697303:THEWI RS04215
gene id: 697303:THEWI_RS04215
uniprot id: G2MWB7
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS06225
gene id: 697303:THEWI_RS06225
uniprot id: G2MVB8
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

697303:THEWI RS12090
gene id: 697303:THEWI_RS12090
uniprot id: G2MRM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VirD4/TraG family.
messages: Membrane

697303:THEWI RS03105
gene id: 697303:THEWI_RS03105
uniprot id: G2MS55
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

697303:THEWI RS09085
gene id: 697303:THEWI_RS09085
uniprot id: G2MWV3
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

697303:THEWI RS10190
gene id: 697303:THEWI_RS10190
uniprot id: G2MTG0
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

697303:THEWI RS03680
gene id: 697303:THEWI_RS03680
uniprot id: G2MV10
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

697303:THEWI RS09665
gene id: 697303:THEWI_RS09665
uniprot id: G2MRG2
names: Similarity
messages: Belongs to the ComB family.

697303:THEWI RS08995
gene id: 697303:THEWI_RS08995
uniprot id: G2MWT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

697303:THEWI RS05175
gene id: 697303:THEWI_RS05175
uniprot id: G2MR62
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

697303:THEWI RS03660
gene id: 697303:THEWI_RS03660
uniprot id: G2MV07
names: Similarity
messages: Belongs to the UPF0236 family.

697303:THEWI RS07640
gene id: 697303:THEWI_RS07640
uniprot id: G2MT54
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

697303:THEWI RS00485
gene id: 697303:THEWI_RS00485
uniprot id: G2MVT7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

697303:THEWI RS06255
gene id: 697303:THEWI_RS06255
uniprot id: G2MVC4
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS01920
gene id: 697303:THEWI_RS01920
uniprot id: G2MUX5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

697303:THEWI RS06945
gene id: 697303:THEWI_RS06945
uniprot id: G2MXE8
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Membrane

697303:THEWI RS11300
gene id: 697303:THEWI_RS11300
uniprot id: G2MWY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

697303:THEWI RS04650
gene id: 697303:THEWI_RS04650
uniprot id: G2MX84
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

697303:THEWI RS04245
gene id: 697303:THEWI_RS04245
uniprot id: G2MWC3
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.

697303:THEWI RS04725
gene id: 697303:THEWI_RS04725
uniprot id: G2MX99
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

697303:THEWI RS01060
gene id: 697303:THEWI_RS01060
uniprot id: G2MRW5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

697303:THEWI RS05780
gene id: 697303:THEWI_RS05780
uniprot id: G2MSZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

697303:THEWI RS08810
gene id: 697303:THEWI_RS08810
uniprot id: G2MWP9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS10700
gene id: 697303:THEWI_RS10700
uniprot id: G2MTX0
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

697303:THEWI RS12695
gene id: 697303:THEWI_RS12695
uniprot id: G2MU45
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS06765
gene id: 697303:THEWI_RS06765
uniprot id: G2MWN4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS03345
gene id: 697303:THEWI_RS03345
uniprot id: G2MSR8
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

697303:THEWI RS05565
gene id: 697303:THEWI_RS05565
uniprot id: G2MSF2
names: Similarity
messages: Belongs to the creatininase superfamily.

697303:THEWI RS01240
gene id: 697303:THEWI_RS01240
uniprot id: G2MS00
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS10170
gene id: 697303:THEWI_RS10170
uniprot id: G2MTF6
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS02075
gene id: 697303:THEWI_RS02075
uniprot id: G2MW18
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

697303:THEWI RS09245
gene id: 697303:THEWI_RS09245
uniprot id: G2MXL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS09660
gene id: 697303:THEWI_RS09660
uniprot id: G2MRG1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

697303:THEWI RS03745
gene id: 697303:THEWI_RS03745
uniprot id: G2MV23
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS03295
gene id: 697303:THEWI_RS03295
uniprot id: G2MSQ8
names: Similarity
messages: Belongs to the SAICAR synthetase family.

697303:THEWI RS07045
gene id: 697303:THEWI_RS07045
uniprot id: G2MXG8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

697303:THEWI RS03040
gene id: 697303:THEWI_RS03040
uniprot id: G2MS41
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

697303:THEWI RS06680
gene id: 697303:THEWI_RS06680
uniprot id: G2MWL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

697303:THEWI RS03595
gene id: 697303:THEWI_RS03595
uniprot id: G2MSV8
names: Similarity
messages: Belongs to the ThiD family.

697303:THEWI RS07650
gene id: 697303:THEWI_RS07650
uniprot id: G2MT56
names: Subcellular Location Annotation
messages: Cytoplasm

697303:THEWI RS12030
gene id: 697303:THEWI_RS12030
uniprot id: G2MRL7
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS04475
gene id: 697303:THEWI_RS04475
uniprot id: G2MX50
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

697303:THEWI RS11345
gene id: 697303:THEWI_RS11345
uniprot id: G2MWZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

697303:THEWI RS05060
gene id: 697303:THEWI_RS05060
uniprot id: G2MR39
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

697303:THEWI RS02000
gene id: 697303:THEWI_RS02000
uniprot id: G2MUZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS08415
gene id: 697303:THEWI_RS08415
uniprot id: G2MVF4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

697303:THEWI RS11120
gene id: 697303:THEWI_RS11120
uniprot id: G2MVS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).
messages: Membrane

697303:THEWI RS07050
gene id: 697303:THEWI_RS07050
uniprot id: G2MXG9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

697303:THEWI RS07320
gene id: 697303:THEWI_RS07320
uniprot id: G2MR96
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

697303:THEWI RS04750
gene id: 697303:THEWI_RS04750
uniprot id: G2MXA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

697303:THEWI RS10035
gene id: 697303:THEWI_RS10035
uniprot id: G2MTD0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

697303:THEWI RS06045
gene id: 697303:THEWI_RS06045
uniprot id: G2MV82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.

697303:THEWI RS07980
gene id: 697303:THEWI_RS07980
uniprot id: G2MTJ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS09105
gene id: 697303:THEWI_RS09105
uniprot id: G2MWV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

697303:THEWI RS06295
gene id: 697303:THEWI_RS06295
uniprot id: G2MVD3
names: Function
names: Similarity
messages: Belongs to the anti-sigma-factor family.
messages: Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.

697303:THEWI RS04720
gene id: 697303:THEWI_RS04720
uniprot id: G2MX98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

697303:THEWI RS00610
gene id: 697303:THEWI_RS00610
uniprot id: G2MVW2
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS12815
gene id: 697303:THEWI_RS12815
uniprot id: G2MU69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

697303:THEWI RS06850
gene id: 697303:THEWI_RS06850
uniprot id: G2MXC9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

697303:THEWI RS13015
gene id: 697303:THEWI_RS13015
uniprot id: G2MUB0
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

697303:THEWI RS10290
gene id: 697303:THEWI_RS10290
uniprot id: G2MTI0
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

697303:THEWI RS01645
gene id: 697303:THEWI_RS01645
uniprot id: G2MSP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

697303:THEWI RS09510
gene id: 697303:THEWI_RS09510
uniprot id: G2MXR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

697303:THEWI RS04360
gene id: 697303:THEWI_RS04360
uniprot id: G2MWE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

697303:THEWI RS00860
gene id: 697303:THEWI_RS00860
uniprot id: G2MW11
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS01755
gene id: 697303:THEWI_RS01755
uniprot id: G2MUU2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS13580
gene id: 697303:THEWI_RS13580
uniprot id: G2MUL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

697303:THEWI RS06810
gene id: 697303:THEWI_RS06810
uniprot id: G2MXC1
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

697303:THEWI RS02590
gene id: 697303:THEWI_RS02590
uniprot id: G2MQU3
names: Function
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: This protein is a Fe-Mo-cofactor biosynthetic component.

697303:THEWI RS03975
gene id: 697303:THEWI_RS03975
uniprot id: G2MV62
names: Similarity
messages: Belongs to the UPF0236 family.

697303:THEWI RS06625
gene id: 697303:THEWI_RS06625
uniprot id: G2MWK6
names: Similarity
messages: Belongs to the CinA family.

697303:THEWI RS08225
gene id: 697303:THEWI_RS08225
uniprot id: G2MTP0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

697303:THEWI RS05520
gene id: 697303:THEWI_RS05520
uniprot id: G2MSE2
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

697303:THEWI RS09830
gene id: 697303:THEWI_RS09830
uniprot id: G2MRI7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

697303:THEWI RS07105
gene id: 697303:THEWI_RS07105
uniprot id: G2MXI0
names: Similarity
messages: Belongs to the fabD family.

697303:THEWI RS00955
gene id: 697303:THEWI_RS00955
uniprot id: G2MRU7
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

697303:THEWI RS05945
gene id: 697303:THEWI_RS05945
uniprot id: G2MT32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

697303:THEWI RS01080
gene id: 697303:THEWI_RS01080
uniprot id: G2MRW9
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS06115
gene id: 697303:THEWI_RS06115
uniprot id: G2MV96
names: Similarity
messages: Belongs to the peptidase M24B family.

697303:THEWI RS12670
gene id: 697303:THEWI_RS12670
uniprot id: G2MU40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS09485
gene id: 697303:THEWI_RS09485
uniprot id: G2MXR0
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS11145
gene id: 697303:THEWI_RS11145
uniprot id: G2MVS7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

697303:THEWI RS04535
gene id: 697303:THEWI_RS04535
uniprot id: G2MX62
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS01130
gene id: 697303:THEWI_RS01130
uniprot id: G2MRX9
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

697303:THEWI RS04555
gene id: 697303:THEWI_RS04555
uniprot id: G2MX66
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

697303:THEWI RS03675
gene id: 697303:THEWI_RS03675
uniprot id: G2MV09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

697303:THEWI RS05070
gene id: 697303:THEWI_RS05070
uniprot id: G2MR41
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

697303:THEWI RS10630
gene id: 697303:THEWI_RS10630
uniprot id: G2MTV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic Ku family.
messages: Homodimer. Interacts with LigD.
messages: With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.

697303:THEWI RS13565
gene id: 697303:THEWI_RS13565
uniprot id: G2MUK8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpA which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpB RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpA.
messages: Has an N-terminal Jag-N domain and 2 RNA-binding domains (KH and R3H).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS10405
gene id: 697303:THEWI_RS10405
uniprot id: G2MTS0
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

697303:THEWI RS11795
gene id: 697303:THEWI_RS11795
uniprot id: G2MXV9
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

697303:THEWI RS02370
gene id: 697303:THEWI_RS02370
uniprot id: G2MW65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS04310
gene id: 697303:THEWI_RS04310
uniprot id: G2MWD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

697303:THEWI RS11130
gene id: 697303:THEWI_RS11130
uniprot id: G2MVS4
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

697303:THEWI RS00450
gene id: 697303:THEWI_RS00450
uniprot id: G2MUS3
names: Similarity
messages: Belongs to the class-I fumarase family.

697303:THEWI RS08425
gene id: 697303:THEWI_RS08425
uniprot id: G2MVF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

697303:THEWI RS03270
gene id: 697303:THEWI_RS03270
uniprot id: G2MSQ3
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

697303:THEWI RS07275
gene id: 697303:THEWI_RS07275
uniprot id: G2MR87
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS09060
gene id: 697303:THEWI_RS09060
uniprot id: G2MWU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS06880
gene id: 697303:THEWI_RS06880
uniprot id: G2MXD5
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

697303:THEWI RS13380
gene id: 697303:THEWI_RS13380
uniprot id: G2MUH8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

697303:THEWI RS03020
gene id: 697303:THEWI_RS03020
uniprot id: G2MS37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

697303:THEWI RS05725
gene id: 697303:THEWI_RS05725
uniprot id: G2MSY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

697303:THEWI RS03405
gene id: 697303:THEWI_RS03405
uniprot id: G2MST0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

697303:THEWI RS07595
gene id: 697303:THEWI_RS07595
uniprot id: G2MT45
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS12265
gene id: 697303:THEWI_RS12265
uniprot id: G2MRR4
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

697303:THEWI RS10865
gene id: 697303:THEWI_RS10865
uniprot id: G2MVN6
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

697303:THEWI RS03435
gene id: 697303:THEWI_RS03435
uniprot id: G2MST6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS12630
gene id: 697303:THEWI_RS12630
uniprot id: G2MU32
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

697303:THEWI RS00365
gene id: 697303:THEWI_RS00365
uniprot id: G2MUQ6
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

697303:THEWI RS04525
gene id: 697303:THEWI_RS04525
uniprot id: G2MX60
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS00760
gene id: 697303:THEWI_RS00760
uniprot id: G2MVZ2
names: Similarity
messages: Belongs to the HypE family.

697303:THEWI RS08380
gene id: 697303:THEWI_RS08380
uniprot id: G2MVE9
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

697303:THEWI RS12635
gene id: 697303:THEWI_RS12635
uniprot id: G2MU33
names: Similarity
messages: In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
messages: In the N-terminal section; belongs to the aldehyde dehydrogenase family.

697303:THEWI RS07265
gene id: 697303:THEWI_RS07265
uniprot id: G2MR85
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

697303:THEWI RS12495
gene id: 697303:THEWI_RS12495
uniprot id: G2MU08
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS03305
gene id: 697303:THEWI_RS03305
uniprot id: G2MSR0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

697303:THEWI RS09325
gene id: 697303:THEWI_RS09325
uniprot id: G2MXM9
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS04225
gene id: 697303:THEWI_RS04225
uniprot id: G2MWB9
names: Similarity
messages: Belongs to the phosphohexose mutase family.

697303:THEWI RS10215
gene id: 697303:THEWI_RS10215
uniprot id: G2MTG5
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

697303:THEWI RS04895
gene id: 697303:THEWI_RS04895
uniprot id: G2MR09
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

697303:THEWI RS08245
gene id: 697303:THEWI_RS08245
uniprot id: G2MTP4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

697303:THEWI RS08020
gene id: 697303:THEWI_RS08020
uniprot id: G2MTK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

697303:THEWI RS08460
gene id: 697303:THEWI_RS08460
uniprot id: G2MVG3
names: Similarity
messages: Belongs to the sigma-54 factor family.

697303:THEWI RS04510
gene id: 697303:THEWI_RS04510
uniprot id: G2MX57
names: Function
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family. DapH subfamily.
messages: Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.

697303:THEWI RS06600
gene id: 697303:THEWI_RS06600
uniprot id: G2MWK2
names: Function
names: Similarity
messages: Belongs to the RNase Y family.
messages: Endoribonuclease that initiates mRNA decay.

697303:THEWI RS00710
gene id: 697303:THEWI_RS00710
uniprot id: G2MVY2
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS12300
gene id: 697303:THEWI_RS12300
uniprot id: G2MRS1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Binds 1 Fe(2+) ion per subunit. The iron ion 2 is coordinated via four histidines and one cysteine residue.
messages: Binds 1 Fe(3+) ion per subunit. The iron ion 1 is coordinated via 4 cysteine residues.
messages: Catalyzes the one-electron reduction of superoxide anion radical to hydrogen peroxide at a nonheme ferrous iron center. Plays a fundamental role in case of oxidative stress via its superoxide detoxification activity.

697303:THEWI RS13550
gene id: 697303:THEWI_RS13550
uniprot id: G2MUK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

697303:THEWI RS06550
gene id: 697303:THEWI_RS06550
uniprot id: E0FY98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

697303:THEWI RS01160
gene id: 697303:THEWI_RS01160
uniprot id: G2MRY4
names: Function
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.
messages: Transcriptional repressor of xylose-utilizing enzymes.

697303:THEWI RS07665
gene id: 697303:THEWI_RS07665
uniprot id: G2MT59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

697303:THEWI RS01495
gene id: 697303:THEWI_RS01495
uniprot id: G2MSM1
names: Similarity
messages: Belongs to the OsmC/Ohr family.

