748449:HALHA RS08700
gene id: 748449:HALHA_RS08700
uniprot id: L0K8V0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

748449:HALHA RS08645
gene id: 748449:HALHA_RS08645
uniprot id: L0K9K9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

748449:HALHA RS09890
gene id: 748449:HALHA_RS09890
uniprot id: L0KCX0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

748449:HALHA RS03210
gene id: 748449:HALHA_RS03210
uniprot id: L0K929
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cytoplasm

748449:HALHA RS01030
gene id: 748449:HALHA_RS01030
uniprot id: L0K768
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

748449:HALHA RS09805
gene id: 748449:HALHA_RS09805
uniprot id: L0KA82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

748449:HALHA RS12660
gene id: 748449:HALHA_RS12660
uniprot id: L0KEG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

748449:HALHA RS09695
gene id: 748449:HALHA_RS09695
uniprot id: L0KBZ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

748449:HALHA RS09730
gene id: 748449:HALHA_RS09730
uniprot id: L0KA69
names: Similarity
messages: Belongs to the transpeptidase family.

748449:HALHA RS07395
gene id: 748449:HALHA_RS07395
uniprot id: L0KA88
names: Similarity
messages: Belongs to the ComB family.

748449:HALHA RS05830
gene id: 748449:HALHA_RS05830
uniprot id: L0K9B0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdgT transporter family.
messages: Catalyzes the proton-dependent uptake of 2-keto-3-deoxygluconate (KDG) into the cell.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS05840
gene id: 748449:HALHA_RS05840
uniprot id: L0K775
names: Similarity
names: Subunit
messages: Belongs to the PdxA family. PdxA2 subfamily.
messages: Homodimer.

748449:HALHA RS03990
gene id: 748449:HALHA_RS03990
uniprot id: L0K8X1
names: Similarity
messages: Belongs to the P(II) protein family.

748449:HALHA RS07715
gene id: 748449:HALHA_RS07715
uniprot id: L0KBP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.
messages: Homodimer.

748449:HALHA RS10660
gene id: 748449:HALHA_RS10660
uniprot id: L0K9S4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

748449:HALHA RS11605
gene id: 748449:HALHA_RS11605
uniprot id: L0KCG9
names: Similarity
messages: Belongs to the HepT RNase toxin family.

748449:HALHA RS06535
gene id: 748449:HALHA_RS06535
uniprot id: L0KB15
names: Similarity
messages: Belongs to the glycosyl hydrolase 42 family.

748449:HALHA RS08410
gene id: 748449:HALHA_RS08410
uniprot id: L0KC39
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS07400
gene id: 748449:HALHA_RS07400
uniprot id: L0K8W1
names: Similarity
messages: Belongs to the phosphosulfolactate synthase family.

748449:HALHA RS03900
gene id: 748449:HALHA_RS03900
uniprot id: L0K676
names: Similarity
messages: Belongs to the UPF0236 family.

748449:HALHA RS03970
gene id: 748449:HALHA_RS03970
uniprot id: L0K711
names: Similarity
messages: Belongs to the asparagine synthetase family.

748449:HALHA RS03600
gene id: 748449:HALHA_RS03600
uniprot id: L0K604
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

748449:HALHA RS03030
gene id: 748449:HALHA_RS03030
uniprot id: L0K7R1
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

748449:HALHA RS01255
gene id: 748449:HALHA_RS01255
uniprot id: L0K7C2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

748449:HALHA RS12600
gene id: 748449:HALHA_RS12600
uniprot id: L0KBR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

748449:HALHA RS01125
gene id: 748449:HALHA_RS01125
uniprot id: L0K7Y9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS03380
gene id: 748449:HALHA_RS03380
uniprot id: L0K5V6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

748449:HALHA RS10130
gene id: 748449:HALHA_RS10130
uniprot id: L0KAD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

748449:HALHA RS07375
gene id: 748449:HALHA_RS07375
uniprot id: L0K8V7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0756 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS08305
gene id: 748449:HALHA_RS08305
uniprot id: L0K9D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

748449:HALHA RS00700
gene id: 748449:HALHA_RS00700
uniprot id: L0K702
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

748449:HALHA RS03435
gene id: 748449:HALHA_RS03435
uniprot id: L0K978
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. DnaE subfamily.
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase.
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

748449:HALHA RS08365
gene id: 748449:HALHA_RS08365
uniprot id: L0KC28
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

748449:HALHA RS12060
gene id: 748449:HALHA_RS12060
uniprot id: L0KBG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

748449:HALHA RS00330
gene id: 748449:HALHA_RS00330
uniprot id: L0K473
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

748449:HALHA RS00520
gene id: 748449:HALHA_RS00520
uniprot id: L0K528
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

748449:HALHA RS10985
gene id: 748449:HALHA_RS10985
uniprot id: L0KCK9
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

748449:HALHA RS08040
gene id: 748449:HALHA_RS08040
uniprot id: L0KB26
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

748449:HALHA RS06990
gene id: 748449:HALHA_RS06990
uniprot id: L0KAI2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

748449:HALHA RS01190
gene id: 748449:HALHA_RS01190
uniprot id: L0K5F5
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

748449:HALHA RS02025
gene id: 748449:HALHA_RS02025
uniprot id: L0K789
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Cytoplasm

748449:HALHA RS08655
gene id: 748449:HALHA_RS08655
uniprot id: L0KC98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

748449:HALHA RS02500
gene id: 748449:HALHA_RS02500
uniprot id: L0K7Z8
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

748449:HALHA RS07005
gene id: 748449:HALHA_RS07005
uniprot id: L0K7Y2
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

748449:HALHA RS00825
gene id: 748449:HALHA_RS00825
uniprot id: L0K6L6
names: Function
names: Similarity
names: Subunit
messages: Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization.
messages: Belongs to the HutP family.
messages: Homohexamer.

748449:HALHA RS08900
gene id: 748449:HALHA_RS08900
uniprot id: L0KCC5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS10325
gene id: 748449:HALHA_RS10325
uniprot id: L0KAF5
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

748449:HALHA RS09125
gene id: 748449:HALHA_RS09125
uniprot id: L0KCH7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

748449:HALHA RS04330
gene id: 748449:HALHA_RS04330
uniprot id: L0K9T2
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

748449:HALHA RS12290
gene id: 748449:HALHA_RS12290
uniprot id: L0KAS1
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

748449:HALHA RS12370
gene id: 748449:HALHA_RS12370
uniprot id: L0KEA8
names: Function
messages: Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.

748449:HALHA RS07725
gene id: 748449:HALHA_RS07725
uniprot id: L0KAE5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

748449:HALHA RS10645
gene id: 748449:HALHA_RS10645
uniprot id: L0KBX9
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

748449:HALHA RS12705
gene id: 748449:HALHA_RS12705
uniprot id: L0KAZ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.

748449:HALHA RS02175
gene id: 748449:HALHA_RS02175
uniprot id: L0K8H9
names: Similarity
messages: Belongs to the transglycosylase Slt family.

748449:HALHA RS03200
gene id: 748449:HALHA_RS03200
uniprot id: L0K6G9
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Membrane

748449:HALHA RS11850
gene id: 748449:HALHA_RS11850
uniprot id: L0KD66
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

748449:HALHA RS06545
gene id: 748449:HALHA_RS06545
uniprot id: L0K9S6
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

748449:HALHA RS02805
gene id: 748449:HALHA_RS02805
uniprot id: L0K5I2
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cytoplasm
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

748449:HALHA RS11070
gene id: 748449:HALHA_RS11070
uniprot id: L0KDH0
names: Similarity
messages: Belongs to the polysaccharide synthase family.

748449:HALHA RS02950
gene id: 748449:HALHA_RS02950
uniprot id: L0K883
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS07115
gene id: 748449:HALHA_RS07115
uniprot id: L0KAK3
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

748449:HALHA RS02990
gene id: 748449:HALHA_RS02990
uniprot id: L0K5L6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ScpA family.
messages: Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.
messages: Cytoplasm
messages: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.

748449:HALHA RS10145
gene id: 748449:HALHA_RS10145
uniprot id: L0KC72
names: Similarity
messages: Belongs to the CvfB family.

748449:HALHA RS04510
gene id: 748449:HALHA_RS04510
uniprot id: L0K9V3
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS04285
gene id: 748449:HALHA_RS04285
uniprot id: L0K924
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

748449:HALHA RS00695
gene id: 748449:HALHA_RS00695
uniprot id: L0K7P8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

748449:HALHA RS09165
gene id: 748449:HALHA_RS09165
uniprot id: L0K9V7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

748449:HALHA RS03870
gene id: 748449:HALHA_RS03870
uniprot id: L0K6W2
names: Similarity
messages: Belongs to the creatininase superfamily.

748449:HALHA RS12525
gene id: 748449:HALHA_RS12525
uniprot id: L0KBP6
names: Similarity
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.

748449:HALHA RS09020
gene id: 748449:HALHA_RS09020
uniprot id: L0K8Y8
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

748449:HALHA RS03050
gene id: 748449:HALHA_RS03050
uniprot id: L0K8A5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

748449:HALHA RS05220
gene id: 748449:HALHA_RS05220
uniprot id: L0K7M7
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

748449:HALHA RS00670
gene id: 748449:HALHA_RS00670
uniprot id: L0K7P5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

748449:HALHA RS09940
gene id: 748449:HALHA_RS09940
uniprot id: L0K9H1
names: Similarity
messages: Belongs to the class-I fumarase family.

748449:HALHA RS03515
gene id: 748449:HALHA_RS03515
uniprot id: L0K8J6
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

748449:HALHA RS09720
gene id: 748449:HALHA_RS09720
uniprot id: L0KBZ7
names: Function
names: Similarity
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.

748449:HALHA RS12475
gene id: 748449:HALHA_RS12475
uniprot id: L0KDH1
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

748449:HALHA RS06870
gene id: 748449:HALHA_RS06870
uniprot id: L0KAG4
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

748449:HALHA RS05120
gene id: 748449:HALHA_RS05120
uniprot id: L0KA72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

748449:HALHA RS07615
gene id: 748449:HALHA_RS07615
uniprot id: L0KBN0
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

748449:HALHA RS00930
gene id: 748449:HALHA_RS00930
uniprot id: L0K746
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

748449:HALHA RS02890
gene id: 748449:HALHA_RS02890
uniprot id: L0K6A8
names: Function
names: Similarity
messages: Belongs to the anti-sigma-factor family.
messages: Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.

748449:HALHA RS06080
gene id: 748449:HALHA_RS06080
uniprot id: L0K9X9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

748449:HALHA RS09990
gene id: 748449:HALHA_RS09990
uniprot id: L0K9I0
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the FGGY kinase family.
messages: Homotetramer and homodimer (in equilibrium).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

748449:HALHA RS09860
gene id: 748449:HALHA_RS09860
uniprot id: L0K9F6
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

748449:HALHA RS09715
gene id: 748449:HALHA_RS09715
uniprot id: L0KCT5
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

748449:HALHA RS11995
gene id: 748449:HALHA_RS11995
uniprot id: L0KE34
names: Subcellular Location Annotation
messages: Periplasm

748449:HALHA RS07870
gene id: 748449:HALHA_RS07870
uniprot id: L0KAZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

748449:HALHA RS04990
gene id: 748449:HALHA_RS04990
uniprot id: L0K6T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS08475
gene id: 748449:HALHA_RS08475
uniprot id: L0K9H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS01285
gene id: 748449:HALHA_RS01285
uniprot id: L0K6V5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

748449:HALHA RS05000
gene id: 748449:HALHA_RS05000
uniprot id: L0K9E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpxP/Spy family.
messages: Periplasm

748449:HALHA RS03440
gene id: 748449:HALHA_RS03440
uniprot id: L0K8H8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

748449:HALHA RS10725
gene id: 748449:HALHA_RS10725
uniprot id: L0KBZ4
names: Similarity
messages: Belongs to the thioredoxin family.

748449:HALHA RS06510
gene id: 748449:HALHA_RS06510
uniprot id: L0KB07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS02610
gene id: 748449:HALHA_RS02610
uniprot id: L0K8Q6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

748449:HALHA RS03755
gene id: 748449:HALHA_RS03755
uniprot id: L0K9F4
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

748449:HALHA RS08395
gene id: 748449:HALHA_RS08395
uniprot id: L0KAT2
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS03135
gene id: 748449:HALHA_RS03135
uniprot id: L0K6F4
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

748449:HALHA RS02970
gene id: 748449:HALHA_RS02970
uniprot id: L0K8Y1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

748449:HALHA RS11450
gene id: 748449:HALHA_RS11450
uniprot id: L0KCU8
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

748449:HALHA RS00945
gene id: 748449:HALHA_RS00945
uniprot id: L0K4J8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

748449:HALHA RS05170
gene id: 748449:HALHA_RS05170
uniprot id: L0KA83
names: Similarity
messages: Belongs to the dihydropyrimidine dehydrogenase family.

748449:HALHA RS13045
gene id: 748449:HALHA_RS13045
uniprot id: L0KBY3
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

748449:HALHA RS00690
gene id: 748449:HALHA_RS00690
uniprot id: L0K4F1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

748449:HALHA RS00790
gene id: 748449:HALHA_RS00790
uniprot id: L0K7R6
names: Similarity
messages: Belongs to the ClpA/ClpB family.

748449:HALHA RS00925
gene id: 748449:HALHA_RS00925
uniprot id: L0K7U5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

748449:HALHA RS01175
gene id: 748449:HALHA_RS01175
uniprot id: L0K7Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS11410
gene id: 748449:HALHA_RS11410
uniprot id: L0KB16
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

748449:HALHA RS02675
gene id: 748449:HALHA_RS02675
uniprot id: L0K671
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

748449:HALHA RS07125
gene id: 748449:HALHA_RS07125
uniprot id: L0K8R5
names: Similarity
messages: Belongs to the thioredoxin family.

748449:HALHA RS01890
gene id: 748449:HALHA_RS01890
uniprot id: L0K8D1
names: Similarity
messages: Belongs to the UPF0047 family.

748449:HALHA RS10080
gene id: 748449:HALHA_RS10080
uniprot id: L0KAC3
names: Similarity
messages: Belongs to the UPF0473 family.

748449:HALHA RS01525
gene id: 748449:HALHA_RS01525
uniprot id: L0K892
names: Similarity
messages: Belongs to the UPF0237 family.

748449:HALHA RS01015
gene id: 748449:HALHA_RS01015
uniprot id: L0K5B8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

748449:HALHA RS12130
gene id: 748449:HALHA_RS12130
uniprot id: L0KCT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

748449:HALHA RS01880
gene id: 748449:HALHA_RS01880
uniprot id: L0K5U6
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

748449:HALHA RS08525
gene id: 748449:HALHA_RS08525
uniprot id: L0K9I6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. NagD family.
messages: Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro.
messages: Divalent metal ions. Mg(2+) is the most effective.

748449:HALHA RS08130
gene id: 748449:HALHA_RS08130
uniprot id: L0K8I0
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

748449:HALHA RS05080
gene id: 748449:HALHA_RS05080
uniprot id: L0K8X3
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

748449:HALHA RS02835
gene id: 748449:HALHA_RS02835
uniprot id: L0K860
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

748449:HALHA RS04565
gene id: 748449:HALHA_RS04565
uniprot id: L0K963
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.

748449:HALHA RS01505
gene id: 748449:HALHA_RS01505
uniprot id: L0K7J9
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS07795
gene id: 748449:HALHA_RS07795
uniprot id: L0KAY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

748449:HALHA RS01770
gene id: 748449:HALHA_RS01770
uniprot id: L0K525
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS05650
gene id: 748449:HALHA_RS05650
uniprot id: L0K971
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

748449:HALHA RS00240
gene id: 748449:HALHA_RS00240
uniprot id: L0K6S4
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

748449:HALHA RS05835
gene id: 748449:HALHA_RS05835
uniprot id: L0K7Y6
names: Similarity
messages: Belongs to the four-carbon acid sugar kinase family.

