642492:CLOLE RS11295
gene id: 642492:CLOLE_RS11295
uniprot id: F2JRM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

642492:CLOLE RS01710
gene id: 642492:CLOLE_RS01710
uniprot id: F2JIX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS04070
gene id: 642492:CLOLE_RS04070
uniprot id: F2JPF3
names: Similarity
messages: Belongs to the class-I fumarase family.

642492:CLOLE RS11595
gene id: 642492:CLOLE_RS11595
uniprot id: F2JS74
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

642492:CLOLE RS17170
gene id: 642492:CLOLE_RS17170
uniprot id: F2JRS6
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

642492:CLOLE RS12545
gene id: 642492:CLOLE_RS12545
uniprot id: F2JHG3
names: Caution
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS11590
gene id: 642492:CLOLE_RS11590
uniprot id: F2JS73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

642492:CLOLE RS08605
gene id: 642492:CLOLE_RS08605
uniprot id: F2JLM3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS22030
gene id: 642492:CLOLE_RS22030
uniprot id: F2JP79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LPG synthase family.
messages: Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS16245
gene id: 642492:CLOLE_RS16245
uniprot id: F2JQF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS19865
gene id: 642492:CLOLE_RS19865
uniprot id: F2JKC4
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

642492:CLOLE RS10925
gene id: 642492:CLOLE_RS10925
uniprot id: F2JR23
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

642492:CLOLE RS03280
gene id: 642492:CLOLE_RS03280
uniprot id: F2JMZ8
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.
messages: Homotetramer.

642492:CLOLE RS11535
gene id: 642492:CLOLE_RS11535
uniprot id: F2JS62
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

642492:CLOLE RS18250
gene id: 642492:CLOLE_RS18250
uniprot id: F2JGX9
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS13790
gene id: 642492:CLOLE_RS13790
uniprot id: F2JK34
names: Similarity
messages: Belongs to the myoviridae tail sheath protein family.

642492:CLOLE RS12515
gene id: 642492:CLOLE_RS12515
uniprot id: F2JGV4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

642492:CLOLE RS17545
gene id: 642492:CLOLE_RS17545
uniprot id: F2JSD9
names: Similarity
messages: Belongs to the peptidase S41A family.

642492:CLOLE RS19725
gene id: 642492:CLOLE_RS19725
uniprot id: F2JK98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS09125
gene id: 642492:CLOLE_RS09125
uniprot id: F2JN66
names: Similarity
messages: Belongs to the glycosyl hydrolase 26 family.

642492:CLOLE RS01960
gene id: 642492:CLOLE_RS01960
uniprot id: F2JJQ3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

642492:CLOLE RS11570
gene id: 642492:CLOLE_RS11570
uniprot id: F2JS69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS12160
gene id: 642492:CLOLE_RS12160
uniprot id: F2JGN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

642492:CLOLE RS03695
gene id: 642492:CLOLE_RS03695
uniprot id: F2JNS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Cell membrane

642492:CLOLE RS11060
gene id: 642492:CLOLE_RS11060
uniprot id: F2JRI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

642492:CLOLE RS08355
gene id: 642492:CLOLE_RS08355
uniprot id: F2JLH3
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

642492:CLOLE RS11695
gene id: 642492:CLOLE_RS11695
uniprot id: F2JS94
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

642492:CLOLE RS03315
gene id: 642492:CLOLE_RS03315
uniprot id: F2JN05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

642492:CLOLE RS02375
gene id: 642492:CLOLE_RS02375
uniprot id: F2JKL6
names: Similarity
messages: Belongs to the P(II) protein family.

642492:CLOLE RS20510
gene id: 642492:CLOLE_RS20510
uniprot id: F2JLZ0
names: Similarity
messages: Belongs to the EutP/PduV family.

642492:CLOLE RS00345
gene id: 642492:CLOLE_RS00345
uniprot id: F2JGC1
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS00735
gene id: 642492:CLOLE_RS00735
uniprot id: F2JH54
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.

642492:CLOLE RS19105
gene id: 642492:CLOLE_RS19105
uniprot id: F2JIM1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

642492:CLOLE RS10080
gene id: 642492:CLOLE_RS10080
uniprot id: F2JPP9
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS16615
gene id: 642492:CLOLE_RS16615
uniprot id: F2JQN3
names: Similarity
messages: Belongs to the glycosyl hydrolase.

642492:CLOLE RS19135
gene id: 642492:CLOLE_RS19135
uniprot id: F2JIM7
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

642492:CLOLE RS18035
gene id: 642492:CLOLE_RS18035
uniprot id: F2JT56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

642492:CLOLE RS07200
gene id: 642492:CLOLE_RS07200
uniprot id: F2JI99
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

642492:CLOLE RS15945
gene id: 642492:CLOLE_RS15945
uniprot id: F2JPU9
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS10745
gene id: 642492:CLOLE_RS10745
uniprot id: F2JQY6
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

642492:CLOLE RS01180
gene id: 642492:CLOLE_RS01180
uniprot id: F2JI01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: In the C-terminal section; belongs to the OsmX family.
messages: In the N-terminal section; belongs to the binding-protein-dependent transport system permease family.
messages: Membrane

642492:CLOLE RS19140
gene id: 642492:CLOLE_RS19140
uniprot id: F2JIM8
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS20180
gene id: 642492:CLOLE_RS20180
uniprot id: F2JL59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

642492:CLOLE RS20785
gene id: 642492:CLOLE_RS20785
uniprot id: F2JM40
names: Similarity
names: Subunit
messages: Belongs to the RNase H family.
messages: Monomer.

642492:CLOLE RS21360
gene id: 642492:CLOLE_RS21360
uniprot id: F2JNP4
names: Similarity
messages: Belongs to the ParB family.

642492:CLOLE RS10815
gene id: 642492:CLOLE_RS10815
uniprot id: F2JR00
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

642492:CLOLE RS17835
gene id: 642492:CLOLE_RS17835
uniprot id: F2JT16
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

642492:CLOLE RS08175
gene id: 642492:CLOLE_RS08175
uniprot id: F2JKS5
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS16035
gene id: 642492:CLOLE_RS16035
uniprot id: F2JPW8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

642492:CLOLE RS06680
gene id: 642492:CLOLE_RS06680
uniprot id: F2JHC6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

642492:CLOLE RS06650
gene id: 642492:CLOLE_RS06650
uniprot id: F2JHB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

642492:CLOLE RS19005
gene id: 642492:CLOLE_RS19005
uniprot id: F2JIK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

642492:CLOLE RS12975
gene id: 642492:CLOLE_RS12975
uniprot id: F2JIB9
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS03335
gene id: 642492:CLOLE_RS03335
uniprot id: F2JN09
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.

642492:CLOLE RS01100
gene id: 642492:CLOLE_RS01100
uniprot id: F2JHY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS20490
gene id: 642492:CLOLE_RS20490
uniprot id: F2JLY6
names: Subcellular Location Annotation
messages: Bacterial microcompartment

642492:CLOLE RS11065
gene id: 642492:CLOLE_RS11065
uniprot id: F2JRI6
names: Similarity
messages: Belongs to the glutamine synthetase family.

642492:CLOLE RS21250
gene id: 642492:CLOLE_RS21250
uniprot id: F2JNM1
names: Similarity
messages: Belongs to the glutamine synthetase family.

642492:CLOLE RS15210
gene id: 642492:CLOLE_RS15210
uniprot id: F2JNG0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

642492:CLOLE RS19060
gene id: 642492:CLOLE_RS19060
uniprot id: F2JIL2
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

642492:CLOLE RS21375
gene id: 642492:CLOLE_RS21375
uniprot id: F2JNP7
names: Similarity
messages: Belongs to the ParB family.

642492:CLOLE RS14655
gene id: 642492:CLOLE_RS14655
uniprot id: F2JLW0
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS15265
gene id: 642492:CLOLE_RS15265
uniprot id: F2JNH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

642492:CLOLE RS14360
gene id: 642492:CLOLE_RS14360
uniprot id: F2JLP8
names: Similarity
messages: Belongs to the YciI family.

642492:CLOLE RS01680
gene id: 642492:CLOLE_RS01680
uniprot id: F2JIW9
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS03525
gene id: 642492:CLOLE_RS03525
uniprot id: F2JN47
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

642492:CLOLE RS06460
gene id: 642492:CLOLE_RS06460
uniprot id: F2JGM2
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

642492:CLOLE RS19620
gene id: 642492:CLOLE_RS19620
uniprot id: F2JJJ8
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS17895
gene id: 642492:CLOLE_RS17895
uniprot id: F2JT28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

642492:CLOLE RS02385
gene id: 642492:CLOLE_RS02385
uniprot id: F2JKL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS17705
gene id: 642492:CLOLE_RS17705
uniprot id: F2JSH1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

642492:CLOLE RS10565
gene id: 642492:CLOLE_RS10565
uniprot id: F2JQE7
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

642492:CLOLE RS02125
gene id: 642492:CLOLE_RS02125
uniprot id: F2JKG7
names: Similarity
messages: Belongs to the peptidase M20A family.

642492:CLOLE RS16980
gene id: 642492:CLOLE_RS16980
uniprot id: F2JR92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

642492:CLOLE RS08890
gene id: 642492:CLOLE_RS08890
uniprot id: F2JMF3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

642492:CLOLE RS02705
gene id: 642492:CLOLE_RS02705
uniprot id: F2JLE4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flotillin-like FloA family.
messages: Cell membrane
messages: Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.
messages: Homooligomerizes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

642492:CLOLE RS12915
gene id: 642492:CLOLE_RS12915
uniprot id: F2JIA7
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS05760
gene id: 642492:CLOLE_RS05760
uniprot id: F2JS32
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

642492:CLOLE RS12435
gene id: 642492:CLOLE_RS12435
uniprot id: F2JGT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

642492:CLOLE RS09225
gene id: 642492:CLOLE_RS09225
uniprot id: F2JN87
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS10515
gene id: 642492:CLOLE_RS10515
uniprot id: F2JQD7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

642492:CLOLE RS04650
gene id: 642492:CLOLE_RS04650
uniprot id: F2JQ79
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

642492:CLOLE RS23580
gene id: 642492:CLOLE_RS23580
uniprot id: F2JGM0
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS19880
gene id: 642492:CLOLE_RS19880
uniprot id: F2JKC7
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS17825
gene id: 642492:CLOLE_RS17825
uniprot id: F2JT14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

642492:CLOLE RS16940
gene id: 642492:CLOLE_RS16940
uniprot id: F2JR84
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

642492:CLOLE RS14075
gene id: 642492:CLOLE_RS14075
uniprot id: F2JKX8
names: Similarity
messages: Belongs to the EamA transporter family.

642492:CLOLE RS20465
gene id: 642492:CLOLE_RS20465
uniprot id: F2JLY1
names: Function
names: Similarity
messages: Belongs to the PduL family.
messages: Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate.

642492:CLOLE RS03700
gene id: 642492:CLOLE_RS03700
uniprot id: F2JNS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.

642492:CLOLE RS01470
gene id: 642492:CLOLE_RS01470
uniprot id: F2JIS9
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

642492:CLOLE RS09790
gene id: 642492:CLOLE_RS09790
uniprot id: F2JP43
names: Similarity
messages: Belongs to the peptidase C40 family.

642492:CLOLE RS18760
gene id: 642492:CLOLE_RS18760
uniprot id: F2JHS8
names: Similarity
messages: Belongs to the WXG100 family.

642492:CLOLE RS00140
gene id: 642492:CLOLE_RS00140
uniprot id: F2JSJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

642492:CLOLE RS07030
gene id: 642492:CLOLE_RS07030
uniprot id: F2JI64
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

642492:CLOLE RS07525
gene id: 642492:CLOLE_RS07525
uniprot id: F2JJ34
names: Similarity
messages: Belongs to the SAICAR synthetase family.

642492:CLOLE RS03770
gene id: 642492:CLOLE_RS03770
uniprot id: F2JNU0
names: Similarity
messages: Belongs to the TrpF family.

642492:CLOLE RS12655
gene id: 642492:CLOLE_RS12655
uniprot id: F2JHI4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class U subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.

642492:CLOLE RS14320
gene id: 642492:CLOLE_RS14320
uniprot id: F2JL25
names: Similarity
messages: Belongs to the type IA topoisomerase family.

642492:CLOLE RS13045
gene id: 642492:CLOLE_RS13045
uniprot id: F2JID3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

642492:CLOLE RS04085
gene id: 642492:CLOLE_RS04085
uniprot id: F2JPF6
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

642492:CLOLE RS14780
gene id: 642492:CLOLE_RS14780
uniprot id: F2JML0
names: Similarity
messages: Belongs to the peptidase C40 family.

642492:CLOLE RS22265
gene id: 642492:CLOLE_RS22265
uniprot id: F2JGM4
names: Similarity
messages: Belongs to the transposase 11 family.

642492:CLOLE RS18160
gene id: 642492:CLOLE_RS18160
uniprot id: F2JGW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

642492:CLOLE RS15270
gene id: 642492:CLOLE_RS15270
uniprot id: F2JNH2
names: Similarity
messages: Belongs to the fabD family.

642492:CLOLE RS03095
gene id: 642492:CLOLE_RS03095
uniprot id: F2JM95
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS19265
gene id: 642492:CLOLE_RS19265
uniprot id: F2JIQ3
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

642492:CLOLE RS02485
gene id: 642492:CLOLE_RS02485
uniprot id: F2JLA9
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

642492:CLOLE RS00300
gene id: 642492:CLOLE_RS00300
uniprot id: F2JGB3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

642492:CLOLE RS03290
gene id: 642492:CLOLE_RS03290
uniprot id: F2JN00
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

642492:CLOLE RS01785
gene id: 642492:CLOLE_RS01785
uniprot id: F2JJM0
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

642492:CLOLE RS03710
gene id: 642492:CLOLE_RS03710
uniprot id: F2JNS8
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

642492:CLOLE RS04580
gene id: 642492:CLOLE_RS04580
uniprot id: F2JQ66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS03110
gene id: 642492:CLOLE_RS03110
uniprot id: F2JM98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS08625
gene id: 642492:CLOLE_RS08625
uniprot id: F2JLM7
names: Similarity
messages: Belongs to the peptidase S8 family.

642492:CLOLE RS19665
gene id: 642492:CLOLE_RS19665
uniprot id: F2JK87
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS14690
gene id: 642492:CLOLE_RS14690
uniprot id: F2JLW6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

642492:CLOLE RS11775
gene id: 642492:CLOLE_RS11775
uniprot id: F2JSB0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

642492:CLOLE RS19295
gene id: 642492:CLOLE_RS19295
uniprot id: F2JJD4
names: Similarity
messages: Belongs to the peptidase S8 family.

642492:CLOLE RS04080
gene id: 642492:CLOLE_RS04080
uniprot id: F2JPF5
names: Similarity
messages: Belongs to the peptidase S49 family.

642492:CLOLE RS02930
gene id: 642492:CLOLE_RS02930
uniprot id: F2JM64
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

642492:CLOLE RS00815
gene id: 642492:CLOLE_RS00815
uniprot id: F2JH59
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS04065
gene id: 642492:CLOLE_RS04065
uniprot id: F2JPF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

642492:CLOLE RS06525
gene id: 642492:CLOLE_RS06525
uniprot id: F2JH92
names: Similarity
messages: Belongs to the ThrE exporter (TC 2.A.79) family.

642492:CLOLE RS07010
gene id: 642492:CLOLE_RS07010
uniprot id: F2JI60
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

642492:CLOLE RS08015
gene id: 642492:CLOLE_RS08015
uniprot id: F2JKP3
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

642492:CLOLE RS00600
gene id: 642492:CLOLE_RS00600
uniprot id: F2JH40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

642492:CLOLE RS09240
gene id: 642492:CLOLE_RS09240
uniprot id: F2JN90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

642492:CLOLE RS17640
gene id: 642492:CLOLE_RS17640
uniprot id: F2JSF8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS21625
gene id: 642492:CLOLE_RS21625
uniprot id: F2JQ38
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS14830
gene id: 642492:CLOLE_RS14830
uniprot id: F2JML9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.

642492:CLOLE RS10015
gene id: 642492:CLOLE_RS10015
uniprot id: F2JPN7
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

642492:CLOLE RS18390
gene id: 642492:CLOLE_RS18390
uniprot id: F2JH09
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS10805
gene id: 642492:CLOLE_RS10805
uniprot id: F2JQZ8
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

642492:CLOLE RS10700
gene id: 642492:CLOLE_RS10700
uniprot id: F2JQX8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

642492:CLOLE RS12315
gene id: 642492:CLOLE_RS12315
uniprot id: F2JGR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

642492:CLOLE RS05860
gene id: 642492:CLOLE_RS05860
uniprot id: F2JSM3
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

642492:CLOLE RS17710
gene id: 642492:CLOLE_RS17710
uniprot id: F2JSH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

642492:CLOLE RS10725
gene id: 642492:CLOLE_RS10725
uniprot id: F2JQY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

642492:CLOLE RS14630
gene id: 642492:CLOLE_RS14630
uniprot id: F2JLV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS10710
gene id: 642492:CLOLE_RS10710
uniprot id: F2JQX9
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Autoproteolytically processed. The inactive tetrameric zymogen termed p46 autoprocesses to a smaller form termed p41, which is active only during spore germination.
messages: Belongs to the peptidase A25 family.
messages: Homotetramer.
messages: Initiates the rapid degradation of small, acid-soluble proteins during spore germination.

642492:CLOLE RS12410
gene id: 642492:CLOLE_RS12410
uniprot id: F2JGT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

642492:CLOLE RS10740
gene id: 642492:CLOLE_RS10740
uniprot id: F2JQY5
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

642492:CLOLE RS16365
gene id: 642492:CLOLE_RS16365
uniprot id: F2JQI3
names: Similarity
messages: Belongs to the antibiotic N-acetyltransferase family.

642492:CLOLE RS09200
gene id: 642492:CLOLE_RS09200
uniprot id: F2JN82
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

642492:CLOLE RS17770
gene id: 642492:CLOLE_RS17770
uniprot id: F2JT03
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

642492:CLOLE RS16410
gene id: 642492:CLOLE_RS16410
uniprot id: F2JQJ2
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

642492:CLOLE RS08360
gene id: 642492:CLOLE_RS08360
uniprot id: F2JLH4
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

642492:CLOLE RS11755
gene id: 642492:CLOLE_RS11755
uniprot id: F2JSA6
names: Similarity
messages: Belongs to the transpeptidase family.

642492:CLOLE RS09250
gene id: 642492:CLOLE_RS09250
uniprot id: F2JN92
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

642492:CLOLE RS09105
gene id: 642492:CLOLE_RS09105
uniprot id: F2JN62
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.

642492:CLOLE RS18280
gene id: 642492:CLOLE_RS18280
uniprot id: F2JGY5
names: Similarity
messages: Belongs to the EamA transporter family.

642492:CLOLE RS15820
gene id: 642492:CLOLE_RS15820
uniprot id: F2JPC2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Requires K(+) for maximal activity.
messages: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.

642492:CLOLE RS17095
gene id: 642492:CLOLE_RS17095
uniprot id: F2JRR1
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

642492:CLOLE RS18015
gene id: 642492:CLOLE_RS18015
uniprot id: F2JT52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

642492:CLOLE RS10150
gene id: 642492:CLOLE_RS10150
uniprot id: F2JPR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

642492:CLOLE RS11395
gene id: 642492:CLOLE_RS11395
uniprot id: F2JS34
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

642492:CLOLE RS20650
gene id: 642492:CLOLE_RS20650
uniprot id: F2JM16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

642492:CLOLE RS12020
gene id: 642492:CLOLE_RS12020
uniprot id: F2JSX5
names: Similarity
messages: Belongs to the peptidase M18 family.

642492:CLOLE RS08585
gene id: 642492:CLOLE_RS08585
uniprot id: F2JLL9
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

642492:CLOLE RS10430
gene id: 642492:CLOLE_RS10430
uniprot id: F2JQC0
names: Similarity
messages: Belongs to the UPF0237 family.

642492:CLOLE RS05970
gene id: 642492:CLOLE_RS05970
uniprot id: F2JSP3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

642492:CLOLE RS09215
gene id: 642492:CLOLE_RS09215
uniprot id: F2JN85
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

642492:CLOLE RS06230
gene id: 642492:CLOLE_RS06230
uniprot id: F2JGH5
names: Function
names: Similarity
messages: Belongs to the nucleoside phosphorylase PpnP family.
messages: Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.

