694430:NATOC RS09930
gene id: 694430:NATOC_RS09930
uniprot id: L0JYP7
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS16595
gene id: 694430:NATOC_RS16595
uniprot id: L0K2G7
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

694430:NATOC RS00410
gene id: 694430:NATOC_RS00410
uniprot id: L0JVT2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

694430:NATOC RS17450
gene id: 694430:NATOC_RS17450
uniprot id: L0K5I7
names: Similarity
messages: Belongs to the TPP enzyme family.

694430:NATOC RS07875
gene id: 694430:NATOC_RS07875
uniprot id: L0JWQ2
names: Similarity
messages: Belongs to the CutA family.

694430:NATOC RS10410
gene id: 694430:NATOC_RS10410
uniprot id: L0K085
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

694430:NATOC RS17140
gene id: 694430:NATOC_RS17140
uniprot id: L0K1Z2
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

694430:NATOC RS12560
gene id: 694430:NATOC_RS12560
uniprot id: L0K1G4
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

694430:NATOC RS17215
gene id: 694430:NATOC_RS17215
uniprot id: L0K208
names: Similarity
messages: Belongs to the glycosyl hydrolase 68 family.

694430:NATOC RS00710
gene id: 694430:NATOC_RS00710
uniprot id: L0JVY6
names: Similarity
messages: Belongs to the RimK family. LysX subfamily.

694430:NATOC RS18730
gene id: 694430:NATOC_RS18730
uniprot id: L0K5F8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

694430:NATOC RS10065
gene id: 694430:NATOC_RS10065
uniprot id: L0K0M7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

694430:NATOC RS08100
gene id: 694430:NATOC_RS08100
uniprot id: L0JYW9
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

694430:NATOC RS19250
gene id: 694430:NATOC_RS19250
uniprot id: L0K5A0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

694430:NATOC RS06830
gene id: 694430:NATOC_RS06830
uniprot id: L0JZF0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

694430:NATOC RS15320
gene id: 694430:NATOC_RS15320
uniprot id: L0K325
names: Similarity
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.

694430:NATOC RS07005
gene id: 694430:NATOC_RS07005
uniprot id: L0JYW3
names: Similarity
messages: Belongs to the UPF0179 family.

694430:NATOC RS04315
gene id: 694430:NATOC_RS04315
uniprot id: L0JUP4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

694430:NATOC RS08865
gene id: 694430:NATOC_RS08865
uniprot id: L0JZW2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

694430:NATOC RS08015
gene id: 694430:NATOC_RS08015
uniprot id: L0K035
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

694430:NATOC RS19335
gene id: 694430:NATOC_RS19335
uniprot id: L0K3Z0
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

694430:NATOC RS15465
gene id: 694430:NATOC_RS15465
uniprot id: L0K102
names: Similarity
messages: Belongs to the peptidase M24B family.

694430:NATOC RS00460
gene id: 694430:NATOC_RS00460
uniprot id: L0JVT9
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

694430:NATOC RS01565
gene id: 694430:NATOC_RS01565
uniprot id: L0JTX0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

694430:NATOC RS09015
gene id: 694430:NATOC_RS09015
uniprot id: L0JXA8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

694430:NATOC RS08750
gene id: 694430:NATOC_RS08750
uniprot id: L0JX53
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

694430:NATOC RS00815
gene id: 694430:NATOC_RS00815
uniprot id: L0JUS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

694430:NATOC RS11755
gene id: 694430:NATOC_RS11755
uniprot id: L0K2A0
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

694430:NATOC RS06270
gene id: 694430:NATOC_RS06270
uniprot id: L0JWI6
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

694430:NATOC RS11285
gene id: 694430:NATOC_RS11285
uniprot id: L0K0P7
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

694430:NATOC RS08310
gene id: 694430:NATOC_RS08310
uniprot id: L0K091
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

694430:NATOC RS04795
gene id: 694430:NATOC_RS04795
uniprot id: L0JV15
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

694430:NATOC RS02645
gene id: 694430:NATOC_RS02645
uniprot id: L0JX32
names: Subcellular Location Annotation
messages: Cytoplasm

694430:NATOC RS18240
gene id: 694430:NATOC_RS18240
uniprot id: L0K5X8
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

694430:NATOC RS09730
gene id: 694430:NATOC_RS09730
uniprot id: L0JZW1
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

694430:NATOC RS02550
gene id: 694430:NATOC_RS02550
uniprot id: L0JWC4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS16370
gene id: 694430:NATOC_RS16370
uniprot id: L0K1G7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

694430:NATOC RS10435
gene id: 694430:NATOC_RS10435
uniprot id: L0K089
names: Similarity
messages: Belongs to the peptidase S8 family.

694430:NATOC RS05075
gene id: 694430:NATOC_RS05075
uniprot id: L0JV62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

694430:NATOC RS16435
gene id: 694430:NATOC_RS16435
uniprot id: L0K469
names: Similarity
messages: Belongs to the arginase family.

694430:NATOC RS13560
gene id: 694430:NATOC_RS13560
uniprot id: L0K0P9
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

694430:NATOC RS18465
gene id: 694430:NATOC_RS18465
uniprot id: L0K5B5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

694430:NATOC RS15955
gene id: 694430:NATOC_RS15955
uniprot id: L0K4N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

694430:NATOC RS19400
gene id: 694430:NATOC_RS19400
uniprot id: L0K5C7
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS19120
gene id: 694430:NATOC_RS19120
uniprot id: L0K315
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

694430:NATOC RS04610
gene id: 694430:NATOC_RS04610
uniprot id: L0JWZ3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS12195
gene id: 694430:NATOC_RS12195
uniprot id: L0K1A7
names: Caution
names: Function
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.
messages: Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a modified Entner-Doudoroff pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS12480
gene id: 694430:NATOC_RS12480
uniprot id: L0K1F1
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

694430:NATOC RS01025
gene id: 694430:NATOC_RS01025
uniprot id: L0JVE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

694430:NATOC RS02610
gene id: 694430:NATOC_RS02610
uniprot id: L0JUI0
names: Similarity
messages: Belongs to the NAD synthetase family.

694430:NATOC RS16530
gene id: 694430:NATOC_RS16530
uniprot id: L0K4Z3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

694430:NATOC RS02860
gene id: 694430:NATOC_RS02860
uniprot id: L0JVY0
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

694430:NATOC RS05870
gene id: 694430:NATOC_RS05870
uniprot id: L0JYW7
names: Similarity
messages: Belongs to the FGGY kinase family.

694430:NATOC RS13195
gene id: 694430:NATOC_RS13195
uniprot id: L0K323
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

694430:NATOC RS08835
gene id: 694430:NATOC_RS08835
uniprot id: L0K0I8
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

694430:NATOC RS05430
gene id: 694430:NATOC_RS05430
uniprot id: L0JXE6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

694430:NATOC RS21570
gene id: 694430:NATOC_RS21570
uniprot id: L0JXI5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

694430:NATOC RS16245
gene id: 694430:NATOC_RS16245
uniprot id: L0K1E2
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

694430:NATOC RS15110
gene id: 694430:NATOC_RS15110
uniprot id: L0K1P2
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS18385
gene id: 694430:NATOC_RS18385
uniprot id: L0K5Z8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

694430:NATOC RS16470
gene id: 694430:NATOC_RS16470
uniprot id: L0K2E6
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS18950
gene id: 694430:NATOC_RS18950
uniprot id: L0K6A2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base.
messages: Monomer and homodimer.

694430:NATOC RS02315
gene id: 694430:NATOC_RS02315
uniprot id: L0JTP3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

694430:NATOC RS07525
gene id: 694430:NATOC_RS07525
uniprot id: L0JWJ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

694430:NATOC RS00610
gene id: 694430:NATOC_RS00610
uniprot id: L0JVW8
names: Similarity
messages: Belongs to the UPF0201 family.

694430:NATOC RS19395
gene id: 694430:NATOC_RS19395
uniprot id: L0K5U8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS00865
gene id: 694430:NATOC_RS00865
uniprot id: L0JUT6
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS03590
gene id: 694430:NATOC_RS03590
uniprot id: L0JV02
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS03360
gene id: 694430:NATOC_RS03360
uniprot id: L0JUV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

694430:NATOC RS00535
gene id: 694430:NATOC_RS00535
uniprot id: L0JVV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

694430:NATOC RS00015
gene id: 694430:NATOC_RS00015
uniprot id: L0JSC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

694430:NATOC RS11810
gene id: 694430:NATOC_RS11810
uniprot id: L0K113
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS00005
gene id: 694430:NATOC_RS00005
uniprot id: L0JUD5
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

694430:NATOC RS12645
gene id: 694430:NATOC_RS12645
uniprot id: L0JZE2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

694430:NATOC RS14870
gene id: 694430:NATOC_RS14870
uniprot id: L0K429
names: Similarity
messages: Belongs to the RutC family.

694430:NATOC RS11340
gene id: 694430:NATOC_RS11340
uniprot id: L0JZG2
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

694430:NATOC RS13065
gene id: 694430:NATOC_RS13065
uniprot id: L0JZL2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

694430:NATOC RS02420
gene id: 694430:NATOC_RS02420
uniprot id: L0JWZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

694430:NATOC RS00910
gene id: 694430:NATOC_RS00910
uniprot id: L0JVC0
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

694430:NATOC RS05105
gene id: 694430:NATOC_RS05105
uniprot id: L0JYH6
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

694430:NATOC RS01055
gene id: 694430:NATOC_RS01055
uniprot id: L0JUX6
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS05350
gene id: 694430:NATOC_RS05350
uniprot id: L0JYM1
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

694430:NATOC RS13675
gene id: 694430:NATOC_RS13675
uniprot id: L0K3B1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Belongs to the inositol monophosphatase superfamily.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS07670
gene id: 694430:NATOC_RS07670
uniprot id: L0JYN3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

694430:NATOC RS07750
gene id: 694430:NATOC_RS07750
uniprot id: L0JXE4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

694430:NATOC RS02995
gene id: 694430:NATOC_RS02995
uniprot id: L0JU00
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

694430:NATOC RS05045
gene id: 694430:NATOC_RS05045
uniprot id: L0JVV9
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS11800
gene id: 694430:NATOC_RS11800
uniprot id: L0JYW6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Lysosome

694430:NATOC RS09420
gene id: 694430:NATOC_RS09420
uniprot id: L0K0W2
names: Function
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: May catalyze a purine salvage reaction, the substrate is unknown.

694430:NATOC RS13015
gene id: 694430:NATOC_RS13015
uniprot id: L0K2Y8
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS00270
gene id: 694430:NATOC_RS00270
uniprot id: L0JVQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

694430:NATOC RS01770
gene id: 694430:NATOC_RS01770
uniprot id: L0JVC6
names: Function
messages: Part of a potassium transport system.

694430:NATOC RS18195
gene id: 694430:NATOC_RS18195
uniprot id: L0K4N6
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

694430:NATOC RS12580
gene id: 694430:NATOC_RS12580
uniprot id: L0K211
names: Similarity
messages: Belongs to the RutC family.

694430:NATOC RS00040
gene id: 694430:NATOC_RS00040
uniprot id: L0JSD2
names: Similarity
messages: Belongs to the beta-eliminating lyase family.

694430:NATOC RS13395
gene id: 694430:NATOC_RS13395
uniprot id: L0K362
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

694430:NATOC RS00980
gene id: 694430:NATOC_RS00980
uniprot id: L0JTK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

694430:NATOC RS07305
gene id: 694430:NATOC_RS07305
uniprot id: L0JX58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

694430:NATOC RS00100
gene id: 694430:NATOC_RS00100
uniprot id: L0JUX4
names: Similarity
messages: Belongs to the peptidase M20A family.

694430:NATOC RS04005
gene id: 694430:NATOC_RS04005
uniprot id: L0JWJ8
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

694430:NATOC RS12175
gene id: 694430:NATOC_RS12175
uniprot id: L0JZZ5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

694430:NATOC RS18345
gene id: 694430:NATOC_RS18345
uniprot id: L0K4R3
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

694430:NATOC RS04600
gene id: 694430:NATOC_RS04600
uniprot id: L0JY97
names: Similarity
messages: Belongs to the cytochrome P450 family.

694430:NATOC RS12945
gene id: 694430:NATOC_RS12945
uniprot id: L0K2X2
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

694430:NATOC RS06095
gene id: 694430:NATOC_RS06095
uniprot id: L0JXS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

694430:NATOC RS16790
gene id: 694430:NATOC_RS16790
uniprot id: L0K1Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

694430:NATOC RS13230
gene id: 694430:NATOC_RS13230
uniprot id: L0K1T6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

694430:NATOC RS06520
gene id: 694430:NATOC_RS06520
uniprot id: L0JY02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ModE family.
messages: Membrane

694430:NATOC RS02930
gene id: 694430:NATOC_RS02930
uniprot id: L0JWI9
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

694430:NATOC RS20270
gene id: 694430:NATOC_RS20270
uniprot id: L0K730
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS17895
gene id: 694430:NATOC_RS17895
uniprot id: L0K4I5
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

694430:NATOC RS00905
gene id: 694430:NATOC_RS00905
uniprot id: L0JW21
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

694430:NATOC RS13720
gene id: 694430:NATOC_RS13720
uniprot id: L0JZX5
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.

694430:NATOC RS06895
gene id: 694430:NATOC_RS06895
uniprot id: L0JW53
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

694430:NATOC RS10050
gene id: 694430:NATOC_RS10050
uniprot id: L0JYR9
names: Similarity
messages: Belongs to the peptidase S9C family.

694430:NATOC RS01510
gene id: 694430:NATOC_RS01510
uniprot id: L0JV74
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

694430:NATOC RS16295
gene id: 694430:NATOC_RS16295
uniprot id: L0K1F2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

694430:NATOC RS06615
gene id: 694430:NATOC_RS06615
uniprot id: L0JZA2
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS03355
gene id: 694430:NATOC_RS03355
uniprot id: L0JW66
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

694430:NATOC RS12270
gene id: 694430:NATOC_RS12270
uniprot id: L0K1B6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

694430:NATOC RS13880
gene id: 694430:NATOC_RS13880
uniprot id: L0K0W9
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS03110
gene id: 694430:NATOC_RS03110
uniprot id: L0JWM4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

694430:NATOC RS20615
gene id: 694430:NATOC_RS20615
uniprot id: L0K7A6
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

694430:NATOC RS10060
gene id: 694430:NATOC_RS10060
uniprot id: L0K196
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS14535
gene id: 694430:NATOC_RS14535
uniprot id: L0K0I3
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

694430:NATOC RS04425
gene id: 694430:NATOC_RS04425
uniprot id: L0JY41
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS19130
gene id: 694430:NATOC_RS19130
uniprot id: L0K575
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

694430:NATOC RS16510
gene id: 694430:NATOC_RS16510
uniprot id: L0K486
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS13740
gene id: 694430:NATOC_RS13740
uniprot id: L0K0T4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

694430:NATOC RS17260
gene id: 694430:NATOC_RS17260
uniprot id: L0K461
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

694430:NATOC RS01275
gene id: 694430:NATOC_RS01275
uniprot id: L0JVJ1
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

694430:NATOC RS11510
gene id: 694430:NATOC_RS11510
uniprot id: L0K1D7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

694430:NATOC RS08645
gene id: 694430:NATOC_RS08645
uniprot id: L0JX31
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

694430:NATOC RS04855
gene id: 694430:NATOC_RS04855
uniprot id: L0JXN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

694430:NATOC RS19275
gene id: 694430:NATOC_RS19275
uniprot id: L0K5A6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

694430:NATOC RS05755
gene id: 694430:NATOC_RS05755
uniprot id: L0JVH6
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

694430:NATOC RS20215
gene id: 694430:NATOC_RS20215
uniprot id: L0K718
names: Similarity
messages: Belongs to the asparaginase 1 family.

