679901:MZHIL RS08080
gene id: 679901:MZHIL_RS08080
uniprot id: F7XPL3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

679901:MZHIL RS00025
gene id: 679901:MZHIL_RS00025
uniprot id: F7XMG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

679901:MZHIL RS00380
gene id: 679901:MZHIL_RS00380
uniprot id: F7XMT6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679901:MZHIL RS09435
gene id: 679901:MZHIL_RS09435
uniprot id: F7XKE4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

679901:MZHIL RS04910
gene id: 679901:MZHIL_RS04910
uniprot id: F7XLK7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679901:MZHIL RS00900
gene id: 679901:MZHIL_RS00900
uniprot id: F7XN94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

679901:MZHIL RS02105
gene id: 679901:MZHIL_RS02105
uniprot id: F7XPF9
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

679901:MZHIL RS01615
gene id: 679901:MZHIL_RS01615
uniprot id: F7XNZ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

679901:MZHIL RS09185
gene id: 679901:MZHIL_RS09185
uniprot id: F7XQR2
names: Similarity
messages: Belongs to the MoaB/Mog family.

679901:MZHIL RS07005
gene id: 679901:MZHIL_RS07005
uniprot id: F7XNH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

679901:MZHIL RS06305
gene id: 679901:MZHIL_RS06305
uniprot id: F7XMY9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679901:MZHIL RS06675
gene id: 679901:MZHIL_RS06675
uniprot id: F7XNC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

679901:MZHIL RS05150
gene id: 679901:MZHIL_RS05150
uniprot id: F7XLP5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

679901:MZHIL RS09120
gene id: 679901:MZHIL_RS09120
uniprot id: F7XQQ0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

679901:MZHIL RS02565
gene id: 679901:MZHIL_RS02565
uniprot id: F7XQ11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

679901:MZHIL RS01035
gene id: 679901:MZHIL_RS01035
uniprot id: F7XNB6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

679901:MZHIL RS07045
gene id: 679901:MZHIL_RS07045
uniprot id: F7XNI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

679901:MZHIL RS06365
gene id: 679901:MZHIL_RS06365
uniprot id: F7XN02
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

679901:MZHIL RS03225
gene id: 679901:MZHIL_RS03225
uniprot id: F7XQJ6
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

679901:MZHIL RS05080
gene id: 679901:MZHIL_RS05080
uniprot id: F7XLQ8
names: Similarity
messages: Belongs to the UPF0285 family.

679901:MZHIL RS02615
gene id: 679901:MZHIL_RS02615
uniprot id: F7XQ21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

679901:MZHIL RS01395
gene id: 679901:MZHIL_RS01395
uniprot id: F7XNN8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS05875
gene id: 679901:MZHIL_RS05875
uniprot id: F7XMB5
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

679901:MZHIL RS02645
gene id: 679901:MZHIL_RS02645
uniprot id: F7XQ25
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

679901:MZHIL RS05325
gene id: 679901:MZHIL_RS05325
uniprot id: F7XLX8
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

679901:MZHIL RS00160
gene id: 679901:MZHIL_RS00160
uniprot id: F7XMJ0
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

679901:MZHIL RS02685
gene id: 679901:MZHIL_RS02685
uniprot id: F7XQ33
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS02585
gene id: 679901:MZHIL_RS02585
uniprot id: F7XQ15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

679901:MZHIL RS03530
gene id: 679901:MZHIL_RS03530
uniprot id: F7XLF9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

679901:MZHIL RS02750
gene id: 679901:MZHIL_RS02750
uniprot id: F7XQ46
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

679901:MZHIL RS03890
gene id: 679901:MZHIL_RS03890
uniprot id: F7XKM5
names: Similarity
messages: Belongs to the HerA family.

679901:MZHIL RS06860
gene id: 679901:MZHIL_RS06860
uniprot id: F7XNF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

679901:MZHIL RS08190
gene id: 679901:MZHIL_RS08190
uniprot id: F7XPU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

679901:MZHIL RS02665
gene id: 679901:MZHIL_RS02665
uniprot id: F7XQ29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

679901:MZHIL RS08025
gene id: 679901:MZHIL_RS08025
uniprot id: F7XPK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: FPO is composed of at least 12 different subunits. Subunits FpoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: FPO shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to quinones in the F(420)H(2):heterodisulfide oxidoreduction chain. The immediate electron acceptor for the enzyme in this species is believed to be methanophenazine. Couples the redox reaction to proton translocation (for every two electrons transferred, 0.9 hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
messages: Membrane

679901:MZHIL RS03875
gene id: 679901:MZHIL_RS03875
uniprot id: F7XKM2
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

679901:MZHIL RS07445
gene id: 679901:MZHIL_RS07445
uniprot id: F7XP29
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

679901:MZHIL RS02550
gene id: 679901:MZHIL_RS02550
uniprot id: F7XPU2
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

679901:MZHIL RS08825
gene id: 679901:MZHIL_RS08825
uniprot id: F7XMC4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

679901:MZHIL RS08685
gene id: 679901:MZHIL_RS08685
uniprot id: F7XQA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

679901:MZHIL RS02045
gene id: 679901:MZHIL_RS02045
uniprot id: F7XPE6
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS08360
gene id: 679901:MZHIL_RS08360
uniprot id: F7XPX7
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS04510
gene id: 679901:MZHIL_RS04510
uniprot id: F7XL92
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

679901:MZHIL RS07625
gene id: 679901:MZHIL_RS07625
uniprot id: F7XP66
names: Similarity
messages: Belongs to the DtxR/MntR family.

679901:MZHIL RS06330
gene id: 679901:MZHIL_RS06330
uniprot id: F7XMZ4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

679901:MZHIL RS09895
gene id: 679901:MZHIL_RS09895
uniprot id: F7XKT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

679901:MZHIL RS05910
gene id: 679901:MZHIL_RS05910
uniprot id: F7XLT4
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

679901:MZHIL RS04445
gene id: 679901:MZHIL_RS04445
uniprot id: F7XL27
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

679901:MZHIL RS02485
gene id: 679901:MZHIL_RS02485
uniprot id: F7XPT5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

679901:MZHIL RS05245
gene id: 679901:MZHIL_RS05245
uniprot id: F7XLW4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679901:MZHIL RS02480
gene id: 679901:MZHIL_RS02480
uniprot id: F7XPT4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

679901:MZHIL RS04210
gene id: 679901:MZHIL_RS04210
uniprot id: F7XKY9
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

679901:MZHIL RS05640
gene id: 679901:MZHIL_RS05640
uniprot id: F7XM81
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

679901:MZHIL RS00615
gene id: 679901:MZHIL_RS00615
uniprot id: F7XMX6
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

679901:MZHIL RS03570
gene id: 679901:MZHIL_RS03570
uniprot id: F7XKA0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

679901:MZHIL RS09390
gene id: 679901:MZHIL_RS09390
uniprot id: F7XKD5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

679901:MZHIL RS07675
gene id: 679901:MZHIL_RS07675
uniprot id: F7XP71
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

679901:MZHIL RS01865
gene id: 679901:MZHIL_RS01865
uniprot id: F7XPB1
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

679901:MZHIL RS03185
gene id: 679901:MZHIL_RS03185
uniprot id: F7XQI9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS02100
gene id: 679901:MZHIL_RS02100
uniprot id: F7XPF8
names: Similarity
messages: Belongs to the eIF-2-alpha family.

679901:MZHIL RS00425
gene id: 679901:MZHIL_RS00425
uniprot id: F7XMU5
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

679901:MZHIL RS04825
gene id: 679901:MZHIL_RS04825
uniprot id: F7XLJ1
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS09610
gene id: 679901:MZHIL_RS09610
uniprot id: F7XKH3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS04000
gene id: 679901:MZHIL_RS04000
uniprot id: F7XLH3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

679901:MZHIL RS02310
gene id: 679901:MZHIL_RS02310
uniprot id: F7XPQ5
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

679901:MZHIL RS09150
gene id: 679901:MZHIL_RS09150
uniprot id: F7XQQ6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

679901:MZHIL RS02275
gene id: 679901:MZHIL_RS02275
uniprot id: F7XPQ1
names: Similarity
messages: Belongs to the CutA family.

679901:MZHIL RS06150
gene id: 679901:MZHIL_RS06150
uniprot id: F7XMP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

679901:MZHIL RS09565
gene id: 679901:MZHIL_RS09565
uniprot id: F7XKG5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS04300
gene id: 679901:MZHIL_RS04300
uniprot id: F7XL05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

679901:MZHIL RS09775
gene id: 679901:MZHIL_RS09775
uniprot id: F7XKR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

679901:MZHIL RS06060
gene id: 679901:MZHIL_RS06060
uniprot id: F7XMN5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

679901:MZHIL RS08355
gene id: 679901:MZHIL_RS08355
uniprot id: F7XPX6
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

679901:MZHIL RS01610
gene id: 679901:MZHIL_RS01610
uniprot id: F7XNZ4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

679901:MZHIL RS06380
gene id: 679901:MZHIL_RS06380
uniprot id: F7XN05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

679901:MZHIL RS09680
gene id: 679901:MZHIL_RS09680
uniprot id: F7XKI8
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

679901:MZHIL RS07735
gene id: 679901:MZHIL_RS07735
uniprot id: F7XP82
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS02240
gene id: 679901:MZHIL_RS02240
uniprot id: F7XPP5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

679901:MZHIL RS09810
gene id: 679901:MZHIL_RS09810
uniprot id: F7XKS5
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

679901:MZHIL RS05580
gene id: 679901:MZHIL_RS05580
uniprot id: F7XM70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

679901:MZHIL RS05495
gene id: 679901:MZHIL_RS05495
uniprot id: F7XLS0
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

679901:MZHIL RS08565
gene id: 679901:MZHIL_RS08565
uniprot id: F7XM63
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

679901:MZHIL RS00460
gene id: 679901:MZHIL_RS00460
uniprot id: F7XMV2
names: Similarity
messages: Belongs to the peptidase M24B family.

679901:MZHIL RS10160
gene id: 679901:MZHIL_RS10160
uniprot id: F7XL43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

679901:MZHIL RS05300
gene id: 679901:MZHIL_RS05300
uniprot id: F7XLX4
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase family.
messages: Binds 1 FAD per subunit.

679901:MZHIL RS04020
gene id: 679901:MZHIL_RS04020
uniprot id: F7XKP4
names: Similarity
messages: Belongs to the UPF0284 family.