642492:CLOLE RS09205
gene id: 642492:CLOLE_RS09205
uniprot id: F2JN83
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

642492:CLOLE RS01890
gene id: 642492:CLOLE_RS01890
uniprot id: F2JJN9
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

642492:CLOLE RS18090
gene id: 642492:CLOLE_RS18090
uniprot id: F2JT67
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

642492:CLOLE RS14140
gene id: 642492:CLOLE_RS14140
uniprot id: F2JKZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

642492:CLOLE RS15385
gene id: 642492:CLOLE_RS15385
uniprot id: F2JNJ5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

642492:CLOLE RS12890
gene id: 642492:CLOLE_RS12890
uniprot id: F2JHM9
names: Subcellular Location Annotation
messages: Cell membrane

642492:CLOLE RS11075
gene id: 642492:CLOLE_RS11075
uniprot id: F2JRI8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

642492:CLOLE RS14260
gene id: 642492:CLOLE_RS14260
uniprot id: F2JL14
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS02465
gene id: 642492:CLOLE_RS02465
uniprot id: F2JKN3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-97 inactivates the nitrogenase reductase and regulates nitrogenase activity.

642492:CLOLE RS21285
gene id: 642492:CLOLE_RS21285
uniprot id: F2JNM8
names: Similarity
messages: Belongs to the glutamine synthetase family.

642492:CLOLE RS17760
gene id: 642492:CLOLE_RS17760
uniprot id: F2JSI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

642492:CLOLE RS19800
gene id: 642492:CLOLE_RS19800
uniprot id: F2JKB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

642492:CLOLE RS19720
gene id: 642492:CLOLE_RS19720
uniprot id: F2JK97
names: Similarity
messages: Belongs to the MotB family.

642492:CLOLE RS02410
gene id: 642492:CLOLE_RS02410
uniprot id: F2JKM2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

642492:CLOLE RS09005
gene id: 642492:CLOLE_RS09005
uniprot id: F2JMH8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

642492:CLOLE RS16945
gene id: 642492:CLOLE_RS16945
uniprot id: F2JR85
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

642492:CLOLE RS12465
gene id: 642492:CLOLE_RS12465
uniprot id: F2JGU3
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

642492:CLOLE RS01830
gene id: 642492:CLOLE_RS01830
uniprot id: F2JJM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

642492:CLOLE RS11625
gene id: 642492:CLOLE_RS11625
uniprot id: F2JS80
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

642492:CLOLE RS09975
gene id: 642492:CLOLE_RS09975
uniprot id: F2JPM9
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS10505
gene id: 642492:CLOLE_RS10505
uniprot id: F2JQD5
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

642492:CLOLE RS14475
gene id: 642492:CLOLE_RS14475
uniprot id: F2JLS1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

642492:CLOLE RS10225
gene id: 642492:CLOLE_RS10225
uniprot id: F2JPT1
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

642492:CLOLE RS04430
gene id: 642492:CLOLE_RS04430
uniprot id: F2JQ35
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

642492:CLOLE RS10530
gene id: 642492:CLOLE_RS10530
uniprot id: F2JQE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

642492:CLOLE RS15990
gene id: 642492:CLOLE_RS15990
uniprot id: F2JPV9
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

642492:CLOLE RS17295
gene id: 642492:CLOLE_RS17295
uniprot id: F2JRU9
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS18480
gene id: 642492:CLOLE_RS18480
uniprot id: F2JH28
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS14675
gene id: 642492:CLOLE_RS14675
uniprot id: F2JLW4
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

642492:CLOLE RS19195
gene id: 642492:CLOLE_RS19195
uniprot id: F2JIN9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

642492:CLOLE RS21015
gene id: 642492:CLOLE_RS21015
uniprot id: F2JMV0
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

642492:CLOLE RS19270
gene id: 642492:CLOLE_RS19270
uniprot id: F2JJC9
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

642492:CLOLE RS08495
gene id: 642492:CLOLE_RS08495
uniprot id: F2JLK1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS07150
gene id: 642492:CLOLE_RS07150
uniprot id: F2JI89
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

642492:CLOLE RS19275
gene id: 642492:CLOLE_RS19275
uniprot id: F2JJD0
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS07135
gene id: 642492:CLOLE_RS07135
uniprot id: F2JI86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

642492:CLOLE RS20960
gene id: 642492:CLOLE_RS20960
uniprot id: F2JMU0
names: Cofactor
names: Similarity
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.

642492:CLOLE RS09705
gene id: 642492:CLOLE_RS09705
uniprot id: F2JP27
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

642492:CLOLE RS11660
gene id: 642492:CLOLE_RS11660
uniprot id: F2JS87
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

642492:CLOLE RS13015
gene id: 642492:CLOLE_RS13015
uniprot id: F2JIC7
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS16635
gene id: 642492:CLOLE_RS16635
uniprot id: F2JR40
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS14390
gene id: 642492:CLOLE_RS14390
uniprot id: F2JLQ5
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS18930
gene id: 642492:CLOLE_RS18930
uniprot id: F2JII6
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS14395
gene id: 642492:CLOLE_RS14395
uniprot id: F2JLQ6
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

642492:CLOLE RS11545
gene id: 642492:CLOLE_RS11545
uniprot id: F2JS64
names: Similarity
messages: Belongs to the UPF0102 family.

642492:CLOLE RS17305
gene id: 642492:CLOLE_RS17305
uniprot id: F2JRV1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

642492:CLOLE RS02830
gene id: 642492:CLOLE_RS02830
uniprot id: F2JLG8
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

642492:CLOLE RS04050
gene id: 642492:CLOLE_RS04050
uniprot id: F2JPE9
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

642492:CLOLE RS16625
gene id: 642492:CLOLE_RS16625
uniprot id: F2JR38
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

642492:CLOLE RS17820
gene id: 642492:CLOLE_RS17820
uniprot id: F2JT13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

642492:CLOLE RS17725
gene id: 642492:CLOLE_RS17725
uniprot id: F2JSH5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

642492:CLOLE RS17200
gene id: 642492:CLOLE_RS17200
uniprot id: F2JRT2
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

642492:CLOLE RS20955
gene id: 642492:CLOLE_RS20955
uniprot id: F2JMT9
names: Similarity
messages: Belongs to the EamA transporter family.

642492:CLOLE RS13710
gene id: 642492:CLOLE_RS13710
uniprot id: F2JK19
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS17680
gene id: 642492:CLOLE_RS17680
uniprot id: F2JSG6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

642492:CLOLE RS18570
gene id: 642492:CLOLE_RS18570
uniprot id: F2JHP4
names: Similarity
messages: Belongs to the asparagine synthetase family.

642492:CLOLE RS21400
gene id: 642492:CLOLE_RS21400
uniprot id: F2JNQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

642492:CLOLE RS13380
gene id: 642492:CLOLE_RS13380
uniprot id: F2JJ75
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

642492:CLOLE RS21720
gene id: 642492:CLOLE_RS21720
uniprot id: F2JGM4
names: Similarity
messages: Belongs to the transposase 11 family.

642492:CLOLE RS08925
gene id: 642492:CLOLE_RS08925
uniprot id: F2JMG0
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

642492:CLOLE RS07920
gene id: 642492:CLOLE_RS07920
uniprot id: F2JJZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

642492:CLOLE RS02815
gene id: 642492:CLOLE_RS02815
uniprot id: F2JLG5
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS12475
gene id: 642492:CLOLE_RS12475
uniprot id: F2JGU5
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

642492:CLOLE RS13450
gene id: 642492:CLOLE_RS13450
uniprot id: F2JJ89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

642492:CLOLE RS11560
gene id: 642492:CLOLE_RS11560
uniprot id: F2JS67
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

642492:CLOLE RS00610
gene id: 642492:CLOLE_RS00610
uniprot id: F2JH42
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

642492:CLOLE RS12325
gene id: 642492:CLOLE_RS12325
uniprot id: F2JGR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

642492:CLOLE RS00730
gene id: 642492:CLOLE_RS00730
uniprot id: F2JH53
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

642492:CLOLE RS03685
gene id: 642492:CLOLE_RS03685
uniprot id: F2JNS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 1 family.
messages: Secreted

642492:CLOLE RS09605
gene id: 642492:CLOLE_RS09605
uniprot id: F2JP07
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS10405
gene id: 642492:CLOLE_RS10405
uniprot id: F2JQB5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

642492:CLOLE RS11615
gene id: 642492:CLOLE_RS11615
uniprot id: F2JS78
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

642492:CLOLE RS14285
gene id: 642492:CLOLE_RS14285
uniprot id: F2JL19
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

642492:CLOLE RS10065
gene id: 642492:CLOLE_RS10065
uniprot id: F2JPP6
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

642492:CLOLE RS15245
gene id: 642492:CLOLE_RS15245
uniprot id: F2JNG7
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

642492:CLOLE RS10625
gene id: 642492:CLOLE_RS10625
uniprot id: F2JQW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

642492:CLOLE RS14820
gene id: 642492:CLOLE_RS14820
uniprot id: F2JML7
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

642492:CLOLE RS15740
gene id: 642492:CLOLE_RS15740
uniprot id: F2JPA6
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

642492:CLOLE RS05590
gene id: 642492:CLOLE_RS05590
uniprot id: F2JRZ8
names: Similarity
messages: Belongs to the MecA family.

642492:CLOLE RS14650
gene id: 642492:CLOLE_RS14650
uniprot id: F2JLV9
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS19900
gene id: 642492:CLOLE_RS19900
uniprot id: F2JKD1
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS12320
gene id: 642492:CLOLE_RS12320
uniprot id: F2JGR3
names: Similarity
messages: Belongs to the MotB family.

642492:CLOLE RS06770
gene id: 642492:CLOLE_RS06770
uniprot id: F2JHE4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS12470
gene id: 642492:CLOLE_RS12470
uniprot id: F2JGU4
names: Similarity
messages: Belongs to the asparaginase 1 family.

642492:CLOLE RS02380
gene id: 642492:CLOLE_RS02380
uniprot id: F2JKL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein SsuA/TauA family.
messages: Periplasm

642492:CLOLE RS12730
gene id: 642492:CLOLE_RS12730
uniprot id: F2JHJ9
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

642492:CLOLE RS12290
gene id: 642492:CLOLE_RS12290
uniprot id: F2JGQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

642492:CLOLE RS03765
gene id: 642492:CLOLE_RS03765
uniprot id: F2JNT9
names: Similarity
messages: Belongs to the TrpC family.

642492:CLOLE RS05985
gene id: 642492:CLOLE_RS05985
uniprot id: F2JSP6
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

642492:CLOLE RS07355
gene id: 642492:CLOLE_RS07355
uniprot id: F2JIZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
messages: Homohexamer; trimer of homodimers.

642492:CLOLE RS09925
gene id: 642492:CLOLE_RS09925
uniprot id: F2JPM0
names: Similarity
messages: Belongs to the peptidase S33 family.

642492:CLOLE RS05470
gene id: 642492:CLOLE_RS05470
uniprot id: F2JRY3
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

642492:CLOLE RS04690
gene id: 642492:CLOLE_RS04690
uniprot id: F2JQP0
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

642492:CLOLE RS21865
gene id: 642492:CLOLE_RS21865
uniprot id: F2JRK0
names: Subcellular Location Annotation
messages: Secreted

642492:CLOLE RS01590
gene id: 642492:CLOLE_RS01590
uniprot id: F2JIV2
names: Similarity
messages: Belongs to the Dps family.

642492:CLOLE RS11610
gene id: 642492:CLOLE_RS11610
uniprot id: F2JS77
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

642492:CLOLE RS13065
gene id: 642492:CLOLE_RS13065
uniprot id: F2JID7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

642492:CLOLE RS05655
gene id: 642492:CLOLE_RS05655
uniprot id: F2JS12
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

642492:CLOLE RS09160
gene id: 642492:CLOLE_RS09160
uniprot id: F2JN73
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

642492:CLOLE RS03775
gene id: 642492:CLOLE_RS03775
uniprot id: F2JNU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

642492:CLOLE RS11630
gene id: 642492:CLOLE_RS11630
uniprot id: F2JS81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

642492:CLOLE RS01290
gene id: 642492:CLOLE_RS01290
uniprot id: F2JI21
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. Sucrose phosphorylase subfamily.

642492:CLOLE RS07385
gene id: 642492:CLOLE_RS07385
uniprot id: F2JJ05
names: Similarity
messages: Belongs to the AAA ATPase family.

642492:CLOLE RS12145
gene id: 642492:CLOLE_RS12145
uniprot id: F2JSZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

642492:CLOLE RS02950
gene id: 642492:CLOLE_RS02950
uniprot id: F2JM68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS11210
gene id: 642492:CLOLE_RS11210
uniprot id: F2JRL3
names: Function
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Catalyzes the one-electron reduction of superoxide anion radical to hydrogen peroxide at a nonheme ferrous iron center. Plays a fundamental role in case of oxidative stress via its superoxide detoxification activity.

642492:CLOLE RS08540
gene id: 642492:CLOLE_RS08540
uniprot id: F2JLL0
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS02180
gene id: 642492:CLOLE_RS02180
uniprot id: F2JKH7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

642492:CLOLE RS03400
gene id: 642492:CLOLE_RS03400
uniprot id: F2JN22
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

642492:CLOLE RS01195
gene id: 642492:CLOLE_RS01195
uniprot id: F2JI04
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS03115
gene id: 642492:CLOLE_RS03115
uniprot id: F2JM99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS11005
gene id: 642492:CLOLE_RS11005
uniprot id: F2JRH4
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

642492:CLOLE RS05235
gene id: 642492:CLOLE_RS05235
uniprot id: F2JRE2
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

642492:CLOLE RS09830
gene id: 642492:CLOLE_RS09830
uniprot id: F2JP51
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

642492:CLOLE RS06370
gene id: 642492:CLOLE_RS06370
uniprot id: F2JGK4
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS01480
gene id: 642492:CLOLE_RS01480
uniprot id: F2JIT1
names: Similarity
messages: Belongs to the hemerythrin family.

642492:CLOLE RS02715
gene id: 642492:CLOLE_RS02715
uniprot id: F2JLE6
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS10775
gene id: 642492:CLOLE_RS10775
uniprot id: F2JQZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

642492:CLOLE RS04425
gene id: 642492:CLOLE_RS04425
uniprot id: F2JQ34
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS13560
gene id: 642492:CLOLE_RS13560
uniprot id: F2JJB1
names: Cofactor
messages: Binds 1 zinc ion per subunit.

642492:CLOLE RS19185
gene id: 642492:CLOLE_RS19185
uniprot id: F2JIN7
names: Similarity
messages: Belongs to the UDPGP type 2 family.

642492:CLOLE RS05370
gene id: 642492:CLOLE_RS05370
uniprot id: F2JRH0
names: Similarity
messages: Belongs to the asparagine synthetase family.

642492:CLOLE RS12390
gene id: 642492:CLOLE_RS12390
uniprot id: F2JGS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

642492:CLOLE RS17145
gene id: 642492:CLOLE_RS17145
uniprot id: F2JRS1
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

642492:CLOLE RS18245
gene id: 642492:CLOLE_RS18245
uniprot id: F2JGX8
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

642492:CLOLE RS02625
gene id: 642492:CLOLE_RS02625
uniprot id: F2JLD0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

642492:CLOLE RS01055
gene id: 642492:CLOLE_RS01055
uniprot id: F2JHX9
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

642492:CLOLE RS09760
gene id: 642492:CLOLE_RS09760
uniprot id: F2JP37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Cell membrane

642492:CLOLE RS05170
gene id: 642492:CLOLE_RS05170
uniprot id: F2JRC9
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

642492:CLOLE RS05660
gene id: 642492:CLOLE_RS05660
uniprot id: F2JS13
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

642492:CLOLE RS16950
gene id: 642492:CLOLE_RS16950
uniprot id: F2JR86
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS11115
gene id: 642492:CLOLE_RS11115
uniprot id: F2JRJ6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

642492:CLOLE RS16800
gene id: 642492:CLOLE_RS16800
uniprot id: F2JR56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

642492:CLOLE RS08290
gene id: 642492:CLOLE_RS08290
uniprot id: F2JKU8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS20975
gene id: 642492:CLOLE_RS20975
uniprot id: F2JMU3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

642492:CLOLE RS06365
gene id: 642492:CLOLE_RS06365
uniprot id: F2JGK3
names: Similarity
messages: Belongs to the CAPAB/TerDEXZ family.

642492:CLOLE RS17670
gene id: 642492:CLOLE_RS17670
uniprot id: F2JSG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

642492:CLOLE RS06425
gene id: 642492:CLOLE_RS06425
uniprot id: F2JGL5
names: Similarity
messages: Belongs to the peptidase S8 family.

642492:CLOLE RS10265
gene id: 642492:CLOLE_RS10265
uniprot id: F2JQ86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

642492:CLOLE RS13670
gene id: 642492:CLOLE_RS13670
uniprot id: F2JK10
names: Similarity
messages: Belongs to the peptidase S8 family.

642492:CLOLE RS10495
gene id: 642492:CLOLE_RS10495
uniprot id: F2JQD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

642492:CLOLE RS12185
gene id: 642492:CLOLE_RS12185
uniprot id: F2JGN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

642492:CLOLE RS17675
gene id: 642492:CLOLE_RS17675
uniprot id: F2JSG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

642492:CLOLE RS10115
gene id: 642492:CLOLE_RS10115
uniprot id: F2JPQ5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

642492:CLOLE RS16970
gene id: 642492:CLOLE_RS16970
uniprot id: F2JR90
names: Caution
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
messages: Belongs to the biotin--protein ligase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS15655
gene id: 642492:CLOLE_RS15655
uniprot id: F2JP88
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

642492:CLOLE RS09655
gene id: 642492:CLOLE_RS09655
uniprot id: F2JP17
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

642492:CLOLE RS17580
gene id: 642492:CLOLE_RS17580
uniprot id: F2JSE6
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 26 family. TagA/TarA subfamily.
messages: Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid.

642492:CLOLE RS14070
gene id: 642492:CLOLE_RS14070
uniprot id: F2JKX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

642492:CLOLE RS10860
gene id: 642492:CLOLE_RS10860
uniprot id: F2JR09
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.

642492:CLOLE RS14145
gene id: 642492:CLOLE_RS14145
uniprot id: F2JKZ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

642492:CLOLE RS14590
gene id: 642492:CLOLE_RS14590
uniprot id: F2JLU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

642492:CLOLE RS16425
gene id: 642492:CLOLE_RS16425
uniprot id: F2JQJ5
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

642492:CLOLE RS15050
gene id: 642492:CLOLE_RS15050
uniprot id: F2JMQ4
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

642492:CLOLE RS10955
gene id: 642492:CLOLE_RS10955
uniprot id: F2JR29
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

642492:CLOLE RS06545
gene id: 642492:CLOLE_RS06545
uniprot id: F2JH96
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

642492:CLOLE RS17655
gene id: 642492:CLOLE_RS17655
uniprot id: F2JSG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS10895
gene id: 642492:CLOLE_RS10895
uniprot id: F2JR16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

642492:CLOLE RS11710
gene id: 642492:CLOLE_RS11710
uniprot id: F2JS97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U4 family.
messages: Cell membrane
messages: Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR.

642492:CLOLE RS05715
gene id: 642492:CLOLE_RS05715
uniprot id: F2JS24
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

642492:CLOLE RS16610
gene id: 642492:CLOLE_RS16610
uniprot id: F2JQN2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

642492:CLOLE RS17860
gene id: 642492:CLOLE_RS17860
uniprot id: F2JT21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

642492:CLOLE RS00565
gene id: 642492:CLOLE_RS00565
uniprot id: F2JGF1
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS08120
gene id: 642492:CLOLE_RS08120
uniprot id: F2JKR4
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.

642492:CLOLE RS11310
gene id: 642492:CLOLE_RS11310
uniprot id: F2JRN2
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

642492:CLOLE RS17160
gene id: 642492:CLOLE_RS17160
uniprot id: F2JRS4
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

642492:CLOLE RS14730
gene id: 642492:CLOLE_RS14730
uniprot id: F2JMJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0053 family.
messages: Membrane

642492:CLOLE RS18585
gene id: 642492:CLOLE_RS18585
uniprot id: F2JHP7
names: Similarity
messages: Belongs to the glycosyl hydrolase 42 family.

642492:CLOLE RS18185
gene id: 642492:CLOLE_RS18185
uniprot id: F2JGW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

642492:CLOLE RS05855
gene id: 642492:CLOLE_RS05855
uniprot id: F2JSM2
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

642492:CLOLE RS20185
gene id: 642492:CLOLE_RS20185
uniprot id: F2JL60
names: Similarity
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.

642492:CLOLE RS16895
gene id: 642492:CLOLE_RS16895
uniprot id: F2JR75
names: Similarity
messages: Belongs to the glycosyl hydrolase.

