686340:METAL RS03420
gene id: 686340:METAL_RS03420
uniprot id: H8GQ77
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

686340:METAL RS02480
gene id: 686340:METAL_RS02480
uniprot id: H8GNC7
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

686340:METAL RS01245
gene id: 686340:METAL_RS01245
uniprot id: H8GLB8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase E/G family. RNase E subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per homotetramer.
messages: Cell inner membrane
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation. Within the RNA degradosome, RNase E assembles into a homotetramer formed by a dimer of dimers.
messages: Cytoplasm
messages: Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs.

686340:METAL RS03575
gene id: 686340:METAL_RS03575
uniprot id: H8GQA2
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

686340:METAL RS14350
gene id: 686340:METAL_RS14350
uniprot id: H8GMC4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

686340:METAL RS09465
gene id: 686340:METAL_RS09465
uniprot id: H8GPT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

686340:METAL RS05945
gene id: 686340:METAL_RS05945
uniprot id: H8GIJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

686340:METAL RS08130
gene id: 686340:METAL_RS08130
uniprot id: H8GM82
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

686340:METAL RS15090
gene id: 686340:METAL_RS15090
uniprot id: H8GNN4
names: Function
names: Similarity
messages: Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process.
messages: Belongs to the Nudix hydrolase family. NudF subfamily.

686340:METAL RS03670
gene id: 686340:METAL_RS03670
uniprot id: H8GQC1
names: Similarity
messages: Belongs to the ClpA/ClpB family.

686340:METAL RS05320
gene id: 686340:METAL_RS05320
uniprot id: H8GHA9
names: Similarity
messages: Belongs to the LOG family.

686340:METAL RS18060
gene id: 686340:METAL_RS18060
uniprot id: H8GHP7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

686340:METAL RS05800
gene id: 686340:METAL_RS05800
uniprot id: H8GI05
names: Function
names: Similarity
messages: Belongs to the nucleoside phosphorylase PpnP family.
messages: Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.

686340:METAL RS04750
gene id: 686340:METAL_RS04750
uniprot id: H8GGJ3
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

686340:METAL RS11260
gene id: 686340:METAL_RS11260
uniprot id: H8GGU4
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS10050
gene id: 686340:METAL_RS10050
uniprot id: H8GQK0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: In the N-terminal section; belongs to the FGAMS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

686340:METAL RS03780
gene id: 686340:METAL_RS03780
uniprot id: H8GQE3
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

686340:METAL RS20830
gene id: 686340:METAL_RS20830
uniprot id: H8GGW3
names: Similarity
messages: Belongs to the RelE toxin family.

686340:METAL RS18395
gene id: 686340:METAL_RS18395
uniprot id: H8GIC2
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

686340:METAL RS11675
gene id: 686340:METAL_RS11675
uniprot id: H8GHI1
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

686340:METAL RS13280
gene id: 686340:METAL_RS13280
uniprot id: H8GKF3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M15D family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.

686340:METAL RS21165
gene id: 686340:METAL_RS21165
uniprot id: H8GQ37
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

686340:METAL RS14220
gene id: 686340:METAL_RS14220
uniprot id: H8GM98
names: Similarity
messages: Belongs to the DapB family.

686340:METAL RS11740
gene id: 686340:METAL_RS11740
uniprot id: H8GHJ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

686340:METAL RS03040
gene id: 686340:METAL_RS03040
uniprot id: H8GPK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

686340:METAL RS06915
gene id: 686340:METAL_RS06915
uniprot id: H8GK82
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

686340:METAL RS17905
gene id: 686340:METAL_RS17905
uniprot id: H8GHL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

686340:METAL RS15905
gene id: 686340:METAL_RS15905
uniprot id: H8GQ09
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS04895
gene id: 686340:METAL_RS04895
uniprot id: H8GGM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

686340:METAL RS13860
gene id: 686340:METAL_RS13860
uniprot id: H8GLM6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family.
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Monomer.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

686340:METAL RS02690
gene id: 686340:METAL_RS02690
uniprot id: H8GNX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreD family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

686340:METAL RS01105
gene id: 686340:METAL_RS01105
uniprot id: H8GL90
names: Similarity
messages: Belongs to the UPF0166 family.

686340:METAL RS18285
gene id: 686340:METAL_RS18285
uniprot id: H8GI99
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

686340:METAL RS02530
gene id: 686340:METAL_RS02530
uniprot id: H8GND7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

686340:METAL RS08820
gene id: 686340:METAL_RS08820
uniprot id: H8GNJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell inner membrane
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

686340:METAL RS01875
gene id: 686340:METAL_RS01875
uniprot id: H8GMJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

686340:METAL RS15840
gene id: 686340:METAL_RS15840
uniprot id: H8GPJ1
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

686340:METAL RS18350
gene id: 686340:METAL_RS18350
uniprot id: H8GIB2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

686340:METAL RS05000
gene id: 686340:METAL_RS05000
uniprot id: H8GGP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmD/CycX/HelD family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

686340:METAL RS08680
gene id: 686340:METAL_RS08680
uniprot id: H8GNG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space.
messages: In the C-terminal section; belongs to the glycosyl hydrolase 73 family.
messages: In the N-terminal section; belongs to the FlgJ family.
messages: Periplasm

686340:METAL RS09515
gene id: 686340:METAL_RS09515
uniprot id: H8GPU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

686340:METAL RS04395
gene id: 686340:METAL_RS04395
uniprot id: H8GFW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility.
messages: Bacterial flagellum basal body
messages: Belongs to the YcgR family.
messages: Monomer. Interacts with the flagellar basal bodies.

686340:METAL RS01305
gene id: 686340:METAL_RS01305
uniprot id: H8GLD0
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

686340:METAL RS11030
gene id: 686340:METAL_RS11030
uniprot id: H8GGP9
names: Similarity
names: Subunit
messages: Belongs to the Ahb/Nir family.
messages: Probably forms a complex composed of NirD, NirL, NirG and NirH. All proteins are required for the total conversion of siroheme to didecarboxysiroheme.

686340:METAL RS09285
gene id: 686340:METAL_RS09285
uniprot id: H8GP94
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS08550
gene id: 686340:METAL_RS08550
uniprot id: H8GMX6
names: Function
messages: Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.

686340:METAL RS02020
gene id: 686340:METAL_RS02020
uniprot id: H8GMM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT).
messages: Cytoplasm
messages: Homotetramer.

686340:METAL RS09360
gene id: 686340:METAL_RS09360
uniprot id: H8GPA9
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

686340:METAL RS11665
gene id: 686340:METAL_RS11665
uniprot id: H8GHH9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS00410
gene id: 686340:METAL_RS00410
uniprot id: H8GJZ6
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS12775
gene id: 686340:METAL_RS12775
uniprot id: H8GJJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

686340:METAL RS03770
gene id: 686340:METAL_RS03770
uniprot id: H8GQE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RlpA family.
messages: Cell membrane
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

686340:METAL RS16275
gene id: 686340:METAL_RS16275
uniprot id: H8GQN6
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Comprises two domains: an N-terminal domain containing the nucleotidyltransferase activity and a C-terminal HD domain associated with both phosphodiesterase and phosphatase activities.
messages: Magnesium is required for nucleotidyltransferase activity.
messages: Monomer. Can also form homodimers and oligomers.
messages: Nickel for phosphatase activity.

686340:METAL RS18855
gene id: 686340:METAL_RS18855
uniprot id: H8GJ15
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

686340:METAL RS06795
gene id: 686340:METAL_RS06795
uniprot id: H8GK59
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxH family.
messages: Binds 2 Mn(2+) ions per subunit in a binuclear metal center.
messages: Cell inner membrane
messages: Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

686340:METAL RS18500
gene id: 686340:METAL_RS18500
uniprot id: H8GIE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

686340:METAL RS14240
gene id: 686340:METAL_RS14240
uniprot id: H8GMA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

686340:METAL RS06855
gene id: 686340:METAL_RS06855
uniprot id: H8GK70
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48 family. BepA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state.
messages: Periplasm

686340:METAL RS18620
gene id: 686340:METAL_RS18620
uniprot id: H8GIG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

686340:METAL RS16310
gene id: 686340:METAL_RS16310
uniprot id: H8GQP1
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

686340:METAL RS04985
gene id: 686340:METAL_RS04985
uniprot id: H8GGP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

686340:METAL RS16285
gene id: 686340:METAL_RS16285
uniprot id: H8GQN8
names: Similarity
messages: Belongs to the UPF0234 family.

686340:METAL RS09655
gene id: 686340:METAL_RS09655
uniprot id: H8GPX6
names: Similarity
messages: Belongs to the GppA/Ppx family.

686340:METAL RS03785
gene id: 686340:METAL_RS03785
uniprot id: H8GQE4
names: Similarity
messages: Belongs to the UPF0250 family.

686340:METAL RS05540
gene id: 686340:METAL_RS05540
uniprot id: H8GHW0
names: Similarity
messages: Belongs to the TrpF family.

686340:METAL RS04315
gene id: 686340:METAL_RS04315
uniprot id: H8GFV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
messages: Cell inner membrane

686340:METAL RS13610
gene id: 686340:METAL_RS13610
uniprot id: H8GL25
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

686340:METAL RS05985
gene id: 686340:METAL_RS05985
uniprot id: H8GIJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

686340:METAL RS18745
gene id: 686340:METAL_RS18745
uniprot id: H8GIZ5
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

686340:METAL RS04880
gene id: 686340:METAL_RS04880
uniprot id: H8GGL9
names: Similarity
messages: Belongs to the SAICAR synthetase family.

686340:METAL RS09050
gene id: 686340:METAL_RS09050
uniprot id: H8GP44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

686340:METAL RS04175
gene id: 686340:METAL_RS04175
uniprot id: H8GR21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

686340:METAL RS15735
gene id: 686340:METAL_RS15735
uniprot id: H8GPH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

686340:METAL RS17450
gene id: 686340:METAL_RS17450
uniprot id: H8GGG4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS07960
gene id: 686340:METAL_RS07960
uniprot id: H8GM54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

686340:METAL RS16980
gene id: 686340:METAL_RS16980
uniprot id: H8GRH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

686340:METAL RS14785
gene id: 686340:METAL_RS14785
uniprot id: H8GN20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

686340:METAL RS12085
gene id: 686340:METAL_RS12085
uniprot id: H8GI67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.

686340:METAL RS11350
gene id: 686340:METAL_RS11350
uniprot id: H8GGW1
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

686340:METAL RS19005
gene id: 686340:METAL_RS19005
uniprot id: H8GJ45
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS09335
gene id: 686340:METAL_RS09335
uniprot id: H8GPA4
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS05795
gene id: 686340:METAL_RS05795
uniprot id: H8GI04
names: Similarity
messages: Belongs to the UPF0260 family.

686340:METAL RS09945
gene id: 686340:METAL_RS09945
uniprot id: H8GQI0
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

686340:METAL RS05505
gene id: 686340:METAL_RS05505
uniprot id: H8GHV3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS12145
gene id: 686340:METAL_RS12145
uniprot id: H8GI78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZapD family.
messages: Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
messages: Cytoplasm
messages: Interacts with FtsZ.

686340:METAL RS06475
gene id: 686340:METAL_RS06475
uniprot id: H8GJD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

686340:METAL RS12155
gene id: 686340:METAL_RS12155
uniprot id: H8GI80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.

686340:METAL RS04815
gene id: 686340:METAL_RS04815
uniprot id: H8GGK6
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

686340:METAL RS15430
gene id: 686340:METAL_RS15430
uniprot id: H8GNU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

686340:METAL RS16010
gene id: 686340:METAL_RS16010
uniprot id: H8GQ31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

686340:METAL RS05810
gene id: 686340:METAL_RS05810
uniprot id: H8GI07
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

686340:METAL RS17655
gene id: 686340:METAL_RS17655
uniprot id: H8GH08
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS01140
gene id: 686340:METAL_RS01140
uniprot id: H8GL97
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

686340:METAL RS03605
gene id: 686340:METAL_RS03605
uniprot id: H8GQA8
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

686340:METAL RS17490
gene id: 686340:METAL_RS17490
uniprot id: H8GGX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

686340:METAL RS00225
gene id: 686340:METAL_RS00225
uniprot id: H8GJV8
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS18300
gene id: 686340:METAL_RS18300
uniprot id: H8GIA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

686340:METAL RS16325
gene id: 686340:METAL_RS16325
uniprot id: H8GQP4
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

686340:METAL RS14795
gene id: 686340:METAL_RS14795
uniprot id: H8GN22
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

686340:METAL RS04320
gene id: 686340:METAL_RS04320
uniprot id: H8GFV2
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

686340:METAL RS16185
gene id: 686340:METAL_RS16185
uniprot id: H8GQ62
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

686340:METAL RS16625
gene id: 686340:METAL_RS16625
uniprot id: H8GQU7
names: Similarity
messages: Belongs to the TPP enzyme family.

686340:METAL RS00350
gene id: 686340:METAL_RS00350
uniprot id: H8GJY3
names: Similarity
messages: Belongs to the ArsC family.

686340:METAL RS14245
gene id: 686340:METAL_RS14245
uniprot id: H8GMA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

686340:METAL RS16025
gene id: 686340:METAL_RS16025
uniprot id: H8GQ34
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

686340:METAL RS05075
gene id: 686340:METAL_RS05075
uniprot id: H8GH62
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

686340:METAL RS06520
gene id: 686340:METAL_RS06520
uniprot id: H8GJE3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

686340:METAL RS18170
gene id: 686340:METAL_RS18170
uniprot id: H8GHR9
names: Similarity
messages: Belongs to the GbsR family.

686340:METAL RS18070
gene id: 686340:METAL_RS18070
uniprot id: H8GHP9
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

686340:METAL RS00715
gene id: 686340:METAL_RS00715
uniprot id: H8GKK6
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

686340:METAL RS02275
gene id: 686340:METAL_RS02275
uniprot id: H8GKC5
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

686340:METAL RS15560
gene id: 686340:METAL_RS15560
uniprot id: H8GPD4
names: Function
names: Similarity
messages: Belongs to the esterase D family.
messages: Serine hydrolase involved in the detoxification of formaldehyde.

686340:METAL RS01055
gene id: 686340:METAL_RS01055
uniprot id: H8GL82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

686340:METAL RS18880
gene id: 686340:METAL_RS18880
uniprot id: H8GJ20
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

686340:METAL RS15930
gene id: 686340:METAL_RS15930
uniprot id: H8GQ14
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

686340:METAL RS19145
gene id: 686340:METAL_RS19145
uniprot id: H8GJP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

686340:METAL RS17640
gene id: 686340:METAL_RS17640
uniprot id: H8GH05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter family.
messages: Membrane

686340:METAL RS09525
gene id: 686340:METAL_RS09525
uniprot id: H8GPV0
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS13660
gene id: 686340:METAL_RS13660
uniprot id: H8GL35
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

686340:METAL RS05855
gene id: 686340:METAL_RS05855
uniprot id: H8GIH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0382 family.
messages: Membrane

686340:METAL RS01485
gene id: 686340:METAL_RS01485
uniprot id: H8GLW9
names: Cofactor
messages: Binds 1 heme c group covalently per subunit.

686340:METAL RS11045
gene id: 686340:METAL_RS11045
uniprot id: H8GGQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

686340:METAL RS08475
gene id: 686340:METAL_RS08475
uniprot id: H8GMW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

686340:METAL RS09245
gene id: 686340:METAL_RS09245
uniprot id: H8GP86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioester dehydratase family. FabA subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.

686340:METAL RS03240
gene id: 686340:METAL_RS03240
uniprot id: H8GPP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Cytoplasm

686340:METAL RS08290
gene id: 686340:METAL_RS08290
uniprot id: H8GMS1
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

686340:METAL RS10300
gene id: 686340:METAL_RS10300
uniprot id: H8GR50
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

686340:METAL RS10185
gene id: 686340:METAL_RS10185
uniprot id: H8GR29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

686340:METAL RS01860
gene id: 686340:METAL_RS01860
uniprot id: H8GMJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

686340:METAL RS01240
gene id: 686340:METAL_RS01240
uniprot id: H8GLB7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

686340:METAL RS12440
gene id: 686340:METAL_RS12440
uniprot id: H8GIU0
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

686340:METAL RS03735
gene id: 686340:METAL_RS03735
uniprot id: H8GQD4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

686340:METAL RS16800
gene id: 686340:METAL_RS16800
uniprot id: H8GRD6
names: Cofactor
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Divalent metal ions. Mg(2+) is the most effective.

686340:METAL RS12920
gene id: 686340:METAL_RS12920
uniprot id: H8GJL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial glucokinase family.
messages: Cytoplasm

686340:METAL RS09670
gene id: 686340:METAL_RS09670
uniprot id: H8GPX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OadG family.
messages: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
messages: Cell membrane
messages: Heterotrimer of an alpha, a beta and a gamma subunit.
messages: Membrane

686340:METAL RS02370
gene id: 686340:METAL_RS02370
uniprot id: H8GNA5
names: Similarity
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.

686340:METAL RS06950
gene id: 686340:METAL_RS06950
uniprot id: H8GK89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsB family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

686340:METAL RS02720
gene id: 686340:METAL_RS02720
uniprot id: H8GNX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

686340:METAL RS04630
gene id: 686340:METAL_RS04630
uniprot id: H8GGH0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

686340:METAL RS07035
gene id: 686340:METAL_RS07035
uniprot id: H8GKQ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

686340:METAL RS16960
gene id: 686340:METAL_RS16960
uniprot id: H8GRG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

686340:METAL RS13385
gene id: 686340:METAL_RS13385
uniprot id: H8GKH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

686340:METAL RS18535
gene id: 686340:METAL_RS18535
uniprot id: H8GIE7
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

686340:METAL RS17795
gene id: 686340:METAL_RS17795
uniprot id: H8GH37
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

686340:METAL RS07505
gene id: 686340:METAL_RS07505
uniprot id: H8GLF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

686340:METAL RS08250
gene id: 686340:METAL_RS08250
uniprot id: H8GMR3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

686340:METAL RS09900
gene id: 686340:METAL_RS09900
uniprot id: H8GQH1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

686340:METAL RS18065
gene id: 686340:METAL_RS18065
uniprot id: H8GHP8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

686340:METAL RS05650
gene id: 686340:METAL_RS05650
uniprot id: H8GHX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

686340:METAL RS18995
gene id: 686340:METAL_RS18995
uniprot id: H8GJ43
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

686340:METAL RS04510
gene id: 686340:METAL_RS04510
uniprot id: H8GFZ2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

686340:METAL RS16195
gene id: 686340:METAL_RS16195
uniprot id: H8GQ64
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

686340:METAL RS09755
gene id: 686340:METAL_RS09755
uniprot id: H8GPZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Cell inner membrane
messages: Membrane

686340:METAL RS06930
gene id: 686340:METAL_RS06930
uniprot id: H8GK85
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.

686340:METAL RS19015
gene id: 686340:METAL_RS19015
uniprot id: H8GJ47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

686340:METAL RS14820
gene id: 686340:METAL_RS14820
uniprot id: H8GN27
names: Similarity
messages: Belongs to the ABC transporter superfamily.

686340:METAL RS07375
gene id: 686340:METAL_RS07375
uniprot id: H8GKX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: Composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

686340:METAL RS05970
gene id: 686340:METAL_RS05970
uniprot id: H8GIJ6
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

686340:METAL RS17390
gene id: 686340:METAL_RS17390
uniprot id: H8GGF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

686340:METAL RS14645
gene id: 686340:METAL_RS14645
uniprot id: H8GMZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

686340:METAL RS10200
gene id: 686340:METAL_RS10200
uniprot id: H8GR32
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

686340:METAL RS18710
gene id: 686340:METAL_RS18710
uniprot id: H8GIY9
names: Function
names: Subcellular Location Annotation
messages: Involved in mercury resistance. Acts as a mercury scavenger that specifically binds to a mercuric ion in the periplasm and probably passes it to the cytoplasmic mercuric reductase MerA via the mercuric transport protein MerT.
messages: Periplasm

686340:METAL RS10685
gene id: 686340:METAL_RS10685
uniprot id: H8GG24
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

686340:METAL RS10720
gene id: 686340:METAL_RS10720
uniprot id: H8GG32
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

686340:METAL RS00815
gene id: 686340:METAL_RS00815
uniprot id: H8GKM5
names: Similarity
messages: Belongs to the UPF0276 family.