697303:THEWI RS12585
gene id: 697303:THEWI_RS12585
uniprot id: G2MU24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Mediates magnesium influx to the cytosol.
messages: Membrane

697303:THEWI RS03615
gene id: 697303:THEWI_RS03615
uniprot id: G2MSW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

697303:THEWI RS00295
gene id: 697303:THEWI_RS00295
uniprot id: G2MUP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

697303:THEWI RS06615
gene id: 697303:THEWI_RS06615
uniprot id: G2MWK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

697303:THEWI RS07940
gene id: 697303:THEWI_RS07940
uniprot id: E0FVY1
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

697303:THEWI RS09390
gene id: 697303:THEWI_RS09390
uniprot id: G2MXP2
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

697303:THEWI RS00715
gene id: 697303:THEWI_RS00715
uniprot id: G2MVY3
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

697303:THEWI RS03725
gene id: 697303:THEWI_RS03725
uniprot id: G2MV19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

697303:THEWI RS03035
gene id: 697303:THEWI_RS03035
uniprot id: G2MS40
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

697303:THEWI RS01315
gene id: 697303:THEWI_RS01315
uniprot id: G2MSI5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. AddB/RexB type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of AddA and AddB.
messages: The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddB nuclease domain is not required for chi fragment generation; this subunit has 5' -> 3' nuclease activity.

697303:THEWI RS01735
gene id: 697303:THEWI_RS01735
uniprot id: G2MUT8
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS00455
gene id: 697303:THEWI_RS00455
uniprot id: G2MUS4
names: Similarity
messages: Belongs to the class-I fumarase family.

697303:THEWI RS04460
gene id: 697303:THEWI_RS04460
uniprot id: G2MX47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS08340
gene id: 697303:THEWI_RS08340
uniprot id: G2MTQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

697303:THEWI RS06090
gene id: 697303:THEWI_RS06090
uniprot id: G2MV91
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

697303:THEWI RS00440
gene id: 697303:THEWI_RS00440
uniprot id: G2MUS1
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

697303:THEWI RS05045
gene id: 697303:THEWI_RS05045
uniprot id: G2MR38
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

697303:THEWI RS08965
gene id: 697303:THEWI_RS08965
uniprot id: G2MWS8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.

697303:THEWI RS02975
gene id: 697303:THEWI_RS02975
uniprot id: G2MS28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.
messages: Cell membrane
messages: Membrane
messages: Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex.

697303:THEWI RS10185
gene id: 697303:THEWI_RS10185
uniprot id: G2MTF9
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

697303:THEWI RS00835
gene id: 697303:THEWI_RS00835
uniprot id: G2MW06
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS07040
gene id: 697303:THEWI_RS07040
uniprot id: G2MXG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

697303:THEWI RS05745
gene id: 697303:THEWI_RS05745
uniprot id: G2MSZ1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

697303:THEWI RS01490
gene id: 697303:THEWI_RS01490
uniprot id: G2MSM0
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

697303:THEWI RS06885
gene id: 697303:THEWI_RS06885
uniprot id: G2MXD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

697303:THEWI RS08220
gene id: 697303:THEWI_RS08220
uniprot id: G2MTN9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

697303:THEWI RS06870
gene id: 697303:THEWI_RS06870
uniprot id: G2MXD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

697303:THEWI RS04875
gene id: 697303:THEWI_RS04875
uniprot id: G2MR05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

697303:THEWI RS07180
gene id: 697303:THEWI_RS07180
uniprot id: G2MR68
names: Function
names: Similarity
messages: Belongs to the alpha/beta-type SASP family.
messages: SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.

697303:THEWI RS12745
gene id: 697303:THEWI_RS12745
uniprot id: G2MU55
names: Similarity
messages: Belongs to the SleB family.

697303:THEWI RS09945
gene id: 697303:THEWI_RS09945
uniprot id: G2MRK6
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

697303:THEWI RS02020
gene id: 697303:THEWI_RS02020
uniprot id: G2MUZ4
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

697303:THEWI RS09255
gene id: 697303:THEWI_RS09255
uniprot id: G2MXL6
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

697303:THEWI RS12640
gene id: 697303:THEWI_RS12640
uniprot id: G2MU34
names: Similarity
messages: Belongs to the peptidase C40 family.

697303:THEWI RS05105
gene id: 697303:THEWI_RS05105
uniprot id: G2MR48
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS03045
gene id: 697303:THEWI_RS03045
uniprot id: G2MS43
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

697303:THEWI RS11220
gene id: 697303:THEWI_RS11220
uniprot id: G2MWW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

697303:THEWI RS01910
gene id: 697303:THEWI_RS01910
uniprot id: G2MUX3
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
messages: May be involved in the biosynthesis of molybdopterin.

697303:THEWI RS03715
gene id: 697303:THEWI_RS03715
uniprot id: G2MV17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

697303:THEWI RS11380
gene id: 697303:THEWI_RS11380
uniprot id: G2MWZ8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

697303:THEWI RS09955
gene id: 697303:THEWI_RS09955
uniprot id: G2MTB4
names: Function
messages: Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.

697303:THEWI RS03075
gene id: 697303:THEWI_RS03075
uniprot id: G2MS49
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS01045
gene id: 697303:THEWI_RS01045
uniprot id: G2MRW3
names: Function
messages: Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.

697303:THEWI RS10030
gene id: 697303:THEWI_RS10030
uniprot id: G2MTC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpC family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

697303:THEWI RS03645
gene id: 697303:THEWI_RS03645
uniprot id: G2MV04
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS07165
gene id: 697303:THEWI_RS07165
uniprot id: G2MR65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

697303:THEWI RS05755
gene id: 697303:THEWI_RS05755
uniprot id: G2MSZ3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

697303:THEWI RS03735
gene id: 697303:THEWI_RS03735
uniprot id: G2MV21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

697303:THEWI RS05180
gene id: 697303:THEWI_RS05180
uniprot id: G2MR63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

697303:THEWI RS07035
gene id: 697303:THEWI_RS07035
uniprot id: G2MXG6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

697303:THEWI RS03565
gene id: 697303:THEWI_RS03565
uniprot id: G2MSV3
names: Similarity
messages: Belongs to the glutamate synthase family.

697303:THEWI RS06995
gene id: 697303:THEWI_RS06995
uniprot id: G2MXF8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

697303:THEWI RS12850
gene id: 697303:THEWI_RS12850
uniprot id: G2MU76
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS13235
gene id: 697303:THEWI_RS13235
uniprot id: G2MUF2
names: Cofactor
messages: Binds 1 zinc ion per subunit.

697303:THEWI RS11260
gene id: 697303:THEWI_RS11260
uniprot id: G2MWX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

697303:THEWI RS05775
gene id: 697303:THEWI_RS05775
uniprot id: G2MSZ7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

697303:THEWI RS02540
gene id: 697303:THEWI_RS02540
uniprot id: G2MQT3
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS01685
gene id: 697303:THEWI_RS01685
uniprot id: G2MUT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

697303:THEWI RS13180
gene id: 697303:THEWI_RS13180
uniprot id: G2MUE1
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS08110
gene id: 697303:THEWI_RS08110
uniprot id: G2MTL9
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

697303:THEWI RS11600
gene id: 697303:THEWI_RS11600
uniprot id: G2MXS1
names: Similarity
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.

697303:THEWI RS09130
gene id: 697303:THEWI_RS09130
uniprot id: G2MWV9
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

697303:THEWI RS03620
gene id: 697303:THEWI_RS03620
uniprot id: G2MSW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

697303:THEWI RS05580
gene id: 697303:THEWI_RS05580
uniprot id: G2MSF5
names: Function
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.
messages: Transcriptional repressor of xylose-utilizing enzymes.

697303:THEWI RS00855
gene id: 697303:THEWI_RS00855
uniprot id: G2MW10
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS00210
gene id: 697303:THEWI_RS00210
uniprot id: G2MUN3
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS04090
gene id: 697303:THEWI_RS04090
uniprot id: G2MW92
names: Similarity
messages: Belongs to the DSD1 family.

697303:THEWI RS08305
gene id: 697303:THEWI_RS08305
uniprot id: G2MTQ1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

697303:THEWI RS07290
gene id: 697303:THEWI_RS07290
uniprot id: G2MR90
names: Similarity
messages: Belongs to the RemA family.

697303:THEWI RS00735
gene id: 697303:THEWI_RS00735
uniprot id: G2MVY7
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

697303:THEWI RS12785
gene id: 697303:THEWI_RS12785
uniprot id: G2MU63
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

697303:THEWI RS00530
gene id: 697303:THEWI_RS00530
uniprot id: G2MVU6
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

697303:THEWI RS09310
gene id: 697303:THEWI_RS09310
uniprot id: G2MXM6
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

697303:THEWI RS00635
gene id: 697303:THEWI_RS00635
uniprot id: G2MVW7
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

697303:THEWI RS03400
gene id: 697303:THEWI_RS03400
uniprot id: G2MSS9
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS06990
gene id: 697303:THEWI_RS06990
uniprot id: G2MXF7
names: Similarity
messages: Belongs to the DprA/Smf family.

697303:THEWI RS12505
gene id: 697303:THEWI_RS12505
uniprot id: G2MU10
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

697303:THEWI RS11655
gene id: 697303:THEWI_RS11655
uniprot id: G2MXT2
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

697303:THEWI RS09990
gene id: 697303:THEWI_RS09990
uniprot id: G2MTC1
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the FGGY kinase family.
messages: Homotetramer and homodimer (in equilibrium).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

697303:THEWI RS04120
gene id: 697303:THEWI_RS04120
uniprot id: G2MW98
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

697303:THEWI RS11105
gene id: 697303:THEWI_RS11105
uniprot id: G2MVR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

697303:THEWI RS09340
gene id: 697303:THEWI_RS09340
uniprot id: G2MXN2
names: Similarity
messages: Belongs to the BtpA family.

697303:THEWI RS04905
gene id: 697303:THEWI_RS04905
uniprot id: G2MR11
names: Caution
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS02260
gene id: 697303:THEWI_RS02260
uniprot id: G2MW47
names: Similarity
messages: Belongs to the band 7/mec-2 family.

697303:THEWI RS02680
gene id: 697303:THEWI_RS02680
uniprot id: G2MQW0
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

697303:THEWI RS08430
gene id: 697303:THEWI_RS08430
uniprot id: G2MVF7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

697303:THEWI RS07100
gene id: 697303:THEWI_RS07100
uniprot id: G2MXH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

697303:THEWI RS11125
gene id: 697303:THEWI_RS11125
uniprot id: G2MVS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.

697303:THEWI RS02405
gene id: 697303:THEWI_RS02405
uniprot id: G2MW71
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

697303:THEWI RS08680
gene id: 697303:THEWI_RS08680
uniprot id: G2MVK3
names: Similarity
messages: Belongs to the LacAB/RpiB family.

697303:THEWI RS01775
gene id: 697303:THEWI_RS01775
uniprot id: G2MUU6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pseudouridine-5'-phosphate glycosidase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
messages: Homotrimer.

697303:THEWI RS07055
gene id: 697303:THEWI_RS07055
uniprot id: G2MXH0
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

697303:THEWI RS00400
gene id: 697303:THEWI_RS00400
uniprot id: G2MUR3
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

697303:THEWI RS08785
gene id: 697303:THEWI_RS08785
uniprot id: G2MWP4
names: Similarity
messages: Belongs to the manganese catalase family.

697303:THEWI RS01550
gene id: 697303:THEWI_RS01550
uniprot id: G2MSN2
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

697303:THEWI RS04985
gene id: 697303:THEWI_RS04985
uniprot id: G2MR26
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

697303:THEWI RS02645
gene id: 697303:THEWI_RS02645
uniprot id: G2MQV2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

697303:THEWI RS02970
gene id: 697303:THEWI_RS02970
uniprot id: G2MS27
names: Similarity
messages: Belongs to the carbamate kinase family.

697303:THEWI RS11115
gene id: 697303:THEWI_RS11115
uniprot id: G2MVS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the energy-coupling factor EcfT family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).
messages: Membrane
messages: Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.

697303:THEWI RS12665
gene id: 697303:THEWI_RS12665
uniprot id: G2MU39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS03010
gene id: 697303:THEWI_RS03010
uniprot id: G2MS35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

697303:THEWI RS07710
gene id: 697303:THEWI_RS07710
uniprot id: G2MT68
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

697303:THEWI RS02845
gene id: 697303:THEWI_RS02845
uniprot id: G2MQY7
names: Similarity
messages: Belongs to the asparagine synthetase family.

697303:THEWI RS02990
gene id: 697303:THEWI_RS02990
uniprot id: G2MS31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein bS18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

697303:THEWI RS00960
gene id: 697303:THEWI_RS00960
uniprot id: G2MRU8
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

697303:THEWI RS12730
gene id: 697303:THEWI_RS12730
uniprot id: G2MU52
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

697303:THEWI RS10325
gene id: 697303:THEWI_RS10325
uniprot id: G2MTI7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

697303:THEWI RS13555
gene id: 697303:THEWI_RS13555
uniprot id: G2MUK6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

697303:THEWI RS03290
gene id: 697303:THEWI_RS03290
uniprot id: G2MSQ7
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

697303:THEWI RS06960
gene id: 697303:THEWI_RS06960
uniprot id: G2MXF1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

697303:THEWI RS07955
gene id: 697303:THEWI_RS07955
uniprot id: G2MTB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

697303:THEWI RS13505
gene id: 697303:THEWI_RS13505
uniprot id: G2MUJ7
names: Function
names: Similarity
messages: Belongs to the peptidase S51 family.
messages: Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.

697303:THEWI RS07240
gene id: 697303:THEWI_RS07240
uniprot id: G2MR80
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

697303:THEWI RS01440
gene id: 697303:THEWI_RS01440
uniprot id: G2MSL0
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

697303:THEWI RS05805
gene id: 697303:THEWI_RS05805
uniprot id: G2MT04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

697303:THEWI RS01860
gene id: 697303:THEWI_RS01860
uniprot id: G2MUW3
names: Similarity
messages: Belongs to the AOR/FOR family.

697303:THEWI RS08850
gene id: 697303:THEWI_RS08850
uniprot id: G2MWQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS09370
gene id: 697303:THEWI_RS09370
uniprot id: G2MXN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

697303:THEWI RS10100
gene id: 697303:THEWI_RS10100
uniprot id: G2MTE3
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

697303:THEWI RS06630
gene id: 697303:THEWI_RS06630
uniprot id: G2MWK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

697303:THEWI RS07285
gene id: 697303:THEWI_RS07285
uniprot id: G2MR89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

697303:THEWI RS04655
gene id: 697303:THEWI_RS04655
uniprot id: G2MX85
names: Similarity
messages: Belongs to the UPF0340 family.

697303:THEWI RS04855
gene id: 697303:THEWI_RS04855
uniprot id: G2MR01
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

697303:THEWI RS04380
gene id: 697303:THEWI_RS04380
uniprot id: G2MWE9
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

697303:THEWI RS06775
gene id: 697303:THEWI_RS06775
uniprot id: G2MXB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

697303:THEWI RS00250
gene id: 697303:THEWI_RS00250
uniprot id: G2MUP1
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

697303:THEWI RS05170
gene id: 697303:THEWI_RS05170
uniprot id: G2MR61
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

697303:THEWI RS13540
gene id: 697303:THEWI_RS13540
uniprot id: G2MUK3
names: Similarity
messages: Belongs to the ParB family.

697303:THEWI RS09440
gene id: 697303:THEWI_RS09440
uniprot id: G2MXQ1
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

697303:THEWI RS11200
gene id: 697303:THEWI_RS11200
uniprot id: G2MWW2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

697303:THEWI RS11100
gene id: 697303:THEWI_RS11100
uniprot id: G2MVR8
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

697303:THEWI RS04445
gene id: 697303:THEWI_RS04445
uniprot id: G2MX44
names: Cofactor
messages: Binds 2 magnesium ions per subunit.

697303:THEWI RS12895
gene id: 697303:THEWI_RS12895
uniprot id: G2MU85
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

697303:THEWI RS05995
gene id: 697303:THEWI_RS05995
uniprot id: G2MV72
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Catalyzes the methylation of 5-hydroxyuridine (ho5U) to form 5-methoxyuridine (mo5U) at position 34 in tRNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS12945
gene id: 697303:THEWI_RS12945
uniprot id: G2MU95
names: Similarity
messages: Belongs to the UPF0175 family.

697303:THEWI RS06545
gene id: 697303:THEWI_RS06545
uniprot id: G2MWJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

697303:THEWI RS08905
gene id: 697303:THEWI_RS08905
uniprot id: G2MWR6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS05680
gene id: 697303:THEWI_RS05680
uniprot id: G2MSX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

697303:THEWI RS05020
gene id: 697303:THEWI_RS05020
uniprot id: G2MR33
names: Similarity
messages: Belongs to the asparagine synthetase family.

697303:THEWI RS13330
gene id: 697303:THEWI_RS13330
uniprot id: G2MUG9
names: Similarity
messages: Belongs to the CapA family.