679901:MZHIL RS05690
gene id: 679901:MZHIL_RS05690
uniprot id: F7XM91
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

679901:MZHIL RS02475
gene id: 679901:MZHIL_RS02475
uniprot id: F7XPT3
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

679901:MZHIL RS01990
gene id: 679901:MZHIL_RS01990
uniprot id: F7XL77
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

679901:MZHIL RS09205
gene id: 679901:MZHIL_RS09205
uniprot id: F7XQR6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

679901:MZHIL RS03950
gene id: 679901:MZHIL_RS03950
uniprot id: F7XKN2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

679901:MZHIL RS05250
gene id: 679901:MZHIL_RS05250
uniprot id: F7XLW5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679901:MZHIL RS09430
gene id: 679901:MZHIL_RS09430
uniprot id: F7XKE3
names: Similarity
messages: Belongs to the PurH family.

679901:MZHIL RS02690
gene id: 679901:MZHIL_RS02690
uniprot id: F7XQ34
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

679901:MZHIL RS03625
gene id: 679901:MZHIL_RS03625
uniprot id: F7XKA9
names: Similarity
messages: Belongs to the glutaredoxin family.

679901:MZHIL RS05125
gene id: 679901:MZHIL_RS05125
uniprot id: F7XLP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

679901:MZHIL RS07415
gene id: 679901:MZHIL_RS07415
uniprot id: F7XNV8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS09980
gene id: 679901:MZHIL_RS09980
uniprot id: F7XKV2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

679901:MZHIL RS04525
gene id: 679901:MZHIL_RS04525
uniprot id: F7XL95
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

679901:MZHIL RS06315
gene id: 679901:MZHIL_RS06315
uniprot id: F7XMZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

679901:MZHIL RS08345
gene id: 679901:MZHIL_RS08345
uniprot id: F7XPX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Heterotetramer of 2 HacA and 2 HacB proteins.
messages: Hydro-lyase with broad substrate specificity for cis-unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4-tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B.

679901:MZHIL RS07435
gene id: 679901:MZHIL_RS07435
uniprot id: F7XP27
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

679901:MZHIL RS03075
gene id: 679901:MZHIL_RS03075
uniprot id: F7XQH0
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

679901:MZHIL RS01180
gene id: 679901:MZHIL_RS01180
uniprot id: F7XNK7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS08000
gene id: 679901:MZHIL_RS08000
uniprot id: F7XPK4
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS03495
gene id: 679901:MZHIL_RS03495
uniprot id: F7XK88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

679901:MZHIL RS02385
gene id: 679901:MZHIL_RS02385
uniprot id: F7XPR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homodimer.

679901:MZHIL RS07820
gene id: 679901:MZHIL_RS07820
uniprot id: F7XPH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

679901:MZHIL RS08865
gene id: 679901:MZHIL_RS08865
uniprot id: F7XQD3
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

679901:MZHIL RS07740
gene id: 679901:MZHIL_RS07740
uniprot id: F7XP83
names: Similarity
messages: Belongs to the UPF0107 family.

679901:MZHIL RS07115
gene id: 679901:MZHIL_RS07115
uniprot id: F7XNQ6
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS07365
gene id: 679901:MZHIL_RS07365
uniprot id: F7XNU8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679901:MZHIL RS09520
gene id: 679901:MZHIL_RS09520
uniprot id: F7XKF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

679901:MZHIL RS05060
gene id: 679901:MZHIL_RS05060
uniprot id: F7XLN3
names: Similarity
messages: Belongs to the UPF0758 family.

679901:MZHIL RS05945
gene id: 679901:MZHIL_RS05945
uniprot id: F7XML3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

679901:MZHIL RS00495
gene id: 679901:MZHIL_RS00495
uniprot id: F7XMV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

679901:MZHIL RS07120
gene id: 679901:MZHIL_RS07120
uniprot id: F7XNQ8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily.
messages: Binds 1 Zn(2+) ion per subunit. This ion is coordinated with 2 cysteines, 1 glutamate and a water molecule that dissociates from the zinc ion to allow the coordination of the amino group of the serine substrate, which is essential for catalysis.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is presumably involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer.

679901:MZHIL RS06425
gene id: 679901:MZHIL_RS06425
uniprot id: F7XN13
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

679901:MZHIL RS04170
gene id: 679901:MZHIL_RS04170
uniprot id: F7XKY1
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

679901:MZHIL RS09500
gene id: 679901:MZHIL_RS09500
uniprot id: F7XME2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679901:MZHIL RS01175
gene id: 679901:MZHIL_RS01175
uniprot id: F7XNK6
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

679901:MZHIL RS01590
gene id: 679901:MZHIL_RS01590
uniprot id: F7XNZ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

679901:MZHIL RS09715
gene id: 679901:MZHIL_RS09715
uniprot id: F7XKQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

679901:MZHIL RS07595
gene id: 679901:MZHIL_RS07595
uniprot id: F7XP59
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

679901:MZHIL RS09990
gene id: 679901:MZHIL_RS09990
uniprot id: F7XKV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

679901:MZHIL RS09230
gene id: 679901:MZHIL_RS09230
uniprot id: F7XQR9
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS03350
gene id: 679901:MZHIL_RS03350
uniprot id: F7XK58
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

679901:MZHIL RS04360
gene id: 679901:MZHIL_RS04360
uniprot id: F7XLI3
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

679901:MZHIL RS08070
gene id: 679901:MZHIL_RS08070
uniprot id: F7XPL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

679901:MZHIL RS05955
gene id: 679901:MZHIL_RS05955
uniprot id: F7XML5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

679901:MZHIL RS02175
gene id: 679901:MZHIL_RS02175
uniprot id: F7XPN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

679901:MZHIL RS06240
gene id: 679901:MZHIL_RS06240
uniprot id: F7XMR2
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

679901:MZHIL RS08730
gene id: 679901:MZHIL_RS08730
uniprot id: F7XQB0
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

679901:MZHIL RS06125
gene id: 679901:MZHIL_RS06125
uniprot id: F7XMP4
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

679901:MZHIL RS08435
gene id: 679901:MZHIL_RS08435
uniprot id: F7XM59
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

679901:MZHIL RS10025
gene id: 679901:MZHIL_RS10025
uniprot id: F7XMF4
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS06940
gene id: 679901:MZHIL_RS06940
uniprot id: F7XM22
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

679901:MZHIL RS06355
gene id: 679901:MZHIL_RS06355
uniprot id: F7XMZ9
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

679901:MZHIL RS09280
gene id: 679901:MZHIL_RS09280
uniprot id: F7XQS5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

679901:MZHIL RS05950
gene id: 679901:MZHIL_RS05950
uniprot id: F7XML4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

679901:MZHIL RS02235
gene id: 679901:MZHIL_RS02235
uniprot id: F7XPP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

679901:MZHIL RS06100
gene id: 679901:MZHIL_RS06100
uniprot id: F7XMP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

679901:MZHIL RS01460
gene id: 679901:MZHIL_RS01460
uniprot id: F7XNW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

679901:MZHIL RS09320
gene id: 679901:MZHIL_RS09320
uniprot id: F7XKC1
names: Similarity
messages: Belongs to the SAICAR synthetase family.

679901:MZHIL RS00735
gene id: 679901:MZHIL_RS00735
uniprot id: F7XN62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

679901:MZHIL RS08410
gene id: 679901:MZHIL_RS08410
uniprot id: F7XPY5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

679901:MZHIL RS06075
gene id: 679901:MZHIL_RS06075
uniprot id: F7XMN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

679901:MZHIL RS03510
gene id: 679901:MZHIL_RS03510
uniprot id: F7XK90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

679901:MZHIL RS07545
gene id: 679901:MZHIL_RS07545
uniprot id: F7XP49
names: Similarity
messages: Belongs to the AAA ATPase family.

679901:MZHIL RS09785
gene id: 679901:MZHIL_RS09785
uniprot id: F7XKS0
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the WrbA family.
messages: Binds 1 FMN per monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS01970
gene id: 679901:MZHIL_RS01970
uniprot id: F7XPD2
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

679901:MZHIL RS07075
gene id: 679901:MZHIL_RS07075
uniprot id: F7XNP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

679901:MZHIL RS04985
gene id: 679901:MZHIL_RS04985
uniprot id: F7XLM1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679901:MZHIL RS01385
gene id: 679901:MZHIL_RS01385
uniprot id: F7XNN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

679901:MZHIL RS05390
gene id: 679901:MZHIL_RS05390
uniprot id: F7XLZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

679901:MZHIL RS01015
gene id: 679901:MZHIL_RS01015
uniprot id: F7XNB3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

679901:MZHIL RS08445
gene id: 679901:MZHIL_RS08445
uniprot id: F7XM60
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679901:MZHIL RS00285
gene id: 679901:MZHIL_RS00285
uniprot id: F7XMK5
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

679901:MZHIL RS09545
gene id: 679901:MZHIL_RS09545
uniprot id: F7XKG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

679901:MZHIL RS02285
gene id: 679901:MZHIL_RS02285
uniprot id: F7XPQ2
names: Similarity
messages: Belongs to the class-I fumarase family.

679901:MZHIL RS10185
gene id: 679901:MZHIL_RS10185
uniprot id: F7XN75
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS03335
gene id: 679901:MZHIL_RS03335
uniprot id: F7XK55
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

679901:MZHIL RS03585
gene id: 679901:MZHIL_RS03585
uniprot id: F7XLG2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS01845
gene id: 679901:MZHIL_RS01845
uniprot id: F7XPA7
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

679901:MZHIL RS08100
gene id: 679901:MZHIL_RS08100
uniprot id: F7XPL7
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS08605
gene id: 679901:MZHIL_RS08605
uniprot id: F7XQ85
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679901:MZHIL RS07305
gene id: 679901:MZHIL_RS07305
uniprot id: F7XNT9
names: Similarity
messages: Belongs to the pirin family.

679901:MZHIL RS02760
gene id: 679901:MZHIL_RS02760
uniprot id: F7XQ48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

679901:MZHIL RS02145
gene id: 679901:MZHIL_RS02145
uniprot id: F7XPG7
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

679901:MZHIL RS08635
gene id: 679901:MZHIL_RS08635
uniprot id: F7XQ91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

679901:MZHIL RS03020
gene id: 679901:MZHIL_RS03020
uniprot id: F7XQF9
names: Similarity
messages: Belongs to the MCM family.

679901:MZHIL RS09330
gene id: 679901:MZHIL_RS09330
uniprot id: F7XKC3
names: Domain
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.
messages: Involved in DNA damage repair.

679901:MZHIL RS03475
gene id: 679901:MZHIL_RS03475
uniprot id: F7XK84
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.