686340:METAL RS06715
gene id: 686340:METAL_RS06715
uniprot id: H8GK42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane
messages: Membrane

686340:METAL RS07060
gene id: 686340:METAL_RS07060
uniprot id: H8GKR3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

686340:METAL RS12180
gene id: 686340:METAL_RS12180
uniprot id: H8GI84
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

686340:METAL RS16255
gene id: 686340:METAL_RS16255
uniprot id: H8GQN2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

686340:METAL RS15915
gene id: 686340:METAL_RS15915
uniprot id: H8GQ11
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

686340:METAL RS13855
gene id: 686340:METAL_RS13855
uniprot id: H8GLM5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

686340:METAL RS08530
gene id: 686340:METAL_RS08530
uniprot id: H8GMX1
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

686340:METAL RS16175
gene id: 686340:METAL_RS16175
uniprot id: H8GQ60
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolB family.
messages: Cell outer membrane
messages: Membrane
messages: Monomer.

686340:METAL RS13885
gene id: 686340:METAL_RS13885
uniprot id: H8GLN1
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

686340:METAL RS18225
gene id: 686340:METAL_RS18225
uniprot id: H8GHT1
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

686340:METAL RS17890
gene id: 686340:METAL_RS17890
uniprot id: H8GHL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RlmG family.
messages: Cytoplasm
messages: Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.

686340:METAL RS17785
gene id: 686340:METAL_RS17785
uniprot id: H8GH35
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS09250
gene id: 686340:METAL_RS09250
uniprot id: H8GP87
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

686340:METAL RS14115
gene id: 686340:METAL_RS14115
uniprot id: H8GLS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

686340:METAL RS12335
gene id: 686340:METAL_RS12335
uniprot id: H8GIS0
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.

686340:METAL RS15985
gene id: 686340:METAL_RS15985
uniprot id: H8GQ26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

686340:METAL RS00950
gene id: 686340:METAL_RS00950
uniprot id: H8GKQ2
names: Subcellular Location Annotation
messages: Cytoplasm

686340:METAL RS18095
gene id: 686340:METAL_RS18095
uniprot id: H8GHQ5
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.
messages: Belongs to the RecD family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

686340:METAL RS01970
gene id: 686340:METAL_RS01970
uniprot id: H8GML6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

686340:METAL RS17770
gene id: 686340:METAL_RS17770
uniprot id: H8GH32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

686340:METAL RS17680
gene id: 686340:METAL_RS17680
uniprot id: H8GH13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

686340:METAL RS04915
gene id: 686340:METAL_RS04915
uniprot id: H8GGM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Membrane

686340:METAL RS00625
gene id: 686340:METAL_RS00625
uniprot id: H8GKI9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

686340:METAL RS09590
gene id: 686340:METAL_RS09590
uniprot id: H8GPW4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

686340:METAL RS04090
gene id: 686340:METAL_RS04090
uniprot id: H8GR02
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MetA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.

686340:METAL RS08380
gene id: 686340:METAL_RS08380
uniprot id: H8GMU2
names: Similarity
messages: Belongs to the type III secretion exporter family.

686340:METAL RS09220
gene id: 686340:METAL_RS09220
uniprot id: H8GP81
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

686340:METAL RS17385
gene id: 686340:METAL_RS17385
uniprot id: H8GGF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

686340:METAL RS01420
gene id: 686340:METAL_RS01420
uniprot id: H8GLV7
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

686340:METAL RS00295
gene id: 686340:METAL_RS00295
uniprot id: H8GJX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

686340:METAL RS14395
gene id: 686340:METAL_RS14395
uniprot id: H8GMD2
names: Function
names: Similarity
messages: Belongs to the Ap4A hydrolase family.
messages: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.

686340:METAL RS04545
gene id: 686340:METAL_RS04545
uniprot id: H8GFZ9
names: Function
names: Similarity
messages: Belongs to the SsuD family.
messages: Catalyzes the desulfonation of aliphatic sulfonates.

686340:METAL RS13160
gene id: 686340:METAL_RS13160
uniprot id: H8GKD2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase S45 family.
messages: Binds 1 Ca(2+) ion per dimer.

686340:METAL RS11585
gene id: 686340:METAL_RS11585
uniprot id: H8GHG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RlmKL family.
messages: Cytoplasm
messages: Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.

686340:METAL RS08580
gene id: 686340:METAL_RS08580
uniprot id: H8GMY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliH family.
messages: Cytoplasm
messages: Needed for flagellar regrowth and assembly.

686340:METAL RS08610
gene id: 686340:METAL_RS08610
uniprot id: H8GNE7
names: Function
names: Similarity
messages: Belongs to the FlgN family.
messages: Required for the efficient initiation of filament assembly.

686340:METAL RS16305
gene id: 686340:METAL_RS16305
uniprot id: H8GQP0
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

686340:METAL RS01395
gene id: 686340:METAL_RS01395
uniprot id: H8GLV1
names: Similarity
messages: Belongs to the Gfa family.

686340:METAL RS18895
gene id: 686340:METAL_RS18895
uniprot id: H8GJ23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

686340:METAL RS11865
gene id: 686340:METAL_RS11865
uniprot id: H8GI25
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

686340:METAL RS07390
gene id: 686340:METAL_RS07390
uniprot id: H8GKX8
names: Similarity
names: Subunit
messages: Belongs to the complex I 75 kDa subunit family.
messages: Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex.

686340:METAL RS17760
gene id: 686340:METAL_RS17760
uniprot id: H8GH30
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

686340:METAL RS15120
gene id: 686340:METAL_RS15120
uniprot id: H8GNP1
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

686340:METAL RS09505
gene id: 686340:METAL_RS09505
uniprot id: H8GPU6
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS11495
gene id: 686340:METAL_RS11495
uniprot id: H8GHE4
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

686340:METAL RS05760
gene id: 686340:METAL_RS05760
uniprot id: H8GHZ7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

686340:METAL RS17790
gene id: 686340:METAL_RS17790
uniprot id: H8GH36
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

686340:METAL RS12880
gene id: 686340:METAL_RS12880
uniprot id: H8GJK8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

686340:METAL RS04830
gene id: 686340:METAL_RS04830
uniprot id: H8GGK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell membrane
messages: Membrane
messages: Transport of potassium into the cell. Likely operates as a K(+):H(+) symporter.

686340:METAL RS00220
gene id: 686340:METAL_RS00220
uniprot id: H8GJV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

686340:METAL RS05210
gene id: 686340:METAL_RS05210
uniprot id: H8GH88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

686340:METAL RS18490
gene id: 686340:METAL_RS18490
uniprot id: H8GID9
names: Similarity
messages: Belongs to the IMPACT family.

686340:METAL RS05250
gene id: 686340:METAL_RS05250
uniprot id: H8GH95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.
messages: Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine.
messages: Cytoplasm
messages: Homodimer.

686340:METAL RS17545
gene id: 686340:METAL_RS17545
uniprot id: H8GGY7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

686340:METAL RS04950
gene id: 686340:METAL_RS04950
uniprot id: H8GGN3
names: Similarity
messages: Belongs to the UPF0758 family.

686340:METAL RS00475
gene id: 686340:METAL_RS00475
uniprot id: H8GK10
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

686340:METAL RS18795
gene id: 686340:METAL_RS18795
uniprot id: H8GJ04
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

686340:METAL RS01360
gene id: 686340:METAL_RS01360
uniprot id: H8GLE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

686340:METAL RS08640
gene id: 686340:METAL_RS08640
uniprot id: H8GNF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

686340:METAL RS02190
gene id: 686340:METAL_RS02190
uniprot id: H8GN72
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS06890
gene id: 686340:METAL_RS06890
uniprot id: H8GK77
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

686340:METAL RS13790
gene id: 686340:METAL_RS13790
uniprot id: H8GL58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

686340:METAL RS11640
gene id: 686340:METAL_RS11640
uniprot id: H8GHH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

686340:METAL RS14560
gene id: 686340:METAL_RS14560
uniprot id: H8GMG4
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

686340:METAL RS07560
gene id: 686340:METAL_RS07560
uniprot id: H8GLG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

686340:METAL RS09485
gene id: 686340:METAL_RS09485
uniprot id: H8GPU1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

686340:METAL RS08470
gene id: 686340:METAL_RS08470
uniprot id: H8GMV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

686340:METAL RS05705
gene id: 686340:METAL_RS05705
uniprot id: H8GHY6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
messages: Cell membrane
messages: Heterodimer of a large and a small subunit.

686340:METAL RS14270
gene id: 686340:METAL_RS14270
uniprot id: H8GMA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

686340:METAL RS03725
gene id: 686340:METAL_RS03725
uniprot id: H8GQD2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

686340:METAL RS04810
gene id: 686340:METAL_RS04810
uniprot id: H8GGK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

686340:METAL RS16585
gene id: 686340:METAL_RS16585
uniprot id: H8GQT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

686340:METAL RS12955
gene id: 686340:METAL_RS12955
uniprot id: H8GKC5
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

686340:METAL RS07935
gene id: 686340:METAL_RS07935
uniprot id: H8GM49
names: Similarity
messages: Belongs to the type IA topoisomerase family.

686340:METAL RS09445
gene id: 686340:METAL_RS09445
uniprot id: H8GPT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane

686340:METAL RS03615
gene id: 686340:METAL_RS03615
uniprot id: H8GQB0
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS12905
gene id: 686340:METAL_RS12905
uniprot id: H8GJL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

686340:METAL RS01190
gene id: 686340:METAL_RS01190
uniprot id: H8GLA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptA family.
messages: Component of the lipopolysaccharide transport and assembly complex.
messages: Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.
messages: Periplasm

686340:METAL RS13165
gene id: 686340:METAL_RS13165
uniprot id: H8GKD3
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS01250
gene id: 686340:METAL_RS01250
uniprot id: H8GLB9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

686340:METAL RS00425
gene id: 686340:METAL_RS00425
uniprot id: H8GK00
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

686340:METAL RS10855
gene id: 686340:METAL_RS10855
uniprot id: H8GG58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

686340:METAL RS13800
gene id: 686340:METAL_RS13800
uniprot id: H8GL60
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

686340:METAL RS12275
gene id: 686340:METAL_RS12275
uniprot id: H8GIQ7
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the WrbA family.
messages: Binds 1 FMN per monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS18250
gene id: 686340:METAL_RS18250
uniprot id: H8GHT6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

686340:METAL RS06920
gene id: 686340:METAL_RS06920
uniprot id: H8GK83
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS04940
gene id: 686340:METAL_RS04940
uniprot id: H8GGN1
names: Caution
names: Function
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
messages: Catalyzes the biosynthesis of agmatine from arginine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS18280
gene id: 686340:METAL_RS18280
uniprot id: H8GI98
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

686340:METAL RS14435
gene id: 686340:METAL_RS14435
uniprot id: H8GME0
names: Similarity
messages: Belongs to the SlyX family.

686340:METAL RS05020
gene id: 686340:METAL_RS05020
uniprot id: H8GH52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
messages: Cell inner membrane
messages: Membrane

686340:METAL RS15175
gene id: 686340:METAL_RS15175
uniprot id: H8GNQ2
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS18885
gene id: 686340:METAL_RS18885
uniprot id: H8GJ21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane

686340:METAL RS06490
gene id: 686340:METAL_RS06490
uniprot id: H8GJD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

686340:METAL RS14585
gene id: 686340:METAL_RS14585
uniprot id: H8GMH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute-binding proteins (MlaB) and six periplasmic solute-binding proteins (MlaD).

686340:METAL RS18210
gene id: 686340:METAL_RS18210
uniprot id: H8GHS8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

686340:METAL RS09715
gene id: 686340:METAL_RS09715
uniprot id: H8GPY8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueG family.
messages: Binds 2 [4Fe-4S] clusters per monomer.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

686340:METAL RS15275
gene id: 686340:METAL_RS15275
uniprot id: H8GNR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoS subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.

686340:METAL RS08220
gene id: 686340:METAL_RS08220
uniprot id: H8GM97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

686340:METAL RS14095
gene id: 686340:METAL_RS14095
uniprot id: H8GLS0
names: Similarity
messages: Belongs to the UDPGP type 2 family.

686340:METAL RS05830
gene id: 686340:METAL_RS05830
uniprot id: H8GI11
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

686340:METAL RS14235
gene id: 686340:METAL_RS14235
uniprot id: H8GKC5
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

686340:METAL RS04460
gene id: 686340:METAL_RS04460
uniprot id: H8GFY2
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

686340:METAL RS08785
gene id: 686340:METAL_RS08785
uniprot id: H8GNI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX11/CtaG family.
messages: Cell inner membrane
messages: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.

686340:METAL RS06410
gene id: 686340:METAL_RS06410
uniprot id: H8GJC1
names: Similarity
messages: Belongs to the UPF0125 (RnfH) family.

686340:METAL RS10840
gene id: 686340:METAL_RS10840
uniprot id: H8GG55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

686340:METAL RS02705
gene id: 686340:METAL_RS02705
uniprot id: H8GNX6
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two nickel ions.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

686340:METAL RS08800
gene id: 686340:METAL_RS08800
uniprot id: H8GNI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Cell membrane

686340:METAL RS06280
gene id: 686340:METAL_RS06280
uniprot id: H8GJ96
names: Similarity
messages: Belongs to the NodU/CmcH family.

686340:METAL RS11625
gene id: 686340:METAL_RS11625
uniprot id: H8GHH1
names: Similarity
messages: Belongs to the DNA polymerase HolA subunit family.

686340:METAL RS07030
gene id: 686340:METAL_RS07030
uniprot id: H8GKQ7
names: Similarity
messages: Belongs to the peptidase U62 family.

686340:METAL RS15215
gene id: 686340:METAL_RS15215
uniprot id: H8GNQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

686340:METAL RS20280
gene id: 686340:METAL_RS20280
uniprot id: H8GL65
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-66 and Arg-69) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

686340:METAL RS08810
gene id: 686340:METAL_RS08810
uniprot id: H8GNI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

686340:METAL RS09645
gene id: 686340:METAL_RS09645
uniprot id: H8GPX4
names: Cofactor
names: PTM
names: Subcellular Location Annotation
messages: Binds 2 heme groups per subunit.
messages: Binds 2 heme groups.
messages: Periplasm

686340:METAL RS08515
gene id: 686340:METAL_RS08515
uniprot id: H8GMW8
names: Function
messages: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY.

686340:METAL RS09785
gene id: 686340:METAL_RS09785
uniprot id: H8GQF2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b560 family.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers.
messages: The heme is bound between the two transmembrane subunits.

686340:METAL RS17015
gene id: 686340:METAL_RS17015
uniprot id: H8GRH8
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS15635
gene id: 686340:METAL_RS15635
uniprot id: H8GPF0
names: Similarity
messages: Belongs to the HesB/IscA family.

686340:METAL RS18055
gene id: 686340:METAL_RS18055
uniprot id: H8GHP6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

686340:METAL RS01755
gene id: 686340:METAL_RS01755
uniprot id: H8GM20
names: Function
names: Similarity
messages: Belongs to the bacterioferritin family.
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

686340:METAL RS01385
gene id: 686340:METAL_RS01385
uniprot id: H8GLU9
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

686340:METAL RS17535
gene id: 686340:METAL_RS17535
uniprot id: H8GGY5
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS15810
gene id: 686340:METAL_RS15810
uniprot id: H8GPI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamD family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

686340:METAL RS06130
gene id: 686340:METAL_RS06130
uniprot id: H8GIM7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS16110
gene id: 686340:METAL_RS16110
uniprot id: H8GQ52
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

686340:METAL RS18075
gene id: 686340:METAL_RS18075
uniprot id: H8GHQ0
names: Function
names: Similarity
messages: Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

686340:METAL RS03635
gene id: 686340:METAL_RS03635
uniprot id: H8GQB4
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

686340:METAL RS07360
gene id: 686340:METAL_RS07360
uniprot id: H8GKX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

686340:METAL RS17280
gene id: 686340:METAL_RS17280
uniprot id: H8GGD0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

686340:METAL RS04380
gene id: 686340:METAL_RS04380
uniprot id: H8GFW6
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

686340:METAL RS13115
gene id: 686340:METAL_RS13115
uniprot id: H8GKC5
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

686340:METAL RS18610
gene id: 686340:METAL_RS18610
uniprot id: H8GIG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP H family.
messages: Cell inner membrane
messages: Membrane

686340:METAL RS19320
gene id: 686340:METAL_RS19320
uniprot id: H8GJS7
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

686340:METAL RS01460
gene id: 686340:METAL_RS01460
uniprot id: H8GLW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

686340:METAL RS04960
gene id: 686340:METAL_RS04960
uniprot id: H8GGN5
names: Function
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

686340:METAL RS08790
gene id: 686340:METAL_RS08790
uniprot id: H8GNI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

686340:METAL RS06420
gene id: 686340:METAL_RS06420
uniprot id: H8GJC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

686340:METAL RS09745
gene id: 686340:METAL_RS09745
uniprot id: H8GPZ4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS13105
gene id: 686340:METAL_RS13105
uniprot id: H8GKB9
names: Similarity
messages: Belongs to the transposase 11 family.

686340:METAL RS12815
gene id: 686340:METAL_RS12815
uniprot id: H8GJJ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

686340:METAL RS08645
gene id: 686340:METAL_RS08645
uniprot id: H8GNF5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

686340:METAL RS09420
gene id: 686340:METAL_RS09420
uniprot id: H8GPS8
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

686340:METAL RS08240
gene id: 686340:METAL_RS08240
uniprot id: H8GMR0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

686340:METAL RS10420
gene id: 686340:METAL_RS10420
uniprot id: H8GR73
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS09135
gene id: 686340:METAL_RS09135
uniprot id: H8GP63
names: Similarity
messages: Belongs to the RecJ family.

686340:METAL RS01515
gene id: 686340:METAL_RS01515
uniprot id: H8GLX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

686340:METAL RS13745
gene id: 686340:METAL_RS13745
uniprot id: H8GL50
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

686340:METAL RS18235
gene id: 686340:METAL_RS18235
uniprot id: H8GHT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

686340:METAL RS03720
gene id: 686340:METAL_RS03720
uniprot id: H8GQD1
names: Similarity
messages: Belongs to the Rsd/AlgQ family.

686340:METAL RS18925
gene id: 686340:METAL_RS18925
uniprot id: H8GJ29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

686340:METAL RS01905
gene id: 686340:METAL_RS01905
uniprot id: H8GMK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

686340:METAL RS12810
gene id: 686340:METAL_RS12810
uniprot id: H8GJJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

686340:METAL RS17725
gene id: 686340:METAL_RS17725
uniprot id: H8GH22
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

686340:METAL RS14770
gene id: 686340:METAL_RS14770
uniprot id: H8GN17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

686340:METAL RS08535
gene id: 686340:METAL_RS08535
uniprot id: H8GMX2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

686340:METAL RS02855
gene id: 686340:METAL_RS02855
uniprot id: H8GP05
names: Function
messages: Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.

686340:METAL RS16885
gene id: 686340:METAL_RS16885
uniprot id: H8GRF3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

686340:METAL RS06940
gene id: 686340:METAL_RS06940
uniprot id: H8GK87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

686340:METAL RS05270
gene id: 686340:METAL_RS05270
uniprot id: H8GH99
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

686340:METAL RS17165
gene id: 686340:METAL_RS17165
uniprot id: H8GGA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

686340:METAL RS01840
gene id: 686340:METAL_RS01840
uniprot id: H8GMJ1
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS09635
gene id: 686340:METAL_RS09635
uniprot id: H8GPX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

686340:METAL RS08775
gene id: 686340:METAL_RS08775
uniprot id: H8GNI1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Cell membrane
messages: Membrane
messages: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

686340:METAL RS13490
gene id: 686340:METAL_RS13490
uniprot id: H8GL02
names: Similarity
messages: Belongs to the carbamate kinase family.

686340:METAL RS04775
gene id: 686340:METAL_RS04775
uniprot id: H8GGJ8
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.
messages: Methylates ribosomal protein uL3 on a specific glutamine residue.

