640132:SROT RS05690
gene id: 640132:SROT_RS05690
uniprot id: D6ZF83
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

640132:SROT RS12395
gene id: 640132:SROT_RS12395
uniprot id: D6ZBG6
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

640132:SROT RS15380
gene id: 640132:SROT_RS15380
uniprot id: D6ZEM2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

640132:SROT RS05455
gene id: 640132:SROT_RS05455
uniprot id: D6ZF37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

640132:SROT RS09120
gene id: 640132:SROT_RS09120
uniprot id: D6Z8K1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

640132:SROT RS04780
gene id: 640132:SROT_RS04780
uniprot id: D6ZEP9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

640132:SROT RS12840
gene id: 640132:SROT_RS12840
uniprot id: D6ZC35
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

640132:SROT RS13345
gene id: 640132:SROT_RS13345
uniprot id: D6ZCD1
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

640132:SROT RS15490
gene id: 640132:SROT_RS15490
uniprot id: D6ZDB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

640132:SROT RS04940
gene id: 640132:SROT_RS04940
uniprot id: D6ZET1
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

640132:SROT RS12060
gene id: 640132:SROT_RS12060
uniprot id: D6ZAW9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

640132:SROT RS10765
gene id: 640132:SROT_RS10765
uniprot id: D6Z9T1
names: Similarity
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.

640132:SROT RS17035
gene id: 640132:SROT_RS17035
uniprot id: D6ZFM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Mmr subfamily.
messages: Cell membrane
messages: Membrane

640132:SROT RS00085
gene id: 640132:SROT_RS00085
uniprot id: D6Z9I1
names: Similarity
messages: Belongs to the thioredoxin family.

640132:SROT RS02590
gene id: 640132:SROT_RS02590
uniprot id: D6ZC21
names: Similarity
messages: Belongs to the cysteine dioxygenase family.

640132:SROT RS15155
gene id: 640132:SROT_RS15155
uniprot id: D6ZEH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

640132:SROT RS12235
gene id: 640132:SROT_RS12235
uniprot id: D6ZBD9
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

640132:SROT RS07850
gene id: 640132:SROT_RS07850
uniprot id: D6Z7U8
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

640132:SROT RS12610
gene id: 640132:SROT_RS12610
uniprot id: D6ZBK6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

640132:SROT RS11485
gene id: 640132:SROT_RS11485
uniprot id: D6ZAK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

640132:SROT RS06110
gene id: 640132:SROT_RS06110
uniprot id: D6ZFG9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
messages: Monomer.

640132:SROT RS02030
gene id: 640132:SROT_RS02030
uniprot id: D6ZBR2
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

640132:SROT RS01845
gene id: 640132:SROT_RS01845
uniprot id: D6ZB95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

640132:SROT RS00810
gene id: 640132:SROT_RS00810
uniprot id: D6ZAA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

640132:SROT RS10255
gene id: 640132:SROT_RS10255
uniprot id: D6Z980
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

640132:SROT RS01855
gene id: 640132:SROT_RS01855
uniprot id: D6ZB97
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS09610
gene id: 640132:SROT_RS09610
uniprot id: D6Z8V1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

640132:SROT RS05020
gene id: 640132:SROT_RS05020
uniprot id: D6ZEU7
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS14170
gene id: 640132:SROT_RS14170
uniprot id: D6ZD68
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Could possibly oxidize fatty acids using specific components.

640132:SROT RS04990
gene id: 640132:SROT_RS04990
uniprot id: D6ZEU1
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

640132:SROT RS11575
gene id: 640132:SROT_RS11575
uniprot id: D6ZAM8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

640132:SROT RS01225
gene id: 640132:SROT_RS01225
uniprot id: D6ZAI5
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS08980
gene id: 640132:SROT_RS08980
uniprot id: D6Z8H7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

640132:SROT RS10690
gene id: 640132:SROT_RS10690
uniprot id: D6Z9F8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: May be specifically involved in the processing, transport, and/or maturation of the MADH beta-subunit.
messages: Membrane

640132:SROT RS13440
gene id: 640132:SROT_RS13440
uniprot id: D6ZCF0
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

640132:SROT RS01520
gene id: 640132:SROT_RS01520
uniprot id: D6ZB28
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

640132:SROT RS08715
gene id: 640132:SROT_RS08715
uniprot id: D6Z8C4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

640132:SROT RS07905
gene id: 640132:SROT_RS07905
uniprot id: D6Z7W0
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

640132:SROT RS11095
gene id: 640132:SROT_RS11095
uniprot id: D6Z9Z7
names: Similarity
messages: Belongs to the thymidylate kinase family.

640132:SROT RS12075
gene id: 640132:SROT_RS12075
uniprot id: D6ZAX2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

640132:SROT RS08490
gene id: 640132:SROT_RS08490
uniprot id: D6Z877
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell inner membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

640132:SROT RS08175
gene id: 640132:SROT_RS08175
uniprot id: D6Z813
names: Function
names: Similarity
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family. MetZ subfamily.
messages: Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide.
messages: Homotetramer.

640132:SROT RS10715
gene id: 640132:SROT_RS10715
uniprot id: D6Z9G2
names: Similarity
messages: Belongs to the peptidase S16 family.

640132:SROT RS14065
gene id: 640132:SROT_RS14065
uniprot id: D6ZD51
names: Similarity
messages: Belongs to the WXG100 family.

640132:SROT RS00850
gene id: 640132:SROT_RS00850
uniprot id: D6ZAB0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

640132:SROT RS11125
gene id: 640132:SROT_RS11125
uniprot id: D6ZA03
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

640132:SROT RS03785
gene id: 640132:SROT_RS03785
uniprot id: D6ZDG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EccD/Snm4 family.
messages: Membrane

640132:SROT RS09350
gene id: 640132:SROT_RS09350
uniprot id: D6Z8P9
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

640132:SROT RS03595
gene id: 640132:SROT_RS03595
uniprot id: D6ZDC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

640132:SROT RS04125
gene id: 640132:SROT_RS04125
uniprot id: D6ZE16
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS08790
gene id: 640132:SROT_RS08790
uniprot id: D6Z8D9
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

640132:SROT RS15250
gene id: 640132:SROT_RS15250
uniprot id: D6ZEJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. MshD subfamily.
messages: Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
messages: Monomer.

640132:SROT RS11190
gene id: 640132:SROT_RS11190
uniprot id: D6ZA16
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

640132:SROT RS10085
gene id: 640132:SROT_RS10085
uniprot id: D6Z946
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

640132:SROT RS11320
gene id: 640132:SROT_RS11320
uniprot id: D6ZA42
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.

640132:SROT RS08930
gene id: 640132:SROT_RS08930
uniprot id: D6Z8G7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the malate synthase family. GlcB subfamily.
messages: Cytoplasm
messages: Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

640132:SROT RS09940
gene id: 640132:SROT_RS09940
uniprot id: D6Z916
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

640132:SROT RS02995
gene id: 640132:SROT_RS02995
uniprot id: D6ZCN3
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS14230
gene id: 640132:SROT_RS14230
uniprot id: D6ZDL0
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS13645
gene id: 640132:SROT_RS13645
uniprot id: D6ZCX3
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

640132:SROT RS11690
gene id: 640132:SROT_RS11690
uniprot id: D6ZAQ1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS02275
gene id: 640132:SROT_RS02275
uniprot id: D6ZBW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

640132:SROT RS02280
gene id: 640132:SROT_RS02280
uniprot id: D6ZBW5
names: Similarity
messages: Belongs to the TrpC family.

640132:SROT RS08740
gene id: 640132:SROT_RS08740
uniprot id: D6Z8C9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

640132:SROT RS04970
gene id: 640132:SROT_RS04970
uniprot id: D6ZET7
names: Function
names: Similarity
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.

640132:SROT RS02425
gene id: 640132:SROT_RS02425
uniprot id: D6ZBZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

640132:SROT RS05465
gene id: 640132:SROT_RS05465
uniprot id: D6ZF39
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

640132:SROT RS09590
gene id: 640132:SROT_RS09590
uniprot id: D6Z8U7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS10955
gene id: 640132:SROT_RS10955
uniprot id: D6Z9W9
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS09245
gene id: 640132:SROT_RS09245
uniprot id: D6Z8M7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

640132:SROT RS07300
gene id: 640132:SROT_RS07300
uniprot id: D6Z7J2
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

640132:SROT RS09465
gene id: 640132:SROT_RS09465
uniprot id: D6Z8S2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

640132:SROT RS05000
gene id: 640132:SROT_RS05000
uniprot id: D6ZEU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

640132:SROT RS09935
gene id: 640132:SROT_RS09935
uniprot id: D6Z915
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

640132:SROT RS09040
gene id: 640132:SROT_RS09040
uniprot id: D6Z8I9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS03880
gene id: 640132:SROT_RS03880
uniprot id: D6ZDI2
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase.