642492:CLOLE RS16080
gene id: 642492:CLOLE_RS16080
uniprot id: F2JPX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS06335
gene id: 642492:CLOLE_RS06335
uniprot id: F2JGJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS18180
gene id: 642492:CLOLE_RS18180
uniprot id: F2JGW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

642492:CLOLE RS23875
gene id: 642492:CLOLE_RS23875
uniprot id: F2JLY5
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

642492:CLOLE RS05560
gene id: 642492:CLOLE_RS05560
uniprot id: F2JRZ2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

642492:CLOLE RS18840
gene id: 642492:CLOLE_RS18840
uniprot id: F2JHS8
names: Similarity
messages: Belongs to the WXG100 family.

642492:CLOLE RS13350
gene id: 642492:CLOLE_RS13350
uniprot id: F2JJ69
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

642492:CLOLE RS11530
gene id: 642492:CLOLE_RS11530
uniprot id: F2JS61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

642492:CLOLE RS07155
gene id: 642492:CLOLE_RS07155
uniprot id: F2JI90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

642492:CLOLE RS21350
gene id: 642492:CLOLE_RS21350
uniprot id: F2JNP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

642492:CLOLE RS18340
gene id: 642492:CLOLE_RS18340
uniprot id: F2JGZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
messages: Homooctamer.

642492:CLOLE RS14210
gene id: 642492:CLOLE_RS14210
uniprot id: F2JL05
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

642492:CLOLE RS02785
gene id: 642492:CLOLE_RS02785
uniprot id: F2JLF9
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS20880
gene id: 642492:CLOLE_RS20880
uniprot id: F2JMS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS16150
gene id: 642492:CLOLE_RS16150
uniprot id: F2JPZ1
names: Similarity
messages: Belongs to the EamA transporter family.

642492:CLOLE RS11340
gene id: 642492:CLOLE_RS11340
uniprot id: F2JRN8
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS14665
gene id: 642492:CLOLE_RS14665
uniprot id: F2JLW2
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

642492:CLOLE RS04810
gene id: 642492:CLOLE_RS04810
uniprot id: F2JQR2
names: Similarity
messages: Belongs to the CvfB family.

642492:CLOLE RS11635
gene id: 642492:CLOLE_RS11635
uniprot id: F2JS82
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

642492:CLOLE RS09625
gene id: 642492:CLOLE_RS09625
uniprot id: F2JP11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

642492:CLOLE RS10950
gene id: 642492:CLOLE_RS10950
uniprot id: F2JR28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

642492:CLOLE RS11760
gene id: 642492:CLOLE_RS11760
uniprot id: F2JSA7
names: Similarity
messages: Belongs to the transpeptidase family.

642492:CLOLE RS13355
gene id: 642492:CLOLE_RS13355
uniprot id: F2JJ70
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

642492:CLOLE RS07045
gene id: 642492:CLOLE_RS07045
uniprot id: F2JI67
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

642492:CLOLE RS03035
gene id: 642492:CLOLE_RS03035
uniprot id: F2JM83
names: Similarity
messages: Belongs to the glycosyl hydrolase 67 family.

642492:CLOLE RS19775
gene id: 642492:CLOLE_RS19775
uniprot id: F2JKA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

642492:CLOLE RS13315
gene id: 642492:CLOLE_RS13315
uniprot id: F2JJ61
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS04770
gene id: 642492:CLOLE_RS04770
uniprot id: F2JQQ4
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS19285
gene id: 642492:CLOLE_RS19285
uniprot id: F2JJD2
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS18295
gene id: 642492:CLOLE_RS18295
uniprot id: F2JGY8
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS03085
gene id: 642492:CLOLE_RS03085
uniprot id: F2JM93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

642492:CLOLE RS19040
gene id: 642492:CLOLE_RS19040
uniprot id: F2JIK8
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

642492:CLOLE RS08875
gene id: 642492:CLOLE_RS08875
uniprot id: F2JMF0
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

642492:CLOLE RS03550
gene id: 642492:CLOLE_RS03550
uniprot id: F2JN52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

642492:CLOLE RS05380
gene id: 642492:CLOLE_RS05380
uniprot id: F2JRH2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS03010
gene id: 642492:CLOLE_RS03010
uniprot id: F2JM78
names: Similarity
messages: Belongs to the TelA family.

642492:CLOLE RS08825
gene id: 642492:CLOLE_RS08825
uniprot id: F2JME0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

642492:CLOLE RS15730
gene id: 642492:CLOLE_RS15730
uniprot id: F2JPA4
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

642492:CLOLE RS08545
gene id: 642492:CLOLE_RS08545
uniprot id: F2JLL1
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

642492:CLOLE RS03330
gene id: 642492:CLOLE_RS03330
uniprot id: F2JN08
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS11345
gene id: 642492:CLOLE_RS11345
uniprot id: F2JRN9
names: Similarity
messages: Belongs to the pyruvate kinase family.
messages: In the C-terminal section; belongs to the PEP-utilizing enzyme family.

642492:CLOLE RS14645
gene id: 642492:CLOLE_RS14645
uniprot id: F2JLV8
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

642492:CLOLE RS05580
gene id: 642492:CLOLE_RS05580
uniprot id: F2JRZ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

642492:CLOLE RS10550
gene id: 642492:CLOLE_RS10550
uniprot id: F2JQE4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

642492:CLOLE RS09740
gene id: 642492:CLOLE_RS09740
uniprot id: F2JP33
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

642492:CLOLE RS12830
gene id: 642492:CLOLE_RS12830
uniprot id: F2JHM0
names: Similarity
messages: Belongs to the BMP lipoprotein family.

642492:CLOLE RS14720
gene id: 642492:CLOLE_RS14720
uniprot id: F2JLX2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

642492:CLOLE RS14875
gene id: 642492:CLOLE_RS14875
uniprot id: F2JMM8
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS01280
gene id: 642492:CLOLE_RS01280
uniprot id: F2JI19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS03300
gene id: 642492:CLOLE_RS03300
uniprot id: F2JN02
names: Subcellular Location Annotation
messages: Cytoplasm

642492:CLOLE RS00010
gene id: 642492:CLOLE_RS00010
uniprot id: F2JSI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

642492:CLOLE RS12480
gene id: 642492:CLOLE_RS12480
uniprot id: F2JGU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

642492:CLOLE RS16045
gene id: 642492:CLOLE_RS16045
uniprot id: F2JPX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

642492:CLOLE RS15130
gene id: 642492:CLOLE_RS15130
uniprot id: F2JNE5
names: Function
names: Similarity
messages: Belongs to the RecD family. RecD-like subfamily.
messages: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.

642492:CLOLE RS02875
gene id: 642492:CLOLE_RS02875
uniprot id: F2JM53
names: Similarity
messages: Belongs to the glycosyl hydrolase 8 (cellulase D) family.

642492:CLOLE RS00185
gene id: 642492:CLOLE_RS00185
uniprot id: F2JSK7
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

642492:CLOLE RS14250
gene id: 642492:CLOLE_RS14250
uniprot id: F2JL12
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

642492:CLOLE RS23715
gene id: 642492:CLOLE_RS23715
uniprot id: F2JKB0
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

642492:CLOLE RS10325
gene id: 642492:CLOLE_RS10325
uniprot id: F2JQ98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

642492:CLOLE RS08105
gene id: 642492:CLOLE_RS08105
uniprot id: F2JKR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS06340
gene id: 642492:CLOLE_RS06340
uniprot id: F2JGJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS02855
gene id: 642492:CLOLE_RS02855
uniprot id: F2JM49
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS16955
gene id: 642492:CLOLE_RS16955
uniprot id: F2JR87
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS13540
gene id: 642492:CLOLE_RS13540
uniprot id: F2JJA7
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

642492:CLOLE RS01920
gene id: 642492:CLOLE_RS01920
uniprot id: F2JJP5
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS09785
gene id: 642492:CLOLE_RS09785
uniprot id: F2JP42
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS10490
gene id: 642492:CLOLE_RS10490
uniprot id: F2JQD2
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

642492:CLOLE RS15060
gene id: 642492:CLOLE_RS15060
uniprot id: F2JMQ6
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.

642492:CLOLE RS14265
gene id: 642492:CLOLE_RS14265
uniprot id: F2JL15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

642492:CLOLE RS08420
gene id: 642492:CLOLE_RS08420
uniprot id: F2JLI5
names: Similarity
messages: Belongs to the peptidase C40 family.

642492:CLOLE RS18450
gene id: 642492:CLOLE_RS18450
uniprot id: F2JH22
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

642492:CLOLE RS11455
gene id: 642492:CLOLE_RS11455
uniprot id: F2JS46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ScpA family.
messages: Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.
messages: Cytoplasm
messages: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.

642492:CLOLE RS00995
gene id: 642492:CLOLE_RS00995
uniprot id: F2JHW7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

642492:CLOLE RS03660
gene id: 642492:CLOLE_RS03660
uniprot id: F2JNR8
names: Similarity
messages: Belongs to the glycosyl hydrolase 9 (cellulase E) family.

642492:CLOLE RS12990
gene id: 642492:CLOLE_RS12990
uniprot id: F2JIC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-C family. DnaE subfamily.
messages: Cytoplasm
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase.

642492:CLOLE RS04575
gene id: 642492:CLOLE_RS04575
uniprot id: F2JQ65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS13360
gene id: 642492:CLOLE_RS13360
uniprot id: F2JJ71
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS16640
gene id: 642492:CLOLE_RS16640
uniprot id: F2JR41
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

642492:CLOLE RS07755
gene id: 642492:CLOLE_RS07755
uniprot id: F2JJW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched chain amino acid transporter family.
messages: Cell membrane
messages: Component of the transport system for branched-chain amino acids.
messages: Membrane

642492:CLOLE RS11090
gene id: 642492:CLOLE_RS11090
uniprot id: F2JRJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

642492:CLOLE RS15350
gene id: 642492:CLOLE_RS15350
uniprot id: F2JNI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Membrane

642492:CLOLE RS13280
gene id: 642492:CLOLE_RS13280
uniprot id: F2JJ54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS05675
gene id: 642492:CLOLE_RS05675
uniprot id: F2JS16
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS06555
gene id: 642492:CLOLE_RS06555
uniprot id: F2JH98
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS20700
gene id: 642492:CLOLE_RS20700
uniprot id: F2JM24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

642492:CLOLE RS14925
gene id: 642492:CLOLE_RS14925
uniprot id: F2JMN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

642492:CLOLE RS12050
gene id: 642492:CLOLE_RS12050
uniprot id: F2JSY1
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

642492:CLOLE RS17730
gene id: 642492:CLOLE_RS17730
uniprot id: F2JSH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

642492:CLOLE RS12605
gene id: 642492:CLOLE_RS12605
uniprot id: F2JHH4
names: Similarity
messages: Belongs to the UbiD family.

642492:CLOLE RS08485
gene id: 642492:CLOLE_RS08485
uniprot id: F2JLJ8
names: Similarity
messages: Belongs to the heat shock protein 90 family.

642492:CLOLE RS12285
gene id: 642492:CLOLE_RS12285
uniprot id: F2JGQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

642492:CLOLE RS19935
gene id: 642492:CLOLE_RS19935
uniprot id: F2JKD9
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

642492:CLOLE RS12505
gene id: 642492:CLOLE_RS12505
uniprot id: F2JGV2
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

642492:CLOLE RS11540
gene id: 642492:CLOLE_RS11540
uniprot id: F2JS63
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

642492:CLOLE RS18575
gene id: 642492:CLOLE_RS18575
uniprot id: F2JHP5
names: Similarity
messages: Belongs to the helicase family. RAD3/XPD subfamily.

642492:CLOLE RS21700
gene id: 642492:CLOLE_RS21700
uniprot id: F2JSN8
names: Similarity
messages: Belongs to the transposase 11 family.

642492:CLOLE RS11205
gene id: 642492:CLOLE_RS11205
uniprot id: F2JRL2
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

642492:CLOLE RS22005
gene id: 642492:CLOLE_RS22005
uniprot id: F2JGM4
names: Similarity
messages: Belongs to the transposase 11 family.

642492:CLOLE RS08370
gene id: 642492:CLOLE_RS08370
uniprot id: F2JLH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

642492:CLOLE RS17785
gene id: 642492:CLOLE_RS17785
uniprot id: F2JT06
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

642492:CLOLE RS08195
gene id: 642492:CLOLE_RS08195
uniprot id: F2JKS9
names: Similarity
messages: Belongs to the BMP lipoprotein family.

642492:CLOLE RS11750
gene id: 642492:CLOLE_RS11750
uniprot id: F2JSA5
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS08995
gene id: 642492:CLOLE_RS08995
uniprot id: F2JMH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

642492:CLOLE RS02915
gene id: 642492:CLOLE_RS02915
uniprot id: F2JM61
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

642492:CLOLE RS10575
gene id: 642492:CLOLE_RS10575
uniprot id: F2JQE9
names: Similarity
messages: Belongs to the transpeptidase family.

642492:CLOLE RS05935
gene id: 642492:CLOLE_RS05935
uniprot id: F2JSN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

642492:CLOLE RS04115
gene id: 642492:CLOLE_RS04115
uniprot id: F2JPG2
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

642492:CLOLE RS13465
gene id: 642492:CLOLE_RS13465
uniprot id: F2JJ92
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

642492:CLOLE RS12210
gene id: 642492:CLOLE_RS12210
uniprot id: F2JGP1
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

642492:CLOLE RS09935
gene id: 642492:CLOLE_RS09935
uniprot id: F2JPM2
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS11040
gene id: 642492:CLOLE_RS11040
uniprot id: F2JRI1
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

642492:CLOLE RS08135
gene id: 642492:CLOLE_RS08135
uniprot id: F2JKR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArsB family.
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS18240
gene id: 642492:CLOLE_RS18240
uniprot id: F2JGX7
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

642492:CLOLE RS03395
gene id: 642492:CLOLE_RS03395
uniprot id: F2JN21
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS09775
gene id: 642492:CLOLE_RS09775
uniprot id: F2JP40
names: Caution
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

642492:CLOLE RS01015
gene id: 642492:CLOLE_RS01015
uniprot id: F2JHX1
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

642492:CLOLE RS05665
gene id: 642492:CLOLE_RS05665
uniprot id: F2JS14
names: Similarity
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

642492:CLOLE RS10765
gene id: 642492:CLOLE_RS10765
uniprot id: F2JQZ0
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS16600
gene id: 642492:CLOLE_RS16600
uniprot id: F2JQN0
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

642492:CLOLE RS15070
gene id: 642492:CLOLE_RS15070
uniprot id: F2JMQ8
names: Similarity
messages: Belongs to the ClpA/ClpB family.

642492:CLOLE RS13550
gene id: 642492:CLOLE_RS13550
uniprot id: F2JJA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

642492:CLOLE RS00275
gene id: 642492:CLOLE_RS00275
uniprot id: F2JGA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 32 family.
messages: Cytoplasm
messages: Enables the bacterium to metabolize sucrose as a sole carbon source.

642492:CLOLE RS05920
gene id: 642492:CLOLE_RS05920
uniprot id: F2JSN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

642492:CLOLE RS11510
gene id: 642492:CLOLE_RS11510
uniprot id: F2JS57
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

642492:CLOLE RS13615
gene id: 642492:CLOLE_RS13615
uniprot id: F2JJC1
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

642492:CLOLE RS02975
gene id: 642492:CLOLE_RS02975
uniprot id: F2JM72
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20 family.
messages: Binds 2 Zn(2+) ions per subunit.

642492:CLOLE RS14455
gene id: 642492:CLOLE_RS14455
uniprot id: F2JLR7
names: Similarity
messages: Belongs to the peptidase M56 family.

642492:CLOLE RS10755
gene id: 642492:CLOLE_RS10755
uniprot id: F2JQY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

642492:CLOLE RS15660
gene id: 642492:CLOLE_RS15660
uniprot id: F2JP89
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

642492:CLOLE RS11475
gene id: 642492:CLOLE_RS11475
uniprot id: F2JS50
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

642492:CLOLE RS08405
gene id: 642492:CLOLE_RS08405
uniprot id: F2JLI2
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

642492:CLOLE RS03345
gene id: 642492:CLOLE_RS03345
uniprot id: F2JN11
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS09195
gene id: 642492:CLOLE_RS09195
uniprot id: F2JN81
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS06760
gene id: 642492:CLOLE_RS06760
uniprot id: F2JHE2
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS15430
gene id: 642492:CLOLE_RS15430
uniprot id: F2JNK5
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS15725
gene id: 642492:CLOLE_RS15725
uniprot id: F2JPA3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

642492:CLOLE RS03800
gene id: 642492:CLOLE_RS03800
uniprot id: F2JNU6
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS07805
gene id: 642492:CLOLE_RS07805
uniprot id: F2JJX2
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

642492:CLOLE RS08400
gene id: 642492:CLOLE_RS08400
uniprot id: F2JLI1
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
messages: Homohexamer.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

642492:CLOLE RS19210
gene id: 642492:CLOLE_RS19210
uniprot id: F2JIP2
names: Similarity
messages: Belongs to the GerABKC lipoprotein family.

642492:CLOLE RS11645
gene id: 642492:CLOLE_RS11645
uniprot id: F2JS84
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

642492:CLOLE RS12060
gene id: 642492:CLOLE_RS12060
uniprot id: F2JSY3
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

642492:CLOLE RS00605
gene id: 642492:CLOLE_RS00605
uniprot id: F2JH41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0397 family.
messages: Cell membrane

642492:CLOLE RS00545
gene id: 642492:CLOLE_RS00545
uniprot id: F2JGE4
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS21895
gene id: 642492:CLOLE_RS21895
uniprot id: F2JGS5
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

642492:CLOLE RS07875
gene id: 642492:CLOLE_RS07875
uniprot id: F2JJY6
names: Similarity
messages: Belongs to the NAPRTase family.

642492:CLOLE RS15115
gene id: 642492:CLOLE_RS15115
uniprot id: F2JNE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

642492:CLOLE RS11840
gene id: 642492:CLOLE_RS11840
uniprot id: F2JSU1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

642492:CLOLE RS12190
gene id: 642492:CLOLE_RS12190
uniprot id: F2JGN7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

642492:CLOLE RS14180
gene id: 642492:CLOLE_RS14180
uniprot id: F2JKZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

642492:CLOLE RS03705
gene id: 642492:CLOLE_RS03705
uniprot id: F2JNS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS02750
gene id: 642492:CLOLE_RS02750
uniprot id: F2JLF2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the arabinose isomerase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of L-arabinose to L-ribulose.

642492:CLOLE RS12485
gene id: 642492:CLOLE_RS12485
uniprot id: F2JGU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

642492:CLOLE RS17700
gene id: 642492:CLOLE_RS17700
uniprot id: F2JSH0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

642492:CLOLE RS19375
gene id: 642492:CLOLE_RS19375
uniprot id: F2JJF0
names: Cofactor
names: Similarity
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.

642492:CLOLE RS20555
gene id: 642492:CLOLE_RS20555
uniprot id: F2JLZ9
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS20625
gene id: 642492:CLOLE_RS20625
uniprot id: F2JM13
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS06015
gene id: 642492:CLOLE_RS06015
uniprot id: F2JSQ3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

642492:CLOLE RS15260
gene id: 642492:CLOLE_RS15260
uniprot id: F2JNH0
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

642492:CLOLE RS01295
gene id: 642492:CLOLE_RS01295
uniprot id: F2JI22
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

642492:CLOLE RS04665
gene id: 642492:CLOLE_RS04665
uniprot id: F2JQN5
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

642492:CLOLE RS17490
gene id: 642492:CLOLE_RS17490
uniprot id: F2JSC8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

642492:CLOLE RS12340
gene id: 642492:CLOLE_RS12340
uniprot id: F2JGR7
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

642492:CLOLE RS19215
gene id: 642492:CLOLE_RS19215
uniprot id: F2JIP3
names: Similarity
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.

642492:CLOLE RS05555
gene id: 642492:CLOLE_RS05555
uniprot id: F2JRZ1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GdpP/PdeA phosphodiesterase family.
messages: Cell membrane
messages: For phosphodiesterase activity, probably binds 2 Mn(2+) per subunit.
messages: Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP).

642492:CLOLE RS08655
gene id: 642492:CLOLE_RS08655
uniprot id: F2JLN3
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS19355
gene id: 642492:CLOLE_RS19355
uniprot id: F2JJE6
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS20670
gene id: 642492:CLOLE_RS20670
uniprot id: F2JM18
names: Subcellular Location Annotation
messages: Cell membrane

642492:CLOLE RS18560
gene id: 642492:CLOLE_RS18560
uniprot id: F2JHP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS01495
gene id: 642492:CLOLE_RS01495
uniprot id: F2JIT4
names: Similarity
messages: Belongs to the CdaR family.