686340:METAL RS07515
gene id: 686340:METAL_RS07515
uniprot id: H8GLG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

686340:METAL RS19330
gene id: 686340:METAL_RS19330
uniprot id: H8GJS9
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS10690
gene id: 686340:METAL_RS10690
uniprot id: H8GG25
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

686340:METAL RS02220
gene id: 686340:METAL_RS02220
uniprot id: H8GN78
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS1 family.
messages: Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.

686340:METAL RS15655
gene id: 686340:METAL_RS15655
uniprot id: H8GPF3
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.

686340:METAL RS15950
gene id: 686340:METAL_RS15950
uniprot id: H8GQ18
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

686340:METAL RS01145
gene id: 686340:METAL_RS01145
uniprot id: H8GL98
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

686340:METAL RS19035
gene id: 686340:METAL_RS19035
uniprot id: H8GJ51
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

686340:METAL RS05375
gene id: 686340:METAL_RS05375
uniprot id: H8GHC1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'P' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Non-allosteric.

686340:METAL RS12490
gene id: 686340:METAL_RS12490
uniprot id: H8GIU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homodimer.

686340:METAL RS14105
gene id: 686340:METAL_RS14105
uniprot id: H8GLS2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
messages: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

686340:METAL RS03975
gene id: 686340:METAL_RS03975
uniprot id: H8GQX9
names: Function
messages: This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.

686340:METAL RS15165
gene id: 686340:METAL_RS15165
uniprot id: H8GNQ0
names: Similarity
messages: Belongs to the YkuD family.

686340:METAL RS18035
gene id: 686340:METAL_RS18035
uniprot id: H8GHP2
names: Similarity
messages: Belongs to the GSP E family.

686340:METAL RS12940
gene id: 686340:METAL_RS12940
uniprot id: H8GJM0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS08555
gene id: 686340:METAL_RS08555
uniprot id: H8GMX7
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

686340:METAL RS14355
gene id: 686340:METAL_RS14355
uniprot id: H8GMC5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS19050
gene id: 686340:METAL_RS19050
uniprot id: H8GJ54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

686340:METAL RS06415
gene id: 686340:METAL_RS06415
uniprot id: H8GJC2
names: Similarity
messages: Belongs to the ribosome association toxin RatA family.

686340:METAL RS04285
gene id: 686340:METAL_RS04285
uniprot id: H8GFU6
names: Function
names: Similarity
messages: Belongs to the ribF family.
messages: Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.

686340:METAL RS09395
gene id: 686340:METAL_RS09395
uniprot id: H8GPS3
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.

686340:METAL RS14790
gene id: 686340:METAL_RS14790
uniprot id: H8GN21
names: Similarity
messages: Belongs to the YkuD family.

686340:METAL RS06895
gene id: 686340:METAL_RS06895
uniprot id: H8GK78
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

686340:METAL RS05035
gene id: 686340:METAL_RS05035
uniprot id: H8GH55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbE subfamily.
messages: Cell inner membrane

686340:METAL RS07145
gene id: 686340:METAL_RS07145
uniprot id: H8GKT0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

686340:METAL RS00015
gene id: 686340:METAL_RS00015
uniprot id: H8GJ59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

686340:METAL RS17155
gene id: 686340:METAL_RS17155
uniprot id: H8GGA5
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS15955
gene id: 686340:METAL_RS15955
uniprot id: H8GQ19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

686340:METAL RS18205
gene id: 686340:METAL_RS18205
uniprot id: H8GHS6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS04135
gene id: 686340:METAL_RS04135
uniprot id: H8GR11
names: Subunit
messages: Monomer. Interacts with PqqE.

686340:METAL RS13615
gene id: 686340:METAL_RS13615
uniprot id: H8GL26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbB/TolQ family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

686340:METAL RS17735
gene id: 686340:METAL_RS17735
uniprot id: H8GH24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic sulfate-binding protein family.
messages: Periplasm

686340:METAL RS06335
gene id: 686340:METAL_RS06335
uniprot id: H8GJA8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

686340:METAL RS06770
gene id: 686340:METAL_RS06770
uniprot id: H8GK54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

686340:METAL RS06495
gene id: 686340:METAL_RS06495
uniprot id: H8GJD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

686340:METAL RS01775
gene id: 686340:METAL_RS01775
uniprot id: H8GMH8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiD family.
messages: Binds 1 prenylated FMN (prenyl-FMN) per subunit.
messages: Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
messages: Cell membrane
messages: Homohexamer.

686340:METAL RS08825
gene id: 686340:METAL_RS08825
uniprot id: H8GNJ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoH subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.

686340:METAL RS05350
gene id: 686340:METAL_RS05350
uniprot id: H8GHB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.

686340:METAL RS05965
gene id: 686340:METAL_RS05965
uniprot id: H8GIJ5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

686340:METAL RS14180
gene id: 686340:METAL_RS14180
uniprot id: H8GLT7
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS08690
gene id: 686340:METAL_RS08690
uniprot id: H8GNG4
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Secreted

686340:METAL RS04785
gene id: 686340:METAL_RS04785
uniprot id: H8GGK0
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS13770
gene id: 686340:METAL_RS13770
uniprot id: H8GL55
names: Function
names: Similarity
messages: Belongs to the bacterioferritin family.
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

686340:METAL RS00385
gene id: 686340:METAL_RS00385
uniprot id: H8GJZ0
names: Similarity
messages: Belongs to the fructosamine kinase family.

686340:METAL RS16520
gene id: 686340:METAL_RS16520
uniprot id: H8GQT1
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

686340:METAL RS07835
gene id: 686340:METAL_RS07835
uniprot id: H8GM29
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

686340:METAL RS12245
gene id: 686340:METAL_RS12245
uniprot id: H8GIQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HflD family.
messages: Cell membrane
messages: Cytoplasm

686340:METAL RS15105
gene id: 686340:METAL_RS15105
uniprot id: H8GNN7
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

686340:METAL RS07130
gene id: 686340:METAL_RS07130
uniprot id: H8GKS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone-like protein H-NS family.
messages: nucleoid

686340:METAL RS18385
gene id: 686340:METAL_RS18385
uniprot id: H8GIC0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Homodimer.

686340:METAL RS09550
gene id: 686340:METAL_RS09550
uniprot id: H8GKC5
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

686340:METAL RS12350
gene id: 686340:METAL_RS12350
uniprot id: H8GIS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

686340:METAL RS13850
gene id: 686340:METAL_RS13850
uniprot id: H8GLM4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CopD family.
messages: Cell inner membrane
messages: Involved in copper resistance.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

686340:METAL RS15565
gene id: 686340:METAL_RS15565
uniprot id: H8GPD5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

686340:METAL RS04410
gene id: 686340:METAL_RS04410
uniprot id: H8GFX2
names: Caution
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
messages: Belongs to the biotin--protein ligase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS09910
gene id: 686340:METAL_RS09910
uniprot id: H8GQH3
names: Similarity
messages: Belongs to the MlaA family.

686340:METAL RS16705
gene id: 686340:METAL_RS16705
uniprot id: H8GRB6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

686340:METAL RS00840
gene id: 686340:METAL_RS00840
uniprot id: H8GKN0
names: PTM
messages: Binds 2 heme c groups covalently per subunit.

686340:METAL RS01230
gene id: 686340:METAL_RS01230
uniprot id: H8GLB5
names: Similarity
messages: Belongs to the peptidase S49 family.

686340:METAL RS14460
gene id: 686340:METAL_RS14460
uniprot id: H8GME5
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS05400
gene id: 686340:METAL_RS05400
uniprot id: H8GHC6
names: Similarity
messages: Belongs to the UPF0047 family.

686340:METAL RS05735
gene id: 686340:METAL_RS05735
uniprot id: H8GHZ2
names: Similarity
messages: Belongs to the HupF/HypC family.

686340:METAL RS14845
gene id: 686340:METAL_RS14845
uniprot id: H8GN32
names: Similarity
messages: Belongs to the DEAD box helicase family.

686340:METAL RS01810
gene id: 686340:METAL_RS01810
uniprot id: H8GMI5
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

686340:METAL RS03660
gene id: 686340:METAL_RS03660
uniprot id: H8GQB9
names: Similarity
names: Subunit
messages: Belongs to the Nudix hydrolase family. NudJ subfamily.
messages: Monomer.

686340:METAL RS15280
gene id: 686340:METAL_RS15280
uniprot id: H8GNS0
names: Similarity
messages: Belongs to the HPS/KGPDC family. HPS subfamily.
messages: Belongs to the SIS family. PHI subfamily.

686340:METAL RS05900
gene id: 686340:METAL_RS05900
uniprot id: H8GII2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

686340:METAL RS15170
gene id: 686340:METAL_RS15170
uniprot id: H8GNQ1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS04995
gene id: 686340:METAL_RS04995
uniprot id: H8GGP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

686340:METAL RS09040
gene id: 686340:METAL_RS09040
uniprot id: H8GP42
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

686340:METAL RS16090
gene id: 686340:METAL_RS16090
uniprot id: H8GQ48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

686340:METAL RS02870
gene id: 686340:METAL_RS02870
uniprot id: H8GP08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

686340:METAL RS15435
gene id: 686340:METAL_RS15435
uniprot id: H8GNV0
names: Subcellular Location Annotation
messages: Nucleus

686340:METAL RS17815
gene id: 686340:METAL_RS17815
uniprot id: H8GH41
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

686340:METAL RS13210
gene id: 686340:METAL_RS13210
uniprot id: H8GKE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

686340:METAL RS01005
gene id: 686340:METAL_RS01005
uniprot id: H8GL73
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

686340:METAL RS00545
gene id: 686340:METAL_RS00545
uniprot id: H8GK23
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

686340:METAL RS05280
gene id: 686340:METAL_RS05280
uniprot id: H8GHA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

686340:METAL RS06470
gene id: 686340:METAL_RS06470
uniprot id: H8GJD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

686340:METAL RS00280
gene id: 686340:METAL_RS00280
uniprot id: H8GJW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

686340:METAL RS09930
gene id: 686340:METAL_RS09930
uniprot id: H8GQH7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

686340:METAL RS04635
gene id: 686340:METAL_RS04635
uniprot id: H8GGH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

686340:METAL RS08230
gene id: 686340:METAL_RS08230
uniprot id: H8GMQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dsrC/tusE family.
messages: Cytoplasm
messages: Part of a sulfur-relay system.

686340:METAL RS16015
gene id: 686340:METAL_RS16015
uniprot id: H8GQ32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

686340:METAL RS13040
gene id: 686340:METAL_RS13040
uniprot id: H8GKA7
names: Similarity
messages: Belongs to the YkuD family.

686340:METAL RS14440
gene id: 686340:METAL_RS14440
uniprot id: H8GME1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

686340:METAL RS18960
gene id: 686340:METAL_RS18960
uniprot id: H8GJ36
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

686340:METAL RS13030
gene id: 686340:METAL_RS13030
uniprot id: H8GKA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecB family.
messages: Cytoplasm
messages: Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.
messages: One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.

686340:METAL RS19100
gene id: 686340:METAL_RS19100
uniprot id: H8GJP2
names: Similarity
messages: Belongs to the archease family.

686340:METAL RS02065
gene id: 686340:METAL_RS02065
uniprot id: H8GMN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

686340:METAL RS13325
gene id: 686340:METAL_RS13325
uniprot id: H8GKG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

686340:METAL RS16080
gene id: 686340:METAL_RS16080
uniprot id: H8GQ46
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

686340:METAL RS17455
gene id: 686340:METAL_RS17455
uniprot id: H8GGX0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Monomer.

686340:METAL RS05430
gene id: 686340:METAL_RS05430
uniprot id: H8GHT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

686340:METAL RS14800
gene id: 686340:METAL_RS14800
uniprot id: H8GN23
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

686340:METAL RS18805
gene id: 686340:METAL_RS18805
uniprot id: H8GJ06
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

686340:METAL RS14085
gene id: 686340:METAL_RS14085
uniprot id: H8GLR8
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS03750
gene id: 686340:METAL_RS03750
uniprot id: H8GQD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Cell inner membrane
messages: Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins.
messages: Membrane

686340:METAL RS08770
gene id: 686340:METAL_RS08770
uniprot id: H8GKC5
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

686340:METAL RS06480
gene id: 686340:METAL_RS06480
uniprot id: H8GJD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

686340:METAL RS14425
gene id: 686340:METAL_RS14425
uniprot id: H8GMD8
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Involved in a late step of protoheme IX synthesis.
messages: Membrane

686340:METAL RS06385
gene id: 686340:METAL_RS06385
uniprot id: H8GJB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
messages: The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE).

686340:METAL RS06955
gene id: 686340:METAL_RS06955
uniprot id: H8GK90
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

686340:METAL RS05200
gene id: 686340:METAL_RS05200
uniprot id: H8GH86
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

686340:METAL RS06060
gene id: 686340:METAL_RS06060
uniprot id: H8GIL2
names: Similarity
messages: Belongs to the TelA family.

686340:METAL RS18315
gene id: 686340:METAL_RS18315
uniprot id: H8GIA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

686340:METAL RS05040
gene id: 686340:METAL_RS05040
uniprot id: H8GH56
names: Function
names: Similarity
messages: Belongs to the CcmH/CycL/Ccl2/NrfF family.
messages: Possible subunit of a heme lyase.

686340:METAL RS08665
gene id: 686340:METAL_RS08665
uniprot id: H8GNF9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

686340:METAL RS01150
gene id: 686340:METAL_RS01150
uniprot id: H8GL99
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS10405
gene id: 686340:METAL_RS10405
uniprot id: H8GR70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

686340:METAL RS04740
gene id: 686340:METAL_RS04740
uniprot id: H8GGJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane

686340:METAL RS07120
gene id: 686340:METAL_RS07120
uniprot id: H8GKS5
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

686340:METAL RS04640
gene id: 686340:METAL_RS04640
uniprot id: H8GGH2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

686340:METAL RS09350
gene id: 686340:METAL_RS09350
uniprot id: H8GPA7
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

686340:METAL RS11230
gene id: 686340:METAL_RS11230
uniprot id: H8GGT8
names: Cofactor
messages: Binds 1 copper ion per subunit.

686340:METAL RS07065
gene id: 686340:METAL_RS07065
uniprot id: H8GKR4
names: Similarity
messages: Belongs to the complex I 75 kDa subunit family.
messages: In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

686340:METAL RS16005
gene id: 686340:METAL_RS16005
uniprot id: H8GQ30
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

686340:METAL RS06790
gene id: 686340:METAL_RS06790
uniprot id: H8GK57
names: Cofactor
names: Similarity
messages: Belongs to the bacterial PQQ dehydrogenase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Binds 1 PQQ group per subunit.

686340:METAL RS02320
gene id: 686340:METAL_RS02320
uniprot id: H8GN96
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS03610
gene id: 686340:METAL_RS03610
uniprot id: H8GQA9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

686340:METAL RS12930
gene id: 686340:METAL_RS12930
uniprot id: H8GJL8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS03535
gene id: 686340:METAL_RS03535
uniprot id: H8GQ95
names: Similarity
messages: Belongs to the HsdR family.

686340:METAL RS00920
gene id: 686340:METAL_RS00920
uniprot id: H8GKP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

686340:METAL RS07150
gene id: 686340:METAL_RS07150
uniprot id: H8GKT1
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

686340:METAL RS05685
gene id: 686340:METAL_RS05685
uniprot id: H8GHY2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

686340:METAL RS04540
gene id: 686340:METAL_RS04540
uniprot id: H8GFZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein SsuA/TauA family.
messages: Periplasm

686340:METAL RS01195
gene id: 686340:METAL_RS01195
uniprot id: H8GLA8
names: Function
names: Similarity
messages: Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1.B.42) family.
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system.

686340:METAL RS02625
gene id: 686340:METAL_RS02625
uniprot id: H8GNW1
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS14310
gene id: 686340:METAL_RS14310
uniprot id: H8GMB6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS08605
gene id: 686340:METAL_RS08605
uniprot id: H8GMY7
names: Function
names: Similarity
messages: Belongs to the FlgM family.
messages: Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.

686340:METAL RS09210
gene id: 686340:METAL_RS09210
uniprot id: H8GP79
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

686340:METAL RS10165
gene id: 686340:METAL_RS10165
uniprot id: H8GKC5
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

686340:METAL RS13560
gene id: 686340:METAL_RS13560
uniprot id: H8GL15
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HemJ family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

686340:METAL RS13380
gene id: 686340:METAL_RS13380
uniprot id: H8GKH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

686340:METAL RS04570
gene id: 686340:METAL_RS04570
uniprot id: H8GG03
names: Similarity
messages: Belongs to the CvfB family.

686340:METAL RS11720
gene id: 686340:METAL_RS11720
uniprot id: H8GHJ0
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

686340:METAL RS12025
gene id: 686340:METAL_RS12025
uniprot id: H8GI55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

686340:METAL RS16610
gene id: 686340:METAL_RS16610
uniprot id: H8GQU3
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

686340:METAL RS16100
gene id: 686340:METAL_RS16100
uniprot id: H8GQ50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

686340:METAL RS17920
gene id: 686340:METAL_RS17920
uniprot id: H8GHL9
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

686340:METAL RS04825
gene id: 686340:METAL_RS04825
uniprot id: H8GGK8
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

686340:METAL RS09795
gene id: 686340:METAL_RS09795
uniprot id: H8GQF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane

686340:METAL RS07490
gene id: 686340:METAL_RS07490
uniprot id: H8GLF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

686340:METAL RS13840
gene id: 686340:METAL_RS13840
uniprot id: H8GLM2
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

686340:METAL RS13170
gene id: 686340:METAL_RS13170
uniprot id: H8GKD4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

686340:METAL RS10485
gene id: 686340:METAL_RS10485
uniprot id: H8GR85
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

686340:METAL RS05880
gene id: 686340:METAL_RS05880
uniprot id: H8GIH8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

686340:METAL RS14415
gene id: 686340:METAL_RS14415
uniprot id: H8GMD6
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

686340:METAL RS15295
gene id: 686340:METAL_RS15295
uniprot id: H8GNS3
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS00415
gene id: 686340:METAL_RS00415
uniprot id: H8GJZ7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

686340:METAL RS17880
gene id: 686340:METAL_RS17880
uniprot id: H8GHL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

686340:METAL RS15995
gene id: 686340:METAL_RS15995
uniprot id: H8GQ28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

686340:METAL RS02750
gene id: 686340:METAL_RS02750
uniprot id: H8GNY5
names: Similarity
messages: Belongs to the pirin family.

686340:METAL RS19220
gene id: 686340:METAL_RS19220
uniprot id: H8GJR1
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS14860
gene id: 686340:METAL_RS14860
uniprot id: H8GN35
names: Subcellular Location Annotation
messages: Cytoplasm

686340:METAL RS14010
gene id: 686340:METAL_RS14010
uniprot id: H8GKC5
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

686340:METAL RS15750
gene id: 686340:METAL_RS15750
uniprot id: H8GPH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

686340:METAL RS09165
gene id: 686340:METAL_RS09165
uniprot id: H8GKC5
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

686340:METAL RS16065
gene id: 686340:METAL_RS16065
uniprot id: H8GQ43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

686340:METAL RS15290
gene id: 686340:METAL_RS15290
uniprot id: H8GNS2
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

686340:METAL RS06830
gene id: 686340:METAL_RS06830
uniprot id: H8GK65
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

686340:METAL RS14110
gene id: 686340:METAL_RS14110
uniprot id: H8GLS3
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

686340:METAL RS07870
gene id: 686340:METAL_RS07870
uniprot id: H8GM36
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

686340:METAL RS00935
gene id: 686340:METAL_RS00935
uniprot id: H8GKP9
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

686340:METAL RS13485
gene id: 686340:METAL_RS13485
uniprot id: H8GL01
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS03830
gene id: 686340:METAL_RS03830
uniprot id: H8GQV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

686340:METAL RS05330
gene id: 686340:METAL_RS05330
uniprot id: H8GHB2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS05425
gene id: 686340:METAL_RS05425
uniprot id: H8GHT8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

686340:METAL RS04620
gene id: 686340:METAL_RS04620
uniprot id: H8GGG8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

686340:METAL RS19020
gene id: 686340:METAL_RS19020
uniprot id: H8GJ48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

686340:METAL RS17515
gene id: 686340:METAL_RS17515
uniprot id: H8GGY2
names: Similarity
messages: Belongs to the glutathione peroxidase family.