697303:THEWI RS02135
gene id: 697303:THEWI_RS02135
uniprot id: G2MW30
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

697303:THEWI RS06335
gene id: 697303:THEWI_RS06335
uniprot id: G2MVE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ScpA family.
messages: Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.
messages: Cytoplasm
messages: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.

697303:THEWI RS14015
gene id: 697303:THEWI_RS14015
uniprot id: G2MWZ2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

697303:THEWI RS07000
gene id: 697303:THEWI_RS07000
uniprot id: G2MXF9
names: Similarity
messages: Belongs to the UPF0102 family.

697303:THEWI RS12855
gene id: 697303:THEWI_RS12855
uniprot id: G2MU77
names: Function
names: Similarity
messages: Belongs to the SpoVG family.
messages: Could be involved in septation.

697303:THEWI RS04075
gene id: 697303:THEWI_RS04075
uniprot id: G2MW89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

697303:THEWI RS10520
gene id: 697303:THEWI_RS10520
uniprot id: G2MTT8
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS01545
gene id: 697303:THEWI_RS01545
uniprot id: G2MSN1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

697303:THEWI RS05125
gene id: 697303:THEWI_RS05125
uniprot id: G2MR52
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Autoproteolytically processed. The inactive tetrameric zymogen termed p46 autoprocesses to a smaller form termed p41, which is active only during spore germination.
messages: Belongs to the peptidase A25 family.
messages: Homotetramer.
messages: Initiates the rapid degradation of small, acid-soluble proteins during spore germination.

697303:THEWI RS02015
gene id: 697303:THEWI_RS02015
uniprot id: G2MUZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
messages: Homodimer.
messages: Monomer.
messages: Secreted

697303:THEWI RS04600
gene id: 697303:THEWI_RS04600
uniprot id: G2MX74
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.
messages: Cytoplasm

697303:THEWI RS13320
gene id: 697303:THEWI_RS13320
uniprot id: G2MUG7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

697303:THEWI RS12130
gene id: 697303:THEWI_RS12130
uniprot id: G2MRN7
names: Similarity
messages: Belongs to the UPF0175 family.

697303:THEWI RS11310
gene id: 697303:THEWI_RS11310
uniprot id: G2MWY4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

697303:THEWI RS12375
gene id: 697303:THEWI_RS12375
uniprot id: G2MTY5
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS06855
gene id: 697303:THEWI_RS06855
uniprot id: G2MXD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

697303:THEWI RS00765
gene id: 697303:THEWI_RS00765
uniprot id: G2MVZ3
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

697303:THEWI RS01290
gene id: 697303:THEWI_RS01290
uniprot id: G2MSI0
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS04825
gene id: 697303:THEWI_RS04825
uniprot id: G2MQZ5
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

697303:THEWI RS02080
gene id: 697303:THEWI_RS02080
uniprot id: G2MW19
names: Similarity
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

697303:THEWI RS09410
gene id: 697303:THEWI_RS09410
uniprot id: G2MXP5
names: Similarity
messages: Belongs to the glycosyl hydrolase.

697303:THEWI RS04425
gene id: 697303:THEWI_RS04425
uniprot id: G2MX40
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

697303:THEWI RS11315
gene id: 697303:THEWI_RS11315
uniprot id: G2MWY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

697303:THEWI RS12755
gene id: 697303:THEWI_RS12755
uniprot id: G2MU57
names: Similarity
messages: Belongs to the GerABKC lipoprotein family.

697303:THEWI RS10640
gene id: 697303:THEWI_RS10640
uniprot id: G2MTW0
names: Similarity
messages: Belongs to the UPF0047 family.

697303:THEWI RS11280
gene id: 697303:THEWI_RS11280
uniprot id: G2MWX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

697303:THEWI RS05715
gene id: 697303:THEWI_RS05715
uniprot id: G2MSY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS07895
gene id: 697303:THEWI_RS07895
uniprot id: G2MT98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

697303:THEWI RS04275
gene id: 697303:THEWI_RS04275
uniprot id: G2MWC9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

697303:THEWI RS08900
gene id: 697303:THEWI_RS08900
uniprot id: G2MWR5
names: Similarity
messages: Belongs to the pyruvate kinase family.
messages: In the C-terminal section; belongs to the PEP-utilizing enzyme family.

697303:THEWI RS05800
gene id: 697303:THEWI_RS05800
uniprot id: G2MT03
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

697303:THEWI RS11555
gene id: 697303:THEWI_RS11555
uniprot id: G2MX34
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

697303:THEWI RS00545
gene id: 697303:THEWI_RS00545
uniprot id: G2MVU9
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

697303:THEWI RS00785
gene id: 697303:THEWI_RS00785
uniprot id: G2MVZ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

697303:THEWI RS01235
gene id: 697303:THEWI_RS01235
uniprot id: G2MRZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

697303:THEWI RS02560
gene id: 697303:THEWI_RS02560
uniprot id: G2MQT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.
messages: Homodimer.

697303:THEWI RS00070
gene id: 697303:THEWI_RS00070
uniprot id: G2MSG9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS12700
gene id: 697303:THEWI_RS12700
uniprot id: G2MU46
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS04780
gene id: 697303:THEWI_RS04780
uniprot id: G2MXA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

697303:THEWI RS11510
gene id: 697303:THEWI_RS11510
uniprot id: G2MX24
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

697303:THEWI RS07615
gene id: 697303:THEWI_RS07615
uniprot id: G2MT49
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

697303:THEWI RS05535
gene id: 697303:THEWI_RS05535
uniprot id: G2MSE6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

697303:THEWI RS01750
gene id: 697303:THEWI_RS01750
uniprot id: G2MUU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

697303:THEWI RS06055
gene id: 697303:THEWI_RS06055
uniprot id: G2MV84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP I family.
messages: Membrane

697303:THEWI RS00075
gene id: 697303:THEWI_RS00075
uniprot id: G2MSH0
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

697303:THEWI RS07125
gene id: 697303:THEWI_RS07125
uniprot id: G2MXI4
names: Function
names: Similarity
messages: Belongs to the FapR family.
messages: Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism.

697303:THEWI RS03720
gene id: 697303:THEWI_RS03720
uniprot id: G2MV18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

697303:THEWI RS06195
gene id: 697303:THEWI_RS06195
uniprot id: G2MVB2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

697303:THEWI RS08230
gene id: 697303:THEWI_RS08230
uniprot id: G2MTP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

697303:THEWI RS11140
gene id: 697303:THEWI_RS11140
uniprot id: G2MVS6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

697303:THEWI RS12660
gene id: 697303:THEWI_RS12660
uniprot id: G2MU38
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

697303:THEWI RS04315
gene id: 697303:THEWI_RS04315
uniprot id: G2MWD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

697303:THEWI RS01320
gene id: 697303:THEWI_RS01320
uniprot id: G2MSI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. AddA subfamily.
messages: Heterodimer of AddA and AddB/RexB.
messages: The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.

697303:THEWI RS07420
gene id: 697303:THEWI_RS07420
uniprot id: G2MRB3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

697303:THEWI RS12455
gene id: 697303:THEWI_RS12455
uniprot id: G2MU00
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

697303:THEWI RS05295
gene id: 697303:THEWI_RS05295
uniprot id: G2MSA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

697303:THEWI RS07315
gene id: 697303:THEWI_RS07315
uniprot id: G2MR95
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.

697303:THEWI RS03130
gene id: 697303:THEWI_RS03130
uniprot id: G2MS60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetokinase family.
messages: Cytoplasm

697303:THEWI RS10155
gene id: 697303:THEWI_RS10155
uniprot id: G2MTF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

697303:THEWI RS04300
gene id: 697303:THEWI_RS04300
uniprot id: G2MWD4
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS11185
gene id: 697303:THEWI_RS11185
uniprot id: G2MVT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

697303:THEWI RS09730
gene id: 697303:THEWI_RS09730
uniprot id: G2MRH5
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS05065
gene id: 697303:THEWI_RS05065
uniprot id: G2MR40
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

697303:THEWI RS03355
gene id: 697303:THEWI_RS03355
uniprot id: G2MSS0
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS06760
gene id: 697303:THEWI_RS06760
uniprot id: G2MWN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

697303:THEWI RS00605
gene id: 697303:THEWI_RS00605
uniprot id: G2MVW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

697303:THEWI RS12560
gene id: 697303:THEWI_RS12560
uniprot id: G2MU21
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

697303:THEWI RS11375
gene id: 697303:THEWI_RS11375
uniprot id: G2MWZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MrnC RNase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.

697303:THEWI RS12880
gene id: 697303:THEWI_RS12880
uniprot id: G2MU82
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

697303:THEWI RS13570
gene id: 697303:THEWI_RS13570
uniprot id: G2MUK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

697303:THEWI RS02900
gene id: 697303:THEWI_RS02900
uniprot id: G2MS13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

697303:THEWI RS10105
gene id: 697303:THEWI_RS10105
uniprot id: G2MTE4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

697303:THEWI RS13125
gene id: 697303:THEWI_RS13125
uniprot id: G2MUC9
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

697303:THEWI RS03550
gene id: 697303:THEWI_RS03550
uniprot id: G2MSV0
names: Similarity
messages: Belongs to the P(II) protein family.

697303:THEWI RS01200
gene id: 697303:THEWI_RS01200
uniprot id: G2MRZ2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

697303:THEWI RS06500
gene id: 697303:THEWI_RS06500
uniprot id: G2MWI2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

697303:THEWI RS01535
gene id: 697303:THEWI_RS01535
uniprot id: G2MSM9
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

697303:THEWI RS01420
gene id: 697303:THEWI_RS01420
uniprot id: G2MSK6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

697303:THEWI RS13185
gene id: 697303:THEWI_RS13185
uniprot id: G2MUE2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS11470
gene id: 697303:THEWI_RS11470
uniprot id: G2MX16
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

697303:THEWI RS06560
gene id: 697303:THEWI_RS06560
uniprot id: G2MWJ4
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

697303:THEWI RS10400
gene id: 697303:THEWI_RS10400
uniprot id: G2MTR9
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

697303:THEWI RS07010
gene id: 697303:THEWI_RS07010
uniprot id: G2MXG1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

697303:THEWI RS03480
gene id: 697303:THEWI_RS03480
uniprot id: G2MSU5
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

697303:THEWI RS05390
gene id: 697303:THEWI_RS05390
uniprot id: G2MSB6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

697303:THEWI RS11595
gene id: 697303:THEWI_RS11595
uniprot id: G2MXS0
names: Similarity
messages: Belongs to the GerABKA family.

697303:THEWI RS12935
gene id: 697303:THEWI_RS12935
uniprot id: G2MU93
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

697303:THEWI RS06570
gene id: 697303:THEWI_RS06570
uniprot id: G2MWJ6
names: Similarity
messages: Belongs to the CbxX/CfxQ family.

697303:THEWI RS03260
gene id: 697303:THEWI_RS03260
uniprot id: G2MSQ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

697303:THEWI RS07620
gene id: 697303:THEWI_RS07620
uniprot id: G2MT50
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage.

697303:THEWI RS00105
gene id: 697303:THEWI_RS00105
uniprot id: G2MUL4
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

697303:THEWI RS10820
gene id: 697303:THEWI_RS10820
uniprot id: G2MVM7
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

697303:THEWI RS02140
gene id: 697303:THEWI_RS02140
uniprot id: G2MW31
names: Caution
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS02780
gene id: 697303:THEWI_RS02780
uniprot id: G2MQX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
messages: Belongs to the FliW family.
messages: Cytoplasm
messages: Interacts with translational regulator CsrA and flagellin(s).

697303:THEWI RS00150
gene id: 697303:THEWI_RS00150
uniprot id: G2MUM2
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

697303:THEWI RS03395
gene id: 697303:THEWI_RS03395
uniprot id: G2MSS8
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

697303:THEWI RS01840
gene id: 697303:THEWI_RS01840
uniprot id: G2MUV9
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

697303:THEWI RS10375
gene id: 697303:THEWI_RS10375
uniprot id: G2MTR8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

697303:THEWI RS00480
gene id: 697303:THEWI_RS00480
uniprot id: G2MVT6
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

697303:THEWI RS08240
gene id: 697303:THEWI_RS08240
uniprot id: G2MTP3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

697303:THEWI RS02790
gene id: 697303:THEWI_RS02790
uniprot id: G2MQX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

697303:THEWI RS11160
gene id: 697303:THEWI_RS11160
uniprot id: G2MVT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

697303:THEWI RS10095
gene id: 697303:THEWI_RS10095
uniprot id: G2MTE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

697303:THEWI RS09420
gene id: 697303:THEWI_RS09420
uniprot id: G2MXP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS08540
gene id: 697303:THEWI_RS08540
uniprot id: G2MVH9
names: Similarity
messages: Belongs to the UPF0236 family.

697303:THEWI RS11915
gene id: 697303:THEWI_RS11915
uniprot id: G2MXY0
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

697303:THEWI RS10805
gene id: 697303:THEWI_RS10805
uniprot id: G2MVM4
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

697303:THEWI RS06955
gene id: 697303:THEWI_RS06955
uniprot id: G2MXF0
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

697303:THEWI RS07085
gene id: 697303:THEWI_RS07085
uniprot id: G2MXH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

697303:THEWI RS06905
gene id: 697303:THEWI_RS06905
uniprot id: G2MXE0
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

697303:THEWI RS03690
gene id: 697303:THEWI_RS03690
uniprot id: G2MV12
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

697303:THEWI RS07225
gene id: 697303:THEWI_RS07225
uniprot id: G2MR77
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

697303:THEWI RS00795
gene id: 697303:THEWI_RS00795
uniprot id: G2MVZ9
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

697303:THEWI RS07065
gene id: 697303:THEWI_RS07065
uniprot id: G2MXH2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

697303:THEWI RS08805
gene id: 697303:THEWI_RS08805
uniprot id: G2MWP8
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

697303:THEWI RS04515
gene id: 697303:THEWI_RS04515
uniprot id: G2MX58
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

697303:THEWI RS09475
gene id: 697303:THEWI_RS09475
uniprot id: G2MXQ8
names: Subcellular Location Annotation
messages: Cytoplasm

697303:THEWI RS06395
gene id: 697303:THEWI_RS06395
uniprot id: G2MWG1
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

697303:THEWI RS02420
gene id: 697303:THEWI_RS02420
uniprot id: G2MW74
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

697303:THEWI RS11540
gene id: 697303:THEWI_RS11540
uniprot id: G2MX31
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

697303:THEWI RS06030
gene id: 697303:THEWI_RS06030
uniprot id: G2MV79
names: Similarity
messages: Belongs to the GSP E family.

697303:THEWI RS00490
gene id: 697303:THEWI_RS00490
uniprot id: G2MVT8
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

697303:THEWI RS07730
gene id: 697303:THEWI_RS07730
uniprot id: G2MT71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

697303:THEWI RS04890
gene id: 697303:THEWI_RS04890
uniprot id: G2MR08
names: Function
names: Similarity
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.

697303:THEWI RS01835
gene id: 697303:THEWI_RS01835
uniprot id: G2MUV8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

697303:THEWI RS08725
gene id: 697303:THEWI_RS08725
uniprot id: G2MVL2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.

697303:THEWI RS02635
gene id: 697303:THEWI_RS02635
uniprot id: G2MQV0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

697303:THEWI RS02730
gene id: 697303:THEWI_RS02730
uniprot id: G2MQW7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

697303:THEWI RS07340
gene id: 697303:THEWI_RS07340
uniprot id: G2MRA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

697303:THEWI RS07625
gene id: 697303:THEWI_RS07625
uniprot id: G2MT51
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

697303:THEWI RS10225
gene id: 697303:THEWI_RS10225
uniprot id: G2MTG7
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS08655
gene id: 697303:THEWI_RS08655
uniprot id: G2MVJ8
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

697303:THEWI RS07115
gene id: 697303:THEWI_RS07115
uniprot id: G2MXI2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

697303:THEWI RS00010
gene id: 697303:THEWI_RS00010
uniprot id: G2MSF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

697303:THEWI RS08895
gene id: 697303:THEWI_RS08895
uniprot id: G2MWR4
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

697303:THEWI RS04240
gene id: 697303:THEWI_RS04240
uniprot id: G2MWC2
names: Similarity
messages: Belongs to the CpsD/CapB family.