694430:NATOC RS06340
gene id: 694430:NATOC_RS06340
uniprot id: L0JYE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

694430:NATOC RS06245
gene id: 694430:NATOC_RS06245
uniprot id: L0JWI2
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS13360
gene id: 694430:NATOC_RS13360
uniprot id: L0K0K9
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

694430:NATOC RS10605
gene id: 694430:NATOC_RS10605
uniprot id: L0K0B8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS20400
gene id: 694430:NATOC_RS20400
uniprot id: L0K6H1
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

694430:NATOC RS05320
gene id: 694430:NATOC_RS05320
uniprot id: L0JVA0
names: Similarity
messages: Belongs to the TPP enzyme family.

694430:NATOC RS16110
gene id: 694430:NATOC_RS16110
uniprot id: L0K410
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

694430:NATOC RS12930
gene id: 694430:NATOC_RS12930
uniprot id: L0K275
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

694430:NATOC RS19345
gene id: 694430:NATOC_RS19345
uniprot id: L0K6I5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

694430:NATOC RS17920
gene id: 694430:NATOC_RS17920
uniprot id: L0K4I8
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

694430:NATOC RS07655
gene id: 694430:NATOC_RS07655
uniprot id: L0JWL2
names: Similarity
messages: Belongs to the Dps family.

694430:NATOC RS20540
gene id: 694430:NATOC_RS20540
uniprot id: L0K3X4
names: Similarity
messages: Belongs to the TPP enzyme family.

694430:NATOC RS06675
gene id: 694430:NATOC_RS06675
uniprot id: L0JY32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

694430:NATOC RS17675
gene id: 694430:NATOC_RS17675
uniprot id: L0K4E2
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS16120
gene id: 694430:NATOC_RS16120
uniprot id: L0K273
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

694430:NATOC RS19850
gene id: 694430:NATOC_RS19850
uniprot id: L0K5Q7
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A 'suicide' enzyme that participates in biotin synthesis. Catalyzes the formation of (S)-8-amino-7-oxononanoate (DAN-carbamic acid) from (7R,8S)-8-amino-7-(carboxyamino)nonanoate (DAN), a function equivalent to the cannonical BioA reaction and the first half-reaction of BioD. The cellular requirement for biotin is thought be low enough that this single turnover enzyme supplies a sufficient amount of the cofactor. Overall it catalyzes three reactions: formation of a covalent linkage with 8-amino-7-oxononanoate to yield a BioU-DAN conjugate at the epsilon-amino group of Lys124 of BioU using NAD(P)H, carboxylation of the conjugate to form BioU-DAN-carbamic acid, and release of DAN-carbamic acid using NAD(P)+.
messages: Belongs to the BioU family.
messages: In cannonical biotin synthesis a pimeloyl-conjugate is transformed into biotin by the subsequent action of BioF, BioA, BioD and BioB. This enzyme replaces BioA and performs the first half-reaction of BioD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

694430:NATOC RS16240
gene id: 694430:NATOC_RS16240
uniprot id: L0K3J6
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

694430:NATOC RS03115
gene id: 694430:NATOC_RS03115
uniprot id: L0JW22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

694430:NATOC RS11740
gene id: 694430:NATOC_RS11740
uniprot id: L0K0Z7
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

694430:NATOC RS03855
gene id: 694430:NATOC_RS03855
uniprot id: L0JUF2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

694430:NATOC RS03190
gene id: 694430:NATOC_RS03190
uniprot id: L0JUT1
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

694430:NATOC RS16545
gene id: 694430:NATOC_RS16545
uniprot id: L0K2F9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

694430:NATOC RS13075
gene id: 694430:NATOC_RS13075
uniprot id: L0K2A4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS15240
gene id: 694430:NATOC_RS15240
uniprot id: L0K498
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.

694430:NATOC RS18140
gene id: 694430:NATOC_RS18140
uniprot id: L0K3B6
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

694430:NATOC RS13085
gene id: 694430:NATOC_RS13085
uniprot id: L0K0F5
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

694430:NATOC RS10565
gene id: 694430:NATOC_RS10565
uniprot id: L0JZ03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

694430:NATOC RS16570
gene id: 694430:NATOC_RS16570
uniprot id: L0K2G1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

694430:NATOC RS19010
gene id: 694430:NATOC_RS19010
uniprot id: L0K545
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 zinc ion.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

694430:NATOC RS09295
gene id: 694430:NATOC_RS09295
uniprot id: L0JY95
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS12010
gene id: 694430:NATOC_RS12010
uniprot id: L0K1R5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

694430:NATOC RS20130
gene id: 694430:NATOC_RS20130
uniprot id: L0K4G7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS05915
gene id: 694430:NATOC_RS05915
uniprot id: L0JWB7
names: Similarity
messages: Belongs to the PrpD family.

694430:NATOC RS06765
gene id: 694430:NATOC_RS06765
uniprot id: L0JW24
names: Similarity
messages: Belongs to the PEPCase type 1 family.

694430:NATOC RS07345
gene id: 694430:NATOC_RS07345
uniprot id: L0JYH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

694430:NATOC RS08520
gene id: 694430:NATOC_RS08520
uniprot id: L0JZ42
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

694430:NATOC RS15880
gene id: 694430:NATOC_RS15880
uniprot id: L0K3X2
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS18960
gene id: 694430:NATOC_RS18960
uniprot id: L0K535
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS02435
gene id: 694430:NATOC_RS02435
uniprot id: L0JUF1
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

694430:NATOC RS11335
gene id: 694430:NATOC_RS11335
uniprot id: L0K0R0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

694430:NATOC RS08530
gene id: 694430:NATOC_RS08530
uniprot id: L0JX06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

694430:NATOC RS13345
gene id: 694430:NATOC_RS13345
uniprot id: L0K355
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

694430:NATOC RS13820
gene id: 694430:NATOC_RS13820
uniprot id: L0K3E1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

694430:NATOC RS03095
gene id: 694430:NATOC_RS03095
uniprot id: L0JUR3
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

694430:NATOC RS04895
gene id: 694430:NATOC_RS04895
uniprot id: L0JV33
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

694430:NATOC RS01825
gene id: 694430:NATOC_RS01825
uniprot id: L0JU19
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

694430:NATOC RS10175
gene id: 694430:NATOC_RS10175
uniprot id: L0K1B2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

694430:NATOC RS08270
gene id: 694430:NATOC_RS08270
uniprot id: L0JZ01
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS07110
gene id: 694430:NATOC_RS07110
uniprot id: L0JYZ6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS15375
gene id: 694430:NATOC_RS15375
uniprot id: L0K3N4
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

694430:NATOC RS18045
gene id: 694430:NATOC_RS18045
uniprot id: L0K2G0
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

694430:NATOC RS07680
gene id: 694430:NATOC_RS07680
uniprot id: L0JWL7
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

694430:NATOC RS08590
gene id: 694430:NATOC_RS08590
uniprot id: L0JZ58
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

694430:NATOC RS09915
gene id: 694430:NATOC_RS09915
uniprot id: L0K173
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS01910
gene id: 694430:NATOC_RS01910
uniprot id: L0JWN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

694430:NATOC RS10440
gene id: 694430:NATOC_RS10440
uniprot id: L0JYY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

694430:NATOC RS05575
gene id: 694430:NATOC_RS05575
uniprot id: L0JY13
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS14970
gene id: 694430:NATOC_RS14970
uniprot id: L0K445
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS08450
gene id: 694430:NATOC_RS08450
uniprot id: L0JXS0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS04885
gene id: 694430:NATOC_RS04885
uniprot id: L0JX47
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS13885
gene id: 694430:NATOC_RS13885
uniprot id: L0K016
names: Similarity
messages: Belongs to the peptidase S8 family.

694430:NATOC RS15875
gene id: 694430:NATOC_RS15875
uniprot id: L0K4L9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

694430:NATOC RS03045
gene id: 694430:NATOC_RS03045
uniprot id: L0JUQ3
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

694430:NATOC RS14655
gene id: 694430:NATOC_RS14655
uniprot id: L0K2P9
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS15790
gene id: 694430:NATOC_RS15790
uniprot id: L0K207
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS06645
gene id: 694430:NATOC_RS06645
uniprot id: L0JYL5
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

694430:NATOC RS03345
gene id: 694430:NATOC_RS03345
uniprot id: L0JXG3
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS09255
gene id: 694430:NATOC_RS09255
uniprot id: L0K0S5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS20660
gene id: 694430:NATOC_RS20660
uniprot id: L0K3Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

694430:NATOC RS08630
gene id: 694430:NATOC_RS08630
uniprot id: L0JZS1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

694430:NATOC RS09600
gene id: 694430:NATOC_RS09600
uniprot id: L0K0E6
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

694430:NATOC RS15265
gene id: 694430:NATOC_RS15265
uniprot id: L0K3L6
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS12870
gene id: 694430:NATOC_RS12870
uniprot id: L0JZH9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS14715
gene id: 694430:NATOC_RS14715
uniprot id: L0K1H2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

694430:NATOC RS03745
gene id: 694430:NATOC_RS03745
uniprot id: L0JWE3
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.

694430:NATOC RS18805
gene id: 694430:NATOC_RS18805
uniprot id: L0K5H2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

694430:NATOC RS05855
gene id: 694430:NATOC_RS05855
uniprot id: L0JY66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Membrane

694430:NATOC RS18120
gene id: 694430:NATOC_RS18120
uniprot id: L0K2H0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS15620
gene id: 694430:NATOC_RS15620
uniprot id: L0K3T2
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

694430:NATOC RS02840
gene id: 694430:NATOC_RS02840
uniprot id: L0JTX3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

694430:NATOC RS18885
gene id: 694430:NATOC_RS18885
uniprot id: L0K519
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

694430:NATOC RS20125
gene id: 694430:NATOC_RS20125
uniprot id: L0K5V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

694430:NATOC RS00975
gene id: 694430:NATOC_RS00975
uniprot id: L0JUV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

694430:NATOC RS13040
gene id: 694430:NATOC_RS13040
uniprot id: L0JZK7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

694430:NATOC RS07065
gene id: 694430:NATOC_RS07065
uniprot id: L0JYD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

694430:NATOC RS12000
gene id: 694430:NATOC_RS12000
uniprot id: L0JZ22
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

694430:NATOC RS05545
gene id: 694430:NATOC_RS05545
uniprot id: L0JYQ7
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

694430:NATOC RS07325
gene id: 694430:NATOC_RS07325
uniprot id: L0JX63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

694430:NATOC RS05055
gene id: 694430:NATOC_RS05055
uniprot id: L0JYG6
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS15680
gene id: 694430:NATOC_RS15680
uniprot id: L0K1Y9
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS16880
gene id: 694430:NATOC_RS16880
uniprot id: L0K4G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

694430:NATOC RS03050
gene id: 694430:NATOC_RS03050
uniprot id: L0JU08
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

694430:NATOC RS08290
gene id: 694430:NATOC_RS08290
uniprot id: L0JZK9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS01765
gene id: 694430:NATOC_RS01765
uniprot id: L0JVU7
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

694430:NATOC RS07945
gene id: 694430:NATOC_RS07945
uniprot id: L0JWR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

694430:NATOC RS10525
gene id: 694430:NATOC_RS10525
uniprot id: L0JY59
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS16615
gene id: 694430:NATOC_RS16615
uniprot id: L0K3S4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

694430:NATOC RS19320
gene id: 694430:NATOC_RS19320
uniprot id: L0K6H8
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

694430:NATOC RS07970
gene id: 694430:NATOC_RS07970
uniprot id: L0K025
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

694430:NATOC RS15335
gene id: 694430:NATOC_RS15335
uniprot id: L0K4B9
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

694430:NATOC RS15355
gene id: 694430:NATOC_RS15355
uniprot id: L0K330
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS01370
gene id: 694430:NATOC_RS01370
uniprot id: L0JV40
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

694430:NATOC RS20115
gene id: 694430:NATOC_RS20115
uniprot id: L0K701
names: Subcellular Location Annotation
messages: Cytoplasm

694430:NATOC RS01865
gene id: 694430:NATOC_RS01865
uniprot id: L0JVX2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

694430:NATOC RS18220
gene id: 694430:NATOC_RS18220
uniprot id: L0K577
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS09855
gene id: 694430:NATOC_RS09855
uniprot id: L0JYN5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS14615
gene id: 694430:NATOC_RS14615
uniprot id: L0K1E8
names: Similarity
messages: Belongs to the peptidase S8 family.

694430:NATOC RS08720
gene id: 694430:NATOC_RS08720
uniprot id: L0JZ85
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

694430:NATOC RS16255
gene id: 694430:NATOC_RS16255
uniprot id: L0K434
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

694430:NATOC RS02445
gene id: 694430:NATOC_RS02445
uniprot id: L0JWZ9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

694430:NATOC RS08740
gene id: 694430:NATOC_RS08740
uniprot id: L0JZT9
names: Subcellular Location Annotation
messages: Nucleus

694430:NATOC RS03525
gene id: 694430:NATOC_RS03525
uniprot id: L0JW99
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

694430:NATOC RS06030
gene id: 694430:NATOC_RS06030
uniprot id: L0JXR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

694430:NATOC RS15315
gene id: 694430:NATOC_RS15315
uniprot id: L0K3M4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

694430:NATOC RS10640
gene id: 694430:NATOC_RS10640
uniprot id: L0JY78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

694430:NATOC RS00500
gene id: 694430:NATOC_RS00500
uniprot id: L0JTC3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

694430:NATOC RS14195
gene id: 694430:NATOC_RS14195
uniprot id: L0K2D2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS12795
gene id: 694430:NATOC_RS12795
uniprot id: L0JZG6
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

694430:NATOC RS06705
gene id: 694430:NATOC_RS06705
uniprot id: L0JWR8
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

694430:NATOC RS09025
gene id: 694430:NATOC_RS09025
uniprot id: L0JZZ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

694430:NATOC RS08250
gene id: 694430:NATOC_RS08250
uniprot id: L0JYZ7
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

694430:NATOC RS04035
gene id: 694430:NATOC_RS04035
uniprot id: L0JV88
names: Similarity
messages: Belongs to the DtxR/MntR family.

694430:NATOC RS16280
gene id: 694430:NATOC_RS16280
uniprot id: L0K440
names: Similarity
messages: Belongs to the phosphohexose mutase family.

694430:NATOC RS18230
gene id: 694430:NATOC_RS18230
uniprot id: L0K3D1
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS06625
gene id: 694430:NATOC_RS06625
uniprot id: L0JY21
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

694430:NATOC RS04205
gene id: 694430:NATOC_RS04205
uniprot id: L0JXZ0
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

694430:NATOC RS12255
gene id: 694430:NATOC_RS12255
uniprot id: L0JZ75
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

694430:NATOC RS19805
gene id: 694430:NATOC_RS19805
uniprot id: L0K4B1
names: Similarity
messages: Belongs to the gas vesicle GvpA family.