679901:MZHIL RS02675
gene id: 679901:MZHIL_RS02675
uniprot id: F7XQ31
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.

679901:MZHIL RS08715
gene id: 679901:MZHIL_RS08715
uniprot id: F7XQA7
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

679901:MZHIL RS09350
gene id: 679901:MZHIL_RS09350
uniprot id: F7XKC7
names: Similarity
messages: Belongs to the SUI1 family.

679901:MZHIL RS05165
gene id: 679901:MZHIL_RS05165
uniprot id: F7XLP8
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

679901:MZHIL RS04115
gene id: 679901:MZHIL_RS04115
uniprot id: F7XKX2
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

679901:MZHIL RS06895
gene id: 679901:MZHIL_RS06895
uniprot id: F7XNG0
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

679901:MZHIL RS03340
gene id: 679901:MZHIL_RS03340
uniprot id: F7XK56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

679901:MZHIL RS07650
gene id: 679901:MZHIL_RS07650
uniprot id: F7XP71
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

679901:MZHIL RS01620
gene id: 679901:MZHIL_RS01620
uniprot id: F7XNZ6
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

679901:MZHIL RS05600
gene id: 679901:MZHIL_RS05600
uniprot id: F7XM73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

679901:MZHIL RS06115
gene id: 679901:MZHIL_RS06115
uniprot id: F7XMP3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

679901:MZHIL RS06220
gene id: 679901:MZHIL_RS06220
uniprot id: F7XMQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

679901:MZHIL RS02190
gene id: 679901:MZHIL_RS02190
uniprot id: F7XPN5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

679901:MZHIL RS10150
gene id: 679901:MZHIL_RS10150
uniprot id: F7XL41
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

679901:MZHIL RS02460
gene id: 679901:MZHIL_RS02460
uniprot id: F7XPT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

679901:MZHIL RS06605
gene id: 679901:MZHIL_RS06605
uniprot id: F7XN43
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

679901:MZHIL RS02720
gene id: 679901:MZHIL_RS02720
uniprot id: F7XQ40
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

679901:MZHIL RS09295
gene id: 679901:MZHIL_RS09295
uniprot id: F7XQS7
names: Similarity
messages: Belongs to the P(II) protein family.

679901:MZHIL RS06140
gene id: 679901:MZHIL_RS06140
uniprot id: F7XLT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

679901:MZHIL RS00125
gene id: 679901:MZHIL_RS00125
uniprot id: F7XMI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

679901:MZHIL RS05230
gene id: 679901:MZHIL_RS05230
uniprot id: F7XLW1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679901:MZHIL RS09690
gene id: 679901:MZHIL_RS09690
uniprot id: F7XKI9
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

679901:MZHIL RS09755
gene id: 679901:MZHIL_RS09755
uniprot id: F7XKR4
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

679901:MZHIL RS01895
gene id: 679901:MZHIL_RS01895
uniprot id: F7XPB6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679901:MZHIL RS03025
gene id: 679901:MZHIL_RS03025
uniprot id: F7XQG0
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

679901:MZHIL RS07995
gene id: 679901:MZHIL_RS07995
uniprot id: F7XPK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

679901:MZHIL RS05805
gene id: 679901:MZHIL_RS05805
uniprot id: F7XMA6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS06660
gene id: 679901:MZHIL_RS06660
uniprot id: F7XN52
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

679901:MZHIL RS03445
gene id: 679901:MZHIL_RS03445
uniprot id: F7XK78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

679901:MZHIL RS06350
gene id: 679901:MZHIL_RS06350
uniprot id: F7XMZ8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

679901:MZHIL RS01330
gene id: 679901:MZHIL_RS01330
uniprot id: F7XNM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

679901:MZHIL RS03655
gene id: 679901:MZHIL_RS03655
uniprot id: F7XLG4
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

679901:MZHIL RS05755
gene id: 679901:MZHIL_RS05755
uniprot id: F7XM99
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. Probably maintains the overall quaternary structure of the ACDS complex.

679901:MZHIL RS06395
gene id: 679901:MZHIL_RS06395
uniprot id: F7XN07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

679901:MZHIL RS01600
gene id: 679901:MZHIL_RS01600
uniprot id: F7XNZ2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

679901:MZHIL RS06205
gene id: 679901:MZHIL_RS06205
uniprot id: F7XLU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

679901:MZHIL RS02605
gene id: 679901:MZHIL_RS02605
uniprot id: F7XQ19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

679901:MZHIL RS05105
gene id: 679901:MZHIL_RS05105
uniprot id: F7XLN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

679901:MZHIL RS08875
gene id: 679901:MZHIL_RS08875
uniprot id: F7XQD5
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

679901:MZHIL RS05645
gene id: 679901:MZHIL_RS05645
uniprot id: F7XM82
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

679901:MZHIL RS08450
gene id: 679901:MZHIL_RS08450
uniprot id: F7XPZ1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

679901:MZHIL RS07470
gene id: 679901:MZHIL_RS07470
uniprot id: F7XP34
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

679901:MZHIL RS10000
gene id: 679901:MZHIL_RS10000
uniprot id: F7XKV6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

679901:MZHIL RS06110
gene id: 679901:MZHIL_RS06110
uniprot id: F7XLT6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

679901:MZHIL RS07100
gene id: 679901:MZHIL_RS07100
uniprot id: F7XNQ3
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

679901:MZHIL RS05670
gene id: 679901:MZHIL_RS05670
uniprot id: F7XM87
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

679901:MZHIL RS03100
gene id: 679901:MZHIL_RS03100
uniprot id: F7XQH4
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS10135
gene id: 679901:MZHIL_RS10135
uniprot id: F7XL38
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

679901:MZHIL RS09360
gene id: 679901:MZHIL_RS09360
uniprot id: F7XKC9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

679901:MZHIL RS00310
gene id: 679901:MZHIL_RS00310
uniprot id: F7XMS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

679901:MZHIL RS00270
gene id: 679901:MZHIL_RS00270
uniprot id: F7XL50
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS04500
gene id: 679901:MZHIL_RS04500
uniprot id: F7XL90
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS01200
gene id: 679901:MZHIL_RS01200
uniprot id: F7XNL1
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

679901:MZHIL RS02660
gene id: 679901:MZHIL_RS02660
uniprot id: F7XQ28
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679901:MZHIL RS09745
gene id: 679901:MZHIL_RS09745
uniprot id: F7XKR2
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

679901:MZHIL RS03210
gene id: 679901:MZHIL_RS03210
uniprot id: F7XQJ4
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

679901:MZHIL RS00765
gene id: 679901:MZHIL_RS00765
uniprot id: F7XN68
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

679901:MZHIL RS08925
gene id: 679901:MZHIL_RS08925
uniprot id: F7XMC9
names: Cofactor
messages: Binds 2 irons ions per subunit via 4 cysteine residues per iron.

679901:MZHIL RS01410
gene id: 679901:MZHIL_RS01410
uniprot id: F7XNP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

679901:MZHIL RS05095
gene id: 679901:MZHIL_RS05095
uniprot id: F7XLN8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

679901:MZHIL RS01765
gene id: 679901:MZHIL_RS01765
uniprot id: F7XP23
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

679901:MZHIL RS01305
gene id: 679901:MZHIL_RS01305
uniprot id: F7XL66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

679901:MZHIL RS01800
gene id: 679901:MZHIL_RS01800
uniprot id: F7XP98
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

679901:MZHIL RS06445
gene id: 679901:MZHIL_RS06445
uniprot id: F7XN17
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

679901:MZHIL RS03880
gene id: 679901:MZHIL_RS03880
uniprot id: F7XKM3
names: Similarity
messages: Belongs to the UPF0212 family.

679901:MZHIL RS04290
gene id: 679901:MZHIL_RS04290
uniprot id: F7XLH8
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

679901:MZHIL RS10040
gene id: 679901:MZHIL_RS10040
uniprot id: F7XKW1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

679901:MZHIL RS08230
gene id: 679901:MZHIL_RS08230
uniprot id: F7XPV3
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS08430
gene id: 679901:MZHIL_RS08430
uniprot id: F7XPY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

679901:MZHIL RS02620
gene id: 679901:MZHIL_RS02620
uniprot id: F7XQ22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

679901:MZHIL RS01945
gene id: 679901:MZHIL_RS01945
uniprot id: F7XPC7
names: Similarity
messages: Belongs to the thymidylate kinase family.

679901:MZHIL RS01705
gene id: 679901:MZHIL_RS01705
uniprot id: F7XP10
names: Similarity
messages: Belongs to the HdrB family.

679901:MZHIL RS02130
gene id: 679901:MZHIL_RS02130
uniprot id: F7XPG4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

679901:MZHIL RS08725
gene id: 679901:MZHIL_RS08725
uniprot id: F7XQA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

679901:MZHIL RS08660
gene id: 679901:MZHIL_RS08660
uniprot id: F7XQ96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

679901:MZHIL RS09735
gene id: 679901:MZHIL_RS09735
uniprot id: F7XKR0
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS08580
gene id: 679901:MZHIL_RS08580
uniprot id: F7XQ80
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

679901:MZHIL RS02520
gene id: 679901:MZHIL_RS02520
uniprot id: F7XPT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

679901:MZHIL RS01375
gene id: 679901:MZHIL_RS01375
uniprot id: F7XNN4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

679901:MZHIL RS03930
gene id: 679901:MZHIL_RS03930
uniprot id: F7XKN0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

679901:MZHIL RS02835
gene id: 679901:MZHIL_RS02835
uniprot id: F7XQ62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

679901:MZHIL RS06175
gene id: 679901:MZHIL_RS06175
uniprot id: F7XMQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

679901:MZHIL RS00400
gene id: 679901:MZHIL_RS00400
uniprot id: F7XMU0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS06360
gene id: 679901:MZHIL_RS06360
uniprot id: F7XN00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

679901:MZHIL RS05630
gene id: 679901:MZHIL_RS05630
uniprot id: F7XM79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

679901:MZHIL RS09600
gene id: 679901:MZHIL_RS09600
uniprot id: F7XKH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

679901:MZHIL RS06135
gene id: 679901:MZHIL_RS06135
uniprot id: F7XMP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

679901:MZHIL RS07515
gene id: 679901:MZHIL_RS07515
uniprot id: F7XP44
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

679901:MZHIL RS09800
gene id: 679901:MZHIL_RS09800
uniprot id: F7XKS3
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

679901:MZHIL RS04515
gene id: 679901:MZHIL_RS04515
uniprot id: F7XL93
names: Similarity
messages: Belongs to the DMRL synthase family.

