69014:TK RS10015
gene id: 69014:TK_RS10015
uniprot id: Q5JII4
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

69014:TK RS03985
gene id: 69014:TK_RS03985
uniprot id: O74035
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.
messages: Monomer.

69014:TK RS10300
gene id: 69014:TK_RS10300
uniprot id: Q5JDQ0
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS06180
gene id: 69014:TK_RS06180
uniprot id: Q5JGJ4
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

69014:TK RS02645
gene id: 69014:TK_RS02645
uniprot id: Q5JF30
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

69014:TK RS00360
gene id: 69014:TK_RS00360
uniprot id: Q5JEI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

69014:TK RS05320
gene id: 69014:TK_RS05320
uniprot id: Q5JE32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

69014:TK RS05290
gene id: 69014:TK_RS05290
uniprot id: Q5JE04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

69014:TK RS11045
gene id: 69014:TK_RS11045
uniprot id: Q5JHM7
names: Similarity
messages: Belongs to the UPF0047 family.

69014:TK RS06105
gene id: 69014:TK_RS06105
uniprot id: Q5JGK8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Cytoplasm
messages: Homotetramer.

69014:TK RS02630
gene id: 69014:TK_RS02630
uniprot id: Q5JF34
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

69014:TK RS09465
gene id: 69014:TK_RS09465
uniprot id: Q5JER0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.

69014:TK RS03355
gene id: 69014:TK_RS03355
uniprot id: Q5JEZ6
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

69014:TK RS08015
gene id: 69014:TK_RS08015
uniprot id: Q5JIQ9
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

69014:TK RS02115
gene id: 69014:TK_RS02115
uniprot id: Q5JD31
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

69014:TK RS07800
gene id: 69014:TK_RS07800
uniprot id: Q5JIM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

69014:TK RS08320
gene id: 69014:TK_RS08320
uniprot id: Q5JIV2
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS11425
gene id: 69014:TK_RS11425
uniprot id: Q5JHU0
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

69014:TK RS05870
gene id: 69014:TK_RS05870
uniprot id: Q5JGF3
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

69014:TK RS07995
gene id: 69014:TK_RS07995
uniprot id: Q5JIR3
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

69014:TK RS02820
gene id: 69014:TK_RS02820
uniprot id: Q5JF59
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS09185
gene id: 69014:TK_RS09185
uniprot id: Q5JEL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Homotetramer.
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

69014:TK RS01715
gene id: 69014:TK_RS01715
uniprot id: Q5JCX7
names: Similarity
messages: Belongs to the band 7/mec-2 family.

69014:TK RS11595
gene id: 69014:TK_RS11595
uniprot id: Q5JDB6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

69014:TK RS09865
gene id: 69014:TK_RS09865
uniprot id: Q5JGC3
names: Similarity
messages: Belongs to the UPF0111 family.

69014:TK RS07470
gene id: 69014:TK_RS07470
uniprot id: Q5JJD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

69014:TK RS11115
gene id: 69014:TK_RS11115
uniprot id: Q5JHP8
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

69014:TK RS02880
gene id: 69014:TK_RS02880
uniprot id: Q5JFD3
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA (By similarity). Interacts with TIP (PubMed:24728986).
messages: Inhibited by interaction with the PCNA inhibitor TIP.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

69014:TK RS00950
gene id: 69014:TK_RS00950
uniprot id: Q5JFM1
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

69014:TK RS09065
gene id: 69014:TK_RS09065
uniprot id: Q5JJ85
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

69014:TK RS00770
gene id: 69014:TK_RS00770
uniprot id: Q5JFJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

69014:TK RS11590
gene id: 69014:TK_RS11590
uniprot id: Q5JDB7
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

69014:TK RS06505
gene id: 69014:TK_RS06505
uniprot id: Q5JGR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

69014:TK RS02245
gene id: 69014:TK_RS02245
uniprot id: Q5JGA9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

69014:TK RS06320
gene id: 69014:TK_RS06320
uniprot id: Q5JGN3
names: Similarity
messages: Belongs to the PDCD5 family.

69014:TK RS05910
gene id: 69014:TK_RS05910
uniprot id: Q5JGE5
names: Similarity
messages: Belongs to the RuvB family.

69014:TK RS03305
gene id: 69014:TK_RS03305
uniprot id: Q9V2X2
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

69014:TK RS07020
gene id: 69014:TK_RS07020
uniprot id: Q5JH10
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.

69014:TK RS11150
gene id: 69014:TK_RS11150
uniprot id: Q5JHP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

69014:TK RS11420
gene id: 69014:TK_RS11420
uniprot id: Q5JHU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

69014:TK RS04320
gene id: 69014:TK_RS04320
uniprot id: Q5JI44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

69014:TK RS03895
gene id: 69014:TK_RS03895
uniprot id: Q5JH93
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the inositol monophosphatase superfamily. FBPase class 4 family.
messages: Constitutively expressed, at a very weak level.
messages: Disruption of this gene does not lead to any detectable phenotypic changes regarding the growth under gluconeogenic conditions (medium supplemented with pyruvate) and glycolytic conditions (medium supplemented with soluble starch).
messages: Homodimer.
messages: Is not able to complement the defect of the fbp deletion under gluconeogenic conditions, probably due to insufficient transcription.
messages: Phosphatase with broad specificity; it can dephosphorylate fructose 1,6-bisphosphate (FBP) and inositol-1-phosphate (IMP). However, while possessing a high FBPase activity in vitro, does not participate in gluconeogenesis in vivo.

69014:TK RS11475
gene id: 69014:TK_RS11475
uniprot id: Q5JDB1
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

69014:TK RS09345
gene id: 69014:TK_RS09345
uniprot id: Q5JEQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

69014:TK RS10160
gene id: 69014:TK_RS10160
uniprot id: Q5JDD2
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS07600
gene id: 69014:TK_RS07600
uniprot id: Q5JJG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

69014:TK RS10950
gene id: 69014:TK_RS10950
uniprot id: Q5JHL2
names: Similarity
messages: Belongs to the BtpA family.

69014:TK RS10620
gene id: 69014:TK_RS10620
uniprot id: Q5JEX1
names: Similarity
messages: Belongs to the MoaD family.

69014:TK RS02685
gene id: 69014:TK_RS02685
uniprot id: Q5JF22
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

69014:TK RS00945
gene id: 69014:TK_RS00945
uniprot id: Q5JFM2
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

69014:TK RS04665
gene id: 69014:TK_RS04665
uniprot id: Q5JIA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

69014:TK RS05825
gene id: 69014:TK_RS05825
uniprot id: Q5JGD1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

69014:TK RS00890
gene id: 69014:TK_RS00890
uniprot id: Q5JFL6
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

69014:TK RS04195
gene id: 69014:TK_RS04195
uniprot id: Q5JI04
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

69014:TK RS08060
gene id: 69014:TK_RS08060
uniprot id: Q5JIQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
messages: Cytoplasm

69014:TK RS08005
gene id: 69014:TK_RS08005
uniprot id: Q5JIR1
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

69014:TK RS03040
gene id: 69014:TK_RS03040
uniprot id: Q5JDM6
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.
messages: Binds 1 zinc ion per subunit.

69014:TK RS11365
gene id: 69014:TK_RS11365
uniprot id: Q5JHR8
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

69014:TK RS04290
gene id: 69014:TK_RS04290
uniprot id: Q5JI17
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

69014:TK RS06495
gene id: 69014:TK_RS06495
uniprot id: Q5JGR5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

69014:TK RS10345
gene id: 69014:TK_RS10345
uniprot id: Q5JHX1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

69014:TK RS05625
gene id: 69014:TK_RS05625
uniprot id: Q5JE74
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

69014:TK RS07115
gene id: 69014:TK_RS07115
uniprot id: Q5JDJ9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

69014:TK RS03630
gene id: 69014:TK_RS03630
uniprot id: Q5JHE5
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

69014:TK RS08705
gene id: 69014:TK_RS08705
uniprot id: Q5JJ38
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

69014:TK RS05400
gene id: 69014:TK_RS05400
uniprot id: Q5JE50
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

69014:TK RS07550
gene id: 69014:TK_RS07550
uniprot id: Q5JJE5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

69014:TK RS08110
gene id: 69014:TK_RS08110
uniprot id: Q5JIS5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

69014:TK RS03455
gene id: 69014:TK_RS03455
uniprot id: Q5JG33
names: Similarity
messages: Belongs to the peptidase U62 family.

69014:TK RS03550
gene id: 69014:TK_RS03550
uniprot id: Q5JG79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

69014:TK RS01865
gene id: 69014:TK_RS01865
uniprot id: Q5JD03
names: Disruption Phenotype
names: Function
messages: Disruption of gene does not lead to complete Cys auxotrophy, but mutant displays a growth defect in an amino acid medium depleted of Cys.
messages: Free serine kinase that uses ADP to phosphorylate L-serine to yield O-phospho-L-serine and AMP.

69014:TK RS06335
gene id: 69014:TK_RS06335
uniprot id: Q5JGN0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

69014:TK RS10185
gene id: 69014:TK_RS10185
uniprot id: Q5JDG6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CutA family.
messages: Binds 1 copper ion in the interface between two trimers.
messages: Cytoplasm
messages: Homotrimer. The binding of the copper ion probably leads to oligomerization (By similarity).
messages: Involved in resistance toward heavy metals.

69014:TK RS05730
gene id: 69014:TK_RS05730
uniprot id: Q5JE91
names: Similarity
messages: Belongs to the peptidase S49 family.

69014:TK RS04480
gene id: 69014:TK_RS04480
uniprot id: Q5JI77
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

69014:TK RS11140
gene id: 69014:TK_RS11140
uniprot id: Q5JHP3
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

69014:TK RS03725
gene id: 69014:TK_RS03725
uniprot id: Q5JHC6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

69014:TK RS01300
gene id: 69014:TK_RS01300
uniprot id: Q5JFT1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

69014:TK RS07000
gene id: 69014:TK_RS07000
uniprot id: Q5JH14
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Binds two Mg(2+) per subunit.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome.

69014:TK RS07240
gene id: 69014:TK_RS07240
uniprot id: Q5JH42
names: Similarity
messages: Belongs to the peptidase M24B family.

69014:TK RS06500
gene id: 69014:TK_RS06500
uniprot id: Q5JGR4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

69014:TK RS03515
gene id: 69014:TK_RS03515
uniprot id: Q5JG53
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

69014:TK RS07485
gene id: 69014:TK_RS07485
uniprot id: Q5JJE2
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

69014:TK RS04005
gene id: 69014:TK_RS04005
uniprot id: Q5JH71
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

69014:TK RS11145
gene id: 69014:TK_RS11145
uniprot id: Q5JHP2
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.
messages: The intein interrupts the potential ATP-binding site.
messages: This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.

69014:TK RS04350
gene id: 69014:TK_RS04350
uniprot id: Q5JI38
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.
messages: Cells lacking this gene show to a decreased growth rate at 85 degrees Celsius and a severe growth defect at 93 degrees Celsius. This mutant accumulates N1-aminopropylagmatine and agmatine at 85 degrees Celsius.
messages: Cytoplasm
messages: In T.kodakarensis, two kinds of synthetic pathways from agmatine to spermidine are predicted. One is the pathway via putrescine (pathway I), and the other is that via N1-aminopropylagmatine (pathway II) (PubMed:20675472).
messages: Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high-temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the decarboxylation of N1-(3-aminopropyl)agmatine to yield spermidine and urea. It can also use agmatine to yield putrescine.

69014:TK RS07035
gene id: 69014:TK_RS07035
uniprot id: Q5JH36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

69014:TK RS01185
gene id: 69014:TK_RS01185
uniprot id: Q8X270
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

69014:TK RS03045
gene id: 69014:TK_RS03045
uniprot id: Q5JDM8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

69014:TK RS07555
gene id: 69014:TK_RS07555
uniprot id: Q5JJE4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

69014:TK RS05250
gene id: 69014:TK_RS05250
uniprot id: Q5JE14
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

69014:TK RS08960
gene id: 69014:TK_RS08960
uniprot id: Q5JJ73
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

69014:TK RS00145
gene id: 69014:TK_RS00145
uniprot id: Q5JED2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

69014:TK RS05815
gene id: 69014:TK_RS05815
uniprot id: Q5JGD3
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

69014:TK RS08550
gene id: 69014:TK_RS08550
uniprot id: Q5JJ03
names: Similarity
messages: Belongs to the HepT RNase toxin family.

69014:TK RS07970
gene id: 69014:TK_RS07970
uniprot id: Q5JDS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

69014:TK RS05155
gene id: 69014:TK_RS05155
uniprot id: Q5JDZ9
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

69014:TK RS01295
gene id: 69014:TK_RS01295
uniprot id: Q5JFT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

69014:TK RS01815
gene id: 69014:TK_RS01815
uniprot id: Q5JCY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

69014:TK RS04775
gene id: 69014:TK_RS04775
uniprot id: Q5JIB3
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

69014:TK RS03070
gene id: 69014:TK_RS03070
uniprot id: Q5JDM1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

69014:TK RS00475
gene id: 69014:TK_RS00475
uniprot id: Q5JEJ0
names: Similarity
messages: Belongs to the MCM family.

69014:TK RS09860
gene id: 69014:TK_RS09860
uniprot id: Q5JGC4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

69014:TK RS07440
gene id: 69014:TK_RS07440
uniprot id: Q5JJD5
names: Similarity
messages: Belongs to the FUN14 family.