694430:NATOC RS11225
gene id: 694430:NATOC_RS11225
uniprot id: L0K1Y0
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

694430:NATOC RS06200
gene id: 694430:NATOC_RS06200
uniprot id: L0JYC7
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

694430:NATOC RS00205
gene id: 694430:NATOC_RS00205
uniprot id: L0JUH1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

694430:NATOC RS10710
gene id: 694430:NATOC_RS10710
uniprot id: L0K0D5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS04605
gene id: 694430:NATOC_RS04605
uniprot id: L0JXI7
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS19025
gene id: 694430:NATOC_RS19025
uniprot id: L0K6B7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

694430:NATOC RS16560
gene id: 694430:NATOC_RS16560
uniprot id: L0K497
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

694430:NATOC RS00695
gene id: 694430:NATOC_RS00695
uniprot id: L0JUQ4
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS00425
gene id: 694430:NATOC_RS00425
uniprot id: L0JTA6
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

694430:NATOC RS01750
gene id: 694430:NATOC_RS01750
uniprot id: L0JU06
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS15785
gene id: 694430:NATOC_RS15785
uniprot id: L0K3A3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS18835
gene id: 694430:NATOC_RS18835
uniprot id: L0K507
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

694430:NATOC RS20715
gene id: 694430:NATOC_RS20715
uniprot id: L0K4S6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

694430:NATOC RS18010
gene id: 694430:NATOC_RS18010
uniprot id: L0K2F6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

694430:NATOC RS14755
gene id: 694430:NATOC_RS14755
uniprot id: L0K3B8
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS00565
gene id: 694430:NATOC_RS00565
uniprot id: L0JV59
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

694430:NATOC RS13830
gene id: 694430:NATOC_RS13830
uniprot id: L0K0V7
names: Subcellular Location Annotation
messages: Cell membrane

694430:NATOC RS08880
gene id: 694430:NATOC_RS08880
uniprot id: L0JX79
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

694430:NATOC RS18455
gene id: 694430:NATOC_RS18455
uniprot id: L0K2N1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS09920
gene id: 694430:NATOC_RS09920
uniprot id: L0K0J9
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS14995
gene id: 694430:NATOC_RS14995
uniprot id: L0K449
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

694430:NATOC RS01010
gene id: 694430:NATOC_RS01010
uniprot id: L0JUW5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

694430:NATOC RS11885
gene id: 694430:NATOC_RS11885
uniprot id: L0K130
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the oxidation of methyl-H(4)MPT to methylene-H(4)MPT.
messages: Cytoplasm

694430:NATOC RS17780
gene id: 694430:NATOC_RS17780
uniprot id: L0K2B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

694430:NATOC RS14020
gene id: 694430:NATOC_RS14020
uniprot id: L0K3I6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

694430:NATOC RS08860
gene id: 694430:NATOC_RS08860
uniprot id: L0K0J3
names: Subunit
messages: Homotetramer.

694430:NATOC RS11555
gene id: 694430:NATOC_RS11555
uniprot id: L0K253
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS09850
gene id: 694430:NATOC_RS09850
uniprot id: L0JZY2
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS01715
gene id: 694430:NATOC_RS01715
uniprot id: L0JVT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

694430:NATOC RS01945
gene id: 694430:NATOC_RS01945
uniprot id: L0JVH4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

694430:NATOC RS00560
gene id: 694430:NATOC_RS00560
uniprot id: L0JVV7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.

694430:NATOC RS06470
gene id: 694430:NATOC_RS06470
uniprot id: L0JXZ1
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

694430:NATOC RS19370
gene id: 694430:NATOC_RS19370
uniprot id: L0K5U2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS00855
gene id: 694430:NATOC_RS00855
uniprot id: L0JW12
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

694430:NATOC RS01080
gene id: 694430:NATOC_RS01080
uniprot id: L0JVF6
names: Similarity
messages: Belongs to the AOR/FOR family.

694430:NATOC RS09820
gene id: 694430:NATOC_RS09820
uniprot id: L0K0H9
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS13205
gene id: 694430:NATOC_RS13205
uniprot id: L0K1T1
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

694430:NATOC RS02905
gene id: 694430:NATOC_RS02905
uniprot id: L0JWI5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Purine nucleoside phosphorylase involved in purine salvage.

694430:NATOC RS04850
gene id: 694430:NATOC_RS04850
uniprot id: L0JYD6
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS07120
gene id: 694430:NATOC_RS07120
uniprot id: L0JX29
names: Similarity
messages: Belongs to the UPF0212 family.

694430:NATOC RS16555
gene id: 694430:NATOC_RS16555
uniprot id: L0K4Z9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

694430:NATOC RS11280
gene id: 694430:NATOC_RS11280
uniprot id: L0K194
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

694430:NATOC RS03605
gene id: 694430:NATOC_RS03605
uniprot id: L0JWV9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS00070
gene id: 694430:NATOC_RS00070
uniprot id: L0JVL7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

694430:NATOC RS00735
gene id: 694430:NATOC_RS00735
uniprot id: L0JVZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

694430:NATOC RS18750
gene id: 694430:NATOC_RS18750
uniprot id: L0K666
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS11835
gene id: 694430:NATOC_RS11835
uniprot id: L0K118
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

694430:NATOC RS20770
gene id: 694430:NATOC_RS20770
uniprot id: L0K668
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

694430:NATOC RS18705
gene id: 694430:NATOC_RS18705
uniprot id: L0K5F2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

694430:NATOC RS12975
gene id: 694430:NATOC_RS12975
uniprot id: L0K286
names: Similarity
messages: Belongs to the UPF0173 family.

694430:NATOC RS10115
gene id: 694430:NATOC_RS10115
uniprot id: L0K1A5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

694430:NATOC RS08170
gene id: 694430:NATOC_RS08170
uniprot id: L0JZI9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

694430:NATOC RS19980
gene id: 694430:NATOC_RS19980
uniprot id: L0K4E3
names: Similarity
messages: Belongs to the UPF0047 family.

694430:NATOC RS02195
gene id: 694430:NATOC_RS02195
uniprot id: L0JW68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

694430:NATOC RS02655
gene id: 694430:NATOC_RS02655
uniprot id: L0JVU4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS14545
gene id: 694430:NATOC_RS14545
uniprot id: L0K3X7
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS19135
gene id: 694430:NATOC_RS19135
uniprot id: L0K3V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

694430:NATOC RS03965
gene id: 694430:NATOC_RS03965
uniprot id: L0JUH4
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

694430:NATOC RS02320
gene id: 694430:NATOC_RS02320
uniprot id: L0JWX9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS04860
gene id: 694430:NATOC_RS04860
uniprot id: L0JX42
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS02415
gene id: 694430:NATOC_RS02415
uniprot id: L0JTQ9
names: Similarity
messages: Belongs to the UPF0440 family.

694430:NATOC RS19055
gene id: 694430:NATOC_RS19055
uniprot id: L0K5L5
names: Similarity
messages: Belongs to the truncated hemoglobin family. Group I subfamily.

694430:NATOC RS14100
gene id: 694430:NATOC_RS14100
uniprot id: L0K116
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

694430:NATOC RS05255
gene id: 694430:NATOC_RS05255
uniprot id: L0JXV1
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

694430:NATOC RS10615
gene id: 694430:NATOC_RS10615
uniprot id: L0JY74
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS17335
gene id: 694430:NATOC_RS17335
uniprot id: L0K229
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

694430:NATOC RS05180
gene id: 694430:NATOC_RS05180
uniprot id: L0JYJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

694430:NATOC RS09885
gene id: 694430:NATOC_RS09885
uniprot id: L0JXV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

694430:NATOC RS14435
gene id: 694430:NATOC_RS14435
uniprot id: L0K0D6
names: Similarity
messages: Belongs to the peptidase S8 family.

694430:NATOC RS11875
gene id: 694430:NATOC_RS11875
uniprot id: L0K2C8
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

694430:NATOC RS10990
gene id: 694430:NATOC_RS10990
uniprot id: L0JYE3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NAD to NADH.
messages: Homotetramer.

694430:NATOC RS11615
gene id: 694430:NATOC_RS11615
uniprot id: L0K0X0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

694430:NATOC RS00510
gene id: 694430:NATOC_RS00510
uniprot id: L0JVU8
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

694430:NATOC RS00990
gene id: 694430:NATOC_RS00990
uniprot id: L0JW37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

694430:NATOC RS13005
gene id: 694430:NATOC_RS13005
uniprot id: L0K0D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

694430:NATOC RS07220
gene id: 694430:NATOC_RS07220
uniprot id: L0JYF8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methylaspartate mutase GlmE subunit family.
messages: Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).
messages: Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS02765
gene id: 694430:NATOC_RS02765
uniprot id: L0JUK5
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

694430:NATOC RS17745
gene id: 694430:NATOC_RS17745
uniprot id: L0K4F7
names: Similarity
messages: Belongs to the peptidase C56 family.

694430:NATOC RS15810
gene id: 694430:NATOC_RS15810
uniprot id: L0K3V9
names: Similarity
messages: Belongs to the GcvT family.

694430:NATOC RS17805
gene id: 694430:NATOC_RS17805
uniprot id: L0K5P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

694430:NATOC RS03705
gene id: 694430:NATOC_RS03705
uniprot id: L0JWD4
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

694430:NATOC RS04930
gene id: 694430:NATOC_RS04930
uniprot id: L0JXP1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

694430:NATOC RS02185
gene id: 694430:NATOC_RS02185
uniprot id: L0JTM5
names: Similarity
messages: Belongs to the thymidylate kinase family.

694430:NATOC RS00900
gene id: 694430:NATOC_RS00900
uniprot id: L0JSS5
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

694430:NATOC RS17775
gene id: 694430:NATOC_RS17775
uniprot id: L0K356
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

694430:NATOC RS13060
gene id: 694430:NATOC_RS13060
uniprot id: L0K0F1
names: Function
names: Similarity
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

694430:NATOC RS09760
gene id: 694430:NATOC_RS09760
uniprot id: L0JYL2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS09870
gene id: 694430:NATOC_RS09870
uniprot id: L0K0J0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

694430:NATOC RS07975
gene id: 694430:NATOC_RS07975
uniprot id: L0JZE8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

694430:NATOC RS17230
gene id: 694430:NATOC_RS17230
uniprot id: L0K457
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Membrane

694430:NATOC RS04745
gene id: 694430:NATOC_RS04745
uniprot id: L0JV08
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

694430:NATOC RS05415
gene id: 694430:NATOC_RS05415
uniprot id: L0JVB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

694430:NATOC RS18765
gene id: 694430:NATOC_RS18765
uniprot id: L0K3M5
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS03875
gene id: 694430:NATOC_RS03875
uniprot id: L0JV60
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

694430:NATOC RS09900
gene id: 694430:NATOC_RS09900
uniprot id: L0JZZ0
names: Subcellular Location Annotation
messages: Cytoplasm

694430:NATOC RS09125
gene id: 694430:NATOC_RS09125
uniprot id: L0JY60
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

694430:NATOC RS17625
gene id: 694430:NATOC_RS17625
uniprot id: L0K4W6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

694430:NATOC RS12640
gene id: 694430:NATOC_RS12640
uniprot id: U3GK75
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS19790
gene id: 694430:NATOC_RS19790
uniprot id: L0K6V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gas vesicle GvpF/GvpL family.
messages: Gas vesicle
messages: Vesicle

694430:NATOC RS00335
gene id: 694430:NATOC_RS00335
uniprot id: L0JSH6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

694430:NATOC RS07070
gene id: 694430:NATOC_RS07070
uniprot id: L0JX18
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

694430:NATOC RS10265
gene id: 694430:NATOC_RS10265
uniprot id: L0K1D1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cell membrane
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Membrane
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

694430:NATOC RS16575
gene id: 694430:NATOC_RS16575
uniprot id: L0K1L0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

694430:NATOC RS12390
gene id: 694430:NATOC_RS12390
uniprot id: L0K1Y2
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

694430:NATOC RS08615
gene id: 694430:NATOC_RS08615
uniprot id: L0JXW1
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

694430:NATOC RS13940
gene id: 694430:NATOC_RS13940
uniprot id: L0K029
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS00845
gene id: 694430:NATOC_RS00845
uniprot id: L0JTH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.
messages: Cell membrane
messages: Forms a complex with DabB.
messages: Part of an energy-coupled inorganic carbon pump.

694430:NATOC RS05875
gene id: 694430:NATOC_RS05875
uniprot id: L0JY71
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

694430:NATOC RS16830
gene id: 694430:NATOC_RS16830
uniprot id: L0K3W6
names: Similarity
messages: Belongs to the LarC family.

694430:NATOC RS08555
gene id: 694430:NATOC_RS08555
uniprot id: L0K0D3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

694430:NATOC RS11735
gene id: 694430:NATOC_RS11735
uniprot id: L0K1I9
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

694430:NATOC RS15690
gene id: 694430:NATOC_RS15690
uniprot id: L0K4I7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS08625
gene id: 694430:NATOC_RS08625
uniprot id: L0K0E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

694430:NATOC RS02410
gene id: 694430:NATOC_RS02410
uniprot id: L0JUE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

694430:NATOC RS18065
gene id: 694430:NATOC_RS18065
uniprot id: L0K2G3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS16465
gene id: 694430:NATOC_RS16465
uniprot id: L0K3P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

694430:NATOC RS07475
gene id: 694430:NATOC_RS07475
uniprot id: L0JWI4
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

694430:NATOC RS08315
gene id: 694430:NATOC_RS08315
uniprot id: L0JZL5
names: Similarity
messages: Belongs to the MscS (TC 1.A.23) family.

694430:NATOC RS07420
gene id: 694430:NATOC_RS07420
uniprot id: L0JX83
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

694430:NATOC RS02060
gene id: 694430:NATOC_RS02060
uniprot id: L0JTK6
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

694430:NATOC RS15630
gene id: 694430:NATOC_RS15630
uniprot id: L0K1X8
names: Subcellular Location Annotation
messages: Cytoplasm

694430:NATOC RS01545
gene id: 694430:NATOC_RS01545
uniprot id: L0JT54
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS00340
gene id: 694430:NATOC_RS00340
uniprot id: L0JVR9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS00660
gene id: 694430:NATOC_RS00660
uniprot id: L0JSN1
names: Similarity
messages: Belongs to the threonine aldolase family.

694430:NATOC RS17910
gene id: 694430:NATOC_RS17910
uniprot id: L0K5R7
names: Similarity
messages: Belongs to the glutaredoxin family. Monothiol subfamily.

694430:NATOC RS01305
gene id: 694430:NATOC_RS01305
uniprot id: L0JVJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

694430:NATOC RS02130
gene id: 694430:NATOC_RS02130
uniprot id: L0JUA1
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

694430:NATOC RS15535
gene id: 694430:NATOC_RS15535
uniprot id: L0K115
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

694430:NATOC RS08635
gene id: 694430:NATOC_RS08635
uniprot id: L0JZ68
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

694430:NATOC RS17685
gene id: 694430:NATOC_RS17685
uniprot id: L0K297
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS06500
gene id: 694430:NATOC_RS06500
uniprot id: L0JWN0
names: Similarity
messages: Belongs to the acylphosphatase family.