640132:SROT RS09995
gene id: 640132:SROT_RS09995
uniprot id: D6Z927
names: Similarity
messages: Belongs to the ribF family.

640132:SROT RS13055
gene id: 640132:SROT_RS13055
uniprot id: D6ZC75
names: Similarity
messages: Belongs to the GSP E family.

640132:SROT RS06975
gene id: 640132:SROT_RS06975
uniprot id: D6Z7C7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

640132:SROT RS13635
gene id: 640132:SROT_RS13635
uniprot id: D6ZCX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

640132:SROT RS03980
gene id: 640132:SROT_RS03980
uniprot id: D6ZDK1
names: Similarity
messages: Belongs to the WXG100 family.

640132:SROT RS11490
gene id: 640132:SROT_RS11490
uniprot id: D6ZAL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

640132:SROT RS01740
gene id: 640132:SROT_RS01740
uniprot id: D6ZB73
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

640132:SROT RS13445
gene id: 640132:SROT_RS13445
uniprot id: D6ZCF1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

640132:SROT RS10920
gene id: 640132:SROT_RS10920
uniprot id: D6Z9W2
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS08735
gene id: 640132:SROT_RS08735
uniprot id: D6Z8C8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

640132:SROT RS11100
gene id: 640132:SROT_RS11100
uniprot id: D6Z9Z8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

640132:SROT RS11475
gene id: 640132:SROT_RS11475
uniprot id: D6ZAK7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

640132:SROT RS10465
gene id: 640132:SROT_RS10465
uniprot id: D6Z9B8
names: Similarity
messages: Belongs to the peptidase M13 family.

640132:SROT RS05435
gene id: 640132:SROT_RS05435
uniprot id: D6ZF33
names: Similarity
messages: Belongs to the peptidase U62 family.

640132:SROT RS05550
gene id: 640132:SROT_RS05550
uniprot id: D6ZF54
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

640132:SROT RS06545
gene id: 640132:SROT_RS06545
uniprot id: D6ZFQ5
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

640132:SROT RS07275
gene id: 640132:SROT_RS07275
uniprot id: D6Z7I7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

640132:SROT RS08205
gene id: 640132:SROT_RS08205
uniprot id: D6Z819
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

640132:SROT RS09260
gene id: 640132:SROT_RS09260
uniprot id: D6Z8N0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

640132:SROT RS05755
gene id: 640132:SROT_RS05755
uniprot id: D6ZF95
names: Similarity
messages: Belongs to the acyltransferase PapA5 family.

640132:SROT RS03110
gene id: 640132:SROT_RS03110
uniprot id: D6ZCQ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

640132:SROT RS13015
gene id: 640132:SROT_RS13015
uniprot id: D6ZC67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

640132:SROT RS02765
gene id: 640132:SROT_RS02765
uniprot id: D6ZCJ0
names: Similarity
messages: Belongs to the CFA/CMAS family.

640132:SROT RS12550
gene id: 640132:SROT_RS12550
uniprot id: D6ZBJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

640132:SROT RS10450
gene id: 640132:SROT_RS10450
uniprot id: D6Z9B5
names: Similarity
messages: Belongs to the peptidase S1C family.

640132:SROT RS03470
gene id: 640132:SROT_RS03470
uniprot id: D6ZDA6
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

640132:SROT RS01700
gene id: 640132:SROT_RS01700
uniprot id: D6ZB65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class II aldolase/RraA-like family.
messages: Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
messages: Homotrimer.

640132:SROT RS05270
gene id: 640132:SROT_RS05270
uniprot id: D6ZF00
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

640132:SROT RS12640
gene id: 640132:SROT_RS12640
uniprot id: D6ZBL2
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS07250
gene id: 640132:SROT_RS07250
uniprot id: D6Z7I2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

640132:SROT RS05715
gene id: 640132:SROT_RS05715
uniprot id: D6ZF88
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

640132:SROT RS04160
gene id: 640132:SROT_RS04160
uniprot id: D6ZE23
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.

640132:SROT RS05440
gene id: 640132:SROT_RS05440
uniprot id: D6ZF34
names: Similarity
messages: Belongs to the peptidase U62 family.

640132:SROT RS03950
gene id: 640132:SROT_RS03950
uniprot id: D6ZDJ6
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS13220
gene id: 640132:SROT_RS13220
uniprot id: D6ZCA6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MurCDEF family. MurT subfamily.
messages: Forms a heterodimer with GatD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.

640132:SROT RS03940
gene id: 640132:SROT_RS03940
uniprot id: D6ZDJ4
names: Similarity
messages: Belongs to the FAD-binding monooxygenase family.

640132:SROT RS10820
gene id: 640132:SROT_RS10820
uniprot id: D6Z9U2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

640132:SROT RS08965
gene id: 640132:SROT_RS08965
uniprot id: D6Z8H4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

640132:SROT RS00880
gene id: 640132:SROT_RS00880
uniprot id: D6ZAB6
names: Similarity
messages: Belongs to the LOG family.

640132:SROT RS02565
gene id: 640132:SROT_RS02565
uniprot id: D6ZC16
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

640132:SROT RS10145
gene id: 640132:SROT_RS10145
uniprot id: D6Z958
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

640132:SROT RS10810
gene id: 640132:SROT_RS10810
uniprot id: D6Z9U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

640132:SROT RS14925
gene id: 640132:SROT_RS14925
uniprot id: D6ZEC8
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

640132:SROT RS05240
gene id: 640132:SROT_RS05240
uniprot id: D6ZEZ4
names: Similarity
messages: Belongs to the Dps family.

640132:SROT RS09835
gene id: 640132:SROT_RS09835
uniprot id: D6Z8Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

640132:SROT RS06430
gene id: 640132:SROT_RS06430
uniprot id: D6ZFN2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
messages: Tetramer of two alpha and two beta subunits.

640132:SROT RS09425
gene id: 640132:SROT_RS09425
uniprot id: D6Z8R4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.

640132:SROT RS02370
gene id: 640132:SROT_RS02370
uniprot id: D6ZBY3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

640132:SROT RS08810
gene id: 640132:SROT_RS08810
uniprot id: D6Z8E3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

640132:SROT RS02365
gene id: 640132:SROT_RS02365
uniprot id: D6ZBY2
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

640132:SROT RS13215
gene id: 640132:SROT_RS13215
uniprot id: D6ZCA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

640132:SROT RS12700
gene id: 640132:SROT_RS12700
uniprot id: D6ZBM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

640132:SROT RS08015
gene id: 640132:SROT_RS08015
uniprot id: D6Z7Y2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic ubiquitin-like protein family.
messages: Is modified by deamidation of its C-terminal glutamine to glutamate by the deamidase Dop, a prerequisite to the subsequent pupylation process.
messages: Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.
messages: Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.
messages: The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome.

640132:SROT RS05450
gene id: 640132:SROT_RS05450
uniprot id: D6ZF36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

640132:SROT RS11025
gene id: 640132:SROT_RS11025
uniprot id: D6Z9Y3
names: Function
names: Similarity
messages: Belongs to the cyanase family.
messages: Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.

640132:SROT RS13995
gene id: 640132:SROT_RS13995
uniprot id: D6ZD38
names: Cofactor
messages: Binds 1 FAD per subunit.

640132:SROT RS05380
gene id: 640132:SROT_RS05380
uniprot id: D6ZF22
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

640132:SROT RS08795
gene id: 640132:SROT_RS08795
uniprot id: D6Z8E0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

640132:SROT RS00490
gene id: 640132:SROT_RS00490
uniprot id: D6Z9Q9
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS09460
gene id: 640132:SROT_RS09460
uniprot id: D6Z8S1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS06170
gene id: 640132:SROT_RS06170
uniprot id: D6ZFI0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS09030
gene id: 640132:SROT_RS09030
uniprot id: D6Z8I7
names: Similarity
messages: Belongs to the UPF0145 family.

