 RS07185
gene id: 762948:HMPREF0733_RS07185
uniprot id: E3H004
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

762948:HMPREF0733 RS06220
gene id: 762948:HMPREF0733_RS06220
uniprot id: E3H567
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS06620
gene id: 762948:HMPREF0733_RS06620
uniprot id: E3H5S2
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

762948:HMPREF0733 RS07900
gene id: 762948:HMPREF0733_RS07900
uniprot id: E3H0U9
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

762948:HMPREF0733 RS05890
gene id: 762948:HMPREF0733_RS05890
uniprot id: E3H505
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS09685
gene id: 762948:HMPREF0733_RS09685
uniprot id: E3H2X7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

762948:HMPREF0733 RS09140
gene id: 762948:HMPREF0733_RS09140
uniprot id: E3H2D6
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

762948:HMPREF0733 RS08380
gene id: 762948:HMPREF0733_RS08380
uniprot id: E3H1C8
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

762948:HMPREF0733 RS09615
gene id: 762948:HMPREF0733_RS09615
uniprot id: E3H2W3
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

762948:HMPREF0733 RS09610
gene id: 762948:HMPREF0733_RS09610
uniprot id: E3H2W2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

762948:HMPREF0733 RS01790
gene id: 762948:HMPREF0733_RS01790
uniprot id: E3H029
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS04560
gene id: 762948:HMPREF0733_RS04560
uniprot id: E3H3F2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

762948:HMPREF0733 RS09005
gene id: 762948:HMPREF0733_RS09005
uniprot id: E3H231
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS01235
gene id: 762948:HMPREF0733_RS01235
uniprot id: E3H5N1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

762948:HMPREF0733 RS05285
gene id: 762948:HMPREF0733_RS05285
uniprot id: E3H476
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

762948:HMPREF0733 RS01560
gene id: 762948:HMPREF0733_RS01560
uniprot id: E3GZQ4
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

762948:HMPREF0733 RS04330
gene id: 762948:HMPREF0733_RS04330
uniprot id: E3H329
names: Similarity
messages: Belongs to the ParB family.

762948:HMPREF0733 RS09360
gene id: 762948:HMPREF0733_RS09360
uniprot id: E3H2I0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
messages: Monomer.

762948:HMPREF0733 RS01330
gene id: 762948:HMPREF0733_RS01330
uniprot id: E3H5Q0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

762948:HMPREF0733 RS00430
gene id: 762948:HMPREF0733_RS00430
uniprot id: E3H4S6
names: Similarity
messages: Belongs to the peptidase S16 family.

762948:HMPREF0733 RS04370
gene id: 762948:HMPREF0733_RS04370
uniprot id: E3H337
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS10550
gene id: 762948:HMPREF0733_RS10550
uniprot id: E3H415
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS01055
gene id: 762948:HMPREF0733_RS01055
uniprot id: E3H5D5
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

762948:HMPREF0733 RS05070
gene id: 762948:HMPREF0733_RS05070
uniprot id: E3H3Y5
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS10800
gene id: 762948:HMPREF0733_RS10800
uniprot id: E3H204
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

762948:HMPREF0733 RS03600
gene id: 762948:HMPREF0733_RS03600
uniprot id: E3H272
names: Similarity
messages: Belongs to the CsoR family.

762948:HMPREF0733 RS03320
gene id: 762948:HMPREF0733_RS03320
uniprot id: E3H1U4
names: Similarity
messages: Belongs to the Nth/MutY family.

762948:HMPREF0733 RS07270
gene id: 762948:HMPREF0733_RS07270
uniprot id: E3H098
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

762948:HMPREF0733 RS05725
gene id: 762948:HMPREF0733_RS05725
uniprot id: E3H4P1
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.

762948:HMPREF0733 RS09985
gene id: 762948:HMPREF0733_RS09985
uniprot id: E3H3A8
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

762948:HMPREF0733 RS03585
gene id: 762948:HMPREF0733_RS03585
uniprot id: E3H269
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the CobB/CobQ family.
messages: Involved in acetate metabolism.
messages: The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site.

762948:HMPREF0733 RS08940
gene id: 762948:HMPREF0733_RS08940
uniprot id: E3H218
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

762948:HMPREF0733 RS00955
gene id: 762948:HMPREF0733_RS00955
uniprot id: E3H5B5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

762948:HMPREF0733 RS10595
gene id: 762948:HMPREF0733_RS10595
uniprot id: E3H423
names: Similarity
messages: Belongs to the MQO family.

