70601:PH RS00680
gene id: 70601:PH_RS00680
uniprot id: O57882
names: Function
names: Similarity
messages: Belongs to the 2-phosphoglycerate kinase family.
messages: Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.

70601:PH RS03215
gene id: 70601:PH_RS03215
uniprot id: O58419
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

70601:PH RS05020
gene id: 70601:PH_RS05020
uniprot id: O58796
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

70601:PH RS01055
gene id: 70601:PH_RS01055
uniprot id: O57971
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the Ntn-hydrolase family.
messages: Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity (By similarity).
messages: Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer (By similarity).

70601:PH RS08705
gene id: 70601:PH_RS08705
uniprot id: O59511
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

70601:PH RS08050
gene id: 70601:PH_RS08050
uniprot id: O59410
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

70601:PH RS07400
gene id: 70601:PH_RS07400
uniprot id: O59209
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

70601:PH RS06395
gene id: 70601:PH_RS06395
uniprot id: O59073
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

70601:PH RS08850
gene id: 70601:PH_RS08850
uniprot id: O59545
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

70601:PH RS01300
gene id: 70601:PH_RS01300
uniprot id: O58028
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

70601:PH RS07285
gene id: 70601:PH_RS07285
uniprot id: O59229
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

70601:PH RS09410
gene id: 70601:PH_RS09410
uniprot id: O57711
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

70601:PH RS01795
gene id: 70601:PH_RS01795
uniprot id: O58134
names: Similarity
messages: Belongs to the CDP-glycerol glycerophosphotransferase family.

70601:PH RS09420
gene id: 70601:PH_RS09420
uniprot id: O57709
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

70601:PH RS09445
gene id: 70601:PH_RS09445
uniprot id: O57705
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. The stalk complex of P.horikoshii binds to E.coli large subunits and confers on them the ability to interact with eukaryotic elongation factors. Each succesive P1 dimer bound along the P0 spine increases the GTPase activity of elongation factors and increases translation by reconsituted ribosomes.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric uL10/P0(P1)2(P1)2(P1)2 complex, where uL10/P0 forms an elongated spine to which the P1 dimers bind in a sequential fashion.

70601:PH RS08340
gene id: 70601:PH_RS08340
uniprot id: O59429
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

70601:PH RS08390
gene id: 70601:PH_RS08390
uniprot id: O74095
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

70601:PH RS00240
gene id: 70601:PH_RS00240
uniprot id: O57812
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS08975
gene id: 70601:PH_RS08975
uniprot id: O74104
names: Function
messages: Probably involved in the biogenesis of the ribosome.

70601:PH RS07180
gene id: 70601:PH_RS07180
uniprot id: O59188
names: Activity Regulation
names: Function
names: Subunit
messages: DNA-binding protein involved in the repression of transcription of a large number of genes, thereby arresting growth, in response to environmental changes (PubMed:14976242, PubMed:18073105). Binding sites are identified in promoters of approximately 200 transcription units, including genes involved in ATP synthesis, transmembrane transport, translation and DNA synthesis (PubMed:18073105).
messages: Homodimer (PubMed:14976242, PubMed:18073105, PubMed:19004003). Binds DNA as a dimer and an octamer (PubMed:18073105, PubMed:19004003). The octamer formed with lysine is stable in solution, but the octamer formed with arginine is unstable without DNA (PubMed:19004003). When crystallized in the absence of DNA, dimers are assembled into helical cylinders with six dimers per turn (PubMed:14976242). In solution, predominantly behaves as a dimer (PubMed:14976242).
messages: In the famine mode, FL11 forms dimers and acts as a repressor, leading to growth arrest (PubMed:18073105). In the feast mode, in the presence of high concentrations of lysine or arginine, four dimers assemble into an octamer and cover the fl11 and lysine biosynthesis promoters (PubMed:18073105, PubMed:19004003). This leads to the inhibition of fl11 expression and lysine biosynthesis, decrease of the FL11 concentration in the cell, derepression of the target genes and activation of the metabolism (PubMed:18073105).

70601:PH RS00565
gene id: 70601:PH_RS00565
uniprot id: O57863
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).

70601:PH RS02060
gene id: 70601:PH_RS02060
uniprot id: O73972
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

70601:PH RS08090
gene id: 70601:PH_RS08090
uniprot id: O59402
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family. LysK subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
messages: Cytoplasm

70601:PH RS08980
gene id: 70601:PH_RS08980
uniprot id: O74105
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

70601:PH RS09015
gene id: 70601:PH_RS09015
uniprot id: O59570
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

70601:PH RS00820
gene id: 70601:PH_RS00820
uniprot id: O57920
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

70601:PH RS04400
gene id: 70601:PH_RS04400
uniprot id: O58686
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

70601:PH RS08715
gene id: 70601:PH_RS08715
uniprot id: O59508
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS06465
gene id: 70601:PH_RS06465
uniprot id: O59086
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

70601:PH RS05725
gene id: 70601:PH_RS05725
uniprot id: O58964
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the N-terminal section; belongs to the MobA family.

70601:PH RS07530
gene id: 70601:PH_RS07530
uniprot id: P0CL73
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Cytoplasm
messages: Homohexamer.

70601:PH RS03805
gene id: 70601:PH_RS03805
uniprot id: O58539
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

70601:PH RS02095
gene id: 70601:PH_RS02095
uniprot id: O58181
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

70601:PH RS06770
gene id: 70601:PH_RS06770
uniprot id: O59101
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS04175
gene id: 70601:PH_RS04175
uniprot id: O58614
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Membrane

70601:PH RS01665
gene id: 70601:PH_RS01665
uniprot id: O58111
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.

70601:PH RS07295
gene id: 70601:PH_RS07295
uniprot id: O74018
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

70601:PH RS08655
gene id: 70601:PH_RS08655
uniprot id: O59499
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

70601:PH RS08285
gene id: 70601:PH_RS08285
uniprot id: O59441
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

70601:PH RS07810
gene id: 70601:PH_RS07810
uniprot id: O59346
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

70601:PH RS09285
gene id: 70601:PH_RS09285
uniprot id: O59613
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

70601:PH RS02355
gene id: 70601:PH_RS02355
uniprot id: O58240
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

70601:PH RS07510
gene id: 70601:PH_RS07510
uniprot id: O59259
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

70601:PH RS09450
gene id: 70601:PH_RS09450
uniprot id: O74109
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms the large subunit's ribosomal stalk, playing a central role in the interaction of the ribosome with elongation factors; the stalk complex of P.horikoshii binds to E.coli large subunits and confers on them the ability to interact with eukaryotic elongation factors. Each succesive L12 dimer bound along the P0 spine increases the GTPase activity of elongation factors and increases translation by reconsituted ribosomes, although the first site is the most stimulatory.
messages: Part of the 50S ribosomal subunit, binds large rRNA. Forms the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

70601:PH RS01595
gene id: 70601:PH_RS01595
uniprot id: O58096
names: Similarity
messages: Belongs to the UPF0216 family.

70601:PH RS08015
gene id: 70601:PH_RS08015
uniprot id: O59361
names: Cofactor
names: Similarity
messages: Belongs to the UPF0292 family.
messages: Binds two Mg(2+) per subunit.

70601:PH RS08065
gene id: 70601:PH_RS08065
uniprot id: O59406
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS08555
gene id: 70601:PH_RS08555
uniprot id: O59479
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).

70601:PH RS03400
gene id: 70601:PH_RS03400
uniprot id: O58451
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

70601:PH RS06060
gene id: 70601:PH_RS06060
uniprot id: O59014
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

70601:PH RS05270
gene id: 70601:PH_RS05270
uniprot id: O58854
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

70601:PH RS00155
gene id: 70601:PH_RS00155
uniprot id: O57753
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

70601:PH RS08425
gene id: 70601:PH_RS08425
uniprot id: O74098
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (By similarity).
messages: Chromosome
messages: Cytoplasm
messages: Homodimer (PubMed:12527306). Dimers then assemble into higher oligomers, with the DNA wrapped around the protein core (By similarity).

70601:PH RS06840
gene id: 70601:PH_RS06840
uniprot id: O59119
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS08915
gene id: 70601:PH_RS08915
uniprot id: O59530
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS05855
gene id: 70601:PH_RS05855
uniprot id: O58938
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

70601:PH RS05275
gene id: 70601:PH_RS05275
uniprot id: O74001
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

70601:PH RS02075
gene id: 70601:PH_RS02075
uniprot id: O58187
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

70601:PH RS06020
gene id: 70601:PH_RS06020
uniprot id: O59023
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the carbamate kinase family.
messages: Cytoplasm
messages: Homodimer.

70601:PH RS08465
gene id: 70601:PH_RS08465
uniprot id: O59456
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

70601:PH RS00795
gene id: 70601:PH_RS00795
uniprot id: O57914
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

70601:PH RS07745
gene id: 70601:PH_RS07745
uniprot id: P62011
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

70601:PH RS05330
gene id: 70601:PH_RS05330
uniprot id: O58865
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

70601:PH RS06990
gene id: 70601:PH_RS06990
uniprot id: O59151
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

70601:PH RS06650
gene id: 70601:PH_RS06650
uniprot id: O50116
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.

70601:PH RS07715
gene id: 70601:PH_RS07715
uniprot id: O59298
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

70601:PH RS06585
gene id: 70601:PH_RS06585
uniprot id: O50097
names: Similarity
messages: Belongs to the UPF0111 family.

70601:PH RS05360
gene id: 70601:PH_RS05360
uniprot id: O58891
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage.

70601:PH RS06015
gene id: 70601:PH_RS06015
uniprot id: O59025
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

70601:PH RS01320
gene id: 70601:PH_RS01320
uniprot id: O58033
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers.