686340:METAL RS09730
gene id: 686340:METAL_RS09730
uniprot id: H8GPZ1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

686340:METAL RS10160
gene id: 686340:METAL_RS10160
uniprot id: H8GQM4
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

686340:METAL RS00245
gene id: 686340:METAL_RS00245
uniprot id: H8GJW2
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

686340:METAL RS04875
gene id: 686340:METAL_RS04875
uniprot id: H8GGL8
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

686340:METAL RS08125
gene id: 686340:METAL_RS08125
uniprot id: H8GM81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TamA family.
messages: Cell outer membrane
messages: Membrane

686340:METAL RS12255
gene id: 686340:METAL_RS12255
uniprot id: H8GIQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

686340:METAL RS08940
gene id: 686340:METAL_RS08940
uniprot id: H8GNL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

686340:METAL RS12805
gene id: 686340:METAL_RS12805
uniprot id: H8GJJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0060 family.
messages: Cell membrane

686340:METAL RS09935
gene id: 686340:METAL_RS09935
uniprot id: H8GQH8
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

686340:METAL RS02755
gene id: 686340:METAL_RS02755
uniprot id: H8GNY6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

686340:METAL RS19025
gene id: 686340:METAL_RS19025
uniprot id: H8GJ49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

686340:METAL RS11520
gene id: 686340:METAL_RS11520
uniprot id: H8GHF3
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

686340:METAL RS16190
gene id: 686340:METAL_RS16190
uniprot id: H8GQ63
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

686340:METAL RS14340
gene id: 686340:METAL_RS14340
uniprot id: H8GMC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

686340:METAL RS16660
gene id: 686340:METAL_RS16660
uniprot id: H8GRA7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably interacts with PlsX.

686340:METAL RS08780
gene id: 686340:METAL_RS08780
uniprot id: H8GNI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

686340:METAL RS03175
gene id: 686340:METAL_RS03175
uniprot id: H8GPM6
names: Similarity
messages: Belongs to the CbbQ/NirQ/NorQ/GpvN family.

686340:METAL RS11660
gene id: 686340:METAL_RS11660
uniprot id: H8GHH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

686340:METAL RS00505
gene id: 686340:METAL_RS00505
uniprot id: H8GK16
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

686340:METAL RS06485
gene id: 686340:METAL_RS06485
uniprot id: H8GJD6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

686340:METAL RS19080
gene id: 686340:METAL_RS19080
uniprot id: H8GJN8
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

686340:METAL RS16820
gene id: 686340:METAL_RS16820
uniprot id: H8GRE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Cob(I)alamin adenosyltransferase family.
messages: Cytoplasm
messages: Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids.

686340:METAL RS06050
gene id: 686340:METAL_RS06050
uniprot id: H8GQY6
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

686340:METAL RS00640
gene id: 686340:METAL_RS00640
uniprot id: H8GKJ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.

686340:METAL RS06880
gene id: 686340:METAL_RS06880
uniprot id: H8GK75
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 FMN per subunit.

686340:METAL RS06800
gene id: 686340:METAL_RS06800
uniprot id: H8GK60
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

686340:METAL RS15875
gene id: 686340:METAL_RS15875
uniprot id: H8GQ04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Periplasm
messages: Secreted

686340:METAL RS03415
gene id: 686340:METAL_RS03415
uniprot id: H8GQ76
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

686340:METAL RS05765
gene id: 686340:METAL_RS05765
uniprot id: H8GHZ8
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

686340:METAL RS17765
gene id: 686340:METAL_RS17765
uniprot id: H8GH31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

686340:METAL RS16075
gene id: 686340:METAL_RS16075
uniprot id: H8GQ45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

686340:METAL RS10600
gene id: 686340:METAL_RS10600
uniprot id: H8GRA6
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

686340:METAL RS02600
gene id: 686340:METAL_RS02600
uniprot id: H8GNV6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

686340:METAL RS06700
gene id: 686340:METAL_RS06700
uniprot id: H8GK39
names: Similarity
messages: Belongs to the phosphohexose mutase family.

686340:METAL RS09385
gene id: 686340:METAL_RS09385
uniprot id: H8GPS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

686340:METAL RS19910
gene id: 686340:METAL_RS19910
uniprot id: H8GMU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

686340:METAL RS18190
gene id: 686340:METAL_RS18190
uniprot id: H8GHS3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

686340:METAL RS01805
gene id: 686340:METAL_RS01805
uniprot id: H8GMI4
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

686340:METAL RS00450
gene id: 686340:METAL_RS00450
uniprot id: H8GK05
names: Similarity
messages: Belongs to the FrmR/RcnR family.

686340:METAL RS03435
gene id: 686340:METAL_RS03435
uniprot id: H8GQ79
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

686340:METAL RS18440
gene id: 686340:METAL_RS18440
uniprot id: H8GID0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS16790
gene id: 686340:METAL_RS16790
uniprot id: H8GRD4
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

686340:METAL RS15895
gene id: 686340:METAL_RS15895
uniprot id: H8GQ07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Cytoplasm

686340:METAL RS15300
gene id: 686340:METAL_RS15300
uniprot id: H8GNS4
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

686340:METAL RS06910
gene id: 686340:METAL_RS06910
uniprot id: H8GK81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

686340:METAL RS12100
gene id: 686340:METAL_RS12100
uniprot id: H8GI70
names: Function
names: Similarity
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family.
messages: In the N-terminal section; belongs to the proline dehydrogenase family.
messages: Oxidizes proline to glutamate for use as a carbon and nitrogen source.

686340:METAL RS05815
gene id: 686340:METAL_RS05815
uniprot id: H8GI08
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

686340:METAL RS14690
gene id: 686340:METAL_RS14690
uniprot id: H8GN01
names: Function
names: Subunit
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.

686340:METAL RS15940
gene id: 686340:METAL_RS15940
uniprot id: H8GQ16
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

686340:METAL RS17230
gene id: 686340:METAL_RS17230
uniprot id: H8GGC0
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

686340:METAL RS18185
gene id: 686340:METAL_RS18185
uniprot id: H8GHS2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

686340:METAL RS17460
gene id: 686340:METAL_RS17460
uniprot id: H8GGX1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds 1 Fe(2+) cation per monomer.
messages: Binds 1 nickel ion per monomer.
messages: Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

686340:METAL RS11655
gene id: 686340:METAL_RS11655
uniprot id: H8GHH7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
messages: Homodimer.

686340:METAL RS06505
gene id: 686340:METAL_RS06505
uniprot id: H8GJE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

686340:METAL RS02620
gene id: 686340:METAL_RS02620
uniprot id: H8GNW0
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS18725
gene id: 686340:METAL_RS18725
uniprot id: H8GIZ2
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

686340:METAL RS04515
gene id: 686340:METAL_RS04515
uniprot id: H8GFZ3
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

686340:METAL RS07265
gene id: 686340:METAL_RS07265
uniprot id: H8GKV4
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

686340:METAL RS12780
gene id: 686340:METAL_RS12780
uniprot id: H8GJJ2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

686340:METAL RS12785
gene id: 686340:METAL_RS12785
uniprot id: H8GJJ3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

686340:METAL RS19605
gene id: 686340:METAL_RS19605
uniprot id: H8GRL8
names: Function
names: Similarity
messages: Belongs to the RecD family. RecD-like subfamily.
messages: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.

686340:METAL RS04025
gene id: 686340:METAL_RS04025
uniprot id: H8GQZ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.

686340:METAL RS08700
gene id: 686340:METAL_RS08700
uniprot id: H8GNG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

686340:METAL RS10605
gene id: 686340:METAL_RS10605
uniprot id: H8GG10
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.

686340:METAL RS07700
gene id: 686340:METAL_RS07700
uniprot id: H8GLJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

686340:METAL RS06375
gene id: 686340:METAL_RS06375
uniprot id: H8GJB4
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS03965
gene id: 686340:METAL_RS03965
uniprot id: H8GQX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell inner membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

686340:METAL RS16060
gene id: 686340:METAL_RS16060
uniprot id: H8GQ42
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

686340:METAL RS15910
gene id: 686340:METAL_RS15910
uniprot id: H8GQ10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

686340:METAL RS00285
gene id: 686340:METAL_RS00285
uniprot id: H8GJX0
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

686340:METAL RS13805
gene id: 686340:METAL_RS13805
uniprot id: H8GL61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

686340:METAL RS10900
gene id: 686340:METAL_RS10900
uniprot id: H8GG66
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

686340:METAL RS07165
gene id: 686340:METAL_RS07165
uniprot id: H8GKT4
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

686340:METAL RS10440
gene id: 686340:METAL_RS10440
uniprot id: H8GR76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

686340:METAL RS07355
gene id: 686340:METAL_RS07355
uniprot id: H8GKX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

686340:METAL RS12120
gene id: 686340:METAL_RS12120
uniprot id: H8GI74
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

686340:METAL RS05170
gene id: 686340:METAL_RS05170
uniprot id: H8GH80
names: Similarity
messages: Belongs to the glycosyl hydrolase 30 family.

686340:METAL RS12875
gene id: 686340:METAL_RS12875
uniprot id: H8GJK7
names: Subunit
messages: Homodimer.

686340:METAL RS09045
gene id: 686340:METAL_RS09045
uniprot id: H8GP43
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

686340:METAL RS08350
gene id: 686340:METAL_RS08350
uniprot id: H8GMT4
names: Similarity
messages: Belongs to the ArsC family.

686340:METAL RS05535
gene id: 686340:METAL_RS05535
uniprot id: H8GHV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

686340:METAL RS15255
gene id: 686340:METAL_RS15255
uniprot id: H8GNR5
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

686340:METAL RS08985
gene id: 686340:METAL_RS08985
uniprot id: H8GNM4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

686340:METAL RS16785
gene id: 686340:METAL_RS16785
uniprot id: H8GRD3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

686340:METAL RS14760
gene id: 686340:METAL_RS14760
uniprot id: H8GN15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

686340:METAL RS15990
gene id: 686340:METAL_RS15990
uniprot id: H8GQ27
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

686340:METAL RS13720
gene id: 686340:METAL_RS13720
uniprot id: H8GL45
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
messages: Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS08480
gene id: 686340:METAL_RS08480
uniprot id: H8GMW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Cell membrane
messages: Membrane
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

686340:METAL RS02200
gene id: 686340:METAL_RS02200
uniprot id: H8GN74
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

686340:METAL RS17990
gene id: 686340:METAL_RS17990
uniprot id: H8GHN3
names: Similarity
messages: Belongs to the KAE1 / TsaD family. TsaB subfamily.

686340:METAL RS06840
gene id: 686340:METAL_RS06840
uniprot id: H8GK67
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

686340:METAL RS16105
gene id: 686340:METAL_RS16105
uniprot id: H8GQ51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

686340:METAL RS14300
gene id: 686340:METAL_RS14300
uniprot id: H8GMB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
messages: Cytoplasm
messages: Monomer.
messages: The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.

686340:METAL RS06095
gene id: 686340:METAL_RS06095
uniprot id: H8GIM0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

686340:METAL RS09850
gene id: 686340:METAL_RS09850
uniprot id: H8GQG2
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

686340:METAL RS07415
gene id: 686340:METAL_RS07415
uniprot id: H8GKY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

686340:METAL RS11310
gene id: 686340:METAL_RS11310
uniprot id: H8GGV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

686340:METAL RS13335
gene id: 686340:METAL_RS13335
uniprot id: H8GKG3
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

686340:METAL RS10610
gene id: 686340:METAL_RS10610
uniprot id: H8GG11
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

686340:METAL RS12770
gene id: 686340:METAL_RS12770
uniprot id: H8GJJ0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS16480
gene id: 686340:METAL_RS16480
uniprot id: H8GQS3
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

686340:METAL RS10540
gene id: 686340:METAL_RS10540
uniprot id: H8GR94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

686340:METAL RS18945
gene id: 686340:METAL_RS18945
uniprot id: H8GJ33
names: Cofactor
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.

686340:METAL RS01475
gene id: 686340:METAL_RS01475
uniprot id: H8GLW7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

686340:METAL RS04820
gene id: 686340:METAL_RS04820
uniprot id: H8GGK7
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

686340:METAL RS05720
gene id: 686340:METAL_RS05720
uniprot id: H8GHY9
names: Similarity
names: Subunit
messages: Belongs to the complex I 75 kDa subunit family.
messages: Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex.

686340:METAL RS02225
gene id: 686340:METAL_RS02225
uniprot id: H8GN79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

686340:METAL RS02710
gene id: 686340:METAL_RS02710
uniprot id: H8GNX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UreE family.
messages: Cytoplasm
messages: Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.

686340:METAL RS16380
gene id: 686340:METAL_RS16380
uniprot id: H8GQQ5
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

686340:METAL RS13870
gene id: 686340:METAL_RS13870
uniprot id: H8GLM8
names: Similarity
messages: Belongs to the oxoprolinase family.

686340:METAL RS05255
gene id: 686340:METAL_RS05255
uniprot id: H8GH96
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

686340:METAL RS16645
gene id: 686340:METAL_RS16645
uniprot id: H8GQU9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

686340:METAL RS01740
gene id: 686340:METAL_RS01740
uniprot id: H8GM17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane
messages: Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.

686340:METAL RS10290
gene id: 686340:METAL_RS10290
uniprot id: H8GR48
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

686340:METAL RS07260
gene id: 686340:METAL_RS07260
uniprot id: H8GKV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

686340:METAL RS05340
gene id: 686340:METAL_RS05340
uniprot id: H8GHB4
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

686340:METAL RS18460
gene id: 686340:METAL_RS18460
uniprot id: H8GID4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

686340:METAL RS09710
gene id: 686340:METAL_RS09710
uniprot id: H8GPY7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS10575
gene id: 686340:METAL_RS10575
uniprot id: H8GRA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

686340:METAL RS04030
gene id: 686340:METAL_RS04030
uniprot id: H8GQZ1
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

686340:METAL RS09125
gene id: 686340:METAL_RS09125
uniprot id: H8GP60
names: Similarity
messages: Belongs to the NodU/CmcH family.

686340:METAL RS07245
gene id: 686340:METAL_RS07245
uniprot id: H8GKV0
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase class-III family.

686340:METAL RS10465
gene id: 686340:METAL_RS10465
uniprot id: H8GR81
names: Similarity
messages: Belongs to the aspartokinase family.

686340:METAL RS08955
gene id: 686340:METAL_RS08955
uniprot id: H8GNL7
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

686340:METAL RS08990
gene id: 686340:METAL_RS08990
uniprot id: H8GNM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZipA family.
messages: Cell inner membrane
messages: Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.

686340:METAL RS18015
gene id: 686340:METAL_RS18015
uniprot id: H8GHN8
names: Similarity
messages: Belongs to the DsrF/TusC family.

686340:METAL RS04700
gene id: 686340:METAL_RS04700
uniprot id: H8GGI2
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

686340:METAL RS09940
gene id: 686340:METAL_RS09940
uniprot id: H8GQH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

686340:METAL RS07255
gene id: 686340:METAL_RS07255
uniprot id: H8GKV2
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS16155
gene id: 686340:METAL_RS16155
uniprot id: H8GQ57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

686340:METAL RS08455
gene id: 686340:METAL_RS08455
uniprot id: H8GMV6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

686340:METAL RS05180
gene id: 686340:METAL_RS05180
uniprot id: H8GH82
names: Similarity
messages: Belongs to the peptidase S11 family.

686340:METAL RS11645
gene id: 686340:METAL_RS11645
uniprot id: H8GHH5
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS17915
gene id: 686340:METAL_RS17915
uniprot id: H8GHL8
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.

686340:METAL RS08850
gene id: 686340:METAL_RS08850
uniprot id: H8GNJ7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

686340:METAL RS00790
gene id: 686340:METAL_RS00790
uniprot id: H8GKL9
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

686340:METAL RS15665
gene id: 686340:METAL_RS15665
uniprot id: H8GPF5
names: Similarity
messages: Belongs to the UPF0175 family.
messages: Belongs to the phD/YefM antitoxin family.

686340:METAL RS17500
gene id: 686340:METAL_RS17500
uniprot id: H8GGX9
names: Subunit
messages: Homodimer.

686340:METAL RS07880
gene id: 686340:METAL_RS07880
uniprot id: H8GM38
names: Similarity
messages: Belongs to the fabD family.

686340:METAL RS08855
gene id: 686340:METAL_RS08855
uniprot id: H8GNJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

686340:METAL RS09390
gene id: 686340:METAL_RS09390
uniprot id: H8GPS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

686340:METAL RS05420
gene id: 686340:METAL_RS05420
uniprot id: H8GHD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

686340:METAL RS15190
gene id: 686340:METAL_RS15190
uniprot id: H8GNQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane

686340:METAL RS13725
gene id: 686340:METAL_RS13725
uniprot id: H8GL46
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
messages: Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
messages: Homodimer.

686340:METAL RS01560
gene id: 686340:METAL_RS01560
uniprot id: H8GLY3
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

686340:METAL RS03760
gene id: 686340:METAL_RS03760
uniprot id: H8GQD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

686340:METAL RS14590
gene id: 686340:METAL_RS14590
uniprot id: H8GMH1
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

686340:METAL RS04055
gene id: 686340:METAL_RS04055
uniprot id: H8GQZ5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

686340:METAL RS17260
gene id: 686340:METAL_RS17260
uniprot id: H8GGC6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

686340:METAL RS15490
gene id: 686340:METAL_RS15490
uniprot id: H8GPC1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

686340:METAL RS04835
gene id: 686340:METAL_RS04835
uniprot id: H8GGL0
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

686340:METAL RS05740
gene id: 686340:METAL_RS05740
uniprot id: H8GHZ3
names: Similarity
messages: Belongs to the HypD family.

686340:METAL RS17670
gene id: 686340:METAL_RS17670
uniprot id: H8GH11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

686340:METAL RS08280
gene id: 686340:METAL_RS08280
uniprot id: H8GMR9
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

686340:METAL RS15785
gene id: 686340:METAL_RS15785
uniprot id: H8GPI0
names: Similarity
messages: Belongs to the YkuD family.

686340:METAL RS05520
gene id: 686340:METAL_RS05520
uniprot id: H8GHV6
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

686340:METAL RS17695
gene id: 686340:METAL_RS17695
uniprot id: H8GH16
names: PTM
messages: Binds 1 heme group per subunit.

686340:METAL RS16690
gene id: 686340:METAL_RS16690
uniprot id: H8GRB3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS08050
gene id: 686340:METAL_RS08050
uniprot id: H8GM69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

686340:METAL RS15575
gene id: 686340:METAL_RS15575
uniprot id: H8GPD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

686340:METAL RS16965
gene id: 686340:METAL_RS16965
uniprot id: H8GRG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

686340:METAL RS06985
gene id: 686340:METAL_RS06985
uniprot id: H8GK96
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

686340:METAL RS14765
gene id: 686340:METAL_RS14765
uniprot id: H8GN16
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrC family.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

686340:METAL RS10415
gene id: 686340:METAL_RS10415
uniprot id: H8GR72
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

686340:METAL RS15715
gene id: 686340:METAL_RS15715
uniprot id: H8GPG6
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS08460
gene id: 686340:METAL_RS08460
uniprot id: H8GMV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

686340:METAL RS09680
gene id: 686340:METAL_RS09680
uniprot id: H8GPY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcdB/MmdB/OadB family.
messages: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
messages: Cell membrane
messages: Heterotrimer of an alpha, a beta and a gamma subunit.
messages: Membrane

686340:METAL RS17560
gene id: 686340:METAL_RS17560
uniprot id: H8GGZ0
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

686340:METAL RS07620
gene id: 686340:METAL_RS07620
uniprot id: H8GLI1
names: Similarity
messages: Belongs to the transposase IS21/IS408/IS1162 family.

686340:METAL RS02865
gene id: 686340:METAL_RS02865
uniprot id: H8GP07
names: Subcellular Location Annotation
messages: Periplasm

686340:METAL RS17565
gene id: 686340:METAL_RS17565
uniprot id: H8GGZ1
names: Function
names: Similarity
names: Subunit
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.
messages: Interacts with MinC and FtsZ.