694430:NATOC RS02600
gene id: 694430:NATOC_RS02600
uniprot id: L0JWD1
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

694430:NATOC RS06405
gene id: 694430:NATOC_RS06405
uniprot id: L0JVV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

694430:NATOC RS02670
gene id: 694430:NATOC_RS02670
uniprot id: L0JX37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

694430:NATOC RS09795
gene id: 694430:NATOC_RS09795
uniprot id: L0K0H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

694430:NATOC RS11570
gene id: 694430:NATOC_RS11570
uniprot id: L0JZK6
names: Similarity
messages: Belongs to the UPF0146 family.

694430:NATOC RS03935
gene id: 694430:NATOC_RS03935
uniprot id: L0JV70
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

694430:NATOC RS12715
gene id: 694430:NATOC_RS12715
uniprot id: L0K092
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

694430:NATOC RS14635
gene id: 694430:NATOC_RS14635
uniprot id: L0K2P5
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

694430:NATOC RS07105
gene id: 694430:NATOC_RS07105
uniprot id: L0JZM7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS11920
gene id: 694430:NATOC_RS11920
uniprot id: L0JYZ0
names: Similarity
messages: Belongs to the SUI1 family.

694430:NATOC RS10090
gene id: 694430:NATOC_RS10090
uniprot id: L0K0N2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS01110
gene id: 694430:NATOC_RS01110
uniprot id: L0JUY5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

694430:NATOC RS17830
gene id: 694430:NATOC_RS17830
uniprot id: L0K5Q1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS00030
gene id: 694430:NATOC_RS00030
uniprot id: L0JUW1
names: Similarity
messages: Belongs to the aspartokinase family.

694430:NATOC RS09415
gene id: 694430:NATOC_RS09415
uniprot id: L0JXJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

694430:NATOC RS10870
gene id: 694430:NATOC_RS10870
uniprot id: L0K117
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

694430:NATOC RS18285
gene id: 694430:NATOC_RS18285
uniprot id: L0K2K3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

694430:NATOC RS08300
gene id: 694430:NATOC_RS08300
uniprot id: L0JXP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

694430:NATOC RS06610
gene id: 694430:NATOC_RS06610
uniprot id: L0JVZ5
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

694430:NATOC RS15100
gene id: 694430:NATOC_RS15100
uniprot id: L0K3H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

694430:NATOC RS00960
gene id: 694430:NATOC_RS00960
uniprot id: L0JST3
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Part of the RNA polymerase complex.

694430:NATOC RS15420
gene id: 694430:NATOC_RS15420
uniprot id: L0K4D3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS16535
gene id: 694430:NATOC_RS16535
uniprot id: L0K491
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

694430:NATOC RS04975
gene id: 694430:NATOC_RS04975
uniprot id: L0JV44
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS13220
gene id: 694430:NATOC_RS13220
uniprot id: L0K328
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

694430:NATOC RS07400
gene id: 694430:NATOC_RS07400
uniprot id: L0JWH2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS11780
gene id: 694430:NATOC_RS11780
uniprot id: L0JYW1
names: Similarity
messages: Belongs to the PdaD family.

694430:NATOC RS12375
gene id: 694430:NATOC_RS12375
uniprot id: L0K031
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

694430:NATOC RS17360
gene id: 694430:NATOC_RS17360
uniprot id: L0K233
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

694430:NATOC RS14035
gene id: 694430:NATOC_RS14035
uniprot id: L0K0Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

694430:NATOC RS06025
gene id: 694430:NATOC_RS06025
uniprot id: L0JY98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

694430:NATOC RS15510
gene id: 694430:NATOC_RS15510
uniprot id: L0K1V6
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS18360
gene id: 694430:NATOC_RS18360
uniprot id: L0K5Z4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

694430:NATOC RS03805
gene id: 694430:NATOC_RS03805
uniprot id: L0JUE2
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

694430:NATOC RS12535
gene id: 694430:NATOC_RS12535
uniprot id: L0K1G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

694430:NATOC RS01720
gene id: 694430:NATOC_RS01720
uniprot id: L0JVB3
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.

694430:NATOC RS04645
gene id: 694430:NATOC_RS04645
uniprot id: L0JUY8
names: Similarity
messages: Belongs to the glutaredoxin family.

694430:NATOC RS16920
gene id: 694430:NATOC_RS16920
uniprot id: L0K1S8
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS07715
gene id: 694430:NATOC_RS07715
uniprot id: L0JZ98
names: Similarity
messages: Belongs to the BtpA family.

694430:NATOC RS01810
gene id: 694430:NATOC_RS01810
uniprot id: L0JWL6
names: Cofactor
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

694430:NATOC RS10500
gene id: 694430:NATOC_RS10500
uniprot id: L0JY55
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

694430:NATOC RS13605
gene id: 694430:NATOC_RS13605
uniprot id: L0K203
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gas vesicle GvpK family.
messages: Gas vesicle
messages: Vesicle

694430:NATOC RS17350
gene id: 694430:NATOC_RS17350
uniprot id: L0K480
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

694430:NATOC RS08075
gene id: 694430:NATOC_RS08075
uniprot id: L0JYW5
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS07145
gene id: 694430:NATOC_RS07145
uniprot id: L0JWC6
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

694430:NATOC RS08585
gene id: 694430:NATOC_RS08585
uniprot id: L0JZR2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

694430:NATOC RS16625
gene id: 694430:NATOC_RS16625
uniprot id: L0K1M0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

694430:NATOC RS08195
gene id: 694430:NATOC_RS08195
uniprot id: L0JZJ3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

694430:NATOC RS00755
gene id: 694430:NATOC_RS00755
uniprot id: L0JVZ6
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

694430:NATOC RS07300
gene id: 694430:NATOC_RS07300
uniprot id: L0JYG9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

694430:NATOC RS08020
gene id: 694430:NATOC_RS08020
uniprot id: L0JZF9
names: Similarity
messages: Belongs to the isochorismate synthase family.

694430:NATOC RS16580
gene id: 694430:NATOC_RS16580
uniprot id: L0K505
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

694430:NATOC RS19835
gene id: 694430:NATOC_RS19835
uniprot id: L0K3K2
names: Similarity
messages: Belongs to the selenium-binding protein family.

694430:NATOC RS08190
gene id: 694430:NATOC_RS08190
uniprot id: L0K068
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

694430:NATOC RS00260
gene id: 694430:NATOC_RS00260
uniprot id: L0JT74
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS05135
gene id: 694430:NATOC_RS05135
uniprot id: L0JXS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

694430:NATOC RS03475
gene id: 694430:NATOC_RS03475
uniprot id: L0JW91
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

694430:NATOC RS18480
gene id: 694430:NATOC_RS18480
uniprot id: L0K2N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

694430:NATOC RS18940
gene id: 694430:NATOC_RS18940
uniprot id: L0K3R3
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

694430:NATOC RS20370
gene id: 694430:NATOC_RS20370
uniprot id: L0K749
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

694430:NATOC RS20165
gene id: 694430:NATOC_RS20165
uniprot id: L0K3Q6
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

694430:NATOC RS03075
gene id: 694430:NATOC_RS03075
uniprot id: L0JU12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

694430:NATOC RS00665
gene id: 694430:NATOC_RS00665
uniprot id: L0JV77
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

694430:NATOC RS09830
gene id: 694430:NATOC_RS09830
uniprot id: L0JYM5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

694430:NATOC RS18740
gene id: 694430:NATOC_RS18740
uniprot id: L0K3M1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

694430:NATOC RS15290
gene id: 694430:NATOC_RS15290
uniprot id: L0K3M0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS07550
gene id: 694430:NATOC_RS07550
uniprot id: L0JZU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

694430:NATOC RS14485
gene id: 694430:NATOC_RS14485
uniprot id: L0K351
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

694430:NATOC RS09635
gene id: 694430:NATOC_RS09635
uniprot id: L0JYI5
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

694430:NATOC RS06515
gene id: 694430:NATOC_RS06515
uniprot id: L0JYI4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

694430:NATOC RS11100
gene id: 694430:NATOC_RS11100
uniprot id: L0K162
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

694430:NATOC RS17060
gene id: 694430:NATOC_RS17060
uniprot id: L0K4L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UppP family.
messages: Membrane

694430:NATOC RS11580
gene id: 694430:NATOC_RS11580
uniprot id: L0K260
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

694430:NATOC RS03900
gene id: 694430:NATOC_RS03900
uniprot id: L0JWH8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

694430:NATOC RS12910
gene id: 694430:NATOC_RS12910
uniprot id: L0K1M7
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

694430:NATOC RS00700
gene id: 694430:NATOC_RS00700
uniprot id: L0JTF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

694430:NATOC RS03320
gene id: 694430:NATOC_RS03320
uniprot id: L0JXF8
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

694430:NATOC RS08945
gene id: 694430:NATOC_RS08945
uniprot id: L0JZX6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

694430:NATOC RS16680
gene id: 694430:NATOC_RS16680
uniprot id: L0K3T4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT.
messages: Cytoplasm

694430:NATOC RS00725
gene id: 694430:NATOC_RS00725
uniprot id: L0JTF9
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

694430:NATOC RS16605
gene id: 694430:NATOC_RS16605
uniprot id: L0K510
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

694430:NATOC RS09240
gene id: 694430:NATOC_RS09240
uniprot id: L0JZJ0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS00250
gene id: 694430:NATOC_RS00250
uniprot id: L0JV00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

694430:NATOC RS12845
gene id: 694430:NATOC_RS12845
uniprot id: L0JZH4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group I subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

694430:NATOC RS00840
gene id: 694430:NATOC_RS00840
uniprot id: L0JUT3
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS02405
gene id: 694430:NATOC_RS02405
uniprot id: L0JVP6
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

694430:NATOC RS06165
gene id: 694430:NATOC_RS06165
uniprot id: L0JVQ7
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

694430:NATOC RS08940
gene id: 694430:NATOC_RS08940
uniprot id: L0K0K8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

694430:NATOC RS07295
gene id: 694430:NATOC_RS07295
uniprot id: L0JZ23
names: Similarity
messages: Belongs to the SDO1/SBDS family.

694430:NATOC RS17840
gene id: 694430:NATOC_RS17840
uniprot id: L0K4H6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

694430:NATOC RS13415
gene id: 694430:NATOC_RS13415
uniprot id: L0JZS2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

694430:NATOC RS06690
gene id: 694430:NATOC_RS06690
uniprot id: L0JZB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

694430:NATOC RS13440
gene id: 694430:NATOC_RS13440
uniprot id: L0JZS6
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

694430:NATOC RS02710
gene id: 694430:NATOC_RS02710
uniprot id: L0JUJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

694430:NATOC RS10365
gene id: 694430:NATOC_RS10365
uniprot id: L0K0T3
names: Similarity
messages: Belongs to the HypE family.

694430:NATOC RS07160
gene id: 694430:NATOC_RS07160
uniprot id: L0JYE9
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS06785
gene id: 694430:NATOC_RS06785
uniprot id: L0JWT2
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

694430:NATOC RS12915
gene id: 694430:NATOC_RS12915
uniprot id: L0K0C3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

694430:NATOC RS12440
gene id: 694430:NATOC_RS12440
uniprot id: L0K1Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

694430:NATOC RS10135
gene id: 694430:NATOC_RS10135
uniprot id: L0JXZ7
names: Subcellular Location Annotation
names: Subunit
messages: Monomer.
messages: Nucleus

694430:NATOC RS12290
gene id: 694430:NATOC_RS12290
uniprot id: L0K1W6
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS06595
gene id: 694430:NATOC_RS06595
uniprot id: L0JY17
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

694430:NATOC RS12610
gene id: 694430:NATOC_RS12610
uniprot id: L0K1H4
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

694430:NATOC RS20710
gene id: 694430:NATOC_RS20710
uniprot id: L0K659
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

694430:NATOC RS13570
gene id: 694430:NATOC_RS13570
uniprot id: L0K393
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CbbQ/NirQ/NorQ/GpvN family.
messages: Cytoplasm
messages: Gas vesicle
messages: Vesicle

694430:NATOC RS13245
gene id: 694430:NATOC_RS13245
uniprot id: L0K333
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

694430:NATOC RS00235
gene id: 694430:NATOC_RS00235
uniprot id: L0JT69
names: Similarity
messages: Belongs to the IMPACT family.

694430:NATOC RS08825
gene id: 694430:NATOC_RS08825
uniprot id: L0JY04
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

694430:NATOC RS19635
gene id: 694430:NATOC_RS19635
uniprot id: L0K476
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

694430:NATOC RS04995
gene id: 694430:NATOC_RS04995
uniprot id: L0JVV0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

694430:NATOC RS03595
gene id: 694430:NATOC_RS03595
uniprot id: L0JU98
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS13280
gene id: 694430:NATOC_RS13280
uniprot id: L0K1U3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

694430:NATOC RS00285
gene id: 694430:NATOC_RS00285
uniprot id: L0JT80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

694430:NATOC RS12040
gene id: 694430:NATOC_RS12040
uniprot id: L0K184
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

694430:NATOC RS15155
gene id: 694430:NATOC_RS15155
uniprot id: L0K1P9
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

694430:NATOC RS01895
gene id: 694430:NATOC_RS01895
uniprot id: L0JVF2
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

694430:NATOC RS12590
gene id: 694430:NATOC_RS12590
uniprot id: L0K069
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

694430:NATOC RS06485
gene id: 694430:NATOC_RS06485
uniprot id: L0JZ74
names: Similarity
messages: Belongs to the UPF0212 family.

694430:NATOC RS08725
gene id: 694430:NATOC_RS08725
uniprot id: L0JXY2
names: Similarity
messages: Belongs to the archease family.

694430:NATOC RS03980
gene id: 694430:NATOC_RS03980
uniprot id: L0JWJ3
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

694430:NATOC RS12585
gene id: 694430:NATOC_RS12585
uniprot id: L0K1G9
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

694430:NATOC RS19385
gene id: 694430:NATOC_RS19385
uniprot id: L0K374
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS17405
gene id: 694430:NATOC_RS17405
uniprot id: L0K5I0
names: Similarity
messages: Belongs to the catalase family.

694430:NATOC RS10170
gene id: 694430:NATOC_RS10170
uniprot id: L0JY00
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS18440
gene id: 694430:NATOC_RS18440
uniprot id: L0K5B0
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS09935
gene id: 694430:NATOC_RS09935
uniprot id: L0JXW2
names: Function
names: Similarity
messages: Belongs to the FAU-1 family.
messages: Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.