748449:HALHA RS12000
gene id: 748449:HALHA_RS12000
uniprot id: L0KD93
names: Similarity
names: Subunit
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

748449:HALHA RS12865
gene id: 748449:HALHA_RS12865
uniprot id: L0KD78
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

748449:HALHA RS08155
gene id: 748449:HALHA_RS08155
uniprot id: L0K8I4
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

748449:HALHA RS12235
gene id: 748449:HALHA_RS12235
uniprot id: L0KBJ7
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS05890
gene id: 748449:HALHA_RS05890
uniprot id: L0K7Z7
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

748449:HALHA RS04775
gene id: 748449:HALHA_RS04775
uniprot id: L0K9A3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

748449:HALHA RS08120
gene id: 748449:HALHA_RS08120
uniprot id: L0KAM0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

748449:HALHA RS06760
gene id: 748449:HALHA_RS06760
uniprot id: L0KAE6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

748449:HALHA RS04915
gene id: 748449:HALHA_RS04915
uniprot id: L0K6R9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

748449:HALHA RS03710
gene id: 748449:HALHA_RS03710
uniprot id: L0K8P2
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

748449:HALHA RS09120
gene id: 748449:HALHA_RS09120
uniprot id: L0K907
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

748449:HALHA RS11635
gene id: 748449:HALHA_RS11635
uniprot id: L0KB60
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

748449:HALHA RS06925
gene id: 748449:HALHA_RS06925
uniprot id: L0KA10
names: Function
names: Similarity
names: Subunit
messages: Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization.
messages: Belongs to the HutP family.
messages: Homohexamer.

748449:HALHA RS03810
gene id: 748449:HALHA_RS03810
uniprot id: L0K878
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

748449:HALHA RS08590
gene id: 748449:HALHA_RS08590
uniprot id: L0KAX3
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS12190
gene id: 748449:HALHA_RS12190
uniprot id: L0KAQ5
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: In the native structure, TdcB is in a dimeric form, whereas in the TdcB-AMP complex, it exists in a tetrameric form (dimer of dimers).

748449:HALHA RS02385
gene id: 748449:HALHA_RS02385
uniprot id: L0K614
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

748449:HALHA RS04590
gene id: 748449:HALHA_RS04590
uniprot id: L0K968
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS10440
gene id: 748449:HALHA_RS10440
uniprot id: L0KD53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

748449:HALHA RS10055
gene id: 748449:HALHA_RS10055
uniprot id: L0KAB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

748449:HALHA RS05295
gene id: 748449:HALHA_RS05295
uniprot id: L0K9J3
names: Similarity
messages: Belongs to the UPF0251 family.

748449:HALHA RS03195
gene id: 748449:HALHA_RS03195
uniprot id: L0K7U8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.

748449:HALHA RS08540
gene id: 748449:HALHA_RS08540
uniprot id: L0KBB7
names: Similarity
messages: Belongs to the aldolase class II family. AraD/FucA subfamily.

748449:HALHA RS04960
gene id: 748449:HALHA_RS04960
uniprot id: L0K7I2
names: Similarity
messages: Belongs to the HepT RNase toxin family.

748449:HALHA RS01625
gene id: 748449:HALHA_RS01625
uniprot id: L0K504
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

748449:HALHA RS09665
gene id: 748449:HALHA_RS09665
uniprot id: L0KCS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

748449:HALHA RS12195
gene id: 748449:HALHA_RS12195
uniprot id: L0KE66
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

748449:HALHA RS03655
gene id: 748449:HALHA_RS03655
uniprot id: L0K9D1
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS03555
gene id: 748449:HALHA_RS03555
uniprot id: L0K5Z3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

748449:HALHA RS08560
gene id: 748449:HALHA_RS08560
uniprot id: L0KBC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS12165
gene id: 748449:HALHA_RS12165
uniprot id: L0KAQ0
names: Similarity
messages: Belongs to the FBPase class 2 family.

748449:HALHA RS01105
gene id: 748449:HALHA_RS01105
uniprot id: L0K787
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

748449:HALHA RS12875
gene id: 748449:HALHA_RS12875
uniprot id: L0KB21
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS12635
gene id: 748449:HALHA_RS12635
uniprot id: L0KEG5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

748449:HALHA RS10830
gene id: 748449:HALHA_RS10830
uniprot id: L0KDC0
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

748449:HALHA RS00960
gene id: 748449:HALHA_RS00960
uniprot id: L0K6N6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

748449:HALHA RS01605
gene id: 748449:HALHA_RS01605
uniprot id: L0K8A2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

748449:HALHA RS07035
gene id: 748449:HALHA_RS07035
uniprot id: L0KBB9
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

748449:HALHA RS02430
gene id: 748449:HALHA_RS02430
uniprot id: L0K7E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

748449:HALHA RS07730
gene id: 748449:HALHA_RS07730
uniprot id: L0K921
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

748449:HALHA RS09885
gene id: 748449:HALHA_RS09885
uniprot id: L0K9G1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

748449:HALHA RS01565
gene id: 748449:HALHA_RS01565
uniprot id: L0K721
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

748449:HALHA RS00440
gene id: 748449:HALHA_RS00440
uniprot id: L0K6E0
names: Similarity
messages: Belongs to the peptidase S1 family.

748449:HALHA RS09315
gene id: 748449:HALHA_RS09315
uniprot id: L0KBA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

748449:HALHA RS12300
gene id: 748449:HALHA_RS12300
uniprot id: L0KDE0
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS11945
gene id: 748449:HALHA_RS11945
uniprot id: L0KE28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

748449:HALHA RS08670
gene id: 748449:HALHA_RS08670
uniprot id: L0K9L4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

748449:HALHA RS03190
gene id: 748449:HALHA_RS03190
uniprot id: L0K8D0
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

748449:HALHA RS07985
gene id: 748449:HALHA_RS07985
uniprot id: L0KBU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

748449:HALHA RS11180
gene id: 748449:HALHA_RS11180
uniprot id: L0KC81
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

748449:HALHA RS04675
gene id: 748449:HALHA_RS04675
uniprot id: L0K6M6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

748449:HALHA RS04005
gene id: 748449:HALHA_RS04005
uniprot id: L0K6B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

748449:HALHA RS12595
gene id: 748449:HALHA_RS12595
uniprot id: L0KD24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

748449:HALHA RS01810
gene id: 748449:HALHA_RS01810
uniprot id: L0K7P3
names: Function
names: Similarity
names: Subunit
messages: Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha-keto acid in the first half-reaction.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

748449:HALHA RS10810
gene id: 748449:HALHA_RS10810
uniprot id: L0KCI2
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

748449:HALHA RS03420
gene id: 748449:HALHA_RS03420
uniprot id: L0K7Z4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

748449:HALHA RS08605
gene id: 748449:HALHA_RS08605
uniprot id: L0KC86
names: Similarity
messages: Belongs to the MscS (TC 1.A.23) family.

748449:HALHA RS12275
gene id: 748449:HALHA_RS12275
uniprot id: L0KDD6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Involved in the cleavage of the C1-C2 bond of 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy-glucuronate (5DG).

748449:HALHA RS01245
gene id: 748449:HALHA_RS01245
uniprot id: L0K4R1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS10655
gene id: 748449:HALHA_RS10655
uniprot id: L0KAL9
names: Function
messages: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.

748449:HALHA RS06865
gene id: 748449:HALHA_RS06865
uniprot id: L0KB92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

748449:HALHA RS09815
gene id: 748449:HALHA_RS09815
uniprot id: L0KCV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

748449:HALHA RS02185
gene id: 748449:HALHA_RS02185
uniprot id: L0K7B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS01955
gene id: 748449:HALHA_RS01955
uniprot id: L0K5V8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS00190
gene id: 748449:HALHA_RS00190
uniprot id: L0K7G4
names: Similarity
messages: In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
messages: In the N-terminal section; belongs to the aldehyde dehydrogenase family.

748449:HALHA RS11105
gene id: 748449:HALHA_RS11105
uniprot id: L0KC66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

748449:HALHA RS09205
gene id: 748449:HALHA_RS09205
uniprot id: L0KCK6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

748449:HALHA RS08055
gene id: 748449:HALHA_RS08055
uniprot id: L0K8G3
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

748449:HALHA RS00885
gene id: 748449:HALHA_RS00885
uniprot id: L0K752
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

748449:HALHA RS12110
gene id: 748449:HALHA_RS12110
uniprot id: L0KBH5
names: Similarity
messages: Belongs to the LacAB/RpiB family.

748449:HALHA RS08460
gene id: 748449:HALHA_RS08460
uniprot id: L0KC51
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 51 family.
messages: Homohexamer; trimer of dimers.

748449:HALHA RS12665
gene id: 748449:HALHA_RS12665
uniprot id: L0KDL2
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

748449:HALHA RS07860
gene id: 748449:HALHA_RS07860
uniprot id: L0K8C8
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

748449:HALHA RS08565
gene id: 748449:HALHA_RS08565
uniprot id: L0KAW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS07420
gene id: 748449:HALHA_RS07420
uniprot id: L0KA93
names: Similarity
messages: Belongs to the acylphosphatase family.

748449:HALHA RS11645
gene id: 748449:HALHA_RS11645
uniprot id: L0KDU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

748449:HALHA RS05755
gene id: 748449:HALHA_RS05755
uniprot id: L0K993
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane
messages: Membrane

748449:HALHA RS00135
gene id: 748449:HALHA_RS00135
uniprot id: L0K6R0
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

748449:HALHA RS09820
gene id: 748449:HALHA_RS09820
uniprot id: L0KC15
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

748449:HALHA RS11100
gene id: 748449:HALHA_RS11100
uniprot id: L0KCM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

748449:HALHA RS01260
gene id: 748449:HALHA_RS01260
uniprot id: L0K6U9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

748449:HALHA RS05990
gene id: 748449:HALHA_RS05990
uniprot id: L0K815
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

748449:HALHA RS03080
gene id: 748449:HALHA_RS03080
uniprot id: L0K7S1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

748449:HALHA RS00810
gene id: 748449:HALHA_RS00810
uniprot id: L0K4H4
names: Similarity
messages: Belongs to the ycf81 family.

748449:HALHA RS11195
gene id: 748449:HALHA_RS11195
uniprot id: L0KDJ9
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

748449:HALHA RS01875
gene id: 748449:HALHA_RS01875
uniprot id: L0K763
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

748449:HALHA RS12385
gene id: 748449:HALHA_RS12385
uniprot id: L0KBM4
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

748449:HALHA RS05625
gene id: 748449:HALHA_RS05625
uniprot id: L0K9P5
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

748449:HALHA RS06875
gene id: 748449:HALHA_RS06875
uniprot id: L0K9Z9
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS00360
gene id: 748449:HALHA_RS00360
uniprot id: L0K7J1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS07650
gene id: 748449:HALHA_RS07650
uniprot id: L0KAD2
names: Similarity
messages: Belongs to the RecJ family.

748449:HALHA RS04925
gene id: 748449:HALHA_RS04925
uniprot id: L0K9D2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

748449:HALHA RS12155
gene id: 748449:HALHA_RS12155
uniprot id: L0KCU2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS07960
gene id: 748449:HALHA_RS07960
uniprot id: L0KBU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

748449:HALHA RS11445
gene id: 748449:HALHA_RS11445
uniprot id: L0KDQ5
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

748449:HALHA RS08585
gene id: 748449:HALHA_RS08585
uniprot id: L0KBC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

748449:HALHA RS10125
gene id: 748449:HALHA_RS10125
uniprot id: L0KBP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

748449:HALHA RS05180
gene id: 748449:HALHA_RS05180
uniprot id: L0K8Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

748449:HALHA RS05965
gene id: 748449:HALHA_RS05965
uniprot id: L0K811
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS09945
gene id: 748449:HALHA_RS09945
uniprot id: L0KCX9
names: Similarity
messages: Belongs to the class-I fumarase family.

748449:HALHA RS03090
gene id: 748449:HALHA_RS03090
uniprot id: L0K5N8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

748449:HALHA RS05785
gene id: 748449:HALHA_RS05785
uniprot id: L0K7X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS11925
gene id: 748449:HALHA_RS11925
uniprot id: L0KD81
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS09295
gene id: 748449:HALHA_RS09295
uniprot id: L0K9Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

748449:HALHA RS03150
gene id: 748449:HALHA_RS03150
uniprot id: L0K6F9
names: Similarity
messages: Belongs to the DprA/Smf family.

748449:HALHA RS00965
gene id: 748449:HALHA_RS00965
uniprot id: L0K5A8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

748449:HALHA RS00680
gene id: 748449:HALHA_RS00680
uniprot id: L0K6I7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

748449:HALHA RS12510
gene id: 748449:HALHA_RS12510
uniprot id: L0KEE0
names: Similarity
messages: Belongs to the peptidase C40 family.

748449:HALHA RS02155
gene id: 748449:HALHA_RS02155
uniprot id: L0K7U6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

748449:HALHA RS08080
gene id: 748449:HALHA_RS08080
uniprot id: L0K8G9
names: Similarity
names: Subunit
messages: Belongs to the methylaspartate ammonia-lyase family.
messages: Homodimer.

748449:HALHA RS00915
gene id: 748449:HALHA_RS00915
uniprot id: L0K598
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

748449:HALHA RS09390
gene id: 748449:HALHA_RS09390
uniprot id: L0KBB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

748449:HALHA RS06495
gene id: 748449:HALHA_RS06495
uniprot id: L0K9Q2
names: Similarity
messages: Belongs to the aldose epimerase family.

748449:HALHA RS03885
gene id: 748449:HALHA_RS03885
uniprot id: L0K8T5
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

748449:HALHA RS08280
gene id: 748449:HALHA_RS08280
uniprot id: L0K9D3
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

748449:HALHA RS11250
gene id: 748449:HALHA_RS11250
uniprot id: L0KCQ4
names: Similarity
messages: Belongs to the citrate synthase family.

748449:HALHA RS12390
gene id: 748449:HALHA_RS12390
uniprot id: L0KAT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

748449:HALHA RS04740
gene id: 748449:HALHA_RS04740
uniprot id: L0K6N8
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

748449:HALHA RS07455
gene id: 748449:HALHA_RS07455
uniprot id: L0K857
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS07335
gene id: 748449:HALHA_RS07335
uniprot id: L0K839
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

748449:HALHA RS10310
gene id: 748449:HALHA_RS10310
uniprot id: L0KD33
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

748449:HALHA RS03065
gene id: 748449:HALHA_RS03065
uniprot id: L0K5N1
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

748449:HALHA RS10235
gene id: 748449:HALHA_RS10235
uniprot id: L0KC82
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

748449:HALHA RS03775
gene id: 748449:HALHA_RS03775
uniprot id: L0K645
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

748449:HALHA RS04865
gene id: 748449:HALHA_RS04865
uniprot id: L0K6Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

748449:HALHA RS09910
gene id: 748449:HALHA_RS09910
uniprot id: L0K9G6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

748449:HALHA RS05900
gene id: 748449:HALHA_RS05900
uniprot id: L0K9U4
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

748449:HALHA RS06820
gene id: 748449:HALHA_RS06820
uniprot id: L0KB85
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

748449:HALHA RS03305
gene id: 748449:HALHA_RS03305
uniprot id: L0K5T9
names: Function
names: Similarity
messages: Belongs to the GTP-binding SRP family.
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

748449:HALHA RS09030
gene id: 748449:HALHA_RS09030
uniprot id: L0KBK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

748449:HALHA RS00515
gene id: 748449:HALHA_RS00515
uniprot id: L0K6F5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

748449:HALHA RS11845
gene id: 748449:HALHA_RS11845
uniprot id: L0KE06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

748449:HALHA RS07645
gene id: 748449:HALHA_RS07645
uniprot id: L0KAV2
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

748449:HALHA RS11315
gene id: 748449:HALHA_RS11315
uniprot id: L0KA52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease PrsW family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS12250
gene id: 748449:HALHA_RS12250
uniprot id: L0KDD2
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS02055
gene id: 748449:HALHA_RS02055
uniprot id: L0K5X5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

748449:HALHA RS04230
gene id: 748449:HALHA_RS04230
uniprot id: L0K9R6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Binds 1 Fe cation per subunit.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

748449:HALHA RS12035
gene id: 748449:HALHA_RS12035
uniprot id: L0KBG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

748449:HALHA RS07700
gene id: 748449:HALHA_RS07700
uniprot id: L0KAE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

748449:HALHA RS01435
gene id: 748449:HALHA_RS01435
uniprot id: L0K753
names: Similarity
messages: Belongs to the UPF0236 family.