679901:MZHIL RS06570
gene id: 679901:MZHIL_RS06570
uniprot id: F7XN39
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

679901:MZHIL RS03515
gene id: 679901:MZHIL_RS03515
uniprot id: F7XK91
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

679901:MZHIL RS03705
gene id: 679901:MZHIL_RS03705
uniprot id: F7XKJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

679901:MZHIL RS06170
gene id: 679901:MZHIL_RS06170
uniprot id: F7XMQ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

679901:MZHIL RS01635
gene id: 679901:MZHIL_RS01635
uniprot id: F7XP00
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

679901:MZHIL RS01695
gene id: 679901:MZHIL_RS01695
uniprot id: F7XP08
names: Similarity
messages: Belongs to the monomethylamine methyltransferase family.

679901:MZHIL RS10120
gene id: 679901:MZHIL_RS10120
uniprot id: F7XL35
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

679901:MZHIL RS09440
gene id: 679901:MZHIL_RS09440
uniprot id: F7XKE5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

679901:MZHIL RS07590
gene id: 679901:MZHIL_RS07590
uniprot id: F7XP58
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

679901:MZHIL RS02260
gene id: 679901:MZHIL_RS02260
uniprot id: F7XPP9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

679901:MZHIL RS01465
gene id: 679901:MZHIL_RS01465
uniprot id: F7XNW5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679901:MZHIL RS03895
gene id: 679901:MZHIL_RS03895
uniprot id: F7XKM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

679901:MZHIL RS00120
gene id: 679901:MZHIL_RS00120
uniprot id: F7XMI2
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

679901:MZHIL RS02125
gene id: 679901:MZHIL_RS02125
uniprot id: F7XPG3
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

679901:MZHIL RS02040
gene id: 679901:MZHIL_RS02040
uniprot id: F7XPE5
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS03645
gene id: 679901:MZHIL_RS03645
uniprot id: F7XLG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

679901:MZHIL RS06450
gene id: 679901:MZHIL_RS06450
uniprot id: F7XN18
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

679901:MZHIL RS06455
gene id: 679901:MZHIL_RS06455
uniprot id: F7XN19
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

679901:MZHIL RS04990
gene id: 679901:MZHIL_RS04990
uniprot id: F7XLQ5
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS02655
gene id: 679901:MZHIL_RS02655
uniprot id: F7XQ27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

679901:MZHIL RS03395
gene id: 679901:MZHIL_RS03395
uniprot id: F7XK68
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS09410
gene id: 679901:MZHIL_RS09410
uniprot id: F7XKD9
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

679901:MZHIL RS06945
gene id: 679901:MZHIL_RS06945
uniprot id: F7XNG8
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

679901:MZHIL RS06775
gene id: 679901:MZHIL_RS06775
uniprot id: F7XND8
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

679901:MZHIL RS10090
gene id: 679901:MZHIL_RS10090
uniprot id: F7XL29
names: Similarity
messages: Belongs to the UPF0201 family.

679901:MZHIL RS04140
gene id: 679901:MZHIL_RS04140
uniprot id: F7XKX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

679901:MZHIL RS07485
gene id: 679901:MZHIL_RS07485
uniprot id: F7XP38
names: Similarity
messages: Belongs to the Ahb/Nir family.

679901:MZHIL RS01485
gene id: 679901:MZHIL_RS01485
uniprot id: F7XNW9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

679901:MZHIL RS03665
gene id: 679901:MZHIL_RS03665
uniprot id: F7XKB5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

679901:MZHIL RS06955
gene id: 679901:MZHIL_RS06955
uniprot id: F7XM23
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

679901:MZHIL RS05710
gene id: 679901:MZHIL_RS05710
uniprot id: F7XM95
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

679901:MZHIL RS06280
gene id: 679901:MZHIL_RS06280
uniprot id: F7XMR8
names: Similarity
messages: Belongs to the DtxR/MntR family.

679901:MZHIL RS03825
gene id: 679901:MZHIL_RS03825
uniprot id: F7XKL4
names: Similarity
messages: Belongs to the MtrH family.

679901:MZHIL RS09315
gene id: 679901:MZHIL_RS09315
uniprot id: F7XKC0
names: Similarity
messages: Belongs to the HypE family.

679901:MZHIL RS08500
gene id: 679901:MZHIL_RS08500
uniprot id: F7XQ00
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

679901:MZHIL RS05460
gene id: 679901:MZHIL_RS05460
uniprot id: F7XLR7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

679901:MZHIL RS00750
gene id: 679901:MZHIL_RS00750
uniprot id: F7XN65
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

679901:MZHIL RS08805
gene id: 679901:MZHIL_RS08805
uniprot id: F7XQC3
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

679901:MZHIL RS00500
gene id: 679901:MZHIL_RS00500
uniprot id: F7XMV8
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

679901:MZHIL RS05520
gene id: 679901:MZHIL_RS05520
uniprot id: F7XM11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

679901:MZHIL RS05940
gene id: 679901:MZHIL_RS05940
uniprot id: F7XML2
names: Similarity
messages: Belongs to the SDO1/SBDS family.

679901:MZHIL RS06405
gene id: 679901:MZHIL_RS06405
uniprot id: F7XN09
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

679901:MZHIL RS05615
gene id: 679901:MZHIL_RS05615
uniprot id: F7XM76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

679901:MZHIL RS00005
gene id: 679901:MZHIL_RS00005
uniprot id: F7XMF9
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

679901:MZHIL RS04380
gene id: 679901:MZHIL_RS04380
uniprot id: F7XL16
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

679901:MZHIL RS02185
gene id: 679901:MZHIL_RS02185
uniprot id: F7XPN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

679901:MZHIL RS02445
gene id: 679901:MZHIL_RS02445
uniprot id: F7XPS7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

679901:MZHIL RS08990
gene id: 679901:MZHIL_RS08990
uniprot id: F7XQM5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

679901:MZHIL RS05835
gene id: 679901:MZHIL_RS05835
uniprot id: F7XMB0
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

679901:MZHIL RS09970
gene id: 679901:MZHIL_RS09970
uniprot id: F7XKV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

679901:MZHIL RS02595
gene id: 679901:MZHIL_RS02595
uniprot id: F7XQ17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

679901:MZHIL RS04370
gene id: 679901:MZHIL_RS04370
uniprot id: F7XL14
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

679901:MZHIL RS05225
gene id: 679901:MZHIL_RS05225
uniprot id: F7XLW0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679901:MZHIL RS00390
gene id: 679901:MZHIL_RS00390
uniprot id: F7XMT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

679901:MZHIL RS02330
gene id: 679901:MZHIL_RS02330
uniprot id: F7XPQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

679901:MZHIL RS02120
gene id: 679901:MZHIL_RS02120
uniprot id: F7XPG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

679901:MZHIL RS04415
gene id: 679901:MZHIL_RS04415
uniprot id: F7XL21
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

679901:MZHIL RS06180
gene id: 679901:MZHIL_RS06180
uniprot id: F7XMQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

679901:MZHIL RS10015
gene id: 679901:MZHIL_RS10015
uniprot id: F7XMF3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS10635
gene id: 679901:MZHIL_RS10635
uniprot id: F7XNS6
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

679901:MZHIL RS01790
gene id: 679901:MZHIL_RS01790
uniprot id: F7XP96
names: Similarity
messages: Belongs to the TPP enzyme family.

679901:MZHIL RS07960
gene id: 679901:MZHIL_RS07960
uniprot id: F7XPJ7
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS08600
gene id: 679901:MZHIL_RS08600
uniprot id: F7XQ84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

679901:MZHIL RS08650
gene id: 679901:MZHIL_RS08650
uniprot id: F7XQ94
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

679901:MZHIL RS00975
gene id: 679901:MZHIL_RS00975
uniprot id: F7XNA8
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

679901:MZHIL RS03370
gene id: 679901:MZHIL_RS03370
uniprot id: F7XK62
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS06095
gene id: 679901:MZHIL_RS06095
uniprot id: F7XLT5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

679901:MZHIL RS06745
gene id: 679901:MZHIL_RS06745
uniprot id: F7XND2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

679901:MZHIL RS03360
gene id: 679901:MZHIL_RS03360
uniprot id: F7XK60
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

679901:MZHIL RS00925
gene id: 679901:MZHIL_RS00925
uniprot id: F7XN99
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS06275
gene id: 679901:MZHIL_RS06275
uniprot id: F7XMR7
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

679901:MZHIL RS07765
gene id: 679901:MZHIL_RS07765
uniprot id: F7XP87
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

679901:MZHIL RS06210
gene id: 679901:MZHIL_RS06210
uniprot id: F7XMQ8
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

679901:MZHIL RS00935
gene id: 679901:MZHIL_RS00935
uniprot id: F7XNA1
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.

679901:MZHIL RS04950
gene id: 679901:MZHIL_RS04950
uniprot id: F7XLL5
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

679901:MZHIL RS02650
gene id: 679901:MZHIL_RS02650
uniprot id: F7XQ26
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679901:MZHIL RS08630
gene id: 679901:MZHIL_RS08630
uniprot id: F7XQ90
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

679901:MZHIL RS07900
gene id: 679901:MZHIL_RS07900
uniprot id: F7XPI5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

679901:MZHIL RS09260
gene id: 679901:MZHIL_RS09260
uniprot id: F7XMD6
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

679901:MZHIL RS08315
gene id: 679901:MZHIL_RS08315
uniprot id: F7XPW8
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

679901:MZHIL RS08220
gene id: 679901:MZHIL_RS08220
uniprot id: F7XPV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

679901:MZHIL RS10095
gene id: 679901:MZHIL_RS10095
uniprot id: F7XL30
names: Similarity
messages: Belongs to the UPF0200 family.