70601:PH RS00570
gene id: 70601:PH_RS00570
uniprot id: O57864
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

70601:PH RS09070
gene id: 70601:PH_RS09070
uniprot id: O59580
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

70601:PH RS00745
gene id: 70601:PH_RS00745
uniprot id: O57903
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm2 family.
messages: This subunit may be involved in monitoring complementarity of crRNA and target RNA.

70601:PH RS08320
gene id: 70601:PH_RS08320
uniprot id: O59432
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

70601:PH RS02805
gene id: 70601:PH_RS02805
uniprot id: O58320
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.
messages: Cytoplasm
messages: Homodimer.

70601:PH RS05155
gene id: 70601:PH_RS05155
uniprot id: O58830
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

70601:PH RS03075
gene id: 70601:PH_RS03075
uniprot id: O73984
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

70601:PH RS02450
gene id: 70601:PH_RS02450
uniprot id: O58264
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

70601:PH RS03730
gene id: 70601:PH_RS03730
uniprot id: O58524
names: Similarity
messages: Belongs to the arginase family.

70601:PH RS06390
gene id: 70601:PH_RS06390
uniprot id: O59072
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

70601:PH RS04920
gene id: 70601:PH_RS04920
uniprot id: O58750
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS09440
gene id: 70601:PH_RS09440
uniprot id: O57706
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.

70601:PH RS09390
gene id: 70601:PH_RS09390
uniprot id: O57716
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

70601:PH RS08380
gene id: 70601:PH_RS08380
uniprot id: O59422
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

70601:PH RS09110
gene id: 70601:PH_RS09110
uniprot id: O59588
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

70601:PH RS00435
gene id: 70601:PH_RS00435
uniprot id: O57832
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS04430
gene id: 70601:PH_RS04430
uniprot id: O58679
names: Function
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-aspartate to produce beta-alanine, and the decarboxylation of L-glutamate to produce 4-aminobutanoate. Can also use cysteate and, to a lesser extent, cysteine sulfite (3-sulfino-L-alanine), but not L-tyrosine. Specific activities toward L-aspartate and cysteate are higher than toward L-glutamate.
messages: Monomer.

70601:PH RS08330
gene id: 70601:PH_RS08330
uniprot id: O59431
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

70601:PH RS08170
gene id: 70601:PH_RS08170
uniprot id: O59384
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

70601:PH RS04465
gene id: 70601:PH_RS04465
uniprot id: O58674
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

70601:PH RS05945
gene id: 70601:PH_RS05945
uniprot id: O74006
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

70601:PH RS09350
gene id: 70601:PH_RS09350
uniprot id: O57726
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

70601:PH RS07000
gene id: 70601:PH_RS07000
uniprot id: O59152
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

70601:PH RS04075
gene id: 70601:PH_RS04075
uniprot id: O58595
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS02570
gene id: 70601:PH_RS02570
uniprot id: O58285
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

70601:PH RS08505
gene id: 70601:PH_RS08505
uniprot id: O59468
names: Similarity
messages: Belongs to the RuvB family.

70601:PH RS07795
gene id: 70601:PH_RS07795
uniprot id: O59350
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

70601:PH RS06570
gene id: 70601:PH_RS06570
uniprot id: O50093
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

70601:PH RS02950
gene id: 70601:PH_RS02950
uniprot id: O58362
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

70601:PH RS05690
gene id: 70601:PH_RS05690
uniprot id: P59734
names: Similarity
messages: Belongs to the UPF0248 family.

70601:PH RS09215
gene id: 70601:PH_RS09215
uniprot id: O59610
names: PTM
names: Similarity
messages: Belongs to the DNA polymerase type-B family.
messages: This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.

70601:PH RS05670
gene id: 70601:PH_RS05670
uniprot id: O58974
names: Similarity
messages: Belongs to the BtpA family.

70601:PH RS09400
gene id: 70601:PH_RS09400
uniprot id: O57713
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0104 family.
messages: Cell membrane

70601:PH RS06615
gene id: 70601:PH_RS06615
uniprot id: O50105
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

70601:PH RS04395
gene id: 70601:PH_RS04395
uniprot id: O58687
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

70601:PH RS05700
gene id: 70601:PH_RS05700
uniprot id: O58969
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Cell membrane
messages: Probably part of a binding-protein-dependent transport system PH1214/15/16.

70601:PH RS07310
gene id: 70601:PH_RS07310
uniprot id: O59226
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

70601:PH RS07705
gene id: 70601:PH_RS07705
uniprot id: P62015
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

70601:PH RS06855
gene id: 70601:PH_RS06855
uniprot id: O59122
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS07075
gene id: 70601:PH_RS07075
uniprot id: P62009
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, box H/ACA, box C/D and box C'/D' sRNAs (By similarity). When added to reconstituted ribonuclease P (RNase P) it increases the optimum temperature to that of the partially purified enzyme and causes a 5-fold increase in apparent Vmax. Binds the RNase P catalytic RNA.
messages: Part of the 50S ribosomal subunit (By similarity). May be part of the RNase P complex. Reconstituted enzyme missing individual protein subunits is suboptimally active, showing each subunit contributes to optimization of activity.

70601:PH RS07360
gene id: 70601:PH_RS07360
uniprot id: O59219
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

70601:PH RS03720
gene id: 70601:PH_RS03720
uniprot id: O58522
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

70601:PH RS07290
gene id: 70601:PH_RS07290
uniprot id: O59228
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

70601:PH RS04550
gene id: 70601:PH_RS04550
uniprot id: O58698
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

70601:PH RS08490
gene id: 70601:PH_RS08490
uniprot id: O59465
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS02480
gene id: 70601:PH_RS02480
uniprot id: O73978
names: Similarity
messages: Belongs to the UPF0440 family.

70601:PH RS00920
gene id: 70601:PH_RS00920
uniprot id: O57943
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

70601:PH RS07255
gene id: 70601:PH_RS07255
uniprot id: O59206
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

70601:PH RS03600
gene id: 70601:PH_RS03600
uniprot id: O58491
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

70601:PH RS07755
gene id: 70601:PH_RS07755
uniprot id: O74021
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

70601:PH RS05055
gene id: 70601:PH_RS05055
uniprot id: O58805
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

70601:PH RS00690
gene id: 70601:PH_RS00690
uniprot id: O57890
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.
messages: Cell membrane
messages: Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Binds tungstate and molybdate (By similarity).
messages: The complex is composed of two ATP-binding proteins (WtpC), two transmembrane proteins (WtpB) and a solute-binding protein (WtpA).

70601:PH RS04405
gene id: 70601:PH_RS04405
uniprot id: O58683
names: Similarity
messages: Belongs to the HerA family.

70601:PH RS05835
gene id: 70601:PH_RS05835
uniprot id: O58941
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.

70601:PH RS07315
gene id: 70601:PH_RS07315
uniprot id: O74019
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

70601:PH RS03480
gene id: 70601:PH_RS03480
uniprot id: O58470
names: Similarity
messages: Belongs to the HypE family.

70601:PH RS03310
gene id: 70601:PH_RS03310
uniprot id: O58433
names: Function
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

70601:PH RS02900
gene id: 70601:PH_RS02900
uniprot id: O58353
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

70601:PH RS03580
gene id: 70601:PH_RS03580
uniprot id: O58495
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

70601:PH RS05010
gene id: 70601:PH_RS05010
uniprot id: O58792
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

70601:PH RS07555
gene id: 70601:PH_RS07555
uniprot id: O59251
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

70601:PH RS02440
gene id: 70601:PH_RS02440
uniprot id: O58263
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity).

70601:PH RS03185
gene id: 70601:PH_RS03185
uniprot id: O58413
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

70601:PH RS07085
gene id: 70601:PH_RS07085
uniprot id: O59167
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

70601:PH RS02945
gene id: 70601:PH_RS02945
uniprot id: O58361
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Homohexamer.

70601:PH RS00785
gene id: 70601:PH_RS00785
uniprot id: O57912
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

70601:PH RS05300
gene id: 70601:PH_RS05300
uniprot id: O58858
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

70601:PH RS08070
gene id: 70601:PH_RS08070
uniprot id: O59405
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS03205
gene id: 70601:PH_RS03205
uniprot id: O58417
names: Cofactor
names: Subunit
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

70601:PH RS00825
gene id: 70601:PH_RS00825
uniprot id: O57921
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

70601:PH RS09250
gene id: 70601:PH_RS09250
uniprot id: O59619
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

70601:PH RS07515
gene id: 70601:PH_RS07515
uniprot id: O59258
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.

70601:PH RS08040
gene id: 70601:PH_RS08040
uniprot id: O59413
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C56 family.
messages: Cytoplasm
messages: Deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage (By similarity). Also displays proteolytic activity (PubMed:11114201).
messages: Homohexamer formed by a dimer of trimers that assemble into a hollow ring structure.

70601:PH RS01615
gene id: 70601:PH_RS01615
uniprot id: O58099
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS05955
gene id: 70601:PH_RS05955
uniprot id: P59937
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

70601:PH RS04880
gene id: 70601:PH_RS04880
uniprot id: O58759
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Probably part of a binding-protein-dependent transport system PH1036/38/39. Probably responsible for the translocation of the substrate across the membrane.

70601:PH RS03555
gene id: 70601:PH_RS03555
uniprot id: O58499
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane

70601:PH RS08025
gene id: 70601:PH_RS08025
uniprot id: O74092
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (By similarity).
messages: Chromosome
messages: Cytoplasm
messages: Homodimer or heterodimer with another histone. Dimers then assemble into higher oligomers, with the DNA wrapped around the protein core (By similarity).

70601:PH RS02920
gene id: 70601:PH_RS02920
uniprot id: O58356
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Binds two Mg(2+) per subunit.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

70601:PH RS02340
gene id: 70601:PH_RS02340
uniprot id: O58237
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

70601:PH RS07500
gene id: 70601:PH_RS07500
uniprot id: O59261
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

70601:PH RS08325
gene id: 70601:PH_RS08325
uniprot id: P62013
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

70601:PH RS03570
gene id: 70601:PH_RS03570
uniprot id: O58497
names: Function
names: Similarity
messages: Belongs to the Tfx family.
messages: Putative transcriptional regulator.