697303:THEWI RS08960
gene id: 697303:THEWI_RS08960
uniprot id: G2MWS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS01965
gene id: 697303:THEWI_RS01965
uniprot id: G2MUY3
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

697303:THEWI RS00880
gene id: 697303:THEWI_RS00880
uniprot id: G2MRT2
names: Function
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

697303:THEWI RS00300
gene id: 697303:THEWI_RS00300
uniprot id: G2MUP8
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

697303:THEWI RS12995
gene id: 697303:THEWI_RS12995
uniprot id: G2MUA6
names: Similarity
messages: Belongs to the UPF0735 family.

697303:THEWI RS01265
gene id: 697303:THEWI_RS01265
uniprot id: G2MSH5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS03315
gene id: 697303:THEWI_RS03315
uniprot id: G2MSR2
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

697303:THEWI RS03280
gene id: 697303:THEWI_RS03280
uniprot id: G2MSQ5
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

697303:THEWI RS05445
gene id: 697303:THEWI_RS05445
uniprot id: G2MSC7
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

697303:THEWI RS06205
gene id: 697303:THEWI_RS06205
uniprot id: G2MVB4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

697303:THEWI RS03730
gene id: 697303:THEWI_RS03730
uniprot id: G2MV20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

697303:THEWI RS01030
gene id: 697303:THEWI_RS01030
uniprot id: G2MRW0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

697303:THEWI RS09450
gene id: 697303:THEWI_RS09450
uniprot id: G2MXQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.
messages: Cytoplasm

697303:THEWI RS04760
gene id: 697303:THEWI_RS04760
uniprot id: G2MXA6
names: Similarity
messages: Belongs to the NadC/ModD family.

697303:THEWI RS07680
gene id: 697303:THEWI_RS07680
uniprot id: G2MT62
names: Similarity
messages: Belongs to the RutC family.

697303:THEWI RS07480
gene id: 697303:THEWI_RS07480
uniprot id: G2MRC0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

697303:THEWI RS07975
gene id: 697303:THEWI_RS07975
uniprot id: G2MTJ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS08775
gene id: 697303:THEWI_RS08775
uniprot id: G2MWP1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

697303:THEWI RS06120
gene id: 697303:THEWI_RS06120
uniprot id: G2MV97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

697303:THEWI RS12940
gene id: 697303:THEWI_RS12940
uniprot id: G2MU94
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

697303:THEWI RS12410
gene id: 697303:THEWI_RS12410
uniprot id: G2MTZ1
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

697303:THEWI RS09445
gene id: 697303:THEWI_RS09445
uniprot id: G2MXQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
messages: Cytoplasm

697303:THEWI RS12550
gene id: 697303:THEWI_RS12550
uniprot id: G2MU19
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

697303:THEWI RS12295
gene id: 697303:THEWI_RS12295
uniprot id: G2MRS0
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

697303:THEWI RS09625
gene id: 697303:THEWI_RS09625
uniprot id: G2MRF4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
messages: Homohexamer.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

697303:THEWI RS12860
gene id: 697303:THEWI_RS12860
uniprot id: G2MU78
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

697303:THEWI RS03440
gene id: 697303:THEWI_RS03440
uniprot id: G2MST7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS07385
gene id: 697303:THEWI_RS07385
uniprot id: G2MRA6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm

697303:THEWI RS04345
gene id: 697303:THEWI_RS04345
uniprot id: G2MWE2
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

697303:THEWI RS07485
gene id: 697303:THEWI_RS07485
uniprot id: G2MRC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS10055
gene id: 697303:THEWI_RS10055
uniprot id: G2MTD4
names: Similarity
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.

697303:THEWI RS11330
gene id: 697303:THEWI_RS11330
uniprot id: G2MWY8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

697303:THEWI RS05115
gene id: 697303:THEWI_RS05115
uniprot id: G2MR50
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

697303:THEWI RS11265
gene id: 697303:THEWI_RS11265
uniprot id: G2MWX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

697303:THEWI RS00005
gene id: 697303:THEWI_RS00005
uniprot id: G2MSF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

697303:THEWI RS06695
gene id: 697303:THEWI_RS06695
uniprot id: G2MWM0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

697303:THEWI RS07120
gene id: 697303:THEWI_RS07120
uniprot id: G2MXI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

697303:THEWI RS09620
gene id: 697303:THEWI_RS09620
uniprot id: G2MRF3
names: Cofactor
names: Similarity
messages: Belongs to the PHP family.
messages: Binds 3 Zn(2+) ions per subunit.

697303:THEWI RS07935
gene id: 697303:THEWI_RS07935
uniprot id: G2MTA6
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

697303:THEWI RS08885
gene id: 697303:THEWI_RS08885
uniprot id: G2MWR3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

697303:THEWI RS01790
gene id: 697303:THEWI_RS01790
uniprot id: G2MUU9
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS13375
gene id: 697303:THEWI_RS13375
uniprot id: G2MUH7
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS00035
gene id: 697303:THEWI_RS00035
uniprot id: G2MSG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

697303:THEWI RS11450
gene id: 697303:THEWI_RS11450
uniprot id: G2MX12
names: Activity Regulation
names: Function
names: Similarity
messages: Appears to be allosterically activated by the binding of pArg-containing polypeptides to the pArg-binding pocket localized in the C-terminal domain of McsB.
messages: Belongs to the ATP:guanido phosphotransferase family.
messages: Catalyzes the specific phosphorylation of arginine residues in proteins.

697303:THEWI RS09035
gene id: 697303:THEWI_RS09035
uniprot id: G2MWU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

697303:THEWI RS07280
gene id: 697303:THEWI_RS07280
uniprot id: G2MR88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

697303:THEWI RS02410
gene id: 697303:THEWI_RS02410
uniprot id: G2MW72
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

697303:THEWI RS04520
gene id: 697303:THEWI_RS04520
uniprot id: G2MX59
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

697303:THEWI RS12965
gene id: 697303:THEWI_RS12965
uniprot id: G2MUA0
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

697303:THEWI RS08070
gene id: 697303:THEWI_RS08070
uniprot id: G2MTL1
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

697303:THEWI RS07030
gene id: 697303:THEWI_RS07030
uniprot id: G2MXG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

697303:THEWI RS12485
gene id: 697303:THEWI_RS12485
uniprot id: G2MU06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

697303:THEWI RS05240
gene id: 697303:THEWI_RS05240
uniprot id: G2MS91
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

697303:THEWI RS03410
gene id: 697303:THEWI_RS03410
uniprot id: G2MST1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

697303:THEWI RS06845
gene id: 697303:THEWI_RS06845
uniprot id: G2MXC8
names: Function
names: Similarity
messages: Belongs to the GTP-binding SRP family.
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

697303:THEWI RS09300
gene id: 697303:THEWI_RS09300
uniprot id: G2MXM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

697303:THEWI RS06665
gene id: 697303:THEWI_RS06665
uniprot id: G2MWL4
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

697303:THEWI RS04730
gene id: 697303:THEWI_RS04730
uniprot id: G2MXA0
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS11520
gene id: 697303:THEWI_RS11520
uniprot id: G2MX26
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

697303:THEWI RS02500
gene id: 697303:THEWI_RS02500
uniprot id: G2MQS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS12040
gene id: 697303:THEWI_RS12040
uniprot id: G2MRL9
names: Similarity
messages: Belongs to the GSP E family.

697303:THEWI RS02235
gene id: 697303:THEWI_RS02235
uniprot id: G2MW45
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

697303:THEWI RS00930
gene id: 697303:THEWI_RS00930
uniprot id: G2MRU1
names: Similarity
names: Subunit
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

697303:THEWI RS10080
gene id: 697303:THEWI_RS10080
uniprot id: G2MTD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

697303:THEWI RS02310
gene id: 697303:THEWI_RS02310
uniprot id: G2MW56
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

697303:THEWI RS07205
gene id: 697303:THEWI_RS07205
uniprot id: G2MR73
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

697303:THEWI RS00505
gene id: 697303:THEWI_RS00505
uniprot id: G2MVU1
names: Similarity
messages: Belongs to the DsrF/TusC family.

697303:THEWI RS04645
gene id: 697303:THEWI_RS04645
uniprot id: G2MX83
names: Subcellular Location Annotation
messages: Cell membrane

697303:THEWI RS05970
gene id: 697303:THEWI_RS05970
uniprot id: G2MT37
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

697303:THEWI RS06635
gene id: 697303:THEWI_RS06635
uniprot id: G2MWK8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
messages: Cytoplasm

697303:THEWI RS05235
gene id: 697303:THEWI_RS05235
uniprot id: G2MS90
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

697303:THEWI RS09635
gene id: 697303:THEWI_RS09635
uniprot id: G2MRF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

697303:THEWI RS08915
gene id: 697303:THEWI_RS08915
uniprot id: G2MWR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-C family. DnaE subfamily.
messages: Cytoplasm
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase.

697303:THEWI RS00190
gene id: 697303:THEWI_RS00190
uniprot id: G2MUM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit B family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS13310
gene id: 697303:THEWI_RS13310
uniprot id: G2MUG5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

697303:THEWI RS07575
gene id: 697303:THEWI_RS07575
uniprot id: G2MT41
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

697303:THEWI RS00435
gene id: 697303:THEWI_RS00435
uniprot id: G2MUS0
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS06490
gene id: 697303:THEWI_RS06490
uniprot id: G2MWI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

697303:THEWI RS01100
gene id: 697303:THEWI_RS01100
uniprot id: G2MRX3
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

697303:THEWI RS01055
gene id: 697303:THEWI_RS01055
uniprot id: G2MRW4
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

697303:THEWI RS05340
gene id: 697303:THEWI_RS05340
uniprot id: G2MSA9
names: Similarity
messages: Belongs to the peptidase C56 family.

697303:THEWI RS11725
gene id: 697303:THEWI_RS11725
uniprot id: G2MXU5
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS09645
gene id: 697303:THEWI_RS09645
uniprot id: G2MRF8
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS11285
gene id: 697303:THEWI_RS11285
uniprot id: G2MWZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

697303:THEWI RS03640
gene id: 697303:THEWI_RS03640
uniprot id: G2MV03
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS10070
gene id: 697303:THEWI_RS10070
uniprot id: G2MTD7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS09615
gene id: 697303:THEWI_RS09615
uniprot id: G2MRF2
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

697303:THEWI RS08500
gene id: 697303:THEWI_RS08500
uniprot id: G2MVH1
names: Similarity
messages: Belongs to the peptidase S16 family.

697303:THEWI RS08010
gene id: 697303:THEWI_RS08010
uniprot id: G2MTJ9
names: Similarity
messages: Belongs to the transpeptidase family.

697303:THEWI RS07300
gene id: 697303:THEWI_RS07300
uniprot id: G2MR92
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS07900
gene id: 697303:THEWI_RS07900
uniprot id: G2MT99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

697303:THEWI RS12380
gene id: 697303:THEWI_RS12380
uniprot id: G2MTY6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ApbE family.
messages: Cell inner membrane
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

697303:THEWI RS03155
gene id: 697303:THEWI_RS03155
uniprot id: G2MS66
names: Similarity
messages: Belongs to the asp23 family.

697303:THEWI RS11480
gene id: 697303:THEWI_RS11480
uniprot id: G2MX18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

697303:THEWI RS10980
gene id: 697303:THEWI_RS10980
uniprot id: G2MVQ6
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

697303:THEWI RS10115
gene id: 697303:THEWI_RS10115
uniprot id: G2MTE6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
messages: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

697303:THEWI RS05720
gene id: 697303:THEWI_RS05720
uniprot id: G2MSY7
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

697303:THEWI RS00495
gene id: 697303:THEWI_RS00495
uniprot id: G2MVT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane
messages: Membrane

697303:THEWI RS11180
gene id: 697303:THEWI_RS11180
uniprot id: G2MVT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

697303:THEWI RS06175
gene id: 697303:THEWI_RS06175
uniprot id: G2MVA8
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

697303:THEWI RS02465
gene id: 697303:THEWI_RS02465
uniprot id: G2MQR9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS01955
gene id: 697303:THEWI_RS01955
uniprot id: G2MUY1
names: Similarity
messages: Belongs to the mannitol dehydrogenase family.

697303:THEWI RS07245
gene id: 697303:THEWI_RS07245
uniprot id: G2MR81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

697303:THEWI RS01395
gene id: 697303:THEWI_RS01395
uniprot id: G2MSK1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS05770
gene id: 697303:THEWI_RS05770
uniprot id: G2MSZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

697303:THEWI RS08125
gene id: 697303:THEWI_RS08125
uniprot id: G2MTM2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

697303:THEWI RS03685
gene id: 697303:THEWI_RS03685
uniprot id: G2MV11
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

697303:THEWI RS02160
gene id: 697303:THEWI_RS02160
uniprot id: G2MW34
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

697303:THEWI RS09535
gene id: 697303:THEWI_RS09535
uniprot id: G2MRD6
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

697303:THEWI RS09335
gene id: 697303:THEWI_RS09335
uniprot id: G2MXN1
names: Similarity
messages: Belongs to the FGGY kinase family.

697303:THEWI RS02435
gene id: 697303:THEWI_RS02435
uniprot id: G2MW76
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS06530
gene id: 697303:THEWI_RS06530
uniprot id: G2MWI8
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

697303:THEWI RS06430
gene id: 697303:THEWI_RS06430
uniprot id: G2MWG8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

697303:THEWI RS00655
gene id: 697303:THEWI_RS00655
uniprot id: G2MVX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

697303:THEWI RS11705
gene id: 697303:THEWI_RS11705
uniprot id: G2MXU1
names: Similarity
messages: Belongs to the EamA transporter family.

697303:THEWI RS02515
gene id: 697303:THEWI_RS02515
uniprot id: G2MQS8
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

697303:THEWI RS08250
gene id: 697303:THEWI_RS08250
uniprot id: G2MTP5
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS01895
gene id: 697303:THEWI_RS01895
uniprot id: G2MUX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS03705
gene id: 697303:THEWI_RS03705
uniprot id: G2MV15
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

697303:THEWI RS10580
gene id: 697303:THEWI_RS10580
uniprot id: G2MTU9
names: Subcellular Location Annotation
messages: Cytoplasm

697303:THEWI RS10565
gene id: 697303:THEWI_RS10565
uniprot id: G2MTU6
names: Similarity
messages: Belongs to the archaeal-type GPI family.

697303:THEWI RS08095
gene id: 697303:THEWI_RS08095
uniprot id: G2MTL6
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

697303:THEWI RS02665
gene id: 697303:THEWI_RS02665
uniprot id: G2MQV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS10040
gene id: 697303:THEWI_RS10040
uniprot id: G2MTD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

697303:THEWI RS08065
gene id: 697303:THEWI_RS08065
uniprot id: G2MTL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

697303:THEWI RS10495
gene id: 697303:THEWI_RS10495
uniprot id: G2MTT3
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

697303:THEWI RS00245
gene id: 697303:THEWI_RS00245
uniprot id: G2MUP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

697303:THEWI RS03740
gene id: 697303:THEWI_RS03740
uniprot id: G2MV22
names: Similarity
messages: Belongs to the EamA transporter family.

697303:THEWI RS02550
gene id: 697303:THEWI_RS02550
uniprot id: G2MQT5
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

697303:THEWI RS05490
gene id: 697303:THEWI_RS05490
uniprot id: G2MSD6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

697303:THEWI RS11245
gene id: 697303:THEWI_RS11245
uniprot id: G2MWX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

697303:THEWI RS05990
gene id: 697303:THEWI_RS05990
uniprot id: G2MV71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

697303:THEWI RS00550
gene id: 697303:THEWI_RS00550
uniprot id: G2MVV0
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

697303:THEWI RS01475
gene id: 697303:THEWI_RS01475
uniprot id: G2MSL7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

697303:THEWI RS11445
gene id: 697303:THEWI_RS11445
uniprot id: G2MX11
names: Similarity
messages: Belongs to the ClpA/ClpB family.

697303:THEWI RS07130
gene id: 697303:THEWI_RS07130
uniprot id: G2MXI5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

697303:THEWI RS11275
gene id: 697303:THEWI_RS11275
uniprot id: G2MWX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

697303:THEWI RS06460
gene id: 697303:THEWI_RS06460
uniprot id: G2MWH4
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

697303:THEWI RS02460
gene id: 697303:THEWI_RS02460
uniprot id: G2MQR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

697303:THEWI RS13635
gene id: 697303:THEWI_RS13635
uniprot id: G2MV65
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS03905
gene id: 697303:THEWI_RS03905
uniprot id: G2MV50
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

697303:THEWI RS00090
gene id: 697303:THEWI_RS00090
uniprot id: G2MSH3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

697303:THEWI RS06515
gene id: 697303:THEWI_RS06515
uniprot id: G2MWI5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

697303:THEWI RS06110
gene id: 697303:THEWI_RS06110
uniprot id: G2MV95
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

697303:THEWI RS07415
gene id: 697303:THEWI_RS07415
uniprot id: G2MRB2
names: Similarity
messages: Belongs to the HypE family.