642492:CLOLE RS10825
gene id: 642492:CLOLE_RS10825
uniprot id: F2JR02
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Catalyzes the methylation of 5-hydroxyuridine (ho5U) to form 5-methoxyuridine (mo5U) at position 34 in tRNAs.
messages: Homodimer.

642492:CLOLE RS08870
gene id: 642492:CLOLE_RS08870
uniprot id: F2JME9
names: Similarity
messages: Belongs to the asp23 family.

642492:CLOLE RS12300
gene id: 642492:CLOLE_RS12300
uniprot id: F2JGQ9
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS18495
gene id: 642492:CLOLE_RS18495
uniprot id: F2JH31
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

642492:CLOLE RS20125
gene id: 642492:CLOLE_RS20125
uniprot id: F2JL48
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

642492:CLOLE RS21260
gene id: 642492:CLOLE_RS21260
uniprot id: F2JNM3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

642492:CLOLE RS04560
gene id: 642492:CLOLE_RS04560
uniprot id: F2JQ62
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

642492:CLOLE RS04020
gene id: 642492:CLOLE_RS04020
uniprot id: F2JPE4
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS15080
gene id: 642492:CLOLE_RS15080
uniprot id: F2JMR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS10285
gene id: 642492:CLOLE_RS10285
uniprot id: F2JQ90
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

642492:CLOLE RS05320
gene id: 642492:CLOLE_RS05320
uniprot id: F2JRF9
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS11825
gene id: 642492:CLOLE_RS11825
uniprot id: F2JST8
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

642492:CLOLE RS05680
gene id: 642492:CLOLE_RS05680
uniprot id: F2JS17
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

642492:CLOLE RS11770
gene id: 642492:CLOLE_RS11770
uniprot id: F2JSA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

642492:CLOLE RS11655
gene id: 642492:CLOLE_RS11655
uniprot id: F2JS86
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

642492:CLOLE RS12010
gene id: 642492:CLOLE_RS12010
uniprot id: F2JSX3
names: Similarity
messages: Belongs to the UPF0473 family.

642492:CLOLE RS10220
gene id: 642492:CLOLE_RS10220
uniprot id: F2JPT0
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

642492:CLOLE RS03185
gene id: 642492:CLOLE_RS03185
uniprot id: F2JMB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

642492:CLOLE RS02495
gene id: 642492:CLOLE_RS02495
uniprot id: F2JLB1
names: Function
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Belongs to the radical SAM superfamily. NifB family.
messages: Involved in the biosynthesis of the iron-molybdenum cofactor (FeMo-co or M-cluster) found in the dinitrogenase enzyme of the nitrogenase complex in nitrogen-fixing microorganisms. NifB catalyzes the crucial step of radical SAM-dependent carbide insertion that occurs concomitant with the insertion of a 9th sulfur and the rearrangement/coupling of two [4Fe-4S] clusters into a [8Fe-9S-C] cluster, the precursor to the M-cluster.

642492:CLOLE RS15525
gene id: 642492:CLOLE_RS15525
uniprot id: F2JP61
names: Similarity
messages: Belongs to the UPF0246 family.

642492:CLOLE RS15920
gene id: 642492:CLOLE_RS15920
uniprot id: F2JPU4
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS10880
gene id: 642492:CLOLE_RS10880
uniprot id: F2JR13
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

642492:CLOLE RS02260
gene id: 642492:CLOLE_RS02260
uniprot id: F2JKJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Probably functions as a manganese efflux pump.

642492:CLOLE RS04765
gene id: 642492:CLOLE_RS04765
uniprot id: F2JQQ3
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS11270
gene id: 642492:CLOLE_RS11270
uniprot id: F2JRM4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

642492:CLOLE RS04125
gene id: 642492:CLOLE_RS04125
uniprot id: F2JPG4
names: Similarity
messages: In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
messages: In the N-terminal section; belongs to the aldehyde dehydrogenase family.

642492:CLOLE RS03505
gene id: 642492:CLOLE_RS03505
uniprot id: F2JN43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

642492:CLOLE RS14785
gene id: 642492:CLOLE_RS14785
uniprot id: F2JML1
names: Similarity
messages: Belongs to the aldose epimerase family.

642492:CLOLE RS19130
gene id: 642492:CLOLE_RS19130
uniprot id: F2JIM6
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS07695
gene id: 642492:CLOLE_RS07695
uniprot id: F2JJU8
names: Similarity
messages: Belongs to the peptidase C40 family.

642492:CLOLE RS08215
gene id: 642492:CLOLE_RS08215
uniprot id: F2JKT3
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

642492:CLOLE RS10020
gene id: 642492:CLOLE_RS10020
uniprot id: F2JPN8
names: Similarity
messages: Belongs to the diacylglycerol/lipid kinase family.

642492:CLOLE RS08610
gene id: 642492:CLOLE_RS08610
uniprot id: F2JLM4
names: Function
names: Similarity
messages: Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.

642492:CLOLE RS12270
gene id: 642492:CLOLE_RS12270
uniprot id: F2JGQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

642492:CLOLE RS21415
gene id: 642492:CLOLE_RS21415
uniprot id: F2JNQ5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

642492:CLOLE RS08755
gene id: 642492:CLOLE_RS08755
uniprot id: F2JMC6
names: Similarity
messages: Belongs to the peptidase A24 family.

642492:CLOLE RS12610
gene id: 642492:CLOLE_RS12610
uniprot id: F2JHH5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

642492:CLOLE RS08745
gene id: 642492:CLOLE_RS08745
uniprot id: F2JMC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS21650
gene id: 642492:CLOLE_RS21650
uniprot id: F2JQP7
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS10035
gene id: 642492:CLOLE_RS10035
uniprot id: F2JPP1
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

642492:CLOLE RS18030
gene id: 642492:CLOLE_RS18030
uniprot id: F2JT55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

642492:CLOLE RS19305
gene id: 642492:CLOLE_RS19305
uniprot id: F2JJD6
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

642492:CLOLE RS13050
gene id: 642492:CLOLE_RS13050
uniprot id: F2JID4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

642492:CLOLE RS01625
gene id: 642492:CLOLE_RS01625
uniprot id: F2JIV9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

642492:CLOLE RS15575
gene id: 642492:CLOLE_RS15575
uniprot id: F2JP71
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS13235
gene id: 642492:CLOLE_RS13235
uniprot id: F2JIH1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

642492:CLOLE RS15085
gene id: 642492:CLOLE_RS15085
uniprot id: F2JMR1
names: Function
names: Similarity
messages: Belongs to the PemK/MazF family.
messages: Toxic component of a type II toxin-antitoxin (TA) system.

642492:CLOLE RS17355
gene id: 642492:CLOLE_RS17355
uniprot id: F2JRW1
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS12205
gene id: 642492:CLOLE_RS12205
uniprot id: F2JGP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

642492:CLOLE RS02160
gene id: 642492:CLOLE_RS02160
uniprot id: F2JKH3
names: Similarity
messages: Belongs to the FPG family.

642492:CLOLE RS14510
gene id: 642492:CLOLE_RS14510
uniprot id: F2JLS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase D family. Cardiolipin synthase subfamily.
messages: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS01010
gene id: 642492:CLOLE_RS01010
uniprot id: F2JHX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.
messages: Catalyzes the sodium-dependent transport of glutamate.
messages: Cell membrane

642492:CLOLE RS15345
gene id: 642492:CLOLE_RS15345
uniprot id: F2JNI7
names: Subcellular Location Annotation
messages: Periplasm

642492:CLOLE RS07550
gene id: 642492:CLOLE_RS07550
uniprot id: F2JJ39
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

642492:CLOLE RS10350
gene id: 642492:CLOLE_RS10350
uniprot id: F2JQA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS21565
gene id: 642492:CLOLE_RS21565
uniprot id: F2JN28
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

642492:CLOLE RS04600
gene id: 642492:CLOLE_RS04600
uniprot id: F2JQ70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS01460
gene id: 642492:CLOLE_RS01460
uniprot id: F2JIS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS17720
gene id: 642492:CLOLE_RS17720
uniprot id: F2JSH4
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

642492:CLOLE RS17645
gene id: 642492:CLOLE_RS17645
uniprot id: F2JSF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the energy-coupling factor EcfT family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).
messages: Membrane
messages: Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.

642492:CLOLE RS17855
gene id: 642492:CLOLE_RS17855
uniprot id: F2JT20
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

642492:CLOLE RS14480
gene id: 642492:CLOLE_RS14480
uniprot id: F2JLS2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

642492:CLOLE RS02105
gene id: 642492:CLOLE_RS02105
uniprot id: F2JKG3
names: Similarity
messages: Belongs to the CapA family.

642492:CLOLE RS08985
gene id: 642492:CLOLE_RS08985
uniprot id: F2JMH4
names: Similarity
messages: Belongs to the RemA family.

642492:CLOLE RS18190
gene id: 642492:CLOLE_RS18190
uniprot id: F2JGW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

642492:CLOLE RS12430
gene id: 642492:CLOLE_RS12430
uniprot id: F2JGT6
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS07850
gene id: 642492:CLOLE_RS07850
uniprot id: F2JJY1
names: Similarity
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.

642492:CLOLE RS08310
gene id: 642492:CLOLE_RS08310
uniprot id: F2JKV2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

642492:CLOLE RS02545
gene id: 642492:CLOLE_RS02545
uniprot id: F2JLB8
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS05690
gene id: 642492:CLOLE_RS05690
uniprot id: F2JS19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

642492:CLOLE RS12625
gene id: 642492:CLOLE_RS12625
uniprot id: F2JHH8
names: Similarity
messages: Belongs to the peptidase S58 family.

642492:CLOLE RS12235
gene id: 642492:CLOLE_RS12235
uniprot id: F2JGP6
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

642492:CLOLE RS16020
gene id: 642492:CLOLE_RS16020
uniprot id: F2JPW5
names: Similarity
messages: Belongs to the PRORSD1 family.

642492:CLOLE RS18405
gene id: 642492:CLOLE_RS18405
uniprot id: F2JH13
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

642492:CLOLE RS10655
gene id: 642492:CLOLE_RS10655
uniprot id: F2JQW9
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS11715
gene id: 642492:CLOLE_RS11715
uniprot id: F2JS98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

642492:CLOLE RS07960
gene id: 642492:CLOLE_RS07960
uniprot id: F2JK03
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

642492:CLOLE RS07530
gene id: 642492:CLOLE_RS07530
uniprot id: F2JJ35
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

642492:CLOLE RS11580
gene id: 642492:CLOLE_RS11580
uniprot id: F2JS71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

642492:CLOLE RS14575
gene id: 642492:CLOLE_RS14575
uniprot id: F2JLU4
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

642492:CLOLE RS18305
gene id: 642492:CLOLE_RS18305
uniprot id: F2JGZ0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

642492:CLOLE RS12400
gene id: 642492:CLOLE_RS12400
uniprot id: F2JGS9
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

642492:CLOLE RS10920
gene id: 642492:CLOLE_RS10920
uniprot id: F2JR22
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

642492:CLOLE RS17745
gene id: 642492:CLOLE_RS17745
uniprot id: F2JSH9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

642492:CLOLE RS19250
gene id: 642492:CLOLE_RS19250
uniprot id: F2JIQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS09795
gene id: 642492:CLOLE_RS09795
uniprot id: F2JP44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

642492:CLOLE RS03760
gene id: 642492:CLOLE_RS03760
uniprot id: F2JNT8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS08885
gene id: 642492:CLOLE_RS08885
uniprot id: F2JMF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

642492:CLOLE RS12135
gene id: 642492:CLOLE_RS12135
uniprot id: F2JSZ7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

642492:CLOLE RS16195
gene id: 642492:CLOLE_RS16195
uniprot id: F2JPZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS03320
gene id: 642492:CLOLE_RS03320
uniprot id: F2JN06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0073 (Hly-III) family.
messages: Membrane

642492:CLOLE RS21075
gene id: 642492:CLOLE_RS21075
uniprot id: F2JMW1
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

642492:CLOLE RS13425
gene id: 642492:CLOLE_RS13425
uniprot id: F2JJ84
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

642492:CLOLE RS00005
gene id: 642492:CLOLE_RS00005
uniprot id: F2JSI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

642492:CLOLE RS04760
gene id: 642492:CLOLE_RS04760
uniprot id: F2JQQ2
names: Similarity
messages: Belongs to the leucine-binding protein family.

642492:CLOLE RS15940
gene id: 642492:CLOLE_RS15940
uniprot id: F2JPU8
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS00595
gene id: 642492:CLOLE_RS00595
uniprot id: F2JH39
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS07120
gene id: 642492:CLOLE_RS07120
uniprot id: F2JI83
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

642492:CLOLE RS09025
gene id: 642492:CLOLE_RS09025
uniprot id: F2JMI2
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

642492:CLOLE RS08640
gene id: 642492:CLOLE_RS08640
uniprot id: F2JLN0
names: Similarity
messages: Belongs to the peptidase S8 family.

642492:CLOLE RS13365
gene id: 642492:CLOLE_RS13365
uniprot id: F2JJ72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS15850
gene id: 642492:CLOLE_RS15850
uniprot id: F2JPC8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cleaves the N-terminal amino acid of tripeptides.
messages: Cytoplasm

642492:CLOLE RS02970
gene id: 642492:CLOLE_RS02970
uniprot id: F2JM71
names: Similarity
messages: Belongs to the dihydropyrimidine dehydrogenase family.

642492:CLOLE RS12780
gene id: 642492:CLOLE_RS12780
uniprot id: F2JHL0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

642492:CLOLE RS10355
gene id: 642492:CLOLE_RS10355
uniprot id: F2JQA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS19035
gene id: 642492:CLOLE_RS19035
uniprot id: F2JIK7
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

642492:CLOLE RS11495
gene id: 642492:CLOLE_RS11495
uniprot id: F2JS54
names: Subcellular Location Annotation
messages: Cytoplasm

642492:CLOLE RS09570
gene id: 642492:CLOLE_RS09570
uniprot id: F2JP00
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

642492:CLOLE RS13630
gene id: 642492:CLOLE_RS13630
uniprot id: F2JJC4
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

642492:CLOLE RS02030
gene id: 642492:CLOLE_RS02030
uniprot id: F2JJR7
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

642492:CLOLE RS05540
gene id: 642492:CLOLE_RS05540
uniprot id: F2JRY8
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

642492:CLOLE RS07185
gene id: 642492:CLOLE_RS07185
uniprot id: F2JI96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS15680
gene id: 642492:CLOLE_RS15680
uniprot id: F2JP93
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS12520
gene id: 642492:CLOLE_RS12520
uniprot id: F2JGV5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
messages: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

642492:CLOLE RS20275
gene id: 642492:CLOLE_RS20275
uniprot id: F2JL78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-ACP thioesterase family.
messages: chloroplast

642492:CLOLE RS20710
gene id: 642492:CLOLE_RS20710
uniprot id: F2JM26
names: Similarity
messages: Belongs to the phosphohexose mutase family.

642492:CLOLE RS00030
gene id: 642492:CLOLE_RS00030
uniprot id: F2JSI8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

642492:CLOLE RS16765
gene id: 642492:CLOLE_RS16765
uniprot id: F2JR49
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS13455
gene id: 642492:CLOLE_RS13455
uniprot id: F2JJ90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

642492:CLOLE RS05145
gene id: 642492:CLOLE_RS05145
uniprot id: F2JRC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Membrane

642492:CLOLE RS15610
gene id: 642492:CLOLE_RS15610
uniprot id: F2JP78
names: Similarity
messages: Belongs to the UPF0047 family.

642492:CLOLE RS09145
gene id: 642492:CLOLE_RS09145
uniprot id: F2JN70
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

642492:CLOLE RS10675
gene id: 642492:CLOLE_RS10675
uniprot id: F2JQX3
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS02480
gene id: 642492:CLOLE_RS02480
uniprot id: F2JLA8
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

642492:CLOLE RS05910
gene id: 642492:CLOLE_RS05910
uniprot id: F2JSN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PstS family.
messages: Cell membrane
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

642492:CLOLE RS02000
gene id: 642492:CLOLE_RS02000
uniprot id: F2JJR1
names: Similarity
messages: Belongs to the heat shock protein 90 family.

642492:CLOLE RS16790
gene id: 642492:CLOLE_RS16790
uniprot id: F2JR54
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

642492:CLOLE RS20720
gene id: 642492:CLOLE_RS20720
uniprot id: F2JM27
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

642492:CLOLE RS18200
gene id: 642492:CLOLE_RS18200
uniprot id: F2JGW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

642492:CLOLE RS06695
gene id: 642492:CLOLE_RS06695
uniprot id: F2JHC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS07880
gene id: 642492:CLOLE_RS07880
uniprot id: F2JJY7
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.

642492:CLOLE RS01550
gene id: 642492:CLOLE_RS01550
uniprot id: F2JIU4
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

642492:CLOLE RS21125
gene id: 642492:CLOLE_RS21125
uniprot id: F2JMX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

642492:CLOLE RS17195
gene id: 642492:CLOLE_RS17195
uniprot id: F2JRT1
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

642492:CLOLE RS19115
gene id: 642492:CLOLE_RS19115
uniprot id: F2JIM3
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

642492:CLOLE RS07950
gene id: 642492:CLOLE_RS07950
uniprot id: F2JK01
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS03780
gene id: 642492:CLOLE_RS03780
uniprot id: F2JNU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

642492:CLOLE RS10090
gene id: 642492:CLOLE_RS10090
uniprot id: F2JPQ0
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS12275
gene id: 642492:CLOLE_RS12275
uniprot id: F2JGQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

642492:CLOLE RS12305
gene id: 642492:CLOLE_RS12305
uniprot id: F2JGR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

642492:CLOLE RS20330
gene id: 642492:CLOLE_RS20330
uniprot id: F2JL89
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

642492:CLOLE RS10965
gene id: 642492:CLOLE_RS10965
uniprot id: F2JR31
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

642492:CLOLE RS10535
gene id: 642492:CLOLE_RS10535
uniprot id: F2JQE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

642492:CLOLE RS07315
gene id: 642492:CLOLE_RS07315
uniprot id: F2JIY9
names: Similarity
messages: Belongs to the peptidase S33 family.

642492:CLOLE RS12820
gene id: 642492:CLOLE_RS12820
uniprot id: F2JHL8
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

642492:CLOLE RS12790
gene id: 642492:CLOLE_RS12790
uniprot id: F2JHL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

642492:CLOLE RS01380
gene id: 642492:CLOLE_RS01380
uniprot id: F2JIR1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

642492:CLOLE RS14470
gene id: 642492:CLOLE_RS14470
uniprot id: F2JLS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

642492:CLOLE RS16780
gene id: 642492:CLOLE_RS16780
uniprot id: F2JR52
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

642492:CLOLE RS16190
gene id: 642492:CLOLE_RS16190
uniprot id: F2JPZ8
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

642492:CLOLE RS16645
gene id: 642492:CLOLE_RS16645
uniprot id: F2JR42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

642492:CLOLE RS14955
gene id: 642492:CLOLE_RS14955
uniprot id: F2JMP5
names: Similarity
messages: Belongs to the FBPase class 3 family.

642492:CLOLE RS17715
gene id: 642492:CLOLE_RS17715
uniprot id: F2JSH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

642492:CLOLE RS10735
gene id: 642492:CLOLE_RS10735
uniprot id: F2JQY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

642492:CLOLE RS15375
gene id: 642492:CLOLE_RS15375
uniprot id: F2JNJ3
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS18165
gene id: 642492:CLOLE_RS18165
uniprot id: F2JGW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

642492:CLOLE RS03805
gene id: 642492:CLOLE_RS03805
uniprot id: F2JNU7
names: Similarity
messages: Belongs to the thioredoxin family.

642492:CLOLE RS05180
gene id: 642492:CLOLE_RS05180
uniprot id: F2JRD1
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

642492:CLOLE RS12015
gene id: 642492:CLOLE_RS12015
uniprot id: F2JSX4
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

642492:CLOLE RS01715
gene id: 642492:CLOLE_RS01715
uniprot id: F2JJK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS18335
gene id: 642492:CLOLE_RS18335
uniprot id: F2JGZ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

642492:CLOLE RS16935
gene id: 642492:CLOLE_RS16935
uniprot id: F2JR83
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

642492:CLOLE RS20890
gene id: 642492:CLOLE_RS20890
uniprot id: F2JMS6
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

642492:CLOLE RS19240
gene id: 642492:CLOLE_RS19240
uniprot id: F2JIP8
names: Similarity
messages: Belongs to the disproportionating enzyme family.