70601:PH RS01400
gene id: 70601:PH_RS01400
uniprot id: O58050
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm

70601:PH RS09425
gene id: 70601:PH_RS09425
uniprot id: O57708
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

70601:PH RS08630
gene id: 70601:PH_RS08630
uniprot id: O74099
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

70601:PH RS06590
gene id: 70601:PH_RS06590
uniprot id: O50098
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NAD(P)H-dependent reduction of ketopantoate into pantoic acid.
messages: Cytoplasm

70601:PH RS08270
gene id: 70601:PH_RS08270
uniprot id: O59444
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS03130
gene id: 70601:PH_RS03130
uniprot id: O58403
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the aspartate/glutamate racemases family.
messages: Homodimer. The existence of the interchain disulfide bond seen in the crystal structures is uncertain, but disulfide bonds have been reported for cytoplasmic proteins from thermophiles.
messages: Weakly inhibited by citrate, but not by asparagine.

70601:PH RS03470
gene id: 70601:PH_RS03470
uniprot id: O58468
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

70601:PH RS07405
gene id: 70601:PH_RS07405
uniprot id: O74020
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

70601:PH RS03945
gene id: 70601:PH_RS03945
uniprot id: O58565
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

70601:PH RS07695
gene id: 70601:PH_RS07695
uniprot id: O59295
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

70601:PH RS00100
gene id: 70601:PH_RS00100
uniprot id: O57762
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Forms an oligomeric complex of eight-membered rings.
messages: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

70601:PH RS00800
gene id: 70601:PH_RS00800
uniprot id: O57915
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

70601:PH RS01335
gene id: 70601:PH_RS01335
uniprot id: O58035
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Edits incorrectly charged Ser-tRNA(Ala). Incorrectly charged amino acids occur because the of inherent physicochemical limitations on discrimination between closely related amino acids (Gly and Ser) in the charging step.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs (By similarity).
messages: Cytoplasm
messages: Homodimer.
messages: Unlike the case in Archaeoglobus fulgidus and some of the free-standing tRNA(Ala) AlaX editing proteins, His-721 does not bind zinc but forms a hydrogen bond with Cys-717 instead.

70601:PH RS04490
gene id: 70601:PH_RS04490
uniprot id: O58669
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-64 and Arg-67) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.

70601:PH RS03065
gene id: 70601:PH_RS03065
uniprot id: O58388
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS00530
gene id: 70601:PH_RS00530
uniprot id: O57854
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.

70601:PH RS02330
gene id: 70601:PH_RS02330
uniprot id: O58236
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PINc/VapC protein family.
messages: Homodimer.
messages: Toxic component of a type II toxin-antitoxin (TA) system. An RNase.

70601:PH RS02965
gene id: 70601:PH_RS02965
uniprot id: O58366
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS08300
gene id: 70601:PH_RS08300
uniprot id: O59438
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

70601:PH RS03405
gene id: 70601:PH_RS03405
uniprot id: O58452
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

70601:PH RS04860
gene id: 70601:PH_RS04860
uniprot id: O58764
names: Similarity
messages: Belongs to the UPF0310 family.

70601:PH RS06330
gene id: 70601:PH_RS06330
uniprot id: O59060
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

70601:PH RS07230
gene id: 70601:PH_RS07230
uniprot id: O59200
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS08540
gene id: 70601:PH_RS08540
uniprot id: O59475
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

70601:PH RS00610
gene id: 70601:PH_RS00610
uniprot id: O57872
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).

70601:PH RS08130
gene id: 70601:PH_RS08130
uniprot id: O59391
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

70601:PH RS06660
gene id: 70601:PH_RS06660
uniprot id: O50118
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

70601:PH RS03520
gene id: 70601:PH_RS03520
uniprot id: O58509
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

70601:PH RS07725
gene id: 70601:PH_RS07725
uniprot id: O59300
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

70601:PH RS00890
gene id: 70601:PH_RS00890
uniprot id: O57935
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

70601:PH RS06425
gene id: 70601:PH_RS06425
uniprot id: O59080
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: Homohexamer. In the presence of PdxT, forms a dodecamer of heterodimers.

70601:PH RS07730
gene id: 70601:PH_RS07730
uniprot id: O59302
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

70601:PH RS06665
gene id: 70601:PH_RS06665
uniprot id: O50119
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

70601:PH RS08560
gene id: 70601:PH_RS08560
uniprot id: O59480
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

70601:PH RS05435
gene id: 70601:PH_RS05435
uniprot id: O58875
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

70601:PH RS00145
gene id: 70601:PH_RS00145
uniprot id: P58748
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

70601:PH RS06745
gene id: 70601:PH_RS06745
uniprot id: O59098
names: Similarity
messages: Belongs to the UPF0091 family.

70601:PH RS06005
gene id: 70601:PH_RS06005
uniprot id: O59028
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH2/MDH2 oxidoreductase family.
messages: Cytoplasm
messages: Homodimer.

70601:PH RS01295
gene id: 70601:PH_RS01295
uniprot id: O58027
names: Similarity
messages: Belongs to the GbsR family.

70601:PH RS08675
gene id: 70601:PH_RS08675
uniprot id: O59517
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

70601:PH RS04375
gene id: 70601:PH_RS04375
uniprot id: O58690
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. MPGP family.
messages: Cytoplasm
messages: Hydrolyzes mannosyl-3-phosphoglycerate (MPG) to form the osmolyte mannosylglycerate (MG). The enzyme is absolutely specific for MPG.

70601:PH RS07300
gene id: 70601:PH_RS07300
uniprot id: O93777
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

70601:PH RS04725
gene id: 70601:PH_RS04725
uniprot id: O58730
names: Similarity
messages: Belongs to the UPF0282 family.

70601:PH RS07340
gene id: 70601:PH_RS07340
uniprot id: O59224
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

70601:PH RS09365
gene id: 70601:PH_RS09365
uniprot id: O57721
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

70601:PH RS09240
gene id: 70601:PH_RS09240
uniprot id: O59621
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

70601:PH RS07415
gene id: 70601:PH_RS07415
uniprot id: O59281
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

70601:PH RS00725
gene id: 70601:PH_RS00725
uniprot id: O57898
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane
messages: Probable biotin transporter.

70601:PH RS05900
gene id: 70601:PH_RS05900
uniprot id: O58998
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

70601:PH RS07605
gene id: 70601:PH_RS07605
uniprot id: O59240
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

70601:PH RS04955
gene id: 70601:PH_RS04955
uniprot id: O58783
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

70601:PH RS08105
gene id: 70601:PH_RS08105
uniprot id: O59397
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways.

70601:PH RS06310
gene id: 70601:PH_RS06310
uniprot id: O59038
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

70601:PH RS09190
gene id: 70601:PH_RS09190
uniprot id: O59603
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

70601:PH RS05715
gene id: 70601:PH_RS05715
uniprot id: O58966
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
messages: Up-regulated by exposure to oxygen (at protein level).

70601:PH RS01405
gene id: 70601:PH_RS01405
uniprot id: O58052
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

70601:PH RS07505
gene id: 70601:PH_RS07505
uniprot id: O59260
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

70601:PH RS03090
gene id: 70601:PH_RS03090
uniprot id: O58394
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

70601:PH RS02820
gene id: 70601:PH_RS02820
uniprot id: O58316
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

70601:PH RS03290
gene id: 70601:PH_RS03290
uniprot id: O58429
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

70601:PH RS00810
gene id: 70601:PH_RS00810
uniprot id: O57917
names: Similarity
messages: Belongs to the glutaredoxin family.

70601:PH RS05105
gene id: 70601:PH_RS05105
uniprot id: O58816
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal MetE family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown.

70601:PH RS07220
gene id: 70601:PH_RS07220
uniprot id: O59198
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
messages: Cytoplasm

70601:PH RS07070
gene id: 70601:PH_RS07070
uniprot id: P61030
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

70601:PH RS09260
gene id: 70601:PH_RS09260
uniprot id: O59618
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal-type GPI family.
messages: Binds 1 Fe cation per subunit.
messages: Cytoplasm
messages: Homodimer.

70601:PH RS03540
gene id: 70601:PH_RS03540
uniprot id: O58504
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS01440
gene id: 70601:PH_RS01440
uniprot id: O58056
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

70601:PH RS02155
gene id: 70601:PH_RS02155
uniprot id: O58216
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

70601:PH RS01120
gene id: 70601:PH_RS01120
uniprot id: O57983
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

70601:PH RS08295
gene id: 70601:PH_RS08295
uniprot id: O59439
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

70601:PH RS03705
gene id: 70601:PH_RS03705
uniprot id: O58518
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

70601:PH RS05655
gene id: 70601:PH_RS05655
uniprot id: O58977
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS08310
gene id: 70601:PH_RS08310
uniprot id: O59435
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

70601:PH RS00350
gene id: 70601:PH_RS00350
uniprot id: O57792
names: Similarity
messages: Belongs to the UPF0215 family.

70601:PH RS07525
gene id: 70601:PH_RS07525
uniprot id: O59256
names: Function
names: Subunit
messages: DNA-binding protein that negatively regulates its own transcription. Interferes with RNA polymerase (RNAP) recruitment by inhibiting the association of RNAP with the TBP-TFB promoter complex.
messages: Homooctamer; tetramer of dimers.

70601:PH RS03110
gene id: 70601:PH_RS03110
uniprot id: O58398
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

70601:PH RS07630
gene id: 70601:PH_RS07630
uniprot id: O59235
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm

70601:PH RS00650
gene id: 70601:PH_RS00650
uniprot id: O57887
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

70601:PH RS03140
gene id: 70601:PH_RS03140
uniprot id: O58405
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0252 family.
messages: Cell membrane

70601:PH RS03775
gene id: 70601:PH_RS03775
uniprot id: O58533
names: Similarity
messages: Belongs to the UPF0251 family.