69014:TK RS04170
gene id: 69014:TK_RS04170
uniprot id: Q5JI10
names: Similarity
messages: Belongs to the AOR/FOR family.

69014:TK RS08355
gene id: 69014:TK_RS08355
uniprot id: P58502
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S8 family.
messages: Has a broad substrate specificity with a slight preference to large hydrophobic amino acid residues at the P1 position.
messages: Monomer.
messages: Secreted

69014:TK RS07630
gene id: 69014:TK_RS07630
uniprot id: Q5JJG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

69014:TK RS02710
gene id: 69014:TK_RS02710
uniprot id: Q5JF49
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

69014:TK RS01020
gene id: 69014:TK_RS01020
uniprot id: Q5JFN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

69014:TK RS04630
gene id: 69014:TK_RS04630
uniprot id: Q5JI95
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS01475
gene id: 69014:TK_RS01475
uniprot id: Q5JFX3
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

69014:TK RS04625
gene id: 69014:TK_RS04625
uniprot id: Q5JI79
names: Domain
names: Function
names: Similarity
messages: Belongs to the archaeal N-glycosylase/DNA lyase (AGOG) family.
messages: Contains two alpha-helical subdomains, with the 8-oxoguanine binding site located in a cleft at their interface. Contains a helix-hairpin-helix (HhH) structural motif and a Gly/Pro-rich sequence followed by a conserved Asp (HhH-GPD motif).
messages: DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates.

69014:TK RS07050
gene id: 69014:TK_RS07050
uniprot id: Q5JH33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

69014:TK RS05620
gene id: 69014:TK_RS05620
uniprot id: Q5JE75
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

69014:TK RS01250
gene id: 69014:TK_RS01250
uniprot id: Q9YGB3
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Feedback inhibited by tryptophan.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).

69014:TK RS03840
gene id: 69014:TK_RS03840
uniprot id: Q5JHA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

69014:TK RS01225
gene id: 69014:TK_RS01225
uniprot id: Q5JFU7
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

69014:TK RS02500
gene id: 69014:TK_RS02500
uniprot id: Q5JD96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

69014:TK RS05445
gene id: 69014:TK_RS05445
uniprot id: Q68BJ6
names: Cofactor
names: Function
names: Induction
names: PTM
names: Similarity
names: Subunit
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Can also use Ni(2+), Mn(2+) and Zn(2+), to a lesser extent.
messages: Catalyzes the interconversion of glucose 1-phosphate and glucose 6-phosphate, and the interconversion of mannose 1-phosphate and mannose 6-phosphate. Also displays low activity with deoxyribose 1-phosphate and glucosamine 1-phosphate.
messages: Homotetramer.
messages: Up-regulated in the presence of starch.

69014:TK RS04620
gene id: 69014:TK_RS04620
uniprot id: Q5JI80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

69014:TK RS01440
gene id: 69014:TK_RS01440
uniprot id: Q5JFX9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

69014:TK RS05720
gene id: 69014:TK_RS05720
uniprot id: Q5JE93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

69014:TK RS06975
gene id: 69014:TK_RS06975
uniprot id: Q6F494
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

69014:TK RS03860
gene id: 69014:TK_RS03860
uniprot id: Q5JH87
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

69014:TK RS06760
gene id: 69014:TK_RS06760
uniprot id: Q5JGW1
names: Similarity
messages: Belongs to the MCM family.

69014:TK RS08840
gene id: 69014:TK_RS08840
uniprot id: Q5JJ63
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

69014:TK RS03800
gene id: 69014:TK_RS03800
uniprot id: Q5JHB2
names: Similarity
messages: Belongs to the UPF0235 family.

69014:TK RS01520
gene id: 69014:TK_RS01520
uniprot id: Q5JFZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

69014:TK RS09795
gene id: 69014:TK_RS09795
uniprot id: Q5JDN6
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA (By similarity).

69014:TK RS09645
gene id: 69014:TK_RS09645
uniprot id: Q5JET9
names: Similarity
messages: Belongs to the UPF0145 family.

69014:TK RS10190
gene id: 69014:TK_RS10190
uniprot id: Q5JDG5
names: Similarity
messages: Belongs to the UPF0215 family.

69014:TK RS02615
gene id: 69014:TK_RS02615
uniprot id: Q5JF06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

69014:TK RS06160
gene id: 69014:TK_RS06160
uniprot id: Q5JGJ7
names: Similarity
messages: Belongs to the UPF0107 family.

69014:TK RS09485
gene id: 69014:TK_RS09485
uniprot id: Q5JEQ6
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates (By similarity). Can also use adenosine as substrate to form ribose 1-phosphate (Probable).
messages: Disruption of the gene results in a large decrease in ribose 1,5-bisphosphate generation from adenosine.
messages: Homohexamer. Dimer of a homotrimer.

69014:TK RS07610
gene id: 69014:TK_RS07610
uniprot id: Q5JJG5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

69014:TK RS04950
gene id: 69014:TK_RS04950
uniprot id: Q5JIE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

69014:TK RS11465
gene id: 69014:TK_RS11465
uniprot id: Q5JDB0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

69014:TK RS06350
gene id: 69014:TK_RS06350
uniprot id: Q5JGM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C56 family.
messages: Cytoplasm
messages: Deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage. Also displays proteolytic activity.
messages: Homohexamer formed by a dimer of trimers that assemble into a hollow ring structure.

69014:TK RS07625
gene id: 69014:TK_RS07625
uniprot id: Q5JJG2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

69014:TK RS07690
gene id: 69014:TK_RS07690
uniprot id: Q5JDH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

69014:TK RS07340
gene id: 69014:TK_RS07340
uniprot id: Q5JJC5
names: Similarity
messages: Belongs to the HepT RNase toxin family.

69014:TK RS10530
gene id: 69014:TK_RS10530
uniprot id: Q5JEW1
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Disruption mutant cannot grow at all in the absence of L-proline.
messages: Homotetramer.
messages: L-ornithine aminotransferase involved in L-proline biosynthesis. Also shows high activity toward L-lysine. 2-oxoglutarate is the best amino acceptor, but 2-oxoadipate also leads to moderate activity.

69014:TK RS06545
gene id: 69014:TK_RS06545
uniprot id: Q5JGT6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

69014:TK RS11300
gene id: 69014:TK_RS11300
uniprot id: Q5JHT1
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the Ntn-hydrolase family.
messages: Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity (By similarity).
messages: Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer (By similarity).

69014:TK RS08405
gene id: 69014:TK_RS08405
uniprot id: Q5JIY6
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

69014:TK RS00955
gene id: 69014:TK_RS00955
uniprot id: Q5JFM0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

69014:TK RS00555
gene id: 69014:TK_RS00555
uniprot id: Q5JFE1
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

69014:TK RS03750
gene id: 69014:TK_RS03750
uniprot id: Q5JHC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

69014:TK RS07030
gene id: 69014:TK_RS07030
uniprot id: Q5JH09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

69014:TK RS09655
gene id: 69014:TK_RS09655
uniprot id: Q5JET7
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

69014:TK RS05325
gene id: 69014:TK_RS05325
uniprot id: Q5JE31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

69014:TK RS01310
gene id: 69014:TK_RS01310
uniprot id: Q5JFX1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

69014:TK RS06580
gene id: 69014:TK_RS06580
uniprot id: Q5JGS9
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

69014:TK RS01180
gene id: 69014:TK_RS01180
uniprot id: Q5JFS0
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

69014:TK RS10295
gene id: 69014:TK_RS10295
uniprot id: Q5JDQ1
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS06530
gene id: 69014:TK_RS06530
uniprot id: Q5JGS4
names: Similarity
messages: Belongs to the band 7/mec-2 family.

69014:TK RS04935
gene id: 69014:TK_RS04935
uniprot id: Q5JIE6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

69014:TK RS05560
gene id: 69014:TK_RS05560
uniprot id: Q5JE85
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

69014:TK RS08200
gene id: 69014:TK_RS08200
uniprot id: Q5JIU3
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

69014:TK RS06630
gene id: 69014:TK_RS06630
uniprot id: Q5JGV3
names: Similarity
messages: Belongs to the UPF0201 family.

69014:TK RS10450
gene id: 69014:TK_RS10450
uniprot id: Q5JHV1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

69014:TK RS03130
gene id: 69014:TK_RS03130
uniprot id: Q5JF95
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

69014:TK RS02290
gene id: 69014:TK_RS02290
uniprot id: Q5JGA0
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

69014:TK RS10645
gene id: 69014:TK_RS10645
uniprot id: Q5JEW6
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS09850
gene id: 69014:TK_RS09850
uniprot id: Q5JGC6
names: Similarity
messages: Belongs to the class-I fumarase family.

69014:TK RS07560
gene id: 69014:TK_RS07560
uniprot id: Q5JJE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

69014:TK RS03680
gene id: 69014:TK_RS03680
uniprot id: Q5JHD5
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS07480
gene id: 69014:TK_RS07480
uniprot id: Q5JJC9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

69014:TK RS10030
gene id: 69014:TK_RS10030
uniprot id: Q5JII1
names: Similarity
messages: Belongs to the HypD family.

69014:TK RS07315
gene id: 69014:TK_RS07315
uniprot id: Q76CZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).

69014:TK RS06600
gene id: 69014:TK_RS06600
uniprot id: Q5JGS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

69014:TK RS00140
gene id: 69014:TK_RS00140
uniprot id: Q5JED3
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

69014:TK RS03115
gene id: 69014:TK_RS03115
uniprot id: Q5JF98
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

69014:TK RS04200
gene id: 69014:TK_RS04200
uniprot id: Q5JI02
names: Similarity
messages: Belongs to the UPF0284 family.

69014:TK RS10070
gene id: 69014:TK_RS10070
uniprot id: Q5JIH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
messages: Monomer and homodimer. Could also form hexamers (PubMed:19769985). Forms a complex with HypB (PubMed:26056269).

69014:TK RS10660
gene id: 69014:TK_RS10660
uniprot id: Q5JEW3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

69014:TK RS08855
gene id: 69014:TK_RS08855
uniprot id: Q5JJ60
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

69014:TK RS01195
gene id: 69014:TK_RS01195
uniprot id: Q5JFR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm

69014:TK RS03385
gene id: 69014:TK_RS03385
uniprot id: Q5JG47
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-64 and Arg-67) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.

69014:TK RS00920
gene id: 69014:TK_RS00920
uniprot id: Q5JFM7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

69014:TK RS07875
gene id: 69014:TK_RS07875
uniprot id: Q5JIN9
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS07670
gene id: 69014:TK_RS07670
uniprot id: Q5JDH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

69014:TK RS04985
gene id: 69014:TK_RS04985
uniprot id: Q5JJA6
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

69014:TK RS04255
gene id: 69014:TK_RS04255
uniprot id: Q5JI24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.

69014:TK RS05760
gene id: 69014:TK_RS05760
uniprot id: Q5JGC8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.
messages: The N-terminal domain is an archaea-specific tRNA-editing domain that hydrolyzes incorrectly charged L-seryl-tRNA(Thr). Catalysis of tRNA editing is performed by the charged tRNA itself.

69014:TK RS00900
gene id: 69014:TK_RS00900
uniprot id: Q5JFN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

69014:TK RS04435
gene id: 69014:TK_RS04435
uniprot id: Q5JI54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

69014:TK RS10360
gene id: 69014:TK_RS10360
uniprot id: Q5JHW8
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

69014:TK RS07845
gene id: 69014:TK_RS07845
uniprot id: Q5JIP5
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

69014:TK RS10165
gene id: 69014:TK_RS10165
uniprot id: Q5JDH0
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS05880
gene id: 69014:TK_RS05880
uniprot id: Q5JGF1
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

69014:TK RS05585
gene id: 69014:TK_RS05585
uniprot id: Q5JE80
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Archaeosine is no more detected among the modified nucleosides in tRNA fractions, but a nucleoside corresponding to q0kN can be observed.
messages: Belongs to the radical SAM superfamily. RaSEA family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Forms a robust complex with the archaeosine synthase alpha subunit ArcS, likely an alpha(2)beta(2) heterotetrameric structure.
messages: Radical SAM enzyme involved in the synthesis of archaeosine, a modified nucleoside present in the dihydrouridine loop (D-loop) of archaeal tRNAs. Catalyzes the cleavage of the C(epsilon)-N bond of the lysine moiety of q0kN15-tRNA, leading to the formation of archaeosine at position 15 in tRNAs.

69014:TK RS04470
gene id: 69014:TK_RS04470
uniprot id: Q5JI47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

69014:TK RS03530
gene id: 69014:TK_RS03530
uniprot id: Q5JG50
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS09095
gene id: 69014:TK_RS09095
uniprot id: Q5JDW2
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS07040
gene id: 69014:TK_RS07040
uniprot id: Q5JH35
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

69014:TK RS05435
gene id: 69014:TK_RS05435
uniprot id: Q5JE43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

69014:TK RS06560
gene id: 69014:TK_RS06560
uniprot id: Q5JGT3
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

69014:TK RS00570
gene id: 69014:TK_RS00570
uniprot id: Q5JFD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

69014:TK RS07935
gene id: 69014:TK_RS07935
uniprot id: Q5JDS9
names: Similarity
messages: Belongs to the UPF0273 family.

69014:TK RS02530
gene id: 69014:TK_RS02530
uniprot id: Q76I93
names: Similarity
messages: Belongs to the pyruvate kinase family.