697303:THEWI RS07270
gene id: 697303:THEWI_RS07270
uniprot id: G2MR86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

697303:THEWI RS09655
gene id: 697303:THEWI_RS09655
uniprot id: G2MRG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

697303:THEWI RS02085
gene id: 697303:THEWI_RS02085
uniprot id: G2MW20
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

697303:THEWI RS00270
gene id: 697303:THEWI_RS00270
uniprot id: G2MUP4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

697303:THEWI RS00125
gene id: 697303:THEWI_RS00125
uniprot id: G2MUL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

697303:THEWI RS11565
gene id: 697303:THEWI_RS11565
uniprot id: G2MX36
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

697303:THEWI RS10075
gene id: 697303:THEWI_RS10075
uniprot id: G2MTD8
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

697303:THEWI RS07920
gene id: 697303:THEWI_RS07920
uniprot id: G2MTA3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

697303:THEWI RS11350
gene id: 697303:THEWI_RS11350
uniprot id: G2MWZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

697303:THEWI RS07685
gene id: 697303:THEWI_RS07685
uniprot id: G2MT63
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

697303:THEWI RS05750
gene id: 697303:THEWI_RS05750
uniprot id: G2MSZ2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

697303:THEWI RS02965
gene id: 697303:THEWI_RS02965
uniprot id: G2MS26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

697303:THEWI RS01155
gene id: 697303:THEWI_RS01155
uniprot id: G2MRY3
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

697303:THEWI RS03605
gene id: 697303:THEWI_RS03605
uniprot id: G2MSW0
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

697303:THEWI RS08080
gene id: 697303:THEWI_RS08080
uniprot id: G2MTL3
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

697303:THEWI RS13280
gene id: 697303:THEWI_RS13280
uniprot id: G2MUG0
names: Similarity
messages: Belongs to the PspA/IM30 family.

697303:THEWI RS03910
gene id: 697303:THEWI_RS03910
uniprot id: G2MV51
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

697303:THEWI RS04790
gene id: 697303:THEWI_RS04790
uniprot id: G2MXB1
names: Similarity
messages: Belongs to the transglycosylase Slt family.

697303:THEWI RS05850
gene id: 697303:THEWI_RS05850
uniprot id: G2MT13
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

697303:THEWI RS08525
gene id: 697303:THEWI_RS08525
uniprot id: G2MVH6
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

697303:THEWI RS13300
gene id: 697303:THEWI_RS13300
uniprot id: G2MUG3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

697303:THEWI RS11235
gene id: 697303:THEWI_RS11235
uniprot id: G2MWW9
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

697303:THEWI RS01960
gene id: 697303:THEWI_RS01960
uniprot id: G2MUY2
names: Similarity
messages: Belongs to the CapA family.

697303:THEWI RS01925
gene id: 697303:THEWI_RS01925
uniprot id: G2MUX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

697303:THEWI RS05820
gene id: 697303:THEWI_RS05820
uniprot id: G2MT07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

697303:THEWI RS06555
gene id: 697303:THEWI_RS06555
uniprot id: G2MWJ3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

697303:THEWI RS04235
gene id: 697303:THEWI_RS04235
uniprot id: G2MWC1
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS06755
gene id: 697303:THEWI_RS06755
uniprot id: G2MWN2
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS03025
gene id: 697303:THEWI_RS03025
uniprot id: G2MS38
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

697303:THEWI RS05260
gene id: 697303:THEWI_RS05260
uniprot id: G2MS95
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

697303:THEWI RS07015
gene id: 697303:THEWI_RS07015
uniprot id: G2MXG2
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

697303:THEWI RS00745
gene id: 697303:THEWI_RS00745
uniprot id: G2MVY9
names: Similarity
messages: Belongs to the acylphosphatase family.
messages: Belongs to the carbamoyltransferase HypF family.

697303:THEWI RS06575
gene id: 697303:THEWI_RS06575
uniprot id: G2MWJ7
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

697303:THEWI RS08420
gene id: 697303:THEWI_RS08420
uniprot id: G2MVF5
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

697303:THEWI RS05515
gene id: 697303:THEWI_RS05515
uniprot id: G2MSE1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

697303:THEWI RS11175
gene id: 697303:THEWI_RS11175
uniprot id: G2MVT3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

697303:THEWI RS11665
gene id: 697303:THEWI_RS11665
uniprot id: G2MXT4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

697303:THEWI RS11215
gene id: 697303:THEWI_RS11215
uniprot id: G2MWW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

697303:THEWI RS06100
gene id: 697303:THEWI_RS06100
uniprot id: G2MV93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

697303:THEWI RS05865
gene id: 697303:THEWI_RS05865
uniprot id: G2MT16
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

697303:THEWI RS07635
gene id: 697303:THEWI_RS07635
uniprot id: G2MT53
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS06185
gene id: 697303:THEWI_RS06185
uniprot id: G2MVB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

697303:THEWI RS11675
gene id: 697303:THEWI_RS11675
uniprot id: G2MXT6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

697303:THEWI RS01865
gene id: 697303:THEWI_RS01865
uniprot id: G2MUW4
names: Similarity
messages: Belongs to the transposase IS21/IS408/IS1162 family.

697303:THEWI RS09055
gene id: 697303:THEWI_RS09055
uniprot id: G2MWU7
names: Function
names: Subcellular Location Annotation
messages: Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-exporting P-type ATPase A (CopA).
messages: Cytoplasm

697303:THEWI RS06495
gene id: 697303:THEWI_RS06495
uniprot id: G2MWI1
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

697303:THEWI RS06970
gene id: 697303:THEWI_RS06970
uniprot id: G2MXF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CodY family.
messages: Cytoplasm
messages: DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability. During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion.

697303:THEWI RS12620
gene id: 697303:THEWI_RS12620
uniprot id: G2MU30
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

697303:THEWI RS13530
gene id: 697303:THEWI_RS13530
uniprot id: G2MUK1
names: Similarity
messages: Belongs to the ParB family.

697303:THEWI RS06235
gene id: 697303:THEWI_RS06235
uniprot id: G2MVC0
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cytoplasm
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

697303:THEWI RS12570
gene id: 697303:THEWI_RS12570
uniprot id: G2MU23
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

697303:THEWI RS03285
gene id: 697303:THEWI_RS03285
uniprot id: G2MSQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

697303:THEWI RS03380
gene id: 697303:THEWI_RS03380
uniprot id: G2MSS5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

697303:THEWI RS08165
gene id: 697303:THEWI_RS08165
uniprot id: G2MTM9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.

697303:THEWI RS10975
gene id: 697303:THEWI_RS10975
uniprot id: G2MVQ5
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

697303:THEWI RS13130
gene id: 697303:THEWI_RS13130
uniprot id: G2MUD0
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

697303:THEWI RS01940
gene id: 697303:THEWI_RS01940
uniprot id: G2MUX8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport.

697303:THEWI RS03475
gene id: 697303:THEWI_RS03475
uniprot id: G2MSU4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

697303:THEWI RS07425
gene id: 697303:THEWI_RS07425
uniprot id: G2MRB4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

697303:THEWI RS01460
gene id: 697303:THEWI_RS01460
uniprot id: G2MSL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for D-xylose. Probably responsible for the translocation of the substrate across the membrane.

697303:THEWI RS06405
gene id: 697303:THEWI_RS06405
uniprot id: G2MWG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

697303:THEWI RS02890
gene id: 697303:THEWI_RS02890
uniprot id: G2MS11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS12545
gene id: 697303:THEWI_RS12545
uniprot id: G2MU18
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

697303:THEWI RS01770
gene id: 697303:THEWI_RS01770
uniprot id: G2MUU5
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

697303:THEWI RS10210
gene id: 697303:THEWI_RS10210
uniprot id: G2MTG4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

697303:THEWI RS09065
gene id: 697303:THEWI_RS09065
uniprot id: G2MWU9
names: Similarity
messages: Belongs to the UPF0251 family.

697303:THEWI RS10355
gene id: 697303:THEWI_RS10355
uniprot id: G2MTR4
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS02205
gene id: 697303:THEWI_RS02205
uniprot id: G2MW39
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

697303:THEWI RS02875
gene id: 697303:THEWI_RS02875
uniprot id: G2MS08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

697303:THEWI RS06785
gene id: 697303:THEWI_RS06785
uniprot id: G2MXB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

697303:THEWI RS08185
gene id: 697303:THEWI_RS08185
uniprot id: G2MTN2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

697303:THEWI RS13055
gene id: 697303:THEWI_RS13055
uniprot id: G2MUB6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

697303:THEWI RS04270
gene id: 697303:THEWI_RS04270
uniprot id: G2MWC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

697303:THEWI RS03275
gene id: 697303:THEWI_RS03275
uniprot id: G2MSQ4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

697303:THEWI RS03650
gene id: 697303:THEWI_RS03650
uniprot id: G2MV05
names: Similarity
messages: Belongs to the leucine-binding protein family.

697303:THEWI RS12825
gene id: 697303:THEWI_RS12825
uniprot id: G2MU71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

697303:THEWI RS09630
gene id: 697303:THEWI_RS09630
uniprot id: G2MRF5
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
messages: Belongs to the biotin--protein ligase family.

697303:THEWI RS06915
gene id: 697303:THEWI_RS06915
uniprot id: G2MXE2
names: Similarity
messages: Belongs to the FlgD family.

697303:THEWI RS05350
gene id: 697303:THEWI_RS05350
uniprot id: G2MSB1
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

697303:THEWI RS06895
gene id: 697303:THEWI_RS06895
uniprot id: G2MXD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

697303:THEWI RS02060
gene id: 697303:THEWI_RS02060
uniprot id: G2MW15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

697303:THEWI RS06285
gene id: 697303:THEWI_RS06285
uniprot id: G2MVD1
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

697303:THEWI RS00810
gene id: 697303:THEWI_RS00810
uniprot id: G2MW02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

697303:THEWI RS03050
gene id: 697303:THEWI_RS03050
uniprot id: G2MS44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

697303:THEWI RS06935
gene id: 697303:THEWI_RS06935
uniprot id: G2MXE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cytoplasm

697303:THEWI RS11740
gene id: 697303:THEWI_RS11740
uniprot id: G2MXU9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
messages: Cytoplasm
messages: Homotetramer.

697303:THEWI RS12970
gene id: 697303:THEWI_RS12970
uniprot id: G2MUA1
names: Similarity
messages: Belongs to the peptidase S8 family.

697303:THEWI RS00595
gene id: 697303:THEWI_RS00595
uniprot id: G2MVV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arginine deiminase family.
messages: Cytoplasm

697303:THEWI RS02510
gene id: 697303:THEWI_RS02510
uniprot id: G2MQS7
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS03180
gene id: 697303:THEWI_RS03180
uniprot id: G2MS71
names: Function
names: Similarity
names: Subunit
messages: Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization.
messages: Belongs to the HutP family.
messages: Homohexamer.

697303:THEWI RS13470
gene id: 697303:THEWI_RS13470
uniprot id: G2MUJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

697303:THEWI RS06750
gene id: 697303:THEWI_RS06750
uniprot id: G2MWN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

697303:THEWI RS01540
gene id: 697303:THEWI_RS01540
uniprot id: G2MSN0
names: Subcellular Location Annotation
messages: Cytoplasm

697303:THEWI RS10090
gene id: 697303:THEWI_RS10090
uniprot id: G2MTE1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

697303:THEWI RS07175
gene id: 697303:THEWI_RS07175
uniprot id: G2MR67
names: Function
names: Similarity
messages: Belongs to the alpha/beta-type SASP family.
messages: SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.

697303:THEWI RS11560
gene id: 697303:THEWI_RS11560
uniprot id: G2MX35
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

697303:THEWI RS04935
gene id: 697303:THEWI_RS04935
uniprot id: G2MR17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

697303:THEWI RS09595
gene id: 697303:THEWI_RS09595
uniprot id: G2MRE8
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

697303:THEWI RS09465
gene id: 697303:THEWI_RS09465
uniprot id: G2MXQ6
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

697303:THEWI RS02950
gene id: 697303:THEWI_RS02950
uniprot id: G2MS23
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

697303:THEWI RS07140
gene id: 697303:THEWI_RS07140
uniprot id: G2MXI7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

697303:THEWI RS00515
gene id: 697303:THEWI_RS00515
uniprot id: G2MVU3
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

697303:THEWI RS12490
gene id: 697303:THEWI_RS12490
uniprot id: G2MU07
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS06670
gene id: 697303:THEWI_RS06670
uniprot id: G2MWL5
names: Similarity
messages: Belongs to the peptidase M16 family.

697303:THEWI RS10140
gene id: 697303:THEWI_RS10140
uniprot id: G2MTF1
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS09235
gene id: 697303:THEWI_RS09235
uniprot id: G2MXL2
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

697303:THEWI RS10015
gene id: 697303:THEWI_RS10015
uniprot id: G2MTC6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

697303:THEWI RS04165
gene id: 697303:THEWI_RS04165
uniprot id: G2MWA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

697303:THEWI RS07190
gene id: 697303:THEWI_RS07190
uniprot id: G2MR70
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

697303:THEWI RS07305
gene id: 697303:THEWI_RS07305
uniprot id: G2MR93
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

697303:THEWI RS01270
gene id: 697303:THEWI_RS01270
uniprot id: G2MSH6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

697303:THEWI RS11420
gene id: 697303:THEWI_RS11420
uniprot id: G2MX06
names: Similarity
messages: Belongs to the ycf81 family.

697303:THEWI RS00195
gene id: 697303:THEWI_RS00195
uniprot id: G2MUN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit C family.
messages: Membrane

697303:THEWI RS13475
gene id: 697303:THEWI_RS13475
uniprot id: G2MUJ1
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

697303:THEWI RS11670
gene id: 697303:THEWI_RS11670
uniprot id: G2MXT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

697303:THEWI RS02885
gene id: 697303:THEWI_RS02885
uniprot id: G2MS10
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

697303:THEWI RS03415
gene id: 697303:THEWI_RS03415
uniprot id: G2MST2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

697303:THEWI RS02415
gene id: 697303:THEWI_RS02415
uniprot id: G2MW73
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

697303:THEWI RS04250
gene id: 697303:THEWI_RS04250
uniprot id: G2MWC4
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

697303:THEWI RS02210
gene id: 697303:THEWI_RS02210
uniprot id: G2MW40
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

697303:THEWI RS07295
gene id: 697303:THEWI_RS07295
uniprot id: G2MR91
names: Similarity
messages: Belongs to the YicC/YloC family.

697303:THEWI RS02770
gene id: 697303:THEWI_RS02770
uniprot id: G2MQX4
names: Similarity
messages: Belongs to the bacterial flagellin family.

697303:THEWI RS07585
gene id: 697303:THEWI_RS07585
uniprot id: G2MT43
names: Similarity
messages: Belongs to the TrpF family.

697303:THEWI RS11605
gene id: 697303:THEWI_RS11605
uniprot id: G2MXS2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

697303:THEWI RS10230
gene id: 697303:THEWI_RS10230
uniprot id: G2MTG8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

697303:THEWI RS03030
gene id: 697303:THEWI_RS03030
uniprot id: G2MS39
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

697303:THEWI RS12510
gene id: 697303:THEWI_RS12510
uniprot id: G2MU11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

697303:THEWI RS00920
gene id: 697303:THEWI_RS00920
uniprot id: G2MRT9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS11635
gene id: 697303:THEWI_RS11635
uniprot id: G2MXS8
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

697303:THEWI RS05550
gene id: 697303:THEWI_RS05550
uniprot id: G2MSE9
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

697303:THEWI RS12975
gene id: 697303:THEWI_RS12975
uniprot id: G2MUA2
names: Similarity
messages: Belongs to the peptidase S41A family.

697303:THEWI RS02215
gene id: 697303:THEWI_RS02215
uniprot id: G2MW41
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
messages: Homooctamer.