679901:MZHIL RS02960
gene id: 679901:MZHIL_RS02960
uniprot id: F7XQE7
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

679901:MZHIL RS08405
gene id: 679901:MZHIL_RS08405
uniprot id: F7XM57
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

679901:MZHIL RS00930
gene id: 679901:MZHIL_RS00930
uniprot id: F7XNA0
names: Caution
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS08115
gene id: 679901:MZHIL_RS08115
uniprot id: F7XPL9
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

679901:MZHIL RS02400
gene id: 679901:MZHIL_RS02400
uniprot id: F7XLE7
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

679901:MZHIL RS03440
gene id: 679901:MZHIL_RS03440
uniprot id: F7XK77
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

679901:MZHIL RS09630
gene id: 679901:MZHIL_RS09630
uniprot id: F7XKH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

679901:MZHIL RS00015
gene id: 679901:MZHIL_RS00015
uniprot id: F7XMG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

679901:MZHIL RS06185
gene id: 679901:MZHIL_RS06185
uniprot id: F7XMQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

679901:MZHIL RS07500
gene id: 679901:MZHIL_RS07500
uniprot id: F7XP41
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

679901:MZHIL RS06200
gene id: 679901:MZHIL_RS06200
uniprot id: F7XMQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

679901:MZHIL RS05625
gene id: 679901:MZHIL_RS05625
uniprot id: F7XM78
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

679901:MZHIL RS04800
gene id: 679901:MZHIL_RS04800
uniprot id: F7XLQ1
names: Subcellular Location Annotation
messages: Cell membrane

679901:MZHIL RS06885
gene id: 679901:MZHIL_RS06885
uniprot id: F7XNF8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

679901:MZHIL RS03900
gene id: 679901:MZHIL_RS03900
uniprot id: F7XLG7
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

679901:MZHIL RS02050
gene id: 679901:MZHIL_RS02050
uniprot id: F7XPE7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

679901:MZHIL RS04650
gene id: 679901:MZHIL_RS04650
uniprot id: F7XLC0
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

679901:MZHIL RS06915
gene id: 679901:MZHIL_RS06915
uniprot id: F7XNG4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS04200
gene id: 679901:MZHIL_RS04200
uniprot id: F7XKY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

679901:MZHIL RS07850
gene id: 679901:MZHIL_RS07850
uniprot id: F7XPH6
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

679901:MZHIL RS02360
gene id: 679901:MZHIL_RS02360
uniprot id: F7XPR5
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

679901:MZHIL RS01780
gene id: 679901:MZHIL_RS01780
uniprot id: F7XP26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

679901:MZHIL RS01440
gene id: 679901:MZHIL_RS01440
uniprot id: F7XNW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.

679901:MZHIL RS00820
gene id: 679901:MZHIL_RS00820
uniprot id: F7XN80
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

679901:MZHIL RS05045
gene id: 679901:MZHIL_RS05045
uniprot id: F7XLN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

679901:MZHIL RS08645
gene id: 679901:MZHIL_RS08645
uniprot id: F7XQ93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

679901:MZHIL RS00825
gene id: 679901:MZHIL_RS00825
uniprot id: F7XN81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

679901:MZHIL RS01265
gene id: 679901:MZHIL_RS01265
uniprot id: F7XNL9
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

679901:MZHIL RS06190
gene id: 679901:MZHIL_RS06190
uniprot id: F7XMQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

679901:MZHIL RS08425
gene id: 679901:MZHIL_RS08425
uniprot id: F7XM58
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

679901:MZHIL RS00905
gene id: 679901:MZHIL_RS00905
uniprot id: F7XN95
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

679901:MZHIL RS01735
gene id: 679901:MZHIL_RS01735
uniprot id: F7XP17
names: Similarity
messages: Belongs to the glutamate synthase family.

679901:MZHIL RS08065
gene id: 679901:MZHIL_RS08065
uniprot id: F7XM51
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

679901:MZHIL RS05475
gene id: 679901:MZHIL_RS05475
uniprot id: F7XM05
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

679901:MZHIL RS07810
gene id: 679901:MZHIL_RS07810
uniprot id: F7XP94
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

679901:MZHIL RS06070
gene id: 679901:MZHIL_RS06070
uniprot id: F7XMN7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

679901:MZHIL RS01955
gene id: 679901:MZHIL_RS01955
uniprot id: F7XPC9
names: Similarity
messages: Belongs to the HisA/HisF family.

679901:MZHIL RS04865
gene id: 679901:MZHIL_RS04865
uniprot id: F7XLJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

679901:MZHIL RS03835
gene id: 679901:MZHIL_RS03835
uniprot id: F7XKL6
names: Similarity
messages: Belongs to the MtxX family.

679901:MZHIL RS01785
gene id: 679901:MZHIL_RS01785
uniprot id: F7XP95
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

679901:MZHIL RS09535
gene id: 679901:MZHIL_RS09535
uniprot id: F7XKG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

679901:MZHIL RS06340
gene id: 679901:MZHIL_RS06340
uniprot id: F7XMZ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

679901:MZHIL RS03595
gene id: 679901:MZHIL_RS03595
uniprot id: F7XKA3
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

679901:MZHIL RS08585
gene id: 679901:MZHIL_RS08585
uniprot id: F7XQ81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

679901:MZHIL RS07455
gene id: 679901:MZHIL_RS07455
uniprot id: F7XP31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

679901:MZHIL RS06080
gene id: 679901:MZHIL_RS06080
uniprot id: F7XMN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane

679901:MZHIL RS06630
gene id: 679901:MZHIL_RS06630
uniprot id: F7XN46
names: Similarity
messages: Belongs to the AHA1 family.

679901:MZHIL RS10190
gene id: 679901:MZHIL_RS10190
uniprot id: F7XK72
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS08045
gene id: 679901:MZHIL_RS08045
uniprot id: F7XPK8
names: Similarity
messages: Belongs to the complex I subunit 3 family.

679901:MZHIL RS02765
gene id: 679901:MZHIL_RS02765
uniprot id: F7XQ49
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

679901:MZHIL RS09155
gene id: 679901:MZHIL_RS09155
uniprot id: F7XQQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

679901:MZHIL RS03620
gene id: 679901:MZHIL_RS03620
uniprot id: F7XKA8
names: Subcellular Location Annotation
messages: Cytoplasm

679901:MZHIL RS03985
gene id: 679901:MZHIL_RS03985
uniprot id: F7XKN8
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

679901:MZHIL RS04705
gene id: 679901:MZHIL_RS04705
uniprot id: F7XLC9
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

679901:MZHIL RS01650
gene id: 679901:MZHIL_RS01650
uniprot id: F7XP02
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

679901:MZHIL RS07490
gene id: 679901:MZHIL_RS07490
uniprot id: F7XP39
names: Similarity
messages: Belongs to the Ahb/Nir family.

679901:MZHIL RS08815
gene id: 679901:MZHIL_RS08815
uniprot id: F7XMC3
names: Similarity
messages: Belongs to the tRNA(His) guanylyltransferase family.

679901:MZHIL RS04530
gene id: 679901:MZHIL_RS04530
uniprot id: F7XL96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

679901:MZHIL RS07420
gene id: 679901:MZHIL_RS07420
uniprot id: F7XM35
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

679901:MZHIL RS02715
gene id: 679901:MZHIL_RS02715
uniprot id: F7XQ39
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

679901:MZHIL RS07690
gene id: 679901:MZHIL_RS07690
uniprot id: F7XP74
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS08705
gene id: 679901:MZHIL_RS08705
uniprot id: F7XQA5
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

679901:MZHIL RS06300
gene id: 679901:MZHIL_RS06300
uniprot id: F7XMY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

679901:MZHIL RS09570
gene id: 679901:MZHIL_RS09570
uniprot id: F7XKG6
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

679901:MZHIL RS08120
gene id: 679901:MZHIL_RS08120
uniprot id: F7XM53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

679901:MZHIL RS02920
gene id: 679901:MZHIL_RS02920
uniprot id: F7XQ75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

679901:MZHIL RS02775
gene id: 679901:MZHIL_RS02775
uniprot id: F7XQ51
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS08420
gene id: 679901:MZHIL_RS08420
uniprot id: F7XPY8
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

679901:MZHIL RS04675
gene id: 679901:MZHIL_RS04675
uniprot id: F7XLC4
names: Similarity
messages: Belongs to the HypE family.

679901:MZHIL RS08700
gene id: 679901:MZHIL_RS08700
uniprot id: F7XQA4
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

679901:MZHIL RS09700
gene id: 679901:MZHIL_RS09700
uniprot id: F7XKQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

679901:MZHIL RS02180
gene id: 679901:MZHIL_RS02180
uniprot id: F7XPN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

679901:MZHIL RS02110
gene id: 679901:MZHIL_RS02110
uniprot id: F7XPG0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

679901:MZHIL RS02055
gene id: 679901:MZHIL_RS02055
uniprot id: F7XPE8
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS02375
gene id: 679901:MZHIL_RS02375
uniprot id: F7XPR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

679901:MZHIL RS05700
gene id: 679901:MZHIL_RS05700
uniprot id: F7XM93
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

679901:MZHIL RS08955
gene id: 679901:MZHIL_RS08955
uniprot id: F7XQL8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679901:MZHIL RS07510
gene id: 679901:MZHIL_RS07510
uniprot id: F7XP43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

679901:MZHIL RS06410
gene id: 679901:MZHIL_RS06410
uniprot id: F7XN10
names: Caution
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transcriptional regulator.

679901:MZHIL RS09085
gene id: 679901:MZHIL_RS09085
uniprot id: F7XQP4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS06795
gene id: 679901:MZHIL_RS06795
uniprot id: F7XNE2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

679901:MZHIL RS09175
gene id: 679901:MZHIL_RS09175
uniprot id: F7XQR1
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

679901:MZHIL RS08520
gene id: 679901:MZHIL_RS08520
uniprot id: F7XQ03
names: Similarity
messages: Belongs to the catalase family.

679901:MZHIL RS03040
gene id: 679901:MZHIL_RS03040
uniprot id: F7XQG3
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS02540
gene id: 679901:MZHIL_RS02540
uniprot id: F7XPU0
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

679901:MZHIL RS04185
gene id: 679901:MZHIL_RS04185
uniprot id: F7XKY4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

679901:MZHIL RS10140
gene id: 679901:MZHIL_RS10140
uniprot id: F7XL39
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

679901:MZHIL RS08095
gene id: 679901:MZHIL_RS08095
uniprot id: F7XPL6
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS09170
gene id: 679901:MZHIL_RS09170
uniprot id: F7XQR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

679901:MZHIL RS05480
gene id: 679901:MZHIL_RS05480
uniprot id: F7XLR9
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

679901:MZHIL RS08320
gene id: 679901:MZHIL_RS08320
uniprot id: F7XPW9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

679901:MZHIL RS04655
gene id: 679901:MZHIL_RS04655
uniprot id: F7XLC1
names: Similarity
messages: Belongs to the HupF/HypC family.

679901:MZHIL RS01420
gene id: 679901:MZHIL_RS01420
uniprot id: F7XL71
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

679901:MZHIL RS05920
gene id: 679901:MZHIL_RS05920
uniprot id: F7XMK8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

679901:MZHIL RS01380
gene id: 679901:MZHIL_RS01380
uniprot id: F7XNN5
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

679901:MZHIL RS09725
gene id: 679901:MZHIL_RS09725
uniprot id: F7XKQ8
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS07225
gene id: 679901:MZHIL_RS07225
uniprot id: F7XNS8
names: Similarity
messages: Belongs to the HsdR family.