748449:HALHA RS06905
gene id: 748449:HALHA_RS06905
uniprot id: L0K8M4
names: Similarity
messages: Belongs to the prephenate/arogenate dehydrogenase family.

748449:HALHA RS06700
gene id: 748449:HALHA_RS06700
uniprot id: L0K7S8
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

748449:HALHA RS03175
gene id: 748449:HALHA_RS03175
uniprot id: L0K6G4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CodY family.
messages: Cytoplasm
messages: DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability. During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion.

748449:HALHA RS07925
gene id: 748449:HALHA_RS07925
uniprot id: L0KAI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

748449:HALHA RS08350
gene id: 748449:HALHA_RS08350
uniprot id: L0KAS0
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

748449:HALHA RS08545
gene id: 748449:HALHA_RS08545
uniprot id: L0KAW4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the arabinose isomerase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of L-arabinose to L-ribulose.

748449:HALHA RS09220
gene id: 748449:HALHA_RS09220
uniprot id: L0K9X1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS01220
gene id: 748449:HALHA_RS01220
uniprot id: L0K4Q5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

748449:HALHA RS10800
gene id: 748449:HALHA_RS10800
uniprot id: L0K9U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS12680
gene id: 748449:HALHA_RS12680
uniprot id: L0KAY8
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

748449:HALHA RS05600
gene id: 748449:HALHA_RS05600
uniprot id: L0KAF7
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

748449:HALHA RS04470
gene id: 748449:HALHA_RS04470
uniprot id: L0K8K9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

748449:HALHA RS00920
gene id: 748449:HALHA_RS00920
uniprot id: L0K4J4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

748449:HALHA RS13050
gene id: 748449:HALHA_RS13050
uniprot id: L0K9G4
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

748449:HALHA RS13070
gene id: 748449:HALHA_RS13070
uniprot id: L0K9S2
names: Similarity
messages: Belongs to the RecJ family.

748449:HALHA RS09775
gene id: 748449:HALHA_RS09775
uniprot id: L0KBI6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ApbE family.
messages: Cell inner membrane
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

748449:HALHA RS09670
gene id: 748449:HALHA_RS09670
uniprot id: L0KBY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

748449:HALHA RS04500
gene id: 748449:HALHA_RS04500
uniprot id: L0K798
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

748449:HALHA RS00685
gene id: 748449:HALHA_RS00685
uniprot id: L0K560
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

748449:HALHA RS01350
gene id: 748449:HALHA_RS01350
uniprot id: L0K4U8
names: Similarity
messages: Belongs to the glycosyl hydrolase 30 family.

748449:HALHA RS04310
gene id: 748449:HALHA_RS04310
uniprot id: L0K927
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS07135
gene id: 748449:HALHA_RS07135
uniprot id: L0KBD8
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS11680
gene id: 748449:HALHA_RS11680
uniprot id: L0KCI3
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS13060
gene id: 748449:HALHA_RS13060
uniprot id: L0K9H0
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

748449:HALHA RS00220
gene id: 748449:HALHA_RS00220
uniprot id: L0K4W9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

748449:HALHA RS08770
gene id: 748449:HALHA_RS08770
uniprot id: L0K9N2
names: Similarity
messages: Belongs to the GSP E family.

748449:HALHA RS12225
gene id: 748449:HALHA_RS12225
uniprot id: L0KDC9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M38 family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Carboxylation allows a single lysine to coordinate two zinc ions.
messages: Catalyzes the hydrolytic cleavage of a subset of L-isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation.
messages: Cytoplasm

748449:HALHA RS09465
gene id: 748449:HALHA_RS09465
uniprot id: L0KBD3
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS11805
gene id: 748449:HALHA_RS11805
uniprot id: L0KCM8
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS01375
gene id: 748449:HALHA_RS01375
uniprot id: L0K4W4
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

748449:HALHA RS01100
gene id: 748449:HALHA_RS01100
uniprot id: L0K7Y4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

748449:HALHA RS11475
gene id: 748449:HALHA_RS11475
uniprot id: L0KCV3
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

748449:HALHA RS08625
gene id: 748449:HALHA_RS08625
uniprot id: L0K8T4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U4 family.
messages: Cell membrane
messages: Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR.

748449:HALHA RS08505
gene id: 748449:HALHA_RS08505
uniprot id: L0K8Q8
names: Similarity
messages: Belongs to the aldose epimerase family.

748449:HALHA RS05175
gene id: 748449:HALHA_RS05175
uniprot id: L0K9H5
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

748449:HALHA RS04345
gene id: 748449:HALHA_RS04345
uniprot id: L0K777
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusB family.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

748449:HALHA RS05690
gene id: 748449:HALHA_RS05690
uniprot id: L0K9R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS10905
gene id: 748449:HALHA_RS10905
uniprot id: L0KDD7
names: Subcellular Location Annotation
messages: Cytoplasm

748449:HALHA RS06190
gene id: 748449:HALHA_RS06190
uniprot id: L0KA01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
messages: Homooctamer.

748449:HALHA RS05875
gene id: 748449:HALHA_RS05875
uniprot id: L0KAL8
names: Similarity
names: Subunit
messages: Belongs to the PdxA family. PdxA2 subfamily.
messages: Homodimer.

748449:HALHA RS04725
gene id: 748449:HALHA_RS04725
uniprot id: L0K9Z3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

748449:HALHA RS07930
gene id: 748449:HALHA_RS07930
uniprot id: L0K960
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
messages: Cytoplasm

748449:HALHA RS04825
gene id: 748449:HALHA_RS04825
uniprot id: L0K9B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

748449:HALHA RS01180
gene id: 748449:HALHA_RS01180
uniprot id: L0K7A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS12125
gene id: 748449:HALHA_RS12125
uniprot id: L0KDB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Probably functions as a manganese efflux pump.

748449:HALHA RS06685
gene id: 748449:HALHA_RS06685
uniprot id: L0KAD3
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS04105
gene id: 748449:HALHA_RS04105
uniprot id: L0K738
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PstS family.
messages: Cell membrane
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

748449:HALHA RS03375
gene id: 748449:HALHA_RS03375
uniprot id: L0K6K7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

748449:HALHA RS04540
gene id: 748449:HALHA_RS04540
uniprot id: L0K958
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.

748449:HALHA RS12440
gene id: 748449:HALHA_RS12440
uniprot id: L0KAU7
names: Similarity
messages: Belongs to the sigma-54 factor family.

748449:HALHA RS08515
gene id: 748449:HALHA_RS08515
uniprot id: L0KBB3
names: Similarity
messages: Belongs to the transketolase family.

748449:HALHA RS12485
gene id: 748449:HALHA_RS12485
uniprot id: L0KBN9
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

748449:HALHA RS03230
gene id: 748449:HALHA_RS03230
uniprot id: L0K5S1
names: Similarity
messages: Belongs to the FlgD family.

748449:HALHA RS05045
gene id: 748449:HALHA_RS05045
uniprot id: L0KA57
names: Similarity
messages: In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
messages: In the N-terminal section; belongs to the aldehyde dehydrogenase family.

748449:HALHA RS03715
gene id: 748449:HALHA_RS03715
uniprot id: L0K855
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.

748449:HALHA RS06695
gene id: 748449:HALHA_RS06695
uniprot id: L0K8I7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

748449:HALHA RS09455
gene id: 748449:HALHA_RS09455
uniprot id: L0KCP6
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

748449:HALHA RS11370
gene id: 748449:HALHA_RS11370
uniprot id: L0KDN7
names: Similarity
messages: Belongs to the transketolase family.

748449:HALHA RS11380
gene id: 748449:HALHA_RS11380
uniprot id: L0KCC2
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

748449:HALHA RS04315
gene id: 748449:HALHA_RS04315
uniprot id: L0K8I6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LPG synthase family.
messages: Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.
messages: Cell membrane
messages: Membrane

748449:HALHA RS11430
gene id: 748449:HALHA_RS11430
uniprot id: L0KCD3
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS05620
gene id: 748449:HALHA_RS05620
uniprot id: L0KAG2
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

748449:HALHA RS10305
gene id: 748449:HALHA_RS10305
uniprot id: L0K9L8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS07600
gene id: 748449:HALHA_RS07600
uniprot id: L0KAC1
names: Cofactor
messages: Binds 2 magnesium ions per subunit.

748449:HALHA RS08950
gene id: 748449:HALHA_RS08950
uniprot id: L0KCD6
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS07765
gene id: 748449:HALHA_RS07765
uniprot id: L0KBQ7
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

748449:HALHA RS08135
gene id: 748449:HALHA_RS08135
uniprot id: L0KBX7
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

748449:HALHA RS03630
gene id: 748449:HALHA_RS03630
uniprot id: L0K9C5
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS00550
gene id: 748449:HALHA_RS00550
uniprot id: L0K4C2
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

748449:HALHA RS11885
gene id: 748449:HALHA_RS11885
uniprot id: L0KBD4
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

748449:HALHA RS12425
gene id: 748449:HALHA_RS12425
uniprot id: L0KDG2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

748449:HALHA RS09810
gene id: 748449:HALHA_RS09810
uniprot id: L0K9E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

748449:HALHA RS10320
gene id: 748449:HALHA_RS10320
uniprot id: L0KBR9
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

748449:HALHA RS10070
gene id: 748449:HALHA_RS10070
uniprot id: L0KC58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

748449:HALHA RS09000
gene id: 748449:HALHA_RS09000
uniprot id: L0KCE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS01900
gene id: 748449:HALHA_RS01900
uniprot id: L0K766
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

748449:HALHA RS10135
gene id: 748449:HALHA_RS10135
uniprot id: L0K9J9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

748449:HALHA RS11030
gene id: 748449:HALHA_RS11030
uniprot id: L0KC50
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

748449:HALHA RS09015
gene id: 748449:HALHA_RS09015
uniprot id: L0K9R2
names: Cofactor
messages: Binds 2 magnesium ions per subunit.

748449:HALHA RS06550
gene id: 748449:HALHA_RS06550
uniprot id: L0K8E2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS05735
gene id: 748449:HALHA_RS05735
uniprot id: L0K753
names: Similarity
messages: Belongs to the UPF0236 family.

748449:HALHA RS11695
gene id: 748449:HALHA_RS11695
uniprot id: L0KDV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

748449:HALHA RS01025
gene id: 748449:HALHA_RS01025
uniprot id: L0K7W7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

748449:HALHA RS09405
gene id: 748449:HALHA_RS09405
uniprot id: L0KCN9
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

748449:HALHA RS09900
gene id: 748449:HALHA_RS09900
uniprot id: L0KBK8
names: Similarity
messages: Belongs to the peptidase S16 family.

748449:HALHA RS12830
gene id: 748449:HALHA_RS12830
uniprot id: L0KEK1
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

748449:HALHA RS00675
gene id: 748449:HALHA_RS00675
uniprot id: L0K6Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

748449:HALHA RS05670
gene id: 748449:HALHA_RS05670
uniprot id: L0K9Q4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

748449:HALHA RS10200
gene id: 748449:HALHA_RS10200
uniprot id: L0KD16
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

748449:HALHA RS10065
gene id: 748449:HALHA_RS10065
uniprot id: L0KCZ8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Catalyzes the methylation of 5-hydroxyuridine (ho5U) to form 5-methoxyuridine (mo5U) at position 34 in tRNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS09930
gene id: 748449:HALHA_RS09930
uniprot id: L0KBL3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

748449:HALHA RS12445
gene id: 748449:HALHA_RS12445
uniprot id: L0KEC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

748449:HALHA RS03415
gene id: 748449:HALHA_RS03415
uniprot id: L0K8H3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

748449:HALHA RS00185
gene id: 748449:HALHA_RS00185
uniprot id: L0K446
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

748449:HALHA RS12150
gene id: 748449:HALHA_RS12150
uniprot id: L0KDB5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

748449:HALHA RS07205
gene id: 748449:HALHA_RS07205
uniprot id: L0KBF1
names: Similarity
messages: Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.

748449:HALHA RS12795
gene id: 748449:HALHA_RS12795
uniprot id: L0KBV0
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

748449:HALHA RS11145
gene id: 748449:HALHA_RS11145
uniprot id: L0KA11
names: Similarity
messages: Belongs to the FlgM family.

748449:HALHA RS12400
gene id: 748449:HALHA_RS12400
uniprot id: L0KDF9
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS12535
gene id: 748449:HALHA_RS12535
uniprot id: L0KEE6
names: Similarity
messages: Belongs to the GerABKC lipoprotein family.

748449:HALHA RS12575
gene id: 748449:HALHA_RS12575
uniprot id: L0KBQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Membrane

748449:HALHA RS09395
gene id: 748449:HALHA_RS09395
uniprot id: L0KA04
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

748449:HALHA RS00400
gene id: 748449:HALHA_RS00400
uniprot id: L0K506
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

748449:HALHA RS12170
gene id: 748449:HALHA_RS12170
uniprot id: L0KE61
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

748449:HALHA RS00560
gene id: 748449:HALHA_RS00560
uniprot id: L0K6Y0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

748449:HALHA RS06810
gene id: 748449:HALHA_RS06810
uniprot id: L0K8K5
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

748449:HALHA RS10025
gene id: 748449:HALHA_RS10025
uniprot id: L0KBM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS05710
gene id: 748449:HALHA_RS05710
uniprot id: L0KAI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CotF family.
messages: Spore coat

748449:HALHA RS12075
gene id: 748449:HALHA_RS12075
uniprot id: L0KDA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

748449:HALHA RS02995
gene id: 748449:HALHA_RS02995
uniprot id: L0K8Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ScpB family.
messages: Cytoplasm
messages: Homodimer. Homodimerization may be required to stabilize the binding of ScpA to the Smc head domains. Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.
messages: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.

748449:HALHA RS12765
gene id: 748449:HALHA_RS12765
uniprot id: L0KD59
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

748449:HALHA RS09925
gene id: 748449:HALHA_RS09925
uniprot id: L0KC35
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

748449:HALHA RS12950
gene id: 748449:HALHA_RS12950
uniprot id: L0K8D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS02930
gene id: 748449:HALHA_RS02930
uniprot id: L0K7P0
names: Similarity
messages: Belongs to the GerABKA family.

748449:HALHA RS12230
gene id: 748449:HALHA_RS12230
uniprot id: L0KCV7
names: Similarity
messages: Belongs to the glutamine synthetase family.

748449:HALHA RS12025
gene id: 748449:HALHA_RS12025
uniprot id: L0KD97
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS04545
gene id: 748449:HALHA_RS04545
uniprot id: L0K8M2
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS00465
gene id: 748449:HALHA_RS00465
uniprot id: L0K6E4
names: Function
names: Similarity
messages: Belongs to the peptidase S51 family.
messages: Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.