694430:NATOC RS13010
gene id: 694430:NATOC_RS13010
uniprot id: L0JZK3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

694430:NATOC RS09640
gene id: 694430:NATOC_RS09640
uniprot id: L0JXR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

694430:NATOC RS06945
gene id: 694430:NATOC_RS06945
uniprot id: L0JW65
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS18780
gene id: 694430:NATOC_RS18780
uniprot id: L0K5G7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

694430:NATOC RS00825
gene id: 694430:NATOC_RS00825
uniprot id: L0JSR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

694430:NATOC RS16030
gene id: 694430:NATOC_RS16030
uniprot id: L0K1A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

694430:NATOC RS08525
gene id: 694430:NATOC_RS08525
uniprot id: L0JXT7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

694430:NATOC RS19460
gene id: 694430:NATOC_RS19460
uniprot id: L0K396
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

694430:NATOC RS02750
gene id: 694430:NATOC_RS02750
uniprot id: L0JX51
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

694430:NATOC RS15410
gene id: 694430:NATOC_RS15410
uniprot id: L0K1U1
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.
messages: Cytoplasm

694430:NATOC RS09675
gene id: 694430:NATOC_RS09675
uniprot id: L0K0F7
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

694430:NATOC RS15430
gene id: 694430:NATOC_RS15430
uniprot id: L0K343
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS12235
gene id: 694430:NATOC_RS12235
uniprot id: L0K2K6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

694430:NATOC RS14865
gene id: 694430:NATOC_RS14865
uniprot id: L0K0P6
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

694430:NATOC RS00395
gene id: 694430:NATOC_RS00395
uniprot id: L0JUK3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

694430:NATOC RS00495
gene id: 694430:NATOC_RS00495
uniprot id: L0JUM0
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

694430:NATOC RS07835
gene id: 694430:NATOC_RS07835
uniprot id: L0JZZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

694430:NATOC RS09485
gene id: 694430:NATOC_RS09485
uniprot id: L0JXL0
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS04515
gene id: 694430:NATOC_RS04515
uniprot id: L0JVK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

694430:NATOC RS10740
gene id: 694430:NATOC_RS10740
uniprot id: L0JZ32
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

694430:NATOC RS09330
gene id: 694430:NATOC_RS09330
uniprot id: L0K060
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

694430:NATOC RS14695
gene id: 694430:NATOC_RS14695
uniprot id: L0K1G8
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS14010
gene id: 694430:NATOC_RS14010
uniprot id: L0K0Z3
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

694430:NATOC RS07340
gene id: 694430:NATOC_RS07340
uniprot id: L0JZ31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

694430:NATOC RS18125
gene id: 694430:NATOC_RS18125
uniprot id: L0K5V4
names: Similarity
messages: Belongs to the TrpF family.

694430:NATOC RS06655
gene id: 694430:NATOC_RS06655
uniprot id: L0JWQ9
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

694430:NATOC RS00155
gene id: 694430:NATOC_RS00155
uniprot id: L0JUG1
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS04700
gene id: 694430:NATOC_RS04700
uniprot id: L0JYB3
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS14710
gene id: 694430:NATOC_RS14710
uniprot id: L0K2R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

694430:NATOC RS03670
gene id: 694430:NATOC_RS03670
uniprot id: L0JUB4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

694430:NATOC RS16550
gene id: 694430:NATOC_RS16550
uniprot id: L0K1K5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

694430:NATOC RS06930
gene id: 694430:NATOC_RS06930
uniprot id: L0JYT3
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS20705
gene id: 694430:NATOC_RS20705
uniprot id: L0K6M8
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

694430:NATOC RS19795
gene id: 694430:NATOC_RS19795
uniprot id: L0K662
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gas vesicle GvpK family.
messages: Gas vesicle
messages: Vesicle

694430:NATOC RS00930
gene id: 694430:NATOC_RS00930
uniprot id: L0JW27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

694430:NATOC RS18815
gene id: 694430:NATOC_RS18815
uniprot id: L0K3N5
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

694430:NATOC RS02205
gene id: 694430:NATOC_RS02205
uniprot id: L0JUB3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

694430:NATOC RS08610
gene id: 694430:NATOC_RS08610
uniprot id: L0JZR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

694430:NATOC RS11745
gene id: 694430:NATOC_RS11745
uniprot id: L0JZP0
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

694430:NATOC RS13745
gene id: 694430:NATOC_RS13745
uniprot id: L0JZY0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

694430:NATOC RS04395
gene id: 694430:NATOC_RS04395
uniprot id: L0JUR2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

694430:NATOC RS18015
gene id: 694430:NATOC_RS18015
uniprot id: L0K5T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Membrane

694430:NATOC RS03665
gene id: 694430:NATOC_RS03665
uniprot id: L0JV16
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

694430:NATOC RS04625
gene id: 694430:NATOC_RS04625
uniprot id: L0JYA0
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

694430:NATOC RS18025
gene id: 694430:NATOC_RS18025
uniprot id: L0K4K6
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

694430:NATOC RS02760
gene id: 694430:NATOC_RS02760
uniprot id: L0JVW1
names: Similarity
messages: Belongs to the eIF-2-alpha family.

694430:NATOC RS14270
gene id: 694430:NATOC_RS14270
uniprot id: L0K152
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

694430:NATOC RS13185
gene id: 694430:NATOC_RS13185
uniprot id: L0K0H1
names: Similarity
messages: Belongs to the HypE family.

694430:NATOC RS13375
gene id: 694430:NATOC_RS13375
uniprot id: L0K2F8
names: Similarity
messages: Belongs to the glutaredoxin family.

694430:NATOC RS16805
gene id: 694430:NATOC_RS16805
uniprot id: L0K3W1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS09315
gene id: 694430:NATOC_RS09315
uniprot id: L0JY99
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

694430:NATOC RS07060
gene id: 694430:NATOC_RS07060
uniprot id: L0JYY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreD family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

694430:NATOC RS13080
gene id: 694430:NATOC_RS13080
uniprot id: L0K1Q9
names: Similarity
messages: Belongs to the acetolactate synthase small subunit family.

694430:NATOC RS06950
gene id: 694430:NATOC_RS06950
uniprot id: L0JZH6
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS08735
gene id: 694430:NATOC_RS08735
uniprot id: L0K0G8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

694430:NATOC RS00065
gene id: 694430:NATOC_RS00065
uniprot id: L0JSD6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

694430:NATOC RS08210
gene id: 694430:NATOC_RS08210
uniprot id: L0JWV5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

694430:NATOC RS07465
gene id: 694430:NATOC_RS07465
uniprot id: L0JYJ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS14975
gene id: 694430:NATOC_RS14975
uniprot id: L0K3F6
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS16620
gene id: 694430:NATOC_RS16620
uniprot id: L0K2H1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

694430:NATOC RS09725
gene id: 694430:NATOC_RS09725
uniprot id: L0K0G5
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

694430:NATOC RS11265
gene id: 694430:NATOC_RS11265
uniprot id: L0JZE6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

694430:NATOC RS02660
gene id: 694430:NATOC_RS02660
uniprot id: L0JUI8
names: Function
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: May catalyze a purine salvage reaction, the substrate is unknown.

694430:NATOC RS08355
gene id: 694430:NATOC_RS08355
uniprot id: L0JWY1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

694430:NATOC RS08105
gene id: 694430:NATOC_RS08105
uniprot id: L0JXL3
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.

694430:NATOC RS06020
gene id: 694430:NATOC_RS06020
uniprot id: L0JYZ4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

694430:NATOC RS20305
gene id: 694430:NATOC_RS20305
uniprot id: L0K5Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Mitochondrion

694430:NATOC RS03340
gene id: 694430:NATOC_RS03340
uniprot id: L0JU54
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS19390
gene id: 694430:NATOC_RS19390
uniprot id: L0K6J6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS10055
gene id: 694430:NATOC_RS10055
uniprot id: L0JXY4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS11485
gene id: 694430:NATOC_RS11485
uniprot id: L0K1D2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

694430:NATOC RS13430
gene id: 694430:NATOC_RS13430
uniprot id: L0K1W7
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

694430:NATOC RS01205
gene id: 694430:NATOC_RS01205
uniprot id: L0JV07
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

694430:NATOC RS08505
gene id: 694430:NATOC_RS08505
uniprot id: L0JX01
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

694430:NATOC RS08395
gene id: 694430:NATOC_RS08395
uniprot id: L0JZ18
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

694430:NATOC RS10395
gene id: 694430:NATOC_RS10395
uniprot id: L0JY38
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS16720
gene id: 694430:NATOC_RS16720
uniprot id: L0K532
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

694430:NATOC RS00870
gene id: 694430:NATOC_RS00870
uniprot id: L0JTI2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS08535
gene id: 694430:NATOC_RS08535
uniprot id: L0K0C9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

694430:NATOC RS17240
gene id: 694430:NATOC_RS17240
uniprot id: L0K212
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

694430:NATOC RS08145
gene id: 694430:NATOC_RS08145
uniprot id: L0JZI5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

694430:NATOC RS16365
gene id: 694430:NATOC_RS16365
uniprot id: L0K2C3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

694430:NATOC RS11170
gene id: 694430:NATOC_RS11170
uniprot id: L0JYH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

694430:NATOC RS18430
gene id: 694430:NATOC_RS18430
uniprot id: L0K2M7
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

694430:NATOC RS11785
gene id: 694430:NATOC_RS11785
uniprot id: L0K2A6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

694430:NATOC RS09765
gene id: 694430:NATOC_RS09765
uniprot id: L0JXT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

694430:NATOC RS02595
gene id: 694430:NATOC_RS02595
uniprot id: L0JX24
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

694430:NATOC RS10300
gene id: 694430:NATOC_RS10300
uniprot id: L0K066
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Part of the 30S ribosomal subunit.

694430:NATOC RS18660
gene id: 694430:NATOC_RS18660
uniprot id: L0K2R6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

694430:NATOC RS10550
gene id: 694430:NATOC_RS10550
uniprot id: L0K1I7
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

694430:NATOC RS05100
gene id: 694430:NATOC_RS05100
uniprot id: L0JV66
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

694430:NATOC RS15705
gene id: 694430:NATOC_RS15705
uniprot id: L0K1Z3
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS06210
gene id: 694430:NATOC_RS06210
uniprot id: L0JWH7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

694430:NATOC RS02910
gene id: 694430:NATOC_RS02910
uniprot id: L0JVY8
names: Subunit
messages: Homodimer.

694430:NATOC RS09005
gene id: 694430:NATOC_RS09005
uniprot id: L0JZE5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

694430:NATOC RS19140
gene id: 694430:NATOC_RS19140
uniprot id: L0K322
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS11765
gene id: 694430:NATOC_RS11765
uniprot id: L0K101
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

694430:NATOC RS16495
gene id: 694430:NATOC_RS16495
uniprot id: L0K2F0
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS16825
gene id: 694430:NATOC_RS16825
uniprot id: L0K4F0
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

694430:NATOC RS07965
gene id: 694430:NATOC_RS07965
uniprot id: L0JWR6
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
messages: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).

694430:NATOC RS16400
gene id: 694430:NATOC_RS16400
uniprot id: L0K4W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

694430:NATOC RS19855
gene id: 694430:NATOC_RS19855
uniprot id: L0K4C0
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

694430:NATOC RS09040
gene id: 694430:NATOC_RS09040
uniprot id: L0JXB3
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

694430:NATOC RS04815
gene id: 694430:NATOC_RS04815
uniprot id: L0JVR6
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

694430:NATOC RS13055
gene id: 694430:NATOC_RS13055
uniprot id: L0K1Q5
names: Similarity
messages: Belongs to the peptidase S8 family.

694430:NATOC RS03880
gene id: 694430:NATOC_RS03880
uniprot id: L0JUF7
names: Similarity
messages: Belongs to the peptidase S1C family.

694430:NATOC RS07165
gene id: 694430:NATOC_RS07165
uniprot id: L0JX36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

694430:NATOC RS03120
gene id: 694430:NATOC_RS03120
uniprot id: L0JUR8
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

694430:NATOC RS06580
gene id: 694430:NATOC_RS06580
uniprot id: L0JVZ0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS18655
gene id: 694430:NATOC_RS18655
uniprot id: L0K3K9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

694430:NATOC RS11730
gene id: 694430:NATOC_RS11730
uniprot id: L0K295
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

694430:NATOC RS17400
gene id: 694430:NATOC_RS17400
uniprot id: L0K243
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

694430:NATOC RS19210
gene id: 694430:NATOC_RS19210
uniprot id: L0K6F6
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS06570
gene id: 694430:NATOC_RS06570
uniprot id: L0JY12
names: Similarity
messages: Belongs to the phosphohexose mutase family.

694430:NATOC RS17195
gene id: 694430:NATOC_RS17195
uniprot id: L0K5F0
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

694430:NATOC RS00165
gene id: 694430:NATOC_RS00165
uniprot id: L0JSE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

694430:NATOC RS08665
gene id: 694430:NATOC_RS08665
uniprot id: L0JZ73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

694430:NATOC RS06195
gene id: 694430:NATOC_RS06195
uniprot id: L0JZ21
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

694430:NATOC RS13650
gene id: 694430:NATOC_RS13650
uniprot id: L0K2K8
names: Similarity
messages: Belongs to the glutaredoxin family.

694430:NATOC RS03685
gene id: 694430:NATOC_RS03685
uniprot id: L0JWC9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

694430:NATOC RS11695
gene id: 694430:NATOC_RS11695
uniprot id: L0JZM9
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

694430:NATOC RS06825
gene id: 694430:NATOC_RS06825
uniprot id: L0JW40
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

694430:NATOC RS07405
gene id: 694430:NATOC_RS07405
uniprot id: L0JZS5
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

694430:NATOC RS01320
gene id: 694430:NATOC_RS01320
uniprot id: L0JT12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes the NAD-dependent oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Homodimer.

694430:NATOC RS03725
gene id: 694430:NATOC_RS03725
uniprot id: L0JV31
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

694430:NATOC RS08275
gene id: 694430:NATOC_RS08275
uniprot id: L0JXP2
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase family.
messages: Binds 1 FAD per subunit.

694430:NATOC RS09160
gene id: 694430:NATOC_RS09160
uniprot id: L0JXD5
names: Cofactor
messages: Binds 1 copper ion per subunit.

694430:NATOC RS04805
gene id: 694430:NATOC_RS04805
uniprot id: L0JXM3
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

694430:NATOC RS07730
gene id: 694430:NATOC_RS07730
uniprot id: L0JWM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

694430:NATOC RS07650
gene id: 694430:NATOC_RS07650
uniprot id: L0JXC4
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS01710
gene id: 694430:NATOC_RS01710
uniprot id: L0JWJ2
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

694430:NATOC RS00265
gene id: 694430:NATOC_RS00265
uniprot id: L0JSG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

694430:NATOC RS12530
gene id: 694430:NATOC_RS12530
uniprot id: L0K204
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

694430:NATOC RS18150
gene id: 694430:NATOC_RS18150
uniprot id: L0K563
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS04325
gene id: 694430:NATOC_RS04325
uniprot id: L0JXB4
names: Similarity
messages: Belongs to the AOR/FOR family.

694430:NATOC RS04535
gene id: 694430:NATOC_RS04535
uniprot id: L0JWY0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

694430:NATOC RS12020
gene id: 694430:NATOC_RS12020
uniprot id: L0JZX2
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

694430:NATOC RS20205
gene id: 694430:NATOC_RS20205
uniprot id: L0K5W8
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

694430:NATOC RS04695
gene id: 694430:NATOC_RS04695
uniprot id: L0JUZ8
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

694430:NATOC RS00820
gene id: 694430:NATOC_RS00820
uniprot id: L0JTH2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS08700
gene id: 694430:NATOC_RS08700
uniprot id: L0JXX7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS16515
gene id: 694430:NATOC_RS16515
uniprot id: L0K3Q5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

694430:NATOC RS17110
gene id: 694430:NATOC_RS17110
uniprot id: L0K2T4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS00760
gene id: 694430:NATOC_RS00760
uniprot id: L0JV95
names: Caution
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

694430:NATOC RS02485
gene id: 694430:NATOC_RS02485
uniprot id: L0JTS0
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS07825
gene id: 694430:NATOC_RS07825
uniprot id: L0JXF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

694430:NATOC RS10645
gene id: 694430:NATOC_RS10645
uniprot id: L0K1K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

694430:NATOC RS11165
gene id: 694430:NATOC_RS11165
uniprot id: L0JZC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

694430:NATOC RS11460
gene id: 694430:NATOC_RS11460
uniprot id: L0JZI8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

694430:NATOC RS14730
gene id: 694430:NATOC_RS14730
uniprot id: L0K3B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

694430:NATOC RS11725
gene id: 694430:NATOC_RS11725
uniprot id: L0JYV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

694430:NATOC RS07290
gene id: 694430:NATOC_RS07290
uniprot id: L0JZQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

694430:NATOC RS18450
gene id: 694430:NATOC_RS18450
uniprot id: L0K3G9
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS10580
gene id: 694430:NATOC_RS10580
uniprot id: L0K0W7
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS12470
gene id: 694430:NATOC_RS12470
uniprot id: L0K1Z5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal MetE family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown.