640132:SROT RS07435
gene id: 640132:SROT_RS07435
uniprot id: D6Z7L8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

640132:SROT RS02940
gene id: 640132:SROT_RS02940
uniprot id: D6ZCM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

640132:SROT RS07205
gene id: 640132:SROT_RS07205
uniprot id: D6Z7H2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

640132:SROT RS05260
gene id: 640132:SROT_RS05260
uniprot id: D6ZEZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

640132:SROT RS08765
gene id: 640132:SROT_RS08765
uniprot id: D6Z8D4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

640132:SROT RS07765
gene id: 640132:SROT_RS07765
uniprot id: D6Z7T2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

640132:SROT RS02755
gene id: 640132:SROT_RS02755
uniprot id: D6ZCI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

640132:SROT RS05710
gene id: 640132:SROT_RS05710
uniprot id: D6ZF87
names: Similarity
messages: Belongs to the glycosyl hydrolase 100 family.

640132:SROT RS01010
gene id: 640132:SROT_RS01010
uniprot id: D6ZAE2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

640132:SROT RS13125
gene id: 640132:SROT_RS13125
uniprot id: D6ZC89
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

640132:SROT RS08985
gene id: 640132:SROT_RS08985
uniprot id: D6Z8H8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

640132:SROT RS16605
gene id: 640132:SROT_RS16605
uniprot id: D6ZBJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

640132:SROT RS08270
gene id: 640132:SROT_RS08270
uniprot id: D6Z833
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

640132:SROT RS14105
gene id: 640132:SROT_RS14105
uniprot id: D6ZD58
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

640132:SROT RS01065
gene id: 640132:SROT_RS01065
uniprot id: D6ZAF3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

640132:SROT RS11580
gene id: 640132:SROT_RS11580
uniprot id: D6ZAM9
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

640132:SROT RS13915
gene id: 640132:SROT_RS13915
uniprot id: D6ZD22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan.
messages: Belongs to the emb family.
messages: Cell membrane
messages: Membrane

640132:SROT RS14150
gene id: 640132:SROT_RS14150
uniprot id: D6ZD65
names: Function
names: Similarity
messages: Belongs to the UPF0677 family.
messages: Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.

640132:SROT RS02660
gene id: 640132:SROT_RS02660
uniprot id: D6ZCH0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

640132:SROT RS07500
gene id: 640132:SROT_RS07500
uniprot id: D6Z7N1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

640132:SROT RS13265
gene id: 640132:SROT_RS13265
uniprot id: D6ZCB5
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

640132:SROT RS08215
gene id: 640132:SROT_RS08215
uniprot id: D6Z822
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

640132:SROT RS03915
gene id: 640132:SROT_RS03915
uniprot id: D6ZDI9
names: Similarity
messages: Belongs to the TfdA dioxygenase family.
messages: Belongs to the clavaminate synthase family.

640132:SROT RS01100
gene id: 640132:SROT_RS01100
uniprot id: D6ZAG0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

640132:SROT RS13480
gene id: 640132:SROT_RS13480
uniprot id: D6ZCF8
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily.
messages: Probably catalyzes the conversion of hercynylcysteine sulfoxide to ergothioneine.

640132:SROT RS10115
gene id: 640132:SROT_RS10115
uniprot id: D6Z952
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

640132:SROT RS08815
gene id: 640132:SROT_RS08815
uniprot id: D6Z8E4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase-binding protein RbpA family.
messages: Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
messages: Forms a complex with the RNAP catalytic core and with free principal sigma factors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS06500
gene id: 640132:SROT_RS06500
uniprot id: D6ZFP6
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

640132:SROT RS14590
gene id: 640132:SROT_RS14590
uniprot id: D6ZDT1
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family. Carboxylic acid reductase subfamily.
messages: Binds 1 phosphopantetheine covalently.
messages: Catalyzes the ATP- and NADPH-dependent reduction of carboxylic acids to the corresponding aldehydes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain likely catalyzes substrate activation by formation of an initial acyl-AMP intermediate, the central region contains the phosphopantetheine attachment site, and the C-terminal domain catalyzes the reduction by NADPH of the intermediate thioester formed from the attack of the phosphopantetheine thiol at the carbonyl carbon of acyl-AMP.

640132:SROT RS13695
gene id: 640132:SROT_RS13695
uniprot id: D6ZCX9
names: Similarity
messages: Belongs to the UPF0234 family.

640132:SROT RS08345
gene id: 640132:SROT_RS08345
uniprot id: D6Z849
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

640132:SROT RS04980
gene id: 640132:SROT_RS04980
uniprot id: D6ZET9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

640132:SROT RS06775
gene id: 640132:SROT_RS06775
uniprot id: D6Z788
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

640132:SROT RS08750
gene id: 640132:SROT_RS08750
uniprot id: D6Z8D1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

640132:SROT RS02320
gene id: 640132:SROT_RS02320
uniprot id: D6ZBX3
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

640132:SROT RS07180
gene id: 640132:SROT_RS07180
uniprot id: D6Z7G7
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

640132:SROT RS08155
gene id: 640132:SROT_RS08155
uniprot id: D6Z809
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

640132:SROT RS13925
gene id: 640132:SROT_RS13925
uniprot id: D6ZD24
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS10185
gene id: 640132:SROT_RS10185
uniprot id: D6Z966
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

640132:SROT RS09665
gene id: 640132:SROT_RS09665
uniprot id: D6Z8W2
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

640132:SROT RS07515
gene id: 640132:SROT_RS07515
uniprot id: D6Z7N4
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS00695
gene id: 640132:SROT_RS00695
uniprot id: D6ZA79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone.
messages: Homodimer.

640132:SROT RS03840
gene id: 640132:SROT_RS03840
uniprot id: D6ZDH4
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

640132:SROT RS09180
gene id: 640132:SROT_RS09180
uniprot id: D6Z8L3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

640132:SROT RS14835
gene id: 640132:SROT_RS14835
uniprot id: D6ZDY0
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

640132:SROT RS00855
gene id: 640132:SROT_RS00855
uniprot id: D6ZAB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane
messages: Membrane

640132:SROT RS02165
gene id: 640132:SROT_RS02165
uniprot id: D6ZBU1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

640132:SROT RS02055
gene id: 640132:SROT_RS02055
uniprot id: D6ZBR8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

640132:SROT RS03340
gene id: 640132:SROT_RS03340
uniprot id: D6ZD81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the UPF0157 (GrpB) family.
messages: In the N-terminal section; belongs to the CoaE family.

640132:SROT RS03520
gene id: 640132:SROT_RS03520
uniprot id: D6ZDB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

640132:SROT RS14485
gene id: 640132:SROT_RS14485
uniprot id: D6ZDR3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

640132:SROT RS03820
gene id: 640132:SROT_RS03820
uniprot id: D6ZDH0
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
messages: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).

640132:SROT RS05705
gene id: 640132:SROT_RS05705
uniprot id: D6ZF86
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS14220
gene id: 640132:SROT_RS14220
uniprot id: D6ZDK8
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS12775
gene id: 640132:SROT_RS12775
uniprot id: D6ZBN9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

640132:SROT RS15005
gene id: 640132:SROT_RS15005
uniprot id: D6ZEE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

640132:SROT RS13170
gene id: 640132:SROT_RS13170
uniprot id: D6ZC96
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

640132:SROT RS10050
gene id: 640132:SROT_RS10050
uniprot id: D6Z939
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS08150
gene id: 640132:SROT_RS08150
uniprot id: D6Z808
names: Similarity
messages: Belongs to the TfdA dioxygenase family.

640132:SROT RS10800
gene id: 640132:SROT_RS10800
uniprot id: D6Z9T8
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

640132:SROT RS07495
gene id: 640132:SROT_RS07495
uniprot id: D6Z7N0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

640132:SROT RS12535
gene id: 640132:SROT_RS12535
uniprot id: D6ZBJ1
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

640132:SROT RS04185
gene id: 640132:SROT_RS04185
uniprot id: D6ZE28
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

640132:SROT RS11630
gene id: 640132:SROT_RS11630
uniprot id: D6ZAN9
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

640132:SROT RS02155
gene id: 640132:SROT_RS02155
uniprot id: D6ZBT9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS06415
gene id: 640132:SROT_RS06415
uniprot id: D6ZFM9
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Electron transport system for the ribonucleotide reductase system NrdEF.

640132:SROT RS03625
gene id: 640132:SROT_RS03625
uniprot id: D6ZDD6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

640132:SROT RS05290
gene id: 640132:SROT_RS05290
uniprot id: D6ZF04
names: Similarity
messages: Belongs to the asparagine synthetase family.