748449:HALHA RS06125
gene id: 748449:HALHA_RS06125
uniprot id: L0K842
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

748449:HALHA RS00295
gene id: 748449:HALHA_RS00295
uniprot id: L0K6B5
names: Similarity
messages: Belongs to the thymidylate kinase family.

748449:HALHA RS00380
gene id: 748449:HALHA_RS00380
uniprot id: L0K487
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS01115
gene id: 748449:HALHA_RS01115
uniprot id: L0K5D9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).
messages: Membrane

748449:HALHA RS03295
gene id: 748449:HALHA_RS03295
uniprot id: U3GM94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

748449:HALHA RS02785
gene id: 748449:HALHA_RS02785
uniprot id: L0K8U2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS03395
gene id: 748449:HALHA_RS03395
uniprot id: L0K7Z0
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS09915
gene id: 748449:HALHA_RS09915
uniprot id: L0KCX5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

748449:HALHA RS03475
gene id: 748449:HALHA_RS03475
uniprot id: L0K6M7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

748449:HALHA RS08690
gene id: 748449:HALHA_RS08690
uniprot id: L0KAZ7
names: Similarity
messages: Belongs to the transpeptidase family.

748449:HALHA RS05560
gene id: 748449:HALHA_RS05560
uniprot id: L0K949
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.
messages: Homotetramer.

748449:HALHA RS03240
gene id: 748449:HALHA_RS03240
uniprot id: L0K8D8
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

748449:HALHA RS01470
gene id: 748449:HALHA_RS01470
uniprot id: L0K4Y0
names: Function
names: Similarity
messages: Belongs to the PemK/MazF family.
messages: Toxic component of a type II toxin-antitoxin (TA) system.

748449:HALHA RS00580
gene id: 748449:HALHA_RS00580
uniprot id: L0K7N2
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

748449:HALHA RS07970
gene id: 748449:HALHA_RS07970
uniprot id: L0KAJ0
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS06605
gene id: 748449:HALHA_RS06605
uniprot id: L0K7R0
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

748449:HALHA RS06635
gene id: 748449:HALHA_RS06635
uniprot id: L0KAC4
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

748449:HALHA RS11080
gene id: 748449:HALHA_RS11080
uniprot id: U3GL14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

748449:HALHA RS10970
gene id: 748449:HALHA_RS10970
uniprot id: L0KAS9
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

748449:HALHA RS03770
gene id: 748449:HALHA_RS03770
uniprot id: L0K6U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS08340
gene id: 748449:HALHA_RS08340
uniprot id: L0KC22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

748449:HALHA RS02230
gene id: 748449:HALHA_RS02230
uniprot id: L0K8I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS02695
gene id: 748449:HALHA_RS02695
uniprot id: L0K7J7
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

748449:HALHA RS02220
gene id: 748449:HALHA_RS02220
uniprot id: L0K5Z9
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS11830
gene id: 748449:HALHA_RS11830
uniprot id: L0KCN3
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

748449:HALHA RS08105
gene id: 748449:HALHA_RS08105
uniprot id: L0K8H5
names: Similarity
messages: Belongs to the glutamate synthase family.

748449:HALHA RS01295
gene id: 748449:HALHA_RS01295
uniprot id: L0K4S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS08385
gene id: 748449:HALHA_RS08385
uniprot id: L0KC33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

748449:HALHA RS01095
gene id: 748449:HALHA_RS01095
uniprot id: L0K4M8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

748449:HALHA RS04135
gene id: 748449:HALHA_RS04135
uniprot id: L0K6E5
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS01760
gene id: 748449:HALHA_RS01760
uniprot id: L0K750
names: Similarity
messages: Belongs to the UPF0236 family.

748449:HALHA RS04875
gene id: 748449:HALHA_RS04875
uniprot id: L0K9C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

748449:HALHA RS04495
gene id: 748449:HALHA_RS04495
uniprot id: L0K8L3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

748449:HALHA RS12100
gene id: 748449:HALHA_RS12100
uniprot id: L0KDA7
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

748449:HALHA RS08240
gene id: 748449:HALHA_RS08240
uniprot id: L0KC00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

748449:HALHA RS06340
gene id: 748449:HALHA_RS06340
uniprot id: L0KA34
names: Similarity
messages: Belongs to the HypE family.

748449:HALHA RS00715
gene id: 748449:HALHA_RS00715
uniprot id: L0K4F8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS12330
gene id: 748449:HALHA_RS12330
uniprot id: L0KCX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS07800
gene id: 748449:HALHA_RS07800
uniprot id: L0KAF8
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

748449:HALHA RS05510
gene id: 748449:HALHA_RS05510
uniprot id: L0K9M5
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

748449:HALHA RS02620
gene id: 748449:HALHA_RS02620
uniprot id: L0K7I1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

748449:HALHA RS04685
gene id: 748449:HALHA_RS04685
uniprot id: L0K986
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

748449:HALHA RS04320
gene id: 748449:HALHA_RS04320
uniprot id: L0K773
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

748449:HALHA RS00530
gene id: 748449:HALHA_RS00530
uniprot id: L0K7M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

748449:HALHA RS08580
gene id: 748449:HALHA_RS08580
uniprot id: L0KC79
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

748449:HALHA RS06915
gene id: 748449:HALHA_RS06915
uniprot id: L0KB99
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

748449:HALHA RS05630
gene id: 748449:HALHA_RS05630
uniprot id: L0K965
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS01060
gene id: 748449:HALHA_RS01060
uniprot id: L0K6Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

748449:HALHA RS02495
gene id: 748449:HALHA_RS02495
uniprot id: L0K8N0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

748449:HALHA RS06965
gene id: 748449:HALHA_RS06965
uniprot id: L0KAH9
names: Similarity
messages: Belongs to the fabD family.

748449:HALHA RS05775
gene id: 748449:HALHA_RS05775
uniprot id: L0K9S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS05410
gene id: 748449:HALHA_RS05410
uniprot id: L0K926
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

748449:HALHA RS07885
gene id: 748449:HALHA_RS07885
uniprot id: L0K8D2
names: Similarity
messages: Belongs to the CinA family.

748449:HALHA RS11325
gene id: 748449:HALHA_RS11325
uniprot id: L0KCS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

748449:HALHA RS07990
gene id: 748449:HALHA_RS07990
uniprot id: L0KB17
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

748449:HALHA RS00935
gene id: 748449:HALHA_RS00935
uniprot id: L0K6N3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

748449:HALHA RS03835
gene id: 748449:HALHA_RS03835
uniprot id: L0K884
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

748449:HALHA RS01300
gene id: 748449:HALHA_RS01300
uniprot id: L0K828
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS10035
gene id: 748449:HALHA_RS10035
uniprot id: L0K9I3
names: Similarity
messages: Belongs to the ABC transporter superfamily.

748449:HALHA RS03165
gene id: 748449:HALHA_RS03165
uniprot id: L0K8C6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

748449:HALHA RS07345
gene id: 748449:HALHA_RS07345
uniprot id: L0KAP3
names: Similarity
messages: Belongs to the peptidase S16 family.

748449:HALHA RS08405
gene id: 748449:HALHA_RS08405
uniprot id: L0K8N8
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS00795
gene id: 748449:HALHA_RS00795
uniprot id: L0K715
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

748449:HALHA RS00140
gene id: 748449:HALHA_RS00140
uniprot id: L0K692
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS07100
gene id: 748449:HALHA_RS07100
uniprot id: L0K8R0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

748449:HALHA RS05310
gene id: 748449:HALHA_RS05310
uniprot id: L0K7N9
names: Subcellular Location Annotation
messages: Cytoplasm

748449:HALHA RS02070
gene id: 748449:HALHA_RS02070
uniprot id: L0K7T0
names: Subcellular Location Annotation
messages: Cytoplasm

748449:HALHA RS10315
gene id: 748449:HALHA_RS10315
uniprot id: L0KC96
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

748449:HALHA RS09350
gene id: 748449:HALHA_RS09350
uniprot id: L0K974
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

748449:HALHA RS07690
gene id: 748449:HALHA_RS07690
uniprot id: L0KBP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

748449:HALHA RS03660
gene id: 748449:HALHA_RS03660
uniprot id: L0K8N1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

748449:HALHA RS09320
gene id: 748449:HALHA_RS09320
uniprot id: L0K9Z0
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

748449:HALHA RS05970
gene id: 748449:HALHA_RS05970
uniprot id: L0K7A0
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

748449:HALHA RS04595
gene id: 748449:HALHA_RS04595
uniprot id: L0K8M9
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS09875
gene id: 748449:HALHA_RS09875
uniprot id: L0KBK5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

748449:HALHA RS11400
gene id: 748449:HALHA_RS11400
uniprot id: L0KCT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

748449:HALHA RS01225
gene id: 748449:HALHA_RS01225
uniprot id: L0K812
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

748449:HALHA RS01600
gene id: 748449:HALHA_RS01600
uniprot id: L0K500
names: Similarity
messages: Belongs to the EamA transporter family.

748449:HALHA RS00575
gene id: 748449:HALHA_RS00575
uniprot id: L0K4C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS02795
gene id: 748449:HALHA_RS02795
uniprot id: L0K7L5
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

748449:HALHA RS03700
gene id: 748449:HALHA_RS03700
uniprot id: L0K630
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

748449:HALHA RS13010
gene id: 748449:HALHA_RS13010
uniprot id: L0K982
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

748449:HALHA RS08480
gene id: 748449:HALHA_RS08480
uniprot id: L0K8Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS03290
gene id: 748449:HALHA_RS03290
uniprot id: U3GLG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

748449:HALHA RS12055
gene id: 748449:HALHA_RS12055
uniprot id: L0KCS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

748449:HALHA RS01425
gene id: 748449:HALHA_RS01425
uniprot id: L0K4X0
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

748449:HALHA RS12520
gene id: 748449:HALHA_RS12520
uniprot id: L0KD10
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

748449:HALHA RS02550
gene id: 748449:HALHA_RS02550
uniprot id: L0K647
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS09995
gene id: 748449:HALHA_RS09995
uniprot id: L0KCY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

748449:HALHA RS07000
gene id: 748449:HALHA_RS07000
uniprot id: L0K8P5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

748449:HALHA RS09240
gene id: 748449:HALHA_RS09240
uniprot id: L0KB95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0053 family.
messages: Membrane

748449:HALHA RS00470
gene id: 748449:HALHA_RS00470
uniprot id: L0K518
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer).
messages: Homodimer.
messages: In the C-terminal section; belongs to the MurCDEF family.

748449:HALHA RS00010
gene id: 748449:HALHA_RS00010
uniprot id: L0K679
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

748449:HALHA RS04165
gene id: 748449:HALHA_RS04165
uniprot id: L0K8G1
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

748449:HALHA RS12415
gene id: 748449:HALHA_RS12415
uniprot id: L0KAU2
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.
messages: Homotetramer.

748449:HALHA RS05595
gene id: 748449:HALHA_RS05595
uniprot id: L0K722
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

748449:HALHA RS12205
gene id: 748449:HALHA_RS12205
uniprot id: L0KCV1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

748449:HALHA RS12245
gene id: 748449:HALHA_RS12245
uniprot id: L0KE83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS10735
gene id: 748449:HALHA_RS10735
uniprot id: L0K9T6
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS01045
gene id: 748449:HALHA_RS01045
uniprot id: L0K4L6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

748449:HALHA RS00905
gene id: 748449:HALHA_RS00905
uniprot id: L0K739
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

748449:HALHA RS06565
gene id: 748449:HALHA_RS06565
uniprot id: L0KA99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.
messages: Cytoplasm

748449:HALHA RS07790
gene id: 748449:HALHA_RS07790
uniprot id: L0KBR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

748449:HALHA RS03130
gene id: 748449:HALHA_RS03130
uniprot id: L0K7T3
names: Similarity
messages: Belongs to the UPF0102 family.

748449:HALHA RS11375
gene id: 748449:HALHA_RS11375
uniprot id: L0KCT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

748449:HALHA RS09105
gene id: 748449:HALHA_RS09105
uniprot id: L0KBM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

748449:HALHA RS06625
gene id: 748449:HALHA_RS06625
uniprot id: L0K7R4
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

748449:HALHA RS08085
gene id: 748449:HALHA_RS08085
uniprot id: L0KBW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methylaspartate mutase GlmE subunit family.
messages: Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).
messages: Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.

748449:HALHA RS00910
gene id: 748449:HALHA_RS00910
uniprot id: L0K6M9
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

748449:HALHA RS06445
gene id: 748449:HALHA_RS06445
uniprot id: L0K9P1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

748449:HALHA RS12670
gene id: 748449:HALHA_RS12670
uniprot id: L0KD36
names: Similarity
messages: Belongs to the SAICAR synthetase family.

748449:HALHA RS00235
gene id: 748449:HALHA_RS00235
uniprot id: L0K7G8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

748449:HALHA RS08910
gene id: 748449:HALHA_RS08910
uniprot id: L0KB18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

748449:HALHA RS07430
gene id: 748449:HALHA_RS07430
uniprot id: L0K853
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecU family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation.

748449:HALHA RS09770
gene id: 748449:HALHA_RS09770
uniprot id: L0KC07
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

748449:HALHA RS04560
gene id: 748449:HALHA_RS04560
uniprot id: L0K9W0
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

748449:HALHA RS12360
gene id: 748449:HALHA_RS12360
uniprot id: L0KBL9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS06185
gene id: 748449:HALHA_RS06185
uniprot id: L0KAT5
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

748449:HALHA RS01440
gene id: 748449:HALHA_RS01440
uniprot id: L0K6Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0073 (Hly-III) family.
messages: Membrane

748449:HALHA RS07030
gene id: 748449:HALHA_RS07030
uniprot id: L0K7Y7
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.

748449:HALHA RS03325
gene id: 748449:HALHA_RS03325
uniprot id: L0K6J5
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

748449:HALHA RS00230
gene id: 748449:HALHA_RS00230
uniprot id: L0K451
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

748449:HALHA RS04630
gene id: 748449:HALHA_RS04630
uniprot id: L0K6L9
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS02465
gene id: 748449:HALHA_RS02465
uniprot id: L0K5C1
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

748449:HALHA RS12135
gene id: 748449:HALHA_RS12135
uniprot id: L0KBI0
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

748449:HALHA RS09250
gene id: 748449:HALHA_RS09250
uniprot id: L0K956
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

748449:HALHA RS04735
gene id: 748449:HALHA_RS04735
uniprot id: L0K8R1
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

748449:HALHA RS00245
gene id: 748449:HALHA_RS00245
uniprot id: L0K6A6
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

748449:HALHA RS03875
gene id: 748449:HALHA_RS03875
uniprot id: L0K669
names: Similarity
messages: Belongs to the UPF0309 family.

748449:HALHA RS11575
gene id: 748449:HALHA_RS11575
uniprot id: L0KCY0
names: Similarity
messages: Belongs to the UDPGP type 2 family.

748449:HALHA RS08415
gene id: 748449:HALHA_RS08415
uniprot id: L0KB93
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

748449:HALHA RS03270
gene id: 748449:HALHA_RS03270
uniprot id: L0K7W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

748449:HALHA RS10215
gene id: 748449:HALHA_RS10215
uniprot id: L0KAD9
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS10280
gene id: 748449:HALHA_RS10280
uniprot id: L0K9L6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

748449:HALHA RS09245
gene id: 748449:HALHA_RS09245
uniprot id: L0K9X6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

748449:HALHA RS04100
gene id: 748449:HALHA_RS04100
uniprot id: L0K8F3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PstS family.
messages: Cell membrane
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

748449:HALHA RS07625
gene id: 748449:HALHA_RS07625
uniprot id: L0KAC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS12960
gene id: 748449:HALHA_RS12960
uniprot id: L0K8U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LPG synthase family.
messages: Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.
messages: Cell membrane
messages: Membrane

748449:HALHA RS01500
gene id: 748449:HALHA_RS01500
uniprot id: L0K887
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

748449:HALHA RS12880
gene id: 748449:HALHA_RS12880
uniprot id: L0KEK8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpA which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpB RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpA.
messages: Has an N-terminal Jag-N domain and 2 RNA-binding domains (KH and R3H).