69014:TK RS04855
gene id: 69014:TK_RS04855
uniprot id: Q5JID0
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS07215
gene id: 69014:TK_RS07215
uniprot id: Q5JH47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

69014:TK RS01135
gene id: 69014:TK_RS01135
uniprot id: Q5JFS9
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS11195
gene id: 69014:TK_RS11195
uniprot id: Q5JHN2
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

69014:TK RS08055
gene id: 69014:TK_RS08055
uniprot id: Q5JIQ1
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.

69014:TK RS07510
gene id: 69014:TK_RS07510
uniprot id: Q5JJF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

69014:TK RS10065
gene id: 69014:TK_RS10065
uniprot id: Q5JIH4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

69014:TK RS04450
gene id: 69014:TK_RS04450
uniprot id: Q5JI51
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

69014:TK RS00970
gene id: 69014:TK_RS00970
uniprot id: Q5JFL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

69014:TK RS09880
gene id: 69014:TK_RS09880
uniprot id: Q5JGC0
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

69014:TK RS05595
gene id: 69014:TK_RS05595
uniprot id: Q5JE78
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

69014:TK RS07015
gene id: 69014:TK_RS07015
uniprot id: Q9Y8I1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compacts DNA (about 120 base pairs per nucleosome, corresponding to four histone dimers) to form nucleosome-like structures.
messages: Chromosome
messages: Cytoplasm
messages: Homodimer or heterodimer. Dimers then assemble into higher oligomers, with the DNA wrapped around the protein core. Higher order oligomerization of these structures can give rise to long, superhelical fibers (in vitro).

69014:TK RS02770
gene id: 69014:TK_RS02770
uniprot id: Q5JF37
names: Similarity
messages: Belongs to the UPF0251 family.

69014:TK RS07175
gene id: 69014:TK_RS07175
uniprot id: Q5JDJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

69014:TK RS09300
gene id: 69014:TK_RS09300
uniprot id: Q5JEM5
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS07990
gene id: 69014:TK_RS07990
uniprot id: Q5JIR4
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

69014:TK RS09770
gene id: 69014:TK_RS09770
uniprot id: Q5JDK8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

69014:TK RS07320
gene id: 69014:TK_RS07320
uniprot id: Q5JH55
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

69014:TK RS03695
gene id: 69014:TK_RS03695
uniprot id: Q5JHD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

69014:TK RS09845
gene id: 69014:TK_RS09845
uniprot id: Q5JGC7
names: Similarity
messages: Belongs to the malic enzymes family.

69014:TK RS04270
gene id: 69014:TK_RS04270
uniprot id: Q5JI21
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

69014:TK RS07195
gene id: 69014:TK_RS07195
uniprot id: Q5JH51
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal MetE family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown.

69014:TK RS00935
gene id: 69014:TK_RS00935
uniprot id: Q5JFM4
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

69014:TK RS01060
gene id: 69014:TK_RS01060
uniprot id: Q5JFR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

69014:TK RS05080
gene id: 69014:TK_RS05080
uniprot id: Q5JDX5
names: Similarity
messages: Belongs to the HypE family.

69014:TK RS08845
gene id: 69014:TK_RS08845
uniprot id: Q5JJ62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

69014:TK RS06535
gene id: 69014:TK_RS06535
uniprot id: Q5JGT8
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS11030
gene id: 69014:TK_RS11030
uniprot id: Q5JHN0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

69014:TK RS07155
gene id: 69014:TK_RS07155
uniprot id: Q5JDJ5
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

69014:TK RS04805
gene id: 69014:TK_RS04805
uniprot id: Q5JIE0
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

69014:TK RS04260
gene id: 69014:TK_RS04260
uniprot id: Q5JI23
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

69014:TK RS10845
gene id: 69014:TK_RS10845
uniprot id: Q5JHG5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the carbamate kinase family.
messages: Cytoplasm
messages: Homodimer.

69014:TK RS01200
gene id: 69014:TK_RS01200
uniprot id: Q5JFR5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

69014:TK RS04010
gene id: 69014:TK_RS04010
uniprot id: Q5JH70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

69014:TK RS04295
gene id: 69014:TK_RS04295
uniprot id: Q5JI16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.

69014:TK RS02270
gene id: 69014:TK_RS02270
uniprot id: Q5JGA4
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

69014:TK RS09260
gene id: 69014:TK_RS09260
uniprot id: Q5JEN3
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

69014:TK RS10795
gene id: 69014:TK_RS10795
uniprot id: Q5JHH4
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS08990
gene id: 69014:TK_RS08990
uniprot id: O08467
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
messages: Carries out the ATP-dependent synthesis of glutamine from ammonium nitrogen and glutamate. Exhibits both L-gamma-glutamylhydroxamate synthetase and gamma-glutamyltransferase activities when using hydroxylamine as substrate; in fact, the enzyme possesses low biosynthetic activity, suggesting that the reaction is biased towards the degradation of glutamine under ammonia-rich conditions. Might play some role in ammonia assimilation under ammonia-starvation conditions. Can also use GTP instead of ATP in the synthetase reaction, but not CTP or UTP.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.
messages: The activity of this enzyme is not controlled by adenylation.

69014:TK RS01745
gene id: 69014:TK_RS01745
uniprot id: Q5JCX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

69014:TK RS06445
gene id: 69014:TK_RS06445
uniprot id: Q5JGP4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the CoA-dependent reduction of elemental sulfur (S(0)) to produce hydrogen sulfide. Can use both NADPH and NADH, but shows a preference for NADPH (PubMed:24723088). CoA-SH may act to solubilize S(0) by forming CoA persulfides, followed by the reduction of an enzyme-S-S-CoA intermediate produced after both enzymatic and nonenzymatic evolution of H(2)S from the CoA persulfide (PubMed:24723088). Also catalyzes the oxidation of NADPH as well as NADH and predominantly converts O(2) to H(2)O, with a preference for NADPH (PubMed:23453203).
messages: Homohexamer.

69014:TK RS10825
gene id: 69014:TK_RS10825
uniprot id: Q5JHG9
names: Similarity
messages: Belongs to the UPF0175 family.

69014:TK RS05905
gene id: 69014:TK_RS05905
uniprot id: Q5JGE6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.

69014:TK RS01445
gene id: 69014:TK_RS01445
uniprot id: Q5JFX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

69014:TK RS03685
gene id: 69014:TK_RS03685
uniprot id: Q5JHD4
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

69014:TK RS00200
gene id: 69014:TK_RS00200
uniprot id: Q9V2X1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

69014:TK RS00650
gene id: 69014:TK_RS00650
uniprot id: Q52366
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

69014:TK RS09270
gene id: 69014:TK_RS09270
uniprot id: Q5JEN1
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS02765
gene id: 69014:TK_RS02765
uniprot id: Q5JF38
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

69014:TK RS04210
gene id: 69014:TK_RS04210
uniprot id: O33475
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity).

69014:TK RS03970
gene id: 69014:TK_RS03970
uniprot id: Q5JH78
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

69014:TK RS10875
gene id: 69014:TK_RS10875
uniprot id: Q8NKR9
names: Activity Regulation
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Activity is enhanced by dithioerythritol, and is slightly inhibited by fructose 2,6-bisphosphate. AMP does not inhibit the enzyme activity.
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) (PubMed:12065581, PubMed:20348906). Does not display hydrolase activity against fructose 2,6-bisphosphate, fructose 6-phosphate, fructose 1-phosphate, glucose 6-phosphate, and glucose 1-phosphate (PubMed:12065581). Exhibits only negligible activity on inositol-1-phosphate (IMP) (PubMed:15317785). Is essential for the growth of T.kodakaraensis under gluconeogenic conditions (PubMed:15317785).
messages: Cells lacking this gene cannot grow under gluconeogenic conditions while glycolytic growth is unimpaired, and the gene disruption results in the complete abolishment of intracellular FBPase activity.
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: High levels of transcripts are detected in cells grown on pyruvate or amino acids, whereas no transcription is detected when starch is present in the medium, revealing a sugar-repressed gene expression.
messages: Homooctamer; dimer of tetramers.

69014:TK RS10130
gene id: 69014:TK_RS10130
uniprot id: Q5JDD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

69014:TK RS02130
gene id: 69014:TK_RS02130
uniprot id: Q5JD27
names: Similarity
messages: Belongs to the SAICAR synthetase family.

69014:TK RS09910
gene id: 69014:TK_RS09910
uniprot id: Q5JGB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

69014:TK RS09350
gene id: 69014:TK_RS09350
uniprot id: Q5JEP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
messages: Cell membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

69014:TK RS01515
gene id: 69014:TK_RS01515
uniprot id: Q5JFZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

69014:TK RS01210
gene id: 69014:TK_RS01210
uniprot id: Q5JFV0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

69014:TK RS10755
gene id: 69014:TK_RS10755
uniprot id: Q5JHF0
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS11230
gene id: 69014:TK_RS11230
uniprot id: O52958
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activated by Co(2+) and Ni(2+) ions, however Mg(2+) ion shows almost no significant effect on the activity. Equally inhibited by ADP, CTP and GTP, while dTTP and UTP are less inhibitory.
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). It can also use CTP and GTP as substrates in addition to ATP.

69014:TK RS01255
gene id: 69014:TK_RS01255
uniprot id: Q9YGB2
names: Function
names: Subunit
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).

69014:TK RS11630
gene id: 69014:TK_RS11630
uniprot id: Q5JF00
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

69014:TK RS07535
gene id: 69014:TK_RS07535
uniprot id: Q5JJE8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

69014:TK RS05820
gene id: 69014:TK_RS05820
uniprot id: Q5JGD2
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS04695
gene id: 69014:TK_RS04695
uniprot id: Q5JI98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

69014:TK RS09925
gene id: 69014:TK_RS09925
uniprot id: Q5JIK1
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

69014:TK RS09690
gene id: 69014:TK_RS09690
uniprot id: Q5JDP5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

69014:TK RS06930
gene id: 69014:TK_RS06930
uniprot id: O93623
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the FGGY kinase family.
messages: Homodimer.
messages: It is not sensitive to fructose-1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate. Can utilize other nucleoside triphosphates (GTP, CTP, UTP and ITP) as a phosphoryl donor.

69014:TK RS10980
gene id: 69014:TK_RS10980
uniprot id: Q68BJ7
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity). Does not display phosphoglucomutase (PGM) or phosphomannomutase (PMM) activities.

69014:TK RS02325
gene id: 69014:TK_RS02325
uniprot id: Q5JD67
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: An abundant chromosomal protein that seems to be involved in both genome architecture and transcription repression. Incubation with DNA in vitro gives fibrous structures 14.2 +/- 2.1 nm in thickness (naked DNA is 1.83 +/- 0.37 nm); does not significantly compact DNA. Binds to both coding and non-coding regions; binding within gene promoters correlates with decreased transcript levels, while binding within coding regions does not.
messages: Belongs to the transcriptional regulator TrmB family.
messages: Chromosome
messages: Cytoplasm
messages: Slight growth delay compared to wild-type. No fibrous chromosomal DNA isolated from cells, DNA condensation is normal. Chromatin DNA is more sensitive to micrococcal nuclease. Alters gene expression levels of about 10% of the genome.

69014:TK RS09870
gene id: 69014:TK_RS09870
uniprot id: Q5JGC2
names: Activity Regulation
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NAD(P)H-dependent reduction of ketopantoate into pantoic acid. Prefers NADH rather than NADPH as the electron donor.
messages: Cooperative binding of CoA and ketopantoate induces a closed inhibited state by interacting with the N-terminal and C-terminal domains, and seems to facilitate the disulfide bond formation.
messages: Cytoplasm
messages: Disruption of the gene results in a strain with growth defects that are complemented by addition of pantoate.
messages: Homodimer.
messages: Regulated by feedback inhibition by coenzyme A (CoA). CoA acts by competing with NAD(P)H (PubMed:23941541, PubMed:26757028). A disulfide bond is formed between CoA and Cys-84, which indicates an irreversible inhibition upon binding of CoA (PubMed:26757028).

69014:TK RS05800
gene id: 69014:TK_RS05800
uniprot id: Q5JGD6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M54 family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.
messages: Monomer.
messages: Probable zinc metalloprotease whose natural substrate is unknown.

69014:TK RS08915
gene id: 69014:TK_RS08915
uniprot id: Q5JJ48
names: Similarity
messages: Belongs to the peptidase M20A family.

69014:TK RS05755
gene id: 69014:TK_RS05755
uniprot id: Q5JE86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

69014:TK RS07520
gene id: 69014:TK_RS07520
uniprot id: Q5JJF1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

69014:TK RS06195
gene id: 69014:TK_RS06195
uniprot id: Q5JGM4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

69014:TK RS07160
gene id: 69014:TK_RS07160
uniprot id: Q5JDJ4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

69014:TK RS11395
gene id: 69014:TK_RS11395
uniprot id: Q5JHU4
names: Similarity
messages: Belongs to the UPF0252 family.

69014:TK RS09440
gene id: 69014:TK_RS09440
uniprot id: Q5JER5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

69014:TK RS03785
gene id: 69014:TK_RS03785
uniprot id: Q5JHB5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

69014:TK RS09855
gene id: 69014:TK_RS09855
uniprot id: Q5JGC5
names: Similarity
messages: Belongs to the class-I fumarase family.

69014:TK RS07385
gene id: 69014:TK_RS07385
uniprot id: Q5JJB8
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Disruption of the gene results in a complete loss of ribose 1,5-bisphosphate generation from guanosine.
messages: Homohexamer. Dimer of a homotrimer.
messages: Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage.