679901:MZHIL RS01810
gene id: 679901:MZHIL_RS01810
uniprot id: F7XPA0
names: Function
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

679901:MZHIL RS05215
gene id: 679901:MZHIL_RS05215
uniprot id: F7XLV8
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

679901:MZHIL RS01720
gene id: 679901:MZHIL_RS01720
uniprot id: F7XP14
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

679901:MZHIL RS09275
gene id: 679901:MZHIL_RS09275
uniprot id: F7XMD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

679901:MZHIL RS06155
gene id: 679901:MZHIL_RS06155
uniprot id: F7XMP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

679901:MZHIL RS09020
gene id: 679901:MZHIL_RS09020
uniprot id: F7XQN1
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

679901:MZHIL RS09985
gene id: 679901:MZHIL_RS09985
uniprot id: F7XKV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

679901:MZHIL RS08785
gene id: 679901:MZHIL_RS08785
uniprot id: F7XQC0
names: Similarity
messages: Belongs to the archaeal-type GPI family.

679901:MZHIL RS08760
gene id: 679901:MZHIL_RS08760
uniprot id: F7XQB6
names: Similarity
messages: Belongs to the UPF0047 family.

679901:MZHIL RS09840
gene id: 679901:MZHIL_RS09840
uniprot id: F7XKT1
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS04355
gene id: 679901:MZHIL_RS04355
uniprot id: F7XL12
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

679901:MZHIL RS03615
gene id: 679901:MZHIL_RS03615
uniprot id: F7XKA7
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

679901:MZHIL RS05195
gene id: 679901:MZHIL_RS05195
uniprot id: F7XLV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG.
messages: Cytoplasm

679901:MZHIL RS07945
gene id: 679901:MZHIL_RS07945
uniprot id: F7XPJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

679901:MZHIL RS02840
gene id: 679901:MZHIL_RS02840
uniprot id: F7XQ63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

679901:MZHIL RS08720
gene id: 679901:MZHIL_RS08720
uniprot id: F7XQA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

679901:MZHIL RS01095
gene id: 679901:MZHIL_RS01095
uniprot id: F7XNJ0
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

679901:MZHIL RS01345
gene id: 679901:MZHIL_RS01345
uniprot id: F7XNN0
names: Function
names: Similarity
messages: Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

679901:MZHIL RS04030
gene id: 679901:MZHIL_RS04030
uniprot id: F7XLH4
names: Similarity
messages: Belongs to the ZPR1 family.

679901:MZHIL RS07125
gene id: 679901:MZHIL_RS07125
uniprot id: F7XNQ9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

679901:MZHIL RS02705
gene id: 679901:MZHIL_RS02705
uniprot id: F7XQ37
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

679901:MZHIL RS03500
gene id: 679901:MZHIL_RS03500
uniprot id: F7XK89
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

679901:MZHIL RS05235
gene id: 679901:MZHIL_RS05235
uniprot id: F7XLW2
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS07755
gene id: 679901:MZHIL_RS07755
uniprot id: F7XP85
names: Similarity
messages: Belongs to the peptidase C56 family.

679901:MZHIL RS08150
gene id: 679901:MZHIL_RS08150
uniprot id: F7XPM5
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

679901:MZHIL RS04190
gene id: 679901:MZHIL_RS04190
uniprot id: F7XKY5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

679901:MZHIL RS05275
gene id: 679901:MZHIL_RS05275
uniprot id: F7XLX0
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

679901:MZHIL RS01655
gene id: 679901:MZHIL_RS01655
uniprot id: F7XP03
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

679901:MZHIL RS06215
gene id: 679901:MZHIL_RS06215
uniprot id: F7XLU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

679901:MZHIL RS01910
gene id: 679901:MZHIL_RS01910
uniprot id: F7XPC0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

679901:MZHIL RS05915
gene id: 679901:MZHIL_RS05915
uniprot id: F7XMC0
names: Function
messages: Probably involved in the biogenesis of the ribosome.

679901:MZHIL RS04660
gene id: 679901:MZHIL_RS04660
uniprot id: F7XLC2
names: Similarity
messages: Belongs to the HypD family.

679901:MZHIL RS02410
gene id: 679901:MZHIL_RS02410
uniprot id: F7XLE8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS02845
gene id: 679901:MZHIL_RS02845
uniprot id: F7XQ64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

679901:MZHIL RS05260
gene id: 679901:MZHIL_RS05260
uniprot id: F7XLW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

679901:MZHIL RS03815
gene id: 679901:MZHIL_RS03815
uniprot id: F7XKL2
names: Similarity
messages: Belongs to the AOR/FOR family.

679901:MZHIL RS01900
gene id: 679901:MZHIL_RS01900
uniprot id: F7XPB7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

679901:MZHIL RS00870
gene id: 679901:MZHIL_RS00870
uniprot id: F7XN88
names: Similarity
messages: Belongs to the AAA ATPase family.

679901:MZHIL RS00915
gene id: 679901:MZHIL_RS00915
uniprot id: F7XN97
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

679901:MZHIL RS06065
gene id: 679901:MZHIL_RS06065
uniprot id: F7XMN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

679901:MZHIL RS09495
gene id: 679901:MZHIL_RS09495
uniprot id: F7XKF5
names: Similarity
messages: Belongs to the UPF0288 family.

679901:MZHIL RS04555
gene id: 679901:MZHIL_RS04555
uniprot id: F7XLA1
names: Similarity
messages: Belongs to the UPF0280 family.

679901:MZHIL RS04135
gene id: 679901:MZHIL_RS04135
uniprot id: F7XKX5
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

679901:MZHIL RS00455
gene id: 679901:MZHIL_RS00455
uniprot id: F7XMV1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

679901:MZHIL RS02575
gene id: 679901:MZHIL_RS02575
uniprot id: F7XQ13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

679901:MZHIL RS00030
gene id: 679901:MZHIL_RS00030
uniprot id: F7XMG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

679901:MZHIL RS07885
gene id: 679901:MZHIL_RS07885
uniprot id: F7XPI2
names: Cofactor
messages: Binds 1 zinc ion per subunit.

679901:MZHIL RS06130
gene id: 679901:MZHIL_RS06130
uniprot id: F7XLT8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

679901:MZHIL RS09255
gene id: 679901:MZHIL_RS09255
uniprot id: F7XQS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

679901:MZHIL RS08330
gene id: 679901:MZHIL_RS08330
uniprot id: F7XPX1
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

679901:MZHIL RS08455
gene id: 679901:MZHIL_RS08455
uniprot id: F7XM61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

679901:MZHIL RS08665
gene id: 679901:MZHIL_RS08665
uniprot id: F7XQ97
names: Similarity
messages: Belongs to the MtrH family.

679901:MZHIL RS09595
gene id: 679901:MZHIL_RS09595
uniprot id: F7XKH0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS03865
gene id: 679901:MZHIL_RS03865
uniprot id: F7XKM0
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

679901:MZHIL RS02735
gene id: 679901:MZHIL_RS02735
uniprot id: F7XQ43
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

679901:MZHIL RS01975
gene id: 679901:MZHIL_RS01975
uniprot id: F7XPD3
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

679901:MZHIL RS03905
gene id: 679901:MZHIL_RS03905
uniprot id: F7XKM7
names: Similarity
messages: Belongs to the TlyA family.

679901:MZHIL RS08185
gene id: 679901:MZHIL_RS08185
uniprot id: F7XPU4
names: Subcellular Location Annotation
messages: Cell membrane

679901:MZHIL RS05935
gene id: 679901:MZHIL_RS05935
uniprot id: F7XML1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

679901:MZHIL RS02010
gene id: 679901:MZHIL_RS02010
uniprot id: F7XPD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

679901:MZHIL RS04970
gene id: 679901:MZHIL_RS04970
uniprot id: F7XLL9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679901:MZHIL RS05135
gene id: 679901:MZHIL_RS05135
uniprot id: F7XLP2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

679901:MZHIL RS03490
gene id: 679901:MZHIL_RS03490
uniprot id: F7XK87
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

679901:MZHIL RS00940
gene id: 679901:MZHIL_RS00940
uniprot id: F7XNA2
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

679901:MZHIL RS09250
gene id: 679901:MZHIL_RS09250
uniprot id: F7XQS1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS06440
gene id: 679901:MZHIL_RS06440
uniprot id: F7XN16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

679901:MZHIL RS04345
gene id: 679901:MZHIL_RS04345
uniprot id: F7XL10
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

679901:MZHIL RS06230
gene id: 679901:MZHIL_RS06230
uniprot id: F7XMR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

679901:MZHIL RS02200
gene id: 679901:MZHIL_RS02200
uniprot id: F7XPN7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

679901:MZHIL RS09235
gene id: 679901:MZHIL_RS09235
uniprot id: F7XMD4
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS00880
gene id: 679901:MZHIL_RS00880
uniprot id: F7XN90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

679901:MZHIL RS00485
gene id: 679901:MZHIL_RS00485
uniprot id: F7XMV5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

679901:MZHIL RS02555
gene id: 679901:MZHIL_RS02555
uniprot id: F7XPU3
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine.

679901:MZHIL RS06345
gene id: 679901:MZHIL_RS06345
uniprot id: F7XMZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

679901:MZHIL RS09115
gene id: 679901:MZHIL_RS09115
uniprot id: F7XMD1
names: Similarity
messages: Belongs to the UPF0215 family.

679901:MZHIL RS01605
gene id: 679901:MZHIL_RS01605
uniprot id: F7XNZ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

679901:MZHIL RS00800
gene id: 679901:MZHIL_RS00800
uniprot id: F7XN76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

679901:MZHIL RS09905
gene id: 679901:MZHIL_RS09905
uniprot id: F7XKZ2
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

679901:MZHIL RS09925
gene id: 679901:MZHIL_RS09925
uniprot id: F7XKU4
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

679901:MZHIL RS04955
gene id: 679901:MZHIL_RS04955
uniprot id: F7XLL6
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS09940
gene id: 679901:MZHIL_RS09940
uniprot id: F7XKU6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS02600
gene id: 679901:MZHIL_RS02600
uniprot id: F7XQ18
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

679901:MZHIL RS08470
gene id: 679901:MZHIL_RS08470
uniprot id: F7XPZ4
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

679901:MZHIL RS07150
gene id: 679901:MZHIL_RS07150
uniprot id: F7XNR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

679901:MZHIL RS05315
gene id: 679901:MZHIL_RS05315
uniprot id: F7XLX6
names: Similarity
messages: Belongs to the malic enzymes family.