748449:HALHA RS09650
gene id: 748449:HALHA_RS09650
uniprot id: L0KBG4
names: Similarity
messages: Belongs to the Lgt family.

748449:HALHA RS09740
gene id: 748449:HALHA_RS09740
uniprot id: L0KCU0
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

748449:HALHA RS04860
gene id: 748449:HALHA_RS04860
uniprot id: L0K7G5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

748449:HALHA RS03815
gene id: 748449:HALHA_RS03815
uniprot id: L0K6V2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Binds 1 Fe(2+) ion per subunit. The iron ion 2 is coordinated via four histidines and one cysteine residue.
messages: Binds 1 Fe(3+) ion per subunit. The iron ion 1 is coordinated via 4 cysteine residues.
messages: Catalyzes the one-electron reduction of superoxide anion radical to hydrogen peroxide at a nonheme ferrous iron center. Plays a fundamental role in case of oxidative stress via its superoxide detoxification activity.

748449:HALHA RS08630
gene id: 748449:HALHA_RS08630
uniprot id: L0KC92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

748449:HALHA RS02680
gene id: 748449:HALHA_RS02680
uniprot id: L0K5G1
names: Similarity
messages: Belongs to the asp23 family.

748449:HALHA RS03560
gene id: 748449:HALHA_RS03560
uniprot id: L0K9A7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

748449:HALHA RS04920
gene id: 748449:HALHA_RS04920
uniprot id: L0KA32
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

748449:HALHA RS04505
gene id: 748449:HALHA_RS04505
uniprot id: L0K6J8
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

748449:HALHA RS00830
gene id: 748449:HALHA_RS00830
uniprot id: L0K584
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

748449:HALHA RS04075
gene id: 748449:HALHA_RS04075
uniprot id: L0K8E9
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

748449:HALHA RS09735
gene id: 748449:HALHA_RS09735
uniprot id: L0K9D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

748449:HALHA RS08600
gene id: 748449:HALHA_RS08600
uniprot id: L0K8T0
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS03360
gene id: 748449:HALHA_RS03360
uniprot id: L0K962
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

748449:HALHA RS01445
gene id: 748449:HALHA_RS01445
uniprot id: L0K5M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

748449:HALHA RS03690
gene id: 748449:HALHA_RS03690
uniprot id: L0K8N7
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS01065
gene id: 748449:HALHA_RS01065
uniprot id: L0K5C9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

748449:HALHA RS08125
gene id: 748449:HALHA_RS08125
uniprot id: L0K9A0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MetA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

748449:HALHA RS01020
gene id: 748449:HALHA_RS01020
uniprot id: L0K4L2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

748449:HALHA RS05585
gene id: 748449:HALHA_RS05585
uniprot id: L0K954
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

748449:HALHA RS10150
gene id: 748449:HALHA_RS10150
uniprot id: L0KBP5
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS02775
gene id: 748449:HALHA_RS02775
uniprot id: L0K687
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

748449:HALHA RS10385
gene id: 748449:HALHA_RS10385
uniprot id: L0K9N0
names: Function
names: Similarity
names: Subunit
messages: Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization.
messages: Belongs to the HutP family.
messages: Homohexamer.

748449:HALHA RS05940
gene id: 748449:HALHA_RS05940
uniprot id: L0K796
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

748449:HALHA RS08970
gene id: 748449:HALHA_RS08970
uniprot id: L0K8X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS12890
gene id: 748449:HALHA_RS12890
uniprot id: L0KD83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

748449:HALHA RS03950
gene id: 748449:HALHA_RS03950
uniprot id: L0K6A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS03830
gene id: 748449:HALHA_RS03830
uniprot id: L0K8S2
names: Similarity
messages: Belongs to the ThiD family.

748449:HALHA RS01995
gene id: 748449:HALHA_RS01995
uniprot id: L0K7R5
names: Similarity
messages: Belongs to the pyruvate kinase family.
messages: In the C-terminal section; belongs to the PEP-utilizing enzyme family.

748449:HALHA RS12120
gene id: 748449:HALHA_RS12120
uniprot id: L0KE51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Probably functions as a manganese efflux pump.

748449:HALHA RS02720
gene id: 748449:HALHA_RS02720
uniprot id: L0K7K1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

748449:HALHA RS10675
gene id: 748449:HALHA_RS10675
uniprot id: L0KBY4
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

748449:HALHA RS01420
gene id: 748449:HALHA_RS01420
uniprot id: L0K5M5
names: Similarity
messages: Belongs to the mannitol dehydrogenase family.

748449:HALHA RS09060
gene id: 748449:HALHA_RS09060
uniprot id: L0KB44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

748449:HALHA RS11585
gene id: 748449:HALHA_RS11585
uniprot id: L0KB48
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

748449:HALHA RS01315
gene id: 748449:HALHA_RS01315
uniprot id: L0K5I1
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

748449:HALHA RS12295
gene id: 748449:HALHA_RS12295
uniprot id: L0KE92
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D-gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP).

748449:HALHA RS02975
gene id: 748449:HALHA_RS02975
uniprot id: L0K888
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

748449:HALHA RS01035
gene id: 748449:HALHA_RS01035
uniprot id: L0K6Q1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

748449:HALHA RS07440
gene id: 748449:HALHA_RS07440
uniprot id: L0KAR1
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS07090
gene id: 748449:HALHA_RS07090
uniprot id: L0KAK0
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS06170
gene id: 748449:HALHA_RS06170
uniprot id: L0K9I5
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

748449:HALHA RS00395
gene id: 748449:HALHA_RS00395
uniprot id: L0K6D5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease M5 family.
messages: Cytoplasm
messages: Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step.

748449:HALHA RS01160
gene id: 748449:HALHA_RS01160
uniprot id: L0K6S7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS01070
gene id: 748449:HALHA_RS01070
uniprot id: L0K4M2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

748449:HALHA RS06115
gene id: 748449:HALHA_RS06115
uniprot id: L0K9Y4
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
messages: May be involved in the biosynthesis of molybdopterin.

748449:HALHA RS09895
gene id: 748449:HALHA_RS09895
uniprot id: L0KC30
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

748449:HALHA RS03115
gene id: 748449:HALHA_RS03115
uniprot id: L0K5P3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

748449:HALHA RS08145
gene id: 748449:HALHA_RS08145
uniprot id: L0KAM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

748449:HALHA RS07980
gene id: 748449:HALHA_RS07980
uniprot id: L0K8F0
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

748449:HALHA RS05700
gene id: 748449:HALHA_RS05700
uniprot id: L0K750
names: Similarity
messages: Belongs to the UPF0236 family.

748449:HALHA RS12675
gene id: 748449:HALHA_RS12675
uniprot id: L0KBS7
names: Function
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

748449:HALHA RS12420
gene id: 748449:HALHA_RS12420
uniprot id: L0KEC3
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

748449:HALHA RS04140
gene id: 748449:HALHA_RS04140
uniprot id: L0K9Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

748449:HALHA RS04855
gene id: 748449:HALHA_RS04855
uniprot id: L0K8T3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

748449:HALHA RS05825
gene id: 748449:HALHA_RS05825
uniprot id: L0K9T3
names: Similarity
messages: Belongs to the UxaA family.

748449:HALHA RS11210
gene id: 748449:HALHA_RS11210
uniprot id: L0KAX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

748449:HALHA RS02830
gene id: 748449:HALHA_RS02830
uniprot id: L0K5I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

748449:HALHA RS08045
gene id: 748449:HALHA_RS08045
uniprot id: L0KAK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

748449:HALHA RS03070
gene id: 748449:HALHA_RS03070
uniprot id: L0K8Z9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

748449:HALHA RS05485
gene id: 748449:HALHA_RS05485
uniprot id: L0K936
names: Similarity
messages: Belongs to the Rpn/YhgA-like nuclease family.

748449:HALHA RS02480
gene id: 748449:HALHA_RS02480
uniprot id: L0K7F6
names: Similarity
messages: Belongs to the UPF0751 family.

748449:HALHA RS11270
gene id: 748449:HALHA_RS11270
uniprot id: L0KDL7
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

748449:HALHA RS04710
gene id: 748449:HALHA_RS04710
uniprot id: L0K8Q5
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

748449:HALHA RS02540
gene id: 748449:HALHA_RS02540
uniprot id: L0K8N9
names: Similarity
messages: Belongs to the threonine aldolase family.

748449:HALHA RS10765
gene id: 748449:HALHA_RS10765
uniprot id: L0KAN8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

748449:HALHA RS01655
gene id: 748449:HALHA_RS01655
uniprot id: L0K509
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS05095
gene id: 748449:HALHA_RS05095
uniprot id: L0KA68
names: Similarity
messages: Belongs to the disproportionating enzyme family.

748449:HALHA RS05915
gene id: 748449:HALHA_RS05915
uniprot id: L0K790
names: Similarity
messages: Belongs to the asp23 family.

748449:HALHA RS03595
gene id: 748449:HALHA_RS03595
uniprot id: L0K6Q2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

748449:HALHA RS13600
gene id: 748449:HALHA_RS13600
uniprot id: L0K5Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

748449:HALHA RS08150
gene id: 748449:HALHA_RS08150
uniprot id: L0K9A6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

748449:HALHA RS01005
gene id: 748449:HALHA_RS01005
uniprot id: L0K762
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

748449:HALHA RS02065
gene id: 748449:HALHA_RS02065
uniprot id: L0K8G0
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

748449:HALHA RS02145
gene id: 748449:HALHA_RS02145
uniprot id: L0K583
names: Similarity
messages: Belongs to the peptidase U62 family.

748449:HALHA RS02050
gene id: 748449:HALHA_RS02050
uniprot id: L0K793
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

748449:HALHA RS10395
gene id: 748449:HALHA_RS10395
uniprot id: L0KCA9
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

748449:HALHA RS06135
gene id: 748449:HALHA_RS06135
uniprot id: L0KAS3
names: Function
names: Similarity
messages: Belongs to the MoaB/Mog family.
messages: May be involved in the biosynthesis of molybdopterin.

748449:HALHA RS10285
gene id: 748449:HALHA_RS10285
uniprot id: L0KD29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

748449:HALHA RS12650
gene id: 748449:HALHA_RS12650
uniprot id: L0KBS2
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

748449:HALHA RS00385
gene id: 748449:HALHA_RS00385
uniprot id: L0K7J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS09215
gene id: 748449:HALHA_RS09215
uniprot id: L0KB90
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

748449:HALHA RS08995
gene id: 748449:HALHA_RS08995
uniprot id: L0K8Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS00460
gene id: 748449:HALHA_RS00460
uniprot id: L0K6W4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

748449:HALHA RS07865
gene id: 748449:HALHA_RS07865
uniprot id: L0KBS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

748449:HALHA RS00020
gene id: 748449:HALHA_RS00020
uniprot id: L0K426
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

748449:HALHA RS06485
gene id: 748449:HALHA_RS06485
uniprot id: L0KB02
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

748449:HALHA RS04040
gene id: 748449:HALHA_RS04040
uniprot id: L0K8Y0
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS08100
gene id: 748449:HALHA_RS08100
uniprot id: L0K996
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS00510
gene id: 748449:HALHA_RS00510
uniprot id: L0K6X3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

748449:HALHA RS10290
gene id: 748449:HALHA_RS10290
uniprot id: L0KC90
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

748449:HALHA RS07685
gene id: 748449:HALHA_RS07685
uniprot id: L0K899
names: Similarity
messages: Belongs to the transketolase family.

748449:HALHA RS12185
gene id: 748449:HALHA_RS12185
uniprot id: L0KBJ0
names: Similarity
messages: Belongs to the RutC family.

748449:HALHA RS01485
gene id: 748449:HALHA_RS01485
uniprot id: L0K710
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

748449:HALHA RS07580
gene id: 748449:HALHA_RS07580
uniprot id: L0K8Z2
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

748449:HALHA RS05535
gene id: 748449:HALHA_RS05535
uniprot id: L0K944
names: Similarity
messages: Belongs to the DEAD box helicase family.

748449:HALHA RS00125
gene id: 748449:HALHA_RS00125
uniprot id: L0K436
names: Similarity
messages: Belongs to the peptidase S49 family.

748449:HALHA RS05545
gene id: 748449:HALHA_RS05545
uniprot id: L0K712
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

748449:HALHA RS04820
gene id: 748449:HALHA_RS04820
uniprot id: L0KA13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

748449:HALHA RS05515
gene id: 748449:HALHA_RS05515
uniprot id: L0K941
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS02470
gene id: 748449:HALHA_RS02470
uniprot id: L0K8M7
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

748449:HALHA RS04180
gene id: 748449:HALHA_RS04180
uniprot id: L0K9R0
names: Similarity
messages: Belongs to the YggT family.

748449:HALHA RS03015
gene id: 748449:HALHA_RS03015
uniprot id: L0K5M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

748449:HALHA RS10980
gene id: 748449:HALHA_RS10980
uniprot id: L0KDF2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

748449:HALHA RS02035
gene id: 748449:HALHA_RS02035
uniprot id: L0K566
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS07785
gene id: 748449:HALHA_RS07785
uniprot id: L0K8B5
names: Function
names: Subcellular Location Annotation
messages: ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
messages: Cytoplasm

748449:HALHA RS11920
gene id: 748449:HALHA_RS11920
uniprot id: L0KE23
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS08620
gene id: 748449:HALHA_RS08620
uniprot id: L0K9K5
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

748449:HALHA RS03385
gene id: 748449:HALHA_RS03385
uniprot id: L0K967
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

748449:HALHA RS00050
gene id: 748449:HALHA_RS00050
uniprot id: L0K7F1
names: Similarity
messages: Belongs to the GerABKA family.

748449:HALHA RS11875
gene id: 748449:HALHA_RS11875
uniprot id: L0KD71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

748449:HALHA RS10530
gene id: 748449:HALHA_RS10530
uniprot id: L0K9Q5
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

748449:HALHA RS09310
gene id: 748449:HALHA_RS09310
uniprot id: L0KBS9
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

748449:HALHA RS01010
gene id: 748449:HALHA_RS01010
uniprot id: L0K6P6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

748449:HALHA RS00995
gene id: 748449:HALHA_RS00995
uniprot id: L0K4K7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

748449:HALHA RS04275
gene id: 748449:HALHA_RS04275
uniprot id: L0K6G5
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

748449:HALHA RS05090
gene id: 748449:HALHA_RS05090
uniprot id: L0K6V0
names: Similarity
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.

748449:HALHA RS00005
gene id: 748449:HALHA_RS00005
uniprot id: L0K6P5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

748449:HALHA RS00970
gene id: 748449:HALHA_RS00970
uniprot id: L0K4K3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

748449:HALHA RS09135
gene id: 748449:HALHA_RS09135
uniprot id: L0KB70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

748449:HALHA RS12115
gene id: 748449:HALHA_RS12115
uniprot id: L0KAP1
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

748449:HALHA RS03615
gene id: 748449:HALHA_RS03615
uniprot id: L0K838
names: Similarity
messages: Belongs to the BMP lipoprotein family.

748449:HALHA RS10900
gene id: 748449:HALHA_RS10900
uniprot id: L0K9W4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

748449:HALHA RS07330
gene id: 748449:HALHA_RS07330
uniprot id: L0K8U9
names: Similarity
messages: Belongs to the ThrE exporter (TC 2.A.79) family.