69014:TK RS11335
gene id: 69014:TK_RS11335
uniprot id: Q5JHS4
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

69014:TK RS05405
gene id: 69014:TK_RS05405
uniprot id: Q5JE49
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

69014:TK RS09210
gene id: 69014:TK_RS09210
uniprot id: Q5JEL0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

69014:TK RS01780
gene id: 69014:TK_RS01780
uniprot id: Q5JCY8
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity).
messages: Belongs to the archease family.

69014:TK RS07665
gene id: 69014:TK_RS07665
uniprot id: Q5JDH6
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

69014:TK RS01370
gene id: 69014:TK_RS01370
uniprot id: Q5JFV8
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

69014:TK RS00315
gene id: 69014:TK_RS00315
uniprot id: Q5JEG3
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

69014:TK RS07065
gene id: 69014:TK_RS07065
uniprot id: Q5JH30
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

69014:TK RS03050
gene id: 69014:TK_RS03050
uniprot id: Q5JDM5
names: Function
messages: Probably involved in the biogenesis of the ribosome.

69014:TK RS05460
gene id: 69014:TK_RS05460
uniprot id: Q5JE38
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal-type GPI family.
messages: Cytoplasm
messages: Homodimer.

69014:TK RS00850
gene id: 69014:TK_RS00850
uniprot id: Q5JFK8
names: Similarity
messages: Belongs to the UPF0045 family.

69014:TK RS11530
gene id: 69014:TK_RS11530
uniprot id: Q9Y8I2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compacts DNA (about 120 base pairs per nucleosome, corresponding to four histone dimers) to form nucleosome-like structures.
messages: Chromosome
messages: Cytoplasm
messages: Homodimer or heterodimer. Dimers then assemble into higher oligomers, with the DNA wrapped around the protein core. Higher order oligomerization of these structures can give rise to long, superhelical fibers (in vitro).

69014:TK RS00215
gene id: 69014:TK_RS00215
uniprot id: Q9V2W8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

69014:TK RS07730
gene id: 69014:TK_RS07730
uniprot id: Q5JDI4
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

69014:TK RS08985
gene id: 69014:TK_RS08985
uniprot id: Q5JJ68
names: Similarity
messages: Belongs to the UPF0216 family.

69014:TK RS10735
gene id: 69014:TK_RS10735
uniprot id: Q5JHF4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

69014:TK RS10325
gene id: 69014:TK_RS10325
uniprot id: Q5JHX5
names: Similarity
messages: Belongs to the UPF0111 family.

69014:TK RS07350
gene id: 69014:TK_RS07350
uniprot id: Q5JJC3
names: Similarity
messages: Belongs to the MEMO1 family.

69014:TK RS03375
gene id: 69014:TK_RS03375
uniprot id: Q5JEZ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.
messages: Cytoplasm
messages: Homodimer.

69014:TK RS09775
gene id: 69014:TK_RS09775
uniprot id: Q5JDK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.

69014:TK RS11480
gene id: 69014:TK_RS11480
uniprot id: Q5JDA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the N-terminal section; belongs to the MobA family.
messages: Involved in biosynthesis of di-myo-inositol phosphate (DIP), a widespread organic solute in microorganisms adapted to hot environments. Catalyzes the condensation of CTP and L-myo-inositol-1-phosphate into CDP-L-myo-inositol, as well as the biosynthesis of di-myo-inositol-1,3'-phosphate-1'-phosphate (DIPP) from CDP-L-myo-inositol and L-myo-inositol-1-phosphate.
messages: Membrane

69014:TK RS04020
gene id: 69014:TK_RS04020
uniprot id: Q5JH68
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

69014:TK RS05330
gene id: 69014:TK_RS05330
uniprot id: Q5JE30
names: Similarity
messages: Belongs to the glutaredoxin family.

69014:TK RS11080
gene id: 69014:TK_RS11080
uniprot id: Q5JHM0
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

69014:TK RS00160
gene id: 69014:TK_RS00160
uniprot id: Q5JEC9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

69014:TK RS12140
gene id: 69014:TK_RS12140
uniprot id: Q5JFW2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. LysZ subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

69014:TK RS10835
gene id: 69014:TK_RS10835
uniprot id: Q5JHG7
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Archaeosine is no more detected among the modified nucleosides in tRNA fractions.
messages: Belongs to the archaeosine synthase type 1 family.
messages: Forms a robust complex with the archaeosine synthase beta subunit RaSEA, likely an alpha(2)beta(2) heterotetrameric structure. Formation of this complex highly increases lysine transfer activity.
messages: Functions in the biosynthesis of archaeosine, a modified nucleoside present in the dihydrouridine loop (D-loop) of archaeal tRNAs. Catalyzes the addition of L-lysine to the cyano group of 7-cyano-7-deazaguanine (preQ0)-modified tRNAs at position 15, to generate q0kN15-tRNA, a q0N lysine adduct identified as 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine.

69014:TK RS07495
gene id: 69014:TK_RS07495
uniprot id: Q5JJF5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

69014:TK RS04300
gene id: 69014:TK_RS04300
uniprot id: Q5JI15
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

69014:TK RS08080
gene id: 69014:TK_RS08080
uniprot id: Q5JIT2
names: Subcellular Location Annotation
messages: Nucleus

69014:TK RS03085
gene id: 69014:TK_RS03085
uniprot id: Q5JDL8
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS07400
gene id: 69014:TK_RS07400
uniprot id: Q5JJC8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

69014:TK RS04405
gene id: 69014:TK_RS04405
uniprot id: Q5JI60
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

69014:TK RS05980
gene id: 69014:TK_RS05980
uniprot id: Q5JGG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

69014:TK RS09025
gene id: 69014:TK_RS09025
uniprot id: Q5JJ93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

69014:TK RS01785
gene id: 69014:TK_RS01785
uniprot id: Q5JCY6
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.
messages: Neither activated nor inhibited by coenzyme A.

69014:TK RS10700
gene id: 69014:TK_RS10700
uniprot id: Q5JHG0
names: Subunit
messages: Homotetramer.

69014:TK RS02260
gene id: 69014:TK_RS02260
uniprot id: Q5JGA6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

69014:TK RS07490
gene id: 69014:TK_RS07490
uniprot id: Q5JJF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

69014:TK RS06885
gene id: 69014:TK_RS06885
uniprot id: Q5JH03
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

69014:TK RS11605
gene id: 69014:TK_RS11605
uniprot id: Q5JDB4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

69014:TK RS01425
gene id: 69014:TK_RS01425
uniprot id: Q5JFY2
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

69014:TK RS08870
gene id: 69014:TK_RS08870
uniprot id: Q5JJ57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

69014:TK RS05110
gene id: 69014:TK_RS05110
uniprot id: Q5JDW9
names: Function
names: Similarity
messages: Belongs to the 2-phosphoglycerate kinase family.
messages: Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.

69014:TK RS00075
gene id: 69014:TK_RS00075
uniprot id: Q5JEB7
names: Subunit
messages: Homodimer.

69014:TK RS07080
gene id: 69014:TK_RS07080
uniprot id: Q5JH27
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

69014:TK RS01220
gene id: 69014:TK_RS01220
uniprot id: Q5JFU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

69014:TK RS09940
gene id: 69014:TK_RS09940
uniprot id: Q5JIJ8
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

69014:TK RS05165
gene id: 69014:TK_RS05165
uniprot id: Q5JDZ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

69014:TK RS03360
gene id: 69014:TK_RS03360
uniprot id: Q5JEZ5
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS10900
gene id: 69014:TK_RS10900
uniprot id: Q5JHI8
names: Similarity
messages: Belongs to the peptidase U62 family.

69014:TK RS05795
gene id: 69014:TK_RS05795
uniprot id: Q5JGD7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

69014:TK RS08805
gene id: 69014:TK_RS08805
uniprot id: Q5JDT7
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

69014:TK RS07685
gene id: 69014:TK_RS07685
uniprot id: Q5JDH2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

69014:TK RS03175
gene id: 69014:TK_RS03175
uniprot id: Q5JF85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

69014:TK RS09430
gene id: 69014:TK_RS09430
uniprot id: Q5JER7
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

69014:TK RS06485
gene id: 69014:TK_RS06485
uniprot id: Q5JGR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

69014:TK RS03150
gene id: 69014:TK_RS03150
uniprot id: Q5JF90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

69014:TK RS01230
gene id: 69014:TK_RS01230
uniprot id: Q5JFU6
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

69014:TK RS02550
gene id: 69014:TK_RS02550
uniprot id: Q5JF19
names: Similarity
messages: Belongs to the UPF0166 family.

69014:TK RS02120
gene id: 69014:TK_RS02120
uniprot id: Q5JD29
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

69014:TK RS02280
gene id: 69014:TK_RS02280
uniprot id: Q5JGA2
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

69014:TK RS01035
gene id: 69014:TK_RS01035
uniprot id: Q5JFN4
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

69014:TK RS02080
gene id: 69014:TK_RS02080
uniprot id: Q5JD38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of either N(1)-methyladenine or N(1)-methylguanine at position 9 (m1A9 or m1G9) in tRNA.
messages: Cytoplasm

69014:TK RS07570
gene id: 69014:TK_RS07570
uniprot id: Q5JJH3
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS04870
gene id: 69014:TK_RS04870
uniprot id: Q8J308
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by citrate.
messages: Belongs to the DeoC/FbaB aldolase family.
messages: Cytoplasm
messages: Homooctamer.

69014:TK RS08645
gene id: 69014:TK_RS08645
uniprot id: Q5JJ15
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS09930
gene id: 69014:TK_RS09930
uniprot id: Q5JIK0
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

69014:TK RS09330
gene id: 69014:TK_RS09330
uniprot id: Q5JEL9
names: Similarity
messages: Belongs to the PstS family.

69014:TK RS00340
gene id: 69014:TK_RS00340
uniprot id: Q5JEF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

69014:TK RS09315
gene id: 69014:TK_RS09315
uniprot id: Q5JEM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

69014:TK RS08435
gene id: 69014:TK_RS08435
uniprot id: Q5JIZ5
names: Activity Regulation
names: Biotechnology
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S8 family.
messages: Has potential for application in biotechnology fields due to its high resistance to heat, denaturants, detergents and chelating agents.
messages: Monomer.
messages: Resistant to treatment with 5% SDS, 8 M urea, 10% Triton X-100 or 10% Tween-20. Fully active although less stable in the presence of 10 mM EDTA. Activity not affected by the absence or presence of 10 mM CaCl(2). Unstable in the presence of 2 M or over GdnHCl and loses 35% and 99% of its activity upon incubation with 2 and 4 M GdnHCl, respectively, for 1 hour at 55 degrees Celsius. Nearly fully loses activity upon incubation at pH 2.0.
messages: Serine protease with a broad substrate specificity.
messages: The C-terminal calcium-binding beta-jelly roll domain (445-562) of the mature domain is not required for folding or activity, but it is required for the hyperstabilization of the protein and possibly for its adaptation to high-temperature environment.

69014:TK RS00765
gene id: 69014:TK_RS00765
uniprot id: Q5JFJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

69014:TK RS10035
gene id: 69014:TK_RS10035
uniprot id: Q5JII0
names: Similarity
messages: Belongs to the HupF/HypC family.

69014:TK RS00295
gene id: 69014:TK_RS00295
uniprot id: Q5JEG7
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

69014:TK RS04225
gene id: 69014:TK_RS04225
uniprot id: Q52454
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.

69014:TK RS04495
gene id: 69014:TK_RS04495
uniprot id: Q5JI74
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

69014:TK RS07620
gene id: 69014:TK_RS07620
uniprot id: Q5JJG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

69014:TK RS00665
gene id: 69014:TK_RS00665
uniprot id: O07836
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

69014:TK RS08385
gene id: 69014:TK_RS08385
uniprot id: Q5JIX0
names: Similarity
messages: Belongs to the UPF0282 family.

69014:TK RS05410
gene id: 69014:TK_RS05410
uniprot id: Q5JE48
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

69014:TK RS05785
gene id: 69014:TK_RS05785
uniprot id: Q5JGD9
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Not essential, it can be disrupted. Cell survival is unaffected by several DNA damaging agents.

69014:TK RS07330
gene id: 69014:TK_RS07330
uniprot id: Q5JJC7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

69014:TK RS02705
gene id: 69014:TK_RS02705
uniprot id: Q5JF50
names: Similarity
messages: Belongs to the NodU/CmcH family.

69014:TK RS09505
gene id: 69014:TK_RS09505
uniprot id: Q5JET4
names: Function
names: Miscellaneous
names: PTM
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (By similarity).
messages: The intein interrupts the ATP-binding site.
messages: This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.

69014:TK RS03295
gene id: 69014:TK_RS03295
uniprot id: Q5JEY4
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

69014:TK RS05420
gene id: 69014:TK_RS05420
uniprot id: Q5JE46
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS05775
gene id: 69014:TK_RS05775
uniprot id: Q5JGE1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.

69014:TK RS02815
gene id: 69014:TK_RS02815
uniprot id: Q5JF60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

69014:TK RS03850
gene id: 69014:TK_RS03850
uniprot id: Q5JHA1
names: Similarity
messages: Belongs to the SfsA family.