640132:SROT RS01770
gene id: 640132:SROT_RS01770
uniprot id: D6ZB79
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

640132:SROT RS09880
gene id: 640132:SROT_RS09880
uniprot id: D6Z904
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.
messages: Belongs to the MshB deacetylase family. Mca subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Monomer.

640132:SROT RS04935
gene id: 640132:SROT_RS04935
uniprot id: D6ZET0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

640132:SROT RS12915
gene id: 640132:SROT_RS12915
uniprot id: D6ZC48
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS01695
gene id: 640132:SROT_RS01695
uniprot id: D6ZB64
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M.tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine results in repulsion of the peptides.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer.
messages: In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.
messages: In the N-terminal section; belongs to the LPG synthetase family.
messages: Membrane

640132:SROT RS15110
gene id: 640132:SROT_RS15110
uniprot id: D6ZEG8
names: Similarity
messages: Belongs to the thioesterase family.

640132:SROT RS13010
gene id: 640132:SROT_RS13010
uniprot id: D6ZC66
names: Similarity
messages: Belongs to the adenylyl cyclase class-3 family.

640132:SROT RS08905
gene id: 640132:SROT_RS08905
uniprot id: D6Z8G2
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

640132:SROT RS02865
gene id: 640132:SROT_RS02865
uniprot id: D6ZCK8
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS02240
gene id: 640132:SROT_RS02240
uniprot id: D6ZBV7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

640132:SROT RS07000
gene id: 640132:SROT_RS07000
uniprot id: D6Z7D2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

640132:SROT RS11665
gene id: 640132:SROT_RS11665
uniprot id: D6ZAP6
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS12575
gene id: 640132:SROT_RS12575
uniprot id: D6ZBJ9
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS03480
gene id: 640132:SROT_RS03480
uniprot id: D6ZDA8
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS03845
gene id: 640132:SROT_RS03845
uniprot id: D6ZDH5
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

640132:SROT RS04760
gene id: 640132:SROT_RS04760
uniprot id: D6ZEP5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

640132:SROT RS04445
gene id: 640132:SROT_RS04445
uniprot id: D6ZE78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

640132:SROT RS13800
gene id: 640132:SROT_RS13800
uniprot id: D6ZD00
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Could possibly oxidize fatty acids using specific components.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS02200
gene id: 640132:SROT_RS02200
uniprot id: D6ZBU9
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase family.
messages: Binds 1 FAD per subunit.

640132:SROT RS01375
gene id: 640132:SROT_RS01375
uniprot id: D6ZAZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

640132:SROT RS06850
gene id: 640132:SROT_RS06850
uniprot id: D6Z7A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EspG family.
messages: Cytoplasm

640132:SROT RS10440
gene id: 640132:SROT_RS10440
uniprot id: D6Z9B3
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS00785
gene id: 640132:SROT_RS00785
uniprot id: D6ZA97
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

640132:SROT RS07680
gene id: 640132:SROT_RS07680
uniprot id: D6Z7R7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

640132:SROT RS04375
gene id: 640132:SROT_RS04375
uniprot id: D6ZE64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell inner membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

640132:SROT RS07900
gene id: 640132:SROT_RS07900
uniprot id: D6Z7V9
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

640132:SROT RS02420
gene id: 640132:SROT_RS02420
uniprot id: D6ZBZ3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

640132:SROT RS13335
gene id: 640132:SROT_RS13335
uniprot id: D6ZCC9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS13325
gene id: 640132:SROT_RS13325
uniprot id: D6ZCC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

640132:SROT RS11280
gene id: 640132:SROT_RS11280
uniprot id: D6ZA34
names: Similarity
messages: Belongs to the P(II) protein family.

640132:SROT RS11425
gene id: 640132:SROT_RS11425
uniprot id: D6ZAJ7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

640132:SROT RS01400
gene id: 640132:SROT_RS01400
uniprot id: D6ZB03
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

640132:SROT RS00740
gene id: 640132:SROT_RS00740
uniprot id: D6ZA88
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

640132:SROT RS09990
gene id: 640132:SROT_RS09990
uniprot id: D6Z926
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

640132:SROT RS13535
gene id: 640132:SROT_RS13535
uniprot id: D6ZCV1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

640132:SROT RS00560
gene id: 640132:SROT_RS00560
uniprot id: D6Z9S3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

640132:SROT RS02195
gene id: 640132:SROT_RS02195
uniprot id: D6ZBU8
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

640132:SROT RS11270
gene id: 640132:SROT_RS11270
uniprot id: D6ZA32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan.
messages: Belongs to the emb family.
messages: Cell membrane
messages: Membrane

640132:SROT RS01795
gene id: 640132:SROT_RS01795
uniprot id: D6ZB84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein bS18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

640132:SROT RS14615
gene id: 640132:SROT_RS14615
uniprot id: D6ZDT6
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS06875
gene id: 640132:SROT_RS06875
uniprot id: D6Z7A7
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

640132:SROT RS02330
gene id: 640132:SROT_RS02330
uniprot id: D6ZBX5
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS07375
gene id: 640132:SROT_RS07375
uniprot id: D6Z7K6
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

640132:SROT RS01395
gene id: 640132:SROT_RS01395
uniprot id: D6ZB02
names: Cofactor
messages: Binds 1 Fe(2+) ion per subunit.

640132:SROT RS01030
gene id: 640132:SROT_RS01030
uniprot id: D6ZAE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

640132:SROT RS14005
gene id: 640132:SROT_RS14005
uniprot id: D6ZD40
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

640132:SROT RS09820
gene id: 640132:SROT_RS09820
uniprot id: D6Z8Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

640132:SROT RS03105
gene id: 640132:SROT_RS03105
uniprot id: D6ZCQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm

640132:SROT RS09320
gene id: 640132:SROT_RS09320
uniprot id: D6Z8P3
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

640132:SROT RS06665
gene id: 640132:SROT_RS06665
uniprot id: D6ZFS4
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS13100
gene id: 640132:SROT_RS13100
uniprot id: D6ZC84
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.

640132:SROT RS02685
gene id: 640132:SROT_RS02685
uniprot id: D6ZCH5
names: Similarity
messages: Belongs to the glutamine synthetase family.

640132:SROT RS05315
gene id: 640132:SROT_RS05315
uniprot id: D6ZF09
names: Caution
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds 2 heme c groups covalently per subunit.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit.

640132:SROT RS09620
gene id: 640132:SROT_RS09620
uniprot id: D6Z8V3
names: Similarity
messages: Belongs to the peptidase A24 family.

640132:SROT RS05490
gene id: 640132:SROT_RS05490
uniprot id: D6ZF44
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

640132:SROT RS11440
gene id: 640132:SROT_RS11440
uniprot id: D6ZAK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

640132:SROT RS14440
gene id: 640132:SROT_RS14440
uniprot id: D6ZDQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

640132:SROT RS05475
gene id: 640132:SROT_RS05475
uniprot id: D6ZF41
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

640132:SROT RS03440
gene id: 640132:SROT_RS03440
uniprot id: D6ZDA0
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

640132:SROT RS03500
gene id: 640132:SROT_RS03500
uniprot id: D6ZDB2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

640132:SROT RS01430
gene id: 640132:SROT_RS01430
uniprot id: D6ZB09
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

640132:SROT RS01705
gene id: 640132:SROT_RS01705
uniprot id: D6ZB66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

640132:SROT RS07285
gene id: 640132:SROT_RS07285
uniprot id: D6Z7I9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

640132:SROT RS09315
gene id: 640132:SROT_RS09315
uniprot id: D6Z8P2
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS14920
gene id: 640132:SROT_RS14920
uniprot id: D6ZEC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

640132:SROT RS08160
gene id: 640132:SROT_RS08160
uniprot id: D6Z810
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

640132:SROT RS05595
gene id: 640132:SROT_RS05595
uniprot id: D6ZF64
names: Similarity
messages: Belongs to the Nudix hydrolase family. PCD1 subfamily.

640132:SROT RS11220
gene id: 640132:SROT_RS11220
uniprot id: D6ZA21
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

640132:SROT RS13930
gene id: 640132:SROT_RS13930
uniprot id: D6ZD25
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS14095
gene id: 640132:SROT_RS14095
uniprot id: D6ZD56
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

640132:SROT RS06215
gene id: 640132:SROT_RS06215
uniprot id: D6ZFI9
names: Function
messages: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.