762948:HMPREF0733 RS04470
gene id: 762948:HMPREF0733_RS04470
uniprot id: E3H358
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

762948:HMPREF0733 RS02040
gene id: 762948:HMPREF0733_RS02040
uniprot id: E3H079
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS01670
gene id: 762948:HMPREF0733_RS01670
uniprot id: E3GZS6
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
messages: Belongs to the nitrobindin family.
messages: Binds 1 heme b group per subunit, that coordinates a highly solvent-exposed Fe(III) atom.
messages: Forms a 10-stranded antiparallel beta-barrel structure able to accommodate a hydrophobic ligand in its interior. In fact, this fold hosts the heme group, which is located in a wide surface cleft.
messages: Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS02820
gene id: 762948:HMPREF0733_RS02820
uniprot id: E3H150
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

762948:HMPREF0733 RS05295
gene id: 762948:HMPREF0733_RS05295
uniprot id: E3H478
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

762948:HMPREF0733 RS09135
gene id: 762948:HMPREF0733_RS09135
uniprot id: E3H2D5
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

762948:HMPREF0733 RS07815
gene id: 762948:HMPREF0733_RS07815
uniprot id: E3H0T2
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

762948:HMPREF0733 RS06030
gene id: 762948:HMPREF0733_RS06030
uniprot id: E3H530
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

762948:HMPREF0733 RS08650
gene id: 762948:HMPREF0733_RS08650
uniprot id: E3H1P3
names: Similarity
messages: Belongs to the thiolase-like superfamily. FabH family.

762948:HMPREF0733 RS04055
gene id: 762948:HMPREF0733_RS04055
uniprot id: E3H2P7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

762948:HMPREF0733 RS01605
gene id: 762948:HMPREF0733_RS01605
uniprot id: E3GZR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

762948:HMPREF0733 RS01625
gene id: 762948:HMPREF0733_RS01625
uniprot id: E3GZR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

762948:HMPREF0733 RS01205
gene id: 762948:HMPREF0733_RS01205
uniprot id: E3H5M4
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

762948:HMPREF0733 RS01765
gene id: 762948:HMPREF0733_RS01765
uniprot id: E3H024
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

762948:HMPREF0733 RS09265
gene id: 762948:HMPREF0733_RS09265
uniprot id: E3H2G0
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

762948:HMPREF0733 RS10215
gene id: 762948:HMPREF0733_RS10215
uniprot id: E3H3M0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

762948:HMPREF0733 RS05230
gene id: 762948:HMPREF0733_RS05230
uniprot id: E3H462
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

762948:HMPREF0733 RS02765
gene id: 762948:HMPREF0733_RS02765
uniprot id: E3H136
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

762948:HMPREF0733 RS02090
gene id: 762948:HMPREF0733_RS02090
uniprot id: E3H089
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

762948:HMPREF0733 RS02920
gene id: 762948:HMPREF0733_RS02920
uniprot id: E3H1E8
names: Similarity
messages: Belongs to the glycosyl hydrolase 24 family.

762948:HMPREF0733 RS03430
gene id: 762948:HMPREF0733_RS03430
uniprot id: E3H1W7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

762948:HMPREF0733 RS06565
gene id: 762948:HMPREF0733_RS06565
uniprot id: E3H5R1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.
messages: Belongs to the MshB deacetylase family. Mca subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Monomer.

762948:HMPREF0733 RS08935
gene id: 762948:HMPREF0733_RS08935
uniprot id: E3H217
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm

762948:HMPREF0733 RS02400
gene id: 762948:HMPREF0733_RS02400
uniprot id: E3H0N3
names: Similarity
messages: Belongs to the SAICAR synthetase family.

762948:HMPREF0733 RS01850
gene id: 762948:HMPREF0733_RS01850
uniprot id: E3H039
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.