69014:TK RS05535
gene id: 69014:TK_RS05535
uniprot id: Q5JE59
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

69014:TK RS00675
gene id: 69014:TK_RS00675
uniprot id: Q5JFH9
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

69014:TK RS06205
gene id: 69014:TK_RS06205
uniprot id: Q5JGM2
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

69014:TK RS07100
gene id: 69014:TK_RS07100
uniprot id: Q5JH26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

69014:TK RS08895
gene id: 69014:TK_RS08895
uniprot id: Q6I7B6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Can also use Ni(2+), Mn(2+) and Zn(2+), to a lower extent.
messages: Catalyzes the conversion of deoxyribose 1-phosphate to deoxyribose 5-phosphate. Shows also weak activity with glucose 1-phosphate and mannose 1-phosphate. Could be involved in pentose biosynthesis.
messages: Homotetramer.

69014:TK RS07580
gene id: 69014:TK_RS07580
uniprot id: Q5JJH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

69014:TK RS05315
gene id: 69014:TK_RS05315
uniprot id: Q5JE33
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

69014:TK RS07700
gene id: 69014:TK_RS07700
uniprot id: Q5JDJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

69014:TK RS05245
gene id: 69014:TK_RS05245
uniprot id: Q5JE15
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the AOR/FOR family.
messages: Binds 1 W-bis(molybdopterin guanine dinucleotide) (W-bis-MGD) cofactor per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Homodimer.

69014:TK RS04540
gene id: 69014:TK_RS04540
uniprot id: Q76KA8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

69014:TK RS04130
gene id: 69014:TK_RS04130
uniprot id: Q5JDF5
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

69014:TK RS07060
gene id: 69014:TK_RS07060
uniprot id: Q5JH31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

69014:TK RS03875
gene id: 69014:TK_RS03875
uniprot id: Q5JH96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

69014:TK RS05360
gene id: 69014:TK_RS05360
uniprot id: Q5JE24
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

69014:TK RS02560
gene id: 69014:TK_RS02560
uniprot id: Q5JF17
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Disruption of the gene results in CoA auxotrophy.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.

69014:TK RS08135
gene id: 69014:TK_RS08135
uniprot id: Q5JIS0
names: Similarity
messages: Belongs to the ZPR1 family.

69014:TK RS06310
gene id: 69014:TK_RS06310
uniprot id: Q5JGN5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

69014:TK RS07960
gene id: 69014:TK_RS07960
uniprot id: Q5JDS4
names: Function
messages: Part of a potassium transport system.

69014:TK RS04330
gene id: 69014:TK_RS04330
uniprot id: Q5JI42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

69014:TK RS05310
gene id: 69014:TK_RS05310
uniprot id: Q5JE34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

69014:TK RS11455
gene id: 69014:TK_RS11455
uniprot id: Q5JHT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

69014:TK RS03760
gene id: 69014:TK_RS03760
uniprot id: Q5JHC0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

69014:TK RS09035
gene id: 69014:TK_RS09035
uniprot id: Q5JJ91
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

69014:TK RS10100
gene id: 69014:TK_RS10100
uniprot id: Q5JDE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Membrane

69014:TK RS10420
gene id: 69014:TK_RS10420
uniprot id: Q5JHV7
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS07585
gene id: 69014:TK_RS07585
uniprot id: Q5JJH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

69014:TK RS10670
gene id: 69014:TK_RS10670
uniprot id: Q5JHE8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Disruption of the gene results in CoA auxotrophy.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

69014:TK RS08165
gene id: 69014:TK_RS08165
uniprot id: Q5JIV0
names: Similarity
messages: Belongs to the SDO1/SBDS family.

69014:TK RS01525
gene id: 69014:TK_RS01525
uniprot id: Q5JFZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

69014:TK RS07985
gene id: 69014:TK_RS07985
uniprot id: Q5JDR9
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

69014:TK RS01735
gene id: 69014:TK_RS01735
uniprot id: Q5JCX3
names: Activity Regulation
names: Domain
names: Function
names: Induction
names: Similarity
names: Subunit
messages: AMP phosphorolysis is allosterically regulated by the substrate AMP.
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP, dCMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.
messages: Constitutively expressed (at protein level). Does not respond to the addition of nucleosides.
messages: Forms an exceptionally large macromolecular structure (>40-mers) in solution.
messages: The N-terminal domain (residues 1-84), characteristic of archaeal AMPpases, is essential for enzymatic activity, participating in multimerization as well as domain closure of the active site upon substrate binding. Harbors two dimer interfaces within a single molecule: one by the central domain and the other by the C-terminal domain; these two interactions can continuously occur in a repetitive manner, leading to multimerization.

69014:TK RS03370
gene id: 69014:TK_RS03370
uniprot id: Q5JEZ3
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

69014:TK RS00830
gene id: 69014:TK_RS00830
uniprot id: Q5JFL2
names: Similarity
messages: Belongs to the GbsR family.

69014:TK RS00010
gene id: 69014:TK_RS00010
uniprot id: P77933
names: Biotechnology
names: Function
names: PTM
names: Similarity
messages: Belongs to the DNA polymerase type-B family.
messages: Has high processivity, a high polymerization rate and high fidelity. In addition to polymerase activity, also exhibits 3' to 5' exonuclease activity.
messages: Intein encoded endonucleases are thought to mediate intein mobility by site-specific recombination initiated by endonuclease cleavage at the 'homing site' in genes that lack the intein (Probable). Upon expression in E.coli PI-PkoI recognizes the minimal sequence 5'-GATTTTAGATCCCTGTACC-3' and cuts after T-10. PI-PkoII recognizes the minimal sequence 5'-CAGCTACTACGGTTAC-3' and cuts after C-10. Given the high intracellular K(+) content (>0.5 M), PI-PkoII is probably more active than PI-PkoI in vivo (PubMed:9742242).
messages: Pyrococcus kodakaraensis enzyme is a very fast, thermostable DNA polymerase (130 nucleotides/s) used in high-performance PCR.
messages: Undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.

69014:TK RS02730
gene id: 69014:TK_RS02730
uniprot id: Q5JF45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

69014:TK RS00735
gene id: 69014:TK_RS00735
uniprot id: Q5JFJ9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

69014:TK RS09310
gene id: 69014:TK_RS09310
uniprot id: Q5JEM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

69014:TK RS08160
gene id: 69014:TK_RS08160
uniprot id: Q5JIR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

69014:TK RS09800
gene id: 69014:TK_RS09800
uniprot id: Q5JDN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

69014:TK RS07325
gene id: 69014:TK_RS07325
uniprot id: Q5JJB4
names: Similarity
messages: Belongs to the CinA family.

69014:TK RS05975
gene id: 69014:TK_RS05975
uniprot id: Q5JGG6
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Activity is completely abolished in the presence of hydroxylamine, a known specific pyridoxal-phosphate inhibitor.
messages: Amino acid racemase that shows relatively high activity toward leucine, which is the preferred substrate, and methionine (PubMed:33468590). Also exhibits lower levels of activity toward phenylalanine and alanine, and trace activities toward isoleucine and valine (PubMed:33468590).
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Homotetramer.
messages: The disruption mutant displays growth in medium with L-leucine but cannot grow with D-leucine.

69014:TK RS07235
gene id: 69014:TK_RS07235
uniprot id: Q5JH43
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

69014:TK RS04810
gene id: 69014:TK_RS04810
uniprot id: Q5JID9
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

69014:TK RS08735
gene id: 69014:TK_RS08735
uniprot id: Q5JJ32
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

69014:TK RS01380
gene id: 69014:TK_RS01380
uniprot id: Q5JFV6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

69014:TK RS03390
gene id: 69014:TK_RS03390
uniprot id: Q5JG46
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

69014:TK RS00530
gene id: 69014:TK_RS00530
uniprot id: Q5JFE6
names: Similarity
messages: Belongs to the DtxR/MntR family.

69014:TK RS04730
gene id: 69014:TK_RS04730
uniprot id: Q5JIC2
names: Similarity
messages: Belongs to the HypE family.

69014:TK RS08090
gene id: 69014:TK_RS08090
uniprot id: Q5JIT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

69014:TK RS08690
gene id: 69014:TK_RS08690
uniprot id: Q5JJ41
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

69014:TK RS10120
gene id: 69014:TK_RS10120
uniprot id: Q5JDE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

69014:TK RS01625
gene id: 69014:TK_RS01625
uniprot id: Q5JG03
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

69014:TK RS03830
gene id: 69014:TK_RS03830
uniprot id: Q5JHA5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

69014:TK RS10455
gene id: 69014:TK_RS10455
uniprot id: Q5JHV0
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS05060
gene id: 69014:TK_RS05060
uniprot id: Q5JDX9
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

69014:TK RS08680
gene id: 69014:TK_RS08680
uniprot id: Q5JJ43
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

69014:TK RS07270
gene id: 69014:TK_RS07270
uniprot id: Q8NKR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

69014:TK RS08330
gene id: 69014:TK_RS08330
uniprot id: Q9HHD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

69014:TK RS07305
gene id: 69014:TK_RS07305
uniprot id: Q76CZ2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

69014:TK RS03260
gene id: 69014:TK_RS03260
uniprot id: Q5JEZ1
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS11130
gene id: 69014:TK_RS11130
uniprot id: Q5JHP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers.

69014:TK RS06990
gene id: 69014:TK_RS06990
uniprot id: Q5JH16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

69014:TK RS00135
gene id: 69014:TK_RS00135
uniprot id: Q5JED4
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

69014:TK RS00365
gene id: 69014:TK_RS00365
uniprot id: Q5JEI3
names: Similarity
messages: Belongs to the AOR/FOR family.

69014:TK RS04560
gene id: 69014:TK_RS04560
uniprot id: Q76KA7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

69014:TK RS02135
gene id: 69014:TK_RS02135
uniprot id: Q5JD26
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

69014:TK RS02725
gene id: 69014:TK_RS02725
uniprot id: Q5JF46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

69014:TK RS01650
gene id: 69014:TK_RS01650
uniprot id: Q5JG30
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

69014:TK RS03420
gene id: 69014:TK_RS03420
uniprot id: Q5JG40
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS05485
gene id: 69014:TK_RS05485
uniprot id: Q5JE68
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

69014:TK RS05705
gene id: 69014:TK_RS05705
uniprot id: Q5JE98
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

69014:TK RS06980
gene id: 69014:TK_RS06980
uniprot id: Q5JH18
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

69014:TK RS00545
gene id: 69014:TK_RS00545
uniprot id: Q5JFE3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

69014:TK RS00085
gene id: 69014:TK_RS00085
uniprot id: Q5JEB5
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

69014:TK RS10040
gene id: 69014:TK_RS10040
uniprot id: Q5JIH9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

69014:TK RS08760
gene id: 69014:TK_RS08760
uniprot id: Q5JDU6
names: Function
names: Similarity
messages: Belongs to the UPF0330 family.
messages: Possibly the antitoxin component of a type II toxin-antitoxin (TA) system.

69014:TK RS10870
gene id: 69014:TK_RS10870
uniprot id: Q5JHJ4
names: Similarity
messages: Belongs to the AOR/FOR family.

69014:TK RS06845
gene id: 69014:TK_RS06845
uniprot id: Q5JGX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

69014:TK RS07450
gene id: 69014:TK_RS07450
uniprot id: Q5JJD3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

69014:TK RS10995
gene id: 69014:TK_RS10995
uniprot id: Q5JHK3
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS01025
gene id: 69014:TK_RS01025
uniprot id: Q5JFN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

69014:TK RS05230
gene id: 69014:TK_RS05230
uniprot id: Q5JE18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

69014:TK RS07635
gene id: 69014:TK_RS07635
uniprot id: Q5JJG0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

69014:TK RS08490
gene id: 69014:TK_RS08490
uniprot id: Q5JIY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

69014:TK RS04485
gene id: 69014:TK_RS04485
uniprot id: Q5JI76
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

69014:TK RS08465
gene id: 69014:TK_RS08465
uniprot id: Q5JIY9
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Part of the 30S ribosomal subunit.

69014:TK RS08740
gene id: 69014:TK_RS08740
uniprot id: Q5JJ31
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

69014:TK RS09150
gene id: 69014:TK_RS09150
uniprot id: Q5JDV1
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

69014:TK RS10585
gene id: 69014:TK_RS10585
uniprot id: Q5JEX8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

69014:TK RS02495
gene id: 69014:TK_RS02495
uniprot id: Q5JD97
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

69014:TK RS11110
gene id: 69014:TK_RS11110
uniprot id: Q5JHN1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

69014:TK RS08470
gene id: 69014:TK_RS08470
uniprot id: Q5JIY8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

69014:TK RS04125
gene id: 69014:TK_RS04125
uniprot id: Q5JDF6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

69014:TK RS01070
gene id: 69014:TK_RS01070
uniprot id: Q5JFR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

69014:TK RS07980
gene id: 69014:TK_RS07980
uniprot id: Q5JDS0
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

69014:TK RS09080
gene id: 69014:TK_RS09080
uniprot id: Q5JJ82
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-aspartate to produce beta-alanine. In vitro, can also catalyzes the decarboxylation of L-glutamate to produce 4-aminobutanoate, but this activity does not seem necessary in vivo. Shows much higher activity with L-aspartate than with L-glutamate. Does not decarboxylate L-tyrosine.
messages: Homodimer. Can also form homohexamers.
messages: Inhibited by hydroxylamine.
messages: No growth on standard medium. Growth can be restored by the addition of exogenous beta-alanine or coenzyme A, but not by the addition of GABA.