679901:MZHIL RS02215
gene id: 679901:MZHIL_RS02215
uniprot id: F7XPP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

679901:MZHIL RS04775
gene id: 679901:MZHIL_RS04775
uniprot id: F7XLE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 2 family.
messages: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

679901:MZHIL RS05285
gene id: 679901:MZHIL_RS05285
uniprot id: F7XLX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

679901:MZHIL RS05405
gene id: 679901:MZHIL_RS05405
uniprot id: F7XLZ4
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

679901:MZHIL RS00325
gene id: 679901:MZHIL_RS00325
uniprot id: F7XMS5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS09695
gene id: 679901:MZHIL_RS09695
uniprot id: F7XME8
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

679901:MZHIL RS08415
gene id: 679901:MZHIL_RS08415
uniprot id: F7XPY7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS04225
gene id: 679901:MZHIL_RS04225
uniprot id: F7XKZ2
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

679901:MZHIL RS03175
gene id: 679901:MZHIL_RS03175
uniprot id: F7XQI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

679901:MZHIL RS10055
gene id: 679901:MZHIL_RS10055
uniprot id: F7XKW3
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

679901:MZHIL RS05795
gene id: 679901:MZHIL_RS05795
uniprot id: F7XMA5
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

679901:MZHIL RS00945
gene id: 679901:MZHIL_RS00945
uniprot id: F7XNA3
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

679901:MZHIL RS02140
gene id: 679901:MZHIL_RS02140
uniprot id: F7XPG6
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

679901:MZHIL RS04295
gene id: 679901:MZHIL_RS04295
uniprot id: F7XL04
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

679901:MZHIL RS01985
gene id: 679901:MZHIL_RS01985
uniprot id: F7XPD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

679901:MZHIL RS06985
gene id: 679901:MZHIL_RS06985
uniprot id: F7XNH4
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

679901:MZHIL RS09850
gene id: 679901:MZHIL_RS09850
uniprot id: F7XKT2
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

679901:MZHIL RS01905
gene id: 679901:MZHIL_RS01905
uniprot id: F7XPB9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

679901:MZHIL RS08640
gene id: 679901:MZHIL_RS08640
uniprot id: F7XQ92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

679901:MZHIL RS04470
gene id: 679901:MZHIL_RS04470
uniprot id: F7XL83
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS07055
gene id: 679901:MZHIL_RS07055
uniprot id: F7XNI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

679901:MZHIL RS02470
gene id: 679901:MZHIL_RS02470
uniprot id: F7XPT2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

679901:MZHIL RS03845
gene id: 679901:MZHIL_RS03845
uniprot id: F7XKL8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

679901:MZHIL RS10010
gene id: 679901:MZHIL_RS10010
uniprot id: F7XKV8
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

679901:MZHIL RS05620
gene id: 679901:MZHIL_RS05620
uniprot id: F7XM77
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS02465
gene id: 679901:MZHIL_RS02465
uniprot id: F7XPT1
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

679901:MZHIL RS05100
gene id: 679901:MZHIL_RS05100
uniprot id: F7XLR0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS07520
gene id: 679901:MZHIL_RS07520
uniprot id: F7XP45
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS04205
gene id: 679901:MZHIL_RS04205
uniprot id: F7XKY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

679901:MZHIL RS08465
gene id: 679901:MZHIL_RS08465
uniprot id: F7XPZ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

679901:MZHIL RS01025
gene id: 679901:MZHIL_RS01025
uniprot id: F7XNB5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

679901:MZHIL RS04285
gene id: 679901:MZHIL_RS04285
uniprot id: F7XL03
names: Similarity
messages: Belongs to the FBPase class 2 family.

679901:MZHIL RS01235
gene id: 679901:MZHIL_RS01235
uniprot id: F7XNL3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

679901:MZHIL RS07605
gene id: 679901:MZHIL_RS07605
uniprot id: F7XP61
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

679901:MZHIL RS09875
gene id: 679901:MZHIL_RS09875
uniprot id: F7XKT6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

679901:MZHIL RS06800
gene id: 679901:MZHIL_RS06800
uniprot id: F7XNE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

679901:MZHIL RS04975
gene id: 679901:MZHIL_RS04975
uniprot id: F7XLM0
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS05145
gene id: 679901:MZHIL_RS05145
uniprot id: F7XLP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

679901:MZHIL RS06225
gene id: 679901:MZHIL_RS06225
uniprot id: F7XLU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

679901:MZHIL RS04280
gene id: 679901:MZHIL_RS04280
uniprot id: F7XLH7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

679901:MZHIL RS07450
gene id: 679901:MZHIL_RS07450
uniprot id: F7XP30
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS09780
gene id: 679901:MZHIL_RS09780
uniprot id: F7XKR9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679901:MZHIL RS02395
gene id: 679901:MZHIL_RS02395
uniprot id: F7XPS0
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

679901:MZHIL RS06145
gene id: 679901:MZHIL_RS06145
uniprot id: F7XMP6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

679901:MZHIL RS06235
gene id: 679901:MZHIL_RS06235
uniprot id: F7XMR1
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

679901:MZHIL RS01645
gene id: 679901:MZHIL_RS01645
uniprot id: F7XL72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

679901:MZHIL RS01560
gene id: 679901:MZHIL_RS01560
uniprot id: F7XNY3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679901:MZHIL RS04915
gene id: 679901:MZHIL_RS04915
uniprot id: F7XLK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

679901:MZHIL RS03945
gene id: 679901:MZHIL_RS03945
uniprot id: F7XLH1
names: Similarity
messages: Belongs to the peptidase U62 family.

679901:MZHIL RS02000
gene id: 679901:MZHIL_RS02000
uniprot id: F7XPD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

679901:MZHIL RS00240
gene id: 679901:MZHIL_RS00240
uniprot id: F7XMJ9
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

679901:MZHIL RS06385
gene id: 679901:MZHIL_RS06385
uniprot id: F7XN06
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679901:MZHIL RS05140
gene id: 679901:MZHIL_RS05140
uniprot id: F7XLP3
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

679901:MZHIL RS04520
gene id: 679901:MZHIL_RS04520
uniprot id: F7XL94
names: Caution
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS01425
gene id: 679901:MZHIL_RS01425
uniprot id: F7XNP3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

679901:MZHIL RS02455
gene id: 679901:MZHIL_RS02455
uniprot id: F7XPS9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

679901:MZHIL RS03365
gene id: 679901:MZHIL_RS03365
uniprot id: F7XK61
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS01340
gene id: 679901:MZHIL_RS01340
uniprot id: F7XL68
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS09210
gene id: 679901:MZHIL_RS09210
uniprot id: F7XQR7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

679901:MZHIL RS09720
gene id: 679901:MZHIL_RS09720
uniprot id: F7XKQ7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

679901:MZHIL RS06320
gene id: 679901:MZHIL_RS06320
uniprot id: F7XMZ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

679901:MZHIL RS03975
gene id: 679901:MZHIL_RS03975
uniprot id: F7XKN6
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS01150
gene id: 679901:MZHIL_RS01150
uniprot id: F7XNK1
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

679901:MZHIL RS07890
gene id: 679901:MZHIL_RS07890
uniprot id: F7XPI3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS05775
gene id: 679901:MZHIL_RS05775
uniprot id: F7XLS5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

679901:MZHIL RS05020
gene id: 679901:MZHIL_RS05020
uniprot id: F7XLM6
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

679901:MZHIL RS07505
gene id: 679901:MZHIL_RS07505
uniprot id: F7XP42
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

679901:MZHIL RS04255
gene id: 679901:MZHIL_RS04255
uniprot id: F7XKZ8
names: Similarity
messages: Belongs to the UPF0237 family.

679901:MZHIL RS02545
gene id: 679901:MZHIL_RS02545
uniprot id: F7XPU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

679901:MZHIL RS09305
gene id: 679901:MZHIL_RS09305
uniprot id: F7XQS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

679901:MZHIL RS06120
gene id: 679901:MZHIL_RS06120
uniprot id: F7XLT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

679901:MZHIL RS02740
gene id: 679901:MZHIL_RS02740
uniprot id: F7XQ44
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

679901:MZHIL RS02015
gene id: 679901:MZHIL_RS02015
uniprot id: F7XPE0
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS05905
gene id: 679901:MZHIL_RS05905
uniprot id: F7XMB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

679901:MZHIL RS05685
gene id: 679901:MZHIL_RS05685
uniprot id: F7XM90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

679901:MZHIL RS05070
gene id: 679901:MZHIL_RS05070
uniprot id: F7XLN5
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

679901:MZHIL RS05930
gene id: 679901:MZHIL_RS05930
uniprot id: F7XML0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

679901:MZHIL RS06335
gene id: 679901:MZHIL_RS06335
uniprot id: F7XMZ5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

679901:MZHIL RS07575
gene id: 679901:MZHIL_RS07575
uniprot id: F7XP54
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679901:MZHIL RS02245
gene id: 679901:MZHIL_RS02245
uniprot id: F7XPP6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

679901:MZHIL RS08940
gene id: 679901:MZHIL_RS08940
uniprot id: F7XQL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

679901:MZHIL RS01880
gene id: 679901:MZHIL_RS01880
uniprot id: F7XPB4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

679901:MZHIL RS06255
gene id: 679901:MZHIL_RS06255
uniprot id: F7XMR4
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS09675
gene id: 679901:MZHIL_RS09675
uniprot id: F7XKI7
names: Similarity
messages: Belongs to the LarC family.

679901:MZHIL RS04260
gene id: 679901:MZHIL_RS04260
uniprot id: F7XKZ9
names: Similarity
messages: Belongs to the UPF0210 family.

679901:MZHIL RS02725
gene id: 679901:MZHIL_RS02725
uniprot id: F7XQ41
names: Similarity
messages: Belongs to the PDCD5 family.

679901:MZHIL RS08245
gene id: 679901:MZHIL_RS08245
uniprot id: F7XPV6
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS09975
gene id: 679901:MZHIL_RS09975
uniprot id: F7XKV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

679901:MZHIL RS05540
gene id: 679901:MZHIL_RS05540
uniprot id: F7XM14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

679901:MZHIL RS06370
gene id: 679901:MZHIL_RS06370
uniprot id: F7XN03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

679901:MZHIL RS00810
gene id: 679901:MZHIL_RS00810
uniprot id: F7XN78
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS04335
gene id: 679901:MZHIL_RS04335
uniprot id: F7XL09
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

679901:MZHIL RS10175
gene id: 679901:MZHIL_RS10175
uniprot id: F7XL45
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

679901:MZHIL RS04720
gene id: 679901:MZHIL_RS04720
uniprot id: F7XLD2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

679901:MZHIL RS06920
gene id: 679901:MZHIL_RS06920
uniprot id: F7XNG5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

679901:MZHIL RS04685
gene id: 679901:MZHIL_RS04685
uniprot id: F7XLC6
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS05605
gene id: 679901:MZHIL_RS05605
uniprot id: F7XM74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

679901:MZHIL RS01710
gene id: 679901:MZHIL_RS01710
uniprot id: F7XP11
names: Similarity
messages: Belongs to the HdrC family.