642492:CLOLE RS21270
gene id: 642492:CLOLE_RS21270
uniprot id: F2JNM5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

642492:CLOLE RS05155
gene id: 642492:CLOLE_RS05155
uniprot id: F2JRC6
names: Function
names: Similarity
names: Subunit
messages: In the N-terminal section; belongs to the glutamate--cysteine ligase type 1 family. Type 2 subfamily.
messages: Monomer.
messages: Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine.

642492:CLOLE RS05585
gene id: 642492:CLOLE_RS05585
uniprot id: F2JRZ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.

642492:CLOLE RS06615
gene id: 642492:CLOLE_RS06615
uniprot id: F2JHB0
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

642492:CLOLE RS21030
gene id: 642492:CLOLE_RS21030
uniprot id: F2JMV2
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

642492:CLOLE RS05605
gene id: 642492:CLOLE_RS05605
uniprot id: F2JS02
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

642492:CLOLE RS03165
gene id: 642492:CLOLE_RS03165
uniprot id: F2JMA9
names: Subcellular Location Annotation
messages: Cell membrane

642492:CLOLE RS16540
gene id: 642492:CLOLE_RS16540
uniprot id: F2JQL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS07545
gene id: 642492:CLOLE_RS07545
uniprot id: F2JJ38
names: Similarity
messages: Belongs to the GARS family.

642492:CLOLE RS22195
gene id: 642492:CLOLE_RS22195
uniprot id: F2JJK5
names: Similarity
messages: Belongs to the peptidase S11 family.

642492:CLOLE RS17135
gene id: 642492:CLOLE_RS17135
uniprot id: F2JRR9
names: Similarity
messages: Belongs to the EamA transporter family.

642492:CLOLE RS09630
gene id: 642492:CLOLE_RS09630
uniprot id: F2JP12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

642492:CLOLE RS16495
gene id: 642492:CLOLE_RS16495
uniprot id: F2JQK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

642492:CLOLE RS09995
gene id: 642492:CLOLE_RS09995
uniprot id: F2JPN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

642492:CLOLE RS11450
gene id: 642492:CLOLE_RS11450
uniprot id: F2JS45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ScpB family.
messages: Cytoplasm
messages: Homodimer. Homodimerization may be required to stabilize the binding of ScpA to the Smc head domains. Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.
messages: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.

642492:CLOLE RS06905
gene id: 642492:CLOLE_RS06905
uniprot id: F2JI39
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS02665
gene id: 642492:CLOLE_RS02665
uniprot id: F2JLD7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

642492:CLOLE RS05335
gene id: 642492:CLOLE_RS05335
uniprot id: F2JRG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

642492:CLOLE RS08045
gene id: 642492:CLOLE_RS08045
uniprot id: F2JKP9
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

642492:CLOLE RS02660
gene id: 642492:CLOLE_RS02660
uniprot id: F2JLD6
names: Similarity
messages: Belongs to the glycosyl hydrolase 9 (cellulase E) family.

642492:CLOLE RS12355
gene id: 642492:CLOLE_RS12355
uniprot id: F2JGS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS10410
gene id: 642492:CLOLE_RS10410
uniprot id: F2JQB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

642492:CLOLE RS17870
gene id: 642492:CLOLE_RS17870
uniprot id: F2JT23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

642492:CLOLE RS08225
gene id: 642492:CLOLE_RS08225
uniprot id: F2JKT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

642492:CLOLE RS17780
gene id: 642492:CLOLE_RS17780
uniprot id: F2JT05
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

642492:CLOLE RS03100
gene id: 642492:CLOLE_RS03100
uniprot id: F2JM96
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS14530
gene id: 642492:CLOLE_RS14530
uniprot id: F2JLT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

642492:CLOLE RS03480
gene id: 642492:CLOLE_RS03480
uniprot id: F2JN38
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS16535
gene id: 642492:CLOLE_RS16535
uniprot id: F2JQL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS00570
gene id: 642492:CLOLE_RS00570
uniprot id: F2JGF2
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

642492:CLOLE RS20295
gene id: 642492:CLOLE_RS20295
uniprot id: F2JL82
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

642492:CLOLE RS10730
gene id: 642492:CLOLE_RS10730
uniprot id: F2JQY3
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

642492:CLOLE RS09325
gene id: 642492:CLOLE_RS09325
uniprot id: F2JNA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta sliding clamp family.
messages: Cytoplasm

642492:CLOLE RS02415
gene id: 642492:CLOLE_RS02415
uniprot id: F2JKM3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

642492:CLOLE RS03180
gene id: 642492:CLOLE_RS03180
uniprot id: F2JMB2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

642492:CLOLE RS07425
gene id: 642492:CLOLE_RS07425
uniprot id: F2JJ13
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

642492:CLOLE RS17385
gene id: 642492:CLOLE_RS17385
uniprot id: F2JRW7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS09000
gene id: 642492:CLOLE_RS09000
uniprot id: F2JMH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

642492:CLOLE RS18315
gene id: 642492:CLOLE_RS18315
uniprot id: F2JGZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

642492:CLOLE RS05210
gene id: 642492:CLOLE_RS05210
uniprot id: F2JRD7
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS10555
gene id: 642492:CLOLE_RS10555
uniprot id: F2JQE5
names: Similarity
messages: Belongs to the UPF0758 family.

642492:CLOLE RS06360
gene id: 642492:CLOLE_RS06360
uniprot id: F2JGK2
names: Similarity
messages: Belongs to the CAPAB/TerDEXZ family.

642492:CLOLE RS14600
gene id: 642492:CLOLE_RS14600
uniprot id: F2JLU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

642492:CLOLE RS20405
gene id: 642492:CLOLE_RS20405
uniprot id: F2JLA4
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

642492:CLOLE RS20310
gene id: 642492:CLOLE_RS20310
uniprot id: F2JL85
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS19700
gene id: 642492:CLOLE_RS19700
uniprot id: F2JK93
names: Similarity
messages: Belongs to the Nudix hydrolase family.

642492:CLOLE RS09010
gene id: 642492:CLOLE_RS09010
uniprot id: F2JMH9
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

642492:CLOLE RS16880
gene id: 642492:CLOLE_RS16880
uniprot id: F2JR72
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

642492:CLOLE RS12180
gene id: 642492:CLOLE_RS12180
uniprot id: F2JGN5
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS21300
gene id: 642492:CLOLE_RS21300
uniprot id: F2JNN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
messages: Homodimer.
messages: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.

642492:CLOLE RS09210
gene id: 642492:CLOLE_RS09210
uniprot id: F2JN84
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS03895
gene id: 642492:CLOLE_RS03895
uniprot id: F2JNW7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

642492:CLOLE RS18100
gene id: 642492:CLOLE_RS18100
uniprot id: F2JT69
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

642492:CLOLE RS07510
gene id: 642492:CLOLE_RS07510
uniprot id: F2JJ31
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

642492:CLOLE RS12200
gene id: 642492:CLOLE_RS12200
uniprot id: F2JGN9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS13075
gene id: 642492:CLOLE_RS13075
uniprot id: F2JID8
names: Similarity
messages: Belongs to the prephenate/arogenate dehydrogenase family.

642492:CLOLE RS20765
gene id: 642492:CLOLE_RS20765
uniprot id: F2JM36
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

642492:CLOLE RS02100
gene id: 642492:CLOLE_RS02100
uniprot id: F2JJT0
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

642492:CLOLE RS02945
gene id: 642492:CLOLE_RS02945
uniprot id: F2JM67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS18110
gene id: 642492:CLOLE_RS18110
uniprot id: F2JT71
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS14155
gene id: 642492:CLOLE_RS14155
uniprot id: F2JKZ4
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

642492:CLOLE RS17565
gene id: 642492:CLOLE_RS17565
uniprot id: F2JSE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

642492:CLOLE RS16520
gene id: 642492:CLOLE_RS16520
uniprot id: F2JQL4
names: Similarity
messages: Belongs to the ArsC family.

642492:CLOLE RS03810
gene id: 642492:CLOLE_RS03810
uniprot id: F2JNU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

642492:CLOLE RS17650
gene id: 642492:CLOLE_RS17650
uniprot id: F2JSG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).
messages: Membrane

642492:CLOLE RS14865
gene id: 642492:CLOLE_RS14865
uniprot id: F2JMM6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.

642492:CLOLE RS14170
gene id: 642492:CLOLE_RS14170
uniprot id: F2JKZ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS00290
gene id: 642492:CLOLE_RS00290
uniprot id: F2JGB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic sulfate-binding protein family.
messages: Periplasm

642492:CLOLE RS14275
gene id: 642492:CLOLE_RS14275
uniprot id: F2JL17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

642492:CLOLE RS17630
gene id: 642492:CLOLE_RS17630
uniprot id: F2JSF6
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

642492:CLOLE RS05835
gene id: 642492:CLOLE_RS05835
uniprot id: F2JSL8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

642492:CLOLE RS05960
gene id: 642492:CLOLE_RS05960
uniprot id: F2JSP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

642492:CLOLE RS07745
gene id: 642492:CLOLE_RS07745
uniprot id: F2JJV8
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

642492:CLOLE RS18275
gene id: 642492:CLOLE_RS18275
uniprot id: F2JGY4
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

642492:CLOLE RS10395
gene id: 642492:CLOLE_RS10395
uniprot id: F2JQB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

642492:CLOLE RS11865
gene id: 642492:CLOLE_RS11865
uniprot id: F2JSU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

642492:CLOLE RS03520
gene id: 642492:CLOLE_RS03520
uniprot id: F2JN46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

642492:CLOLE RS05205
gene id: 642492:CLOLE_RS05205
uniprot id: F2JRD6
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

642492:CLOLE RS10905
gene id: 642492:CLOLE_RS10905
uniprot id: F2JR19
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

642492:CLOLE RS11465
gene id: 642492:CLOLE_RS11465
uniprot id: F2JS48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.
messages: Homodimer.

642492:CLOLE RS06610
gene id: 642492:CLOLE_RS06610
uniprot id: F2JHA9
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

642492:CLOLE RS05950
gene id: 642492:CLOLE_RS05950
uniprot id: F2JSN9
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

642492:CLOLE RS11960
gene id: 642492:CLOLE_RS11960
uniprot id: F2JSW3
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS01545
gene id: 642492:CLOLE_RS01545
uniprot id: F2JIU3
names: Similarity
messages: Belongs to the CarB family.

642492:CLOLE RS21370
gene id: 642492:CLOLE_RS21370
uniprot id: F2JNP6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

642492:CLOLE RS17790
gene id: 642492:CLOLE_RS17790
uniprot id: F2JT07
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

642492:CLOLE RS00890
gene id: 642492:CLOLE_RS00890
uniprot id: F2JH74
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS12785
gene id: 642492:CLOLE_RS12785
uniprot id: F2JHL1
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

642492:CLOLE RS01410
gene id: 642492:CLOLE_RS01410
uniprot id: F2JIR7
names: Similarity
messages: Belongs to the Nudix hydrolase family.

642492:CLOLE RS02885
gene id: 642492:CLOLE_RS02885
uniprot id: F2JM55
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

642492:CLOLE RS20935
gene id: 642492:CLOLE_RS20935
uniprot id: F2JMT5
names: Similarity
messages: Belongs to the arsA ATPase family.

642492:CLOLE RS20500
gene id: 642492:CLOLE_RS20500
uniprot id: F2JLY8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial microcompartment
messages: Belongs to the EutB family.
messages: Binds between the large and small subunits.
messages: Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of vitamin B12.
messages: The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.

642492:CLOLE RS08295
gene id: 642492:CLOLE_RS08295
uniprot id: F2JKU9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

642492:CLOLE RS16760
gene id: 642492:CLOLE_RS16760
uniprot id: F2JR48
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

642492:CLOLE RS11525
gene id: 642492:CLOLE_RS11525
uniprot id: F2JS60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

642492:CLOLE RS09165
gene id: 642492:CLOLE_RS09165
uniprot id: F2JN74
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

642492:CLOLE RS11640
gene id: 642492:CLOLE_RS11640
uniprot id: F2JS83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

642492:CLOLE RS03365
gene id: 642492:CLOLE_RS03365
uniprot id: F2JN15
names: Similarity
messages: Belongs to the CFA/CMAS family.

642492:CLOLE RS21780
gene id: 642492:CLOLE_RS21780
uniprot id: F2JKQ4
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS14900
gene id: 642492:CLOLE_RS14900
uniprot id: F2JMN3
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

642492:CLOLE RS17995
gene id: 642492:CLOLE_RS17995
uniprot id: F2JT48
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

642492:CLOLE RS01145
gene id: 642492:CLOLE_RS01145
uniprot id: F2JHZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

642492:CLOLE RS15420
gene id: 642492:CLOLE_RS15420
uniprot id: F2JNK2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

642492:CLOLE RS19220
gene id: 642492:CLOLE_RS19220
uniprot id: F2JIP4
names: Similarity
messages: Belongs to the GerABKA family.

642492:CLOLE RS00100
gene id: 642492:CLOLE_RS00100
uniprot id: F2JSJ0
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

642492:CLOLE RS08515
gene id: 642492:CLOLE_RS08515
uniprot id: F2JLK5
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS08095
gene id: 642492:CLOLE_RS08095
uniprot id: F2JKQ9
names: Similarity
messages: Belongs to the DCK/DGK family.

642492:CLOLE RS18020
gene id: 642492:CLOLE_RS18020
uniprot id: F2JT53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

642492:CLOLE RS19715
gene id: 642492:CLOLE_RS19715
uniprot id: F2JK96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

642492:CLOLE RS21880
gene id: 642492:CLOLE_RS21880
uniprot id: F2JST4
names: Similarity
messages: Belongs to the MscS (TC 1.A.23) family.

642492:CLOLE RS05895
gene id: 642492:CLOLE_RS05895
uniprot id: F2JSM8
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS18125
gene id: 642492:CLOLE_RS18125
uniprot id: F2JT74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Membrane

642492:CLOLE RS12370
gene id: 642492:CLOLE_RS12370
uniprot id: F2JGS3
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Membrane

642492:CLOLE RS13210
gene id: 642492:CLOLE_RS13210
uniprot id: F2JIG6
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS14960
gene id: 642492:CLOLE_RS14960
uniprot id: F2JMP6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS08210
gene id: 642492:CLOLE_RS08210
uniprot id: F2JKT2
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

642492:CLOLE RS20575
gene id: 642492:CLOLE_RS20575
uniprot id: F2JM03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.
messages: Catalyzes the sodium-dependent transport of glutamate.
messages: Cell membrane

642492:CLOLE RS07930
gene id: 642492:CLOLE_RS07930
uniprot id: F2JJZ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.
messages: Cytoplasm
messages: Homodimer.

642492:CLOLE RS21175
gene id: 642492:CLOLE_RS21175
uniprot id: F2JMY0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

642492:CLOLE RS18270
gene id: 642492:CLOLE_RS18270
uniprot id: F2JGY3
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

642492:CLOLE RS01140
gene id: 642492:CLOLE_RS01140
uniprot id: F2JHZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

642492:CLOLE RS11990
gene id: 642492:CLOLE_RS11990
uniprot id: F2JSW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

642492:CLOLE RS10100
gene id: 642492:CLOLE_RS10100
uniprot id: F2JPQ2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

642492:CLOLE RS10485
gene id: 642492:CLOLE_RS10485
uniprot id: F2JQD1
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS10390
gene id: 642492:CLOLE_RS10390
uniprot id: F2JQB1
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

642492:CLOLE RS21000
gene id: 642492:CLOLE_RS21000
uniprot id: F2JMU8
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS20335
gene id: 642492:CLOLE_RS20335
uniprot id: F2JL90
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

642492:CLOLE RS01285
gene id: 642492:CLOLE_RS01285
uniprot id: F2JI20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS14135
gene id: 642492:CLOLE_RS14135
uniprot id: F2JKZ0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

642492:CLOLE RS11520
gene id: 642492:CLOLE_RS11520
uniprot id: F2JS59
names: Function
names: Subcellular Location Annotation
messages: ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
messages: Cytoplasm

642492:CLOLE RS06775
gene id: 642492:CLOLE_RS06775
uniprot id: F2JHE5
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

642492:CLOLE RS16110
gene id: 642492:CLOLE_RS16110
uniprot id: F2JPY3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

642492:CLOLE RS11620
gene id: 642492:CLOLE_RS11620
uniprot id: F2JS79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

642492:CLOLE RS17865
gene id: 642492:CLOLE_RS17865
uniprot id: F2JT22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

642492:CLOLE RS06405
gene id: 642492:CLOLE_RS06405
uniprot id: F2JGL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS12670
gene id: 642492:CLOLE_RS12670
uniprot id: F2JHI7
names: Similarity
messages: Belongs to the DEAD box helicase family.

642492:CLOLE RS11365
gene id: 642492:CLOLE_RS11365
uniprot id: F2JRP3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.

642492:CLOLE RS09755
gene id: 642492:CLOLE_RS09755
uniprot id: F2JP36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS05295
gene id: 642492:CLOLE_RS05295
uniprot id: F2JRF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

642492:CLOLE RS13190
gene id: 642492:CLOLE_RS13190
uniprot id: F2JIG3
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

642492:CLOLE RS09190
gene id: 642492:CLOLE_RS09190
uniprot id: F2JN80
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

642492:CLOLE RS05755
gene id: 642492:CLOLE_RS05755
uniprot id: F2JS31
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

642492:CLOLE RS19385
gene id: 642492:CLOLE_RS19385
uniprot id: F2JJF2
names: Similarity
messages: In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
messages: In the N-terminal section; belongs to the aldehyde dehydrogenase family.

642492:CLOLE RS07995
gene id: 642492:CLOLE_RS07995
uniprot id: F2JKN9
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS16840
gene id: 642492:CLOLE_RS16840
uniprot id: F2JR64
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

642492:CLOLE RS05390
gene id: 642492:CLOLE_RS05390
uniprot id: F2JRW9
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS14150
gene id: 642492:CLOLE_RS14150
uniprot id: F2JKZ3
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

642492:CLOLE RS18465
gene id: 642492:CLOLE_RS18465
uniprot id: F2JH25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

642492:CLOLE RS10025
gene id: 642492:CLOLE_RS10025
uniprot id: F2JPN9
names: Similarity
messages: Belongs to the UPF0340 family.

642492:CLOLE RS02905
gene id: 642492:CLOLE_RS02905
uniprot id: F2JM59
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

642492:CLOLE RS16275
gene id: 642492:CLOLE_RS16275
uniprot id: F2JQG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

642492:CLOLE RS06030
gene id: 642492:CLOLE_RS06030
uniprot id: F2JSQ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

642492:CLOLE RS16985
gene id: 642492:CLOLE_RS16985
uniprot id: F2JR93
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

642492:CLOLE RS16075
gene id: 642492:CLOLE_RS16075
uniprot id: F2JPX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

642492:CLOLE RS08205
gene id: 642492:CLOLE_RS08205
uniprot id: F2JKT1
names: Similarity
messages: Belongs to the UPF0735 family.

642492:CLOLE RS14705
gene id: 642492:CLOLE_RS14705
uniprot id: F2JLW9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS11470
gene id: 642492:CLOLE_RS11470
uniprot id: F2JS49
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

642492:CLOLE RS19965
gene id: 642492:CLOLE_RS19965
uniprot id: F2JKE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS03090
gene id: 642492:CLOLE_RS03090
uniprot id: F2JM94
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

642492:CLOLE RS14840
gene id: 642492:CLOLE_RS14840
uniprot id: F2JMM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

642492:CLOLE RS18345
gene id: 642492:CLOLE_RS18345
uniprot id: F2JGZ8
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

642492:CLOLE RS21035
gene id: 642492:CLOLE_RS21035
uniprot id: F2JMV3
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

642492:CLOLE RS06225
gene id: 642492:CLOLE_RS06225
uniprot id: F2JGH4
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS17140
gene id: 642492:CLOLE_RS17140
uniprot id: F2JRS0
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

642492:CLOLE RS02790
gene id: 642492:CLOLE_RS02790
uniprot id: F2JLG0
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS08245
gene id: 642492:CLOLE_RS08245
uniprot id: F2JKT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.
messages: Cell membrane
messages: Membrane
messages: Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex.

642492:CLOLE RS15720
gene id: 642492:CLOLE_RS15720
uniprot id: F2JPA2
names: Similarity
messages: Belongs to the ThiD family.

642492:CLOLE RS09750
gene id: 642492:CLOLE_RS09750
uniprot id: F2JP35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.