640132:SROT RS11445
gene id: 640132:SROT_RS11445
uniprot id: D6ZAK1
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS16600
gene id: 640132:SROT_RS16600
uniprot id: D6ZBJ5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

640132:SROT RS02000
gene id: 640132:SROT_RS02000
uniprot id: D6ZBQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

640132:SROT RS08460
gene id: 640132:SROT_RS08460
uniprot id: D6Z871
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS01935
gene id: 640132:SROT_RS01935
uniprot id: D6ZBB2
names: Similarity
messages: Belongs to the glutamate synthase family.

640132:SROT RS05875
gene id: 640132:SROT_RS05875
uniprot id: D6ZFC0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

640132:SROT RS12125
gene id: 640132:SROT_RS12125
uniprot id: D6ZBB6
names: Similarity
messages: Belongs to the PrpD family.

640132:SROT RS14985
gene id: 640132:SROT_RS14985
uniprot id: D6ZEE0
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

640132:SROT RS00665
gene id: 640132:SROT_RS00665
uniprot id: D6ZA74
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.
messages: Reversible hydration of carbon dioxide.

640132:SROT RS07840
gene id: 640132:SROT_RS07840
uniprot id: D6Z7U6
names: Similarity
messages: Belongs to the TlyA family.

640132:SROT RS04785
gene id: 640132:SROT_RS04785
uniprot id: D6ZEQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

640132:SROT RS06790
gene id: 640132:SROT_RS06790
uniprot id: D6Z791
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

640132:SROT RS13340
gene id: 640132:SROT_RS13340
uniprot id: D6ZCD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

640132:SROT RS00525
gene id: 640132:SROT_RS00525
uniprot id: D6Z9R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

640132:SROT RS01555
gene id: 640132:SROT_RS01555
uniprot id: D6ZB35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CbxX/CfxQ family.
messages: Cytoplasm

640132:SROT RS06560
gene id: 640132:SROT_RS06560
uniprot id: D6ZFQ7
names: Similarity
messages: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.

640132:SROT RS10265
gene id: 640132:SROT_RS10265
uniprot id: D6Z982
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

640132:SROT RS04275
gene id: 640132:SROT_RS04275
uniprot id: D6ZE46
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

640132:SROT RS01945
gene id: 640132:SROT_RS01945
uniprot id: D6ZBP6
names: Subcellular Location Annotation
messages: Secreted

640132:SROT RS01480
gene id: 640132:SROT_RS01480
uniprot id: D6ZB19
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS05410
gene id: 640132:SROT_RS05410
uniprot id: D6ZF28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

640132:SROT RS03075
gene id: 640132:SROT_RS03075
uniprot id: D6ZCQ0
names: Function
names: Similarity
messages: Belongs to the UPF0677 family.
messages: Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.

640132:SROT RS08755
gene id: 640132:SROT_RS08755
uniprot id: D6Z8D2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

640132:SROT RS07980
gene id: 640132:SROT_RS07980
uniprot id: D6Z7X5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

640132:SROT RS02415
gene id: 640132:SROT_RS02415
uniprot id: D6ZBZ2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

640132:SROT RS05360
gene id: 640132:SROT_RS05360
uniprot id: D6ZF18
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Exonuclease that cleaves single-stranded 3' overhangs of double-stranded RNA.
messages: Homodimer.

640132:SROT RS09445
gene id: 640132:SROT_RS09445
uniprot id: D6Z8R8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

640132:SROT RS12100
gene id: 640132:SROT_RS12100
uniprot id: D6ZAX7
names: Similarity
messages: Belongs to the CdaR family.

640132:SROT RS02960
gene id: 640132:SROT_RS02960
uniprot id: D6ZCM6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

640132:SROT RS11175
gene id: 640132:SROT_RS11175
uniprot id: D6ZA13
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

640132:SROT RS05365
gene id: 640132:SROT_RS05365
uniprot id: D6ZF19
names: Cofactor
names: Similarity
messages: Belongs to the class-II DAHP synthase family.
messages: Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.

640132:SROT RS03620
gene id: 640132:SROT_RS03620
uniprot id: D6ZDD5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

640132:SROT RS10270
gene id: 640132:SROT_RS10270
uniprot id: D6Z983
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.

640132:SROT RS10275
gene id: 640132:SROT_RS10275
uniprot id: D6Z984
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

640132:SROT RS11275
gene id: 640132:SROT_RS11275
uniprot id: D6ZA33
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

640132:SROT RS00105
gene id: 640132:SROT_RS00105
uniprot id: D6Z9I5
names: Similarity
messages: Belongs to the CFA/CMAS family.

640132:SROT RS13705
gene id: 640132:SROT_RS13705
uniprot id: D6ZCY1
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

640132:SROT RS07045
gene id: 640132:SROT_RS07045
uniprot id: D6Z7E1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

640132:SROT RS09305
gene id: 640132:SROT_RS09305
uniprot id: D6Z8P0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

640132:SROT RS06670
gene id: 640132:SROT_RS06670
uniprot id: D6Z769
names: Similarity
messages: Belongs to the MmpS family.

640132:SROT RS05255
gene id: 640132:SROT_RS05255
uniprot id: D6ZEZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

640132:SROT RS06305
gene id: 640132:SROT_RS06305
uniprot id: D6ZFK7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

640132:SROT RS02850
gene id: 640132:SROT_RS02850
uniprot id: D6ZCK5
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

640132:SROT RS05985
gene id: 640132:SROT_RS05985
uniprot id: D6ZFE1
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

640132:SROT RS05590
gene id: 640132:SROT_RS05590
uniprot id: D6ZF63
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

640132:SROT RS13615
gene id: 640132:SROT_RS13615
uniprot id: D6ZCW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

640132:SROT RS02270
gene id: 640132:SROT_RS02270
uniprot id: D6ZBW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

640132:SROT RS06250
gene id: 640132:SROT_RS06250
uniprot id: D6ZFJ6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

640132:SROT RS05625
gene id: 640132:SROT_RS05625
uniprot id: D6ZF70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

640132:SROT RS08730
gene id: 640132:SROT_RS08730
uniprot id: D6Z8C7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

640132:SROT RS10410
gene id: 640132:SROT_RS10410
uniprot id: D6Z9A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

640132:SROT RS04100
gene id: 640132:SROT_RS04100
uniprot id: D6ZE11
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

640132:SROT RS03755
gene id: 640132:SROT_RS03755
uniprot id: D6ZDF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EccB family.
messages: Membrane

640132:SROT RS07290
gene id: 640132:SROT_RS07290
uniprot id: D6Z7J0
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

640132:SROT RS00925
gene id: 640132:SROT_RS00925
uniprot id: D6ZAC5
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS04260
gene id: 640132:SROT_RS04260
uniprot id: D6ZE43
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

640132:SROT RS12815
gene id: 640132:SROT_RS12815
uniprot id: D6ZC30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DivIVA family.
messages: Cytoplasm

640132:SROT RS03450
gene id: 640132:SROT_RS03450
uniprot id: D6ZDA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

640132:SROT RS03115
gene id: 640132:SROT_RS03115
uniprot id: D6ZCQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

640132:SROT RS00010
gene id: 640132:SROT_RS00010
uniprot id: D6Z9G8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

640132:SROT RS15360
gene id: 640132:SROT_RS15360
uniprot id: D6ZEL8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

640132:SROT RS07675
gene id: 640132:SROT_RS07675
uniprot id: D6Z7R6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

640132:SROT RS06865
gene id: 640132:SROT_RS06865
uniprot id: D6Z7A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EccD/Snm4 family.
messages: Membrane

640132:SROT RS02125
gene id: 640132:SROT_RS02125
uniprot id: D6ZBT3
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

640132:SROT RS03565
gene id: 640132:SROT_RS03565
uniprot id: D6ZDC3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS11840
gene id: 640132:SROT_RS11840
uniprot id: D6ZAS8
names: Similarity
messages: Belongs to the universal stress protein A family.

640132:SROT RS07480
gene id: 640132:SROT_RS07480
uniprot id: D6Z7M7
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

640132:SROT RS13405
gene id: 640132:SROT_RS13405
uniprot id: D6ZCE3
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

640132:SROT RS01525
gene id: 640132:SROT_RS01525
uniprot id: D6ZB29
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

640132:SROT RS03055
gene id: 640132:SROT_RS03055
uniprot id: D6ZCP6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

640132:SROT RS13835
gene id: 640132:SROT_RS13835
uniprot id: D6ZD07
names: Similarity
messages: Belongs to the peptidase S11 family.