679901:MZHIL RS06865
gene id: 679901:MZHIL_RS06865
uniprot id: F7XM19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

679901:MZHIL RS00230
gene id: 679901:MZHIL_RS00230
uniprot id: F7XMJ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

679901:MZHIL RS02420
gene id: 679901:MZHIL_RS02420
uniprot id: F7XLE9
names: Similarity
messages: Belongs to the UPF0179 family.

679901:MZHIL RS10170
gene id: 679901:MZHIL_RS10170
uniprot id: F7XL44
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

679901:MZHIL RS05240
gene id: 679901:MZHIL_RS05240
uniprot id: F7XLW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

679901:MZHIL RS00545
gene id: 679901:MZHIL_RS00545
uniprot id: F7XMW7
names: Similarity
messages: Belongs to the gamma-class carbonic anhydrase family.

679901:MZHIL RS09650
gene id: 679901:MZHIL_RS09650
uniprot id: F7XKI1
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

679901:MZHIL RS09385
gene id: 679901:MZHIL_RS09385
uniprot id: F7XKD4
names: Similarity
messages: Belongs to the peptidase S49 family.

679901:MZHIL RS08310
gene id: 679901:MZHIL_RS08310
uniprot id: F7XPW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

679901:MZHIL RS09080
gene id: 679901:MZHIL_RS09080
uniprot id: F7XQP3
names: Similarity
messages: Belongs to the UPF0292 family.

679901:MZHIL RS00305
gene id: 679901:MZHIL_RS00305
uniprot id: F7XMS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

679901:MZHIL RS04365
gene id: 679901:MZHIL_RS04365
uniprot id: F7XL13
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

679901:MZHIL RS06245
gene id: 679901:MZHIL_RS06245
uniprot id: F7XMR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

679901:MZHIL RS01300
gene id: 679901:MZHIL_RS01300
uniprot id: F7XNM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

679901:MZHIL RS02935
gene id: 679901:MZHIL_RS02935
uniprot id: F7XQE2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

679901:MZHIL RS00555
gene id: 679901:MZHIL_RS00555
uniprot id: F7XL54
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

679901:MZHIL RS00145
gene id: 679901:MZHIL_RS00145
uniprot id: F7XMI7
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

679901:MZHIL RS03610
gene id: 679901:MZHIL_RS03610
uniprot id: F7XKA6
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

679901:MZHIL RS01105
gene id: 679901:MZHIL_RS01105
uniprot id: F7XNJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

679901:MZHIL RS08505
gene id: 679901:MZHIL_RS08505
uniprot id: F7XQ01
names: Subunit
messages: Homotetramer.

679901:MZHIL RS06250
gene id: 679901:MZHIL_RS06250
uniprot id: F7XLU3
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

679901:MZHIL RS03805
gene id: 679901:MZHIL_RS03805
uniprot id: F7XKL0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS01405
gene id: 679901:MZHIL_RS01405
uniprot id: F7XNP0
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

679901:MZHIL RS08110
gene id: 679901:MZHIL_RS08110
uniprot id: F7XM52
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

679901:MZHIL RS08950
gene id: 679901:MZHIL_RS08950
uniprot id: F7XQL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

679901:MZHIL RS01315
gene id: 679901:MZHIL_RS01315
uniprot id: F7XL67
names: Similarity
messages: Belongs to the UPF0147 family.

679901:MZHIL RS00275
gene id: 679901:MZHIL_RS00275
uniprot id: F7XMK4
names: Similarity
messages: Belongs to the band 7/mec-2 family.

679901:MZHIL RS07425
gene id: 679901:MZHIL_RS07425
uniprot id: F7XNV9
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

679901:MZHIL RS07990
gene id: 679901:MZHIL_RS07990
uniprot id: F7XPK2
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS02580
gene id: 679901:MZHIL_RS02580
uniprot id: F7XQ14
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

679901:MZHIL RS02290
gene id: 679901:MZHIL_RS02290
uniprot id: F7XPQ3
names: Similarity
messages: Belongs to the class-I fumarase family.

679901:MZHIL RS05965
gene id: 679901:MZHIL_RS05965
uniprot id: F7XML7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

679901:MZHIL RS02020
gene id: 679901:MZHIL_RS02020
uniprot id: F7XPE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane

679901:MZHIL RS06750
gene id: 679901:MZHIL_RS06750
uniprot id: F7XND3
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

679901:MZHIL RS00715
gene id: 679901:MZHIL_RS00715
uniprot id: F7XN57
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

679901:MZHIL RS06810
gene id: 679901:MZHIL_RS06810
uniprot id: F7XNE5
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS05750
gene id: 679901:MZHIL_RS05750
uniprot id: F7XM98
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.

679901:MZHIL RS06855
gene id: 679901:MZHIL_RS06855
uniprot id: F7XNF4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

679901:MZHIL RS06165
gene id: 679901:MZHIL_RS06165
uniprot id: F7XMQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

679901:MZHIL RS00210
gene id: 679901:MZHIL_RS00210
uniprot id: F7XMJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

679901:MZHIL RS01750
gene id: 679901:MZHIL_RS01750
uniprot id: F7XP19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

679901:MZHIL RS00130
gene id: 679901:MZHIL_RS00130
uniprot id: F7XMI4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

679901:MZHIL RS03840
gene id: 679901:MZHIL_RS03840
uniprot id: F7XKL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

679901:MZHIL RS06030
gene id: 679901:MZHIL_RS06030
uniprot id: F7XMN0
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS01130
gene id: 679901:MZHIL_RS01130
uniprot id: F7XNJ7
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

679901:MZHIL RS08105
gene id: 679901:MZHIL_RS08105
uniprot id: F7XPL8
names: Function
messages: Part of a potassium transport system.

679901:MZHIL RS08235
gene id: 679901:MZHIL_RS08235
uniprot id: F7XPV4
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

679901:MZHIL RS02755
gene id: 679901:MZHIL_RS02755
uniprot id: F7XQ47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

679901:MZHIL RS09900
gene id: 679901:MZHIL_RS09900
uniprot id: F7XMF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

679901:MZHIL RS01915
gene id: 679901:MZHIL_RS01915
uniprot id: F7XPC1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

679901:MZHIL RS07360
gene id: 679901:MZHIL_RS07360
uniprot id: F7XNU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

679901:MZHIL RS07570
gene id: 679901:MZHIL_RS07570
uniprot id: F7XP53
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

679901:MZHIL RS08210
gene id: 679901:MZHIL_RS08210
uniprot id: F7XPU9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS06195
gene id: 679901:MZHIL_RS06195
uniprot id: F7XMQ6
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

679901:MZHIL RS00260
gene id: 679901:MZHIL_RS00260
uniprot id: F7XMK2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

679901:MZHIL RS02535
gene id: 679901:MZHIL_RS02535
uniprot id: F7XPT9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS05815
gene id: 679901:MZHIL_RS05815
uniprot id: F7XMA7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

679901:MZHIL RS05435
gene id: 679901:MZHIL_RS05435
uniprot id: F7XLZ8
names: Similarity
messages: Belongs to the UPF0047 family.

679901:MZHIL RS07525
gene id: 679901:MZHIL_RS07525
uniprot id: F7XP46
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

679901:MZHIL RS01960
gene id: 679901:MZHIL_RS01960
uniprot id: F7XPD0
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

679901:MZHIL RS01500
gene id: 679901:MZHIL_RS01500
uniprot id: F7XNX2
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

679901:MZHIL RS04050
gene id: 679901:MZHIL_RS04050
uniprot id: F7XKP8
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

679901:MZHIL RS05115
gene id: 679901:MZHIL_RS05115
uniprot id: F7XLP0
names: Similarity
messages: Belongs to the MEMO1 family.

679901:MZHIL RS03180
gene id: 679901:MZHIL_RS03180
uniprot id: F7XQI8
names: Similarity
messages: Belongs to the GARS family.

679901:MZHIL RS08060
gene id: 679901:MZHIL_RS08060
uniprot id: F7XPL1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

679901:MZHIL RS08250
gene id: 679901:MZHIL_RS08250
uniprot id: F7XPV7
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

679901:MZHIL RS00490
gene id: 679901:MZHIL_RS00490
uniprot id: F7XMV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

679901:MZHIL RS07635
gene id: 679901:MZHIL_RS07635
uniprot id: F7XP68
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS08325
gene id: 679901:MZHIL_RS08325
uniprot id: F7XPX0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

679901:MZHIL RS08960
gene id: 679901:MZHIL_RS08960
uniprot id: F7XQL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ModE family.
messages: Membrane

679901:MZHIL RS06900
gene id: 679901:MZHIL_RS06900
uniprot id: F7XNG2
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

679901:MZHIL RS10050
gene id: 679901:MZHIL_RS10050
uniprot id: F7XMF7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

679901:MZHIL RS02610
gene id: 679901:MZHIL_RS02610
uniprot id: F7XQ20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

679901:MZHIL RS02590
gene id: 679901:MZHIL_RS02590
uniprot id: F7XQ16
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

679901:MZHIL RS09750
gene id: 679901:MZHIL_RS09750
uniprot id: F7XKR3
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

679901:MZHIL RS09930
gene id: 679901:MZHIL_RS09930
uniprot id: F7XKU5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS05530
gene id: 679901:MZHIL_RS05530
uniprot id: F7XM12
names: Similarity
messages: Belongs to the SfsA family.

679901:MZHIL RS09525
gene id: 679901:MZHIL_RS09525
uniprot id: F7XKF9
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

679901:MZHIL RS08005
gene id: 679901:MZHIL_RS08005
uniprot id: F7XM46
names: Subcellular Location Annotation
messages: Membrane

679901:MZHIL RS08735
gene id: 679901:MZHIL_RS08735
uniprot id: F7XQB1
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

679901:MZHIL RS00435
gene id: 679901:MZHIL_RS00435
uniprot id: F7XMU7
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

679901:MZHIL RS08490
gene id: 679901:MZHIL_RS08490
uniprot id: F7XPZ8
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.