697303:THEWI RS05150
gene id: 697303:THEWI_RS05150
uniprot id: G2MR57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

697303:THEWI RS03140
gene id: 697303:THEWI_RS03140
uniprot id: G2MS62
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

697303:THEWI RS01145
gene id: 697303:THEWI_RS01145
uniprot id: G2MRY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS07390
gene id: 697303:THEWI_RS07390
uniprot id: G2MRA7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

697303:THEWI RS05465
gene id: 697303:THEWI_RS05465
uniprot id: G2MSD1
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS00705
gene id: 697303:THEWI_RS00705
uniprot id: G2MVY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family.
messages: Membrane

697303:THEWI RS13050
gene id: 697303:THEWI_RS13050
uniprot id: G2MUB5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

697303:THEWI RS03915
gene id: 697303:THEWI_RS03915
uniprot id: G2MV52
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

697303:THEWI RS07410
gene id: 697303:THEWI_RS07410
uniprot id: G2MRB1
names: Function
names: Similarity
names: Subunit
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Homodimer and homohexamer; in equilibrium.
messages: Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.

697303:THEWI RS06220
gene id: 697303:THEWI_RS06220
uniprot id: G2MVB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

697303:THEWI RS00940
gene id: 697303:THEWI_RS00940
uniprot id: G2MRU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

697303:THEWI RS09045
gene id: 697303:THEWI_RS09045
uniprot id: G2MWU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

697303:THEWI RS06890
gene id: 697303:THEWI_RS06890
uniprot id: G2MXD7
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Membrane

697303:THEWI RS06860
gene id: 697303:THEWI_RS06860
uniprot id: G2MXD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

697303:THEWI RS11010
gene id: 697303:THEWI_RS11010
uniprot id: G2MVR2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

697303:THEWI RS07200
gene id: 697303:THEWI_RS07200
uniprot id: G2MR72
names: Similarity
messages: Belongs to the asp23 family.

697303:THEWI RS07405
gene id: 697303:THEWI_RS07405
uniprot id: G2MRB0
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

697303:THEWI RS12385
gene id: 697303:THEWI_RS12385
uniprot id: G2MTY7
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

697303:THEWI RS09715
gene id: 697303:THEWI_RS09715
uniprot id: G2MRH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

697303:THEWI RS04840
gene id: 697303:THEWI_RS04840
uniprot id: G2MQZ8
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

697303:THEWI RS11155
gene id: 697303:THEWI_RS11155
uniprot id: G2MVS9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

697303:THEWI RS03385
gene id: 697303:THEWI_RS03385
uniprot id: G2MSS6
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

697303:THEWI RS01250
gene id: 697303:THEWI_RS01250
uniprot id: G2MS02
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS12980
gene id: 697303:THEWI_RS12980
uniprot id: G2MUA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

697303:THEWI RS13480
gene id: 697303:THEWI_RS13480
uniprot id: G2MUJ2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

697303:THEWI RS09050
gene id: 697303:THEWI_RS09050
uniprot id: G2MWU5
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

697303:THEWI RS12985
gene id: 697303:THEWI_RS12985
uniprot id: G2MUA4
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

697303:THEWI RS07885
gene id: 697303:THEWI_RS07885
uniprot id: G2MT96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

697303:THEWI RS01820
gene id: 697303:THEWI_RS01820
uniprot id: G2MUV5
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.
messages: Homotetramer.

697303:THEWI RS12360
gene id: 697303:THEWI_RS12360
uniprot id: G2MRS9
names: Subcellular Location Annotation
messages: Nucleus

697303:THEWI RS10305
gene id: 697303:THEWI_RS10305
uniprot id: G2MTI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

697303:THEWI RS07795
gene id: 697303:THEWI_RS07795
uniprot id: G2MT82
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS08435
gene id: 697303:THEWI_RS08435
uniprot id: G2MVF8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

697303:THEWI RS05955
gene id: 697303:THEWI_RS05955
uniprot id: G2MT34
names: Similarity
messages: Belongs to the UPF0297 family.

697303:THEWI RS09240
gene id: 697303:THEWI_RS09240
uniprot id: G2MXL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 32 family.
messages: Cytoplasm
messages: Enables the bacterium to metabolize sucrose as a sole carbon source.

697303:THEWI RS04480
gene id: 697303:THEWI_RS04480
uniprot id: G2MX51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S8 family.
messages: Monomer.
messages: Serine protease with a broad substrate specificity.

697303:THEWI RS00085
gene id: 697303:THEWI_RS00085
uniprot id: G2MSH2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

697303:THEWI RS04540
gene id: 697303:THEWI_RS04540
uniprot id: G2MX63
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS08315
gene id: 697303:THEWI_RS08315
uniprot id: G2MTQ3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class U subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.

697303:THEWI RS05840
gene id: 697303:THEWI_RS05840
uniprot id: G2MT11
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS10800
gene id: 697303:THEWI_RS10800
uniprot id: G2MVM3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

697303:THEWI RS02995
gene id: 697303:THEWI_RS02995
uniprot id: G2MS32
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

697303:THEWI RS07335
gene id: 697303:THEWI_RS07335
uniprot id: G2MR99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS06580
gene id: 697303:THEWI_RS06580
uniprot id: G2MWJ8
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

697303:THEWI RS03470
gene id: 697303:THEWI_RS03470
uniprot id: G2MSU3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

697303:THEWI RS09790
gene id: 697303:THEWI_RS09790
uniprot id: G2MRI3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

697303:THEWI RS00700
gene id: 697303:THEWI_RS00700
uniprot id: G2MVY0
names: Similarity
messages: Belongs to the AAA ATPase family.
messages: In the C-terminal section; belongs to the peptidase M41 family.

697303:THEWI RS03545
gene id: 697303:THEWI_RS03545
uniprot id: G2MSU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS03900
gene id: 697303:THEWI_RS03900
uniprot id: G2MV49
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

697303:THEWI RS06705
gene id: 697303:THEWI_RS06705
uniprot id: G2MWM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

697303:THEWI RS11590
gene id: 697303:THEWI_RS11590
uniprot id: G2MXR9
names: Similarity
messages: Belongs to the GerABKC lipoprotein family.

697303:THEWI RS11415
gene id: 697303:THEWI_RS11415
uniprot id: G2MX05
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

697303:THEWI RS08665
gene id: 697303:THEWI_RS08665
uniprot id: G2MVK0
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

697303:THEWI RS11630
gene id: 697303:THEWI_RS11630
uniprot id: G2MXS7
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

697303:THEWI RS06730
gene id: 697303:THEWI_RS06730
uniprot id: G2MWM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

697303:THEWI RS13135
gene id: 697303:THEWI_RS13135
uniprot id: G2MUD1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Heptamer of 7 subunits arranged in a ring.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

697303:THEWI RS08160
gene id: 697303:THEWI_RS08160
uniprot id: G2MTM8
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

697303:THEWI RS10450
gene id: 697303:THEWI_RS10450
uniprot id: G2MTS8
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

697303:THEWI RS11335
gene id: 697303:THEWI_RS11335
uniprot id: G2MWY9
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

697303:THEWI RS11210
gene id: 697303:THEWI_RS11210
uniprot id: G2MWW4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

697303:THEWI RS09435
gene id: 697303:THEWI_RS09435
uniprot id: G2MXQ0
names: Function
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.
messages: Transcriptional repressor of xylose-utilizing enzymes.

697303:THEWI RS03625
gene id: 697303:THEWI_RS03625
uniprot id: G2MV00
names: Cofactor
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: Binds 1 Mg(2+) ion per subunit.

697303:THEWI RS08000
gene id: 697303:THEWI_RS08000
uniprot id: G2MTJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

697303:THEWI RS11325
gene id: 697303:THEWI_RS11325
uniprot id: G2MWY7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

697303:THEWI RS04230
gene id: 697303:THEWI_RS04230
uniprot id: G2MWC0
names: Similarity
messages: Belongs to the UDPGP type 2 family.

697303:THEWI RS03015
gene id: 697303:THEWI_RS03015
uniprot id: G2MS36
names: Similarity
messages: Belongs to the MotB family.

697303:THEWI RS00390
gene id: 697303:THEWI_RS00390
uniprot id: G2MUR1
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

697303:THEWI RS05825
gene id: 697303:THEWI_RS05825
uniprot id: G2MT08
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

697303:THEWI RS08615
gene id: 697303:THEWI_RS08615
uniprot id: G2MVJ0
names: Similarity
messages: Belongs to the UxaA family.

697303:THEWI RS06710
gene id: 697303:THEWI_RS06710
uniprot id: G2MWM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

697303:THEWI RS00630
gene id: 697303:THEWI_RS00630
uniprot id: G2MVW6
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

697303:THEWI RS08980
gene id: 697303:THEWI_RS08980
uniprot id: G2MWT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

697303:THEWI RS05160
gene id: 697303:THEWI_RS05160
uniprot id: G2MR59
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

697303:THEWI RS00120
gene id: 697303:THEWI_RS00120
uniprot id: G2MUL7
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

697303:THEWI RS05615
gene id: 697303:THEWI_RS05615
uniprot id: G2MSW9
names: Similarity
messages: Belongs to the thioredoxin family.

697303:THEWI RS11950
gene id: 697303:THEWI_RS11950
uniprot id: G2MXY8
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

697303:THEWI RS14020
gene id: 697303:THEWI_RS14020
uniprot id: G2MX27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0291 family.
messages: Cytoplasm

697303:THEWI RS03540
gene id: 697303:THEWI_RS03540
uniprot id: G2MSU8
names: Similarity
messages: Belongs to the glutamine synthetase family.

697303:THEWI RS07145
gene id: 697303:THEWI_RS07145
uniprot id: G2MXI8
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

697303:THEWI RS01900
gene id: 697303:THEWI_RS01900
uniprot id: G2MUX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

697303:THEWI RS12480
gene id: 697303:THEWI_RS12480
uniprot id: G2MU05
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

697303:THEWI RS12960
gene id: 697303:THEWI_RS12960
uniprot id: G2MU99
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

697303:THEWI RS07985
gene id: 697303:THEWI_RS07985
uniprot id: G2MTJ4
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS07990
gene id: 697303:THEWI_RS07990
uniprot id: G2MTJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

697303:THEWI RS01010
gene id: 697303:THEWI_RS01010
uniprot id: G2MRV6
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS12885
gene id: 697303:THEWI_RS12885
uniprot id: G2MU83
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

697303:THEWI RS07495
gene id: 697303:THEWI_RS07495
uniprot id: G2MRC3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

697303:THEWI RS06325
gene id: 697303:THEWI_RS06325
uniprot id: G2MVD9
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

697303:THEWI RS02555
gene id: 697303:THEWI_RS02555
uniprot id: G2MQT6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

697303:THEWI RS04865
gene id: 697303:THEWI_RS04865
uniprot id: G2MR03
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS01220
gene id: 697303:THEWI_RS01220
uniprot id: G2MRZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

697303:THEWI RS01785
gene id: 697303:THEWI_RS01785
uniprot id: G2MUU8
names: Similarity
messages: Belongs to the Tlp family.

697303:THEWI RS09675
gene id: 697303:THEWI_RS09675
uniprot id: G2MRG4
names: Similarity
messages: Belongs to the peptidase S41A family.

697303:THEWI RS08385
gene id: 697303:THEWI_RS08385
uniprot id: G2MVF0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
messages: Homohexamer; trimer of homodimers.

697303:THEWI RS01000
gene id: 697303:THEWI_RS01000
uniprot id: G2MRV4
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

697303:THEWI RS00520
gene id: 697303:THEWI_RS00520
uniprot id: G2MVU4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

697303:THEWI RS13070
gene id: 697303:THEWI_RS13070
uniprot id: G2MUB9
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

697303:THEWI RS05155
gene id: 697303:THEWI_RS05155
uniprot id: G2MR58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

697303:THEWI RS00040
gene id: 697303:THEWI_RS00040
uniprot id: G2MSG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MurCDEF family. MurT subfamily.
messages: Forms a heterodimer with GatD.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.

697303:THEWI RS10945
gene id: 697303:THEWI_RS10945
uniprot id: G2MVQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CotF family.
messages: Spore coat

697303:THEWI RS06170
gene id: 697303:THEWI_RS06170
uniprot id: G2MVA7
names: Similarity
messages: Belongs to the asp23 family.

697303:THEWI RS06865
gene id: 697303:THEWI_RS06865
uniprot id: G2MXD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

697303:THEWI RS09920
gene id: 697303:THEWI_RS09920
uniprot id: G2MRK1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

697303:THEWI RS05285
gene id: 697303:THEWI_RS05285
uniprot id: G2MSA0
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

697303:THEWI RS12520
gene id: 697303:THEWI_RS12520
uniprot id: G2MU13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

697303:THEWI RS00770
gene id: 697303:THEWI_RS00770
uniprot id: G2MVZ4
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

697303:THEWI RS13335
gene id: 697303:THEWI_RS13335
uniprot id: G2MSQ3
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

697303:THEWI RS06745
gene id: 697303:THEWI_RS06745
uniprot id: G2MWN0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

697303:THEWI RS02860
gene id: 697303:THEWI_RS02860
uniprot id: G2MS05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

697303:THEWI RS01280
gene id: 697303:THEWI_RS01280
uniprot id: G2MSH8
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

697303:THEWI RS05485
gene id: 697303:THEWI_RS05485
uniprot id: G2MSD5
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

697303:THEWI RS01125
gene id: 697303:THEWI_RS01125
uniprot id: G2MRX8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

697303:THEWI RS10255
gene id: 697303:THEWI_RS10255
uniprot id: G2MTH3
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 26 family. TagA/TarA subfamily.
messages: Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid.

697303:THEWI RS04550
gene id: 697303:THEWI_RS04550
uniprot id: G2MX65
names: Similarity
messages: Belongs to the glutamine synthetase family.

697303:THEWI RS11735
gene id: 697303:THEWI_RS11735
uniprot id: G2MXU8
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

697303:THEWI RS07060
gene id: 697303:THEWI_RS07060
uniprot id: G2MXH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

697303:THEWI RS05980
gene id: 697303:THEWI_RS05980
uniprot id: G2MT39
names: Similarity
messages: Belongs to the UPF0342 family.

697303:THEWI RS10575
gene id: 697303:THEWI_RS10575
uniprot id: G2MTU8
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS12865
gene id: 697303:THEWI_RS12865
uniprot id: G2MU79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

697303:THEWI RS00925
gene id: 697303:THEWI_RS00925
uniprot id: G2MRU0
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

697303:THEWI RS02475
gene id: 697303:THEWI_RS02475
uniprot id: G2MQS1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

697303:THEWI RS11440
gene id: 697303:THEWI_RS11440
uniprot id: G2MX10
names: Similarity
messages: Belongs to the DtxR/MntR family.

697303:THEWI RS08770
gene id: 697303:THEWI_RS08770
uniprot id: G2MWN9
names: Function
names: Similarity
names: Subunit
messages: Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization.
messages: Belongs to the HutP family.
messages: Homohexamer.

697303:THEWI RS02065
gene id: 697303:THEWI_RS02065
uniprot id: G2MW16
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

697303:THEWI RS10825
gene id: 697303:THEWI_RS10825
uniprot id: G2MVM8
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

697303:THEWI RS02640
gene id: 697303:THEWI_RS02640
uniprot id: G2MQV1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

697303:THEWI RS02930
gene id: 697303:THEWI_RS02930
uniprot id: G2MS19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

697303:THEWI RS00945
gene id: 697303:THEWI_RS00945
uniprot id: G2MRU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

697303:THEWI RS03310
gene id: 697303:THEWI_RS03310
uniprot id: G2MSR1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

697303:THEWI RS07400
gene id: 697303:THEWI_RS07400
uniprot id: G2MRA9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS03055
gene id: 697303:THEWI_RS03055
uniprot id: G2MS45
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

697303:THEWI RS11190
gene id: 697303:THEWI_RS11190
uniprot id: G2MWW0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

697303:THEWI RS07005
gene id: 697303:THEWI_RS07005
uniprot id: G2MXG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

697303:THEWI RS11490
gene id: 697303:THEWI_RS11490
uniprot id: G2MX20
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

697303:THEWI RS02575
gene id: 697303:THEWI_RS02575
uniprot id: G2MQU0
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS13175
gene id: 697303:THEWI_RS13175
uniprot id: G2MUD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

697303:THEWI RS03670
gene id: 697303:THEWI_RS03670
uniprot id: G2MV08
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

697303:THEWI RS05870
gene id: 697303:THEWI_RS05870
uniprot id: G2MT17
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS09460
gene id: 697303:THEWI_RS09460
uniprot id: G2MXQ5
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

697303:THEWI RS01425
gene id: 697303:THEWI_RS01425
uniprot id: G2MSK7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS13165
gene id: 697303:THEWI_RS13165
uniprot id: G2MUD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

697303:THEWI RS08970
gene id: 697303:THEWI_RS08970
uniprot id: G2MWS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Cell membrane

697303:THEWI RS02440
gene id: 697303:THEWI_RS02440
uniprot id: G2MW77
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

697303:THEWI RS09000
gene id: 697303:THEWI_RS09000
uniprot id: G2MWT6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS07590
gene id: 697303:THEWI_RS07590
uniprot id: G2MT44
names: Similarity
messages: Belongs to the TrpC family.