70601:PH RS03510
gene id: 70601:PH_RS03510
uniprot id: O58512
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

70601:PH RS05740
gene id: 70601:PH_RS05740
uniprot id: O58960
names: Similarity
messages: Belongs to the ZPR1 family.

70601:PH RS03735
gene id: 70601:PH_RS03735
uniprot id: O58525
names: Similarity
messages: Belongs to the UPF0148 family.

70601:PH RS07175
gene id: 70601:PH_RS07175
uniprot id: O74016
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

70601:PH RS02165
gene id: 70601:PH_RS02165
uniprot id: O58214
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

70601:PH RS01630
gene id: 70601:PH_RS01630
uniprot id: O58104
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

70601:PH RS00555
gene id: 70601:PH_RS00555
uniprot id: O57860
names: Similarity
messages: Belongs to the UPF0173 family.

70601:PH RS02525
gene id: 70601:PH_RS02525
uniprot id: O58275
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

70601:PH RS08375
gene id: 70601:PH_RS08375
uniprot id: O59423
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

70601:PH RS03725
gene id: 70601:PH_RS03725
uniprot id: O58523
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

70601:PH RS07265
gene id: 70601:PH_RS07265
uniprot id: O59207
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

70601:PH RS00025
gene id: 70601:PH_RS00025
uniprot id: O57776
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

70601:PH RS08125
gene id: 70601:PH_RS08125
uniprot id: O59393
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

70601:PH RS04750
gene id: 70601:PH_RS04750
uniprot id: O58736
names: Similarity
messages: Belongs to the UPF0200 family.

70601:PH RS07750
gene id: 70601:PH_RS07750
uniprot id: O59306
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

70601:PH RS07670
gene id: 70601:PH_RS07670
uniprot id: O59288
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

70601:PH RS01625
gene id: 70601:PH_RS01625
uniprot id: O58103
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

70601:PH RS06975
gene id: 70601:PH_RS06975
uniprot id: O59147
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

70601:PH RS08600
gene id: 70601:PH_RS08600
uniprot id: O59488
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

70601:PH RS02135
gene id: 70601:PH_RS02135
uniprot id: O58221
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively (By similarity).
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity (By similarity).
messages: This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.

70601:PH RS02300
gene id: 70601:PH_RS02300
uniprot id: O58227
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

70601:PH RS09345
gene id: 70601:PH_RS09345
uniprot id: O57727
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

70601:PH RS02350
gene id: 70601:PH_RS02350
uniprot id: O58239
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

70601:PH RS03435
gene id: 70601:PH_RS03435
uniprot id: O58459
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

70601:PH RS02855
gene id: 70601:PH_RS02855
uniprot id: O58310
names: Similarity
messages: Belongs to the MCM family.

70601:PH RS07105
gene id: 70601:PH_RS07105
uniprot id: O59172
names: Similarity
messages: Belongs to the UPF0166 family.

70601:PH RS00245
gene id: 70601:PH_RS00245
uniprot id: O57811
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

70601:PH RS01275
gene id: 70601:PH_RS01275
uniprot id: O58022
names: Similarity
messages: Belongs to the UPF0273 family.

70601:PH RS05375
gene id: 70601:PH_RS05375
uniprot id: O58888
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

70601:PH RS00885
gene id: 70601:PH_RS00885
uniprot id: O57934
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: The bound zinc ion is not a cofactor. It is bound to a zinc knuckle motif that may be involved in sequence recognition and the binding of ssDNA (PubMed:14750947).

70601:PH RS00870
gene id: 70601:PH_RS00870
uniprot id: O57930
names: Subunit
messages: Homotetramer.

70601:PH RS08545
gene id: 70601:PH_RS08545
uniprot id: O59476
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

70601:PH RS06705
gene id: 70601:PH_RS06705
uniprot id: O50128
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

70601:PH RS05450
gene id: 70601:PH_RS05450
uniprot id: O58872
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

70601:PH RS04240
gene id: 70601:PH_RS04240
uniprot id: O58636
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

70601:PH RS09185
gene id: 70601:PH_RS09185
uniprot id: P58078
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

70601:PH RS02685
gene id: 70601:PH_RS02685
uniprot id: O58307
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Editing domain AlaX-S subfamily.
messages: Binds 1 zinc ion per subunit; the homodimer seems not to bind zinc. The zinc is probably not catalytic (PubMed:16087889). Another report suggests the zinc is catalytic (PubMed:16374837).
messages: Cytoplasm
messages: Functions in trans to edit the amino acid moiety from mischarged charged Ser-tRNA(Ala). Has little activity against Gly-tRNA(Ala).
messages: Monomer and homodimer; the dimer is less active in tRNA editing and does not have a zinc ion associated with it (PubMed:16087889). Another report shows only a monomeric form (PubMed:16374837).

70601:PH RS06085
gene id: 70601:PH_RS06085
uniprot id: O59010
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Cell membrane
messages: Contains eight transmembrane regions plus two helical hairpins that dip into the membrane. These helical hairpin structures play an important role in the transport process. The first enters the membrane from the cytoplasmic side, the second one from the extracellular side. During the transport cycle, the regions involved in amino acid transport, and especially the helical hairpins, move vertically by about 15-18 Angstroms, alternating between exposure to the aqueous phase and reinsertion in the lipid bilayer. In contrast, regions involved in trimerization do not move.
messages: Homotrimer.
messages: Sodium-dependent, high-affinity amino acid transporter that mediates aspartate uptake (PubMed:17435767, PubMed:19380583, PubMed:17230192, Ref.11). Has only very low glutamate transport activity (PubMed:19380583, PubMed:17230192). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions, resulting in electrogenic transport (PubMed:17435767, PubMed:19380583, Ref.11). Na(+) binding enhances the affinity for aspartate (PubMed:19380583, Ref.11). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:17435767). In contrast to mammalian homologs, transport does not depend on pH or K(+) ions (PubMed:19380583).

70601:PH RS02410
gene id: 70601:PH_RS02410
uniprot id: O58256
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

70601:PH RS00080
gene id: 70601:PH_RS00080
uniprot id: O57767
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Contains three domains displaying pseudo-three-fold symmetry that each contribute a cysteine residue for ligation to a centrally located [4Fe-4S] cluster.
messages: Cytoplasm
messages: Monomer (PubMed:15937336). Homodimer (PubMed:27224840).

70601:PH RS04475
gene id: 70601:PH_RS04475
uniprot id: O58672
names: Similarity
messages: Belongs to the UPF0091 family.

70601:PH RS04685
gene id: 70601:PH_RS04685
uniprot id: O58721
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

70601:PH RS04370
gene id: 70601:PH_RS04370
uniprot id: O58649
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

70601:PH RS08280
gene id: 70601:PH_RS08280
uniprot id: O59442
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

70601:PH RS08345
gene id: 70601:PH_RS08345
uniprot id: O59427
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

70601:PH RS09380
gene id: 70601:PH_RS09380
uniprot id: O57718
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

70601:PH RS04150
gene id: 70601:PH_RS04150
uniprot id: O58609
names: Similarity
messages: Belongs to the HypD family.

70601:PH RS00925
gene id: 70601:PH_RS00925
uniprot id: O57944
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

70601:PH RS07350
gene id: 70601:PH_RS07350
uniprot id: O59221
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

70601:PH RS07675
gene id: 70601:PH_RS07675
uniprot id: O59289
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

70601:PH RS06290
gene id: 70601:PH_RS06290
uniprot id: O59041
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

70601:PH RS00590
gene id: 70601:PH_RS00590
uniprot id: O57868
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

70601:PH RS01110
gene id: 70601:PH_RS01110
uniprot id: O57981
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

70601:PH RS04620
gene id: 70601:PH_RS04620
uniprot id: O58708
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

70601:PH RS02175
gene id: 70601:PH_RS02175
uniprot id: O58212
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.
messages: Catalyzes the hydrolysis of S-adenosyl-L-methionine (SAM) into adenosine and L-methionine (PubMed:18551689). Is likely stereoselective, specifically hydrolyzing (R)-S-adenosyl-L-methionine ((R)-SAM), the inactive form of the ubiquitous cofactor SAM, and not the active form of SAM, (S)-S-adenosyl-L-methionine (By similarity). Probaly plays a role in preventing accumulation of (R)-S-adenosyl-L-methionine in cells; maintenance of (S)-S-denosyl-L-methionine homochirality is important for cellular health given that the (R)-form is largely inactive as a methyl donor and can function as an inhibitor of methyltransferases (By similarity). Is unable to mediate a fluorination or chlorination reaction with SAM (PubMed:18551689).
messages: Homotrimer.

70601:PH RS01230
gene id: 70601:PH_RS01230
uniprot id: O58012
names: Function
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.
messages: May have GTPase activity. May also bind and hydrolyze ATP. May function as chaperone (By similarity).

70601:PH RS06575
gene id: 70601:PH_RS06575
uniprot id: O50094
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

70601:PH RS04470
gene id: 70601:PH_RS04470
uniprot id: O58673
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

70601:PH RS04535
gene id: 70601:PH_RS04535
uniprot id: O58655
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

70601:PH RS04025
gene id: 70601:PH_RS04025
uniprot id: O58586
names: Similarity
messages: Belongs to the flavoredoxin family.

70601:PH RS02145
gene id: 70601:PH_RS02145
uniprot id: O58218
names: Similarity
messages: Belongs to the AOR/FOR family.

70601:PH RS02180
gene id: 70601:PH_RS02180
uniprot id: O58211
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

70601:PH RS03910
gene id: 70601:PH_RS03910
uniprot id: O58558
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Putative gamma-glutamylcyclotransferase.