762948:HMPREF0733 RS05055
gene id: 762948:HMPREF0733_RS05055
uniprot id: E3H3Y1
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS09835
gene id: 762948:HMPREF0733_RS09835
uniprot id: E3H375
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

762948:HMPREF0733 RS09905
gene id: 762948:HMPREF0733_RS09905
uniprot id: E3H388
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

762948:HMPREF0733 RS01495
gene id: 762948:HMPREF0733_RS01495
uniprot id: E3GZP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

762948:HMPREF0733 RS03790
gene id: 762948:HMPREF0733_RS03790
uniprot id: E3H2J3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS07315
gene id: 762948:HMPREF0733_RS07315
uniprot id: E3H0A7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

762948:HMPREF0733 RS00025
gene id: 762948:HMPREF0733_RS00025
uniprot id: E3H440
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

762948:HMPREF0733 RS08250
gene id: 762948:HMPREF0733_RS08250
uniprot id: E3H1A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

762948:HMPREF0733 RS01310
gene id: 762948:HMPREF0733_RS01310
uniprot id: E3H5P6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

762948:HMPREF0733 RS01025
gene id: 762948:HMPREF0733_RS01025
uniprot id: E3H5C9
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS05735
gene id: 762948:HMPREF0733_RS05735
uniprot id: E3H4P3
names: Similarity
messages: Belongs to the DnaX/STICHEL family.

762948:HMPREF0733 RS04570
gene id: 762948:HMPREF0733_RS04570
uniprot id: E3H3F6
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

762948:HMPREF0733 RS02555
gene id: 762948:HMPREF0733_RS02555
uniprot id: E3H0Z1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

762948:HMPREF0733 RS01815
gene id: 762948:HMPREF0733_RS01815
uniprot id: E3H034
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

762948:HMPREF0733 RS08840
gene id: 762948:HMPREF0733_RS08840
uniprot id: E3H1Z7
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS10600
gene id: 762948:HMPREF0733_RS10600
uniprot id: E3H424
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS02215
gene id: 762948:HMPREF0733_RS02215
uniprot id: E3H0J5
names: Similarity
messages: Belongs to the DNA polymerase type-A family.

762948:HMPREF0733 RS01525
gene id: 762948:HMPREF0733_RS01525
uniprot id: E3GZP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Cell membrane
messages: Membrane

762948:HMPREF0733 RS03305
gene id: 762948:HMPREF0733_RS03305
uniprot id: E3H1U1
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

762948:HMPREF0733 RS06405
gene id: 762948:HMPREF0733_RS06405
uniprot id: E3H5H5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

762948:HMPREF0733 RS00555
gene id: 762948:HMPREF0733_RS00555
uniprot id: E3H4V3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.

762948:HMPREF0733 RS09465
gene id: 762948:HMPREF0733_RS09465
uniprot id: E3H2T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

762948:HMPREF0733 RS01660
gene id: 762948:HMPREF0733_RS01660
uniprot id: E3GZS4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

762948:HMPREF0733 RS01610
gene id: 762948:HMPREF0733_RS01610
uniprot id: E3GZR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

762948:HMPREF0733 RS09555
gene id: 762948:HMPREF0733_RS09555
uniprot id: E3H2V0
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

762948:HMPREF0733 RS10035
gene id: 762948:HMPREF0733_RS10035
uniprot id: E3H3B8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

762948:HMPREF0733 RS03450
gene id: 762948:HMPREF0733_RS03450
uniprot id: E3H236
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

762948:HMPREF0733 RS07460
gene id: 762948:HMPREF0733_RS07460
uniprot id: E3H0D7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.
messages: Homohexamer. Forms a ring that surrounds DNA.
messages: Membrane

762948:HMPREF0733 RS10530
gene id: 762948:HMPREF0733_RS10530
uniprot id: E3H3T2
names: Similarity
messages: Belongs to the ABC transporter superfamily.

762948:HMPREF0733 RS02295
gene id: 762948:HMPREF0733_RS02295
uniprot id: E3H0L2
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS00220
gene id: 762948:HMPREF0733_RS00220
uniprot id: E3H4F5
names: Subcellular Location Annotation
messages: Membrane

762948:HMPREF0733 RS02655
gene id: 762948:HMPREF0733_RS02655
uniprot id: E3H112
names: Similarity
messages: Belongs to the isochorismate synthase family.

762948:HMPREF0733 RS01400
gene id: 762948:HMPREF0733_RS01400
uniprot id: E3GZM0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

762948:HMPREF0733 RS09895
gene id: 762948:HMPREF0733_RS09895
uniprot id: E3H386
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

762948:HMPREF0733 RS09340
gene id: 762948:HMPREF0733_RS09340
uniprot id: E3H2H6
names: Similarity
messages: Belongs to the prokaryotic ubiquitin-like protein family.