69014:TK RS07515
gene id: 69014:TK_RS07515
uniprot id: Q5JJF2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

69014:TK RS09895
gene id: 69014:TK_RS09895
uniprot id: Q5JGB7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

69014:TK RS02520
gene id: 69014:TK_RS02520
uniprot id: Q5JD89
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

69014:TK RS00905
gene id: 69014:TK_RS00905
uniprot id: Q5JFN0
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

69014:TK RS06300
gene id: 69014:TK_RS06300
uniprot id: Q5JGN7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

69014:TK RS02800
gene id: 69014:TK_RS02800
uniprot id: Q5JF63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

69014:TK RS10095
gene id: 69014:TK_RS10095
uniprot id: Q5JDE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

69014:TK RS03485
gene id: 69014:TK_RS03485
uniprot id: Q5JG59
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

69014:TK RS00720
gene id: 69014:TK_RS00720
uniprot id: Q5JFG9
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Cells lacking this gene show decreased growth at 85 and 93 degrees Celsius. The growth rate is slightly restored at 85 degrees Celsius by the addition of spermidine, however growth at 93 degrees Celsius is not restored even when spermidine is added. This mutant accumulates agmatine at 85 degrees Celsius.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: In T.kodakarensis, two kinds of synthetic pathways from agmatine to spermidine are predicted. One is the pathway via putrescine (pathway I), and the other is that via N1-aminopropylagmatine (pathway II).
messages: Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high-temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to agmatine to yield N1-aminopropylagmatine. It can also use cadaverine (1,5-diaminopentane) and putrescine (1,4-diaminobutane) as substrate with a lower activity than that of agmatine. The reaction involves a nucleophilic attack on the C-3 methylene of the propylamine moiety adjacent to the positively charged sulfur of decarboxy-AdoMet.

69014:TK RS10805
gene id: 69014:TK_RS10805
uniprot id: Q5JHH2
names: Function
names: Similarity
messages: Belongs to the Tfx family.
messages: Putative transcriptional regulator.

69014:TK RS07465
gene id: 69014:TK_RS07465
uniprot id: Q5JJD1
names: Similarity
messages: Belongs to the enolase family.

69014:TK RS11090
gene id: 69014:TK_RS11090
uniprot id: Q5JHL8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

69014:TK RS00395
gene id: 69014:TK_RS00395
uniprot id: Q5JEH9
names: Similarity
messages: Belongs to the peptidase S8 family.

69014:TK RS04880
gene id: 69014:TK_RS04880
uniprot id: Q5JIF7
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS05050
gene id: 69014:TK_RS05050
uniprot id: Q5JDY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Homotetramer (PubMed:21761520). Homohexamer (PubMed:24684232).
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

69014:TK RS10555
gene id: 69014:TK_RS10555
uniprot id: Q5JEV6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

69014:TK RS01670
gene id: 69014:TK_RS01670
uniprot id: Q5JG26
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

69014:TK RS06025
gene id: 69014:TK_RS06025
uniprot id: Q5JGJ1
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS11360
gene id: 69014:TK_RS11360
uniprot id: Q5JHR9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

69014:TK RS07310
gene id: 69014:TK_RS07310
uniprot id: Q5JH57
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

69014:TK RS04340
gene id: 69014:TK_RS04340
uniprot id: Q5JI40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

69014:TK RS02745
gene id: 69014:TK_RS02745
uniprot id: Q5JF42
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

69014:TK RS01450
gene id: 69014:TK_RS01450
uniprot id: Q5JFX7
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

69014:TK RS07130
gene id: 69014:TK_RS07130
uniprot id: Q5JDK2
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS08485
gene id: 69014:TK_RS08485
uniprot id: Q5JIY4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

69014:TK RS07975
gene id: 69014:TK_RS07975
uniprot id: Q5JDS1
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS10650
gene id: 69014:TK_RS10650
uniprot id: Q5JEW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

69014:TK RS02320
gene id: 69014:TK_RS02320
uniprot id: Q6F598
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Binds two Mg(2+) per subunit.
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain (By similarity).
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity).
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.
messages: This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.

69014:TK RS03315
gene id: 69014:TK_RS03315
uniprot id: Q5JEY0
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

69014:TK RS06625
gene id: 69014:TK_RS06625
uniprot id: Q5JGV4
names: Similarity
messages: Belongs to the UPF0200 family.

69014:TK RS00715
gene id: 69014:TK_RS00715
uniprot id: Q5JFH0
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS01490
gene id: 69014:TK_RS01490
uniprot id: Q5JFZ7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.

69014:TK RS08885
gene id: 69014:TK_RS08885
uniprot id: Q5JJ54
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS01260
gene id: 69014:TK_RS01260
uniprot id: Q9YGB1
names: Similarity
messages: Belongs to the TrpF family.

69014:TK RS02700
gene id: 69014:TK_RS02700
uniprot id: Q5JF51
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

69014:TK RS05745
gene id: 69014:TK_RS05745
uniprot id: Q5JE88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

69014:TK RS00220
gene id: 69014:TK_RS00220
uniprot id: Q9V2W7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

69014:TK RS08410
gene id: 69014:TK_RS08410
uniprot id: Q5JIZ8
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Activity is not affected by 4'-phosphopantothenate or CoA/acetyl-CoA.
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway (PubMed:19666462, PubMed:22940806, PubMed:24638914). Cannot use (R)-pantoate as substrate and thus does not display pantothenate synthetase (PS) activity (PubMed:19666462, PubMed:22940806). Displays strict specificity for its natural substrates, 4-phosphopantoate, ATP and beta-alanine (PubMed:22940806).
messages: Homodimer.
messages: Only viable in the presence of CoA or 4'-phosphopantothenate.

69014:TK RS08170
gene id: 69014:TK_RS08170
uniprot id: Q5JIU9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

69014:TK RS05475
gene id: 69014:TK_RS05475
uniprot id: Q5JE70
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

69014:TK RS04745
gene id: 69014:TK_RS04745
uniprot id: Q5JIB9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

69014:TK RS03345
gene id: 69014:TK_RS03345
uniprot id: Q5JEZ8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane

69014:TK RS08075
gene id: 69014:TK_RS08075
uniprot id: Q5JIT3
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

69014:TK RS11545
gene id: 69014:TK_RS11545
uniprot id: Q5JDC7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

69014:TK RS03055
gene id: 69014:TK_RS03055
uniprot id: Q5JDM4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

69014:TK RS07125
gene id: 69014:TK_RS07125
uniprot id: O59650
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Cytoplasm
messages: Homohexamer.
messages: Uses both NAD and NADP.

69014:TK RS07650
gene id: 69014:TK_RS07650
uniprot id: Q5JDH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

69014:TK RS05860
gene id: 69014:TK_RS05860
uniprot id: Q5JGF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UppP family.
messages: Membrane

69014:TK RS06290
gene id: 69014:TK_RS06290
uniprot id: Q5JGN9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).

69014:TK RS10145
gene id: 69014:TK_RS10145
uniprot id: Q5JDD5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

69014:TK RS04390
gene id: 69014:TK_RS04390
uniprot id: Q5JI30
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

69014:TK RS03715
gene id: 69014:TK_RS03715
uniprot id: Q5JHC8
names: Similarity
messages: Belongs to the peptidase S9C family.

69014:TK RS03890
gene id: 69014:TK_RS03890
uniprot id: Q5JH94
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS02140
gene id: 69014:TK_RS02140
uniprot id: Q5JD25
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Despite the fact that this protein belongs to a subfamily proposed to have ribose 1,5-bisphosphate isomerase activity (PubMed:15375115), the recombinant protein does not possess this activity (PubMed:17303759). In contrast, another protein from P.kodakaraensis has been shown to display this activity (TK0185).
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.

69014:TK RS05455
gene id: 69014:TK_RS05455
uniprot id: Q5JE39
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADP-dependent glucokinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the ADP-dependent phosphorylation of D-glucose to D-glucose 6-phosphate and glucosamine to glucosamine 6-phosphate. Involved in chitin degradation.
messages: Cytoplasm
messages: Disruption of the gene severely affects growth in chitin-containing media and leads to an almost complete loss of chitin-dependent hydrogen production.

69014:TK RS04680
gene id: 69014:TK_RS04680
uniprot id: Q5JIA1
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

69014:TK RS07695
gene id: 69014:TK_RS07695
uniprot id: Q5JDI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

69014:TK RS01855
gene id: 69014:TK_RS01855
uniprot id: Q5JD05
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

69014:TK RS10180
gene id: 69014:TK_RS10180
uniprot id: Q5JDG7
names: Similarity
messages: Belongs to the acylphosphatase family.

69014:TK RS03980
gene id: 69014:TK_RS03980
uniprot id: Q5JH76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

69014:TK RS09515
gene id: 69014:TK_RS09515
uniprot id: Q5JET2
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

69014:TK RS04760
gene id: 69014:TK_RS04760
uniprot id: Q5JIB6
names: Similarity
messages: Belongs to the peptidase M24B family.

69014:TK RS02595
gene id: 69014:TK_RS02595
uniprot id: Q5JF10
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

69014:TK RS01360
gene id: 69014:TK_RS01360
uniprot id: Q5JFW0
names: Similarity
messages: Belongs to the RimK family. LysX subfamily.

69014:TK RS09920
gene id: 69014:TK_RS09920
uniprot id: Q5JIK2
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

69014:TK RS11190
gene id: 69014:TK_RS11190
uniprot id: Q5JHN3
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the FAU-1 family.
messages: Deletion mutant shows a delay of exponential phase, reduction of maximum cell number and significant changes in the nucleotide sequence lengths of its 5S, 16S, and 23S rRNAs in early exponential phase.
messages: Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Preferentially cleaves UA sequences in the 5' precursor region of 5S rRNA (PubMed:28978920). Binds to RNA in loop regions with AU-rich sequences (By similarity).

69014:TK RS09995
gene id: 69014:TK_RS09995
uniprot id: Q5JII7
names: Similarity
messages: Belongs to the HypE family.

69014:TK RS07460
gene id: 69014:TK_RS07460
uniprot id: Q5JJD2
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

69014:TK RS06635
gene id: 69014:TK_RS06635
uniprot id: Q5JGV2
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS10745
gene id: 69014:TK_RS10745
uniprot id: Q9HHC4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Can also use NAD, but less efficiently than ATP.
messages: Monomer.

69014:TK RS10640
gene id: 69014:TK_RS10640
uniprot id: Q5JEW7
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.

69014:TK RS05645
gene id: 69014:TK_RS05645
uniprot id: Q5JIG8
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS11355
gene id: 69014:TK_RS11355
uniprot id: Q5JHS0
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

69014:TK RS11940
gene id: 69014:TK_RS11940
uniprot id: Q9UWR7
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

69014:TK RS00730
gene id: 69014:TK_RS00730
uniprot id: Q5JFI4
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

69014:TK RS11585
gene id: 69014:TK_RS11585
uniprot id: Q5JDB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

69014:TK RS01045
gene id: 69014:TK_RS01045
uniprot id: Q5JFP8
names: Similarity
messages: Belongs to the UPF0175 family.

69014:TK RS07645
gene id: 69014:TK_RS07645
uniprot id: Q5JJF8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

69014:TK RS01505
gene id: 69014:TK_RS01505
uniprot id: Q5JFZ6
names: Similarity
messages: Belongs to the DEAD box helicase family.

69014:TK RS11100
gene id: 69014:TK_RS11100
uniprot id: Q5JHL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

69014:TK RS03255
gene id: 69014:TK_RS03255
uniprot id: Q5JF68
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS02715
gene id: 69014:TK_RS02715
uniprot id: Q5JF48
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

69014:TK RS07185
gene id: 69014:TK_RS07185
uniprot id: Q5JH53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

69014:TK RS11330
gene id: 69014:TK_RS11330
uniprot id: Q5JHS5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

69014:TK RS06010
gene id: 69014:TK_RS06010
uniprot id: Q5JGH6
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS00020
gene id: 69014:TK_RS00020
uniprot id: Q5JEA5
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS01775
gene id: 69014:TK_RS01775
uniprot id: Q5JCY9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

69014:TK RS06115
gene id: 69014:TK_RS06115
uniprot id: Q5JGK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

69014:TK RS07145
gene id: 69014:TK_RS07145
uniprot id: Q5JDJ7
names: Domain
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 57 family.
messages: Catalyzes the formation of branch points in alpha-glucans by cleavage of an alpha-1,4 glycosidic bond and subsequent transfer of the cleaved-off oligosaccharide to a new alpha-1,6 position. The branch chain-length distribution of the reaction products shows degree of polymerization (DP) of 5 to 30, with two local maxima at DP 6 and DP 11. Exhibits an alpha-retaining catalytic mechanism. Does not display alpha-galactosidase or pullulanase activity, since melibiose and pullulan are not substrates. Is not able to catalyze the hydrolysis or transglycosylation of maltoheptaose, suggesting that the TK1436 protein contains neither alpha-amylase nor 4-alpha-glucanotransferase activity.
messages: Monomer.
messages: The C-terminus contains two copies of a helix-hairpin-helix (HhH) motif that are dispensable for activity and thermal stability.
messages: Up-regulated by maltodextrin.

69014:TK RS07005
gene id: 69014:TK_RS07005
uniprot id: Q5JH13
names: Cofactor
names: Similarity
messages: Belongs to the UPF0292 family.
messages: Binds two Mg(2+) per subunit.