640132:SROT RS03090
gene id: 640132:SROT_RS03090
uniprot id: D6ZCQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

640132:SROT RS02595
gene id: 640132:SROT_RS02595
uniprot id: D6ZC22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

640132:SROT RS07660
gene id: 640132:SROT_RS07660
uniprot id: D6Z7R3
names: Similarity
messages: Belongs to the peptidase S58 family.

640132:SROT RS13950
gene id: 640132:SROT_RS13950
uniprot id: D6ZD29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

640132:SROT RS12120
gene id: 640132:SROT_RS12120
uniprot id: D6ZBB5
names: Similarity
messages: Belongs to the phosphosulfolactate synthase family.

640132:SROT RS11460
gene id: 640132:SROT_RS11460
uniprot id: D6ZAK4
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

640132:SROT RS08540
gene id: 640132:SROT_RS08540
uniprot id: D6Z887
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

640132:SROT RS09565
gene id: 640132:SROT_RS09565
uniprot id: D6Z8U2
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

640132:SROT RS01950
gene id: 640132:SROT_RS01950
uniprot id: D6ZBP7
names: Similarity
messages: Belongs to the ABC transporter superfamily.

640132:SROT RS01595
gene id: 640132:SROT_RS01595
uniprot id: D6ZB44
names: Similarity
messages: Belongs to the MmpS family.

640132:SROT RS10865
gene id: 640132:SROT_RS10865
uniprot id: D6Z9V1
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS01715
gene id: 640132:SROT_RS01715
uniprot id: D6ZB68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

640132:SROT RS13350
gene id: 640132:SROT_RS13350
uniprot id: D6ZCD2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

640132:SROT RS02690
gene id: 640132:SROT_RS02690
uniprot id: D6ZCH6
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

640132:SROT RS09090
gene id: 640132:SROT_RS09090
uniprot id: D6Z8J5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

640132:SROT RS14335
gene id: 640132:SROT_RS14335
uniprot id: D6ZDN2
names: Similarity
messages: Belongs to the MoaD family.

640132:SROT RS03460
gene id: 640132:SROT_RS03460
uniprot id: D6ZDA4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

640132:SROT RS08910
gene id: 640132:SROT_RS08910
uniprot id: D6Z8G3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

640132:SROT RS02115
gene id: 640132:SROT_RS02115
uniprot id: D6ZBT1
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

640132:SROT RS13075
gene id: 640132:SROT_RS13075
uniprot id: D6ZC79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

640132:SROT RS11330
gene id: 640132:SROT_RS11330
uniprot id: D6ZA44
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

640132:SROT RS06125
gene id: 640132:SROT_RS06125
uniprot id: D6ZFH2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

640132:SROT RS09690
gene id: 640132:SROT_RS09690
uniprot id: D6Z8W7
names: Similarity
messages: Belongs to the UPF0102 family.

640132:SROT RS11825
gene id: 640132:SROT_RS11825
uniprot id: D6ZAS5
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

640132:SROT RS15020
gene id: 640132:SROT_RS15020
uniprot id: D6ZEE9
names: Similarity
messages: Belongs to the LppX/LprAFG lipoprotein family.

640132:SROT RS13190
gene id: 640132:SROT_RS13190
uniprot id: D6ZCA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

640132:SROT RS08855
gene id: 640132:SROT_RS08855
uniprot id: D6Z8F2
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

640132:SROT RS02575
gene id: 640132:SROT_RS02575
uniprot id: D6ZC18
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

640132:SROT RS03445
gene id: 640132:SROT_RS03445
uniprot id: D6ZDA1
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

640132:SROT RS08125
gene id: 640132:SROT_RS08125
uniprot id: D6Z803
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

640132:SROT RS06320
gene id: 640132:SROT_RS06320
uniprot id: D6ZFL0
names: Similarity
messages: Belongs to the peptidase S1C family.

640132:SROT RS07255
gene id: 640132:SROT_RS07255
uniprot id: D6Z7I3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

640132:SROT RS13195
gene id: 640132:SROT_RS13195
uniprot id: D6ZCA1
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

640132:SROT RS03210
gene id: 640132:SROT_RS03210
uniprot id: D6ZCS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

640132:SROT RS10965
gene id: 640132:SROT_RS10965
uniprot id: D6Z9X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

640132:SROT RS15220
gene id: 640132:SROT_RS15220
uniprot id: D6ZEI7
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

640132:SROT RS07050
gene id: 640132:SROT_RS07050
uniprot id: D6Z7E2
names: Similarity
messages: Belongs to the UreD family.

640132:SROT RS08225
gene id: 640132:SROT_RS08225
uniprot id: D6Z824
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

640132:SROT RS05310
gene id: 640132:SROT_RS05310
uniprot id: D6ZF08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Cell membrane
messages: Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.

640132:SROT RS13210
gene id: 640132:SROT_RS13210
uniprot id: D6ZCA4
names: Similarity
messages: Belongs to the universal stress protein A family.

640132:SROT RS03900
gene id: 640132:SROT_RS03900
uniprot id: D6ZDI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

640132:SROT RS08065
gene id: 640132:SROT_RS08065
uniprot id: D6Z7Z2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

640132:SROT RS04430
gene id: 640132:SROT_RS04430
uniprot id: D6ZE75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

640132:SROT RS00670
gene id: 640132:SROT_RS00670
uniprot id: D6ZA75
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

640132:SROT RS10350
gene id: 640132:SROT_RS10350
uniprot id: D6Z996
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

640132:SROT RS07310
gene id: 640132:SROT_RS07310
uniprot id: D6Z7J4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

640132:SROT RS14600
gene id: 640132:SROT_RS14600
uniprot id: D6ZDT3
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS07780
gene id: 640132:SROT_RS07780
uniprot id: D6Z7T5
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS09545
gene id: 640132:SROT_RS09545
uniprot id: D6Z8T8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

640132:SROT RS10880
gene id: 640132:SROT_RS10880
uniprot id: D6Z9V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

640132:SROT RS06400
gene id: 640132:SROT_RS06400
uniprot id: D6ZFM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

640132:SROT RS05670
gene id: 640132:SROT_RS05670
uniprot id: D6ZF79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

640132:SROT RS09375
gene id: 640132:SROT_RS09375
uniprot id: D6Z8Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

640132:SROT RS13110
gene id: 640132:SROT_RS13110
uniprot id: D6ZC86
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS11135
gene id: 640132:SROT_RS11135
uniprot id: D6ZA05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Cell membrane

640132:SROT RS06225
gene id: 640132:SROT_RS06225
uniprot id: D6ZFJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

640132:SROT RS12825
gene id: 640132:SROT_RS12825
uniprot id: D6ZC32
names: Similarity
messages: Belongs to the YggT family.

640132:SROT RS09955
gene id: 640132:SROT_RS09955
uniprot id: D6Z919
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

640132:SROT RS12965
gene id: 640132:SROT_RS12965
uniprot id: D6ZC58
names: Similarity
messages: Belongs to the fatty acid desaturase type 2 family.

640132:SROT RS08305
gene id: 640132:SROT_RS08305
uniprot id: D6Z840
names: Activity Regulation
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A peripheral cell membrane enzyme that catalyzes the oxidative decarboxylation of pyruvate to form acetate and CO(2). It channels electrons from the cytoplasm to the respiratory chain at the cell membrane via ubiquinone.
messages: Belongs to the TPP enzyme family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Cell inner membrane
messages: Has 4 domains; the Pyr domain which binds the pyrimidine moiety of the thiamine pyrophosphate cofactor, the FAD-binding domain, the PP-binding domain which binds the pyrophosphate portion of thiamine pyrophosphate and the C-terminal membrane binding region. The C-terminus is held closely against the rest of the protein and covers the active site; during activation it unfolds from the rest of the protein and forms an amphipathic helix upon membrane binding, exposing the active site.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The C-terminus inhibits activity; it has to move for the enzyme to be active. Activated by lipid-binding, which occurs via the C-terminus.

640132:SROT RS01780
gene id: 640132:SROT_RS01780
uniprot id: D6ZB81
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

640132:SROT RS00485
gene id: 640132:SROT_RS00485
uniprot id: D6Z9Q8
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS15210
gene id: 640132:SROT_RS15210
uniprot id: D6ZEI5
names: Similarity
messages: Belongs to the pirin family.

640132:SROT RS13230
gene id: 640132:SROT_RS13230
uniprot id: D6ZCA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Cytoplasm
messages: Homodimer.