642492:CLOLE RS09040
gene id: 642492:CLOLE_RS09040
uniprot id: F2JMI5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

642492:CLOLE RS08160
gene id: 642492:CLOLE_RS08160
uniprot id: F2JKS2
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

642492:CLOLE RS12815
gene id: 642492:CLOLE_RS12815
uniprot id: F2JHL7
names: Similarity
messages: Belongs to the thioredoxin family.

642492:CLOLE RS16335
gene id: 642492:CLOLE_RS16335
uniprot id: F2JQH7
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

642492:CLOLE RS06850
gene id: 642492:CLOLE_RS06850
uniprot id: F2JHF8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

642492:CLOLE RS09800
gene id: 642492:CLOLE_RS09800
uniprot id: F2JP45
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS10520
gene id: 642492:CLOLE_RS10520
uniprot id: F2JQD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

642492:CLOLE RS00655
gene id: 642492:CLOLE_RS00655
uniprot id: F2JH47
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS01005
gene id: 642492:CLOLE_RS01005
uniprot id: F2JHW9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

642492:CLOLE RS08990
gene id: 642492:CLOLE_RS08990
uniprot id: F2JMH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

642492:CLOLE RS14550
gene id: 642492:CLOLE_RS14550
uniprot id: F2JLT7
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

642492:CLOLE RS02055
gene id: 642492:CLOLE_RS02055
uniprot id: F2JJS2
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

642492:CLOLE RS20175
gene id: 642492:CLOLE_RS20175
uniprot id: F2JL58
names: Function
names: Similarity
messages: Belongs to the LuxC family.
messages: LuxC is the fatty acid reductase enzyme responsible for synthesis of the aldehyde substrate for the luminescent reaction catalyzed by luciferase.

642492:CLOLE RS10720
gene id: 642492:CLOLE_RS10720
uniprot id: F2JQY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

642492:CLOLE RS08740
gene id: 642492:CLOLE_RS08740
uniprot id: F2JMC3
names: Similarity
messages: Belongs to the GSP E family.

642492:CLOLE RS20865
gene id: 642492:CLOLE_RS20865
uniprot id: F2JMS1
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

642492:CLOLE RS06345
gene id: 642492:CLOLE_RS06345
uniprot id: F2JGJ9
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

642492:CLOLE RS04420
gene id: 642492:CLOLE_RS04420
uniprot id: F2JQ33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

642492:CLOLE RS17800
gene id: 642492:CLOLE_RS17800
uniprot id: F2JT09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

642492:CLOLE RS15460
gene id: 642492:CLOLE_RS15460
uniprot id: F2JNL1
names: Similarity
messages: Belongs to the peptidase S66 family.

642492:CLOLE RS03715
gene id: 642492:CLOLE_RS03715
uniprot id: F2JNS9
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

642492:CLOLE RS18435
gene id: 642492:CLOLE_RS18435
uniprot id: F2JH19
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

642492:CLOLE RS11785
gene id: 642492:CLOLE_RS11785
uniprot id: F2JST0
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

642492:CLOLE RS14270
gene id: 642492:CLOLE_RS14270
uniprot id: F2JL16
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

642492:CLOLE RS03645
gene id: 642492:CLOLE_RS03645
uniprot id: F2JNR5
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS11180
gene id: 642492:CLOLE_RS11180
uniprot id: F2JRK7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

642492:CLOLE RS14890
gene id: 642492:CLOLE_RS14890
uniprot id: F2JMN1
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS14580
gene id: 642492:CLOLE_RS14580
uniprot id: F2JLU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

642492:CLOLE RS14860
gene id: 642492:CLOLE_RS14860
uniprot id: F2JMM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

642492:CLOLE RS07110
gene id: 642492:CLOLE_RS07110
uniprot id: F2JI81
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

642492:CLOLE RS21995
gene id: 642492:CLOLE_RS21995
uniprot id: F2JGM4
names: Similarity
messages: Belongs to the transposase 11 family.

642492:CLOLE RS07000
gene id: 642492:CLOLE_RS07000
uniprot id: F2JI58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

642492:CLOLE RS13565
gene id: 642492:CLOLE_RS13565
uniprot id: F2JJB2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

642492:CLOLE RS06520
gene id: 642492:CLOLE_RS06520
uniprot id: F2JH91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

642492:CLOLE RS14800
gene id: 642492:CLOLE_RS14800
uniprot id: F2JML4
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

642492:CLOLE RS01925
gene id: 642492:CLOLE_RS01925
uniprot id: F2JJP6
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS14695
gene id: 642492:CLOLE_RS14695
uniprot id: F2JLW7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

642492:CLOLE RS04120
gene id: 642492:CLOLE_RS04120
uniprot id: F2JPG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

642492:CLOLE RS12375
gene id: 642492:CLOLE_RS12375
uniprot id: F2JGS4
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane

642492:CLOLE RS21395
gene id: 642492:CLOLE_RS21395
uniprot id: F2JNQ1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpA which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpB RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpA.
messages: Has an N-terminal Jag-N domain and 2 RNA-binding domains (KH and R3H).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS05545
gene id: 642492:CLOLE_RS05545
uniprot id: F2JRY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

642492:CLOLE RS10850
gene id: 642492:CLOLE_RS10850
uniprot id: F2JR07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YejK family.
messages: nucleoid

642492:CLOLE RS08880
gene id: 642492:CLOLE_RS08880
uniprot id: F2JMF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

642492:CLOLE RS11460
gene id: 642492:CLOLE_RS11460
uniprot id: F2JS47
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

642492:CLOLE RS05965
gene id: 642492:CLOLE_RS05965
uniprot id: F2JSP2
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS04490
gene id: 642492:CLOLE_RS04490
uniprot id: F2JQ46
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

642492:CLOLE RS08190
gene id: 642492:CLOLE_RS08190
uniprot id: F2JKS8
names: Similarity
messages: Belongs to the BMP lipoprotein family.

642492:CLOLE RS11680
gene id: 642492:CLOLE_RS11680
uniprot id: F2JS91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

642492:CLOLE RS01930
gene id: 642492:CLOLE_RS01930
uniprot id: F2JJP7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

642492:CLOLE RS14740
gene id: 642492:CLOLE_RS14740
uniprot id: F2JMK1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

642492:CLOLE RS13495
gene id: 642492:CLOLE_RS13495
uniprot id: F2JJ98
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS15330
gene id: 642492:CLOLE_RS15330
uniprot id: F2JNI4
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS20345
gene id: 642492:CLOLE_RS20345
uniprot id: F2JL92
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

642492:CLOLE RS18755
gene id: 642492:CLOLE_RS18755
uniprot id: F2JHS7
names: Similarity
messages: Belongs to the WXG100 family.

642492:CLOLE RS11445
gene id: 642492:CLOLE_RS11445
uniprot id: F2JS44
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

642492:CLOLE RS02995
gene id: 642492:CLOLE_RS02995
uniprot id: F2JM75
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS14810
gene id: 642492:CLOLE_RS14810
uniprot id: F2JML6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS07435
gene id: 642492:CLOLE_RS07435
uniprot id: F2JJ15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS10120
gene id: 642492:CLOLE_RS10120
uniprot id: F2JPQ8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

642492:CLOLE RS16095
gene id: 642492:CLOLE_RS16095
uniprot id: F2JPY0
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS09080
gene id: 642492:CLOLE_RS09080
uniprot id: F2JMJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

642492:CLOLE RS15255
gene id: 642492:CLOLE_RS15255
uniprot id: F2JNG9
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

642492:CLOLE RS14160
gene id: 642492:CLOLE_RS14160
uniprot id: F2JKZ5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

642492:CLOLE RS02890
gene id: 642492:CLOLE_RS02890
uniprot id: F2JM56
names: Similarity
messages: Belongs to the aldose epimerase family.

642492:CLOLE RS05480
gene id: 642492:CLOLE_RS05480
uniprot id: F2JRY5
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS06010
gene id: 642492:CLOLE_RS06010
uniprot id: F2JSQ2
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

642492:CLOLE RS15585
gene id: 642492:CLOLE_RS15585
uniprot id: F2JP73
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Homodimer.
messages: Secreted

642492:CLOLE RS06975
gene id: 642492:CLOLE_RS06975
uniprot id: F2JI53
names: Similarity
messages: Belongs to the threonine synthase family.

642492:CLOLE RS14215
gene id: 642492:CLOLE_RS14215
uniprot id: F2JL06
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS05610
gene id: 642492:CLOLE_RS05610
uniprot id: F2JS03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

642492:CLOLE RS17165
gene id: 642492:CLOLE_RS17165
uniprot id: F2JRS5
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

642492:CLOLE RS03360
gene id: 642492:CLOLE_RS03360
uniprot id: F2JN14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LPG synthase family.
messages: Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS17660
gene id: 642492:CLOLE_RS17660
uniprot id: F2JSG2
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

642492:CLOLE RS07395
gene id: 642492:CLOLE_RS07395
uniprot id: F2JJ07
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS12595
gene id: 642492:CLOLE_RS12595
uniprot id: F2JHH2
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS17830
gene id: 642492:CLOLE_RS17830
uniprot id: F2JT15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

642492:CLOLE RS13875
gene id: 642492:CLOLE_RS13875
uniprot id: F2JK52
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

642492:CLOLE RS08260
gene id: 642492:CLOLE_RS08260
uniprot id: F2JKU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

642492:CLOLE RS02475
gene id: 642492:CLOLE_RS02475
uniprot id: F2JKN5
names: Similarity
messages: Belongs to the P(II) protein family.

642492:CLOLE RS05245
gene id: 642492:CLOLE_RS05245
uniprot id: F2JRE4
names: Similarity
messages: Belongs to the pyruvate kinase family.
messages: In the C-terminal section; belongs to the PEP-utilizing enzyme family.

642492:CLOLE RS17685
gene id: 642492:CLOLE_RS17685
uniprot id: F2JSG7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

642492:CLOLE RS12910
gene id: 642492:CLOLE_RS12910
uniprot id: F2JHN3
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS10075
gene id: 642492:CLOLE_RS10075
uniprot id: F2JPP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

642492:CLOLE RS15280
gene id: 642492:CLOLE_RS15280
uniprot id: F2JNH4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

642492:CLOLE RS19580
gene id: 642492:CLOLE_RS19580
uniprot id: F2JJJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

642492:CLOLE RS06300
gene id: 642492:CLOLE_RS06300
uniprot id: F2JGJ0
names: Similarity
messages: Belongs to the UxaA family.

642492:CLOLE RS19235
gene id: 642492:CLOLE_RS19235
uniprot id: F2JIP7
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

642492:CLOLE RS17900
gene id: 642492:CLOLE_RS17900
uniprot id: F2JT29
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

642492:CLOLE RS09680
gene id: 642492:CLOLE_RS09680
uniprot id: F2JP22
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

642492:CLOLE RS05565
gene id: 642492:CLOLE_RS05565
uniprot id: F2JRZ3
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

642492:CLOLE RS07795
gene id: 642492:CLOLE_RS07795
uniprot id: F2JJX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS04475
gene id: 642492:CLOLE_RS04475
uniprot id: F2JQ44
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS00020
gene id: 642492:CLOLE_RS00020
uniprot id: F2JSI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

642492:CLOLE RS19510
gene id: 642492:CLOLE_RS19510
uniprot id: F2JJH6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

642492:CLOLE RS19830
gene id: 642492:CLOLE_RS19830
uniprot id: F2JKB7
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

642492:CLOLE RS03305
gene id: 642492:CLOLE_RS03305
uniprot id: F2JN03
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

642492:CLOLE RS07020
gene id: 642492:CLOLE_RS07020
uniprot id: F2JI62
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.

642492:CLOLE RS12580
gene id: 642492:CLOLE_RS12580
uniprot id: F2JHG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS19300
gene id: 642492:CLOLE_RS19300
uniprot id: F2JJD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

642492:CLOLE RS20435
gene id: 642492:CLOLE_RS20435
uniprot id: F2JLX5
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS08575
gene id: 642492:CLOLE_RS08575
uniprot id: F2JLL7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

642492:CLOLE RS13220
gene id: 642492:CLOLE_RS13220
uniprot id: F2JIG8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

642492:CLOLE RS08705
gene id: 642492:CLOLE_RS08705
uniprot id: F2JLP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

642492:CLOLE RS09895
gene id: 642492:CLOLE_RS09895
uniprot id: F2JPL3
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

642492:CLOLE RS07115
gene id: 642492:CLOLE_RS07115
uniprot id: F2JI82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

642492:CLOLE RS18885
gene id: 642492:CLOLE_RS18885
uniprot id: F2JHV4
names: Similarity
messages: Belongs to the GSP E family.

642492:CLOLE RS14805
gene id: 642492:CLOLE_RS14805
uniprot id: F2JML5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.
messages: Cytoplasm

642492:CLOLE RS17120
gene id: 642492:CLOLE_RS17120
uniprot id: F2JRR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

642492:CLOLE RS04250
gene id: 642492:CLOLE_RS04250
uniprot id: F2JPJ6
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

642492:CLOLE RS05160
gene id: 642492:CLOLE_RS05160
uniprot id: F2JRC7
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

642492:CLOLE RS14235
gene id: 642492:CLOLE_RS14235
uniprot id: F2JL10
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

642492:CLOLE RS10830
gene id: 642492:CLOLE_RS10830
uniprot id: F2JR03
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

642492:CLOLE RS11690
gene id: 642492:CLOLE_RS11690
uniprot id: F2JS93
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

642492:CLOLE RS17185
gene id: 642492:CLOLE_RS17185
uniprot id: F2JRS9
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

642492:CLOLE RS17105
gene id: 642492:CLOLE_RS17105
uniprot id: F2JRR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS11275
gene id: 642492:CLOLE_RS11275
uniprot id: F2JRM5
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS02765
gene id: 642492:CLOLE_RS02765
uniprot id: F2JLF5
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS12130
gene id: 642492:CLOLE_RS12130
uniprot id: F2JSZ6
names: Similarity
messages: Belongs to the ribF family.

642492:CLOLE RS15435
gene id: 642492:CLOLE_RS15435
uniprot id: F2JNK6
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS06355
gene id: 642492:CLOLE_RS06355
uniprot id: F2JGK1
names: Similarity
messages: Belongs to the CAPAB/TerDEXZ family.

642492:CLOLE RS18285
gene id: 642492:CLOLE_RS18285
uniprot id: F2JGY6
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS18735
gene id: 642492:CLOLE_RS18735
uniprot id: F2JHS3
names: Similarity
messages: Belongs to the peptidase C40 family.

642492:CLOLE RS04705
gene id: 642492:CLOLE_RS04705
uniprot id: F2JQP3
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

642492:CLOLE RS17110
gene id: 642492:CLOLE_RS17110
uniprot id: F2JRR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS08125
gene id: 642492:CLOLE_RS08125
uniprot id: F2JKR5
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

642492:CLOLE RS13545
gene id: 642492:CLOLE_RS13545
uniprot id: F2JJA8
names: Similarity
messages: Belongs to the EamA transporter family.

642492:CLOLE RS02115
gene id: 642492:CLOLE_RS02115
uniprot id: F2JKG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS19145
gene id: 642492:CLOLE_RS19145
uniprot id: F2JIM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

642492:CLOLE RS20925
gene id: 642492:CLOLE_RS20925
uniprot id: F2JMT3
names: Similarity
messages: Belongs to the arsA ATPase family.

642492:CLOLE RS11860
gene id: 642492:CLOLE_RS11860
uniprot id: F2JSU5
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

642492:CLOLE RS05340
gene id: 642492:CLOLE_RS05340
uniprot id: F2JRG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

642492:CLOLE RS07415
gene id: 642492:CLOLE_RS07415
uniprot id: F2JJ11
names: Similarity
messages: Belongs to the peptidase M29 family.

642492:CLOLE RS13460
gene id: 642492:CLOLE_RS13460
uniprot id: F2JJ91
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

642492:CLOLE RS10140
gene id: 642492:CLOLE_RS10140
uniprot id: F2JPR3
names: Similarity
messages: Belongs to the LacAB/RpiB family.

642492:CLOLE RS13320
gene id: 642492:CLOLE_RS13320
uniprot id: F2JJ62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diaminopimelate dehydrogenase family.
messages: Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D,L-2,6-diaminopimelate.
messages: Homodimer.

642492:CLOLE RS20075
gene id: 642492:CLOLE_RS20075
uniprot id: F2JL38
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS09565
gene id: 642492:CLOLE_RS09565
uniprot id: F2JNZ9
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

642492:CLOLE RS02725
gene id: 642492:CLOLE_RS02725
uniprot id: F2JLE8
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

642492:CLOLE RS11870
gene id: 642492:CLOLE_RS11870
uniprot id: F2JSU7
names: Similarity
messages: Belongs to the zinc-associated anti-sigma factor (ZAS) superfamily. Anti-sigma-W factor family.

642492:CLOLE RS11740
gene id: 642492:CLOLE_RS11740
uniprot id: F2JSA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS02910
gene id: 642492:CLOLE_RS02910
uniprot id: F2JM60
names: Cofactor
names: Similarity
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.

642492:CLOLE RS02025
gene id: 642492:CLOLE_RS02025
uniprot id: F2JJR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS13400
gene id: 642492:CLOLE_RS13400
uniprot id: F2JJ79
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS10760
gene id: 642492:CLOLE_RS10760
uniprot id: F2JQY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

642492:CLOLE RS18415
gene id: 642492:CLOLE_RS18415
uniprot id: F2JH15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

642492:CLOLE RS01910
gene id: 642492:CLOLE_RS01910
uniprot id: F2JJP3
names: Similarity
messages: Belongs to the BMP lipoprotein family.

642492:CLOLE RS11605
gene id: 642492:CLOLE_RS11605
uniprot id: F2JS76
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

642492:CLOLE RS17315
gene id: 642492:CLOLE_RS17315
uniprot id: F2JRV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

642492:CLOLE RS05975
gene id: 642492:CLOLE_RS05975
uniprot id: F2JSP4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS14940
gene id: 642492:CLOLE_RS14940
uniprot id: F2JMP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

642492:CLOLE RS00950
gene id: 642492:CLOLE_RS00950
uniprot id: F2JH87
names: Similarity
messages: Belongs to the catalase family.

642492:CLOLE RS19910
gene id: 642492:CLOLE_RS19910
uniprot id: F2JKD4
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.
messages: Homotetramer.

642492:CLOLE RS08320
gene id: 642492:CLOLE_RS08320
uniprot id: F2JKV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0053 family.
messages: Membrane

642492:CLOLE RS10580
gene id: 642492:CLOLE_RS10580
uniprot id: F2JQF0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

642492:CLOLE RS19410
gene id: 642492:CLOLE_RS19410
uniprot id: F2JJF7
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

642492:CLOLE RS08340
gene id: 642492:CLOLE_RS08340
uniprot id: F2JKV8
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS06435
gene id: 642492:CLOLE_RS06435
uniprot id: F2JGL7
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS11335
gene id: 642492:CLOLE_RS11335
uniprot id: F2JRN7
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS11305
gene id: 642492:CLOLE_RS11305
uniprot id: F2JRN1
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

642492:CLOLE RS02175
gene id: 642492:CLOLE_RS02175
uniprot id: F2JKH6
names: Similarity
messages: Belongs to the pirin family.

642492:CLOLE RS10560
gene id: 642492:CLOLE_RS10560
uniprot id: F2JQE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

642492:CLOLE RS11980
gene id: 642492:CLOLE_RS11980
uniprot id: F2JSW7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

642492:CLOLE RS14290
gene id: 642492:CLOLE_RS14290
uniprot id: F2JL20
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

642492:CLOLE RS16620
gene id: 642492:CLOLE_RS16620
uniprot id: F2JR37
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

642492:CLOLE RS08350
gene id: 642492:CLOLE_RS08350
uniprot id: F2JLH2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

642492:CLOLE RS13370
gene id: 642492:CLOLE_RS13370
uniprot id: F2JJ73
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS22105
gene id: 642492:CLOLE_RS22105
uniprot id: F2JT59
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

642492:CLOLE RS10570
gene id: 642492:CLOLE_RS10570
uniprot id: F2JQE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

642492:CLOLE RS14845
gene id: 642492:CLOLE_RS14845
uniprot id: F2JMM2
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

642492:CLOLE RS17280
gene id: 642492:CLOLE_RS17280
uniprot id: F2JRU6
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS18905
gene id: 642492:CLOLE_RS18905
uniprot id: F2JII1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS07520
gene id: 642492:CLOLE_RS07520
uniprot id: F2JJ33
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

642492:CLOLE RS06590
gene id: 642492:CLOLE_RS06590
uniprot id: F2JHA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

642492:CLOLE RS18470
gene id: 642492:CLOLE_RS18470
uniprot id: F2JH26
names: Similarity
messages: Belongs to the LacAB/RpiB family.