748449:HALHA RS05215
gene id: 748449:HALHA_RS05215
uniprot id: L0K8Z6
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

748449:HALHA RS04490
gene id: 748449:HALHA_RS04490
uniprot id: L0K950
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

748449:HALHA RS08965
gene id: 748449:HALHA_RS08965
uniprot id: L0K9P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS07875
gene id: 748449:HALHA_RS07875
uniprot id: L0KAH1
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

748449:HALHA RS00740
gene id: 748449:HALHA_RS00740
uniprot id: L0K4G3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

748449:HALHA RS01270
gene id: 748449:HALHA_RS01270
uniprot id: L0K4R8
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

748449:HALHA RS05660
gene id: 748449:HALHA_RS05660
uniprot id: L0K737
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS10105
gene id: 748449:HALHA_RS10105
uniprot id: L0KAC6
names: Similarity
messages: Belongs to the UPF0297 family.

748449:HALHA RS01460
gene id: 748449:HALHA_RS01460
uniprot id: L0K7I9
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family.

748449:HALHA RS12315
gene id: 748449:HALHA_RS12315
uniprot id: L0KAS5
names: Similarity
messages: Belongs to the glycosyl hydrolase.

748449:HALHA RS01450
gene id: 748449:HALHA_RS01450
uniprot id: L0K4X5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.

748449:HALHA RS05680
gene id: 748449:HALHA_RS05680
uniprot id: L0K743
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

748449:HALHA RS01385
gene id: 748449:HALHA_RS01385
uniprot id: L0K7H8
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS00955
gene id: 748449:HALHA_RS00955
uniprot id: L0K752
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

748449:HALHA RS04025
gene id: 748449:HALHA_RS04025
uniprot id: L0K724
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

748449:HALHA RS11395
gene id: 748449:HALHA_RS11395
uniprot id: L0KDP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

748449:HALHA RS10490
gene id: 748449:HALHA_RS10490
uniprot id: L0KD62
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS05540
gene id: 748449:HALHA_RS05540
uniprot id: L0K7S2
names: Similarity
messages: Belongs to the acylphosphatase family.

748449:HALHA RS11230
gene id: 748449:HALHA_RS11230
uniprot id: L0KC91
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

748449:HALHA RS01080
gene id: 748449:HALHA_RS01080
uniprot id: L0K780
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

748449:HALHA RS06560
gene id: 748449:HALHA_RS06560
uniprot id: L0KB32
names: Similarity
messages: Belongs to the glycosyl hydrolase.

748449:HALHA RS12040
gene id: 748449:HALHA_RS12040
uniprot id: L0KAM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

748449:HALHA RS08775
gene id: 748449:HALHA_RS08775
uniprot id: L0K8W5
names: Similarity
messages: Belongs to the GSP E family.

748449:HALHA RS04110
gene id: 748449:HALHA_RS04110
uniprot id: L0K6D9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

748449:HALHA RS06475
gene id: 748449:HALHA_RS06475
uniprot id: L0K8B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS11135
gene id: 748449:HALHA_RS11135
uniprot id: L0KC70
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

748449:HALHA RS01530
gene id: 748449:HALHA_RS01530
uniprot id: L0K7K4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

748449:HALHA RS09305
gene id: 748449:HALHA_RS09305
uniprot id: L0KCM4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

748449:HALHA RS01235
gene id: 748449:HALHA_RS01235
uniprot id: U3GL13
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

748449:HALHA RS00815
gene id: 748449:HALHA_RS00815
uniprot id: L0K7S3
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

748449:HALHA RS01560
gene id: 748449:HALHA_RS01560
uniprot id: L0K7K8
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

748449:HALHA RS06480
gene id: 748449:HALHA_RS06480
uniprot id: L0K7J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS12345
gene id: 748449:HALHA_RS12345
uniprot id: L0KE98
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.
messages: Homotetramer.

748449:HALHA RS06885
gene id: 748449:HALHA_RS06885
uniprot id: L0K7W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

748449:HALHA RS07010
gene id: 748449:HALHA_RS07010
uniprot id: L0KBB6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcAL family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS02605
gene id: 748449:HALHA_RS02605
uniprot id: L0K5E9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS09825
gene id: 748449:HALHA_RS09825
uniprot id: L0KBJ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

748449:HALHA RS09035
gene id: 748449:HALHA_RS09035
uniprot id: L0KB40
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

748449:HALHA RS00975
gene id: 748449:HALHA_RS00975
uniprot id: L0K7V7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

748449:HALHA RS00710
gene id: 748449:HALHA_RS00710
uniprot id: L0K564
names: Caution
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
messages: Belongs to the biotin--protein ligase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS05655
gene id: 748449:HALHA_RS05655
uniprot id: L0K7U7
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

748449:HALHA RS11490
gene id: 748449:HALHA_RS11490
uniprot id: L0KA89
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

748449:HALHA RS01040
gene id: 748449:HALHA_RS01040
uniprot id: L0K5C4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

748449:HALHA RS04065
gene id: 748449:HALHA_RS04065
uniprot id: L0K9P2
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

748449:HALHA RS09785
gene id: 748449:HALHA_RS09785
uniprot id: L0K9E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADH dehydrogenase family.
messages: Membrane

748449:HALHA RS04190
gene id: 748449:HALHA_RS04190
uniprot id: L0K8G4
names: Subcellular Location Annotation
messages: Cytoplasm

748449:HALHA RS03100
gene id: 748449:HALHA_RS03100
uniprot id: L0K8B4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

748449:HALHA RS02895
gene id: 748449:HALHA_RS02895
uniprot id: L0K5K1
names: Similarity
messages: Belongs to the sigma-70 factor family.

748449:HALHA RS10410
gene id: 748449:HALHA_RS10410
uniprot id: L0K9N4
names: Similarity
messages: Belongs to the NadC/ModD family.

748449:HALHA RS00980
gene id: 748449:HALHA_RS00980
uniprot id: L0K757
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

748449:HALHA RS11990
gene id: 748449:HALHA_RS11990
uniprot id: L0KAL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgH family.
messages: Cell outer membrane
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

748449:HALHA RS06370
gene id: 748449:HALHA_RS06370
uniprot id: L0K9M3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

748449:HALHA RS00040
gene id: 748449:HALHA_RS00040
uniprot id: L0K4U9
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS06160
gene id: 748449:HALHA_RS06160
uniprot id: L0KAS8
names: Similarity
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

748449:HALHA RS04370
gene id: 748449:HALHA_RS04370
uniprot id: L0K782
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

748449:HALHA RS02600
gene id: 748449:HALHA_RS02600
uniprot id: L0K656
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

748449:HALHA RS08680
gene id: 748449:HALHA_RS08680
uniprot id: L0KCA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

748449:HALHA RS00990
gene id: 748449:HALHA_RS00990
uniprot id: L0K5B2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

748449:HALHA RS07025
gene id: 748449:HALHA_RS07025
uniprot id: L0K8P7
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

748449:HALHA RS05610
gene id: 748449:HALHA_RS05610
uniprot id: L0K7T8
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

748449:HALHA RS01075
gene id: 748449:HALHA_RS01075
uniprot id: L0K7X8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

748449:HALHA RS11455
gene id: 748449:HALHA_RS11455
uniprot id: L0KCD7
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

748449:HALHA RS03450
gene id: 748449:HALHA_RS03450
uniprot id: L0K6M2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

748449:HALHA RS01595
gene id: 748449:HALHA_RS01595
uniprot id: L0K5Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS08650
gene id: 748449:HALHA_RS08650
uniprot id: L0K8U1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS06430
gene id: 748449:HALHA_RS06430
uniprot id: L0K7I7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

748449:HALHA RS01540
gene id: 748449:HALHA_RS01540
uniprot id: L0K5P7
names: Caution
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transcriptional regulator.

748449:HALHA RS00555
gene id: 748449:HALHA_RS00555
uniprot id: L0K7M6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

748449:HALHA RS03145
gene id: 748449:HALHA_RS03145
uniprot id: L0K7T7
names: Similarity
messages: Belongs to the manganese catalase family.

748449:HALHA RS08370
gene id: 748449:HALHA_RS08370
uniprot id: L0KB81
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

748449:HALHA RS04870
gene id: 748449:HALHA_RS04870
uniprot id: L0KA25
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

748449:HALHA RS07445
gene id: 748449:HALHA_RS07445
uniprot id: L0KA96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

748449:HALHA RS10860
gene id: 748449:HALHA_RS10860
uniprot id: L0KCJ0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

748449:HALHA RS05665
gene id: 748449:HALHA_RS05665
uniprot id: L0KAH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

748449:HALHA RS03445
gene id: 748449:HALHA_RS03445
uniprot id: L0K800
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

748449:HALHA RS09225
gene id: 748449:HALHA_RS09225
uniprot id: L0K952
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

748449:HALHA RS04880
gene id: 748449:HALHA_RS04880
uniprot id: L0K8T8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

748449:HALHA RS09055
gene id: 748449:HALHA_RS09055
uniprot id: L0KBL0
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

748449:HALHA RS09755
gene id: 748449:HALHA_RS09755
uniprot id: L0KA74
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

748449:HALHA RS02455
gene id: 748449:HALHA_RS02455
uniprot id: L0K7F2
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

748449:HALHA RS04350
gene id: 748449:HALHA_RS04350
uniprot id: L0K6H7
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

748449:HALHA RS09325
gene id: 748449:HALHA_RS09325
uniprot id: L0K969
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

748449:HALHA RS11950
gene id: 748449:HALHA_RS11950
uniprot id: L0KD82
names: Similarity
messages: Belongs to the Skp family.

748449:HALHA RS10455
gene id: 748449:HALHA_RS10455
uniprot id: L0KAH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

748449:HALHA RS00890
gene id: 748449:HALHA_RS00890
uniprot id: L0K4J0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

748449:HALHA RS12220
gene id: 748449:HALHA_RS12220
uniprot id: L0KE75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0756 family.
messages: Cell membrane

748449:HALHA RS00940
gene id: 748449:HALHA_RS00940
uniprot id: L0K5A2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

748449:HALHA RS01640
gene id: 748449:HALHA_RS01640
uniprot id: L0K7M0
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

748449:HALHA RS03400
gene id: 748449:HALHA_RS03400
uniprot id: L0K6L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

748449:HALHA RS10390
gene id: 748449:HALHA_RS10390
uniprot id: L0KD45
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
messages: Homohexamer.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

748449:HALHA RS03035
gene id: 748449:HALHA_RS03035
uniprot id: L0K6D7
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

748449:HALHA RS03370
gene id: 748449:HALHA_RS03370
uniprot id: L0K7Y3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS02865
gene id: 748449:HALHA_RS02865
uniprot id: L0K6A4
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

748449:HALHA RS01145
gene id: 748449:HALHA_RS01145
uniprot id: L0K4N7
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

748449:HALHA RS09450
gene id: 748449:HALHA_RS09450
uniprot id: L0K992
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

748449:HALHA RS01665
gene id: 748449:HALHA_RS01665
uniprot id: L0K7M3
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

748449:HALHA RS04020
gene id: 748449:HALHA_RS04020
uniprot id: L0K8E4
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

748449:HALHA RS07680
gene id: 748449:HALHA_RS07680
uniprot id: L0K912
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

748449:HALHA RS10085
gene id: 748449:HALHA_RS10085
uniprot id: L0K9J2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

748449:HALHA RS11640
gene id: 748449:HALHA_RS11640
uniprot id: L0KAB7
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

748449:HALHA RS07320
gene id: 748449:HALHA_RS07320
uniprot id: L0KAP0
names: Similarity
messages: Belongs to the glutamate synthase family.

748449:HALHA RS12790
gene id: 748449:HALHA_RS12790
uniprot id: L0KD65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

748449:HALHA RS02980
gene id: 748449:HALHA_RS02980
uniprot id: L0K7P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS01785
gene id: 748449:HALHA_RS01785
uniprot id: L0K7N8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

748449:HALHA RS13055
gene id: 748449:HALHA_RS13055
uniprot id: L0KAU3
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

748449:HALHA RS01090
gene id: 748449:HALHA_RS01090
uniprot id: L0K5D4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

748449:HALHA RS06195
gene id: 748449:HALHA_RS06195
uniprot id: L0K9J0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

748449:HALHA RS12540
gene id: 748449:HALHA_RS12540
uniprot id: L0KDI7
names: Similarity
messages: Belongs to the GerABKA family.

748449:HALHA RS00900
gene id: 748449:HALHA_RS00900
uniprot id: L0K7U1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

748449:HALHA RS10730
gene id: 748449:HALHA_RS10730
uniprot id: L0KAN3
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.

748449:HALHA RS03695
gene id: 748449:HALHA_RS03695
uniprot id: L0K6S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

748449:HALHA RS09950
gene id: 748449:HALHA_RS09950
uniprot id: L0KC40
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

748449:HALHA RS03985
gene id: 748449:HALHA_RS03985
uniprot id: L0K9M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS10295
gene id: 748449:HALHA_RS10295
uniprot id: L0KBR5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

748449:HALHA RS12715
gene id: 748449:HALHA_RS12715
uniprot id: L0KDM0
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

748449:HALHA RS04745
gene id: 748449:HALHA_RS04745
uniprot id: L0K9Z8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

748449:HALHA RS11295
gene id: 748449:HALHA_RS11295
uniprot id: L0KDM1
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

748449:HALHA RS06680
gene id: 748449:HALHA_RS06680
uniprot id: L0KB65
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

748449:HALHA RS10705
gene id: 748449:HALHA_RS10705
uniprot id: L0KAM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

748449:HALHA RS12745
gene id: 748449:HALHA_RS12745
uniprot id: L0KBT9
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

748449:HALHA RS10670
gene id: 748449:HALHA_RS10670
uniprot id: L0KCF9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

748449:HALHA RS04085
gene id: 748449:HALHA_RS04085
uniprot id: L0K6D6
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS08500
gene id: 748449:HALHA_RS08500
uniprot id: L0K9I1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

748449:HALHA RS08520
gene id: 748449:HALHA_RS08520
uniprot id: L0KAV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

748449:HALHA RS07710
gene id: 748449:HALHA_RS07710
uniprot id: L0K8A4
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

748449:HALHA RS01910
gene id: 748449:HALHA_RS01910
uniprot id: L0K542
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

748449:HALHA RS02985
gene id: 748449:HALHA_RS02985
uniprot id: L0K6C5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

748449:HALHA RS09970
gene id: 748449:HALHA_RS09970
uniprot id: L0KCY4
names: Function
messages: Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.

748449:HALHA RS04215
gene id: 748449:HALHA_RS04215
uniprot id: L0K8G8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

748449:HALHA RS03185
gene id: 748449:HALHA_RS03185
uniprot id: L0K923
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

748449:HALHA RS01585
gene id: 748449:HALHA_RS01585
uniprot id: L0K7L2
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

748449:HALHA RS11255
gene id: 748449:HALHA_RS11255
uniprot id: L0KC97
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

748449:HALHA RS12450
gene id: 748449:HALHA_RS12450
uniprot id: L0KDG7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.

748449:HALHA RS03705
gene id: 748449:HALHA_RS03705
uniprot id: L0K9E2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

748449:HALHA RS04090
gene id: 748449:HALHA_RS04090
uniprot id: L0K9P8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 32 family.
messages: Cytoplasm
messages: Enables the bacterium to metabolize sucrose as a sole carbon source.