697303:THEWI RS11150
gene id: 697303:THEWI_RS11150
uniprot id: G2MVS8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

697303:THEWI RS05250
gene id: 697303:THEWI_RS05250
uniprot id: G2MS93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

697303:THEWI RS07815
gene id: 697303:THEWI_RS07815
uniprot id: G2MT84
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

697303:THEWI RS05495
gene id: 697303:THEWI_RS05495
uniprot id: G2MSD7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS05300
gene id: 697303:THEWI_RS05300
uniprot id: G2MSA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

697303:THEWI RS01850
gene id: 697303:THEWI_RS01850
uniprot id: G2MUW1
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

697303:THEWI RS12280
gene id: 697303:THEWI_RS12280
uniprot id: G2MRR7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

697303:THEWI RS03995
gene id: 697303:THEWI_RS03995
uniprot id: G2MV66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

697303:THEWI RS09575
gene id: 697303:THEWI_RS09575
uniprot id: G2MRE4
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

697303:THEWI RS05710
gene id: 697303:THEWI_RS05710
uniprot id: G2MSY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS08410
gene id: 697303:THEWI_RS08410
uniprot id: G2MVF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

697303:THEWI RS10085
gene id: 697303:THEWI_RS10085
uniprot id: G2MTE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

697303:THEWI RS05025
gene id: 697303:THEWI_RS05025
uniprot id: G2MR34
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

697303:THEWI RS07090
gene id: 697303:THEWI_RS07090
uniprot id: G2MXH7
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

697303:THEWI RS02025
gene id: 697303:THEWI_RS02025
uniprot id: G2MUZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS05255
gene id: 697303:THEWI_RS05255
uniprot id: G2MS94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

697303:THEWI RS05695
gene id: 697303:THEWI_RS05695
uniprot id: G2MSY2
names: Similarity
messages: Belongs to the IMPACT family.

697303:THEWI RS01680
gene id: 697303:THEWI_RS01680
uniprot id: G2MUT1
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS05965
gene id: 697303:THEWI_RS05965
uniprot id: G2MT36
names: Similarity
messages: Belongs to the UPF0473 family.

697303:THEWI RS07095
gene id: 697303:THEWI_RS07095
uniprot id: G2MXH8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

697303:THEWI RS08310
gene id: 697303:THEWI_RS08310
uniprot id: G2MTQ2
names: Subcellular Location Annotation
messages: Cytoplasm

697303:THEWI RS00995
gene id: 697303:THEWI_RS00995
uniprot id: G2MRV3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

697303:THEWI RS09405
gene id: 697303:THEWI_RS09405
uniprot id: G2MXP4
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

697303:THEWI RS08450
gene id: 697303:THEWI_RS08450
uniprot id: G2MVG1
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

697303:THEWI RS12305
gene id: 697303:THEWI_RS12305
uniprot id: G2MRS2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

697303:THEWI RS09250
gene id: 697303:THEWI_RS09250
uniprot id: G2MXL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS04970
gene id: 697303:THEWI_RS04970
uniprot id: G2MR23
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

697303:THEWI RS09710
gene id: 697303:THEWI_RS09710
uniprot id: G2MRH2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

697303:THEWI RS12515
gene id: 697303:THEWI_RS12515
uniprot id: G2MU12
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

697303:THEWI RS02040
gene id: 697303:THEWI_RS02040
uniprot id: G2MUZ8
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

697303:THEWI RS09490
gene id: 697303:THEWI_RS09490
uniprot id: G2MXR1
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS12735
gene id: 697303:THEWI_RS12735
uniprot id: G2MU53
names: Function
names: Similarity
messages: Belongs to the alpha/beta-type SASP family.
messages: SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.

697303:THEWI RS12990
gene id: 697303:THEWI_RS12990
uniprot id: G2MUA5
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

697303:THEWI RS05790
gene id: 697303:THEWI_RS05790
uniprot id: G2MT01
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

697303:THEWI RS10045
gene id: 697303:THEWI_RS10045
uniprot id: G2MTD3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

697303:THEWI RS05585
gene id: 697303:THEWI_RS05585
uniprot id: G2MSW4
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS13170
gene id: 697303:THEWI_RS13170
uniprot id: G2MUD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

697303:THEWI RS03600
gene id: 697303:THEWI_RS03600
uniprot id: G2MSV9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

697303:THEWI RS12840
gene id: 697303:THEWI_RS12840
uniprot id: G2MU74
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

697303:THEWI RS12765
gene id: 697303:THEWI_RS12765
uniprot id: G2MU59
names: Similarity
messages: Belongs to the GerABKA family.

697303:THEWI RS00870
gene id: 697303:THEWI_RS00870
uniprot id: G2MRT0
names: Cofactor
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: Binds 1 Mg(2+) ion per subunit.

697303:THEWI RS07840
gene id: 697303:THEWI_RS07840
uniprot id: G2MT87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

697303:THEWI RS06525
gene id: 697303:THEWI_RS06525
uniprot id: G2MWI7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

697303:THEWI RS00185
gene id: 697303:THEWI_RS00185
uniprot id: G2MUM8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

697303:THEWI RS01725
gene id: 697303:THEWI_RS01725
uniprot id: G2MUT6
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

697303:THEWI RS11715
gene id: 697303:THEWI_RS11715
uniprot id: G2MXU3
names: Similarity
messages: Belongs to the zinc-associated anti-sigma factor (ZAS) superfamily. Anti-sigma-W factor family.

697303:THEWI RS06685
gene id: 697303:THEWI_RS06685
uniprot id: G2MWL8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

697303:THEWI RS08205
gene id: 697303:THEWI_RS08205
uniprot id: G2MTN6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

697303:THEWI RS07580
gene id: 697303:THEWI_RS07580
uniprot id: G2MT42
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

697303:THEWI RS10250
gene id: 697303:THEWI_RS10250
uniprot id: G2MTH2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

697303:THEWI RS08925
gene id: 697303:THEWI_RS08925
uniprot id: G2MWS0
names: Function
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.

697303:THEWI RS00225
gene id: 697303:THEWI_RS00225
uniprot id: G2MUN6
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

697303:THEWI RS13100
gene id: 697303:THEWI_RS13100
uniprot id: G2MUC4
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

697303:THEWI RS08465
gene id: 697303:THEWI_RS08465
uniprot id: G2MVG4
names: Similarity
messages: Belongs to the acylphosphatase family.

697303:THEWI RS04995
gene id: 697303:THEWI_RS04995
uniprot id: G2MR28
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

697303:THEWI RS11170
gene id: 697303:THEWI_RS11170
uniprot id: G2MVT2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

697303:THEWI RS02290
gene id: 697303:THEWI_RS02290
uniprot id: G2MW52
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS06725
gene id: 697303:THEWI_RS06725
uniprot id: G2MWM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

697303:THEWI RS12720
gene id: 697303:THEWI_RS12720
uniprot id: G2MU50
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

697303:THEWI RS07690
gene id: 697303:THEWI_RS07690
uniprot id: G2MT64
names: Cofactor
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.

697303:THEWI RS08015
gene id: 697303:THEWI_RS08015
uniprot id: G2MTK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsL family.
messages: Cell membrane
messages: Essential cell division protein.
messages: Membrane

697303:THEWI RS06965
gene id: 697303:THEWI_RS06965
uniprot id: G2MXF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

697303:THEWI RS11230
gene id: 697303:THEWI_RS11230
uniprot id: G2MWW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

697303:THEWI RS08840
gene id: 697303:THEWI_RS08840
uniprot id: G2MWQ5
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

697303:THEWI RS04960
gene id: 697303:THEWI_RS04960
uniprot id: G2MR21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

697303:THEWI RS00180
gene id: 697303:THEWI_RS00180
uniprot id: G2MUM7
names: Similarity
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit G family.

697303:THEWI RS10525
gene id: 697303:THEWI_RS10525
uniprot id: G2MTT9
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS04095
gene id: 697303:THEWI_RS04095
uniprot id: G2MW93
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

697303:THEWI RS13045
gene id: 697303:THEWI_RS13045
uniprot id: G2MUB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

697303:THEWI RS11750
gene id: 697303:THEWI_RS11750
uniprot id: G2MXV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

697303:THEWI RS11320
gene id: 697303:THEWI_RS11320
uniprot id: G2MWY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

697303:THEWI RS02960
gene id: 697303:THEWI_RS02960
uniprot id: G2MS25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arginine deiminase family.
messages: Cytoplasm

697303:THEWI RS08795
gene id: 697303:THEWI_RS08795
uniprot id: G2MWP6
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.

697303:THEWI RS13345
gene id: 697303:THEWI_RS13345
uniprot id: G2MUH2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

697303:THEWI RS00030
gene id: 697303:THEWI_RS00030
uniprot id: G2MSG1
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

697303:THEWI RS13445
gene id: 697303:THEWI_RS13445
uniprot id: G2MUI6
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

697303:THEWI RS06650
gene id: 697303:THEWI_RS06650
uniprot id: G2MWL1
names: Similarity
messages: Belongs to the peptidase S14 family.

697303:THEWI RS12685
gene id: 697303:THEWI_RS12685
uniprot id: G2MU43
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

697303:THEWI RS09740
gene id: 697303:THEWI_RS09740
uniprot id: G2MRH7
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

697303:THEWI RS01340
gene id: 697303:THEWI_RS01340
uniprot id: G2MSJ0
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

697303:THEWI RS10570
gene id: 697303:THEWI_RS10570
uniprot id: G2MTU7
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS05950
gene id: 697303:THEWI_RS05950
uniprot id: G2MT33
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

697303:THEWI RS01470
gene id: 697303:THEWI_RS01470
uniprot id: G2MSL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

697303:THEWI RS00385
gene id: 697303:THEWI_RS00385
uniprot id: G2MUR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS03930
gene id: 697303:THEWI_RS03930
uniprot id: G2MV55
names: Similarity
messages: Belongs to the SecB family.

697303:THEWI RS02165
gene id: 697303:THEWI_RS02165
uniprot id: G2MW35
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

697303:THEWI RS02275
gene id: 697303:THEWI_RS02275
uniprot id: G2MW50
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

697303:THEWI RS01760
gene id: 697303:THEWI_RS01760
uniprot id: G2MUU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

697303:THEWI RS12405
gene id: 697303:THEWI_RS12405
uniprot id: G2MTZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

697303:THEWI RS01870
gene id: 697303:THEWI_RS01870
uniprot id: G2MUW5
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

697303:THEWI RS11290
gene id: 697303:THEWI_RS11290
uniprot id: G2MWY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

697303:THEWI RS11110
gene id: 697303:THEWI_RS11110
uniprot id: G2MVS0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS00200
gene id: 697303:THEWI_RS00200
uniprot id: G2MUN1
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS02125
gene id: 697303:THEWI_RS02125
uniprot id: G2MW28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

697303:THEWI RS02035
gene id: 697303:THEWI_RS02035
uniprot id: G2MUZ7
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

697303:THEWI RS02655
gene id: 697303:THEWI_RS02655
uniprot id: G2MQV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Homotetramer composed of a dimer of dimers.

697303:THEWI RS01905
gene id: 697303:THEWI_RS01905
uniprot id: G2MUX2
names: Function
messages: May be involved in the biosynthesis of molybdopterin.

697303:THEWI RS09140
gene id: 697303:THEWI_RS09140
uniprot id: G2MXJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

697303:THEWI RS12845
gene id: 697303:THEWI_RS12845
uniprot id: G2MU75
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

697303:THEWI RS11240
gene id: 697303:THEWI_RS11240
uniprot id: G2MWX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

697303:THEWI RS07610
gene id: 697303:THEWI_RS07610
uniprot id: G2MT48
names: Similarity
messages: Belongs to the UPF0045 family.

697303:THEWI RS04465
gene id: 697303:THEWI_RS04465
uniprot id: G2MX48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS01915
gene id: 697303:THEWI_RS01915
uniprot id: G2MUX4
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
messages: May be involved in the biosynthesis of molybdopterin.

697303:THEWI RS07830
gene id: 697303:THEWI_RS07830
uniprot id: G2MT85
names: Function
names: Subcellular Location Annotation
messages: ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
messages: Cytoplasm

697303:THEWI RS00205
gene id: 697303:THEWI_RS00205
uniprot id: G2MUN2
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS09835
gene id: 697303:THEWI_RS09835
uniprot id: G2MRI8
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

697303:THEWI RS11385
gene id: 697303:THEWI_RS11385
uniprot id: G2MWZ9
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

697303:THEWI RS03320
gene id: 697303:THEWI_RS03320
uniprot id: G2MSR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

697303:THEWI RS04125
gene id: 697303:THEWI_RS04125
uniprot id: G2MW99
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

697303:THEWI RS04080
gene id: 697303:THEWI_RS04080
uniprot id: G2MW90
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

697303:THEWI RS06930
gene id: 697303:THEWI_RS06930
uniprot id: G2MXE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS00395
gene id: 697303:THEWI_RS00395
uniprot id: G2MUR2
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

697303:THEWI RS00215
gene id: 697303:THEWI_RS00215
uniprot id: G2MUN4
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

697303:THEWI RS07965
gene id: 697303:THEWI_RS07965
uniprot id: G2MTB2
names: Similarity
messages: Belongs to the UPF0749 family.

697303:THEWI RS04560
gene id: 697303:THEWI_RS04560
uniprot id: G2MX67
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M38 family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Carboxylation allows a single lysine to coordinate two zinc ions.
messages: Catalyzes the hydrolytic cleavage of a subset of L-isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation.
messages: Cytoplasm

697303:THEWI RS01140
gene id: 697303:THEWI_RS01140
uniprot id: G2MRY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS01075
gene id: 697303:THEWI_RS01075
uniprot id: G2MRW8
names: Subcellular Location Annotation
messages: Cytoplasm

697303:THEWI RS01500
gene id: 697303:THEWI_RS01500
uniprot id: G2MSM2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

697303:THEWI RS11225
gene id: 697303:THEWI_RS11225
uniprot id: G2MWW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

697303:THEWI RS04370
gene id: 697303:THEWI_RS04370
uniprot id: G2MWE7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

697303:THEWI RS07905
gene id: 697303:THEWI_RS07905
uniprot id: G2MTA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PstS family.
messages: Cell membrane
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

697303:THEWI RS08645
gene id: 697303:THEWI_RS08645
uniprot id: G2MVJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

697303:THEWI RS06340
gene id: 697303:THEWI_RS06340
uniprot id: G2MVE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ScpB family.
messages: Cytoplasm
messages: Homodimer. Homodimerization may be required to stabilize the binding of ScpA to the Smc head domains. Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.
messages: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.

697303:THEWI RS09540
gene id: 697303:THEWI_RS09540
uniprot id: G2MRD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS08705
gene id: 697303:THEWI_RS08705
uniprot id: G2MVK8
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

697303:THEWI RS15230
gene id: 697303:THEWI_RS15230
uniprot id: G2MV64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

697303:THEWI RS06875
gene id: 697303:THEWI_RS06875
uniprot id: G2MXD4
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliO/MopB family.
messages: Cell membrane

697303:THEWI RS08800
gene id: 697303:THEWI_RS08800
uniprot id: G2MWP7
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

697303:THEWI RS00840
gene id: 697303:THEWI_RS00840
uniprot id: G2MW07
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

697303:THEWI RS04735
gene id: 697303:THEWI_RS04735
uniprot id: G2MXA1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

697303:THEWI RS09995
gene id: 697303:THEWI_RS09995
uniprot id: G2MTC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

697303:THEWI RS10860
gene id: 697303:THEWI_RS10860
uniprot id: G2MVN5
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

697303:THEWI RS06330
gene id: 697303:THEWI_RS06330
uniprot id: G2MVE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS03755
gene id: 697303:THEWI_RS03755
uniprot id: G2MV24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS03325
gene id: 697303:THEWI_RS03325
uniprot id: G2MSR4
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS04775
gene id: 697303:THEWI_RS04775
uniprot id: G2MXA8
names: Similarity
messages: Belongs to the peptidase C40 family.