686340:METAL RS16115
gene id: 686340:METAL_RS16115
uniprot id: H8GQ53
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

686340:METAL RS13650
gene id: 686340:METAL_RS13650
uniprot id: H8GL33
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

686340:METAL RS16030
gene id: 686340:METAL_RS16030
uniprot id: H8GQ35
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

686340:METAL RS11635
gene id: 686340:METAL_RS11635
uniprot id: H8GHH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbC subfamily.
messages: Periplasm
messages: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process.

686340:METAL RS07365
gene id: 686340:METAL_RS07365
uniprot id: H8GKX3
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS00635
gene id: 686340:METAL_RS00635
uniprot id: H8GKJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

686340:METAL RS12210
gene id: 686340:METAL_RS12210
uniprot id: H8GI90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptF/LptG family.
messages: Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).
messages: Membrane
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

686340:METAL RS16795
gene id: 686340:METAL_RS16795
uniprot id: H8GRD5
names: Similarity
messages: Belongs to the HPS/KGPDC family. HPS subfamily.

686340:METAL RS13080
gene id: 686340:METAL_RS13080
uniprot id: H8GKB5
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS03480
gene id: 686340:METAL_RS03480
uniprot id: H8GQ87
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS02210
gene id: 686340:METAL_RS02210
uniprot id: H8GN76
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

686340:METAL RS16335
gene id: 686340:METAL_RS16335
uniprot id: H8GQP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

686340:METAL RS05410
gene id: 686340:METAL_RS05410
uniprot id: H8GHC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

686340:METAL RS14295
gene id: 686340:METAL_RS14295
uniprot id: H8GMB3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

686340:METAL RS18245
gene id: 686340:METAL_RS18245
uniprot id: H8GHT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

686340:METAL RS18640
gene id: 686340:METAL_RS18640
uniprot id: H8GIH1
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

686340:METAL RS12150
gene id: 686340:METAL_RS12150
uniprot id: H8GI79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

686340:METAL RS04470
gene id: 686340:METAL_RS04470
uniprot id: H8GFY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

686340:METAL RS05335
gene id: 686340:METAL_RS05335
uniprot id: H8GHB3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

686340:METAL RS04430
gene id: 686340:METAL_RS04430
uniprot id: H8GFX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

686340:METAL RS13620
gene id: 686340:METAL_RS13620
uniprot id: H8GL27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

686340:METAL RS14265
gene id: 686340:METAL_RS14265
uniprot id: H8GMA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

686340:METAL RS00690
gene id: 686340:METAL_RS00690
uniprot id: H8GKK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

686340:METAL RS09175
gene id: 686340:METAL_RS09175
uniprot id: H8GP72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

686340:METAL RS11565
gene id: 686340:METAL_RS11565
uniprot id: H8GHF9
names: Function
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

686340:METAL RS00480
gene id: 686340:METAL_RS00480
uniprot id: H8GK11
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS15400
gene id: 686340:METAL_RS15400
uniprot id: H8GNU3
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

686340:METAL RS01325
gene id: 686340:METAL_RS01325
uniprot id: H8GLD4
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

686340:METAL RS15965
gene id: 686340:METAL_RS15965
uniprot id: H8GQ22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

686340:METAL RS03600
gene id: 686340:METAL_RS03600
uniprot id: H8GQA7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

686340:METAL RS05745
gene id: 686340:METAL_RS05745
uniprot id: H8GHZ4
names: Similarity
messages: Belongs to the HypE family.

686340:METAL RS03755
gene id: 686340:METAL_RS03755
uniprot id: H8GQD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family. MrdA subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall.
messages: Cell inner membrane

686340:METAL RS05895
gene id: 686340:METAL_RS05895
uniprot id: H8GII1
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

686340:METAL RS08995
gene id: 686340:METAL_RS08995
uniprot id: H8GP33
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS15160
gene id: 686340:METAL_RS15160
uniprot id: H8GNP9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
messages: Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.

686340:METAL RS13300
gene id: 686340:METAL_RS13300
uniprot id: H8GKF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 3 family.
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

686340:METAL RS10450
gene id: 686340:METAL_RS10450
uniprot id: H8GR78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

686340:METAL RS01780
gene id: 686340:METAL_RS01780
uniprot id: H8GMH9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

686340:METAL RS11970
gene id: 686340:METAL_RS11970
uniprot id: H8GI44
names: Cofactor
names: Similarity
messages: Belongs to the bacterial PQQ dehydrogenase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Binds 1 PQQ group per subunit.

686340:METAL RS13480
gene id: 686340:METAL_RS13480
uniprot id: H8GL00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0073 (Hly-III) family.
messages: Membrane

686340:METAL RS07820
gene id: 686340:METAL_RS07820
uniprot id: H8GM26
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS11615
gene id: 686340:METAL_RS11615
uniprot id: H8GHG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

686340:METAL RS07790
gene id: 686340:METAL_RS07790
uniprot id: H8GLL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

686340:METAL RS01200
gene id: 686340:METAL_RS01200
uniprot id: H8GLA9
names: Function
names: Similarity
messages: Belongs to the sigma-54 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

686340:METAL RS14810
gene id: 686340:METAL_RS14810
uniprot id: H8GN25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

686340:METAL RS05885
gene id: 686340:METAL_RS05885
uniprot id: H8GIH9
names: Similarity
messages: Belongs to the prokaryotic GSH synthase family.

686340:METAL RS01380
gene id: 686340:METAL_RS01380
uniprot id: H8GLU8
names: Similarity
messages: Belongs to the pyruvate kinase family.

686340:METAL RS17305
gene id: 686340:METAL_RS17305
uniprot id: H8GGD5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Catalyzes the dehydration of 6-phospho-D-gluconate to 2-dehydro-3-deoxy-6-phospho-D-gluconate.

686340:METAL RS18325
gene id: 686340:METAL_RS18325
uniprot id: H8GIA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

686340:METAL RS13045
gene id: 686340:METAL_RS13045
uniprot id: H8GKA8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

686340:METAL RS11985
gene id: 686340:METAL_RS11985
uniprot id: H8GI47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methanol dehydrogenase subunit 2 family.
messages: Catalyzes the oxidation of primary alcohols including methanol.
messages: Heterotetramer composed of 2 alpha and 2 beta subunits.

686340:METAL RS04580
gene id: 686340:METAL_RS04580
uniprot id: H8GG05
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
messages: Interacts with the RNAP. Has a higher affinity for the core RNAP than for the holoenzyme. Its ATPase activity is stimulated by binding to RNAP.
messages: Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair.

686340:METAL RS05005
gene id: 686340:METAL_RS05005
uniprot id: H8GGP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmE/CycJ family.
messages: Cell membrane
messages: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.

686340:METAL RS00435
gene id: 686340:METAL_RS00435
uniprot id: H8GK02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

686340:METAL RS15775
gene id: 686340:METAL_RS15775
uniprot id: H8GPH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RdgC family.
messages: May be involved in recombination.
messages: nucleoid

686340:METAL RS03685
gene id: 686340:METAL_RS03685
uniprot id: H8GQC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

686340:METAL RS13060
gene id: 686340:METAL_RS13060
uniprot id: H8GKB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

686340:METAL RS16130
gene id: 686340:METAL_RS16130
uniprot id: H8GQ43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

686340:METAL RS15795
gene id: 686340:METAL_RS15795
uniprot id: H8GPI2
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS15470
gene id: 686340:METAL_RS15470
uniprot id: H8GPB7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

686340:METAL RS00615
gene id: 686340:METAL_RS00615
uniprot id: H8GKI7
names: Similarity
messages: Belongs to the thioredoxin family.

686340:METAL RS03500
gene id: 686340:METAL_RS03500
uniprot id: H8GQ91
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

686340:METAL RS05530
gene id: 686340:METAL_RS05530
uniprot id: H8GHV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

686340:METAL RS07205
gene id: 686340:METAL_RS07205
uniprot id: H8GKU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane

686340:METAL RS00915
gene id: 686340:METAL_RS00915
uniprot id: H8GKP5
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS09300
gene id: 686340:METAL_RS09300
uniprot id: H8GP97
names: Similarity
messages: Belongs to the polysaccharide synthase family.

686340:METAL RS13645
gene id: 686340:METAL_RS13645
uniprot id: H8GL32
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS12355
gene id: 686340:METAL_RS12355
uniprot id: H8GIS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

686340:METAL RS02000
gene id: 686340:METAL_RS02000
uniprot id: H8GMM2
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.

686340:METAL RS04165
gene id: 686340:METAL_RS04165
uniprot id: H8GR18
names: Similarity
messages: Belongs to the peptidase M18 family.

686340:METAL RS06395
gene id: 686340:METAL_RS06395
uniprot id: H8GJB8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

686340:METAL RS04010
gene id: 686340:METAL_RS04010
uniprot id: H8GQY6
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

686340:METAL RS03915
gene id: 686340:METAL_RS03915
uniprot id: H8GQW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

686340:METAL RS08815
gene id: 686340:METAL_RS08815
uniprot id: H8GNJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.

686340:METAL RS07860
gene id: 686340:METAL_RS07860
uniprot id: H8GM34
names: Similarity
names: Subunit
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

686340:METAL RS08575
gene id: 686340:METAL_RS08575
uniprot id: H8GMY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Cell inner membrane
messages: FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

686340:METAL RS16990
gene id: 686340:METAL_RS16990
uniprot id: H8GRH3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS08440
gene id: 686340:METAL_RS08440
uniprot id: H8GMV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Cell inner membrane
messages: FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

686340:METAL RS09520
gene id: 686340:METAL_RS09520
uniprot id: H8GPU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.
messages: Cell membrane
messages: Forms a complex with DabB.
messages: Part of an energy-coupled inorganic carbon pump.

686340:METAL RS09885
gene id: 686340:METAL_RS09885
uniprot id: H8GQG9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS03790
gene id: 686340:METAL_RS03790
uniprot id: H8GQE5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

686340:METAL RS11670
gene id: 686340:METAL_RS11670
uniprot id: H8GHI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

686340:METAL RS05305
gene id: 686340:METAL_RS05305
uniprot id: H8GHA6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.

686340:METAL RS09070
gene id: 686340:METAL_RS09070
uniprot id: H8GP48
names: Subcellular Location Annotation
messages: Cytoplasm

686340:METAL RS14715
gene id: 686340:METAL_RS14715
uniprot id: H8GN06
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS02070
gene id: 686340:METAL_RS02070
uniprot id: H8GMN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

686340:METAL RS15975
gene id: 686340:METAL_RS15975
uniprot id: H8GQ24
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

686340:METAL RS01965
gene id: 686340:METAL_RS01965
uniprot id: H8GML5
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

686340:METAL RS14160
gene id: 686340:METAL_RS14160
uniprot id: H8GLT3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RlmJ family.
messages: Monomer.
messages: Specifically methylates the adenine in position 2030 of 23S rRNA.

686340:METAL RS02550
gene id: 686340:METAL_RS02550
uniprot id: H8GNE1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

686340:METAL RS05080
gene id: 686340:METAL_RS05080
uniprot id: H8GH63
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

686340:METAL RS07435
gene id: 686340:METAL_RS07435
uniprot id: H8GLE3
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

686340:METAL RS08720
gene id: 686340:METAL_RS08720
uniprot id: H8GNH0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS03490
gene id: 686340:METAL_RS03490
uniprot id: H8GQ89
names: Cofactor
names: Similarity
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.

686340:METAL RS05465
gene id: 686340:METAL_RS05465
uniprot id: H8GKC5
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

686340:METAL RS07170
gene id: 686340:METAL_RS07170
uniprot id: H8GKT5
names: Similarity
messages: Belongs to the peptidase S16 family.

686340:METAL RS14365
gene id: 686340:METAL_RS14365
uniprot id: H8GMC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

686340:METAL RS09555
gene id: 686340:METAL_RS09555
uniprot id: H8GPV7
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

686340:METAL RS11265
gene id: 686340:METAL_RS11265
uniprot id: H8GGU5
names: Similarity
messages: Belongs to the OprB family.

686340:METAL RS07075
gene id: 686340:METAL_RS07075
uniprot id: H8GKR6
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

686340:METAL RS18375
gene id: 686340:METAL_RS18375
uniprot id: H8GIB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

686340:METAL RS06780
gene id: 686340:METAL_RS06780
uniprot id: H8GK55
names: Similarity
messages: Belongs to the disproportionating enzyme family.

686340:METAL RS03295
gene id: 686340:METAL_RS03295
uniprot id: H8GPQ0
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

686340:METAL RS17360
gene id: 686340:METAL_RS17360
uniprot id: H8GGE6
names: Function
names: Similarity
messages: Belongs to the PqqB family.
messages: May be involved in the transport of PQQ or its precursor to the periplasm.

686340:METAL RS07600
gene id: 686340:METAL_RS07600
uniprot id: H8GLH7
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS13130
gene id: 686340:METAL_RS13130
uniprot id: H8GKC5
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

686340:METAL RS15610
gene id: 686340:METAL_RS15610
uniprot id: H8GPE5
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

686340:METAL RS07400
gene id: 686340:METAL_RS07400
uniprot id: H8GKY0
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

686340:METAL RS12340
gene id: 686340:METAL_RS12340
uniprot id: H8GIS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

686340:METAL RS18200
gene id: 686340:METAL_RS18200
uniprot id: H8GHS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

686340:METAL RS07140
gene id: 686340:METAL_RS07140
uniprot id: H8GKS9
names: Function
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.
messages: E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

686340:METAL RS06995
gene id: 686340:METAL_RS06995
uniprot id: H8GK98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

686340:METAL RS05930
gene id: 686340:METAL_RS05930
uniprot id: H8GII8
names: Similarity
messages: Belongs to the ModE family.

686340:METAL RS13530
gene id: 686340:METAL_RS13530
uniprot id: H8GL10
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

686340:METAL RS04930
gene id: 686340:METAL_RS04930
uniprot id: H8GGM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiK family.
messages: Cytoplasm
messages: Required for efficient ubiquinone (coenzyme Q) biosynthesis. UbiK is probably an accessory factor of Ubi enzymes and facilitates ubiquinone biosynthesis by acting as an assembly factor, a targeting factor, or both.

686340:METAL RS16230
gene id: 686340:METAL_RS16230
uniprot id: H8GQ72
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.
messages: Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin.

686340:METAL RS01575
gene id: 686340:METAL_RS01575
uniprot id: H8GLY6
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

686340:METAL RS18425
gene id: 686340:METAL_RS18425
uniprot id: H8GIC7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase T family.
messages: Binds two Mg(2+) per subunit. The active form of the enzyme binds two Mg(2+) ions in its active site. The first Mg(2+) forms only one salt bridge with the protein.
messages: Homodimer.
messages: Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis.

686340:METAL RS14815
gene id: 686340:METAL_RS14815
uniprot id: H8GN26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

686340:METAL RS05500
gene id: 686340:METAL_RS05500
uniprot id: H8GHV2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family. MetZ subfamily.
messages: Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide.
messages: Homotetramer.

686340:METAL RS13305
gene id: 686340:METAL_RS13305
uniprot id: H8GKF8
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS18090
gene id: 686340:METAL_RS18090
uniprot id: H8GHQ4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
messages: Belongs to the helicase family. UvrD subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. Interacts with RecA.
messages: The C-terminal domain has nuclease activity and interacts with RecD. It interacts with RecA, facilitating its loading onto ssDNA.
messages: The N-terminal DNA-binding domain is a ssDNA-dependent ATPase and has ATP-dependent 3'-5' helicase function. This domain interacts with RecC.

686340:METAL RS07250
gene id: 686340:METAL_RS07250
uniprot id: H8GKV1
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. ArgA subfamily.
messages: Cytoplasm
messages: In bacteria which possess the bifunctional enzyme ornithine acetyltransferase/N-acetylglutamate synthase (ArgJ), ArgA fulfills an anaplerotic role.

686340:METAL RS08105
gene id: 686340:METAL_RS08105
uniprot id: H8GM78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

686340:METAL RS14530
gene id: 686340:METAL_RS14530
uniprot id: H8GMF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YciB family.
messages: Cell inner membrane
messages: Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.

686340:METAL RS17840
gene id: 686340:METAL_RS17840
uniprot id: H8GH46
names: Function
names: Similarity
names: Subunit
messages: Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.
messages: Belongs to the ZapA family. Type 1 subfamily.
messages: Homodimer. Interacts with FtsZ.

686340:METAL RS02245
gene id: 686340:METAL_RS02245
uniprot id: H8GN82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

686340:METAL RS00195
gene id: 686340:METAL_RS00195
uniprot id: H8GJV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

686340:METAL RS15440
gene id: 686340:METAL_RS15440
uniprot id: H8GNV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

686340:METAL RS12720
gene id: 686340:METAL_RS12720
uniprot id: H8GJI1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
messages: Cytoplasm

686340:METAL RS18790
gene id: 686340:METAL_RS18790
uniprot id: H8GJ03
names: Similarity
messages: Belongs to the peptidase M16 family.

686340:METAL RS02495
gene id: 686340:METAL_RS02495
uniprot id: H8GND0
names: Similarity
messages: Belongs to the asparaginase 1 family.

686340:METAL RS15615
gene id: 686340:METAL_RS15615
uniprot id: H8GPE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
messages: Cytoplasm
messages: Homodimer.

686340:METAL RS14125
gene id: 686340:METAL_RS14125
uniprot id: H8GLS6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

686340:METAL RS14405
gene id: 686340:METAL_RS14405
uniprot id: H8GMD4
names: Function
names: Similarity
messages: Belongs to the MurCDEF family. Mpl subfamily.
messages: Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramate.

686340:METAL RS15945
gene id: 686340:METAL_RS15945
uniprot id: H8GQ17
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

686340:METAL RS18530
gene id: 686340:METAL_RS18530
uniprot id: H8GIE6
names: Similarity
messages: Belongs to the YoeB family.

686340:METAL RS01290
gene id: 686340:METAL_RS01290
uniprot id: H8GLC7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

686340:METAL RS00445
gene id: 686340:METAL_RS00445
uniprot id: H8GK04
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS17510
gene id: 686340:METAL_RS17510
uniprot id: H8GGY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

686340:METAL RS16920
gene id: 686340:METAL_RS16920
uniprot id: H8GRF9
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

686340:METAL RS12800
gene id: 686340:METAL_RS12800
uniprot id: H8GJJ5
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS08415
gene id: 686340:METAL_RS08415
uniprot id: H8GMU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

686340:METAL RS02325
gene id: 686340:METAL_RS02325
uniprot id: H8GN97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane

686340:METAL RS02760
gene id: 686340:METAL_RS02760
uniprot id: H8GNY7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

686340:METAL RS19780
gene id: 686340:METAL_RS19780
uniprot id: H8GQ93
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

686340:METAL RS09630
gene id: 686340:METAL_RS09630
uniprot id: H8GPX2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

686340:METAL RS19230
gene id: 686340:METAL_RS19230
uniprot id: H8GJR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

686340:METAL RS04440
gene id: 686340:METAL_RS04440
uniprot id: H8GFX8
names: Similarity
messages: Belongs to the MoaD family.

686340:METAL RS16760
gene id: 686340:METAL_RS16760
uniprot id: H8GRC8
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

686340:METAL RS01135
gene id: 686340:METAL_RS01135
uniprot id: H8GL96
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Homodimer.

686340:METAL RS09430
gene id: 686340:METAL_RS09430
uniprot id: H8GPS9
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

686340:METAL RS04935
gene id: 686340:METAL_RS04935
uniprot id: H8GGN0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

686340:METAL RS07370
gene id: 686340:METAL_RS07370
uniprot id: H8GKX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

686340:METAL RS06835
gene id: 686340:METAL_RS06835
uniprot id: H8GK66
names: Similarity
messages: Belongs to the PhoH family.

686340:METAL RS18570
gene id: 686340:METAL_RS18570
uniprot id: H8GIF7
names: Similarity
messages: Belongs to the transglycosylase Slt family.

686340:METAL RS04045
gene id: 686340:METAL_RS04045
uniprot id: H8GQZ3
names: Function
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

686340:METAL RS18975
gene id: 686340:METAL_RS18975
uniprot id: H8GJ39
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

686340:METAL RS16070
gene id: 686340:METAL_RS16070
uniprot id: H8GQ44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

686340:METAL RS01295
gene id: 686340:METAL_RS01295
uniprot id: H8GLC8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

686340:METAL RS06605
gene id: 686340:METAL_RS06605
uniprot id: H8GJF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

686340:METAL RS04295
gene id: 686340:METAL_RS04295
uniprot id: H8GFU8
names: Similarity
messages: Belongs to the band 7/mec-2 family.