70601:PH RS00310
gene id: 70601:PH_RS00310
uniprot id: O57798
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

70601:PH RS05905
gene id: 70601:PH_RS05905
uniprot id: O58997
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane

70601:PH RS09200
gene id: 70601:PH_RS09200
uniprot id: O59605
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

70601:PH RS07940
gene id: 70601:PH_RS07940
uniprot id: O59317
names: Similarity
messages: Belongs to the class-I fumarase family.

70601:PH RS07065
gene id: 70601:PH_RS07065
uniprot id: P61124
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

70601:PH RS00415
gene id: 70601:PH_RS00415
uniprot id: O57836
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

70601:PH RS00405
gene id: 70601:PH_RS00405
uniprot id: O57839
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the arginase family. Agmatinase subfamily.
messages: Binds 2 divalent metal cations per subunit (By similarity). Co(2+) is the most effection cation. Can also use Ca(2+), Mn(2+), Zn(2+) or Mg(2+) (PubMed:15752699).
messages: Catalyzes the formation of putrescine from agmatine. Cannot use arginine.
messages: Homotetramer.
messages: Inhibited by putrescine. Activity is not affected by arginine and ornithine.

70601:PH RS03340
gene id: 70601:PH_RS03340
uniprot id: O58440
names: Cofactor
names: Domain
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Binds 1 zinc ion per subunit.
messages: Has 2 structurally independent domains; the N-terminal PINc domain which binds Mn(2+), rRNA substrate and probably has endoribonuclease activity, and the C-terminal zinc ribbon domain which also binds rRNA substrate.
messages: Manganese; magnesium does not support nuclease activity.
messages: Toxic component of a type II toxin-antitoxin (TA) system (Potential). Processes pre-16S-rRNA at its 3' end (the D-site) to yield the mature 3' end.

70601:PH RS02560
gene id: 70601:PH_RS02560
uniprot id: O58283
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

70601:PH RS07805
gene id: 70601:PH_RS07805
uniprot id: O59347
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

70601:PH RS09165
gene id: 70601:PH_RS09165
uniprot id: O59599
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

70601:PH RS07345
gene id: 70601:PH_RS07345
uniprot id: O59223
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteromeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

70601:PH RS02530
gene id: 70601:PH_RS02530
uniprot id: O58276
names: Similarity
messages: Belongs to the archaeal ATPase family.

70601:PH RS03685
gene id: 70601:PH_RS03685
uniprot id: O58474
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS02970
gene id: 70601:PH_RS02970
uniprot id: O58367
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

70601:PH RS03530
gene id: 70601:PH_RS03530
uniprot id: O58506
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

70601:PH RS05805
gene id: 70601:PH_RS05805
uniprot id: O58947
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

70601:PH RS08615
gene id: 70601:PH_RS08615
uniprot id: O59491
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

70601:PH RS08150
gene id: 70601:PH_RS08150
uniprot id: O59386
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

70601:PH RS00210
gene id: 70601:PH_RS00210
uniprot id: O57820
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

70601:PH RS02980
gene id: 70601:PH_RS02980
uniprot id: O58369
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

70601:PH RS00750
gene id: 70601:PH_RS00750
uniprot id: O57904
names: Similarity
messages: Belongs to the CRISPR-associated Csm3 family.

70601:PH RS08905
gene id: 70601:PH_RS08905
uniprot id: O59533
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

70601:PH RS03560
gene id: 70601:PH_RS03560
uniprot id: O58498
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

70601:PH RS05890
gene id: 70601:PH_RS05890
uniprot id: O58930
names: Similarity
messages: Belongs to the NodU/CmcH family.

70601:PH RS03460
gene id: 70601:PH_RS03460
uniprot id: O58466
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

70601:PH RS03345
gene id: 70601:PH_RS03345
uniprot id: O58441
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

70601:PH RS02880
gene id: 70601:PH_RS02880
uniprot id: O58348
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS08385
gene id: 70601:PH_RS08385
uniprot id: O59421
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

70601:PH RS00975
gene id: 70601:PH_RS00975
uniprot id: O57953
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane

70601:PH RS08485
gene id: 70601:PH_RS08485
uniprot id: O59462
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

70601:PH RS07445
gene id: 70601:PH_RS07445
uniprot id: O59272
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Similarity
messages: Activity is strongly promoted by Co(2+), Ni(2+), Mg(2+), Mn(2+), Ca(2+), Zn(2+) and Cu(2+) (PubMed:27322068). Activity is inhibited by EDTA (PubMed:27322068).
messages: Belongs to the damage-control phosphatase family. Nucleotides phosphatase I subfamily.
messages: Metal-dependent phosphatase with probable damage-control functions (PubMed:27322068). Shows phosphatase activity against p-nitrophenyl phosphate (pNPP), but natural substrates have not been identified yet (PubMed:27322068). Low phosphatase activity against 8-oxo nucleotides suggests that it could hydrolyze oxidatively damaged purine nucleotides or their biosynthetic intermediates (PubMed:27322068).
messages: Phosphatase activity is strongly promoted by several divalent cation ions but it is suggested that Mn(2+) and possibly Ni(2+) represent biologically relevant metal ion cofactors for damage-control phosphatase activity (PubMed:27322068).
messages: Subfamily I proteins are distinguished by three conserved motifs: the CxxC motif localized near the N-terminus, the GNFE motif localized about 40 residues from the C-terminus, and the KC motif localized about 25 residues from the C-terminus (Probable). In the crystal structures of the subfamily I proteins, the side chains of the cysteines in the CxxC and KC motifs face each other across the rim of the putative substrate-binding cleft, and the GNFE motif lies deep in the cleft close to the metal-binding aspartate and asparagine (Probable). the 3 conserved cysteines in motifs CxxC and KC play a key role in the interaction with the Fe-containing chromophore, which is not directly involved in catalysis (Probable).
messages: The [2Fe-2S] cluster does not seem to be directly involved in catalysis (PubMed:27322068).

70601:PH RS02400
gene id: 70601:PH_RS02400
uniprot id: O58254
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

70601:PH RS06760
gene id: 70601:PH_RS06760
uniprot id: O59099
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

70601:PH RS00560
gene id: 70601:PH_RS00560
uniprot id: O57861
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).
messages: This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.

70601:PH RS05035
gene id: 70601:PH_RS05035
uniprot id: O58799
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

70601:PH RS06030
gene id: 70601:PH_RS06030
uniprot id: O59022
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

70601:PH RS07470
gene id: 70601:PH_RS07470
uniprot id: O59267
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

70601:PH RS03710
gene id: 70601:PH_RS03710
uniprot id: O58520
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

70601:PH RS01470
gene id: 70601:PH_RS01470
uniprot id: O58063
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS00200
gene id: 70601:PH_RS00200
uniprot id: P57671
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

70601:PH RS05200
gene id: 70601:PH_RS05200
uniprot id: O58839
names: Similarity
messages: Belongs to the UPF0127 family.

70601:PH RS06165
gene id: 70601:PH_RS06165
uniprot id: P62007
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

70601:PH RS09180
gene id: 70601:PH_RS09180
uniprot id: O59602
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde.
messages: The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit (By similarity).

70601:PH RS08275
gene id: 70601:PH_RS08275
uniprot id: O59443
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

70601:PH RS04365
gene id: 70601:PH_RS04365
uniprot id: O58651
names: Similarity
messages: Belongs to the phosphohexose mutase family.

70601:PH RS09030
gene id: 70601:PH_RS09030
uniprot id: O59572
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

70601:PH RS03100
gene id: 70601:PH_RS03100
uniprot id: O58397
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

70601:PH RS00945
gene id: 70601:PH_RS00945
uniprot id: O57948
names: Similarity
messages: Belongs to the UPF0146 family.

70601:PH RS04485
gene id: 70601:PH_RS04485
uniprot id: O58670
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

70601:PH RS01560
gene id: 70601:PH_RS01560
uniprot id: O58088
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA), also called psiRNA (prokaryotic silencing) in this organism (Potential).
messages: Monomer; homodimer when crystallized in the presence of crRNA. Varying the crRNA sequence varies degree of oligomerization and structure.
messages: No in vitro nuclease activity has been observed against crRNA for this protein.

70601:PH RS04010
gene id: 70601:PH_RS04010
uniprot id: O58582
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site (By similarity).

70601:PH RS09090
gene id: 70601:PH_RS09090
uniprot id: O59584
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

70601:PH RS04865
gene id: 70601:PH_RS04865
uniprot id: O58763
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

70601:PH RS09300
gene id: 70601:PH_RS09300
uniprot id: O57738
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

70601:PH RS02275
gene id: 70601:PH_RS02275
uniprot id: O58192
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

70601:PH RS03765
gene id: 70601:PH_RS03765
uniprot id: O58530
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Binds two Mg(2+) per subunit.
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain (By similarity).
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity).
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.
messages: This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.

70601:PH RS04185
gene id: 70601:PH_RS04185
uniprot id: O58647
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

70601:PH RS06645
gene id: 70601:PH_RS06645
uniprot id: O50114
names: Similarity
messages: Belongs to the threonine synthase family.

70601:PH RS05720
gene id: 70601:PH_RS05720
uniprot id: O58965
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Homodimer.

70601:PH RS04810
gene id: 70601:PH_RS04810
uniprot id: O58776
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.

70601:PH RS02850
gene id: 70601:PH_RS02850
uniprot id: O58312
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

70601:PH RS06635
gene id: 70601:PH_RS06635
uniprot id: O50110
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

70601:PH RS06550
gene id: 70601:PH_RS06550
uniprot id: O50089
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

70601:PH RS08495
gene id: 70601:PH_RS08495
uniprot id: O59466
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS07005
gene id: 70601:PH_RS07005
uniprot id: O59153
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

70601:PH RS05675
gene id: 70601:PH_RS05675
uniprot id: O58973
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

70601:PH RS00400
gene id: 70601:PH_RS00400
uniprot id: O57840
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by citrate.
messages: Belongs to the DeoC/FbaB aldolase family.
messages: Cytoplasm
messages: Homooctamer.