694430:NATOC RS18505
gene id: 694430:NATOC_RS18505
uniprot id: L0K2P0
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

694430:NATOC RS05860
gene id: 694430:NATOC_RS05860
uniprot id: L0JXM4
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

694430:NATOC RS16440
gene id: 694430:NATOC_RS16440
uniprot id: L0K3N8
names: Subcellular Location Annotation
messages: Cytoplasm

694430:NATOC RS10515
gene id: 694430:NATOC_RS10515
uniprot id: L0K0A4
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

694430:NATOC RS00965
gene id: 694430:NATOC_RS00965
uniprot id: L0JW33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

694430:NATOC RS11365
gene id: 694430:NATOC_RS11365
uniprot id: L0JZG7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS09775
gene id: 694430:NATOC_RS09775
uniprot id: L0K0H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

694430:NATOC RS01520
gene id: 694430:NATOC_RS01520
uniprot id: L0JT47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

694430:NATOC RS18470
gene id: 694430:NATOC_RS18470
uniprot id: L0K4T4
names: Similarity
messages: Belongs to the SUI1 family.

694430:NATOC RS12680
gene id: 694430:NATOC_RS12680
uniprot id: L0K230
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

694430:NATOC RS12275
gene id: 694430:NATOC_RS12275
uniprot id: L0K013
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

694430:NATOC RS08440
gene id: 694430:NATOC_RS08440
uniprot id: L0JZN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

694430:NATOC RS18975
gene id: 694430:NATOC_RS18975
uniprot id: L0K6A7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

694430:NATOC RS13550
gene id: 694430:NATOC_RS13550
uniprot id: L0K2J2
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

694430:NATOC RS05485
gene id: 694430:NATOC_RS05485
uniprot id: L0JVC8
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS09440
gene id: 694430:NATOC_RS09440
uniprot id: L0JXJ6
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

694430:NATOC RS02705
gene id: 694430:NATOC_RS02705
uniprot id: L0JVV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

694430:NATOC RS16765
gene id: 694430:NATOC_RS16765
uniprot id: L0K1P7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

694430:NATOC RS09200
gene id: 694430:NATOC_RS09200
uniprot id: L0JY73
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

694430:NATOC RS20790
gene id: 694430:NATOC_RS20790
uniprot id: L0K6P3
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

694430:NATOC RS18215
gene id: 694430:NATOC_RS18215
uniprot id: L0K5X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

694430:NATOC RS06770
gene id: 694430:NATOC_RS06770
uniprot id: L0JZD5
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

694430:NATOC RS02310
gene id: 694430:NATOC_RS02310
uniprot id: L0JUC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

694430:NATOC RS17580
gene id: 694430:NATOC_RS17580
uniprot id: L0K4C6
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS16610
gene id: 694430:NATOC_RS16610
uniprot id: L0K4A9
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

694430:NATOC RS10750
gene id: 694430:NATOC_RS10750
uniprot id: L0K1M8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

694430:NATOC RS18300
gene id: 694430:NATOC_RS18300
uniprot id: L0K4Q8
names: Similarity
messages: Belongs to the manganese catalase family.

694430:NATOC RS08595
gene id: 694430:NATOC_RS08595
uniprot id: L0JXV5
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS03985
gene id: 694430:NATOC_RS03985
uniprot id: L0JV81
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

694430:NATOC RS12045
gene id: 694430:NATOC_RS12045
uniprot id: L0JZX7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS06455
gene id: 694430:NATOC_RS06455
uniprot id: L0JVW4
names: Subcellular Location Annotation
messages: Cytoplasm

694430:NATOC RS16970
gene id: 694430:NATOC_RS16970
uniprot id: L0K1T7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS03085
gene id: 694430:NATOC_RS03085
uniprot id: L0JWL9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

694430:NATOC RS02560
gene id: 694430:NATOC_RS02560
uniprot id: L0JUH2
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS02755
gene id: 694430:NATOC_RS02755
uniprot id: L0JWF7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

694430:NATOC RS00720
gene id: 694430:NATOC_RS00720
uniprot id: L0JUQ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. LysZ subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS00885
gene id: 694430:NATOC_RS00885
uniprot id: L0JVB6
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

694430:NATOC RS05795
gene id: 694430:NATOC_RS05795
uniprot id: L0JYV5
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

694430:NATOC RS20285
gene id: 694430:NATOC_RS20285
uniprot id: L0K4J1
names: Caution
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

694430:NATOC RS01145
gene id: 694430:NATOC_RS01145
uniprot id: L0JSX5
names: Similarity
messages: Belongs to the thioesterase PaaI family.

694430:NATOC RS12615
gene id: 694430:NATOC_RS12615
uniprot id: L0K074
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS14325
gene id: 694430:NATOC_RS14325
uniprot id: L0K3R0
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

694430:NATOC RS13825
gene id: 694430:NATOC_RS13825
uniprot id: L0K2P2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

694430:NATOC RS15645
gene id: 694430:NATOC_RS15645
uniprot id: L0K4H8
names: Function
messages: Part of a potassium transport system.

694430:NATOC RS19245
gene id: 694430:NATOC_RS19245
uniprot id: L0K5R3
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

694430:NATOC RS11220
gene id: 694430:NATOC_RS11220
uniprot id: L0JYJ2
names: Similarity
messages: Belongs to the AAA ATPase family.

694430:NATOC RS11160
gene id: 694430:NATOC_RS11160
uniprot id: L0K0M0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

694430:NATOC RS06085
gene id: 694430:NATOC_RS06085
uniprot id: L0JZ04
names: Similarity
messages: Belongs to the cytochrome P450 family.

694430:NATOC RS00195
gene id: 694430:NATOC_RS00195
uniprot id: L0JVP1
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

694430:NATOC RS07095
gene id: 694430:NATOC_RS07095
uniprot id: L0JX23
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS09780
gene id: 694430:NATOC_RS09780
uniprot id: L0JYL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

694430:NATOC RS20610
gene id: 694430:NATOC_RS20610
uniprot id: L0K3Z1
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

694430:NATOC RS12635
gene id: 694430:NATOC_RS12635
uniprot id: L0K1H8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

694430:NATOC RS11435
gene id: 694430:NATOC_RS11435
uniprot id: L0JZI3
names: Similarity
messages: Belongs to the peptidase S66 family.

694430:NATOC RS09135
gene id: 694430:NATOC_RS09135
uniprot id: L0K0P8
names: Similarity
messages: Belongs to the RutC family.

694430:NATOC RS03785
gene id: 694430:NATOC_RS03785
uniprot id: L0JXQ0
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS03405
gene id: 694430:NATOC_RS03405
uniprot id: L0JW77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

694430:NATOC RS16735
gene id: 694430:NATOC_RS16735
uniprot id: L0K2J1
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.

694430:NATOC RS04675
gene id: 694430:NATOC_RS04675
uniprot id: L0JYA9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

694430:NATOC RS07240
gene id: 694430:NATOC_RS07240
uniprot id: L0JZ16
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

694430:NATOC RS12005
gene id: 694430:NATOC_RS12005
uniprot id: L0K2G8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

694430:NATOC RS16290
gene id: 694430:NATOC_RS16290
uniprot id: L0K2A8
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

694430:NATOC RS19190
gene id: 694430:NATOC_RS19190
uniprot id: L0K5Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

694430:NATOC RS15325
gene id: 694430:NATOC_RS15325
uniprot id: L0K1T0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS07225
gene id: 694430:NATOC_RS07225
uniprot id: L0JX45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methylamine corrinoid protein family.
messages: Belongs to the methylaspartate mutase GlmS subunit family.
messages: Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).
messages: Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.

694430:NATOC RS12540
gene id: 694430:NATOC_RS12540
uniprot id: L0K059
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS10675
gene id: 694430:NATOC_RS10675
uniprot id: L0K1L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

694430:NATOC RS03865
gene id: 694430:NATOC_RS03865
uniprot id: L0JX08
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

694430:NATOC RS12095
gene id: 694430:NATOC_RS12095
uniprot id: L0JZY5
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

694430:NATOC RS06780
gene id: 694430:NATOC_RS06780
uniprot id: L0JY53
names: Similarity
messages: Belongs to the GcvT family.

694430:NATOC RS16690
gene id: 694430:NATOC_RS16690
uniprot id: L0K1N1
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

694430:NATOC RS11685
gene id: 694430:NATOC_RS11685
uniprot id: L0K1H5
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

694430:NATOC RS03435
gene id: 694430:NATOC_RS03435
uniprot id: L0JUX3
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

694430:NATOC RS09490
gene id: 694430:NATOC_RS09490
uniprot id: L0K0X8
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

694430:NATOC RS06590
gene id: 694430:NATOC_RS06590
uniprot id: L0JYK2
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS03630
gene id: 694430:NATOC_RS03630
uniprot id: L0JWW3
names: Similarity
messages: In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

694430:NATOC RS17770
gene id: 694430:NATOC_RS17770
uniprot id: L0K4G2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

694430:NATOC RS00875
gene id: 694430:NATOC_RS00875
uniprot id: L0JSS1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

694430:NATOC RS10085
gene id: 694430:NATOC_RS10085
uniprot id: L0K1A1
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS18845
gene id: 694430:NATOC_RS18845
uniprot id: L0K2V2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

694430:NATOC RS08930
gene id: 694430:NATOC_RS08930
uniprot id: L0JY26
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

694430:NATOC RS04050
gene id: 694430:NATOC_RS04050
uniprot id: L0JX49
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

694430:NATOC RS12420
gene id: 694430:NATOC_RS12420
uniprot id: L0K1E3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

694430:NATOC RS19295
gene id: 694430:NATOC_RS19295
uniprot id: L0K5S7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

694430:NATOC RS07710
gene id: 694430:NATOC_RS07710
uniprot id: L0JZX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

694430:NATOC RS13990
gene id: 694430:NATOC_RS13990
uniprot id: L0K040
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Membrane

694430:NATOC RS15495
gene id: 694430:NATOC_RS15495
uniprot id: L0K4E9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

694430:NATOC RS11275
gene id: 694430:NATOC_RS11275
uniprot id: L0K1Z1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

694430:NATOC RS02075
gene id: 694430:NATOC_RS02075
uniprot id: L0JVJ2
names: Similarity
messages: Belongs to the PspA/IM30 family.

694430:NATOC RS02005
gene id: 694430:NATOC_RS02005
uniprot id: L0JTJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

694430:NATOC RS07355
gene id: 694430:NATOC_RS07355
uniprot id: L0JWG2
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS18485
gene id: 694430:NATOC_RS18485
uniprot id: L0K615
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

694430:NATOC RS04820
gene id: 694430:NATOC_RS04820
uniprot id: L0JV20
names: Similarity
messages: In the C-terminal section; belongs to the complex I 49 kDa subunit family.

694430:NATOC RS17970
gene id: 694430:NATOC_RS17970
uniprot id: L0K531
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

694430:NATOC RS03830
gene id: 694430:NATOC_RS03830
uniprot id: L0JUE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

694430:NATOC RS03560
gene id: 694430:NATOC_RS03560
uniprot id: L0JU94
names: Similarity
messages: Belongs to the 2Fe2S plant-type ferredoxin family.

694430:NATOC RS00915
gene id: 694430:NATOC_RS00915
uniprot id: L0JUU5
names: Similarity
messages: Belongs to the phosphoglycerate kinase family.

694430:NATOC RS10180
gene id: 694430:NATOC_RS10180
uniprot id: L0K0P5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

694430:NATOC RS00800
gene id: 694430:NATOC_RS00800
uniprot id: L0JSQ9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS12510
gene id: 694430:NATOC_RS12510
uniprot id: L0K1F6
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

694430:NATOC RS12690
gene id: 694430:NATOC_RS12690
uniprot id: L0K088
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS09190
gene id: 694430:NATOC_RS09190
uniprot id: L0K0Q7
names: Subcellular Location Annotation
messages: Cell membrane

694430:NATOC RS05445
gene id: 694430:NATOC_RS05445
uniprot id: L0JXY8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

694430:NATOC RS01870
gene id: 694430:NATOC_RS01870
uniprot id: L0JVE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

694430:NATOC RS13300
gene id: 694430:NATOC_RS13300
uniprot id: L0K2E5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

694430:NATOC RS09020
gene id: 694430:NATOC_RS09020
uniprot id: L0K0M4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

694430:NATOC RS08605
gene id: 694430:NATOC_RS08605
uniprot id: L0K0E3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Homodimer.

694430:NATOC RS13615
gene id: 694430:NATOC_RS13615
uniprot id: L0JZV8
names: Similarity
messages: Belongs to the gas vesicle GvpA family.

694430:NATOC RS12230
gene id: 694430:NATOC_RS12230
uniprot id: L0JZ70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

694430:NATOC RS20235
gene id: 694430:NATOC_RS20235
uniprot id: L0K3S2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

694430:NATOC RS05610
gene id: 694430:NATOC_RS05610
uniprot id: L0JVF0
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

694430:NATOC RS19035
gene id: 694430:NATOC_RS19035
uniprot id: L0K551
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

694430:NATOC RS07125
gene id: 694430:NATOC_RS07125
uniprot id: L0JZN2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

694430:NATOC RS06335
gene id: 694430:NATOC_RS06335
uniprot id: L0JZ41
names: Function
messages: Part of a potassium transport system.

694430:NATOC RS04790
gene id: 694430:NATOC_RS04790
uniprot id: L0JVR0
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

694430:NATOC RS04800
gene id: 694430:NATOC_RS04800
uniprot id: L0JYC8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS00955
gene id: 694430:NATOC_RS00955
uniprot id: L0JTJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

694430:NATOC RS17735
gene id: 694430:NATOC_RS17735
uniprot id: L0K5N3
names: Subcellular Location Annotation
messages: Cytoplasm

694430:NATOC RS00765
gene id: 694430:NATOC_RS00765
uniprot id: L0JUS0
names: Subcellular Location Annotation
messages: Nucleus

694430:NATOC RS18600
gene id: 694430:NATOC_RS18600
uniprot id: L0K3J7
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

694430:NATOC RS04400
gene id: 694430:NATOC_RS04400
uniprot id: L0JY35
names: Similarity
messages: Belongs to the NodU/CmcH family.

694430:NATOC RS15770
gene id: 694430:NATOC_RS15770
uniprot id: L0K154
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

694430:NATOC RS04405
gene id: 694430:NATOC_RS04405
uniprot id: L0JXD1
names: Similarity
messages: Belongs to the peptidase M24B family.

694430:NATOC RS17975
gene id: 694430:NATOC_RS17975
uniprot id: L0K4J7
names: Function
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
messages: Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC), the main low-molecular-weight thiol compound instead of glutathione in halophilic archaea.