686340:METAL RS07590
gene id: 686340:METAL_RS07590
uniprot id: H8GLH5
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

686340:METAL RS09205
gene id: 686340:METAL_RS09205
uniprot id: H8GP78
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

686340:METAL RS14290
gene id: 686340:METAL_RS14290
uniprot id: H8GMB2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

686340:METAL RS15110
gene id: 686340:METAL_RS15110
uniprot id: H8GNN9
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

686340:METAL RS05975
gene id: 686340:METAL_RS05975
uniprot id: H8GIJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane

686340:METAL RS03150
gene id: 686340:METAL_RS03150
uniprot id: H8GPM1
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS00355
gene id: 686340:METAL_RS00355
uniprot id: H8GJY4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M20A family. DapE subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
messages: Homodimer.

686340:METAL RS15870
gene id: 686340:METAL_RS15870
uniprot id: H8GQ03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

686340:METAL RS03680
gene id: 686340:METAL_RS03680
uniprot id: H8GQC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-transferase family. Bpt subfamily.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.

686340:METAL RS07025
gene id: 686340:METAL_RS07025
uniprot id: H8GKQ6
names: Similarity
messages: Belongs to the peptidase U62 family.

686340:METAL RS18465
gene id: 686340:METAL_RS18465
uniprot id: H8GID5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

686340:METAL RS13035
gene id: 686340:METAL_RS13035
uniprot id: H8GKA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

686340:METAL RS01590
gene id: 686340:METAL_RS01590
uniprot id: H8GLY9
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

686340:METAL RS11060
gene id: 686340:METAL_RS11060
uniprot id: H8GGQ5
names: Similarity
messages: Belongs to the P(II) protein family.

686340:METAL RS16170
gene id: 686340:METAL_RS16170
uniprot id: H8GQ59
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

686340:METAL RS17885
gene id: 686340:METAL_RS17885
uniprot id: H8GHL2
names: Similarity
messages: Belongs to the elongation factor P family.

686340:METAL RS00340
gene id: 686340:METAL_RS00340
uniprot id: H8GJY1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: Homotrimer.

686340:METAL RS00515
gene id: 686340:METAL_RS00515
uniprot id: H8GK18
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

686340:METAL RS17135
gene id: 686340:METAL_RS17135
uniprot id: H8GGA1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

686340:METAL RS12485
gene id: 686340:METAL_RS12485
uniprot id: H8GIU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

686340:METAL RS14595
gene id: 686340:METAL_RS14595
uniprot id: H8GMH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

686340:METAL RS11870
gene id: 686340:METAL_RS11870
uniprot id: H8GI26
names: Similarity
messages: Belongs to the transposase 7 family.

686340:METAL RS04475
gene id: 686340:METAL_RS04475
uniprot id: H8GFY5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

686340:METAL RS17780
gene id: 686340:METAL_RS17780
uniprot id: H8GH34
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

686340:METAL RS09370
gene id: 686340:METAL_RS09370
uniprot id: H8GPB1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

686340:METAL RS08435
gene id: 686340:METAL_RS08435
uniprot id: H8GMV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell inner membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

686340:METAL RS07115
gene id: 686340:METAL_RS07115
uniprot id: H8GKS4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS14630
gene id: 686340:METAL_RS14630
uniprot id: H8GMY9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

686340:METAL RS00695
gene id: 686340:METAL_RS00695
uniprot id: H8GKK2
names: Similarity
messages: Belongs to the skp family.

686340:METAL RS11240
gene id: 686340:METAL_RS11240
uniprot id: H8GGU0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase S45 family.
messages: Binds 1 Ca(2+) ion per dimer.

686340:METAL RS12200
gene id: 686340:METAL_RS12200
uniprot id: H8GI88
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

686340:METAL RS05380
gene id: 686340:METAL_RS05380
uniprot id: H8GHC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

686340:METAL RS11050
gene id: 686340:METAL_RS11050
uniprot id: H8GGQ3
names: Similarity
messages: Belongs to the P(II) protein family.

686340:METAL RS09115
gene id: 686340:METAL_RS09115
uniprot id: H8GP58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. AlkB subfamily.
messages: Cell inner membrane
messages: Membrane

686340:METAL RS01275
gene id: 686340:METAL_RS01275
uniprot id: H8GLC4
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).

686340:METAL RS07885
gene id: 686340:METAL_RS07885
uniprot id: H8GM39
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

686340:METAL RS13710
gene id: 686340:METAL_RS13710
uniprot id: H8GL43
names: Similarity
messages: Belongs to the peptidase M1 family.

686340:METAL RS11980
gene id: 686340:METAL_RS11980
uniprot id: H8GI46
names: PTM
messages: Binds 1 heme c group covalently per subunit.

686340:METAL RS02280
gene id: 686340:METAL_RS02280
uniprot id: H8GN88
names: Similarity
messages: Belongs to the YicC/YloC family.

686340:METAL RS10845
gene id: 686340:METAL_RS10845
uniprot id: H8GG56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

686340:METAL RS11785
gene id: 686340:METAL_RS11785
uniprot id: H8GHK2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

686340:METAL RS07220
gene id: 686340:METAL_RS07220
uniprot id: H8GKU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

686340:METAL RS13005
gene id: 686340:METAL_RS13005
uniprot id: H8GJN2
names: Similarity
messages: Belongs to the peptidase S41A family.

686340:METAL RS07385
gene id: 686340:METAL_RS07385
uniprot id: H8GKX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

686340:METAL RS18030
gene id: 686340:METAL_RS18030
uniprot id: H8GHP1
names: Similarity
messages: Belongs to the GSP E family.

686340:METAL RS14380
gene id: 686340:METAL_RS14380
uniprot id: H8GMC9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

686340:METAL RS05635
gene id: 686340:METAL_RS05635
uniprot id: H8GKC5
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

686340:METAL RS05725
gene id: 686340:METAL_RS05725
uniprot id: H8GHZ0
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

686340:METAL RS08300
gene id: 686340:METAL_RS08300
uniprot id: H8GMS3
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

686340:METAL RS13595
gene id: 686340:METAL_RS13595
uniprot id: H8GL22
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

686340:METAL RS12300
gene id: 686340:METAL_RS12300
uniprot id: H8GIR2
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

686340:METAL RS16085
gene id: 686340:METAL_RS16085
uniprot id: H8GQ47
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

686340:METAL RS01095
gene id: 686340:METAL_RS01095
uniprot id: H8GL88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

686340:METAL RS17525
gene id: 686340:METAL_RS17525
uniprot id: H8GKC5
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

686340:METAL RS18730
gene id: 686340:METAL_RS18730
uniprot id: H8GIZ3
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

686340:METAL RS05995
gene id: 686340:METAL_RS05995
uniprot id: H8GIK1
names: Function
names: Similarity
messages: Belongs to the cyanase family.
messages: Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.

686340:METAL RS05680
gene id: 686340:METAL_RS05680
uniprot id: H8GHY1
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

686340:METAL RS03440
gene id: 686340:METAL_RS03440
uniprot id: H8GQ80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

686340:METAL RS12495
gene id: 686340:METAL_RS12495
uniprot id: H8GIV0
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

686340:METAL RS19895
gene id: 686340:METAL_RS19895
uniprot id: H8GM80
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS15855
gene id: 686340:METAL_RS15855
uniprot id: H8GQ00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

686340:METAL RS10170
gene id: 686340:METAL_RS10170
uniprot id: H8GQM6
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

686340:METAL RS00305
gene id: 686340:METAL_RS00305
uniprot id: H8GJX4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbD subfamily.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.

686340:METAL RS04130
gene id: 686340:METAL_RS04130
uniprot id: H8GR10
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. PqqE family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).
messages: Interacts with PqqD. The interaction is necessary for activity of PqqE.

686340:METAL RS01280
gene id: 686340:METAL_RS01280
uniprot id: H8GLC5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

686340:METAL RS16045
gene id: 686340:METAL_RS16045
uniprot id: H8GQ39
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

686340:METAL RS07200
gene id: 686340:METAL_RS07200
uniprot id: H8GKU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

686340:METAL RS06960
gene id: 686340:METAL_RS06960
uniprot id: H8GK91
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).

686340:METAL RS11405
gene id: 686340:METAL_RS11405
uniprot id: H8GGW9
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS01180
gene id: 686340:METAL_RS01180
uniprot id: H8GLA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate.
messages: Homotetramer.

686340:METAL RS12290
gene id: 686340:METAL_RS12290
uniprot id: H8GIR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

686340:METAL RS12125
gene id: 686340:METAL_RS12125
uniprot id: H8GI75
names: Similarity
messages: Belongs to the Nudix hydrolase family.

686340:METAL RS10885
gene id: 686340:METAL_RS10885
uniprot id: H8GG63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane

686340:METAL RS11070
gene id: 686340:METAL_RS11070
uniprot id: H8GGQ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

686340:METAL RS12170
gene id: 686340:METAL_RS12170
uniprot id: H8GI82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell inner membrane
messages: Membrane

686340:METAL RS08370
gene id: 686340:METAL_RS08370
uniprot id: H8GMT9
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS08660
gene id: 686340:METAL_RS08660
uniprot id: H8GNF8
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

686340:METAL RS06935
gene id: 686340:METAL_RS06935
uniprot id: H8GK86
names: Similarity
messages: Belongs to the YoeB family.

686340:METAL RS00685
gene id: 686340:METAL_RS00685
uniprot id: H8GKK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

686340:METAL RS10425
gene id: 686340:METAL_RS10425
uniprot id: H8GR74
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

686340:METAL RS13205
gene id: 686340:METAL_RS13205
uniprot id: H8GKD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane
messages: Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.

686340:METAL RS19550
gene id: 686340:METAL_RS19550
uniprot id: H8GRK8
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

686340:METAL RS18290
gene id: 686340:METAL_RS18290
uniprot id: H8GIA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

686340:METAL RS03655
gene id: 686340:METAL_RS03655
uniprot id: H8GQB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm

686340:METAL RS11620
gene id: 686340:METAL_RS11620
uniprot id: H8GHH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptE lipoprotein family.
messages: Cell outer membrane
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptD.
messages: Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.

686340:METAL RS00330
gene id: 686340:METAL_RS00330
uniprot id: H8GJX9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

686340:METAL RS01060
gene id: 686340:METAL_RS01060
uniprot id: H8GL83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Mediates magnesium influx to the cytosol.
messages: Membrane

686340:METAL RS04445
gene id: 686340:METAL_RS04445
uniprot id: H8GFX9
names: Similarity
names: Subunit
messages: Belongs to the MoaE family.
messages: Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis.

686340:METAL RS15960
gene id: 686340:METAL_RS15960
uniprot id: H8GQ21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

686340:METAL RS19575
gene id: 686340:METAL_RS19575
uniprot id: H8GRL3
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

686340:METAL RS16210
gene id: 686340:METAL_RS16210
uniprot id: H8GKC5
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

686340:METAL RS04465
gene id: 686340:METAL_RS04465
uniprot id: H8GFY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

686340:METAL RS17090
gene id: 686340:METAL_RS17090
uniprot id: H8GG92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT.
messages: Cytoplasm

686340:METAL RS07510
gene id: 686340:METAL_RS07510
uniprot id: H8GLG0
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

686340:METAL RS14260
gene id: 686340:METAL_RS14260
uniprot id: H8GMA6
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS12870
gene id: 686340:METAL_RS12870
uniprot id: H8GJK6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS09375
gene id: 686340:METAL_RS09375
uniprot id: H8GPB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane

686340:METAL RS03745
gene id: 686340:METAL_RS03745
uniprot id: H8GQD6
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

686340:METAL RS17595
gene id: 686340:METAL_RS17595
uniprot id: H8GGZ7
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS18670
gene id: 686340:METAL_RS18670
uniprot id: H8GKC5
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

686340:METAL RS18705
gene id: 686340:METAL_RS18705
uniprot id: H8GIY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MerT family.
messages: Cell inner membrane
messages: Membrane

686340:METAL RS16150
gene id: 686340:METAL_RS16150
uniprot id: H8GQ56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

686340:METAL RS00650
gene id: 686340:METAL_RS00650
uniprot id: H8GKJ4
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.

686340:METAL RS04625
gene id: 686340:METAL_RS04625
uniprot id: H8GGG9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

686340:METAL RS21270
gene id: 686340:METAL_RS21270
uniprot id: H8GHS4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

686340:METAL RS13215
gene id: 686340:METAL_RS13215
uniprot id: H8GKE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

686340:METAL RS14500
gene id: 686340:METAL_RS14500
uniprot id: H8GMF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

686340:METAL RS11015
gene id: 686340:METAL_RS11015
uniprot id: H8GGP6
names: Similarity
names: Subunit
messages: Belongs to the Ahb/Nir family.
messages: Probably forms a complex composed of NirD, NirL, NirG and NirH. All proteins are required for the total conversion of siroheme to didecarboxysiroheme.

686340:METAL RS18515
gene id: 686340:METAL_RS18515
uniprot id: H8GIE3
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

686340:METAL RS07895
gene id: 686340:METAL_RS07895
uniprot id: H8GM41
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

686340:METAL RS13795
gene id: 686340:METAL_RS13795
uniprot id: H8GL59
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

686340:METAL RS05205
gene id: 686340:METAL_RS05205
uniprot id: H8GH87
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

686340:METAL RS11790
gene id: 686340:METAL_RS11790
uniprot id: H8GHK3
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

686340:METAL RS02215
gene id: 686340:METAL_RS02215
uniprot id: H8GN77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

686340:METAL RS08685
gene id: 686340:METAL_RS08685
uniprot id: H8GNG3
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

686340:METAL RS06860
gene id: 686340:METAL_RS06860
uniprot id: H8GK71
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

686340:METAL RS02505
gene id: 686340:METAL_RS02505
uniprot id: H8GND2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

686340:METAL RS17820
gene id: 686340:METAL_RS17820
uniprot id: H8GH42
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

686340:METAL RS16765
gene id: 686340:METAL_RS16765
uniprot id: H8GRC9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

686340:METAL RS04230
gene id: 686340:METAL_RS04230
uniprot id: H8GFU0
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
messages: Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the cytidylyltransferase family.
messages: In the N-terminal section; belongs to the carbohydrate kinase PfkB family.

686340:METAL RS09410
gene id: 686340:METAL_RS09410
uniprot id: H8GPS6
names: Similarity
messages: Belongs to the YfgM family.

686340:METAL RS16020
gene id: 686340:METAL_RS16020
uniprot id: H8GQ33
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

686340:METAL RS15415
gene id: 686340:METAL_RS15415
uniprot id: H8GNU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family. ParE type 1 subfamily.
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

686340:METAL RS15030
gene id: 686340:METAL_RS15030
uniprot id: H8GN65
names: Similarity
messages: Belongs to the ClpA/ClpB family.

686340:METAL RS10860
gene id: 686340:METAL_RS10860
uniprot id: H8GG59
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

686340:METAL RS14555
gene id: 686340:METAL_RS14555
uniprot id: H8GMG3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
messages: Cell membrane
messages: Heterodimer of a large and a small subunit.

686340:METAL RS12455
gene id: 686340:METAL_RS12455
uniprot id: H8GIU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
messages: Cell inner membrane

686340:METAL RS14775
gene id: 686340:METAL_RS14775
uniprot id: H8GN18
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NqrA family.
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

686340:METAL RS14385
gene id: 686340:METAL_RS14385
uniprot id: H8GMD0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

686340:METAL RS14410
gene id: 686340:METAL_RS14410
uniprot id: H8GMD5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

686340:METAL RS01715
gene id: 686340:METAL_RS01715
uniprot id: H8GM12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

686340:METAL RS11180
gene id: 686340:METAL_RS11180
uniprot id: H8GGS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane

686340:METAL RS03690
gene id: 686340:METAL_RS03690
uniprot id: H8GQC5
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

686340:METAL RS18340
gene id: 686340:METAL_RS18340
uniprot id: H8GIB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

686340:METAL RS08235
gene id: 686340:METAL_RS08235
uniprot id: H8GMQ9
names: Similarity
messages: Belongs to the HSP15 family.

686340:METAL RS16745
gene id: 686340:METAL_RS16745
uniprot id: H8GRC4
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

686340:METAL RS12115
gene id: 686340:METAL_RS12115
uniprot id: H8GI73
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

686340:METAL RS14370
gene id: 686340:METAL_RS14370
uniprot id: H8GMC7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

686340:METAL RS11770
gene id: 686340:METAL_RS11770
uniprot id: H8GHJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

686340:METAL RS01350
gene id: 686340:METAL_RS01350
uniprot id: H8GLD9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

686340:METAL RS11105
gene id: 686340:METAL_RS11105
uniprot id: H8GGR1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

686340:METAL RS06610
gene id: 686340:METAL_RS06610
uniprot id: H8GJF5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

686340:METAL RS17215
gene id: 686340:METAL_RS17215
uniprot id: H8GGB7
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

686340:METAL RS10035
gene id: 686340:METAL_RS10035
uniprot id: H8GQJ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

686340:METAL RS05115
gene id: 686340:METAL_RS05115
uniprot id: H8GH70
names: Similarity
messages: Belongs to the Nudix hydrolase family.

686340:METAL RS04160
gene id: 686340:METAL_RS04160
uniprot id: H8GR17
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.

686340:METAL RS12305
gene id: 686340:METAL_RS12305
uniprot id: H8GIR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiJ family.
messages: Cytoplasm
messages: Required for ubiquinone (coenzyme Q) biosynthesis. Binds hydrophobic ubiquinone biosynthetic intermediates via its SCP2 domain and is essential for the stability of the Ubi complex. May constitute a docking platform where Ubi enzymes assemble and access their SCP2-bound polyprenyl substrates.

686340:METAL RS07535
gene id: 686340:METAL_RS07535
uniprot id: H8GLG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

686340:METAL RS00290
gene id: 686340:METAL_RS00290
uniprot id: H8GJX1
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

686340:METAL RS11025
gene id: 686340:METAL_RS11025
uniprot id: H8GGP8
names: Similarity
names: Subunit
messages: Belongs to the Ahb/Nir family.
messages: Probably forms a complex composed of NirD, NirL, NirG and NirH. All proteins are required for the total conversion of siroheme to didecarboxysiroheme.

686340:METAL RS09925
gene id: 686340:METAL_RS09925
uniprot id: H8GQH6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

686340:METAL RS18780
gene id: 686340:METAL_RS18780
uniprot id: H8GJ01
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmD family.
messages: Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle.

686340:METAL RS06805
gene id: 686340:METAL_RS06805
uniprot id: H8GK61
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

686340:METAL RS11650
gene id: 686340:METAL_RS11650
uniprot id: H8GHH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

686340:METAL RS06720
gene id: 686340:METAL_RS06720
uniprot id: H8GK44
names: Cofactor
names: Similarity
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.

686340:METAL RS05820
gene id: 686340:METAL_RS05820
uniprot id: H8GI09
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

686340:METAL RS11175
gene id: 686340:METAL_RS11175
uniprot id: H8GGS7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

686340:METAL RS04500
gene id: 686340:METAL_RS04500
uniprot id: H8GFZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane

686340:METAL RS10830
gene id: 686340:METAL_RS10830
uniprot id: H8GKC5
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

686340:METAL RS09740
gene id: 686340:METAL_RS09740
uniprot id: H8GPZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

686340:METAL RS14730
gene id: 686340:METAL_RS14730
uniprot id: H8GN09
names: Cofactor
messages: Binds 2 Mg(2+) ions per monomer.

686340:METAL RS17965
gene id: 686340:METAL_RS17965
uniprot id: H8GHM8
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

686340:METAL RS14725
gene id: 686340:METAL_RS14725
uniprot id: H8GN08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Cell inner membrane
messages: Membrane

686340:METAL RS06730
gene id: 686340:METAL_RS06730
uniprot id: H8GK46
names: Similarity
messages: Belongs to the CFA/CMAS family.

686340:METAL RS12080
gene id: 686340:METAL_RS12080
uniprot id: H8GI66
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

686340:METAL RS04970
gene id: 686340:METAL_RS04970
uniprot id: H8GGN7
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

686340:METAL RS12330
gene id: 686340:METAL_RS12330
uniprot id: H8GIR9
names: Similarity
messages: Belongs to the YjdM family.