748449:HALHA RS08030
gene id: 748449:HALHA_RS08030
uniprot id: L0K8F9
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

748449:HALHA RS12775
gene id: 748449:HALHA_RS12775
uniprot id: L0KB04
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

748449:HALHA RS00735
gene id: 748449:HALHA_RS00735
uniprot id: L0K569
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

748449:HALHA RS09710
gene id: 748449:HALHA_RS09710
uniprot id: L0K9D0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

748449:HALHA RS12050
gene id: 748449:HALHA_RS12050
uniprot id: L0KDA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

748449:HALHA RS05100
gene id: 748449:HALHA_RS05100
uniprot id: L0K9G3
names: Similarity
messages: Belongs to the RutC family.

748449:HALHA RS08265
gene id: 748449:HALHA_RS08265
uniprot id: L0KC06
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

748449:HALHA RS10250
gene id: 748449:HALHA_RS10250
uniprot id: L0K9L1
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS10195
gene id: 748449:HALHA_RS10195
uniprot id: L0K9K3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

748449:HALHA RS03480
gene id: 748449:HALHA_RS03480
uniprot id: L0K5X7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

748449:HALHA RS07670
gene id: 748449:HALHA_RS07670
uniprot id: L0KAV6
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

748449:HALHA RS08570
gene id: 748449:HALHA_RS08570
uniprot id: L0K9J5
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

748449:HALHA RS01620
gene id: 748449:HALHA_RS01620
uniprot id: L0K5Q9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

748449:HALHA RS07760
gene id: 748449:HALHA_RS07760
uniprot id: L0K8B1
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.

748449:HALHA RS06940
gene id: 748449:HALHA_RS06940
uniprot id: L0KAH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

748449:HALHA RS07695
gene id: 748449:HALHA_RS07695
uniprot id: L0KAW1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

748449:HALHA RS04645
gene id: 748449:HALHA_RS04645
uniprot id: L0K8P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS08675
gene id: 748449:HALHA_RS08675
uniprot id: L0K8U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

748449:HALHA RS08955
gene id: 748449:HALHA_RS08955
uniprot id: L0KBI7
names: Similarity
messages: Belongs to the glycosyltransferase 1 family.

748449:HALHA RS01895
gene id: 748449:HALHA_RS01895
uniprot id: L0K7Q0
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

748449:HALHA RS05575
gene id: 748449:HALHA_RS05575
uniprot id: L0KAF2
names: Cofactor
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.

748449:HALHA RS02460
gene id: 748449:HALHA_RS02460
uniprot id: L0K628
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

748449:HALHA RS04115
gene id: 748449:HALHA_RS04115
uniprot id: L0K9Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

748449:HALHA RS09085
gene id: 748449:HALHA_RS09085
uniprot id: L0KB51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

748449:HALHA RS08035
gene id: 748449:HALHA_RS08035
uniprot id: L0KBV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

748449:HALHA RS06880
gene id: 748449:HALHA_RS06880
uniprot id: L0K8L9
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

748449:HALHA RS04175
gene id: 748449:HALHA_RS04175
uniprot id: L0K6E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

748449:HALHA RS00720
gene id: 748449:HALHA_RS00720
uniprot id: L0K7Q4
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

748449:HALHA RS11860
gene id: 748449:HALHA_RS11860
uniprot id: L0KBD0
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS07140
gene id: 748449:HALHA_RS07140
uniprot id: L0KAK8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.

748449:HALHA RS01985
gene id: 748449:HALHA_RS01985
uniprot id: L0K556
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

748449:HALHA RS06705
gene id: 748449:HALHA_RS06705
uniprot id: L0KB69
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

748449:HALHA RS01120
gene id: 748449:HALHA_RS01120
uniprot id: L0K4N3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the energy-coupling factor EcfT family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).
messages: Membrane
messages: Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.

748449:HALHA RS00145
gene id: 748449:HALHA_RS00145
uniprot id: L0K4V7
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

748449:HALHA RS10835
gene id: 748449:HALHA_RS10835
uniprot id: L0KCI6
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS05905
gene id: 748449:HALHA_RS05905
uniprot id: L0K9C9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

748449:HALHA RS07740
gene id: 748449:HALHA_RS07740
uniprot id: L0KBQ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

748449:HALHA RS12710
gene id: 748449:HALHA_RS12710
uniprot id: L0KEH7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

748449:HALHA RS02595
gene id: 748449:HALHA_RS02595
uniprot id: L0K7H6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

748449:HALHA RS04830
gene id: 748449:HALHA_RS04830
uniprot id: L0K8S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

748449:HALHA RS01405
gene id: 748449:HALHA_RS01405
uniprot id: L0K872
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport.

748449:HALHA RS10110
gene id: 748449:HALHA_RS10110
uniprot id: L0K9J7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

748449:HALHA RS08685
gene id: 748449:HALHA_RS08685
uniprot id: L0KBF2
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS05110
gene id: 748449:HALHA_RS05110
uniprot id: L0K7K9
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.

748449:HALHA RS08495
gene id: 748449:HALHA_RS08495
uniprot id: L0KAV4
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

748449:HALHA RS03960
gene id: 748449:HALHA_RS03960
uniprot id: L0K8W2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

748449:HALHA RS06155
gene id: 748449:HALHA_RS06155
uniprot id: L0K7D6
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

748449:HALHA RS02790
gene id: 748449:HALHA_RS02790
uniprot id: L0K854
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

748449:HALHA RS04225
gene id: 748449:HALHA_RS04225
uniprot id: L0K6F8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS01000
gene id: 748449:HALHA_RS01000
uniprot id: L0K7W2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

748449:HALHA RS01305
gene id: 748449:HALHA_RS01305
uniprot id: L0K7D4
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

748449:HALHA RS11960
gene id: 748449:HALHA_RS11960
uniprot id: L0KBF0
names: Similarity
messages: Belongs to the Skp family.

748449:HALHA RS02505
gene id: 748449:HALHA_RS02505
uniprot id: L0K7F8
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

748449:HALHA RS08375
gene id: 748449:HALHA_RS08375
uniprot id: L0K9F3
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

748449:HALHA RS01495
gene id: 748449:HALHA_RS01495
uniprot id: L0K4Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein bS18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

748449:HALHA RS10775
gene id: 748449:HALHA_RS10775
uniprot id: L0KDB2
names: Similarity
messages: Belongs to the peptidase S41A family.

748449:HALHA RS06525
gene id: 748449:HALHA_RS06525
uniprot id: L0K8C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS01430
gene id: 748449:HALHA_RS01430
uniprot id: L0K874
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

748449:HALHA RS08755
gene id: 748449:HALHA_RS08755
uniprot id: L0KCC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Membrane

748449:HALHA RS01965
gene id: 748449:HALHA_RS01965
uniprot id: L0K8E3
names: Similarity
messages: Belongs to the TrpF family.

748449:HALHA RS09300
gene id: 748449:HALHA_RS09300
uniprot id: L0K964
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

748449:HALHA RS13160
gene id: 748449:HALHA_RS13160
uniprot id: L0KCN1
names: Similarity
messages: Belongs to the bacterial flagellin family.

748449:HALHA RS11985
gene id: 748449:HALHA_RS11985
uniprot id: L0KBF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgI family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

748449:HALHA RS01055
gene id: 748449:HALHA_RS01055
uniprot id: L0K774
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

748449:HALHA RS08095
gene id: 748449:HALHA_RS08095
uniprot id: L0KAL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methylaspartate mutase GlmS subunit family.
messages: Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).
messages: Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.

748449:HALHA RS04405
gene id: 748449:HALHA_RS04405
uniprot id: L0K9T9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

748449:HALHA RS11275
gene id: 748449:HALHA_RS11275
uniprot id: L0KCQ9
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

748449:HALHA RS11720
gene id: 748449:HALHA_RS11720
uniprot id: L0KDW5
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS03625
gene id: 748449:HALHA_RS03625
uniprot id: L0K609
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS03365
gene id: 748449:HALHA_RS03365
uniprot id: L0K8G2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS06755
gene id: 748449:HALHA_RS06755
uniprot id: L0KB77
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

748449:HALHA RS08665
gene id: 748449:HALHA_RS08665
uniprot id: L0KAZ0
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS09905
gene id: 748449:HALHA_RS09905
uniprot id: L0KA98
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

748449:HALHA RS12700
gene id: 748449:HALHA_RS12700
uniprot id: L0KBT1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

748449:HALHA RS04240
gene id: 748449:HALHA_RS04240
uniprot id: L0K8H2
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS10710
gene id: 748449:HALHA_RS10710
uniprot id: L0K9T4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

748449:HALHA RS12070
gene id: 748449:HALHA_RS12070
uniprot id: L0KE44
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

748449:HALHA RS05280
gene id: 748449:HALHA_RS05280
uniprot id: L0K7N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

748449:HALHA RS04780
gene id: 748449:HALHA_RS04780
uniprot id: L0K8S0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS03260
gene id: 748449:HALHA_RS03260
uniprot id: L0K939
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

748449:HALHA RS07775
gene id: 748449:HALHA_RS07775
uniprot id: L0KAF4
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

748449:HALHA RS06455
gene id: 748449:HALHA_RS06455
uniprot id: L0K7J3
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.

748449:HALHA RS12895
gene id: 748449:HALHA_RS12895
uniprot id: L0KBW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

748449:HALHA RS02535
gene id: 748449:HALHA_RS02535
uniprot id: L0K5D5
names: Similarity
messages: Belongs to the EamA transporter family.

748449:HALHA RS05235
gene id: 748449:HALHA_RS05235
uniprot id: L0K9I4
names: Similarity
messages: Belongs to the carbamate kinase family.

748449:HALHA RS07370
gene id: 748449:HALHA_RS07370
uniprot id: L0KAP7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

748449:HALHA RS11840
gene id: 748449:HALHA_RS11840
uniprot id: L0KAI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

748449:HALHA RS00800
gene id: 748449:HALHA_RS00800
uniprot id: L0K6L2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DisA family.
messages: Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
messages: Homooctamer.
messages: Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, DisA pauses at the lesion site. This triggers a cellular response that culminates in a temporary block in sporulation initiation.

748449:HALHA RS04425
gene id: 748449:HALHA_RS04425
uniprot id: L0K6J1
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

748449:HALHA RS01905
gene id: 748449:HALHA_RS01905
uniprot id: L0K5U9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

748449:HALHA RS12750
gene id: 748449:HALHA_RS12750
uniprot id: L0KB00
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

748449:HALHA RS02780
gene id: 748449:HALHA_RS02780
uniprot id: L0K5H8
names: Similarity
messages: Belongs to the TlyA family.

748449:HALHA RS12395
gene id: 748449:HALHA_RS12395
uniprot id: L0KEB3
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

748449:HALHA RS04515
gene id: 748449:HALHA_RS04515
uniprot id: L0K955
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

748449:HALHA RS07905
gene id: 748449:HALHA_RS07905
uniprot id: L0K953
names: Similarity
messages: Belongs to the AAA ATPase family.
messages: In the C-terminal section; belongs to the peptidase M41 family.

748449:HALHA RS11580
gene id: 748449:HALHA_RS11580
uniprot id: L0KCG4
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

748449:HALHA RS03880
gene id: 748449:HALHA_RS03880
uniprot id: L0K9I2
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS09170
gene id: 748449:HALHA_RS09170
uniprot id: L0K937
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

748449:HALHA RS04375
gene id: 748449:HALHA_RS04375
uniprot id: L0K6I1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

748449:HALHA RS09155
gene id: 748449:HALHA_RS09155
uniprot id: L0KBP7
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

748449:HALHA RS12655
gene id: 748449:HALHA_RS12655
uniprot id: L0KAY3
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS08635
gene id: 748449:HALHA_RS08635
uniprot id: L0KBE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

748449:HALHA RS06100
gene id: 748449:HALHA_RS06100
uniprot id: L0KAR9
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

748449:HALHA RS03265
gene id: 748449:HALHA_RS03265
uniprot id: L0K8E1
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Membrane

748449:HALHA RS06015
gene id: 748449:HALHA_RS06015
uniprot id: L0K820
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

748449:HALHA RS12605
gene id: 748449:HALHA_RS12605
uniprot id: L0KAX6
names: Similarity
messages: Belongs to the peptidase S58 family.

748449:HALHA RS07360
gene id: 748449:HALHA_RS07360
uniprot id: L0K843
names: Similarity
messages: Belongs to the ETF-QO/FixC family.

748449:HALHA RS06450
gene id: 748449:HALHA_RS06450
uniprot id: L0K8A7
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

748449:HALHA RS12365
gene id: 748449:HALHA_RS12365
uniprot id: L0KAT4
names: Similarity
messages: Belongs to the IlvD/Edd family.

748449:HALHA RS11835
gene id: 748449:HALHA_RS11835
uniprot id: L0KBC6
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

748449:HALHA RS04205
gene id: 748449:HALHA_RS04205
uniprot id: L0K9R4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

748449:HALHA RS12045
gene id: 748449:HALHA_RS12045
uniprot id: L0KE40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

748449:HALHA RS06040
gene id: 748449:HALHA_RS06040
uniprot id: L0K826
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

748449:HALHA RS10240
gene id: 748449:HALHA_RS10240
uniprot id: L0KBQ4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

748449:HALHA RS12770
gene id: 748449:HALHA_RS12770
uniprot id: L0KBU6
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS03170
gene id: 748449:HALHA_RS03170
uniprot id: L0K7U3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

748449:HALHA RS00475
gene id: 748449:HALHA_RS00475
uniprot id: L0K4A5
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

748449:HALHA RS00840
gene id: 748449:HALHA_RS00840
uniprot id: L0K7S9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

748449:HALHA RS12105
gene id: 748449:HALHA_RS12105
uniprot id: L0KCT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

748449:HALHA RS02770
gene id: 748449:HALHA_RS02770
uniprot id: L0K7L0
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

748449:HALHA RS02880
gene id: 748449:HALHA_RS02880
uniprot id: L0K869
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

748449:HALHA RS02710
gene id: 748449:HALHA_RS02710
uniprot id: L0K8S6
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

748449:HALHA RS05020
gene id: 748449:HALHA_RS05020
uniprot id: L0KA53
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

748449:HALHA RS06515
gene id: 748449:HALHA_RS06515
uniprot id: L0KA73
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

748449:HALHA RS07770
gene id: 748449:HALHA_RS07770
uniprot id: L0KAX7
names: Similarity
messages: Belongs to the UPF0735 family.

748449:HALHA RS05645
gene id: 748449:HALHA_RS05645
uniprot id: L0K9Q0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

748449:HALHA RS09385
gene id: 748449:HALHA_RS09385
uniprot id: L0KBU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

748449:HALHA RS04265
gene id: 748449:HALHA_RS04265
uniprot id: L0K8H7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

748449:HALHA RS11650
gene id: 748449:HALHA_RS11650
uniprot id: L0KCZ7
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

748449:HALHA RS04680
gene id: 748449:HALHA_RS04680
uniprot id: L0K9Y3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

748449:HALHA RS11625
gene id: 748449:HALHA_RS11625
uniprot id: L0KCZ1
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

748449:HALHA RS01865
gene id: 748449:HALHA_RS01865
uniprot id: L0K8C9
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

748449:HALHA RS02725
gene id: 748449:HALHA_RS02725
uniprot id: L0K678
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

748449:HALHA RS01085
gene id: 748449:HALHA_RS01085
uniprot id: L0K6R2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

748449:HALHA RS11260
gene id: 748449:HALHA_RS11260
uniprot id: L0KAY5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

748449:HALHA RS10115
gene id: 748449:HALHA_RS10115
uniprot id: L0KD07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

748449:HALHA RS10895
gene id: 748449:HALHA_RS10895
uniprot id: L0KAR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

748449:HALHA RS12870
gene id: 748449:HALHA_RS12870
uniprot id: L0KBW0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

748449:HALHA RS00055
gene id: 748449:HALHA_RS00055
uniprot id: L0K6Q3
names: Similarity
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.