694430:NATOC RS08670
gene id: 694430:NATOC_RS08670
uniprot id: L0JXX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

694430:NATOC RS00715
gene id: 694430:NATOC_RS00715
uniprot id: L0JV86
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS08235
gene id: 694430:NATOC_RS08235
uniprot id: L0JWW0
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

694430:NATOC RS01325
gene id: 694430:NATOC_RS01325
uniprot id: L0JWA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

694430:NATOC RS02470
gene id: 694430:NATOC_RS02470
uniprot id: L0JX02
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

694430:NATOC RS13355
gene id: 694430:NATOC_RS13355
uniprot id: L0K1V4
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS20730
gene id: 694430:NATOC_RS20730
uniprot id: L0K6N1
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: The active site is a redox-active disulfide bond.

694430:NATOC RS09995
gene id: 694430:NATOC_RS09995
uniprot id: L0K008
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

694430:NATOC RS07615
gene id: 694430:NATOC_RS07615
uniprot id: L0JZ80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

694430:NATOC RS01005
gene id: 694430:NATOC_RS01005
uniprot id: L0JVD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

694430:NATOC RS03090
gene id: 694430:NATOC_RS03090
uniprot id: L0JW18
names: Similarity
messages: Belongs to the TrpC family.

694430:NATOC RS19160
gene id: 694430:NATOC_RS19160
uniprot id: L0K6E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

694430:NATOC RS17965
gene id: 694430:NATOC_RS17965
uniprot id: L0K5S4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

694430:NATOC RS01195
gene id: 694430:NATOC_RS01195
uniprot id: L0JW83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

694430:NATOC RS05585
gene id: 694430:NATOC_RS05585
uniprot id: L0JW55
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS10295
gene id: 694430:NATOC_RS10295
uniprot id: L0K0R9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

694430:NATOC RS04845
gene id: 694430:NATOC_RS04845
uniprot id: L0JV25
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS10530
gene id: 694430:NATOC_RS10530
uniprot id: L0K0V9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS04420
gene id: 694430:NATOC_RS04420
uniprot id: L0JUR6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

694430:NATOC RS01630
gene id: 694430:NATOC_RS01630
uniprot id: L0JWH5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

694430:NATOC RS16335
gene id: 694430:NATOC_RS16335
uniprot id: U3GLG4
names: Similarity
messages: Belongs to the SCO1/2 family.

694430:NATOC RS01345
gene id: 694430:NATOC_RS01345
uniprot id: L0JT16
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS01740
gene id: 694430:NATOC_RS01740
uniprot id: L0JVU2
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS19695
gene id: 694430:NATOC_RS19695
uniprot id: L0K6T4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

694430:NATOC RS16505
gene id: 694430:NATOC_RS16505
uniprot id: L0K4Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

694430:NATOC RS00175
gene id: 694430:NATOC_RS00175
uniprot id: L0JUY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

694430:NATOC RS01270
gene id: 694430:NATOC_RS01270
uniprot id: L0JW97
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

694430:NATOC RS11315
gene id: 694430:NATOC_RS11315
uniprot id: L0JZF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

694430:NATOC RS16795
gene id: 694430:NATOC_RS16795
uniprot id: L0K548
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

694430:NATOC RS13500
gene id: 694430:NATOC_RS13500
uniprot id: L0K2I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

694430:NATOC RS11620
gene id: 694430:NATOC_RS11620
uniprot id: L0JZL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

694430:NATOC RS08900
gene id: 694430:NATOC_RS08900
uniprot id: L0JY23
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

694430:NATOC RS17585
gene id: 694430:NATOC_RS17585
uniprot id: L0K324
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS00970
gene id: 694430:NATOC_RS00970
uniprot id: L0JVC9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

694430:NATOC RS00530
gene id: 694430:NATOC_RS00530
uniprot id: L0JSK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

694430:NATOC RS06510
gene id: 694430:NATOC_RS06510
uniprot id: L0JZ81
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS18265
gene id: 694430:NATOC_RS18265
uniprot id: L0K5Y2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

694430:NATOC RS12520
gene id: 694430:NATOC_RS12520
uniprot id: L0JZB7
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

694430:NATOC RS06680
gene id: 694430:NATOC_RS06680
uniprot id: L0JWR4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

694430:NATOC RS20225
gene id: 694430:NATOC_RS20225
uniprot id: L0K5X2
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

694430:NATOC RS03470
gene id: 694430:NATOC_RS03470
uniprot id: L0JWT8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

694430:NATOC RS16520
gene id: 694430:NATOC_RS16520
uniprot id: L0K2F5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

694430:NATOC RS10480
gene id: 694430:NATOC_RS10480
uniprot id: L0K1H0
names: Similarity
messages: Belongs to the peptidase S8 family.

694430:NATOC RS04915
gene id: 694430:NATOC_RS04915
uniprot id: L0JVT5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

694430:NATOC RS00570
gene id: 694430:NATOC_RS00570
uniprot id: L0JUN1
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

694430:NATOC RS00730
gene id: 694430:NATOC_RS00730
uniprot id: L0JSP5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family. LysK subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
messages: Cytoplasm

694430:NATOC RS12105
gene id: 694430:NATOC_RS12105
uniprot id: L0K2I9
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS01635
gene id: 694430:NATOC_RS01635
uniprot id: L0JVS0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

694430:NATOC RS16800
gene id: 694430:NATOC_RS16800
uniprot id: L0K4E5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS08570
gene id: 694430:NATOC_RS08570
uniprot id: L0JXU8
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS08640
gene id: 694430:NATOC_RS08640
uniprot id: L0JXW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

694430:NATOC RS07845
gene id: 694430:NATOC_RS07845
uniprot id: L0JYR7
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

694430:NATOC RS15425
gene id: 694430:NATOC_RS15425
uniprot id: L0K3P4
names: Similarity
messages: Belongs to the arginase family.

694430:NATOC RS15145
gene id: 694430:NATOC_RS15145
uniprot id: L0K474
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS08240
gene id: 694430:NATOC_RS08240
uniprot id: L0K077
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

694430:NATOC RS18060
gene id: 694430:NATOC_RS18060
uniprot id: L0K3A4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

694430:NATOC RS04080
gene id: 694430:NATOC_RS04080
uniprot id: L0JX55
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

694430:NATOC RS07675
gene id: 694430:NATOC_RS07675
uniprot id: L0JXC8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

694430:NATOC RS04900
gene id: 694430:NATOC_RS04900
uniprot id: L0JYE2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Lysosome

694430:NATOC RS03410
gene id: 694430:NATOC_RS03410
uniprot id: L0JUW8
names: Similarity
messages: Belongs to the Nudix hydrolase family.

694430:NATOC RS15390
gene id: 694430:NATOC_RS15390
uniprot id: L0K0Z1
names: Caution
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS08785
gene id: 694430:NATOC_RS08785
uniprot id: L0JZV0
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

694430:NATOC RS19380
gene id: 694430:NATOC_RS19380
uniprot id: L0K400
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

694430:NATOC RS12075
gene id: 694430:NATOC_RS12075
uniprot id: L0JZ45
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS03860
gene id: 694430:NATOC_RS03860
uniprot id: L0JXR6
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS12090
gene id: 694430:NATOC_RS12090
uniprot id: L0K195
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

694430:NATOC RS16525
gene id: 694430:NATOC_RS16525
uniprot id: L0K1J8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

694430:NATOC RS12365
gene id: 694430:NATOC_RS12365
uniprot id: L0K1X6
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS07075
gene id: 694430:NATOC_RS07075
uniprot id: L0JWB0
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two nickel ions.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

694430:NATOC RS19410
gene id: 694430:NATOC_RS19410
uniprot id: L0K383
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

694430:NATOC RS15330
gene id: 694430:NATOC_RS15330
uniprot id: L0K0Y3
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

694430:NATOC RS17095
gene id: 694430:NATOC_RS17095
uniprot id: L0K5D1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

694430:NATOC RS14070
gene id: 694430:NATOC_RS14070
uniprot id: L0K2U3
names: Similarity
messages: Belongs to the four-carbon acid sugar kinase family.

694430:NATOC RS19945
gene id: 694430:NATOC_RS19945
uniprot id: L0K690
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NosZ family.
messages: Homodimer.
messages: In the C-terminal section; belongs to the cytochrome c oxidase subunit 2 family.
messages: Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide.
messages: Periplasm

694430:NATOC RS03265
gene id: 694430:NATOC_RS03265
uniprot id: L0JU43
names: Similarity
messages: Belongs to the peptidase S49 family.

694430:NATOC RS11750
gene id: 694430:NATOC_RS11750
uniprot id: L0JYV6
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

694430:NATOC RS02165
gene id: 694430:NATOC_RS02165
uniprot id: L0JWV7
names: Function
messages: Part of a potassium transport system.

694430:NATOC RS11320
gene id: 694430:NATOC_RS11320
uniprot id: L0JYL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

694430:NATOC RS07795
gene id: 694430:NATOC_RS07795
uniprot id: L0JYQ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

694430:NATOC RS17825
gene id: 694430:NATOC_RS17825
uniprot id: L0K2C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

694430:NATOC RS00185
gene id: 694430:NATOC_RS00185
uniprot id: L0JT62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

694430:NATOC RS02890
gene id: 694430:NATOC_RS02890
uniprot id: L0JUM5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

694430:NATOC RS04065
gene id: 694430:NATOC_RS04065
uniprot id: L0JV93
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

694430:NATOC RS01745
gene id: 694430:NATOC_RS01745
uniprot id: L0JVC1
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS00595
gene id: 694430:NATOC_RS00595
uniprot id: L0JUN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

694430:NATOC RS06620
gene id: 694430:NATOC_RS06620
uniprot id: L0JYK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

694430:NATOC RS12695
gene id: 694430:NATOC_RS12695
uniprot id: L0JZE9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.
messages: Membrane

694430:NATOC RS19925
gene id: 694430:NATOC_RS19925
uniprot id: L0K5R9
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS08850
gene id: 694430:NATOC_RS08850
uniprot id: L0JY10
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS08660
gene id: 694430:NATOC_RS08660
uniprot id: L0JZS7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

694430:NATOC RS18075
gene id: 694430:NATOC_RS18075
uniprot id: L0K4L3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS13545
gene id: 694430:NATOC_RS13545
uniprot id: L0K387
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS02945
gene id: 694430:NATOC_RS02945
uniprot id: L0JTZ2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS10450
gene id: 694430:NATOC_RS10450
uniprot id: L0K1G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

694430:NATOC RS13400
gene id: 694430:NATOC_RS13400
uniprot id: L0K2G4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

694430:NATOC RS03970
gene id: 694430:NATOC_RS03970
uniprot id: L0JXU0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

694430:NATOC RS00985
gene id: 694430:NATOC_RS00985
uniprot id: L0JST9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

694430:NATOC RS03850
gene id: 694430:NATOC_RS03850
uniprot id: L0JV56
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

694430:NATOC RS17755
gene id: 694430:NATOC_RS17755
uniprot id: L0K2B0
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

694430:NATOC RS15650
gene id: 694430:NATOC_RS15650
uniprot id: L0K3T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

694430:NATOC RS10720
gene id: 694430:NATOC_RS10720
uniprot id: L0JY93
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

694430:NATOC RS02715
gene id: 694430:NATOC_RS02715
uniprot id: L0JTV2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS02200
gene id: 694430:NATOC_RS02200
uniprot id: L0JVL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

694430:NATOC RS09610
gene id: 694430:NATOC_RS09610
uniprot id: L0JYI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

694430:NATOC RS08205
gene id: 694430:NATOC_RS08205
uniprot id: L0JXN2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS18515
gene id: 694430:NATOC_RS18515
uniprot id: L0K5C5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

694430:NATOC RS07890
gene id: 694430:NATOC_RS07890
uniprot id: L0JYS7
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.

694430:NATOC RS12025
gene id: 694430:NATOC_RS12025
uniprot id: L0JZ37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homodimer.

694430:NATOC RS03620
gene id: 694430:NATOC_RS03620
uniprot id: L0JUA4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

694430:NATOC RS18930
gene id: 694430:NATOC_RS18930
uniprot id: L0K5J3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

694430:NATOC RS11565
gene id: 694430:NATOC_RS11565
uniprot id: L0K0W0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M54 family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.
messages: Monomer.
messages: Probable zinc metalloprotease whose natural substrate is unknown.

694430:NATOC RS12450
gene id: 694430:NATOC_RS12450
uniprot id: L0K046
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

694430:NATOC RS03000
gene id: 694430:NATOC_RS03000
uniprot id: L0JX98
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS15515
gene id: 694430:NATOC_RS15515
uniprot id: L0K110
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS02720
gene id: 694430:NATOC_RS02720
uniprot id: L0JX46
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS02955
gene id: 694430:NATOC_RS02955
uniprot id: L0JWJ5
names: Similarity
messages: Belongs to the pyruvate kinase family.
messages: In the C-terminal section; belongs to the PEP-utilizing enzyme family.

694430:NATOC RS05240
gene id: 694430:NATOC_RS05240
uniprot id: L0JVZ4
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS14890
gene id: 694430:NATOC_RS14890
uniprot id: L0K0Q0
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS14390
gene id: 694430:NATOC_RS14390
uniprot id: L0K177
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS09740
gene id: 694430:NATOC_RS09740
uniprot id: L0JXT0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

694430:NATOC RS09750
gene id: 694430:NATOC_RS09750
uniprot id: L0K0G9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS02680
gene id: 694430:NATOC_RS02680
uniprot id: L0JVU9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS01020
gene id: 694430:NATOC_RS01020
uniprot id: L0JW46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

694430:NATOC RS06585
gene id: 694430:NATOC_RS06585
uniprot id: L0JZ97
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS11345
gene id: 694430:NATOC_RS11345
uniprot id: L0JYL8
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS13495
gene id: 694430:NATOC_RS13495
uniprot id: L0K378
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS09590
gene id: 694430:NATOC_RS09590
uniprot id: L0JXQ3
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

694430:NATOC RS10305
gene id: 694430:NATOC_RS10305
uniprot id: L0JYV8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

694430:NATOC RS02685
gene id: 694430:NATOC_RS02685
uniprot id: L0JUJ3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS03780
gene id: 694430:NATOC_RS03780
uniprot id: L0JUD6
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

694430:NATOC RS02255
gene id: 694430:NATOC_RS02255
uniprot id: L0JUC1
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

694430:NATOC RS12445
gene id: 694430:NATOC_RS12445
uniprot id: L0K1E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

694430:NATOC RS11840
gene id: 694430:NATOC_RS11840
uniprot id: L0JZQ9
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

694430:NATOC RS08980
gene id: 694430:NATOC_RS08980
uniprot id: L0JY39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

694430:NATOC RS02330
gene id: 694430:NATOC_RS02330
uniprot id: L0JVN2
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS10795
gene id: 694430:NATOC_RS10795
uniprot id: L0JYA5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

694430:NATOC RS15270
gene id: 694430:NATOC_RS15270
uniprot id: L0K316
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS07990
gene id: 694430:NATOC_RS07990
uniprot id: L0JWS0
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS12265
gene id: 694430:NATOC_RS12265
uniprot id: L0K1W1
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS12355
gene id: 694430:NATOC_RS12355
uniprot id: L0JZ91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

694430:NATOC RS15120
gene id: 694430:NATOC_RS15120
uniprot id: L0K470
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

694430:NATOC RS04825
gene id: 694430:NATOC_RS04825
uniprot id: L0JYD1
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS11330
gene id: 694430:NATOC_RS11330
uniprot id: L0K1A4
names: Similarity
messages: Belongs to the PDCD5 family.