686340:METAL RS16120
gene id: 686340:METAL_RS16120
uniprot id: H8GQ54
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS14540
gene id: 686340:METAL_RS14540
uniprot id: H8GMG0
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

686340:METAL RS07865
gene id: 686340:METAL_RS07865
uniprot id: H8GM35
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

686340:METAL RS06760
gene id: 686340:METAL_RS06760
uniprot id: H8GK52
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

686340:METAL RS16670
gene id: 686340:METAL_RS16670
uniprot id: H8GRA9
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

686340:METAL RS13440
gene id: 686340:METAL_RS13440
uniprot id: H8GKZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

686340:METAL RS07750
gene id: 686340:METAL_RS07750
uniprot id: H8GLK9
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

686340:METAL RS14965
gene id: 686340:METAL_RS14965
uniprot id: H8GN53
names: Similarity
messages: Belongs to the VgrG protein family.

686340:METAL RS01825
gene id: 686340:METAL_RS01825
uniprot id: H8GMI8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

686340:METAL RS10395
gene id: 686340:METAL_RS10395
uniprot id: H8GR68
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

686340:METAL RS09005
gene id: 686340:METAL_RS09005
uniprot id: H8GP35
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

686340:METAL RS18025
gene id: 686340:METAL_RS18025
uniprot id: H8GHP0
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

686340:METAL RS04795
gene id: 686340:METAL_RS04795
uniprot id: H8GGK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

686340:METAL RS12760
gene id: 686340:METAL_RS12760
uniprot id: H8GJI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase D family.
messages: Cytoplasm
messages: Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides.

686340:METAL RS01415
gene id: 686340:METAL_RS01415
uniprot id: H8GLV6
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS15475
gene id: 686340:METAL_RS15475
uniprot id: H8GPB8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

686340:METAL RS16970
gene id: 686340:METAL_RS16970
uniprot id: H8GRG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsQ/DivIB family. FtsQ subfamily.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

686340:METAL RS08200
gene id: 686340:METAL_RS08200
uniprot id: H8GM92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

686340:METAL RS02330
gene id: 686340:METAL_RS02330
uniprot id: H8GN98
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

686340:METAL RS19200
gene id: 686340:METAL_RS19200
uniprot id: H8GJQ7
names: Similarity
messages: Belongs to the MEMO1 family.

686340:METAL RS03430
gene id: 686340:METAL_RS03430
uniprot id: H8GQ78
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

686340:METAL RS09100
gene id: 686340:METAL_RS09100
uniprot id: H8GP55
names: Function
names: Similarity
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.

686340:METAL RS10030
gene id: 686340:METAL_RS10030
uniprot id: H8GQJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.

686340:METAL RS08650
gene id: 686340:METAL_RS08650
uniprot id: H8GNF6
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

686340:METAL RS12310
gene id: 686340:METAL_RS12310
uniprot id: H8GIR4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC1 family. UbiB subfamily.
messages: Cell membrane
messages: Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS00955
gene id: 686340:METAL_RS00955
uniprot id: H8GKQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

686340:METAL RS09585
gene id: 686340:METAL_RS09585
uniprot id: H8GPW3
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

686340:METAL RS08565
gene id: 686340:METAL_RS08565
uniprot id: H8GMX9
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

686340:METAL RS07000
gene id: 686340:METAL_RS07000
uniprot id: H8GK99
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

686340:METAL RS13315
gene id: 686340:METAL_RS13315
uniprot id: H8GKG0
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

686340:METAL RS09665
gene id: 686340:METAL_RS09665
uniprot id: H8GPX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

686340:METAL RS01750
gene id: 686340:METAL_RS01750
uniprot id: H8GM19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

686340:METAL RS15380
gene id: 686340:METAL_RS15380
uniprot id: H8GNT9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.

686340:METAL RS05405
gene id: 686340:METAL_RS05405
uniprot id: H8GHC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

686340:METAL RS15385
gene id: 686340:METAL_RS15385
uniprot id: H8GNU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

686340:METAL RS07910
gene id: 686340:METAL_RS07910
uniprot id: H8GM44
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS15320
gene id: 686340:METAL_RS15320
uniprot id: H8GNS8
names: Similarity
messages: Belongs to the PhzF family.

686340:METAL RS16235
gene id: 686340:METAL_RS16235
uniprot id: H8GQ73
names: Similarity
messages: Belongs to the peptidase S16 family.

686340:METAL RS14520
gene id: 686340:METAL_RS14520
uniprot id: H8GMF6
names: Similarity
messages: Belongs to the BolA/IbaG family.

686340:METAL RS11590
gene id: 686340:METAL_RS11590
uniprot id: H8GHG4
names: Similarity
messages: Belongs to the acylphosphatase family.

686340:METAL RS13520
gene id: 686340:METAL_RS13520
uniprot id: H8GL08
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

686340:METAL RS08675
gene id: 686340:METAL_RS08675
uniprot id: H8GNG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgI family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

686340:METAL RS17755
gene id: 686340:METAL_RS17755
uniprot id: H8GH29
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

686340:METAL RS17070
gene id: 686340:METAL_RS17070
uniprot id: H8GG88
names: Similarity
messages: Belongs to the HisA/HisF family.

686340:METAL RS04965
gene id: 686340:METAL_RS04965
uniprot id: H8GGN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Heterodimer of an alpha and a beta chain.
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

686340:METAL RS11705
gene id: 686340:METAL_RS11705
uniprot id: H8GHI7
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

686340:METAL RS03675
gene id: 686340:METAL_RS03675
uniprot id: H8GQC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

686340:METAL RS00255
gene id: 686340:METAL_RS00255
uniprot id: H8GJW4
names: Function
names: Similarity
messages: Belongs to the Dus family. DusB subfamily.
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

686340:METAL RS09835
gene id: 686340:METAL_RS09835
uniprot id: H8GQG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

686340:METAL RS02250
gene id: 686340:METAL_RS02250
uniprot id: H8GN83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

686340:METAL RS01855
gene id: 686340:METAL_RS01855
uniprot id: H8GMJ4
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

686340:METAL RS07110
gene id: 686340:METAL_RS07110
uniprot id: H8GKS3
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

686340:METAL RS01405
gene id: 686340:METAL_RS01405
uniprot id: H8GLV3
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.

686340:METAL RS06500
gene id: 686340:METAL_RS06500
uniprot id: H8GJD9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

686340:METAL RS03710
gene id: 686340:METAL_RS03710
uniprot id: H8GQC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

686340:METAL RS13095
gene id: 686340:METAL_RS13095
uniprot id: H8GKB8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. UvrD subfamily.
messages: Homodimer.
messages: Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.

686340:METAL RS03730
gene id: 686340:METAL_RS03730
uniprot id: H8GQD3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

686340:METAL RS16680
gene id: 686340:METAL_RS16680
uniprot id: H8GRB1
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

686340:METAL RS19700
gene id: 686340:METAL_RS19700
uniprot id: H8GLX7
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

686340:METAL RS01355
gene id: 686340:METAL_RS01355
uniprot id: H8GLE0
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

686340:METAL RS11595
gene id: 686340:METAL_RS11595
uniprot id: H8GHG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell membrane
messages: Membrane

686340:METAL RS08295
gene id: 686340:METAL_RS08295
uniprot id: H8GMS2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

686340:METAL RS01310
gene id: 686340:METAL_RS01310
uniprot id: H8GLD1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

686340:METAL RS07875
gene id: 686340:METAL_RS07875
uniprot id: H8GM37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

686340:METAL RS00020
gene id: 686340:METAL_RS00020
uniprot id: H8GJ60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

686340:METAL RS00010
gene id: 686340:METAL_RS00010
uniprot id: H8GJ57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

686340:METAL RS17035
gene id: 686340:METAL_RS17035
uniprot id: H8GRI2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

686340:METAL RS01760
gene id: 686340:METAL_RS01760
uniprot id: H8GM21
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

686340:METAL RS08740
gene id: 686340:METAL_RS08740
uniprot id: H8GNH4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
messages: Heterodimer composed of CysD, the smaller subunit, and CysN.
messages: With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

686340:METAL RS11080
gene id: 686340:METAL_RS11080
uniprot id: H8GGQ9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.

686340:METAL RS01165
gene id: 686340:METAL_RS01165
uniprot id: H8GLA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute-binding proteins (MlaB) and six periplasmic solute-binding proteins (MlaD).

686340:METAL RS03405
gene id: 686340:METAL_RS03405
uniprot id: H8GQ74
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

686340:METAL RS10585
gene id: 686340:METAL_RS10585
uniprot id: H8GRA3
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

686340:METAL RS14250
gene id: 686340:METAL_RS14250
uniprot id: H8GMA4
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS04270
gene id: 686340:METAL_RS04270
uniprot id: H8GFU3
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

686340:METAL RS08705
gene id: 686340:METAL_RS08705
uniprot id: H8GNG7
names: Similarity
messages: Belongs to the MotB family.

686340:METAL RS03740
gene id: 686340:METAL_RS03740
uniprot id: H8GQD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

686340:METAL RS07085
gene id: 686340:METAL_RS07085
uniprot id: H8GKR8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Monomer.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

686340:METAL RS10275
gene id: 686340:METAL_RS10275
uniprot id: H8GR45
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

686340:METAL RS14120
gene id: 686340:METAL_RS14120
uniprot id: H8GLS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

686340:METAL RS18850
gene id: 686340:METAL_RS18850
uniprot id: H8GHF3
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

686340:METAL RS14755
gene id: 686340:METAL_RS14755
uniprot id: H8GN14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

686340:METAL RS16055
gene id: 686340:METAL_RS16055
uniprot id: H8GQ41
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Methylated by PrmB.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

686340:METAL RS16000
gene id: 686340:METAL_RS16000
uniprot id: H8GQ29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

686340:METAL RS18365
gene id: 686340:METAL_RS18365
uniprot id: H8GIB5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 3 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

686340:METAL RS06360
gene id: 686340:METAL_RS06360
uniprot id: H8GQY6
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

686340:METAL RS01090
gene id: 686340:METAL_RS01090
uniprot id: H8GL87
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CopD family.
messages: Cell inner membrane
messages: Involved in copper resistance.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

686340:METAL RS16985
gene id: 686340:METAL_RS16985
uniprot id: H8GRH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

686340:METAL RS09295
gene id: 686340:METAL_RS09295
uniprot id: H8GP96
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

686340:METAL RS19595
gene id: 686340:METAL_RS19595
uniprot id: H8GRL6
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

686340:METAL RS14175
gene id: 686340:METAL_RS14175
uniprot id: H8GLT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

686340:METAL RS16815
gene id: 686340:METAL_RS16815
uniprot id: H8GRD9
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

686340:METAL RS13635
gene id: 686340:METAL_RS13635
uniprot id: H8GL30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Pal lipoprotein family.
messages: Cell outer membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

686340:METAL RS07595
gene id: 686340:METAL_RS07595
uniprot id: H8GLH6
names: Cofactor
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

686340:METAL RS09085
gene id: 686340:METAL_RS09085
uniprot id: H8GP51
names: Similarity
messages: Belongs to the PhoH family.

686340:METAL RS05415
gene id: 686340:METAL_RS05415
uniprot id: H8GHC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

686340:METAL RS05910
gene id: 686340:METAL_RS05910
uniprot id: H8GII4
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

686340:METAL RS06425
gene id: 686340:METAL_RS06425
uniprot id: H8GJC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

686340:METAL RS01815
gene id: 686340:METAL_RS01815
uniprot id: H8GMI6
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

686340:METAL RS04925
gene id: 686340:METAL_RS04925
uniprot id: H8GGM8
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

686340:METAL RS08655
gene id: 686340:METAL_RS08655
uniprot id: H8GNF7
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

686340:METAL RS01745
gene id: 686340:METAL_RS01745
uniprot id: H8GM18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

686340:METAL RS18785
gene id: 686340:METAL_RS18785
uniprot id: H8GJ02
names: Similarity
messages: Belongs to the peptidase M16 family.

686340:METAL RS04780
gene id: 686340:METAL_RS04780
uniprot id: H8GGJ9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

686340:METAL RS05700
gene id: 686340:METAL_RS05700
uniprot id: H8GHY5
names: Similarity
messages: Belongs to the peptidase A31 family.

686340:METAL RS15340
gene id: 686340:METAL_RS15340
uniprot id: H8GNT2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

686340:METAL RS09020
gene id: 686340:METAL_RS09020
uniprot id: H8GP38
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

686340:METAL RS12825
gene id: 686340:METAL_RS12825
uniprot id: H8GJK0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

686340:METAL RS16580
gene id: 686340:METAL_RS16580
uniprot id: H8GQT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

686340:METAL RS16725
gene id: 686340:METAL_RS16725
uniprot id: H8GRC0
names: Function
names: Similarity
messages: Belongs to the Fe(2+)-trafficking protein family.
messages: Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.

686340:METAL RS18085
gene id: 686340:METAL_RS18085
uniprot id: H8GHQ3
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.
messages: Belongs to the RecC family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

686340:METAL RS13750
gene id: 686340:METAL_RS13750
uniprot id: H8GL51
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

686340:METAL RS04300
gene id: 686340:METAL_RS04300
uniprot id: H8GFU9
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS04975
gene id: 686340:METAL_RS04975
uniprot id: H8GGN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.
messages: Cytoplasm
messages: Specifically methylates the ribose of guanosine 2251 in 23S rRNA.

686340:METAL RS19395
gene id: 686340:METAL_RS19395
uniprot id: H8GJU1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS05940
gene id: 686340:METAL_RS05940
uniprot id: H8GIJ0
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

686340:METAL RS12750
gene id: 686340:METAL_RS12750
uniprot id: H8GJI7
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
messages: Periplasm
messages: The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition.

686340:METAL RS19065
gene id: 686340:METAL_RS19065
uniprot id: H8GJN5
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

686340:METAL RS02695
gene id: 686340:METAL_RS02695
uniprot id: H8GNX4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

686340:METAL RS02385
gene id: 686340:METAL_RS02385
uniprot id: H8GNA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

686340:METAL RS02100
gene id: 686340:METAL_RS02100
uniprot id: H8GMP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

686340:METAL RS18980
gene id: 686340:METAL_RS18980
uniprot id: H8GJ40
names: Similarity
messages: Belongs to the SsuE family.

686340:METAL RS02145
gene id: 686340:METAL_RS02145
uniprot id: H8GMQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

686340:METAL RS09530
gene id: 686340:METAL_RS09530
uniprot id: H8GPV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

686340:METAL RS05875
gene id: 686340:METAL_RS05875
uniprot id: H8GIH7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

686340:METAL RS03795
gene id: 686340:METAL_RS03795
uniprot id: H8GQE6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

686340:METAL RS15135
gene id: 686340:METAL_RS15135
uniprot id: H8GNP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

686340:METAL RS04220
gene id: 686340:METAL_RS04220
uniprot id: H8GFT8
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS06370
gene id: 686340:METAL_RS06370
uniprot id: H8GJB3
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

686340:METAL RS13600
gene id: 686340:METAL_RS13600
uniprot id: H8GL23
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

686340:METAL RS18775
gene id: 686340:METAL_RS18775
uniprot id: H8GJ00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

686340:METAL RS11130
gene id: 686340:METAL_RS11130
uniprot id: H8GGR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISPR system Cmr5 family.
messages: Cytoplasm

686340:METAL RS08345
gene id: 686340:METAL_RS08345
uniprot id: H8GMT3
names: Similarity
messages: Belongs to the WrbA family.

686340:METAL RS04235
gene id: 686340:METAL_RS04235
uniprot id: H8GFU1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
messages: Binds 1 NADP(+) per subunit.
messages: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
messages: Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
messages: Homopentamer.

686340:METAL RS09955
gene id: 686340:METAL_RS09955
uniprot id: H8GQI2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS07570
gene id: 686340:METAL_RS07570
uniprot id: H8GLH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

686340:METAL RS17020
gene id: 686340:METAL_RS17020
uniprot id: H8GRH9
names: Function
names: Similarity
messages: Belongs to the transpeptidase family. FtsI subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.

686340:METAL RS02025
gene id: 686340:METAL_RS02025
uniprot id: H8GMM7
names: Similarity
messages: Belongs to the FwdC/FmdC family.

686340:METAL RS12830
gene id: 686340:METAL_RS12830
uniprot id: H8GJK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

686340:METAL RS17675
gene id: 686340:METAL_RS17675
uniprot id: H8GH12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

686340:METAL RS03815
gene id: 686340:METAL_RS03815
uniprot id: H8GQF0
names: Similarity
messages: Belongs to the transglycosylase Slt family.

686340:METAL RS09255
gene id: 686340:METAL_RS09255
uniprot id: H8GP88
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues, the fourth Fe has a free coordination site that may bind a sulfur atom transferred from the persulfide of IscS.
messages: Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
messages: Cytoplasm
messages: Homodimer.
messages: The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster.

686340:METAL RS17955
gene id: 686340:METAL_RS17955
uniprot id: H8GHM6
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

686340:METAL RS15505
gene id: 686340:METAL_RS15505
uniprot id: H8GPC3
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

686340:METAL RS02490
gene id: 686340:METAL_RS02490
uniprot id: H8GNC9
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

686340:METAL RS18305
gene id: 686340:METAL_RS18305
uniprot id: H8GIA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

686340:METAL RS16570
gene id: 686340:METAL_RS16570
uniprot id: H8GQT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

686340:METAL RS09825
gene id: 686340:METAL_RS09825
uniprot id: H8GKC5
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

686340:METAL RS06945
gene id: 686340:METAL_RS06945
uniprot id: H8GK88
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

686340:METAL RS17570
gene id: 686340:METAL_RS17570
uniprot id: H8GGZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

686340:METAL RS11020
gene id: 686340:METAL_RS11020
uniprot id: H8GGP7
names: Similarity
names: Subunit
messages: Belongs to the Ahb/Nir family.
messages: Probably forms a complex composed of NirD, NirL, NirG and NirH. All proteins are required for the total conversion of siroheme to didecarboxysiroheme.

686340:METAL RS09875
gene id: 686340:METAL_RS09875
uniprot id: H8GQG7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS08590
gene id: 686340:METAL_RS08590
uniprot id: H8GMY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

686340:METAL RS05345
gene id: 686340:METAL_RS05345
uniprot id: H8GHB5
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

686340:METAL RS14305
gene id: 686340:METAL_RS14305
uniprot id: H8GMB5
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily.
messages: Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.

686340:METAL RS07380
gene id: 686340:METAL_RS07380
uniprot id: H8GKX6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

686340:METAL RS06390
gene id: 686340:METAL_RS06390
uniprot id: H8GJB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

686340:METAL RS10390
gene id: 686340:METAL_RS10390
uniprot id: H8GR67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

686340:METAL RS12865
gene id: 686340:METAL_RS12865
uniprot id: H8GJK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

686340:METAL RS06885
gene id: 686340:METAL_RS06885
uniprot id: H8GK76
names: Similarity
messages: Belongs to the glutamate synthase family.

686340:METAL RS09110
gene id: 686340:METAL_RS09110
uniprot id: H8GP57
names: Function
messages: DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.

686340:METAL RS01285
gene id: 686340:METAL_RS01285
uniprot id: H8GLC6
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

686340:METAL RS04415
gene id: 686340:METAL_RS04415
uniprot id: H8GFX3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

686340:METAL RS12635
gene id: 686340:METAL_RS12635
uniprot id: H8GJG5
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

686340:METAL RS10555
gene id: 686340:METAL_RS10555
uniprot id: H8GR97
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS02590
gene id: 686340:METAL_RS02590
uniprot id: H8GNV4
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS09450
gene id: 686340:METAL_RS09450
uniprot id: H8GPT4
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS05990
gene id: 686340:METAL_RS05990
uniprot id: H8GIK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.
messages: Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.
messages: Cytoplasm
messages: Homodimer.

686340:METAL RS05840
gene id: 686340:METAL_RS05840
uniprot id: H8GI13
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmJ family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the guanosine in position 1516 of 16S rRNA.

686340:METAL RS14390
gene id: 686340:METAL_RS14390
uniprot id: H8GMD1
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.