640132:SROT RS10110
gene id: 640132:SROT_RS10110
uniprot id: D6Z951
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

640132:SROT RS04255
gene id: 640132:SROT_RS04255
uniprot id: D6ZE42
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

640132:SROT RS11205
gene id: 640132:SROT_RS11205
uniprot id: D6ZA18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

640132:SROT RS13425
gene id: 640132:SROT_RS13425
uniprot id: D6ZCE7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

640132:SROT RS08445
gene id: 640132:SROT_RS08445
uniprot id: D6Z868
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell inner membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

640132:SROT RS12405
gene id: 640132:SROT_RS12405
uniprot id: D6ZBG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Cytoplasm

640132:SROT RS03570
gene id: 640132:SROT_RS03570
uniprot id: D6ZDC4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS04775
gene id: 640132:SROT_RS04775
uniprot id: D6ZEP8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

640132:SROT RS14820
gene id: 640132:SROT_RS14820
uniprot id: D6ZDX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

640132:SROT RS07560
gene id: 640132:SROT_RS07560
uniprot id: D6Z7P3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

640132:SROT RS09635
gene id: 640132:SROT_RS09635
uniprot id: D6Z8V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

640132:SROT RS14135
gene id: 640132:SROT_RS14135
uniprot id: D6ZD63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 85 family.
messages: Cell membrane
messages: Membrane

640132:SROT RS02785
gene id: 640132:SROT_RS02785
uniprot id: D6ZCJ2
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS08555
gene id: 640132:SROT_RS08555
uniprot id: D6Z891
names: Similarity
messages: Belongs to the DyP-type peroxidase family.

640132:SROT RS13620
gene id: 640132:SROT_RS13620
uniprot id: D6ZCW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

640132:SROT RS12480
gene id: 640132:SROT_RS12480
uniprot id: D6ZBI0
names: Similarity
messages: Belongs to the WXG100 family.

640132:SROT RS03175
gene id: 640132:SROT_RS03175
uniprot id: D6ZCS0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

640132:SROT RS14325
gene id: 640132:SROT_RS14325
uniprot id: D6ZDN0
names: Similarity
messages: Belongs to the non-flavoprotein flavin reductase family.

640132:SROT RS03515
gene id: 640132:SROT_RS03515
uniprot id: D6ZDB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

640132:SROT RS00015
gene id: 640132:SROT_RS00015
uniprot id: D6Z9G9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

640132:SROT RS12155
gene id: 640132:SROT_RS12155
uniprot id: D6ZBC2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Siderophore-Fe(3+) uptake transporter (SIUT) (TC 3.A.1.21) family.
messages: Cell inner membrane
messages: Forms a heterodimer with IrtB.
messages: Membrane

640132:SROT RS09800
gene id: 640132:SROT_RS09800
uniprot id: D6Z8Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

640132:SROT RS13165
gene id: 640132:SROT_RS13165
uniprot id: D6ZC95
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS09105
gene id: 640132:SROT_RS09105
uniprot id: D6Z8J8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

640132:SROT RS09585
gene id: 640132:SROT_RS09585
uniprot id: D6Z8U6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.

640132:SROT RS01540
gene id: 640132:SROT_RS01540
uniprot id: D6ZB32
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS03535
gene id: 640132:SROT_RS03535
uniprot id: D6ZDC0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS12690
gene id: 640132:SROT_RS12690
uniprot id: D6ZBM2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

640132:SROT RS00780
gene id: 640132:SROT_RS00780
uniprot id: D6ZA96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

640132:SROT RS14490
gene id: 640132:SROT_RS14490
uniprot id: D6ZDR4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

640132:SROT RS06440
gene id: 640132:SROT_RS06440
uniprot id: D6ZFN4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

640132:SROT RS00800
gene id: 640132:SROT_RS00800
uniprot id: D6ZAA0
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

640132:SROT RS00930
gene id: 640132:SROT_RS00930
uniprot id: D6ZAC6
names: Similarity
messages: Belongs to the peptidase C40 family.

640132:SROT RS11435
gene id: 640132:SROT_RS11435
uniprot id: D6ZAJ9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

640132:SROT RS02095
gene id: 640132:SROT_RS02095
uniprot id: D6ZBS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

640132:SROT RS07240
gene id: 640132:SROT_RS07240
uniprot id: D6Z7I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

640132:SROT RS09855
gene id: 640132:SROT_RS09855
uniprot id: D6Z8Z9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

640132:SROT RS15175
gene id: 640132:SROT_RS15175
uniprot id: D6ZEH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

640132:SROT RS10665
gene id: 640132:SROT_RS10665
uniprot id: D6Z9F4
names: Similarity
messages: Belongs to the MmpS family.

640132:SROT RS00760
gene id: 640132:SROT_RS00760
uniprot id: D6ZA92
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

640132:SROT RS02750
gene id: 640132:SROT_RS02750
uniprot id: D6ZCI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

640132:SROT RS14495
gene id: 640132:SROT_RS14495
uniprot id: D6ZDR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

640132:SROT RS13150
gene id: 640132:SROT_RS13150
uniprot id: D6ZC92
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

640132:SROT RS13650
gene id: 640132:SROT_RS13650
uniprot id: D6ZCX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

640132:SROT RS06220
gene id: 640132:SROT_RS06220
uniprot id: D6ZFJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

640132:SROT RS00545
gene id: 640132:SROT_RS00545
uniprot id: D6Z9S0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

640132:SROT RS12910
gene id: 640132:SROT_RS12910
uniprot id: D6ZC47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

640132:SROT RS06060
gene id: 640132:SROT_RS06060
uniprot id: D6ZFF8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

640132:SROT RS12805
gene id: 640132:SROT_RS12805
uniprot id: D6ZC28
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

640132:SROT RS04655
gene id: 640132:SROT_RS04655
uniprot id: D6ZEM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.
messages: Membrane

640132:SROT RS09910
gene id: 640132:SROT_RS09910
uniprot id: D6Z910
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS15050
gene id: 640132:SROT_RS15050
uniprot id: D6ZEF5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

640132:SROT RS04965
gene id: 640132:SROT_RS04965
uniprot id: D6ZET6
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

640132:SROT RS06055
gene id: 640132:SROT_RS06055
uniprot id: D6ZFF7
names: Similarity
messages: Belongs to the UPF0098 family.

640132:SROT RS09860
gene id: 640132:SROT_RS09860
uniprot id: D6Z900
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS09825
gene id: 640132:SROT_RS09825
uniprot id: D6Z8Z3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

640132:SROT RS10055
gene id: 640132:SROT_RS10055
uniprot id: D6Z940
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

640132:SROT RS10670
gene id: 640132:SROT_RS10670
uniprot id: D6Z9F5
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS08235
gene id: 640132:SROT_RS08235
uniprot id: D6Z826
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

640132:SROT RS09170
gene id: 640132:SROT_RS09170
uniprot id: D6Z8L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

640132:SROT RS00935
gene id: 640132:SROT_RS00935
uniprot id: D6ZAC7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS13895
gene id: 640132:SROT_RS13895
uniprot id: D6ZD18
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

640132:SROT RS12540
gene id: 640132:SROT_RS12540
uniprot id: D6ZBJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

640132:SROT RS09340
gene id: 640132:SROT_RS09340
uniprot id: D6Z8P7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

640132:SROT RS06845
gene id: 640132:SROT_RS06845
uniprot id: D6Z7A1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

640132:SROT RS06240
gene id: 640132:SROT_RS06240
uniprot id: D6ZFJ4
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS01785
gene id: 640132:SROT_RS01785
uniprot id: D6ZB82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.

640132:SROT RS07890
gene id: 640132:SROT_RS07890
uniprot id: D6Z7V7
names: Function
names: Similarity
names: Subunit
messages: Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
messages: Belongs to the AhpD family.
messages: Homotrimer.

640132:SROT RS04145
gene id: 640132:SROT_RS04145
uniprot id: D6ZE20
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

640132:SROT RS03360
gene id: 640132:SROT_RS03360
uniprot id: D6ZD85
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS06015
gene id: 640132:SROT_RS06015
uniprot id: D6ZFE7
names: Similarity
messages: Belongs to the heat shock protein 90 family.

640132:SROT RS10035
gene id: 640132:SROT_RS10035
uniprot id: D6Z935
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.

640132:SROT RS01435
gene id: 640132:SROT_RS01435
uniprot id: D6ZB10
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS06715
gene id: 640132:SROT_RS06715
uniprot id: D6Z777
names: Similarity
messages: Belongs to the LppX/LprAFG lipoprotein family.