642492:CLOLE RS12490
gene id: 642492:CLOLE_RS12490
uniprot id: F2JGU8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

642492:CLOLE RS05270
gene id: 642492:CLOLE_RS05270
uniprot id: F2JRE9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

642492:CLOLE RS10790
gene id: 642492:CLOLE_RS10790
uniprot id: F2JQZ5
names: Similarity
messages: Belongs to the UPF0297 family.

642492:CLOLE RS06410
gene id: 642492:CLOLE_RS06410
uniprot id: F2JGL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS06660
gene id: 642492:CLOLE_RS06660
uniprot id: F2JHC1
names: Similarity
messages: Belongs to the UPF0473 family.

642492:CLOLE RS11700
gene id: 642492:CLOLE_RS11700
uniprot id: F2JS95
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

642492:CLOLE RS12880
gene id: 642492:CLOLE_RS12880
uniprot id: F2JHM7
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

642492:CLOLE RS14745
gene id: 642492:CLOLE_RS14745
uniprot id: F2JMK2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

642492:CLOLE RS02870
gene id: 642492:CLOLE_RS02870
uniprot id: F2JM52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS02450
gene id: 642492:CLOLE_RS02450
uniprot id: F2JKN0
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

642492:CLOLE RS01970
gene id: 642492:CLOLE_RS01970
uniprot id: F2JJQ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

642492:CLOLE RS17775
gene id: 642492:CLOLE_RS17775
uniprot id: F2JT04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

642492:CLOLE RS11025
gene id: 642492:CLOLE_RS11025
uniprot id: F2JRH8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

642492:CLOLE RS19850
gene id: 642492:CLOLE_RS19850
uniprot id: F2JKC1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

642492:CLOLE RS00190
gene id: 642492:CLOLE_RS00190
uniprot id: F2JSK8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

642492:CLOLE RS15785
gene id: 642492:CLOLE_RS15785
uniprot id: F2JPB5
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS00500
gene id: 642492:CLOLE_RS00500
uniprot id: F2JGD5
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS08595
gene id: 642492:CLOLE_RS08595
uniprot id: F2JLM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
messages: Cytoplasm

642492:CLOLE RS10450
gene id: 642492:CLOLE_RS10450
uniprot id: F2JQC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

642492:CLOLE RS19970
gene id: 642492:CLOLE_RS19970
uniprot id: F2JKE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS02340
gene id: 642492:CLOLE_RS02340
uniprot id: F2JKK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS06870
gene id: 642492:CLOLE_RS06870
uniprot id: F2JI32
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

642492:CLOLE RS17230
gene id: 642492:CLOLE_RS17230
uniprot id: F2JRT7
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS12005
gene id: 642492:CLOLE_RS12005
uniprot id: F2JSX2
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

642492:CLOLE RS04815
gene id: 642492:CLOLE_RS04815
uniprot id: F2JQR3
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

642492:CLOLE RS05535
gene id: 642492:CLOLE_RS05535
uniprot id: F2JRY7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

642492:CLOLE RS02670
gene id: 642492:CLOLE_RS02670
uniprot id: F2JLD8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

642492:CLOLE RS01025
gene id: 642492:CLOLE_RS01025
uniprot id: F2JHX3
names: Subcellular Location Annotation
messages: Cytoplasm

642492:CLOLE RS09055
gene id: 642492:CLOLE_RS09055
uniprot id: F2JMI8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

642492:CLOLE RS04055
gene id: 642492:CLOLE_RS04055
uniprot id: F2JPF0
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS08010
gene id: 642492:CLOLE_RS08010
uniprot id: F2JKP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS11490
gene id: 642492:CLOLE_RS11490
uniprot id: F2JS53
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

642492:CLOLE RS13375
gene id: 642492:CLOLE_RS13375
uniprot id: F2JJ74
names: Similarity
messages: Belongs to the peptidase S24 family.

642492:CLOLE RS11780
gene id: 642492:CLOLE_RS11780
uniprot id: F2JSS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

642492:CLOLE RS21935
gene id: 642492:CLOLE_RS21935
uniprot id: F2JGM4
names: Similarity
messages: Belongs to the transposase 11 family.

642492:CLOLE RS02265
gene id: 642492:CLOLE_RS02265
uniprot id: F2JKJ3
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS14225
gene id: 642492:CLOLE_RS14225
uniprot id: F2JL08
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

642492:CLOLE RS20645
gene id: 642492:CLOLE_RS20645
uniprot id: F2JM15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

642492:CLOLE RS14220
gene id: 642492:CLOLE_RS14220
uniprot id: F2JL07
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

642492:CLOLE RS13285
gene id: 642492:CLOLE_RS13285
uniprot id: F2JJ55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS00195
gene id: 642492:CLOLE_RS00195
uniprot id: F2JSK9
names: Function
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.
messages: Transcriptional repressor of xylose-utilizing enzymes.

642492:CLOLE RS13295
gene id: 642492:CLOLE_RS13295
uniprot id: F2JJ57
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS00590
gene id: 642492:CLOLE_RS00590
uniprot id: F2JH38
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

642492:CLOLE RS10660
gene id: 642492:CLOLE_RS10660
uniprot id: F2JQX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

642492:CLOLE RS11485
gene id: 642492:CLOLE_RS11485
uniprot id: F2JS52
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

642492:CLOLE RS03680
gene id: 642492:CLOLE_RS03680
uniprot id: F2JNS2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS21330
gene id: 642492:CLOLE_RS21330
uniprot id: F2JNN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS14915
gene id: 642492:CLOLE_RS14915
uniprot id: F2JMN6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

642492:CLOLE RS10215
gene id: 642492:CLOLE_RS10215
uniprot id: F2JPS9
names: Similarity
messages: Belongs to the hemerythrin family.

642492:CLOLE RS15650
gene id: 642492:CLOLE_RS15650
uniprot id: F2JP87
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

642492:CLOLE RS00295
gene id: 642492:CLOLE_RS00295
uniprot id: F2JGB2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

642492:CLOLE RS05650
gene id: 642492:CLOLE_RS05650
uniprot id: F2JS11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

642492:CLOLE RS01275
gene id: 642492:CLOLE_RS01275
uniprot id: F2JI18
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

642492:CLOLE RS07915
gene id: 642492:CLOLE_RS07915
uniprot id: F2JJZ4
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

642492:CLOLE RS19955
gene id: 642492:CLOLE_RS19955
uniprot id: F2JKE4
names: Similarity
messages: Belongs to the glycosyl hydrolase 16 family.

642492:CLOLE RS14920
gene id: 642492:CLOLE_RS14920
uniprot id: F2JMN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

642492:CLOLE RS13520
gene id: 642492:CLOLE_RS13520
uniprot id: F2JJA3
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

642492:CLOLE RS20450
gene id: 642492:CLOLE_RS20450
uniprot id: F2JLX8
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

642492:CLOLE RS05915
gene id: 642492:CLOLE_RS05915
uniprot id: F2JSN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PstS family.
messages: Cell membrane
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

642492:CLOLE RS02965
gene id: 642492:CLOLE_RS02965
uniprot id: F2JM70
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

642492:CLOLE RS13055
gene id: 642492:CLOLE_RS13055
uniprot id: F2JID5
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

642492:CLOLE RS18105
gene id: 642492:CLOLE_RS18105
uniprot id: F2JT70
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

642492:CLOLE RS18380
gene id: 642492:CLOLE_RS18380
uniprot id: F2JH06
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS10525
gene id: 642492:CLOLE_RS10525
uniprot id: F2JQD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

642492:CLOLE RS08520
gene id: 642492:CLOLE_RS08520
uniprot id: F2JLK6
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS12280
gene id: 642492:CLOLE_RS12280
uniprot id: F2JGQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliR/MopE/SpaR family.
messages: Membrane

642492:CLOLE RS17910
gene id: 642492:CLOLE_RS17910
uniprot id: F2JT31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

642492:CLOLE RS20315
gene id: 642492:CLOLE_RS20315
uniprot id: F2JL86
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS18205
gene id: 642492:CLOLE_RS18205
uniprot id: F2JGX0
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS07885
gene id: 642492:CLOLE_RS07885
uniprot id: F2JJY8
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

642492:CLOLE RS01465
gene id: 642492:CLOLE_RS01465
uniprot id: F2JIS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS04645
gene id: 642492:CLOLE_RS04645
uniprot id: F2JQ78
names: Cofactor
names: Similarity
messages: Belongs to the ApbE family.
messages: Magnesium. Can also use manganese.

642492:CLOLE RS19985
gene id: 642492:CLOLE_RS19985
uniprot id: F2JKF0
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS21385
gene id: 642492:CLOLE_RS21385
uniprot id: F2JNP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

642492:CLOLE RS15645
gene id: 642492:CLOLE_RS15645
uniprot id: F2JP86
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

642492:CLOLE RS12120
gene id: 642492:CLOLE_RS12120
uniprot id: F2JSZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

642492:CLOLE RS20875
gene id: 642492:CLOLE_RS20875
uniprot id: F2JMS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

642492:CLOLE RS20270
gene id: 642492:CLOLE_RS20270
uniprot id: F2JL77
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS20495
gene id: 642492:CLOLE_RS20495
uniprot id: F2JLY7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial microcompartment
messages: Belongs to the EutC family.
messages: Binds between the large and small subunits.
messages: Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.
messages: The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.

642492:CLOLE RS10435
gene id: 642492:CLOLE_RS10435
uniprot id: F2JQC1
names: Similarity
names: Subunit
messages: Belongs to the UPF0210 family.
messages: Homodimer.

642492:CLOLE RS17440
gene id: 642492:CLOLE_RS17440
uniprot id: F2JSB8
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

642492:CLOLE RS17570
gene id: 642492:CLOLE_RS17570
uniprot id: F2JSE4
names: Similarity
messages: Belongs to the CdaR family.

642492:CLOLE RS16050
gene id: 642492:CLOLE_RS16050
uniprot id: F2JPX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

642492:CLOLE RS12310
gene id: 642492:CLOLE_RS12310
uniprot id: F2JGR1
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Membrane

642492:CLOLE RS01175
gene id: 642492:CLOLE_RS01175
uniprot id: F2JI00
names: Similarity
messages: Belongs to the ABC transporter superfamily.

642492:CLOLE RS15250
gene id: 642492:CLOLE_RS15250
uniprot id: F2JNG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

642492:CLOLE RS01870
gene id: 642492:CLOLE_RS01870
uniprot id: F2JJN6
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

642492:CLOLE RS06475
gene id: 642492:CLOLE_RS06475
uniprot id: F2JGM5
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: In the native structure, TdcB is in a dimeric form, whereas in the TdcB-AMP complex, it exists in a tetrameric form (dimer of dimers).

642492:CLOLE RS03495
gene id: 642492:CLOLE_RS03495
uniprot id: F2JN41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS21265
gene id: 642492:CLOLE_RS21265
uniprot id: F2JNM4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

642492:CLOLE RS16490
gene id: 642492:CLOLE_RS16490
uniprot id: F2JQK8
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS02200
gene id: 642492:CLOLE_RS02200
uniprot id: F2JKI0
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS08170
gene id: 642492:CLOLE_RS08170
uniprot id: F2JKS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

642492:CLOLE RS21335
gene id: 642492:CLOLE_RS21335
uniprot id: F2JNN8
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

642492:CLOLE RS15700
gene id: 642492:CLOLE_RS15700
uniprot id: F2JP97
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS13325
gene id: 642492:CLOLE_RS13325
uniprot id: F2JJ63
names: Similarity
messages: Belongs to the catalase family.

642492:CLOLE RS07065
gene id: 642492:CLOLE_RS07065
uniprot id: F2JI72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

642492:CLOLE RS03515
gene id: 642492:CLOLE_RS03515
uniprot id: F2JN45
names: Similarity
messages: Belongs to the peptidase S66 family.

642492:CLOLE RS17690
gene id: 642492:CLOLE_RS17690
uniprot id: F2JSG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

642492:CLOLE RS14450
gene id: 642492:CLOLE_RS14450
uniprot id: F2JLR6
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

642492:CLOLE RS17805
gene id: 642492:CLOLE_RS17805
uniprot id: F2JT10
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

642492:CLOLE RS12125
gene id: 642492:CLOLE_RS12125
uniprot id: F2JSZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

642492:CLOLE RS05670
gene id: 642492:CLOLE_RS05670
uniprot id: F2JS15
names: Function
names: Similarity
messages: Belongs to the SpoVG family.
messages: Could be involved in septation.

642492:CLOLE RS08385
gene id: 642492:CLOLE_RS08385
uniprot id: F2JLH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

642492:CLOLE RS17765
gene id: 642492:CLOLE_RS17765
uniprot id: F2JT02
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

642492:CLOLE RS17875
gene id: 642492:CLOLE_RS17875
uniprot id: F2JT24
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

642492:CLOLE RS10600
gene id: 642492:CLOLE_RS10600
uniprot id: F2JQF4
names: Caution
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS17300
gene id: 642492:CLOLE_RS17300
uniprot id: F2JRV0
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS19695
gene id: 642492:CLOLE_RS19695
uniprot id: F2JK92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.
messages: Membrane

642492:CLOLE RS17560
gene id: 642492:CLOLE_RS17560
uniprot id: F2JSE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation.

642492:CLOLE RS09155
gene id: 642492:CLOLE_RS09155
uniprot id: F2JN72
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS17665
gene id: 642492:CLOLE_RS17665
uniprot id: F2JSG3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

642492:CLOLE RS14735
gene id: 642492:CLOLE_RS14735
uniprot id: F2JMK0
names: Function
names: Similarity
messages: Belongs to the alpha/beta-type SASP family.
messages: SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.

642492:CLOLE RS09960
gene id: 642492:CLOLE_RS09960
uniprot id: F2JPM6
names: Function
messages: Abolishes the inhibitory effect of tetracyclin on protein synthesis by a non-covalent modification of the ribosomes.

642492:CLOLE RS16975
gene id: 642492:CLOLE_RS16975
uniprot id: F2JR91
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

642492:CLOLE RS10665
gene id: 642492:CLOLE_RS10665
uniprot id: F2JQX1
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

642492:CLOLE RS08145
gene id: 642492:CLOLE_RS08145
uniprot id: F2JKR9
names: Similarity
messages: Belongs to the Nudix hydrolase family.

642492:CLOLE RS11220
gene id: 642492:CLOLE_RS11220
uniprot id: F2JRL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

642492:CLOLE RS14380
gene id: 642492:CLOLE_RS14380
uniprot id: F2JLQ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MetA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

642492:CLOLE RS06690
gene id: 642492:CLOLE_RS06690
uniprot id: F2JHC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS19335
gene id: 642492:CLOLE_RS19335
uniprot id: F2JJE2
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

642492:CLOLE RS19705
gene id: 642492:CLOLE_RS19705
uniprot id: F2JK94
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

642492:CLOLE RS18195
gene id: 642492:CLOLE_RS18195
uniprot id: F2JGW8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

642492:CLOLE RS09550
gene id: 642492:CLOLE_RS09550
uniprot id: F2JNZ5
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS01490
gene id: 642492:CLOLE_RS01490
uniprot id: F2JIT3
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

642492:CLOLE RS12715
gene id: 642492:CLOLE_RS12715
uniprot id: F2JHJ6
names: Similarity
messages: Belongs to the hemerythrin family.

642492:CLOLE RS21205
gene id: 642492:CLOLE_RS21205
uniprot id: F2JMY6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

642492:CLOLE RS14795
gene id: 642492:CLOLE_RS14795
uniprot id: F2JML3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
messages: Cytoplasm

642492:CLOLE RS17610
gene id: 642492:CLOLE_RS17610
uniprot id: F2JSF2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

642492:CLOLE RS11565
gene id: 642492:CLOLE_RS11565
uniprot id: F2JS68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS02075
gene id: 642492:CLOLE_RS02075
uniprot id: F2JJS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

642492:CLOLE RS03475
gene id: 642492:CLOLE_RS03475
uniprot id: F2JN37
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS17735
gene id: 642492:CLOLE_RS17735
uniprot id: F2JSH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

642492:CLOLE RS13640
gene id: 642492:CLOLE_RS13640
uniprot id: F2JJC6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

642492:CLOLE RS17125
gene id: 642492:CLOLE_RS17125
uniprot id: F2JRR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

642492:CLOLE RS11685
gene id: 642492:CLOLE_RS11685
uniprot id: F2JS92
names: Similarity
messages: Belongs to the DprA/Smf family.

642492:CLOLE RS17155
gene id: 642492:CLOLE_RS17155
uniprot id: F2JRS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

642492:CLOLE RS05925
gene id: 642492:CLOLE_RS05925
uniprot id: F2JSN4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

642492:CLOLE RS08905
gene id: 642492:CLOLE_RS08905
uniprot id: F2JMF6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

642492:CLOLE RS01020
gene id: 642492:CLOLE_RS01020
uniprot id: F2JHX2
names: Subcellular Location Annotation
messages: Cytoplasm

642492:CLOLE RS02045
gene id: 642492:CLOLE_RS02045
uniprot id: F2JJS0
names: Similarity
messages: Belongs to the CapA family.

642492:CLOLE RS17415
gene id: 642492:CLOLE_RS17415
uniprot id: F2JSB5
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

642492:CLOLE RS09985
gene id: 642492:CLOLE_RS09985
uniprot id: F2JPN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

642492:CLOLE RS17740
gene id: 642492:CLOLE_RS17740
uniprot id: F2JSH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

642492:CLOLE RS08975
gene id: 642492:CLOLE_RS08975
uniprot id: F2JMH2
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.

642492:CLOLE RS14255
gene id: 642492:CLOLE_RS14255
uniprot id: F2JL13
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homodimer.

642492:CLOLE RS06780
gene id: 642492:CLOLE_RS06780
uniprot id: F2JHE6
names: Similarity
messages: Belongs to the antibiotic N-acetyltransferase family.

642492:CLOLE RS19010
gene id: 642492:CLOLE_RS19010
uniprot id: F2JIK2
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

642492:CLOLE RS02805
gene id: 642492:CLOLE_RS02805
uniprot id: F2JLG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS18260
gene id: 642492:CLOLE_RS18260
uniprot id: F2JGY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase D family. Cardiolipin synthase subfamily.
messages: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS17450
gene id: 642492:CLOLE_RS17450
uniprot id: F2JSC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS14635
gene id: 642492:CLOLE_RS14635
uniprot id: F2JLV6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

642492:CLOLE RS05445
gene id: 642492:CLOLE_RS05445
uniprot id: F2JRX8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS15110
gene id: 642492:CLOLE_RS15110
uniprot id: F2JNE1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.

642492:CLOLE RS18980
gene id: 642492:CLOLE_RS18980
uniprot id: F2JIJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS01040
gene id: 642492:CLOLE_RS01040
uniprot id: F2JHX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

642492:CLOLE RS17405
gene id: 642492:CLOLE_RS17405
uniprot id: F2JSB3
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

642492:CLOLE RS16775
gene id: 642492:CLOLE_RS16775
uniprot id: F2JR51
names: Similarity
messages: Belongs to the ycf81 family.

642492:CLOLE RS05685
gene id: 642492:CLOLE_RS05685
uniprot id: F2JS18
names: Similarity
messages: Belongs to the glycosyl hydrolase 26 family.

642492:CLOLE RS06195
gene id: 642492:CLOLE_RS06195
uniprot id: F2JGG8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

642492:CLOLE RS17750
gene id: 642492:CLOLE_RS17750
uniprot id: F2JSI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

642492:CLOLE RS12165
gene id: 642492:CLOLE_RS12165
uniprot id: F2JGN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

642492:CLOLE RS16865
gene id: 642492:CLOLE_RS16865
uniprot id: F2JR69
names: Cofactor
messages: Binds 1 zinc ion per subunit.

642492:CLOLE RS11600
gene id: 642492:CLOLE_RS11600
uniprot id: F2JS75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

642492:CLOLE RS09020
gene id: 642492:CLOLE_RS09020
uniprot id: F2JMI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

642492:CLOLE RS18175
gene id: 642492:CLOLE_RS18175
uniprot id: F2JGW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

642492:CLOLE RS17400
gene id: 642492:CLOLE_RS17400
uniprot id: F2JSB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

642492:CLOLE RS16825
gene id: 642492:CLOLE_RS16825
uniprot id: F2JR61
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS08590
gene id: 642492:CLOLE_RS08590
uniprot id: F2JLM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

642492:CLOLE RS16165
gene id: 642492:CLOLE_RS16165
uniprot id: F2JPZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

642492:CLOLE RS17535
gene id: 642492:CLOLE_RS17535
uniprot id: F2JSD7
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS13000
gene id: 642492:CLOLE_RS13000
uniprot id: F2JIC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS05850
gene id: 642492:CLOLE_RS05850
uniprot id: F2JSM1
names: Similarity
messages: Belongs to the peptidase S16 family.