70601:PH RS05710
gene id: 70601:PH_RS05710
uniprot id: O58967
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Probably part of a binding-protein-dependent transport system PH1214/15/16. Probably responsible for the translocation of the substrate across the membrane.

70601:PH RS04855
gene id: 70601:PH_RS04855
uniprot id: O58765
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

70601:PH RS01375
gene id: 70601:PH_RS01375
uniprot id: O58045
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

70601:PH RS03845
gene id: 70601:PH_RS03845
uniprot id: O58546
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS01685
gene id: 70601:PH_RS01685
uniprot id: O58114
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.

70601:PH RS05430
gene id: 70601:PH_RS05430
uniprot id: O58877
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

70601:PH RS08710
gene id: 70601:PH_RS08710
uniprot id: O59509
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS02475
gene id: 70601:PH_RS02475
uniprot id: O58268
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity).

70601:PH RS08335
gene id: 70601:PH_RS08335
uniprot id: O59430
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

70601:PH RS08120
gene id: 70601:PH_RS08120
uniprot id: O59394
names: Function
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Catalyzes the NAD(+)-dependent oxidative decarboxylation of homoisocitrate to 2-oxoadipate (alpha-ketoadipate), and of isocitrate to 2-oxoglutarate, at near equal efficiency. May thus play a dual role in glutamate and lysine biosynthesis in vivo. Preferentially uses NAD over NADP.

70601:PH RS06735
gene id: 70601:PH_RS06735
uniprot id: O59097
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

70601:PH RS07130
gene id: 70601:PH_RS07130
uniprot id: O59179
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Homodimer.
messages: Inhibited by divalent metal cations, including Mg(2+), Mn(2+), Ca(2+) and Zn(2+). Mildly inhibited by 0.01 % SDS and 0.1% dodecyl-beta-D-maltoside. Activity is nearly abolished by 1 % SDS.
messages: Membrane
messages: Protease that cleaves its substrates preferentially near hydrophobic or aromatic amino acid residues. Can degrade casein and the stomatin homolog PH1511 (in vitro).

70601:PH RS03295
gene id: 70601:PH_RS03295
uniprot id: O58430
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.
messages: The N-terminal domain is an archaea-specific tRNA-editing domain that hydrolyzes incorrectly charged L-seryl-tRNA(Thr). Catalysis of tRNA editing is performed by the charged tRNA itself.

70601:PH RS07775
gene id: 70601:PH_RS07775
uniprot id: O59355
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

70601:PH RS09050
gene id: 70601:PH_RS09050
uniprot id: O59575
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

70601:PH RS00480
gene id: 70601:PH_RS00480
uniprot id: O57823
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

70601:PH RS08365
gene id: 70601:PH_RS08365
uniprot id: O74094
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

70601:PH RS09330
gene id: 70601:PH_RS09330
uniprot id: O57731
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

70601:PH RS00720
gene id: 70601:PH_RS00720
uniprot id: O57896
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family.
messages: Cell membrane
messages: Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (WtpC), two transmembrane proteins (WtpB) and a solute-binding protein (WtpA).

70601:PH RS00010
gene id: 70601:PH_RS00010
uniprot id: O57779
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

70601:PH RS08680
gene id: 70601:PH_RS08680
uniprot id: O74101
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

70601:PH RS08750
gene id: 70601:PH_RS08750
uniprot id: O59500
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

70601:PH RS01765
gene id: 70601:PH_RS01765
uniprot id: O58127
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS06480
gene id: 70601:PH_RS06480
uniprot id: O59090
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS08290
gene id: 70601:PH_RS08290
uniprot id: O59440
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

70601:PH RS06870
gene id: 70601:PH_RS06870
uniprot id: O59124
names: Similarity
messages: Belongs to the UPF0091 family.

70601:PH RS03080
gene id: 70601:PH_RS03080
uniprot id: O58391
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

70601:PH RS07355
gene id: 70601:PH_RS07355
uniprot id: O59220
names: Similarity
messages: Belongs to the SDO1/SBDS family.

70601:PH RS06595
gene id: 70601:PH_RS06595
uniprot id: O50099
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

70601:PH RS09035
gene id: 70601:PH_RS09035
uniprot id: P58746
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

70601:PH RS05985
gene id: 70601:PH_RS05985
uniprot id: O58981
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Cell membrane
messages: Despite low primary sequence conservation between eukaryotic catalytic subunits and bacterial and archaeal single subunit OSTs (ssOST), structural comparison revealed several common motifs at spatially equivalent positions, like the DXD motif 1 on the external loop 1 and the DXD motif 2 on the external loop 2 involved in binding of the metal ion cofactor and the carboxamide group of the acceptor asparagine, the conserved Glu residue of the TIXE/SVSE motif on the external loop 5 involved in catalysis, as well as the WWDYG and the DK/MI motifs in the globular domain that define the binding pocket for the +2 Ser/Thr of the acceptor sequon. In bacterial ssOSTs, an Arg residue was found to interact with a negatively charged side chain at the -2 position of the sequon. This Arg is conserved in bacterial enzymes and correlates with an extended sequon requirement (Asp-X-Asn-X-Ser/Thr) for bacterial N-glycosylation.
messages: Oligosaccharyl transferase (OST) that catalyzes the initial transfer of a defined glycan (ManNAcXyl(2)GlcAMan(2)GalNAc in Pyrococcus) from the lipid carrier dolichol-monophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.

70601:PH RS03450
gene id: 70601:PH_RS03450
uniprot id: O58462
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

70601:PH RS06420
gene id: 70601:PH_RS06420
uniprot id: O59079
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

70601:PH RS04805
gene id: 70601:PH_RS04805
uniprot id: O58778
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the AOR/FOR family.
messages: Binds 1 W-bis(molybdopterin guanine dinucleotide) (W-bis-MGD) cofactor per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Homodimer.

70601:PH RS00875
gene id: 70601:PH_RS00875
uniprot id: O57932
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

70601:PH RS01345
gene id: 70601:PH_RS01345
uniprot id: O58038
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the TtcA family. TtuA subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues, the fourth Fe with a free coordination site may bind a small ligand, such as exogenous sulfide, thus acting as a sulfur carrier.
messages: Catalyzes the ATP-dependent 2-thiolation of 5-methyluridine residue at position 54 in the T loop of tRNAs, leading to 5-methyl-2-thiouridine (m(5)s(2)U or s(2)T) (PubMed:28655838). This modification allows thermal stabilization of tRNAs in thermophilic microorganisms, and is required for cell growth at high temperatures (By similarity). Can use free sulfide as sulfur source in vitro, which may be also the sulfur source in vivo (PubMed:28655838).
messages: Homodimer.
messages: In TtuA from T.thermophilus, the sulfur inserted into the nucleoside comes from the C-terminal thiocarboxylate of TtuB, but there is no TtuB ortholog in P.horikoshii. Free sulfide has been shown to be present at relatively high concentrations within thermophilic archaea, and may be the sulfur source in vivo.
messages: The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster.

70601:PH RS07995
gene id: 70601:PH_RS07995
uniprot id: O59366
names: Similarity
messages: Belongs to the thymidylate kinase family.

70601:PH RS07100
gene id: 70601:PH_RS07100
uniprot id: O59171
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

70601:PH RS02575
gene id: 70601:PH_RS02575
uniprot id: O58286
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

70601:PH RS04610
gene id: 70601:PH_RS04610
uniprot id: O58706
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

70601:PH RS06620
gene id: 70601:PH_RS06620
uniprot id: O50107
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

70601:PH RS05950
gene id: 70601:PH_RS05950
uniprot id: O58988
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

70601:PH RS06630
gene id: 70601:PH_RS06630
uniprot id: O50109
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

70601:PH RS01645
gene id: 70601:PH_RS01645
uniprot id: O58107
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
messages: Cytoplasm

70601:PH RS08370
gene id: 70601:PH_RS08370
uniprot id: O59424
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

70601:PH RS07170
gene id: 70601:PH_RS07170
uniprot id: P62005
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.

70601:PH RS01410
gene id: 70601:PH_RS01410
uniprot id: O58054
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

70601:PH RS03200
gene id: 70601:PH_RS03200
uniprot id: O73986
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

70601:PH RS08185
gene id: 70601:PH_RS08185
uniprot id: O59381
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS05080
gene id: 70601:PH_RS05080
uniprot id: O58810
names: Function
names: Similarity
names: Subunit
messages: Belongs to the desulfoferrodoxin family.
messages: Homotetramer.
messages: Uses electrons from reduced NADP, by way of rubredoxin and an oxidoreductase, to catalyze the reduction of superoxide to hydrogen peroxide.

70601:PH RS05875
gene id: 70601:PH_RS05875
uniprot id: O58933
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

70601:PH RS08215
gene id: 70601:PH_RS08215
uniprot id: O59374
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

70601:PH RS06685
gene id: 70601:PH_RS06685
uniprot id: O50123
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

70601:PH RS02885
gene id: 70601:PH_RS02885
uniprot id: O58349
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

70601:PH RS02975
gene id: 70601:PH_RS02975
uniprot id: O58368
names: Cofactor
messages: Binds 1 zinc ion per subunit.

70601:PH RS02160
gene id: 70601:PH_RS02160
uniprot id: O58215
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
messages: Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
messages: Cell membrane

70601:PH RS05395
gene id: 70601:PH_RS05395
uniprot id: O58883
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

70601:PH RS07990
gene id: 70601:PH_RS07990
uniprot id: O59307
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

70601:PH RS01570
gene id: 70601:PH_RS01570
uniprot id: O58091
names: Similarity
messages: Belongs to the UPF0107 family.