748449:HALHA RS03060
gene id: 748449:HALHA_RS03060
uniprot id: L0K6E2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

748449:HALHA RS10225
gene id: 748449:HALHA_RS10225
uniprot id: L0KD20
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS04610
gene id: 748449:HALHA_RS04610
uniprot id: L0K9W7
names: Similarity
messages: Belongs to the disproportionating enzyme family.

748449:HALHA RS07425
gene id: 748449:HALHA_RS07425
uniprot id: L0K8W6
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

748449:HALHA RS06730
gene id: 748449:HALHA_RS06730
uniprot id: L0KB74
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

748449:HALHA RS08610
gene id: 748449:HALHA_RS08610
uniprot id: L0KBD5
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

748449:HALHA RS04170
gene id: 748449:HALHA_RS04170
uniprot id: L0K747
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

748449:HALHA RS09340
gene id: 748449:HALHA_RS09340
uniprot id: L0KBB0
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Autoproteolytically processed. The inactive tetrameric zymogen termed p46 autoprocesses to a smaller form termed p41, which is active only during spore germination.
messages: Belongs to the peptidase A25 family.
messages: Homotetramer.
messages: Initiates the rapid degradation of small, acid-soluble proteins during spore germination.

748449:HALHA RS01855
gene id: 748449:HALHA_RS01855
uniprot id: L0K5U1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS01980
gene id: 748449:HALHA_RS01980
uniprot id: L0K5W3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

748449:HALHA RS13170
gene id: 748449:HALHA_RS13170
uniprot id: L0KCV8
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

748449:HALHA RS11265
gene id: 748449:HALHA_RS11265
uniprot id: L0KA42
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

748449:HALHA RS09115
gene id: 748449:HALHA_RS09115
uniprot id: L0K9T1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

748449:HALHA RS00035
gene id: 748449:HALHA_RS00035
uniprot id: L0K684
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

748449:HALHA RS12690
gene id: 748449:HALHA_RS12690
uniprot id: L0KDL5
names: Similarity
messages: Belongs to the GARS family.

748449:HALHA RS07590
gene id: 748449:HALHA_RS07590
uniprot id: L0KBM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS04035
gene id: 748449:HALHA_RS04035
uniprot id: L0K9N8
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS13195
gene id: 748449:HALHA_RS13195
uniprot id: L0KCQ2
names: Similarity
messages: Belongs to the peptidase S8 family.

748449:HALHA RS06145
gene id: 748449:HALHA_RS06145
uniprot id: L0K9H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

748449:HALHA RS02335
gene id: 748449:HALHA_RS02335
uniprot id: L0K5A1
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

748449:HALHA RS12955
gene id: 748449:HALHA_RS12955
uniprot id: L0K816
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

748449:HALHA RS08060
gene id: 748449:HALHA_RS08060
uniprot id: L0KBW2
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS06675
gene id: 748449:HALHA_RS06675
uniprot id: L0K7S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

748449:HALHA RS01535
gene id: 748449:HALHA_RS01535
uniprot id: L0K716
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

748449:HALHA RS01975
gene id: 748449:HALHA_RS01975
uniprot id: L0K781
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

748449:HALHA RS07755
gene id: 748449:HALHA_RS07755
uniprot id: L0K928
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

748449:HALHA RS12685
gene id: 748449:HALHA_RS12685
uniprot id: L0KEH3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS11115
gene id: 748449:HALHA_RS11115
uniprot id: L0KA06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
messages: Belongs to the FliW family.
messages: Cytoplasm
messages: Interacts with translational regulator CsrA and flagellin(s).

748449:HALHA RS09420
gene id: 748449:HALHA_RS09420
uniprot id: L0KA09
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS03075
gene id: 748449:HALHA_RS03075
uniprot id: L0K8B0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

748449:HALHA RS08355
gene id: 748449:HALHA_RS08355
uniprot id: L0K9E9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

748449:HALHA RS03390
gene id: 748449:HALHA_RS03390
uniprot id: L0K8G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

748449:HALHA RS00505
gene id: 748449:HALHA_RS00505
uniprot id: L0K7L7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS01940
gene id: 748449:HALHA_RS01940
uniprot id: L0K8D9
names: Similarity
names: Subunit
messages: Belongs to the MtrB family.
messages: Oligomer of 11 identical subunits arranged in doughnut-like structure.

748449:HALHA RS11970
gene id: 748449:HALHA_RS11970
uniprot id: L0KE32
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS06750
gene id: 748449:HALHA_RS06750
uniprot id: L0K7T5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

748449:HALHA RS04910
gene id: 748449:HALHA_RS04910
uniprot id: L0K7H3
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

748449:HALHA RS02180
gene id: 748449:HALHA_RS02180
uniprot id: L0K7V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS01990
gene id: 748449:HALHA_RS01990
uniprot id: L0K8E7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS03455
gene id: 748449:HALHA_RS03455
uniprot id: L0K5X4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

748449:HALHA RS06180
gene id: 748449:HALHA_RS06180
uniprot id: L0K7E1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

748449:HALHA RS10475
gene id: 748449:HALHA_RS10475
uniprot id: L0KBU9
names: Similarity
messages: Belongs to the threonine synthase family.

748449:HALHA RS12500
gene id: 748449:HALHA_RS12500
uniprot id: L0KBP2
names: Similarity
messages: Belongs to the manganese catalase family.

748449:HALHA RS12570
gene id: 748449:HALHA_RS12570
uniprot id: L0KD21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

748449:HALHA RS01195
gene id: 748449:HALHA_RS01195
uniprot id: L0K4Q0
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

748449:HALHA RS01515
gene id: 748449:HALHA_RS01515
uniprot id: L0K5P2
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

748449:HALHA RS08310
gene id: 748449:HALHA_RS08310
uniprot id: L0K8L8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

748449:HALHA RS07150
gene id: 748449:HALHA_RS07150
uniprot id: L0K8R8
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS02140
gene id: 748449:HALHA_RS02140
uniprot id: L0K5Y6
names: Similarity
messages: Belongs to the peptidase U62 family.

748449:HALHA RS11220
gene id: 748449:HALHA_RS11220
uniprot id: L0KDK4
names: Function
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.

748449:HALHA RS12780
gene id: 748449:HALHA_RS12780
uniprot id: L0KEJ1
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

748449:HALHA RS05335
gene id: 748449:HALHA_RS05335
uniprot id: L0K914
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

748449:HALHA RS02515
gene id: 748449:HALHA_RS02515
uniprot id: L0K5D0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

748449:HALHA RS03465
gene id: 748449:HALHA_RS03465
uniprot id: L0K8I3
names: Similarity
messages: Belongs to the ribF family.

748449:HALHA RS12090
gene id: 748449:HALHA_RS12090
uniprot id: L0KAN5
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS03085
gene id: 748449:HALHA_RS03085
uniprot id: L0K6E7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

748449:HALHA RS01960
gene id: 748449:HALHA_RS01960
uniprot id: L0K552
names: Similarity
messages: Belongs to the TrpC family.

748449:HALHA RS12545
gene id: 748449:HALHA_RS12545
uniprot id: L0KD15
names: Similarity
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.

748449:HALHA RS10845
gene id: 748449:HALHA_RS10845
uniprot id: L0KAQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

748449:HALHA RS01970
gene id: 748449:HALHA_RS01970
uniprot id: L0K7R2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

748449:HALHA RS00290
gene id: 748449:HALHA_RS00290
uniprot id: L0K6T2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

748449:HALHA RS00820
gene id: 748449:HALHA_RS00820
uniprot id: L0K720
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS12550
gene id: 748449:HALHA_RS12550
uniprot id: L0KBQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS11235
gene id: 748449:HALHA_RS11235
uniprot id: L0KAY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LPG synthase family.
messages: Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.
messages: Cell membrane
messages: Membrane

748449:HALHA RS03825
gene id: 748449:HALHA_RS03825
uniprot id: L0K9G9
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

748449:HALHA RS01135
gene id: 748449:HALHA_RS01135
uniprot id: L0K6S1
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

748449:HALHA RS08920
gene id: 748449:HALHA_RS08920
uniprot id: L0K8W8
names: Similarity
messages: Belongs to the IMPACT family.

748449:HALHA RS03605
gene id: 748449:HALHA_RS03605
uniprot id: L0K9B9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Homohexamer. Forms a ring that surrounds DNA.
messages: Membrane

748449:HALHA RS07470
gene id: 748449:HALHA_RS07470
uniprot id: L0KAA0
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

748449:HALHA RS09800
gene id: 748449:HALHA_RS09800
uniprot id: L0KBJ1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

748449:HALHA RS04130
gene id: 748449:HALHA_RS04130
uniprot id: L0K742
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

748449:HALHA RS07880
gene id: 748449:HALHA_RS07880
uniprot id: L0K948
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

748449:HALHA RS04120
gene id: 748449:HALHA_RS04120
uniprot id: L0K900
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

748449:HALHA RS13175
gene id: 748449:HALHA_RS13175
uniprot id: L0KD09
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS01050
gene id: 748449:HALHA_RS01050
uniprot id: L0K7X2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

748449:HALHA RS08420
gene id: 748449:HALHA_RS08420
uniprot id: L0KAT7
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 51 family.
messages: Homohexamer; trimer of dimers.

748449:HALHA RS04325
gene id: 748449:HALHA_RS04325
uniprot id: L0K6H4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

748449:HALHA RS07475
gene id: 748449:HALHA_RS07475
uniprot id: L0K8X4
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS09955
gene id: 748449:HALHA_RS09955
uniprot id: L0KBL8
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

748449:HALHA RS06645
gene id: 748449:HALHA_RS06645
uniprot id: L0K8H6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

748449:HALHA RS06540
gene id: 748449:HALHA_RS06540
uniprot id: L0KA78
names: Function
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.
messages: Transcriptional repressor of xylose-utilizing enzymes.

748449:HALHA RS02135
gene id: 748449:HALHA_RS02135
uniprot id: L0K7A8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

748449:HALHA RS00060
gene id: 748449:HALHA_RS00060
uniprot id: L0K688
names: Similarity
messages: Belongs to the GerABKC lipoprotein family.

748449:HALHA RS04850
gene id: 748449:HALHA_RS04850
uniprot id: L0K9B7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.

748449:HALHA RS06840
gene id: 748449:HALHA_RS06840
uniprot id: L0K7V4
names: Function
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily.
messages: Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC).

748449:HALHA RS05685
gene id: 748449:HALHA_RS05685
uniprot id: L0KAI0
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS03255
gene id: 748449:HALHA_RS03255
uniprot id: L0K5S6
names: Similarity
messages: Belongs to the MotB family.

748449:HALHA RS08660
gene id: 748449:HALHA_RS08660
uniprot id: L0KBE7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS03760
gene id: 748449:HALHA_RS03760
uniprot id: L0K8Q3
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS12005
gene id: 748449:HALHA_RS12005
uniprot id: L0KCR4
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

748449:HALHA RS01240
gene id: 748449:HALHA_RS01240
uniprot id: L0K5G4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

748449:HALHA RS04885
gene id: 748449:HALHA_RS04885
uniprot id: L0K7G9
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

748449:HALHA RS01945
gene id: 748449:HALHA_RS01945
uniprot id: L0K7Q8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

748449:HALHA RS03805
gene id: 748449:HALHA_RS03805
uniprot id: L0K8R6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates zinc uptake. May also transport other divalent cations.
messages: Membrane

748449:HALHA RS04635
gene id: 748449:HALHA_RS04635
uniprot id: L0K9X2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flotillin-like FloA family.
messages: Cell membrane
messages: Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.
messages: Homooligomerizes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

748449:HALHA RS02885
gene id: 748449:HALHA_RS02885
uniprot id: L0K7N1
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

748449:HALHA RS01395
gene id: 748449:HALHA_RS01395
uniprot id: L0K5M2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

748449:HALHA RS09375
gene id: 748449:HALHA_RS09375
uniprot id: L0K979
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS11505
gene id: 748449:HALHA_RS11505
uniprot id: L0KCE7
names: Similarity
messages: Belongs to the hemerythrin family.

748449:HALHA RS04210
gene id: 748449:HALHA_RS04210
uniprot id: L0K913
names: Similarity
messages: Belongs to the RemA family.

748449:HALHA RS07660
gene id: 748449:HALHA_RS07660
uniprot id: L0K894
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

748449:HALHA RS11360
gene id: 748449:HALHA_RS11360
uniprot id: L0KB06
names: Similarity
messages: Belongs to the mannitol dehydrogenase family.

748449:HALHA RS12065
gene id: 748449:HALHA_RS12065
uniprot id: L0KAN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

748449:HALHA RS02765
gene id: 748449:HALHA_RS02765
uniprot id: L0K848
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

748449:HALHA RS00355
gene id: 748449:HALHA_RS00355
uniprot id: L0K479
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

748449:HALHA RS00540
gene id: 748449:HALHA_RS00540
uniprot id: L0K6G0
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS04220
gene id: 748449:HALHA_RS04220
uniprot id: L0K755
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

748449:HALHA RS04390
gene id: 748449:HALHA_RS04390
uniprot id: L0K8J9
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

748449:HALHA RS10045
gene id: 748449:HALHA_RS10045
uniprot id: L0KC52
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

748449:HALHA RS11095
gene id: 748449:HALHA_RS11095
uniprot id: L0KDH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

748449:HALHA RS08325
gene id: 748449:HALHA_RS08325
uniprot id: L0KAR5
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

748449:HALHA RS09200
gene id: 748449:HALHA_RS09200
uniprot id: L0K947
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

748449:HALHA RS12335
gene id: 748449:HALHA_RS12335
uniprot id: L0KBL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS06900
gene id: 748449:HALHA_RS06900
uniprot id: L0KA05
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

748449:HALHA RS09750
gene id: 748449:HALHA_RS09750
uniprot id: L0KBI1
names: Similarity
messages: Belongs to the UPF0758 family.

748449:HALHA RS03180
gene id: 748449:HALHA_RS03180
uniprot id: L0K5R0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

748449:HALHA RS08985
gene id: 748449:HALHA_RS08985
uniprot id: L0KB31
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

748449:HALHA RS03105
gene id: 748449:HALHA_RS03105
uniprot id: L0K7S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Cell membrane
messages: Membrane

748449:HALHA RS04255
gene id: 748449:HALHA_RS04255
uniprot id: L0K9R9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

748449:HALHA RS10690
gene id: 748449:HALHA_RS10690
uniprot id: L0KD98
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

748449:HALHA RS12465
gene id: 748449:HALHA_RS12465
uniprot id: L0KAV0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

748449:HALHA RS12640
gene id: 748449:HALHA_RS12640
uniprot id: L0KDK6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

748449:HALHA RS03470
gene id: 748449:HALHA_RS03470
uniprot id: L0K805
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

748449:HALHA RS00950
gene id: 748449:HALHA_RS00950
uniprot id: L0K7V1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

748449:HALHA RS06655
gene id: 748449:HALHA_RS06655
uniprot id: L0KB61
names: Similarity
messages: Belongs to the UPF0045 family.

748449:HALHA RS10885
gene id: 748449:HALHA_RS10885
uniprot id: L0KCJ5
names: Subcellular Location Annotation
messages: Membrane

748449:HALHA RS06120
gene id: 748449:HALHA_RS06120
uniprot id: L0K9H3
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

748449:HALHA RS04525
gene id: 748449:HALHA_RS04525
uniprot id: L0K7A4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

748449:HALHA RS03110
gene id: 748449:HALHA_RS03110
uniprot id: L0K6E9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

748449:HALHA RS02170
gene id: 748449:HALHA_RS02170
uniprot id: L0K587
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

748449:HALHA RS09110
gene id: 748449:HALHA_RS09110
uniprot id: L0KB56
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.