642492:CLOLE RS18960
gene id: 642492:CLOLE_RS18960
uniprot id: F2JIJ2
names: Similarity
messages: Belongs to the diacylglycerol/lipid kinase family.

642492:CLOLE RS10795
gene id: 642492:CLOLE_RS10795
uniprot id: F2JQZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

642492:CLOLE RS07430
gene id: 642492:CLOLE_RS07430
uniprot id: F2JJ14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS03020
gene id: 642492:CLOLE_RS03020
uniprot id: F2JM80
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 51 family.
messages: Homohexamer; trimer of dimers.

642492:CLOLE RS11300
gene id: 642492:CLOLE_RS11300
uniprot id: F2JRN0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

642492:CLOLE RS08305
gene id: 642492:CLOLE_RS08305
uniprot id: F2JKV1
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

642492:CLOLE RS15550
gene id: 642492:CLOLE_RS15550
uniprot id: F2JP66
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS00705
gene id: 642492:CLOLE_RS00705
uniprot id: F2JH50
names: Similarity
messages: Belongs to the peptidase M13 family.

642492:CLOLE RS09665
gene id: 642492:CLOLE_RS09665
uniprot id: F2JP19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS12405
gene id: 642492:CLOLE_RS12405
uniprot id: F2JGT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

642492:CLOLE RS16900
gene id: 642492:CLOLE_RS16900
uniprot id: F2JR76
names: Similarity
messages: Belongs to the glycosyl hydrolase.

642492:CLOLE RS10345
gene id: 642492:CLOLE_RS10345
uniprot id: F2JQA2
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS15675
gene id: 642492:CLOLE_RS15675
uniprot id: F2JP92
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS13305
gene id: 642492:CLOLE_RS13305
uniprot id: F2JJ59
names: Similarity
messages: Belongs to the RutC family.

642492:CLOLE RS11315
gene id: 642492:CLOLE_RS11315
uniprot id: F2JRN3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

642492:CLOLE RS15095
gene id: 642492:CLOLE_RS15095
uniprot id: F2JMR3
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

642492:CLOLE RS12495
gene id: 642492:CLOLE_RS12495
uniprot id: F2JGU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

642492:CLOLE RS02880
gene id: 642492:CLOLE_RS02880
uniprot id: F2JM54
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

642492:CLOLE RS00320
gene id: 642492:CLOLE_RS00320
uniprot id: F2JGB7
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

642492:CLOLE RS20895
gene id: 642492:CLOLE_RS20895
uniprot id: F2JMS7
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

642492:CLOLE RS05225
gene id: 642492:CLOLE_RS05225
uniprot id: F2JRE0
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

642492:CLOLE RS11705
gene id: 642492:CLOLE_RS11705
uniprot id: F2JS96
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

642492:CLOLE RS20235
gene id: 642492:CLOLE_RS20235
uniprot id: F2JL70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS02610
gene id: 642492:CLOLE_RS02610
uniprot id: F2JLC7
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the FGGY kinase family.
messages: Homotetramer and homodimer (in equilibrium).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

642492:CLOLE RS17335
gene id: 642492:CLOLE_RS17335
uniprot id: F2JRV7
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

642492:CLOLE RS19245
gene id: 642492:CLOLE_RS19245
uniprot id: F2JIP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS21280
gene id: 642492:CLOLE_RS21280
uniprot id: F2JNM7
names: Similarity
messages: Belongs to the glutamate synthase family.

642492:CLOLE RS18215
gene id: 642492:CLOLE_RS18215
uniprot id: F2JGX2
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

642492:CLOLE RS15285
gene id: 642492:CLOLE_RS15285
uniprot id: F2JNH5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

642492:CLOLE RS10585
gene id: 642492:CLOLE_RS10585
uniprot id: F2JQF1
names: Function
names: Similarity
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.

642492:CLOLE RS03295
gene id: 642492:CLOLE_RS03295
uniprot id: F2JN01
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

642492:CLOLE RS19110
gene id: 642492:CLOLE_RS19110
uniprot id: F2JIM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS10590
gene id: 642492:CLOLE_RS10590
uniprot id: F2JQF2
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

642492:CLOLE RS18475
gene id: 642492:CLOLE_RS18475
uniprot id: F2JH27
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

642492:CLOLE RS04075
gene id: 642492:CLOLE_RS04075
uniprot id: F2JPF4
names: Similarity
messages: Belongs to the class-I fumarase family.

642492:CLOLE RS05635
gene id: 642492:CLOLE_RS05635
uniprot id: F2JS08
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

642492:CLOLE RS05215
gene id: 642492:CLOLE_RS05215
uniprot id: F2JRD8
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS12875
gene id: 642492:CLOLE_RS12875
uniprot id: F2JHM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

642492:CLOLE RS06285
gene id: 642492:CLOLE_RS06285
uniprot id: F2JGI7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

642492:CLOLE RS08635
gene id: 642492:CLOLE_RS08635
uniprot id: F2JLM9
names: Similarity
messages: Belongs to the peptidase S8 family.

642492:CLOLE RS12980
gene id: 642492:CLOLE_RS12980
uniprot id: F2JIC0
names: Similarity
messages: Belongs to the pyruvate kinase family.
messages: In the C-terminal section; belongs to the PEP-utilizing enzyme family.

642492:CLOLE RS07460
gene id: 642492:CLOLE_RS07460
uniprot id: F2JJ20
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

642492:CLOLE RS17810
gene id: 642492:CLOLE_RS17810
uniprot id: F2JT11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

642492:CLOLE RS21380
gene id: 642492:CLOLE_RS21380
uniprot id: F2JNP8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

642492:CLOLE RS03830
gene id: 642492:CLOLE_RS03830
uniprot id: F2JNV0
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

642492:CLOLE RS07730
gene id: 642492:CLOLE_RS07730
uniprot id: F2JJV5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

642492:CLOLE RS23860
gene id: 642492:CLOLE_RS23860
uniprot id: F2JHR8
names: Similarity
messages: Belongs to the peptidase C40 family.

642492:CLOLE RS02455
gene id: 642492:CLOLE_RS02455
uniprot id: F2JKN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

642492:CLOLE RS03045
gene id: 642492:CLOLE_RS03045
uniprot id: F2JM85
names: Function
names: Similarity
messages: Belongs to the mannonate dehydratase family.
messages: Catalyzes the dehydration of D-mannonate.

642492:CLOLE RS19435
gene id: 642492:CLOLE_RS19435
uniprot id: F2JJG2
names: Similarity
messages: Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.

642492:CLOLE RS09120
gene id: 642492:CLOLE_RS09120
uniprot id: F2JN65
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecU family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation.

642492:CLOLE RS05620
gene id: 642492:CLOLE_RS05620
uniprot id: F2JS05
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.

642492:CLOLE RS20070
gene id: 642492:CLOLE_RS20070
uniprot id: F2JL37
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS07700
gene id: 642492:CLOLE_RS07700
uniprot id: F2JJU9
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

642492:CLOLE RS21255
gene id: 642492:CLOLE_RS21255
uniprot id: F2JNM2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS16200
gene id: 642492:CLOLE_RS16200
uniprot id: F2JQ00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS01555
gene id: 642492:CLOLE_RS01555
uniprot id: F2JIU5
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

642492:CLOLE RS09820
gene id: 642492:CLOLE_RS09820
uniprot id: F2JP49
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

642492:CLOLE RS05265
gene id: 642492:CLOLE_RS05265
uniprot id: F2JRE8
names: Similarity
messages: Belongs to the GerABKA family.

642492:CLOLE RS11725
gene id: 642492:CLOLE_RS11725
uniprot id: F2JSA0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS03340
gene id: 642492:CLOLE_RS03340
uniprot id: F2JN10
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

642492:CLOLE RS17370
gene id: 642492:CLOLE_RS17370
uniprot id: F2JRW4
names: Similarity
messages: Belongs to the CapA family.

642492:CLOLE RS21065
gene id: 642492:CLOLE_RS21065
uniprot id: F2JMV9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

642492:CLOLE RS17795
gene id: 642492:CLOLE_RS17795
uniprot id: F2JT08
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

642492:CLOLE RS21390
gene id: 642492:CLOLE_RS21390
uniprot id: F2JNQ0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS10030
gene id: 642492:CLOLE_RS10030
uniprot id: F2JPP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

642492:CLOLE RS03650
gene id: 642492:CLOLE_RS03650
uniprot id: F2JNR6
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS09060
gene id: 642492:CLOLE_RS09060
uniprot id: F2JMI9
names: Similarity
messages: Belongs to the asp23 family.

642492:CLOLE RS16875
gene id: 642492:CLOLE_RS16875
uniprot id: F2JR71
names: Function
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.
messages: Belongs to the cellobiose 2-epimerase family.
messages: Catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man).

642492:CLOLE RS04710
gene id: 642492:CLOLE_RS04710
uniprot id: F2JQP4
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS03740
gene id: 642492:CLOLE_RS03740
uniprot id: F2JNT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

642492:CLOLE RS14505
gene id: 642492:CLOLE_RS14505
uniprot id: F2JLS8
names: Similarity
messages: Belongs to the UPF0178 family.

642492:CLOLE RS21055
gene id: 642492:CLOLE_RS21055
uniprot id: F2JMV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

642492:CLOLE RS17815
gene id: 642492:CLOLE_RS17815
uniprot id: F2JT12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

642492:CLOLE RS08040
gene id: 642492:CLOLE_RS08040
uniprot id: F2JKP8
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

642492:CLOLE RS18065
gene id: 642492:CLOLE_RS18065
uniprot id: F2JT62
names: Similarity
messages: Belongs to the FlgM family.

642492:CLOLE RS18055
gene id: 642492:CLOLE_RS18055
uniprot id: F2JT60
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

642492:CLOLE RS01325
gene id: 642492:CLOLE_RS01325
uniprot id: F2JI29
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS12195
gene id: 642492:CLOLE_RS12195
uniprot id: F2JGN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

642492:CLOLE RS16420
gene id: 642492:CLOLE_RS16420
uniprot id: F2JQJ4
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

642492:CLOLE RS15665
gene id: 642492:CLOLE_RS15665
uniprot id: F2JP90
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS00025
gene id: 642492:CLOLE_RS00025
uniprot id: F2JSI7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

642492:CLOLE RS10885
gene id: 642492:CLOLE_RS10885
uniprot id: F2JR14
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS17625
gene id: 642492:CLOLE_RS17625
uniprot id: F2JSF5
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

642492:CLOLE RS20690
gene id: 642492:CLOLE_RS20690
uniprot id: F2JM22
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS11975
gene id: 642492:CLOLE_RS11975
uniprot id: F2JSW6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

642492:CLOLE RS13620
gene id: 642492:CLOLE_RS13620
uniprot id: F2JJC2
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

642492:CLOLE RS18370
gene id: 642492:CLOLE_RS18370
uniprot id: F2JH04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

642492:CLOLE RS07825
gene id: 642492:CLOLE_RS07825
uniprot id: F2JJX6
names: Similarity
messages: Belongs to the UPF0597 family.

642492:CLOLE RS00415
gene id: 642492:CLOLE_RS00415
uniprot id: F2JGC4
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS13610
gene id: 642492:CLOLE_RS13610
uniprot id: F2JJC0
names: Similarity
messages: Belongs to the peptidase C59 family.

642492:CLOLE RS02585
gene id: 642492:CLOLE_RS02585
uniprot id: F2JLC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

642492:CLOLE RS00830
gene id: 642492:CLOLE_RS00830
uniprot id: F2JH62
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS05305
gene id: 642492:CLOLE_RS05305
uniprot id: F2JRF6
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS12140
gene id: 642492:CLOLE_RS12140
uniprot id: F2JSZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

642492:CLOLE RS08220
gene id: 642492:CLOLE_RS08220
uniprot id: F2JKT4
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.

642492:CLOLE RS10640
gene id: 642492:CLOLE_RS10640
uniprot id: F2JQW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

642492:CLOLE RS11745
gene id: 642492:CLOLE_RS11745
uniprot id: F2JSA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

642492:CLOLE RS16070
gene id: 642492:CLOLE_RS16070
uniprot id: F2JPX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
messages: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
messages: Cytoplasm
messages: Homodimer.

642492:CLOLE RS18835
gene id: 642492:CLOLE_RS18835
uniprot id: F2JHS7
names: Similarity
messages: Belongs to the WXG100 family.

642492:CLOLE RS21410
gene id: 642492:CLOLE_RS21410
uniprot id: F2JNQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

642492:CLOLE RS17235
gene id: 642492:CLOLE_RS17235
uniprot id: F2JRT8
names: Similarity
messages: Belongs to the YjdM family.

642492:CLOLE RS18355
gene id: 642492:CLOLE_RS18355
uniprot id: F2JH00
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

642492:CLOLE RS10070
gene id: 642492:CLOLE_RS10070
uniprot id: F2JPP7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates zinc uptake. May also transport other divalent cations.
messages: Membrane

642492:CLOLE RS09185
gene id: 642492:CLOLE_RS09185
uniprot id: F2JN78
names: Similarity
messages: Belongs to the thymidine kinase family.

642492:CLOLE RS07500
gene id: 642492:CLOLE_RS07500
uniprot id: F2JJ29
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

642492:CLOLE RS07465
gene id: 642492:CLOLE_RS07465
uniprot id: F2JJ21
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS20255
gene id: 642492:CLOLE_RS20255
uniprot id: F2JL74
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS10770
gene id: 642492:CLOLE_RS10770
uniprot id: F2JQZ1
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

642492:CLOLE RS21140
gene id: 642492:CLOLE_RS21140
uniprot id: F2JMX4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

642492:CLOLE RS12170
gene id: 642492:CLOLE_RS12170
uniprot id: F2JGN3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

642492:CLOLE RS09045
gene id: 642492:CLOLE_RS09045
uniprot id: F2JMI6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

642492:CLOLE RS11665
gene id: 642492:CLOLE_RS11665
uniprot id: F2JS88
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcAL family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS11070
gene id: 642492:CLOLE_RS11070
uniprot id: F2JRI7
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.

642492:CLOLE RS02010
gene id: 642492:CLOLE_RS02010
uniprot id: F2JJR3
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS10445
gene id: 642492:CLOLE_RS10445
uniprot id: F2JQC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

642492:CLOLE RS15160
gene id: 642492:CLOLE_RS15160
uniprot id: F2JNF1
names: Caution
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

642492:CLOLE RS16290
gene id: 642492:CLOLE_RS16290
uniprot id: F2JQG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS08815
gene id: 642492:CLOLE_RS08815
uniprot id: F2JMD8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

642492:CLOLE RS11185
gene id: 642492:CLOLE_RS11185
uniprot id: F2JRK8
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS14055
gene id: 642492:CLOLE_RS14055
uniprot id: F2JKX4
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

642492:CLOLE RS05375
gene id: 642492:CLOLE_RS05375
uniprot id: F2JRH1
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

642492:CLOLE RS12385
gene id: 642492:CLOLE_RS12385
uniprot id: F2JGS6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

642492:CLOLE RS03730
gene id: 642492:CLOLE_RS03730
uniprot id: F2JNT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

642492:CLOLE RS17605
gene id: 642492:CLOLE_RS17605
uniprot id: F2JSF1
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

642492:CLOLE RS07455
gene id: 642492:CLOLE_RS07455
uniprot id: F2JJ19
names: Function
names: Similarity
messages: Belongs to the alpha/beta-type SASP family.
messages: SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.

642492:CLOLE RS02835
gene id: 642492:CLOLE_RS02835
uniprot id: F2JLG9
names: Function
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.
messages: Transcriptional repressor of xylose-utilizing enzymes.

642492:CLOLE RS08425
gene id: 642492:CLOLE_RS08425
uniprot id: F2JLI6
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

642492:CLOLE RS02700
gene id: 642492:CLOLE_RS02700
uniprot id: F2JLE3
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS10400
gene id: 642492:CLOLE_RS10400
uniprot id: F2JQB4
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

642492:CLOLE RS20800
gene id: 642492:CLOLE_RS20800
uniprot id: F2JM43
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

642492:CLOLE RS20475
gene id: 642492:CLOLE_RS20475
uniprot id: F2JLY3
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

642492:CLOLE RS10635
gene id: 642492:CLOLE_RS10635
uniprot id: F2JQW5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

642492:CLOLE RS07025
gene id: 642492:CLOLE_RS07025
uniprot id: F2JI63
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.

642492:CLOLE RS12265
gene id: 642492:CLOLE_RS12265
uniprot id: F2JGQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Cell membrane
messages: Membrane
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

642492:CLOLE RS07540
gene id: 642492:CLOLE_RS07540
uniprot id: F2JJ37
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS17635
gene id: 642492:CLOLE_RS17635
uniprot id: F2JSF7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

642492:CLOLE RS06065
gene id: 642492:CLOLE_RS06065
uniprot id: F2JSR3
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

642492:CLOLE RS06605
gene id: 642492:CLOLE_RS06605
uniprot id: F2JHA8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

642492:CLOLE RS23775
gene id: 642492:CLOLE_RS23775
uniprot id: F2JNT0
names: Similarity
messages: Belongs to the glycosyl hydrolase 53 family.

642492:CLOLE RS08535
gene id: 642492:CLOLE_RS08535
uniprot id: F2JLK9
names: Similarity
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.

642492:CLOLE RS17245
gene id: 642492:CLOLE_RS17245
uniprot id: F2JRU0
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

642492:CLOLE RS08910
gene id: 642492:CLOLE_RS08910
uniprot id: F2JMF7
names: Similarity
messages: Belongs to the TlyA family.

642492:CLOLE RS11675
gene id: 642492:CLOLE_RS11675
uniprot id: F2JS90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CodY family.
messages: Cytoplasm
messages: DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability. During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion.

642492:CLOLE RS05290
gene id: 642492:CLOLE_RS05290
uniprot id: F2JRF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

642492:CLOLE RS20360
gene id: 642492:CLOLE_RS20360
uniprot id: F2JL94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS18350
gene id: 642492:CLOLE_RS18350
uniprot id: F2JGZ9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

642492:CLOLE RS20675
gene id: 642492:CLOLE_RS20675
uniprot id: F2JM19
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS19745
gene id: 642492:CLOLE_RS19745
uniprot id: F2JKA2
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS08025
gene id: 642492:CLOLE_RS08025
uniprot id: F2JKP5
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

642492:CLOLE RS16370
gene id: 642492:CLOLE_RS16370
uniprot id: F2JQI4
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS12335
gene id: 642492:CLOLE_RS12335
uniprot id: F2JGR6
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

642492:CLOLE RS07015
gene id: 642492:CLOLE_RS07015
uniprot id: F2JI61
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

642492:CLOLE RS16315
gene id: 642492:CLOLE_RS16315
uniprot id: F2JQH3
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS10800
gene id: 642492:CLOLE_RS10800
uniprot id: F2JQZ7
names: Similarity
messages: Belongs to the UPF0473 family.

642492:CLOLE RS14525
gene id: 642492:CLOLE_RS14525
uniprot id: F2JLT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-ACP thioesterase family.
messages: chloroplast

642492:CLOLE RS00220
gene id: 642492:CLOLE_RS00220
uniprot id: F2JG99
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

642492:CLOLE RS15830
gene id: 642492:CLOLE_RS15830
uniprot id: F2JPC4
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS20950
gene id: 642492:CLOLE_RS20950
uniprot id: F2JMT8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

642492:CLOLE RS19465
gene id: 642492:CLOLE_RS19465
uniprot id: F2JJG8
names: Subcellular Location Annotation
messages: Membrane

642492:CLOLE RS13005
gene id: 642492:CLOLE_RS13005
uniprot id: F2JIC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS07160
gene id: 642492:CLOLE_RS07160
uniprot id: F2JI91
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

642492:CLOLE RS21150
gene id: 642492:CLOLE_RS21150
uniprot id: F2JMX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

642492:CLOLE RS05845
gene id: 642492:CLOLE_RS05845
uniprot id: F2JSM0
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

642492:CLOLE RS13420
gene id: 642492:CLOLE_RS13420
uniprot id: F2JJ83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

642492:CLOLE RS04885
gene id: 642492:CLOLE_RS04885
uniprot id: F2JQT2
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

642492:CLOLE RS14120
gene id: 642492:CLOLE_RS14120
uniprot id: F2JKY7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.