70601:PH RS04030
gene id: 70601:PH_RS04030
uniprot id: O58587
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

70601:PH RS07845
gene id: 70601:PH_RS07845
uniprot id: O59339
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

70601:PH RS04755
gene id: 70601:PH_RS04755
uniprot id: O58737
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity).

70601:PH RS06680
gene id: 70601:PH_RS06680
uniprot id: O50122
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS04875
gene id: 70601:PH_RS04875
uniprot id: O58760
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Probably part of a binding-protein-dependent transport system PH1036/38/39. Probably responsible for the translocation of the substrate across the membrane.

70601:PH RS06435
gene id: 70601:PH_RS06435
uniprot id: O59082
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.

70601:PH RS04765
gene id: 70601:PH_RS04765
uniprot id: O58739
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

70601:PH RS04510
gene id: 70601:PH_RS04510
uniprot id: O58665
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

70601:PH RS06520
gene id: 70601:PH_RS06520
uniprot id: O50083
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Homotetramer.
messages: Inhibited by D-4-phosphoerythronic acid.
messages: Involved in the first step of the non-oxidative branch of the pentose phosphate pathway. It catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.

70601:PH RS08395
gene id: 70601:PH_RS08395
uniprot id: O59420
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

70601:PH RS09355
gene id: 70601:PH_RS09355
uniprot id: O57724
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

70601:PH RS09315
gene id: 70601:PH_RS09315
uniprot id: O57734
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Editing domain AlaX-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Functions in trans to edit the amino acid moiety from mischarged charged tRNA(Ala).

70601:PH RS07650
gene id: 70601:PH_RS07650
uniprot id: O59284
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Catalyzes the four-electron oxidation of UDP-N-acetyl-D-mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N-acetylmannosaminuronic acid (UDP-ManNAcA).
messages: Homodimer.
messages: The protomer folds into three distinct domains: an N-terminal nucleotide binding domain, a central helical domain involved in dimerization and a C-terminal substrate binding domain.

70601:PH RS07575
gene id: 70601:PH_RS07575
uniprot id: O59248
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 5 protein subunits. Forms a heterodimeric subcomplex with Rnp1. Reconstituted enzyme missing individual protein subunits is suboptimally active, showing each subunit contributes to optimization of activity.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Binds RNase P RNA.

70601:PH RS06380
gene id: 70601:PH_RS06380
uniprot id: O59070
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

70601:PH RS05705
gene id: 70601:PH_RS05705
uniprot id: O58968
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Probably part of a binding-protein-dependent transport system PH1214/15/16. Probably responsible for the translocation of the substrate across the membrane.

70601:PH RS03615
gene id: 70601:PH_RS03615
uniprot id: O58489
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Cytoplasm
messages: Homodimer.

70601:PH RS06905
gene id: 70601:PH_RS06905
uniprot id: O59132
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

70601:PH RS00605
gene id: 70601:PH_RS00605
uniprot id: O57871
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS02990
gene id: 70601:PH_RS02990
uniprot id: O58370
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

70601:PH RS06710
gene id: 70601:PH_RS06710
uniprot id: O50129
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate (By similarity). Has phosphatase activity towards p-nitrophenylphosphate (in vitro).
messages: Homodimer.

70601:PH RS09375
gene id: 70601:PH_RS09375
uniprot id: O57719
names: Domain
names: Function
messages: Part of a potassium transport system.
messages: The RCK N-terminal domain binds NAD and possibly other effectors. This is expected to cause a conformation change that regulates potassium transport (By similarity).

70601:PH RS08080
gene id: 70601:PH_RS08080
uniprot id: O59403
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BMP lipoprotein family.
messages: Cell membrane

70601:PH RS02445
gene id: 70601:PH_RS02445
uniprot id: O73977
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

70601:PH RS07135
gene id: 70601:PH_RS07135
uniprot id: O59180
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family.
messages: Homotrimer. Interacts with PH1510 and is cleaved by PH1510.
messages: Membrane

70601:PH RS08635
gene id: 70601:PH_RS08635
uniprot id: O59494
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

70601:PH RS05425
gene id: 70601:PH_RS05425
uniprot id: O58878
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

70601:PH RS05775
gene id: 70601:PH_RS05775
uniprot id: O58954
names: Domain
names: Function
names: Similarity
messages: Belongs to the archaeal N-glycosylase/DNA lyase (AGOG) family.
messages: Contains two alpha-helical subdomains, with the 8-oxoguanine binding site located in a cleft at their interface. Contains a helix-hairpin-helix (HhH) structural motif and a Gly/Pro-rich sequence followed by a conserved Asp (HhH-GPD motif).
messages: DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates.

70601:PH RS09340
gene id: 70601:PH_RS09340
uniprot id: O57728
names: Function
names: Miscellaneous
names: PTM
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.
messages: The intein interrupts the ATP-binding site.
messages: This protein undergoes a protein self splicing that involves a post-translational excision of the VDE intervening region (intein) followed by peptide ligation.

70601:PH RS07790
gene id: 70601:PH_RS07790
uniprot id: O59351
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

70601:PH RS06980
gene id: 70601:PH_RS06980
uniprot id: O59148
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

70601:PH RS04680
gene id: 70601:PH_RS04680
uniprot id: O58720
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CutA family.
messages: Binds 1 copper ion in the interface between two trimers.
messages: Cytoplasm
messages: Homotrimer. The binding of the copper ion probably leads to oligomerization.
messages: Involved in resistance toward heavy metals.

70601:PH RS08985
gene id: 70601:PH_RS08985
uniprot id: O74106
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

70601:PH RS08315
gene id: 70601:PH_RS08315
uniprot id: O59433
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

70601:PH RS04655
gene id: 70601:PH_RS04655
uniprot id: O58714
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

70601:PH RS07880
gene id: 70601:PH_RS07880
uniprot id: O59330
names: Similarity
messages: Belongs to the UPF0173 family.

70601:PH RS03420
gene id: 70601:PH_RS03420
uniprot id: O58456
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
messages: The diphthine intermediate is not stable in vitro and readily eliminates the trimethylamino group. It is not known whether the elimination reaction also occurs physiologically.

70601:PH RS05225
gene id: 70601:PH_RS05225
uniprot id: O58844
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

70601:PH RS07950
gene id: 70601:PH_RS07950
uniprot id: O59314
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

70601:PH RS05455
gene id: 70601:PH_RS05455
uniprot id: O58871
names: Similarity
messages: Belongs to the DtxR/MntR family.

70601:PH RS03195
gene id: 70601:PH_RS03195
uniprot id: O58415
names: Cofactor
names: Subunit
messages: Binds 2 [4Fe-4S] clusters.
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

70601:PH RS06260
gene id: 70601:PH_RS06260
uniprot id: O59045
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0252 family.
messages: Membrane

70601:PH RS08610
gene id: 70601:PH_RS08610
uniprot id: O59490
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

70601:PH RS06815
gene id: 70601:PH_RS06815
uniprot id: O59114
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

70601:PH RS00525
gene id: 70601:PH_RS00525
uniprot id: O57853
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

70601:PH RS03985
gene id: 70601:PH_RS03985
uniprot id: O58577
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Cytoplasm
messages: Homotetramer.

70601:PH RS00575
gene id: 70601:PH_RS00575
uniprot id: O57865
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.

70601:PH RS07680
gene id: 70601:PH_RS07680
uniprot id: O59291
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

70601:PH RS00485
gene id: 70601:PH_RS00485
uniprot id: O74081
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

70601:PH RS05640
gene id: 70601:PH_RS05640
uniprot id: O58893
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).

70601:PH RS03170
gene id: 70601:PH_RS03170
uniprot id: O58410
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

70601:PH RS03180
gene id: 70601:PH_RS03180
uniprot id: O58412
names: Cofactor
names: Subunit
messages: Binds 2 [4Fe-4S] clusters.
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

70601:PH RS06000
gene id: 70601:PH_RS06000
uniprot id: O59029
names: Similarity
messages: Belongs to the malic enzymes family.

70601:PH RS02295
gene id: 70601:PH_RS02295
uniprot id: O58226
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

70601:PH RS09020
gene id: 70601:PH_RS09020
uniprot id: O59571
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

70601:PH RS05255
gene id: 70601:PH_RS05255
uniprot id: O58851
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

70601:PH RS06725
gene id: 70601:PH_RS06725
uniprot id: O50131
names: Domain
names: Function
names: Similarity
names: Subunit
messages: A 'Glu switch' mechanism prevents L-ornithine from binding in an orientation that would lead to transamination of the alpha-amino group (PubMed:35337912). The side-chain of Glu-236 forms a salt bridge with that of Arg-419, closing the 'Glu switch' and thus preventing unsuitable L-ornithine binding (PubMed:35337912).
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the conversion of L-ornithine and 2-oxoglutarate to L-glutamate semialdehyde and L-glutamate (PubMed:35337912). L-ornithine is the best substrate, but the enzyme also shows good activity toward L-lysine, and low activity toward D-ornithine, D-lysine, 5-aminovalerate, 6-aminohexanoate and GABA (PubMed:35337912). The enzyme activity is specific for 2-oxoglutarate (PubMed:35337912).
messages: Homotetramer; dimer of dimers.

70601:PH RS00545
gene id: 70601:PH_RS00545
uniprot id: O57857
names: Function
names: Similarity
messages: Belongs to the FAU-1 family.
messages: Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.

70601:PH RS03575
gene id: 70601:PH_RS03575
uniprot id: O58496
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

70601:PH RS09175
gene id: 70601:PH_RS09175
uniprot id: O59601
names: Similarity
messages: Belongs to the HPS/KGPDC family. HPS subfamily.
messages: Belongs to the SIS family. PHI subfamily.