69014:TK RS11525
gene id: 69014:TK_RS11525
uniprot id: Q5JDC4
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

69014:TK RS10565
gene id: 69014:TK_RS10565
uniprot id: Q5JEV4
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS00060
gene id: 69014:TK_RS00060
uniprot id: Q5JEC0
names: Similarity
messages: Belongs to the UPF0047 family.

69014:TK RS07615
gene id: 69014:TK_RS07615
uniprot id: Q5JJG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

69014:TK RS05510
gene id: 69014:TK_RS05510
uniprot id: Q5JE64
names: Similarity
messages: Belongs to the UPF0127 family.

69014:TK RS10695
gene id: 69014:TK_RS10695
uniprot id: Q5JHG1
names: Similarity
messages: Belongs to the UPF0147 family.

69014:TK RS06035
gene id: 69014:TK_RS06035
uniprot id: Q5JGI9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

69014:TK RS08920
gene id: 69014:TK_RS08920
uniprot id: Q5JJ64
names: Similarity
messages: Belongs to the serpin family.

69014:TK RS09565
gene id: 69014:TK_RS09565
uniprot id: Q5JES4
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS09000
gene id: 69014:TK_RS09000
uniprot id: Q5JJ65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

69014:TK RS08445
gene id: 69014:TK_RS08445
uniprot id: Q5JIZ3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Grows at 85 degrees Celsius with a slightly longer lag phase, but is unable to grow at 93 degrees Celsius.
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine. Can also use spermine to produce N(4)-aminopropylspermine.

69014:TK RS07225
gene id: 69014:TK_RS07225
uniprot id: Q5JH45
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS10800
gene id: 69014:TK_RS10800
uniprot id: Q5JHH3
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS06985
gene id: 69014:TK_RS06985
uniprot id: Q5JH17
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS04710
gene id: 69014:TK_RS04710
uniprot id: Q5JIC6
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS09385
gene id: 69014:TK_RS09385
uniprot id: Q5JEP2
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

69014:TK RS03225
gene id: 69014:TK_RS03225
uniprot id: Q5JF74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

69014:TK RS01630
gene id: 69014:TK_RS01630
uniprot id: Q5JG02
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

69014:TK RS09885
gene id: 69014:TK_RS09885
uniprot id: O74023
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

69014:TK RS07855
gene id: 69014:TK_RS07855
uniprot id: Q5JIP3
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

69014:TK RS07045
gene id: 69014:TK_RS07045
uniprot id: Q5JH34
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

69014:TK RS08460
gene id: 69014:TK_RS08460
uniprot id: Q977X3
names: Cofactor
names: Function
messages: Binds 1 [4Fe-4S] cluster which readily converts to a stable [3Fe-4S] form.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

69014:TK RS03080
gene id: 69014:TK_RS03080
uniprot id: Q5JDL9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

69014:TK RS06555
gene id: 69014:TK_RS06555
uniprot id: Q5JGT4
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

69014:TK RS06570
gene id: 69014:TK_RS06570
uniprot id: Q5JGT1
names: Subcellular Location Annotation
messages: Cell membrane

69014:TK RS06045
gene id: 69014:TK_RS06045
uniprot id: Q5JGI7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

69014:TK RS05615
gene id: 69014:TK_RS05615
uniprot id: Q5JE76
names: Similarity
messages: Belongs to the AAA ATPase family.

69014:TK RS08865
gene id: 69014:TK_RS08865
uniprot id: Q5JJ58
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

69014:TK RS11280
gene id: 69014:TK_RS11280
uniprot id: Q5JHQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

69014:TK RS05430
gene id: 69014:TK_RS05430
uniprot id: Q5JE44
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS11035
gene id: 69014:TK_RS11035
uniprot id: Q5JHM9
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

69014:TK RS04160
gene id: 69014:TK_RS04160
uniprot id: Q5JDE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

69014:TK RS10200
gene id: 69014:TK_RS10200
uniprot id: Q5JDG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

69014:TK RS00095
gene id: 69014:TK_RS00095
uniprot id: Q5JEB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Probably responsible for the translocation of the substrate across the membrane (By similarity).
messages: The complex is composed of two ATP-binding proteins (WtpC), two transmembrane proteins (WtpB) and a solute-binding protein (WtpA).

69014:TK RS11120
gene id: 69014:TK_RS11120
uniprot id: Q5JHP7
names: Similarity
messages: Belongs to the HerA family.

69014:TK RS08590
gene id: 69014:TK_RS08590
uniprot id: Q5JJ26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

69014:TK RS07950
gene id: 69014:TK_RS07950
uniprot id: Q5JDS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

69014:TK RS08890
gene id: 69014:TK_RS08890
uniprot id: Q5JJ53
names: Similarity
messages: Belongs to the UPF0146 family.

69014:TK RS01340
gene id: 69014:TK_RS01340
uniprot id: Q5JFW4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family. LysK subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
messages: Cytoplasm

69014:TK RS10785
gene id: 69014:TK_RS10785
uniprot id: Q5JHH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

69014:TK RS04050
gene id: 69014:TK_RS04050
uniprot id: Q5JHZ2
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

69014:TK RS04525
gene id: 69014:TK_RS04525
uniprot id: Q5JI68
names: Similarity
messages: Belongs to the UPF0175 family.

69014:TK RS04780
gene id: 69014:TK_RS04780
uniprot id: Q5JIB2
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS09945
gene id: 69014:TK_RS09945
uniprot id: Q5JIJ7
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

69014:TK RS07575
gene id: 69014:TK_RS07575
uniprot id: Q5JJH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

69014:TK RS08085
gene id: 69014:TK_RS08085
uniprot id: Q5JIT1
names: Similarity
messages: Belongs to the MCM family.

69014:TK RS09020
gene id: 69014:TK_RS09020
uniprot id: Q5JJ94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

69014:TK RS10170
gene id: 69014:TK_RS10170
uniprot id: Q5JDG9
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Can use Mg(2+) and Ca(2+) with equal efficiency in vitro, and to a lesser extent, Co(2+).
messages: Disruption of the gene abolishes the generation of ribose 1,5-bisphosphate.
messages: Involved in nucleoside degradation. Phosphorylates ribose 1-phosphate (R1P) to ribose 1,5-bisphosphate. Can also act on deoxyribose 1-phosphate (dR1P), but is most active with R1P. ADP is the most preferred phosphate donor, followed by GDP and UDP.

69014:TK RS02205
gene id: 69014:TK_RS02205
uniprot id: Q5JD42
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

69014:TK RS11635
gene id: 69014:TK_RS11635
uniprot id: Q5JEZ9
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS11685
gene id: 69014:TK_RS11685
uniprot id: Q5JEQ9
names: Similarity
messages: Belongs to the UPF0252 family.

69014:TK RS02110
gene id: 69014:TK_RS02110
uniprot id: Q5JD32
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the N-terminal section; belongs to the DHBP synthase family.

69014:TK RS04565
gene id: 69014:TK_RS04565
uniprot id: Q5JI92
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.

69014:TK RS03220
gene id: 69014:TK_RS03220
uniprot id: Q5JF75
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS11600
gene id: 69014:TK_RS11600
uniprot id: Q52500
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Forms a Heterooligomeric complex of two stacked eight-membered rings.
messages: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

69014:TK RS02345
gene id: 69014:TK_RS02345
uniprot id: Q5JD63
names: Similarity
messages: Belongs to the HPS/KGPDC family. HPS subfamily.
messages: Belongs to the SIS family. PHI subfamily.

69014:TK RS00690
gene id: 69014:TK_RS00690
uniprot id: Q5JFH5
names: Similarity
messages: Belongs to the UPF0173 family.

69014:TK RS09380
gene id: 69014:TK_RS09380
uniprot id: Q5JEP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

69014:TK RS02635
gene id: 69014:TK_RS02635
uniprot id: Q5JF32
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer (PubMed:27141962). The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA (By similarity). Interacts with TIP (PubMed:24728986, PubMed:27141962).
messages: Inhibited by interaction with the PCNA inhibitor TIP.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

69014:TK RS11210
gene id: 69014:TK_RS11210
uniprot id: P95547
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange (By similarity).

69014:TK RS09550
gene id: 69014:TK_RS09550
uniprot id: Q5JES6
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

69014:TK RS07595
gene id: 69014:TK_RS07595
uniprot id: Q5JJG8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

69014:TK RS10750
gene id: 69014:TK_RS10750
uniprot id: Q5JHF1
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Homodimer.
messages: Moderately stimulated in the presence of potassium cations. Inhibited by increasing concentrations of pantoate. Activity is not affected by CoA/acetyl-CoA.
messages: Only viable in the presence of CoA or 4'-phosphopantothenate.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway (PubMed:19666462, PubMed:22865846). Displays broad nucleotide specificity and utilizes ATP, GTP, UTP, and CTP with comparable catalytic efficiencies (PubMed:22865846).

69014:TK RS09040
gene id: 69014:TK_RS09040
uniprot id: Q5JJ90
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

69014:TK RS03925
gene id: 69014:TK_RS03925
uniprot id: Q5JH75
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

69014:TK RS06410
gene id: 69014:TK_RS06410
uniprot id: Q5JGQ1
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

69014:TK RS04000
gene id: 69014:TK_RS04000
uniprot id: Q5JH72
names: Function
names: Subunit
messages: Binds to the DNA polymerase sliding clamp (PCNA) and dissociates the PCNA trimeric ring, leading to the inhibition of PCNA-dependent activities (PubMed:24728986, PubMed:27141962). In vitro, inhibits the PCNA-dependent activities of DNA polymerase PolB and of flap endonuclease 1 (FEN-1) (PubMed:24728986).
messages: Interacts with PCNA via a non-canonical PIP (PCNA-interacting peptide) motif. Can bind both Pcn1 and Pcn2.

69014:TK RS06245
gene id: 69014:TK_RS06245
uniprot id: Q8NKS6
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP inhibits the peptide cleavage activity of LonTk, but the enzyme retains 57% activity in comparison to the condition with the addition of ATP.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity (By similarity).
messages: Mg(2+). Exhibits no peptide cleavage activity without Mg(2+), regardless of the presence or the absence of ATP. Can also use other divalent cations such as Ni(2+), Ca(2+), Mn(2+) and Co(2+).
messages: Possesses a two-domain structure consisting of an N-terminal ATPase domain belonging to the AAA(+) superfamily and a C-terminal protease domain. The ATPase domain likely acts as a molecular chaperone functioning in the unfolding of protein structures, along with ATP hydrolysis.
messages: Serine protease that displays ATP-independent proteolytic activity towards peptides and unfolded proteins and ATP-dependent activity for the cleavage of folded proteins.

69014:TK RS00965
gene id: 69014:TK_RS00965
uniprot id: Q5JFL8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

69014:TK RS00670
gene id: 69014:TK_RS00670
uniprot id: O07835
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

69014:TK RS08795
gene id: 69014:TK_RS08795
uniprot id: Q5JDT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

69014:TK RS11270
gene id: 69014:TK_RS11270
uniprot id: Q5JHQ3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm

69014:TK RS05115
gene id: 69014:TK_RS05115
uniprot id: Q5JDW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclic 2,3-diphosphoglycerate synthetase family.
messages: Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP.
messages: Cytoplasm

69014:TK RS05610
gene id: 69014:TK_RS05610
uniprot id: Q5JE77
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS07360
gene id: 69014:TK_RS07360
uniprot id: Q5JJC1
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate.
messages: Cytoplasm
messages: Disruption of the gene results in a complete loss of ribose 1,5-bisphosphate generation from uridine.

69014:TK RS05450
gene id: 69014:TK_RS05450
uniprot id: Q5JE40
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

69014:TK RS09705
gene id: 69014:TK_RS09705
uniprot id: Q5JDP2
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS00995
gene id: 69014:TK_RS00995
uniprot id: Q5JFP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

69014:TK RS07820
gene id: 69014:TK_RS07820
uniprot id: Q5JIL7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

69014:TK RS08790
gene id: 69014:TK_RS08790
uniprot id: Q5JDU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

69014:TK RS11340
gene id: 69014:TK_RS11340
uniprot id: Q5JHS3
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS07675
gene id: 69014:TK_RS07675
uniprot id: Q5JDH4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

69014:TK RS09525
gene id: 69014:TK_RS09525
uniprot id: Q5JET0
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).
messages: This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.

69014:TK RS10460
gene id: 69014:TK_RS10460
uniprot id: Q5JHU9
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS02340
gene id: 69014:TK_RS02340
uniprot id: Q5JD64
names: Similarity
messages: Belongs to the arginase family.

69014:TK RS03425
gene id: 69014:TK_RS03425
uniprot id: Q5JG39
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS10675
gene id: 69014:TK_RS10675
uniprot id: Q5JHG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

69014:TK RS01660
gene id: 69014:TK_RS01660
uniprot id: Q5JG28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

69014:TK RS04800
gene id: 69014:TK_RS04800
uniprot id: Q5JIE1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.