686340:METAL RS10705
gene id: 686340:METAL_RS10705
uniprot id: H8GG28
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

686340:METAL RS16770
gene id: 686340:METAL_RS16770
uniprot id: H8GRD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

686340:METAL RS08310
gene id: 686340:METAL_RS08310
uniprot id: H8GMS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

686340:METAL RS04855
gene id: 686340:METAL_RS04855
uniprot id: H8GGL4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

686340:METAL RS16665
gene id: 686340:METAL_RS16665
uniprot id: H8GRA8
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

686340:METAL RS11905
gene id: 686340:METAL_RS11905
uniprot id: H8GI32
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

686340:METAL RS04310
gene id: 686340:METAL_RS04310
uniprot id: H8GFV0
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS12910
gene id: 686340:METAL_RS12910
uniprot id: H8GJL4
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

686340:METAL RS09790
gene id: 686340:METAL_RS09790
uniprot id: H8GQF3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD.

686340:METAL RS15980
gene id: 686340:METAL_RS15980
uniprot id: H8GQ25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

686340:METAL RS02700
gene id: 686340:METAL_RS02700
uniprot id: H8GNX5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

686340:METAL RS04490
gene id: 686340:METAL_RS04490
uniprot id: H8GFY8
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

686340:METAL RS05555
gene id: 686340:METAL_RS05555
uniprot id: H8GHW2
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

686340:METAL RS02665
gene id: 686340:METAL_RS02665
uniprot id: H8GNW9
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

686340:METAL RS05300
gene id: 686340:METAL_RS05300
uniprot id: H8GHA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DksA family.
messages: Cytoplasm
messages: Interacts directly with the RNA polymerase.
messages: Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression.

686340:METAL RS04725
gene id: 686340:METAL_RS04725
uniprot id: H8GGI8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

686340:METAL RS18295
gene id: 686340:METAL_RS18295
uniprot id: H8GIA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

686340:METAL RS16500
gene id: 686340:METAL_RS16500
uniprot id: H8GQS7
names: Similarity
messages: Belongs to the heat shock protein 70 family.

686340:METAL RS16050
gene id: 686340:METAL_RS16050
uniprot id: H8GQ40
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

686340:METAL RS09440
gene id: 686340:METAL_RS09440
uniprot id: H8GPT2
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

686340:METAL RS16035
gene id: 686340:METAL_RS16035
uniprot id: H8GQ36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

686340:METAL RS09030
gene id: 686340:METAL_RS09030
uniprot id: H8GP40
names: Similarity
messages: Belongs to the ABC transporter superfamily.

686340:METAL RS14865
gene id: 686340:METAL_RS14865
uniprot id: H8GN36
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS11680
gene id: 686340:METAL_RS11680
uniprot id: H8GHI2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

686340:METAL RS06680
gene id: 686340:METAL_RS06680
uniprot id: H8GK35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

686340:METAL RS12500
gene id: 686340:METAL_RS12500
uniprot id: H8GIV1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein bS18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS05860
gene id: 686340:METAL_RS05860
uniprot id: H8GIH4
names: Function
names: Similarity
messages: Belongs to the MoaB/Mog family.
messages: May be involved in the biosynthesis of molybdopterin.

686340:METAL RS17860
gene id: 686340:METAL_RS17860
uniprot id: H8GH50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

686340:METAL RS16095
gene id: 686340:METAL_RS16095
uniprot id: H8GQ49
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

686340:METAL RS09570
gene id: 686340:METAL_RS09570
uniprot id: H8GPW0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS10215
gene id: 686340:METAL_RS10215
uniprot id: H8GR35
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS02540
gene id: 686340:METAL_RS02540
uniprot id: H8GND9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Membrane

686340:METAL RS13570
gene id: 686340:METAL_RS13570
uniprot id: H8GL17
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

686340:METAL RS01890
gene id: 686340:METAL_RS01890
uniprot id: H8GMK1
names: Similarity
messages: Belongs to the pirin family.

686340:METAL RS15800
gene id: 686340:METAL_RS15800
uniprot id: H8GPI3
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

686340:METAL RS18560
gene id: 686340:METAL_RS18560
uniprot id: H8GIF5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

686340:METAL RS00495
gene id: 686340:METAL_RS00495
uniprot id: H8GK14
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS08285
gene id: 686340:METAL_RS08285
uniprot id: H8GMS0
names: Similarity
messages: Belongs to the RutC family.

686340:METAL RS01335
gene id: 686340:METAL_RS01335
uniprot id: H8GLD6
names: Similarity
messages: Belongs to the Smg family.

686340:METAL RS04860
gene id: 686340:METAL_RS04860
uniprot id: H8GGL5
names: Similarity
messages: Belongs to the DEAD box helicase family.

686340:METAL RS09405
gene id: 686340:METAL_RS09405
uniprot id: H8GPS5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

686340:METAL RS14750
gene id: 686340:METAL_RS14750
uniprot id: H8GN13
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrF family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.

686340:METAL RS17465
gene id: 686340:METAL_RS17465
uniprot id: H8GGX2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).

686340:METAL RS12370
gene id: 686340:METAL_RS12370
uniprot id: H8GIS7
names: Function
names: Similarity
messages: Belongs to the ATPase gamma chain family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

686340:METAL RS00610
gene id: 686340:METAL_RS00610
uniprot id: H8GKI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. RhlB subfamily.
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA.

686340:METAL RS00710
gene id: 686340:METAL_RS00710
uniprot id: H8GKK5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation.
messages: May be beta-lysylated on the epsilon-amino group of Lys-34 by the combined action of EpmA and EpmB, and then hydroxylated on the C5 position of the same residue by EpmC (if this protein is present). Lysylation is critical for the stimulatory effect of EF-P on peptide-bond formation. The lysylation moiety may extend toward the peptidyltransferase center and stabilize the terminal 3-CCA end of the tRNA. Hydroxylation of the C5 position on Lys-34 may allow additional potential stabilizing hydrogen-bond interactions with the P-tRNA.

686340:METAL RS17470
gene id: 686340:METAL_RS17470
uniprot id: H8GGX3
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

686340:METAL RS09275
gene id: 686340:METAL_RS09275
uniprot id: H8GP92
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

686340:METAL RS09960
gene id: 686340:METAL_RS09960
uniprot id: H8GQI3
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

686340:METAL RS02485
gene id: 686340:METAL_RS02485
uniprot id: H8GNC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

686340:METAL RS01125
gene id: 686340:METAL_RS01125
uniprot id: H8GL94
names: Similarity
messages: Belongs to the UPF0166 family.

686340:METAL RS00440
gene id: 686340:METAL_RS00440
uniprot id: H8GK03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

686340:METAL RS00455
gene id: 686340:METAL_RS00455
uniprot id: H8GK06
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

686340:METAL RS07015
gene id: 686340:METAL_RS07015
uniprot id: H8GKA2
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

686340:METAL RS14525
gene id: 686340:METAL_RS14525
uniprot id: H8GMF7
names: Similarity
messages: Belongs to the YciI family.

686340:METAL RS16700
gene id: 686340:METAL_RS16700
uniprot id: H8GRB5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

686340:METAL RS11935
gene id: 686340:METAL_RS11935
uniprot id: H8GI36
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

686340:METAL RS07705
gene id: 686340:METAL_RS07705
uniprot id: H8GLK0
names: Similarity
messages: Belongs to the HepT RNase toxin family.

686340:METAL RS00310
gene id: 686340:METAL_RS00310
uniprot id: H8GJX5
names: Similarity
messages: Belongs to the CutA family.

686340:METAL RS07500
gene id: 686340:METAL_RS07500
uniprot id: H8GLF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

686340:METAL RS03060
gene id: 686340:METAL_RS03060
uniprot id: H8GPK5
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

686340:METAL RS18335
gene id: 686340:METAL_RS18335
uniprot id: H8GIA9
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

686340:METAL RS07660
gene id: 686340:METAL_RS07660
uniprot id: H8GLJ0
names: Similarity
messages: Belongs to the transposase 8 family.

686340:METAL RS12105
gene id: 686340:METAL_RS12105
uniprot id: H8GI71
names: Similarity
messages: Belongs to the GSP E family.

686340:METAL RS17980
gene id: 686340:METAL_RS17980
uniprot id: H8GHN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

686340:METAL RS08275
gene id: 686340:METAL_RS08275
uniprot id: H8GMR8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiC family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.

686340:METAL RS02170
gene id: 686340:METAL_RS02170
uniprot id: H8GN68
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoM family.
messages: Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS08465
gene id: 686340:METAL_RS08465
uniprot id: H8GMV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

686340:METAL RS13775
gene id: 686340:METAL_RS13775
uniprot id: H8GL56
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

686340:METAL RS19215
gene id: 686340:METAL_RS19215
uniprot id: H8GJR0
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

686340:METAL RS06440
gene id: 686340:METAL_RS06440
uniprot id: H8GJC7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

686340:METAL RS07295
gene id: 686340:METAL_RS07295
uniprot id: H8GKV9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

686340:METAL RS08715
gene id: 686340:METAL_RS08715
uniprot id: H8GNG9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

686340:METAL RS05510
gene id: 686340:METAL_RS05510
uniprot id: H8GHV4
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS09920
gene id: 686340:METAL_RS09920
uniprot id: H8GQH5
names: Similarity
messages: Belongs to the hemerythrin family.

686340:METAL RS04710
gene id: 686340:METAL_RS04710
uniprot id: H8GGI4
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

686340:METAL RS12140
gene id: 686340:METAL_RS12140
uniprot id: H8GI77
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA gyrase inhibitor YacG family.
messages: Binds 1 zinc ion.
messages: Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
messages: Interacts with GyrB.

686340:METAL RS09380
gene id: 686340:METAL_RS09380
uniprot id: H8GPB3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

686340:METAL RS07410
gene id: 686340:METAL_RS07410
uniprot id: H8GKY2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

686340:METAL RS15570
gene id: 686340:METAL_RS15570
uniprot id: H8GPD6
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS01480
gene id: 686340:METAL_RS01480
uniprot id: H8GLW8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

686340:METAL RS10325
gene id: 686340:METAL_RS10325
uniprot id: H8GR55
names: PTM
messages: Binds 2 heme c groups covalently per subunit.

686340:METAL RS15970
gene id: 686340:METAL_RS15970
uniprot id: H8GQ23
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

686340:METAL RS15425
gene id: 686340:METAL_RS15425
uniprot id: H8GNU8
names: Similarity
messages: Belongs to the MotB family.

686340:METAL RS15460
gene id: 686340:METAL_RS15460
uniprot id: H8GPB5
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

686340:METAL RS17300
gene id: 686340:METAL_RS17300
uniprot id: H8GGD4
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS05605
gene id: 686340:METAL_RS05605
uniprot id: H8GKC5
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

686340:METAL RS01870
gene id: 686340:METAL_RS01870
uniprot id: H8GMJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

686340:METAL RS11780
gene id: 686340:METAL_RS11780
uniprot id: H8GHK1
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

686340:METAL RS19205
gene id: 686340:METAL_RS19205
uniprot id: H8GJQ8
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

686340:METAL RS06685
gene id: 686340:METAL_RS06685
uniprot id: H8GK36
names: Similarity
messages: Belongs to the YggT family.

686340:METAL RS17870
gene id: 686340:METAL_RS17870
uniprot id: H8GHK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
messages: Cytoplasm
messages: Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).

686340:METAL RS16260
gene id: 686340:METAL_RS16260
uniprot id: H8GQN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

686340:METAL RS16955
gene id: 686340:METAL_RS16955
uniprot id: H8GRG6
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

686340:METAL RS18700
gene id: 686340:METAL_RS18700
uniprot id: H8GIY7
names: Function
messages: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury MerR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator, while remaining bound to the mer site.

686340:METAL RS14600
gene id: 686340:METAL_RS14600
uniprot id: H8GMH3
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS02580
gene id: 686340:METAL_RS02580
uniprot id: H8GNE5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Homodimer.

686340:METAL RS18310
gene id: 686340:METAL_RS18310
uniprot id: H8GIA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

686340:METAL RS00240
gene id: 686340:METAL_RS00240
uniprot id: H8GJW1
names: Similarity
messages: Belongs to the GARS family.

686340:METAL RS08750
gene id: 686340:METAL_RS08750
uniprot id: H8GNH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PAPS reductase family. CysD subfamily.
messages: Heterodimer composed of CysD, the smaller subunit, and CysN.
messages: With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

686340:METAL RS15390
gene id: 686340:METAL_RS15390
uniprot id: H8GNU1
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS00845
gene id: 686340:METAL_RS00845
uniprot id: H8GKN1
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

686340:METAL RS09805
gene id: 686340:METAL_RS09805
uniprot id: H8GQF6
names: Similarity
messages: Belongs to the SdhE FAD assembly factor family.

686340:METAL RS00620
gene id: 686340:METAL_RS00620
uniprot id: H8GKI8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS06575
gene id: 686340:METAL_RS06575
uniprot id: H8GJF3
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

686340:METAL RS16040
gene id: 686340:METAL_RS16040
uniprot id: H8GQ38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

686340:METAL RS03665
gene id: 686340:METAL_RS03665
uniprot id: H8GQC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

686340:METAL RS06040
gene id: 686340:METAL_RS06040
uniprot id: H8GIK7
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.

686340:METAL RS07240
gene id: 686340:METAL_RS07240
uniprot id: H8GKU9
names: Function
names: Similarity
messages: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
messages: Belongs to the Nudix hydrolase family. RppH subfamily.

686340:METAL RS04790
gene id: 686340:METAL_RS04790
uniprot id: H8GGK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

686340:METAL RS15820
gene id: 686340:METAL_RS15820
uniprot id: H8GPI7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

686340:METAL RS05285
gene id: 686340:METAL_RS05285
uniprot id: H8GHA2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

686340:METAL RS02535
gene id: 686340:METAL_RS02535
uniprot id: H8GND8
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS07855
gene id: 686340:METAL_RS07855
uniprot id: H8GM33
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

686340:METAL RS00025
gene id: 686340:METAL_RS00025
uniprot id: H8GJ61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

686340:METAL RS19160
gene id: 686340:METAL_RS19160
uniprot id: H8GJP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

686340:METAL RS19315
gene id: 686340:METAL_RS19315
uniprot id: H8GJS6
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS03460
gene id: 686340:METAL_RS03460
uniprot id: H8GQ84
names: Similarity
messages: Belongs to the tRNA(His) guanylyltransferase family.

686340:METAL RS00965
gene id: 686340:METAL_RS00965
uniprot id: H8GL64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.
messages: Cytoplasm
messages: Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity.

686340:METAL RS08445
gene id: 686340:METAL_RS08445
uniprot id: H8GMV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliN/MopA/SpaO family.
messages: Cell membrane
messages: FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

686340:METAL RS17715
gene id: 686340:METAL_RS17715
uniprot id: H8GH20
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

686340:METAL RS17910
gene id: 686340:METAL_RS17910
uniprot id: H8GHL7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

686340:METAL RS01800
gene id: 686340:METAL_RS01800
uniprot id: H8GMI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

686340:METAL RS04015
gene id: 686340:METAL_RS04015
uniprot id: H8GQY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

686340:METAL RS08630
gene id: 686340:METAL_RS08630
uniprot id: H8GNF2
names: Subcellular Location Annotation
messages: Cell inner membrane

686340:METAL RS12050
gene id: 686340:METAL_RS12050
uniprot id: H8GI60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

686340:METAL RS08570
gene id: 686340:METAL_RS08570
uniprot id: H8GMY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The M ring is integral to the inner membrane of the cell and may be connected to the flagellar rod via the S ring. The S (supramembrane ring) lies just distal to the M ring. The L and P rings lie in the outer membrane and the periplasmic space, respectively.

686340:METAL RS12985
gene id: 686340:METAL_RS12985
uniprot id: H8GJM8
names: Subcellular Location Annotation
messages: Membrane

686340:METAL RS07050
gene id: 686340:METAL_RS07050
uniprot id: H8GKR1
names: Similarity
messages: Belongs to the ribosome association toxin RatA family.

686340:METAL RS14345
gene id: 686340:METAL_RS14345
uniprot id: H8GMC3
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

686340:METAL RS02380
gene id: 686340:METAL_RS02380
uniprot id: H8GNA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

686340:METAL RS13695
gene id: 686340:METAL_RS13695
uniprot id: H8GL42
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

686340:METAL RS02610
gene id: 686340:METAL_RS02610
uniprot id: H8GNV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

686340:METAL RS16995
gene id: 686340:METAL_RS16995
uniprot id: H8GRH4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. FtsW subfamily.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell division.

686340:METAL RS07215
gene id: 686340:METAL_RS07215
uniprot id: H8GKU4
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

686340:METAL RS14805
gene id: 686340:METAL_RS14805
uniprot id: H8GN24
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

686340:METAL RS17825
gene id: 686340:METAL_RS17825
uniprot id: H8GH43
names: Similarity
messages: Belongs to the peptidase M24B family.

686340:METAL RS18220
gene id: 686340:METAL_RS18220
uniprot id: H8GHT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

686340:METAL RS04345
gene id: 686340:METAL_RS04345
uniprot id: H8GFV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the VapD ribonuclease family.
messages: Cleaves ssRNA, mostly between U:A.
messages: Homodimer.

686340:METAL RS02305
gene id: 686340:METAL_RS02305
uniprot id: H8GN93
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

686340:METAL RS17730
gene id: 686340:METAL_RS17730
uniprot id: H8GH23
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

686340:METAL RS03260
gene id: 686340:METAL_RS03260
uniprot id: H8GPP5
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

686340:METAL RS04115
gene id: 686340:METAL_RS04115
uniprot id: H8GR07
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS11235
gene id: 686340:METAL_RS11235
uniprot id: H8GGT9
names: Similarity
messages: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.

686340:METAL RS16685
gene id: 686340:METAL_RS16685
uniprot id: H8GRB2
names: Similarity
messages: Belongs to the TrpC family.

686340:METAL RS02185
gene id: 686340:METAL_RS02185
uniprot id: H8GN71
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

686340:METAL RS16840
gene id: 686340:METAL_RS16840
uniprot id: H8GRE4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

686340:METAL RS10060
gene id: 686340:METAL_RS10060
uniprot id: H8GQK2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

686340:METAL RS10715
gene id: 686340:METAL_RS10715
uniprot id: H8GG31
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS06215
gene id: 686340:METAL_RS06215
uniprot id: H8GIP5
names: Similarity
messages: Belongs to the MotB family.

686340:METAL RS14145
gene id: 686340:METAL_RS14145
uniprot id: H8GLT0
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

686340:METAL RS01330
gene id: 686340:METAL_RS01330
uniprot id: H8GLD5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

686340:METAL RS11115
gene id: 686340:METAL_RS11115
uniprot id: H8GGR4
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

686340:METAL RS00470
gene id: 686340:METAL_RS00470
uniprot id: H8GK09
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Converts GTP to 7,8-dihydroneopterin triphosphate.

686340:METAL RS09415
gene id: 686340:METAL_RS09415
uniprot id: H8GPS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamB family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

686340:METAL RS07070
gene id: 686340:METAL_RS07070
uniprot id: H8GKR5
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

686340:METAL RS12945
gene id: 686340:METAL_RS12945
uniprot id: H8GJM1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

686340:METAL RS08845
gene id: 686340:METAL_RS08845
uniprot id: H8GNJ6
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.

686340:METAL RS11300
gene id: 686340:METAL_RS11300
uniprot id: H8GGV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

686340:METAL RS19325
gene id: 686340:METAL_RS19325
uniprot id: H8GJS8
names: Similarity
messages: Belongs to the citrate synthase family.

686340:METAL RS04905
gene id: 686340:METAL_RS04905
uniprot id: H8GGM4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

686340:METAL RS00460
gene id: 686340:METAL_RS00460
uniprot id: H8GK07
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

686340:METAL RS01975
gene id: 686340:METAL_RS01975
uniprot id: H8GML7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

686340:METAL RS15935
gene id: 686340:METAL_RS15935
uniprot id: H8GQ15
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

686340:METAL RS05165
gene id: 686340:METAL_RS05165
uniprot id: H8GH79
names: Similarity
messages: Belongs to the truncated hemoglobin family. Group II subfamily.

686340:METAL RS13590
gene id: 686340:METAL_RS13590
uniprot id: H8GL21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

686340:METAL RS15545
gene id: 686340:METAL_RS15545
uniprot id: H8GPD2
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.