694430:NATOC RS05345
gene id: 694430:NATOC_RS05345
uniprot id: L0JVA4
names: Similarity
messages: Belongs to the thioesterase PaaI family.

694430:NATOC RS00080
gene id: 694430:NATOC_RS00080
uniprot id: L0JUE8
names: Similarity
messages: Belongs to the peptidase M20A family.

694430:NATOC RS18100
gene id: 694430:NATOC_RS18100
uniprot id: L0K4L7
names: Similarity
messages: Belongs to the Nth/MutY family.

694430:NATOC RS06320
gene id: 694430:NATOC_RS06320
uniprot id: L0JXW0
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS00505
gene id: 694430:NATOC_RS00505
uniprot id: L0JSK5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

694430:NATOC RS01255
gene id: 694430:NATOC_RS01255
uniprot id: L0JV19
names: Similarity
messages: Belongs to the peptidase S8 family.

694430:NATOC RS08655
gene id: 694430:NATOC_RS08655
uniprot id: L0K0F4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the RNA polymerase complex.

694430:NATOC RS01090
gene id: 694430:NATOC_RS01090
uniprot id: L0JTM3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EutB family.
messages: Binds between the large and small subunits.
messages: May catalyze the deamination of various vicinal amino-alcohols to oxo compounds. Would allow this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of vitamin B12.
messages: The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.

694430:NATOC RS02675
gene id: 694430:NATOC_RS02675
uniprot id: L0JWE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

694430:NATOC RS18675
gene id: 694430:NATOC_RS18675
uniprot id: L0K4X2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

694430:NATOC RS01050
gene id: 694430:NATOC_RS01050
uniprot id: L0JVF1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

694430:NATOC RS09035
gene id: 694430:NATOC_RS09035
uniprot id: L0JY49
names: Similarity
messages: Belongs to the UPF0284 family.

694430:NATOC RS08515
gene id: 694430:NATOC_RS08515
uniprot id: L0JZP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

694430:NATOC RS04360
gene id: 694430:NATOC_RS04360
uniprot id: L0JVF3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

694430:NATOC RS10430
gene id: 694430:NATOC_RS10430
uniprot id: L0K1F8
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

694430:NATOC RS04650
gene id: 694430:NATOC_RS04650
uniprot id: L0JYA4
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

694430:NATOC RS16590
gene id: 694430:NATOC_RS16590
uniprot id: L0K3S0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

694430:NATOC RS06940
gene id: 694430:NATOC_RS06940
uniprot id: L0JWW9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS15720
gene id: 694430:NATOC_RS15720
uniprot id: L0K3V0
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS03480
gene id: 694430:NATOC_RS03480
uniprot id: L0JUY4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

694430:NATOC RS03625
gene id: 694430:NATOC_RS03625
uniprot id: L0JXL9
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

694430:NATOC RS06420
gene id: 694430:NATOC_RS06420
uniprot id: L0JXX9
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS13340
gene id: 694430:NATOC_RS13340
uniprot id: L0JZQ8
names: Similarity
messages: Belongs to the UPF0045 family.

694430:NATOC RS19430
gene id: 694430:NATOC_RS19430
uniprot id: L0K409
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

694430:NATOC RS18525
gene id: 694430:NATOC_RS18525
uniprot id: L0K3I3
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

694430:NATOC RS16630
gene id: 694430:NATOC_RS16630
uniprot id: L0K515
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

694430:NATOC RS17235
gene id: 694430:NATOC_RS17235
uniprot id: L0K2W0
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

694430:NATOC RS17610
gene id: 694430:NATOC_RS17610
uniprot id: L0K327
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

694430:NATOC RS07440
gene id: 694430:NATOC_RS07440
uniprot id: L0JYJ4
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

694430:NATOC RS16585
gene id: 694430:NATOC_RS16585
uniprot id: L0K4A4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

694430:NATOC RS14875
gene id: 694430:NATOC_RS14875
uniprot id: L0K3D8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS19610
gene id: 694430:NATOC_RS19610
uniprot id: L0K3F8
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS04920
gene id: 694430:NATOC_RS04920
uniprot id: L0JV38
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.

694430:NATOC RS11630
gene id: 694430:NATOC_RS11630
uniprot id: L0K271
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

694430:NATOC RS03950
gene id: 694430:NATOC_RS03950
uniprot id: L0JX27
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

694430:NATOC RS14860
gene id: 694430:NATOC_RS14860
uniprot id: L0K1J9
names: Similarity
messages: Belongs to the GcvT family.

694430:NATOC RS02230
gene id: 694430:NATOC_RS02230
uniprot id: L0JUB8
names: Similarity
messages: Belongs to the SAICAR synthetase family.

694430:NATOC RS19020
gene id: 694430:NATOC_RS19020
uniprot id: L0K2Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

694430:NATOC RS04550
gene id: 694430:NATOC_RS04550
uniprot id: L0JY88
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

694430:NATOC RS15800
gene id: 694430:NATOC_RS15800
uniprot id: L0K4K5
names: Similarity
messages: Belongs to the GcvT family.

694430:NATOC RS01095
gene id: 694430:NATOC_RS01095
uniprot id: L0JSW3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EutC family.
messages: Binds between the large and small subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May catalyze the deamination of various vicinal amino-alcohols to oxo compounds.Would allow this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.
messages: The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.

694430:NATOC RS18850
gene id: 694430:NATOC_RS18850
uniprot id: L0K686
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

694430:NATOC RS02795
gene id: 694430:NATOC_RS02795
uniprot id: L0JTW5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS17820
gene id: 694430:NATOC_RS17820
uniprot id: L0K363
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

694430:NATOC RS17620
gene id: 694430:NATOC_RS17620
uniprot id: L0K5L2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS08620
gene id: 694430:NATOC_RS08620
uniprot id: L0JX25
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

694430:NATOC RS08070
gene id: 694430:NATOC_RS08070
uniprot id: L0JZG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

694430:NATOC RS10735
gene id: 694430:NATOC_RS10735
uniprot id: L0K0E0
names: Similarity
messages: Belongs to the UPF0215 family.

694430:NATOC RS04015
gene id: 694430:NATOC_RS04015
uniprot id: L0JUI4
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

694430:NATOC RS16685
gene id: 694430:NATOC_RS16685
uniprot id: L0K2I3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

694430:NATOC RS19330
gene id: 694430:NATOC_RS19330
uniprot id: L0K5B4
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

694430:NATOC RS15225
gene id: 694430:NATOC_RS15225
uniprot id: L0K494
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

694430:NATOC RS15975
gene id: 694430:NATOC_RS15975
uniprot id: L0K191
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

694430:NATOC RS13785
gene id: 694430:NATOC_RS13785
uniprot id: L0K241
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

694430:NATOC RS05185
gene id: 694430:NATOC_RS05185
uniprot id: L0JXT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

694430:NATOC RS13110
gene id: 694430:NATOC_RS13110
uniprot id: L0K0F8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

694430:NATOC RS16460
gene id: 694430:NATOC_RS16460
uniprot id: L0K475
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

694430:NATOC RS03080
gene id: 694430:NATOC_RS03080
uniprot id: L0JXB2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

694430:NATOC RS01035
gene id: 694430:NATOC_RS01035
uniprot id: L0JTL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

694430:NATOC RS13700
gene id: 694430:NATOC_RS13700
uniprot id: L0K3B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

694430:NATOC RS07080
gene id: 694430:NATOC_RS07080
uniprot id: L0JZM2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

694430:NATOC RS15795
gene id: 694430:NATOC_RS15795
uniprot id: L0K159
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

694430:NATOC RS14075
gene id: 694430:NATOC_RS14075
uniprot id: L0K2A5
names: Similarity
messages: Belongs to the AOR/FOR family.

694430:NATOC RS07375
gene id: 694430:NATOC_RS07375
uniprot id: L0JWG7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

694430:NATOC RS11120
gene id: 694430:NATOC_RS11120
uniprot id: L0K1W0
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS11370
gene id: 694430:NATOC_RS11370
uniprot id: L0JYM3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS13890
gene id: 694430:NATOC_RS13890
uniprot id: L0K3F5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS10335
gene id: 694430:NATOC_RS10335
uniprot id: L0JY29
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

694430:NATOC RS02125
gene id: 694430:NATOC_RS02125
uniprot id: L0JVJ9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

694430:NATOC RS17750
gene id: 694430:NATOC_RS17750
uniprot id: L0K353
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

694430:NATOC RS00935
gene id: 694430:NATOC_RS00935
uniprot id: L0JVC4
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.

694430:NATOC RS00605
gene id: 694430:NATOC_RS00605
uniprot id: L0JSM2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

694430:NATOC RS19060
gene id: 694430:NATOC_RS19060
uniprot id: L0K557
names: Similarity
messages: Belongs to the HMBS family.

694430:NATOC RS16415
gene id: 694430:NATOC_RS16415
uniprot id: L0K2D4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

694430:NATOC RS08055
gene id: 694430:NATOC_RS08055
uniprot id: L0JXK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

694430:NATOC RS16410
gene id: 694430:NATOC_RS16410
uniprot id: L0K3N3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

694430:NATOC RS07870
gene id: 694430:NATOC_RS07870
uniprot id: L0JXG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

694430:NATOC RS16665
gene id: 694430:NATOC_RS16665
uniprot id: L0K1M5
names: Similarity
messages: Belongs to the UPF0045 family.

694430:NATOC RS02570
gene id: 694430:NATOC_RS02570
uniprot id: L0JX19
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

694430:NATOC RS06640
gene id: 694430:NATOC_RS06640
uniprot id: L0JZA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

694430:NATOC RS00210
gene id: 694430:NATOC_RS00210
uniprot id: L0JT66
names: Similarity
messages: Belongs to the peptidase S9C family.

694430:NATOC RS14955
gene id: 694430:NATOC_RS14955
uniprot id: L0K1L6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS11870
gene id: 694430:NATOC_RS11870
uniprot id: L0JYX9
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

694430:NATOC RS06530
gene id: 694430:NATOC_RS06530
uniprot id: L0JVX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

694430:NATOC RS10035
gene id: 694430:NATOC_RS10035
uniprot id: L0K192
names: Similarity
messages: Belongs to the AOR/FOR family.

694430:NATOC RS18825
gene id: 694430:NATOC_RS18825
uniprot id: L0K680
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

694430:NATOC RS10545
gene id: 694430:NATOC_RS10545
uniprot id: L0JY63
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS15280
gene id: 694430:NATOC_RS15280
uniprot id: L0K0X5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS07830
gene id: 694430:NATOC_RS07830
uniprot id: L0JWP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

694430:NATOC RS11880
gene id: 694430:NATOC_RS11880
uniprot id: L0K1M3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
messages: Homodimer.
messages: Monovalent cation. The ion could be potassium.

694430:NATOC RS20785
gene id: 694430:NATOC_RS20785
uniprot id: L0K7D7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

694430:NATOC RS10490
gene id: 694430:NATOC_RS10490
uniprot id: L0K099
names: Similarity
messages: Belongs to the citrate synthase family.

694430:NATOC RS18400
gene id: 694430:NATOC_RS18400
uniprot id: L0K3F9
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS16600
gene id: 694430:NATOC_RS16600
uniprot id: L0K1L5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

694430:NATOC RS18340
gene id: 694430:NATOC_RS18340
uniprot id: L0K595
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

694430:NATOC RS13575
gene id: 694430:NATOC_RS13575
uniprot id: L0K2J6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gas vesicle GvpA family.
messages: Gas vesicle shell
messages: Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. During planktonic growth they allow positioning of the organism at a favorable depth for light or nutrient acquisition. GvpA forms the protein shell.
messages: The gas vesicle shell is 2 nm thick and consists of a single layer of this protein. It forms helical ribs nearly perpendicular to the long axis of the vesicle.

694430:NATOC RS15455
gene id: 694430:NATOC_RS15455
uniprot id: L0K347
names: Function
names: Similarity
messages: Belongs to the trehalose phosphatase family.
messages: Removes the phosphate from trehalose 6-phosphate to produce free trehalose.

694430:NATOC RS02440
gene id: 694430:NATOC_RS02440
uniprot id: L0JTR2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

694430:NATOC RS16540
gene id: 694430:NATOC_RS16540
uniprot id: L0K3Q9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

694430:NATOC RS19145
gene id: 694430:NATOC_RS19145
uniprot id: L0K6E1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

694430:NATOC RS01990
gene id: 694430:NATOC_RS01990
uniprot id: L0JW23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

694430:NATOC RS20550
gene id: 694430:NATOC_RS20550
uniprot id: L0K6K3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

694430:NATOC RS15675
gene id: 694430:NATOC_RS15675
uniprot id: L0K382
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS06810
gene id: 694430:NATOC_RS06810
uniprot id: L0JZE7
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS02740
gene id: 694430:NATOC_RS02740
uniprot id: L0JUK1
names: Subcellular Location Annotation
messages: Membrane

694430:NATOC RS19045
gene id: 694430:NATOC_RS19045
uniprot id: L0K2Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

694430:NATOC RS08445
gene id: 694430:NATOC_RS08445
uniprot id: L0JZ28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

694430:NATOC RS07700
gene id: 694430:NATOC_RS07700
uniprot id: L0JXD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

694430:NATOC RS02625
gene id: 694430:NATOC_RS02625
uniprot id: L0JWD6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

694430:NATOC RS17980
gene id: 694430:NATOC_RS17980
uniprot id: L0K391
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

694430:NATOC RS02000
gene id: 694430:NATOC_RS02000
uniprot id: L0JU75
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.

694430:NATOC RS19105
gene id: 694430:NATOC_RS19105
uniprot id: L0K5M7
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

694430:NATOC RS13460
gene id: 694430:NATOC_RS13460
uniprot id: L0K0M8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

694430:NATOC RS07390
gene id: 694430:NATOC_RS07390
uniprot id: L0JYI7
names: Similarity
messages: Belongs to the GARS family.

694430:NATOC RS06330
gene id: 694430:NATOC_RS06330
uniprot id: L0JVT4
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

694430:NATOC RS12425
gene id: 694430:NATOC_RS12425
uniprot id: L0K041
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

694430:NATOC RS17245
gene id: 694430:NATOC_RS17245
uniprot id: L0K5F6
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

694430:NATOC RS04740
gene id: 694430:NATOC_RS04740
uniprot id: L0JVQ0
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

694430:NATOC RS10570
gene id: 694430:NATOC_RS10570
uniprot id: L0JY68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

694430:NATOC RS07520
gene id: 694430:NATOC_RS07520
uniprot id: L0JXA0
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

694430:NATOC RS08200
gene id: 694430:NATOC_RS08200
uniprot id: L0JYY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

694430:NATOC RS18690
gene id: 694430:NATOC_RS18690
uniprot id: L0K3L2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

694430:NATOC RS13610
gene id: 694430:NATOC_RS13610
uniprot id: L0K0Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gas vesicle GvpF/GvpL family.
messages: Gas vesicle
messages: Vesicle

694430:NATOC RS19845
gene id: 694430:NATOC_RS19845
uniprot id: L0K672
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

694430:NATOC RS01860
gene id: 694430:NATOC_RS01860
uniprot id: L0JWM7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

694430:NATOC RS18425
gene id: 694430:NATOC_RS18425
uniprot id: L0K3G4
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.