70601:PH RS03190
gene id: 70601:PH_RS03190
uniprot id: O58414
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

70601:PH RS00255
gene id: 70601:PH_RS00255
uniprot id: O57809
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

70601:PH RS03515
gene id: 70601:PH_RS03515
uniprot id: O58510
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

70601:PH RS06235
gene id: 70601:PH_RS06235
uniprot id: P58503
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

70601:PH RS03280
gene id: 70601:PH_RS03280
uniprot id: O58428
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

70601:PH RS08305
gene id: 70601:PH_RS08305
uniprot id: O59437
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

70601:PH RS07425
gene id: 70601:PH_RS07425
uniprot id: O59279
names: Similarity
messages: Belongs to the peptidase S49 family.

70601:PH RS08885
gene id: 70601:PH_RS08885
uniprot id: O59536
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

70601:PH RS04015
gene id: 70601:PH_RS04015
uniprot id: O58584
names: Similarity
messages: Belongs to the RutC family.

70601:PH RS07250
gene id: 70601:PH_RS07250
uniprot id: O59205
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

70601:PH RS00620
gene id: 70601:PH_RS00620
uniprot id: O57875
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

70601:PH RS01030
gene id: 70601:PH_RS01030
uniprot id: O57966
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

70601:PH RS06495
gene id: 70601:PH_RS06495
uniprot id: O59094
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS04500
gene id: 70601:PH_RS04500
uniprot id: O58667
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

70601:PH RS00905
gene id: 70601:PH_RS00905
uniprot id: O57939
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

70601:PH RS07685
gene id: 70601:PH_RS07685
uniprot id: O59292
names: Similarity
messages: Belongs to the MEMO1 family.

70601:PH RS04210
gene id: 70601:PH_RS04210
uniprot id: O58642
names: Similarity
messages: Belongs to the AOR/FOR family.

70601:PH RS09280
gene id: 70601:PH_RS09280
uniprot id: O59614
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

70601:PH RS02030
gene id: 70601:PH_RS02030
uniprot id: O58166
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

70601:PH RS07465
gene id: 70601:PH_RS07465
uniprot id: O59268
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

70601:PH RS08110
gene id: 70601:PH_RS08110
uniprot id: O59396
names: Similarity
messages: Belongs to the RimK family. LysX subfamily.

70601:PH RS06915
gene id: 70601:PH_RS06915
uniprot id: O59134
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

70601:PH RS08400
gene id: 70601:PH_RS08400
uniprot id: O59418
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

70601:PH RS00125
gene id: 70601:PH_RS00125
uniprot id: O57757
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

70601:PH RS01460
gene id: 70601:PH_RS01460
uniprot id: O58061
names: Cofactor
names: Similarity
messages: Belongs to the GARS family.
messages: Binds 2 magnesium or manganese ions per subunit.

70601:PH RS06500
gene id: 70601:PH_RS06500
uniprot id: O59096
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

70601:PH RS02085
gene id: 70601:PH_RS02085
uniprot id: O58185
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.
messages: Catalyzes the exchange of initiation factor 2-bound GDP for GTP.
messages: Complex of two different subunits.

70601:PH RS01365
gene id: 70601:PH_RS01365
uniprot id: P84142
names: Similarity
names: Subunit
messages: Belongs to the acylphosphatase family.
messages: Monomer.

70601:PH RS04745
gene id: 70601:PH_RS04745
uniprot id: O58734
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

70601:PH RS08965
gene id: 70601:PH_RS08965
uniprot id: O59521
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
messages: Cytoplasm

70601:PH RS00020
gene id: 70601:PH_RS00020
uniprot id: P58199
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

70601:PH RS04380
gene id: 70601:PH_RS04380
uniprot id: O58689
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Cytoplasm
messages: Transfers a mannosyl group from GDP-mannose to phosphoglycerate to form mannosyl-3-phosphoglycerate (MPG). The enzyme is absolutely specific for GDP-mannose and 3-phosphoglycerate, and transfers the mannosyl group with retention of configuration.

70601:PH RS08565
gene id: 70601:PH_RS08565
uniprot id: O59482
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

70601:PH RS00040
gene id: 70601:PH_RS00040
uniprot id: O57774
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

70601:PH RS01100
gene id: 70601:PH_RS01100
uniprot id: O57980
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

70601:PH RS05165
gene id: 70601:PH_RS05165
uniprot id: O58832
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the DPH1/DPH2 family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).
messages: Homodimer.
messages: In contrast to eukaryotes that require four gene products (DPH1, DPH2, DPH3 and DPH4) to catalyze the first step of diphthamide biosynthesis, no other protein than Dph2 is required in P.horikoshii.
messages: Unlike the enzymes in the radical SAM superfamily, Dph2 does not form the canonical 5'-deoxyadenosyl radical. Instead, it breaks the C(gamma)-S bond of SAM and generates a 3-amino-3-carboxypropyl radical intermediate. Thus, the P.horikoshii Dph2 represents a previously unknown, SAM-dependent, [4Fe-4S]-containing enzyme that catalyzes unprecedented chemistry. Moreover, the chemistry requires only one [4Fe-4S] cluster to be present in the Dph2 dimer, although each monomer can bind a [4Fe-4S] cluster.

70601:PH RS00095
gene id: 70601:PH_RS00095
uniprot id: O57764
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 2 family.
messages: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

70601:PH RS02090
gene id: 70601:PH_RS02090
uniprot id: O58183
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

70601:PH RS07700
gene id: 70601:PH_RS07700
uniprot id: O59296
names: Similarity
messages: Belongs to the enolase family.

70601:PH RS02100
gene id: 70601:PH_RS02100
uniprot id: O58180
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

70601:PH RS05325
gene id: 70601:PH_RS05325
uniprot id: O58864
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in tRNA.

70601:PH RS00130
gene id: 70601:PH_RS00130
uniprot id: O57756
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

70601:PH RS00270
gene id: 70601:PH_RS00270
uniprot id: O57805
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

70601:PH RS02720
gene id: 70601:PH_RS02720
uniprot id: O58336
names: Similarity
messages: Belongs to the UPF0047 family.

70601:PH RS01015
gene id: 70601:PH_RS01015
uniprot id: O57963
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm

70601:PH RS02795
gene id: 70601:PH_RS02795
uniprot id: O58323
names: Similarity
messages: Belongs to the peptidase S9C family.

70601:PH RS07740
gene id: 70601:PH_RS07740
uniprot id: O59303
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

70601:PH RS07305
gene id: 70601:PH_RS07305
uniprot id: O59227
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

70601:PH RS03425
gene id: 70601:PH_RS03425
uniprot id: O58457
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Homododecamer.
messages: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.

70601:PH RS02460
gene id: 70601:PH_RS02460
uniprot id: P59473
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

70601:PH RS02000
gene id: 70601:PH_RS02000
uniprot id: O58158
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS03070
gene id: 70601:PH_RS03070
uniprot id: O58389
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit. Contains one structural ion and one catalytic ion that seems to be less tightly bound at the site (PubMed:16233775). Zn(2+) can be replaced by Mn(2+) or Co(2+) to some extent (PubMed:15902509).
messages: Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate (PubMed:16233775, PubMed:15902509). Is much less efficient when using NADP(+) instead of NAD(+) (PubMed:16233775). To a lesser extent, also catalyzes the oxidation of L-serine and DL-threo-3-phenylserine, but not that of L-allo-threonine, D-threonine and D-allo-threonine and many other L-amino acids (PubMed:15902509).
messages: Cytoplasm
messages: Homodimer (PubMed:16233775). Homotetramer; dimer of dimers (PubMed:17188300) (PubMed:15902509).
messages: Is totally inhibited by EDTA in vitro.
messages: The enzyme shows pro-R stereospecificity for hydrogen transfer at the C4 position of the nicotinamide moiety of NADH.

70601:PH RS04005
gene id: 70601:PH_RS04005
uniprot id: O58581
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

70601:PH RS07770
gene id: 70601:PH_RS07770
uniprot id: O59357
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

70601:PH RS08595
gene id: 70601:PH_RS08595
uniprot id: O59487
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

70601:PH RS08010
gene id: 70601:PH_RS08010
uniprot id: O59362
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Binds two Mg(2+) per subunit.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome.

70601:PH RS07720
gene id: 70601:PH_RS07720
uniprot id: O59299
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

70601:PH RS06970
gene id: 70601:PH_RS06970
uniprot id: O59146
names: Similarity
messages: Belongs to the UPF0179 family.

70601:PH RS03085
gene id: 70601:PH_RS03085
uniprot id: O58393
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).

70601:PH RS00915
gene id: 70601:PH_RS00915
uniprot id: O57942
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS04780
gene id: 70601:PH_RS04780
uniprot id: O58742
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.

70601:PH RS08945
gene id: 70601:PH_RS08945
uniprot id: P60463
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer (By similarity).
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex (By similarity).

70601:PH RS06240
gene id: 70601:PH_RS06240
uniprot id: O59049
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

70601:PH RS03175
gene id: 70601:PH_RS03175
uniprot id: O58411
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

70601:PH RS08760
gene id: 70601:PH_RS08760
uniprot id: O74102
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

70601:PH RS06540
gene id: 70601:PH_RS06540
uniprot id: O50087
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

70601:PH RS07935
gene id: 70601:PH_RS07935
uniprot id: O59318
names: Similarity
messages: Belongs to the class-I fumarase family.

70601:PH RS06795
gene id: 70601:PH_RS06795
uniprot id: O59109
names: Subcellular Location Annotation
messages: Membrane

70601:PH RS05040
gene id: 70601:PH_RS05040
uniprot id: O58801
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. It can use ATP and other nucleoside triphosphates (GTP,UTP) as well as inorganic polyphosphate (poly(P)) as a source of phosphorus. NAD is the preferred substrate for the kinase, but NADH can also be used as phosphoryl acceptor.

70601:PH RS08235
gene id: 70601:PH_RS08235
uniprot id: O59371
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.