69014:TK RS00350
gene id: 69014:TK_RS00350
uniprot id: Q5JEF6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

69014:TK RS00525
gene id: 69014:TK_RS00525
uniprot id: Q5JFE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

69014:TK RS02195
gene id: 69014:TK_RS02195
uniprot id: Q5JD44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

69014:TK RS08230
gene id: 69014:TK_RS08230
uniprot id: Q5JIT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

69014:TK RS08340
gene id: 69014:TK_RS08340
uniprot id: Q5JIY0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

69014:TK RS05295
gene id: 69014:TK_RS05295
uniprot id: Q5JE20
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

69014:TK RS01215
gene id: 69014:TK_RS01215
uniprot id: Q5JFU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

69014:TK RS03060
gene id: 69014:TK_RS03060
uniprot id: Q5JDM3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

69014:TK RS00255
gene id: 69014:TK_RS00255
uniprot id: Q5JEE3
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS08050
gene id: 69014:TK_RS08050
uniprot id: Q5JIQ2
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

69014:TK RS05210
gene id: 69014:TK_RS05210
uniprot id: Q5JDY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Dps family.
messages: Homododecamer. The 12 identical subunits form a hollow sphere into which the mineral iron core of up to 300 Fe(3+) can be deposited.
messages: Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction.
messages: nucleoid

69014:TK RS08155
gene id: 69014:TK_RS08155
uniprot id: Q5JIR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteromeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

69014:TK RS10440
gene id: 69014:TK_RS10440
uniprot id: Q5JHV3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

69014:TK RS06050
gene id: 69014:TK_RS06050
uniprot id: Q5JGI6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

69014:TK RS00910
gene id: 69014:TK_RS00910
uniprot id: Q5JFM9
names: Activity Regulation
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Only accepts the alpha-anomer of D-ribose 1,5-bisphosphate as substrate, being inactive on the beta-anomer. Displays a strict substrate specificity, since other phosphorylated sugars such as R5P, ribose, G16P, G6P, G1P, FBP, F6P, and PRPP, are not substrates. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Homohexamer; trimer of dimers.
messages: Is highly activated in the presence of AMP, with an increase of >40-fold in activity levels. Among other nucleotides, isomerase activity is slightly increased in the presence of GMP, but CMP, UMP, TMP, and NAD(+) have no effect; therefore, AMP is likely the major activator of R15P isomerase in vivo. To a lesser extent, various compounds with an adenosyl moiety, such as dAMP, adenosine, or methylthioadenosine, can also act as activators. The regulation of this enzyme by AMP prevents excess degradation of intracellular AMP by the archaeal AMP degradation pathway.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.
messages: Up-regulated by nucleosides (at protein level).

69014:TK RS01555
gene id: 69014:TK_RS01555
uniprot id: Q5JG00
names: Similarity
messages: Belongs to the UPF0248 family.

69014:TK RS00210
gene id: 69014:TK_RS00210
uniprot id: Q9V2W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

69014:TK RS07640
gene id: 69014:TK_RS07640
uniprot id: Q5JJF9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

69014:TK RS12145
gene id: 69014:TK_RS12145
uniprot id: Q5JFW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways.

69014:TK RS04455
gene id: 69014:TK_RS04455
uniprot id: Q5JI50
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

69014:TK RS00080
gene id: 69014:TK_RS00080
uniprot id: Q5JEB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.
messages: Cell membrane
messages: Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Binds tungstate and molybdate (By similarity).
messages: The complex is composed of two ATP-binding proteins (WtpC), two transmembrane proteins (WtpB) and a solute-binding protein (WtpA).

69014:TK RS02740
gene id: 69014:TK_RS02740
uniprot id: Q5JF43
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

69014:TK RS00860
gene id: 69014:TK_RS00860
uniprot id: Q5JFK6
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

69014:TK RS02545
gene id: 69014:TK_RS02545
uniprot id: Q5JF03
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

69014:TK RS01285
gene id: 69014:TK_RS01285
uniprot id: Q5JFT4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Reduced FMN (FMNH(2)).

69014:TK RS05885
gene id: 69014:TK_RS05885
uniprot id: Q5JGF0
names: Similarity
messages: Belongs to the UPF0212 family.

69014:TK RS00300
gene id: 69014:TK_RS00300
uniprot id: Q5JEG6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
messages: Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

69014:TK RS07565
gene id: 69014:TK_RS07565
uniprot id: Q5JJF7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

69014:TK RS09785
gene id: 69014:TK_RS09785
uniprot id: Q5JDM9
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

69014:TK RS08965
gene id: 69014:TK_RS08965
uniprot id: Q5JJ72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).

69014:TK RS09745
gene id: 69014:TK_RS09745
uniprot id: Q5JDL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

69014:TK RS07680
gene id: 69014:TK_RS07680
uniprot id: Q5JDH3
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

69014:TK RS11390
gene id: 69014:TK_RS11390
uniprot id: Q5JHU5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

69014:TK RS09915
gene id: 69014:TK_RS09915
uniprot id: Q5JIK3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

69014:TK RS04820
gene id: 69014:TK_RS04820
uniprot id: Q5JID7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

69014:TK RS01280
gene id: 69014:TK_RS01280
uniprot id: O93744
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Cytoplasm
messages: Homodimer.

69014:TK RS02760
gene id: 69014:TK_RS02760
uniprot id: Q5JF39
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes (By similarity). Incubation with DNA in vitro gives fibrous structures 10.3 +/- 1.1 nm in thickness (naked DNA is 1.83 +/- 0.37 nm). This protein does not significantly compact DNA (PubMed:21148291).
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

69014:TK RS04510
gene id: 69014:TK_RS04510
uniprot id: Q5JI71
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

69014:TK RS06970
gene id: 69014:TK_RS06970
uniprot id: Q68BJ5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

69014:TK RS04370
gene id: 69014:TK_RS04370
uniprot id: Q5JI34
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS05650
gene id: 69014:TK_RS05650
uniprot id: Q5JIG7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

69014:TK RS10425
gene id: 69014:TK_RS10425
uniprot id: Q5JHV6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

69014:TK RS01375
gene id: 69014:TK_RS01375
uniprot id: Q5JFV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

69014:TK RS01290
gene id: 69014:TK_RS01290
uniprot id: Q5JFT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

69014:TK RS05395
gene id: 69014:TK_RS05395
uniprot id: Q5JE51
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

69014:TK RS07825
gene id: 69014:TK_RS07825
uniprot id: Q5JIL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

69014:TK RS02600
gene id: 69014:TK_RS02600
uniprot id: Q5JF09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the desulfoferrodoxin family.
messages: Homotetramer.
messages: Uses electrons from reduced NADP, by way of rubredoxin and an oxidoreductase, to catalyze the reduction of superoxide to hydrogen peroxide.

69014:TK RS06095
gene id: 69014:TK_RS06095
uniprot id: Q5JGH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

69014:TK RS02485
gene id: 69014:TK_RS02485
uniprot id: Q5JD99
names: Similarity
messages: Belongs to the peptidase U62 family.

69014:TK RS07335
gene id: 69014:TK_RS07335
uniprot id: Q5JJC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

69014:TK RS06155
gene id: 69014:TK_RS06155
uniprot id: Q5JGJ8
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS07795
gene id: 69014:TK_RS07795
uniprot id: Q5JIM3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

69014:TK RS04520
gene id: 69014:TK_RS04520
uniprot id: Q5JI69
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit (By similarity). Zn(2+) can be replaced by Cu(2+), Co(2+), Ca(2+) or Mn(2+) to some extent (PubMed:19307254).
messages: Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate. To a lesser extent, also catalyzes the oxidation of L-serine.
messages: Cytoplasm
messages: Docking studies suggest a mode of interaction of TDH with 2-amino-3-ketobutyrate CoA ligase (KBL), the subsequent enzyme in the pathway for conversion of threonine to glycine. TDH is known to form a stable functional complex with KBL, most probably to shield the unstable intermediate and permit its channelling between the active sites of both enzymes.
messages: Homotetramer.

69014:TK RS01005
gene id: 69014:TK_RS01005
uniprot id: Q5JFP1
names: Cofactor
names: Similarity
messages: Belongs to the GARS family.
messages: Binds 2 magnesium or manganese ions per subunit.

69014:TK RS01720
gene id: 69014:TK_RS01720
uniprot id: Q5JCX6
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

69014:TK RS11555
gene id: 69014:TK_RS11555
uniprot id: Q5JDC5
names: Similarity
messages: Belongs to the UPF0128 family.

69014:TK RS07055
gene id: 69014:TK_RS07055
uniprot id: Q5JH32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

69014:TK RS00740
gene id: 69014:TK_RS00740
uniprot id: Q5JFJ8
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS06330
gene id: 69014:TK_RS06330
uniprot id: Q5JGN1
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

69014:TK RS11345
gene id: 69014:TK_RS11345
uniprot id: Q5JHS2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

69014:TK RS06550
gene id: 69014:TK_RS06550
uniprot id: Q5JGT5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

69014:TK RS05345
gene id: 69014:TK_RS05345
uniprot id: Q5JE27
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

69014:TK RS10625
gene id: 69014:TK_RS10625
uniprot id: Q5JEX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

69014:TK RS04815
gene id: 69014:TK_RS04815
uniprot id: Q5JID8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm

69014:TK RS03350
gene id: 69014:TK_RS03350
uniprot id: P61111
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Forms a Heterooligomeric complex of two stacked eight-membered rings.
messages: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

69014:TK RS05995
gene id: 69014:TK_RS05995
uniprot id: Q5JGG2
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

69014:TK RS08480
gene id: 69014:TK_RS08480
uniprot id: Q5JIY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

69014:TK RS05305
gene id: 69014:TK_RS05305
uniprot id: Q5JE35
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

69014:TK RS01305
gene id: 69014:TK_RS01305
uniprot id: Q5JFV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

69014:TK RS11535
gene id: 69014:TK_RS11535
uniprot id: O93627
names: Cofactor
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA) (PubMed:9988755, PubMed:10512715). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase (PubMed:17303759).
messages: Cells lacking this gene show a slight decrease in growth as compared to the wild-type when they are grown in nutrient-rich medium.
messages: Homodecamer, consisting of five dimer units which form a ring-like pentagonal structure. This arrangement is essential for its high thermostability (PubMed:12070156). In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits (PubMed:9988755).
messages: Up-regulated by nucleosides (at protein level).

69014:TK RS06850
gene id: 69014:TK_RS06850
uniprot id: Q5JGX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

69014:TK RS11440
gene id: 69014:TK_RS11440
uniprot id: Q9HHC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

69014:TK RS01655
gene id: 69014:TK_RS01655
uniprot id: Q5JG29
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

69014:TK RS03965
gene id: 69014:TK_RS03965
uniprot id: Q5JH79
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

69014:TK RS03950
gene id: 69014:TK_RS03950
uniprot id: Q5JH82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

69014:TK RS00990
gene id: 69014:TK_RS00990
uniprot id: Q5JFP4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

69014:TK RS07590
gene id: 69014:TK_RS07590
uniprot id: Q5JJG9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

69014:TK RS08905
gene id: 69014:TK_RS08905
uniprot id: Q5JJ50
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS02570
gene id: 69014:TK_RS02570
uniprot id: Q5JF15
names: Similarity
messages: Belongs to the IMPACT family.

69014:TK RS06965
gene id: 69014:TK_RS06965
uniprot id: Q5JH21
names: Similarity
messages: Belongs to the thymidylate kinase family.

69014:TK RS10545
gene id: 69014:TK_RS10545
uniprot id: Q877I0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by citrate. Inhibited by NaBH(4). Activity is independent of divalent metal cations.
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Could be involved in pentose biosynthesis.
messages: Cytoplasm
messages: Homodimer.

69014:TK RS09105
gene id: 69014:TK_RS09105
uniprot id: Q5JDW0
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS05855
gene id: 69014:TK_RS05855
uniprot id: Q5JGF6
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

69014:TK RS05300
gene id: 69014:TK_RS05300
uniprot id: Q5JE36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

69014:TK RS03955
gene id: 69014:TK_RS03955
uniprot id: Q5JH81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

69014:TK RS10895
gene id: 69014:TK_RS10895
uniprot id: Q5JHI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

69014:TK RS08560
gene id: 69014:TK_RS08560
uniprot id: Q5JJ01
names: Subcellular Location Annotation
messages: Membrane

69014:TK RS11320
gene id: 69014:TK_RS11320
uniprot id: Q5JHS7
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

69014:TK RS01245
gene id: 69014:TK_RS01245
uniprot id: Q9YGB4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

69014:TK RS07720
gene id: 69014:TK_RS07720
uniprot id: Q5JDI6
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

69014:TK RS02525
gene id: 69014:TK_RS02525
uniprot id: Q5JD88
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

69014:TK RS09340
gene id: 69014:TK_RS09340
uniprot id: Q5JEQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

69014:TK RS01065
gene id: 69014:TK_RS01065
uniprot id: Q5JFR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

69014:TK RS07955
gene id: 69014:TK_RS07955
uniprot id: Q5JDS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

69014:TK RS11180
gene id: 69014:TK_RS11180
uniprot id: Q5JHN5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.

69014:TK RS02430
gene id: 69014:TK_RS02430
uniprot id: Q52428
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp). Is specific for tRNA(Asp) since it aspartylates tRNA(Asn) 3 orders of magnitude less efficiently than tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.

69014:TK RS02190
gene id: 69014:TK_RS02190
uniprot id: Q5JD45
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

69014:TK RS05505
gene id: 69014:TK_RS05505
uniprot id: Q5JE65
names: Cofactor
messages: Binds 1 zinc ion per subunit.

69014:TK RS01270
gene id: 69014:TK_RS01270
uniprot id: Q9YGA9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

69014:TK RS08775
gene id: 69014:TK_RS08775
uniprot id: Q5JDU3
names: Function
names: Induction
names: Subunit
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. Involved in chitin degradation.
messages: Expression is induced by diacetylchitobiose (GlcNAc2) but not by chitobiose or maltose.
messages: Homodimer.