697303:THEWI RS13210
gene id: 697303:THEWI_RS13210
uniprot id: G2MUE7
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

697303:THEWI RS06290
gene id: 697303:THEWI_RS06290
uniprot id: G2MVD2
names: Function
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.
messages: In the phosphorylated form it could act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma f from inhibition.

697303:THEWI RS03335
gene id: 697303:THEWI_RS03335
uniprot id: G2MSR6
names: Similarity
messages: Belongs to the GARS family.

697303:THEWI RS02980
gene id: 697303:THEWI_RS02980
uniprot id: G2MS29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

697303:THEWI RS11295
gene id: 697303:THEWI_RS11295
uniprot id: G2MWY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

697303:THEWI RS08390
gene id: 697303:THEWI_RS08390
uniprot id: G2MVF1
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

697303:THEWI RS04885
gene id: 697303:THEWI_RS04885
uniprot id: G2MR07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

697303:THEWI RS06180
gene id: 697303:THEWI_RS06180
uniprot id: G2MVA9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

697303:THEWI RS02765
gene id: 697303:THEWI_RS02765
uniprot id: G2MQX3
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

697303:THEWI RS08155
gene id: 697303:THEWI_RS08155
uniprot id: G2MTM7
names: Similarity
messages: Belongs to the peptidase M18 family.

697303:THEWI RS08930
gene id: 697303:THEWI_RS08930
uniprot id: G2MWS1
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

697303:THEWI RS13005
gene id: 697303:THEWI_RS13005
uniprot id: G2MUA8
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS02535
gene id: 697303:THEWI_RS02535
uniprot id: G2MQT2
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS07395
gene id: 697303:THEWI_RS07395
uniprot id: G2MRA8
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

697303:THEWI RS00775
gene id: 697303:THEWI_RS00775
uniprot id: G2MVZ5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS06210
gene id: 697303:THEWI_RS06210
uniprot id: G2MVB5
names: Similarity
messages: Belongs to the TlyA family.

697303:THEWI RS05460
gene id: 697303:THEWI_RS05460
uniprot id: G2MSD0
names: Similarity
messages: Belongs to the 6-phosphogluconate dehydrogenase family.

697303:THEWI RS06655
gene id: 697303:THEWI_RS06655
uniprot id: G2MWL2
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.

697303:THEWI RS05480
gene id: 697303:THEWI_RS05480
uniprot id: G2MSD4
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

697303:THEWI RS12950
gene id: 697303:THEWI_RS12950
uniprot id: G2MU96
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

697303:THEWI RS01520
gene id: 697303:THEWI_RS01520
uniprot id: G2MSM6
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS01815
gene id: 697303:THEWI_RS01815
uniprot id: G2MUV4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

697303:THEWI RS11475
gene id: 697303:THEWI_RS11475
uniprot id: G2MX17
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

697303:THEWI RS06980
gene id: 697303:THEWI_RS06980
uniprot id: G2MXF5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

697303:THEWI RS06105
gene id: 697303:THEWI_RS06105
uniprot id: G2MV94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

697303:THEWI RS12035
gene id: 697303:THEWI_RS12035
uniprot id: G2MRL8
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS04440
gene id: 697303:THEWI_RS04440
uniprot id: G2MX43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS04625
gene id: 697303:THEWI_RS04625
uniprot id: G2MX79
names: Similarity
messages: Belongs to the peptidase S49 family.

697303:THEWI RS04900
gene id: 697303:THEWI_RS04900
uniprot id: G2MR10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

697303:THEWI RS00050
gene id: 697303:THEWI_RS00050
uniprot id: G2MSG5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

697303:THEWI RS00305
gene id: 697303:THEWI_RS00305
uniprot id: G2MUP9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

697303:THEWI RS03255
gene id: 697303:THEWI_RS03255
uniprot id: G2MSQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

697303:THEWI RS11400
gene id: 697303:THEWI_RS11400
uniprot id: G2MX02
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

697303:THEWI RS11390
gene id: 697303:THEWI_RS11390
uniprot id: G2MX00
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

697303:THEWI RS06190
gene id: 697303:THEWI_RS06190
uniprot id: G2MVB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

697303:THEWI RS07915
gene id: 697303:THEWI_RS07915
uniprot id: G2MTA2
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

697303:THEWI RS00460
gene id: 697303:THEWI_RS00460
uniprot id: G2MUS5
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

697303:THEWI RS09520
gene id: 697303:THEWI_RS09520
uniprot id: G2MXR6
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

697303:THEWI RS11340
gene id: 697303:THEWI_RS11340
uniprot id: G2MWZ0
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

697303:THEWI RS10880
gene id: 697303:THEWI_RS10880
uniprot id: G2MVN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Probably a homodimer.

697303:THEWI RS00580
gene id: 697303:THEWI_RS00580
uniprot id: G2MVV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS08455
gene id: 697303:THEWI_RS08455
uniprot id: G2MVG2
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

697303:THEWI RS00100
gene id: 697303:THEWI_RS00100
uniprot id: G2MUL3
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

697303:THEWI RS07835
gene id: 697303:THEWI_RS07835
uniprot id: G2MT86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

697303:THEWI RS01360
gene id: 697303:THEWI_RS01360
uniprot id: G2MSJ4
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS11550
gene id: 697303:THEWI_RS11550
uniprot id: G2MX33
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

697303:THEWI RS05280
gene id: 697303:THEWI_RS05280
uniprot id: G2MS99
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.

697303:THEWI RS12445
gene id: 697303:THEWI_RS12445
uniprot id: G2MTZ8
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS05200
gene id: 697303:THEWI_RS05200
uniprot id: G2MS83
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

697303:THEWI RS09690
gene id: 697303:THEWI_RS09690
uniprot id: G2MRG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

697303:THEWI RS05960
gene id: 697303:THEWI_RS05960
uniprot id: G2MT35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

697303:THEWI RS03185
gene id: 697303:THEWI_RS03185
uniprot id: G2MS72
names: Similarity
messages: Belongs to the peptidase S8 family.

697303:THEWI RS13500
gene id: 697303:THEWI_RS13500
uniprot id: G2MUJ6
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer).
messages: Homodimer.
messages: In the C-terminal section; belongs to the MurCDEF family.

697303:THEWI RS05625
gene id: 697303:THEWI_RS05625
uniprot id: G2MSX0
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

697303:THEWI RS12830
gene id: 697303:THEWI_RS12830
uniprot id: G2MU72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Membrane

697303:THEWI RS01190
gene id: 697303:THEWI_RS01190
uniprot id: G2MRZ0
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS13575
gene id: 697303:THEWI_RS13575
uniprot id: G2MUL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

697303:THEWI RS00130
gene id: 697303:THEWI_RS00130
uniprot id: G2MUM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS12760
gene id: 697303:THEWI_RS12760
uniprot id: G2MU58
names: Similarity
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.

697303:THEWI RS08510
gene id: 697303:THEWI_RS08510
uniprot id: G2MVH3
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

697303:THEWI RS00020
gene id: 697303:THEWI_RS00020
uniprot id: G2MSF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

697303:THEWI RS05415
gene id: 697303:THEWI_RS05415
uniprot id: G2MSC1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

697303:THEWI RS06540
gene id: 697303:THEWI_RS06540
uniprot id: G2MWJ0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

697303:THEWI RS05430
gene id: 697303:THEWI_RS05430
uniprot id: G2MSC4
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SspI family.
messages: Expressed only in the forespore compartment of sporulating cells.
messages: Spore core

697303:THEWI RS02485
gene id: 697303:THEWI_RS02485
uniprot id: G2MQS3
names: Similarity
messages: Belongs to the HepT RNase toxin family.

697303:THEWI RS04435
gene id: 697303:THEWI_RS04435
uniprot id: G2MX42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS02740
gene id: 697303:THEWI_RS02740
uniprot id: G2MQW8
names: Function
names: Similarity
messages: Belongs to the RecD family. RecD-like subfamily.
messages: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.

697303:THEWI RS10530
gene id: 697303:THEWI_RS10530
uniprot id: G2MTU0
names: Subcellular Location Annotation
messages: Cytoplasm

697303:THEWI RS09225
gene id: 697303:THEWI_RS09225
uniprot id: G2MXL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

697303:THEWI RS11430
gene id: 697303:THEWI_RS11430
uniprot id: G2MX08
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

697303:THEWI RS10300
gene id: 697303:THEWI_RS10300
uniprot id: G2MTI2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS01260
gene id: 697303:THEWI_RS01260
uniprot id: G2MS04
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

697303:THEWI RS07995
gene id: 697303:THEWI_RS07995
uniprot id: G2MTJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

697303:THEWI RS00135
gene id: 697303:THEWI_RS00135
uniprot id: G2MUM1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS06985
gene id: 697303:THEWI_RS06985
uniprot id: G2MXF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

697303:THEWI RS01335
gene id: 697303:THEWI_RS01335
uniprot id: G2MSI9
names: Similarity
messages: Belongs to the threonine aldolase family.

697303:THEWI RS00805
gene id: 697303:THEWI_RS00805
uniprot id: G2MW01
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS08975
gene id: 697303:THEWI_RS08975
uniprot id: G2MWT0
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

697303:THEWI RS06215
gene id: 697303:THEWI_RS06215
uniprot id: G2MVB6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS02170
gene id: 697303:THEWI_RS02170
uniprot id: G2MW36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

697303:THEWI RS07025
gene id: 697303:THEWI_RS07025
uniprot id: G2MXG4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

697303:THEWI RS13245
gene id: 697303:THEWI_RS13245
uniprot id: G2MUF4
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

697303:THEWI RS00755
gene id: 697303:THEWI_RS00755
uniprot id: G2MVZ1
names: Similarity
messages: Belongs to the HypD family.

697303:THEWI RS01180
gene id: 697303:THEWI_RS01180
uniprot id: G2MRY8
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

697303:THEWI RS11250
gene id: 697303:THEWI_RS11250
uniprot id: G2MWX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

697303:THEWI RS13115
gene id: 697303:THEWI_RS13115
uniprot id: G2MUC7
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

697303:THEWI RS07960
gene id: 697303:THEWI_RS07960
uniprot id: G2MTB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sbp family.
messages: Cell membrane

697303:THEWI RS01995
gene id: 697303:THEWI_RS01995
uniprot id: G2MUY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

697303:THEWI RS13425
gene id: 697303:THEWI_RS13425
uniprot id: G2MUI2
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS09495
gene id: 697303:THEWI_RS09495
uniprot id: G2MXR2
names: Subcellular Location Annotation
messages: Cytoplasm

697303:THEWI RS02200
gene id: 697303:THEWI_RS02200
uniprot id: G2MW38
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

697303:THEWI RS12910
gene id: 697303:THEWI_RS12910
uniprot id: G2MU88
names: Similarity
messages: Belongs to the glycosyl hydrolase 26 family.

697303:THEWI RS06410
gene id: 697303:THEWI_RS06410
uniprot id: G2MWG4
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

697303:THEWI RS07520
gene id: 697303:THEWI_RS07520
uniprot id: G2MRC7
names: Similarity
messages: Belongs to the UPF0047 family.

697303:THEWI RS11205
gene id: 697303:THEWI_RS11205
uniprot id: G2MWW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

697303:THEWI RS04635
gene id: 697303:THEWI_RS04635
uniprot id: G2MX81
names: Similarity
messages: Belongs to the HepT RNase toxin family.

697303:THEWI RS03160
gene id: 697303:THEWI_RS03160
uniprot id: G2MS67
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

697303:THEWI RS06620
gene id: 697303:THEWI_RS06620
uniprot id: G2MWK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

697303:THEWI RS00055
gene id: 697303:THEWI_RS00055
uniprot id: G2MSG6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

697303:THEWI RS02785
gene id: 697303:THEWI_RS02785
uniprot id: G2MQX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

697303:THEWI RS08710
gene id: 697303:THEWI_RS08710
uniprot id: G2MVK9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

697303:THEWI RS07845
gene id: 697303:THEWI_RS07845
uniprot id: G2MT88
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

697303:THEWI RS07950
gene id: 697303:THEWI_RS07950
uniprot id: G2MTA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

697303:THEWI RS10180
gene id: 697303:THEWI_RS10180
uniprot id: G2MTF8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

697303:THEWI RS02525
gene id: 697303:THEWI_RS02525
uniprot id: G2MQT0
names: Similarity
messages: Belongs to the BMP lipoprotein family.

697303:THEWI RS08005
gene id: 697303:THEWI_RS08005
uniprot id: G2MTJ8
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

697303:THEWI RS12605
gene id: 697303:THEWI_RS12605
uniprot id: G2MU27
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS01480
gene id: 697303:THEWI_RS01480
uniprot id: G2MSL8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

697303:THEWI RS06735
gene id: 697303:THEWI_RS06735
uniprot id: G2MWM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

697303:THEWI RS00750
gene id: 697303:THEWI_RS00750
uniprot id: G2MVZ0
names: Similarity
messages: Belongs to the HupF/HypC family.

697303:THEWI RS11255
gene id: 697303:THEWI_RS11255
uniprot id: G2MWX3
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

697303:THEWI RS03330
gene id: 697303:THEWI_RS03330
uniprot id: G2MSR5
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

697303:THEWI RS10415
gene id: 697303:THEWI_RS10415
uniprot id: G2MTS2
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS06025
gene id: 697303:THEWI_RS06025
uniprot id: G2MV78
names: Similarity
messages: Belongs to the GSP E family.

697303:THEWI RS00080
gene id: 697303:THEWI_RS00080
uniprot id: G2MSH1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

697303:THEWI RS08825
gene id: 697303:THEWI_RS08825
uniprot id: G2MWQ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cleaves the N-terminal amino acid of tripeptides.
messages: Cytoplasm

697303:THEWI RS04280
gene id: 697303:THEWI_RS04280
uniprot id: G2MWD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Amj family.
messages: Cell membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.

697303:THEWI RS03770
gene id: 697303:THEWI_RS03770
uniprot id: G2MV27
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

697303:THEWI RS07535
gene id: 697303:THEWI_RS07535
uniprot id: G2MRD0
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

697303:THEWI RS00115
gene id: 697303:THEWI_RS00115
uniprot id: G2MUL6
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

697303:THEWI RS05270
gene id: 697303:THEWI_RS05270
uniprot id: G2MS97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

697303:THEWI RS04410
gene id: 697303:THEWI_RS04410
uniprot id: G2MWF4
names: Function
names: Similarity
messages: Belongs to the alpha/beta-type SASP family.
messages: SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.

697303:THEWI RS08480
gene id: 697303:THEWI_RS08480
uniprot id: G2MVG7
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

697303:THEWI RS13490
gene id: 697303:THEWI_RS13490
uniprot id: G2MUJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

697303:THEWI RS08445
gene id: 697303:THEWI_RS08445
uniprot id: G2MVG0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

697303:THEWI RS00825
gene id: 697303:THEWI_RS00825
uniprot id: G2MW04
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

697303:THEWI RS04220
gene id: 697303:THEWI_RS04220
uniprot id: G2MWB8
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

697303:THEWI RS09380
gene id: 697303:THEWI_RS09380
uniprot id: G2MXP0
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS13060
gene id: 697303:THEWI_RS13060
uniprot id: G2MUB7
names: Similarity
messages: Belongs to the peptidase S51 family.

697303:THEWI RS11435
gene id: 697303:THEWI_RS11435
uniprot id: G2MX09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Cell membrane
messages: H(+)-stimulated, divalent metal cation uptake system.

697303:THEWI RS03000
gene id: 697303:THEWI_RS03000
uniprot id: G2MS33
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

697303:THEWI RS00830
gene id: 697303:THEWI_RS00830
uniprot id: G2MW05
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

697303:THEWI RS09685
gene id: 697303:THEWI_RS09685
uniprot id: G2MRG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation.

697303:THEWI RS04870
gene id: 697303:THEWI_RS04870
uniprot id: G2MR04
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

697303:THEWI RS04695
gene id: 697303:THEWI_RS04695
uniprot id: G2MX93
names: Subcellular Location Annotation
messages: Membrane

697303:THEWI RS11270
gene id: 697303:THEWI_RS11270
uniprot id: G2MWX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.