640132:SROT RS00080
gene id: 640132:SROT_RS00080
uniprot id: D6Z9I0
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

640132:SROT RS07245
gene id: 640132:SROT_RS07245
uniprot id: D6Z7I1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

640132:SROT RS04435
gene id: 640132:SROT_RS04435
uniprot id: D6ZE76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

640132:SROT RS09155
gene id: 640132:SROT_RS09155
uniprot id: D6Z8K8
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS11505
gene id: 640132:SROT_RS11505
uniprot id: D6ZAL3
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS12055
gene id: 640132:SROT_RS12055
uniprot id: D6ZAW8
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

640132:SROT RS02810
gene id: 640132:SROT_RS02810
uniprot id: D6ZCJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

640132:SROT RS06840
gene id: 640132:SROT_RS06840
uniprot id: D6Z7A0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

640132:SROT RS07770
gene id: 640132:SROT_RS07770
uniprot id: D6Z7T3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS13935
gene id: 640132:SROT_RS13935
uniprot id: D6ZD26
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

640132:SROT RS04385
gene id: 640132:SROT_RS04385
uniprot id: D6ZE66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpC family.
messages: Cell inner membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

640132:SROT RS10390
gene id: 640132:SROT_RS10390
uniprot id: D6Z9A4
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Could possibly oxidize fatty acids using specific components.

640132:SROT RS02640
gene id: 640132:SROT_RS02640
uniprot id: D6ZCG6
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS12800
gene id: 640132:SROT_RS12800
uniprot id: D6ZBP4
names: Function
names: Similarity
messages: Belongs to the catalase family.
messages: Has an organic peroxide-dependent peroxidase activity.

640132:SROT RS10460
gene id: 640132:SROT_RS10460
uniprot id: D6Z9B7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

640132:SROT RS07210
gene id: 640132:SROT_RS07210
uniprot id: D6Z7H3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

640132:SROT RS15340
gene id: 640132:SROT_RS15340
uniprot id: D6ZEL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
messages: Homotetramer.

640132:SROT RS06805
gene id: 640132:SROT_RS06805
uniprot id: D6Z793
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

640132:SROT RS14030
gene id: 640132:SROT_RS14030
uniprot id: D6ZD44
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

640132:SROT RS03725
gene id: 640132:SROT_RS03725
uniprot id: D6ZDF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CbxX/CfxQ family.
messages: Cytoplasm

640132:SROT RS03835
gene id: 640132:SROT_RS03835
uniprot id: D6ZDH3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

640132:SROT RS09025
gene id: 640132:SROT_RS09025
uniprot id: D6Z8I6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.
messages: Cell membrane
messages: Contains a di-nuclear catalytic Mg(2+) center.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

640132:SROT RS00815
gene id: 640132:SROT_RS00815
uniprot id: D6ZAA3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

640132:SROT RS06940
gene id: 640132:SROT_RS06940
uniprot id: D6Z7C0
names: Similarity
messages: Belongs to the truncated hemoglobin family. Group II subfamily.

640132:SROT RS12415
gene id: 640132:SROT_RS12415
uniprot id: D6ZBH0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm

640132:SROT RS13640
gene id: 640132:SROT_RS13640
uniprot id: D6ZCX2
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

640132:SROT RS01805
gene id: 640132:SROT_RS01805
uniprot id: D6ZB87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

640132:SROT RS15370
gene id: 640132:SROT_RS15370
uniprot id: D6ZEM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

640132:SROT RS09605
gene id: 640132:SROT_RS09605
uniprot id: D6Z8V0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

640132:SROT RS13045
gene id: 640132:SROT_RS13045
uniprot id: D6ZC73
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS10365
gene id: 640132:SROT_RS10365
uniprot id: D6Z999
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS08230
gene id: 640132:SROT_RS08230
uniprot id: D6Z825
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

640132:SROT RS08255
gene id: 640132:SROT_RS08255
uniprot id: D6Z830
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

640132:SROT RS12545
gene id: 640132:SROT_RS12545
uniprot id: D6ZBJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

640132:SROT RS03465
gene id: 640132:SROT_RS03465
uniprot id: D6ZDA5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

640132:SROT RS08485
gene id: 640132:SROT_RS08485
uniprot id: D6Z876
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

640132:SROT RS08970
gene id: 640132:SROT_RS08970
uniprot id: D6Z8H5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

640132:SROT RS06230
gene id: 640132:SROT_RS06230
uniprot id: D6ZFJ2
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS11235
gene id: 640132:SROT_RS11235
uniprot id: D6ZA25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Belongs to the precorrin methyltransferase family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

640132:SROT RS10120
gene id: 640132:SROT_RS10120
uniprot id: D6Z953
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

640132:SROT RS12645
gene id: 640132:SROT_RS12645
uniprot id: D6ZBL3
names: Similarity
messages: Belongs to the MmpS family.

640132:SROT RS02250
gene id: 640132:SROT_RS02250
uniprot id: D6ZBV9
names: Similarity
messages: Belongs to the GARS family.

640132:SROT RS03795
gene id: 640132:SROT_RS03795
uniprot id: D6ZDG6
names: Similarity
messages: Belongs to the EccE family.

640132:SROT RS07025
gene id: 640132:SROT_RS07025
uniprot id: D6Z7D7
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

640132:SROT RS08450
gene id: 640132:SROT_RS08450
uniprot id: D6Z869
names: Similarity
messages: Belongs to the CFA/CMAS family.

640132:SROT RS02760
gene id: 640132:SROT_RS02760
uniprot id: D6ZCI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

640132:SROT RS05425
gene id: 640132:SROT_RS05425
uniprot id: D6ZF31
names: Similarity
messages: Belongs to the FBPase class 2 family.

640132:SROT RS06995
gene id: 640132:SROT_RS06995
uniprot id: D6Z7D1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

640132:SROT RS12930
gene id: 640132:SROT_RS12930
uniprot id: D6ZC51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane
messages: Membrane

640132:SROT RS07520
gene id: 640132:SROT_RS07520
uniprot id: D6Z7N5
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

640132:SROT RS08025
gene id: 640132:SROT_RS08025
uniprot id: D6Z7Y4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.
messages: The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

640132:SROT RS11120
gene id: 640132:SROT_RS11120
uniprot id: D6ZA02
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS06265
gene id: 640132:SROT_RS06265
uniprot id: D6ZFJ9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

640132:SROT RS14385
gene id: 640132:SROT_RS14385
uniprot id: D6ZDP2
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

640132:SROT RS08845
gene id: 640132:SROT_RS08845
uniprot id: D6Z8F0
names: Function
messages: Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.

640132:SROT RS03365
gene id: 640132:SROT_RS03365
uniprot id: D6ZD86
names: Function
names: Similarity
messages: Belongs to the UPF0677 family.
messages: Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.

640132:SROT RS14285
gene id: 640132:SROT_RS14285
uniprot id: D6ZDM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

640132:SROT RS05300
gene id: 640132:SROT_RS05300
uniprot id: D6ZF06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with subunits I, II and III to form cytochrome c oxidase.
messages: Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
messages: Cell membrane
messages: Membrane
messages: Part of cytochrome c oxidase, its function is unknown.

640132:SROT RS11520
gene id: 640132:SROT_RS11520
uniprot id: D6ZAL7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

640132:SROT RS15500
gene id: 640132:SROT_RS15500
uniprot id: D6ZDI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

640132:SROT RS13820
gene id: 640132:SROT_RS13820
uniprot id: D6ZD04
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

640132:SROT RS03815
gene id: 640132:SROT_RS03815
uniprot id: D6ZDG9
names: Similarity
messages: Belongs to the AHA1 family.

640132:SROT RS06980
gene id: 640132:SROT_RS06980
uniprot id: D6Z7C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

640132:SROT RS11635
gene id: 640132:SROT_RS11635
uniprot id: D6ZAP0
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

640132:SROT RS12530
gene id: 640132:SROT_RS12530
uniprot id: D6ZBJ0
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

640132:SROT RS11015
gene id: 640132:SROT_RS11015
uniprot id: D6Z9Y1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

640132:SROT RS03530
gene id: 640132:SROT_RS03530
uniprot id: D6ZDB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell inner membrane
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

640132:SROT RS13730
gene id: 640132:SROT_RS13730
uniprot id: D6ZCY6
names: Similarity
messages: Belongs to the F420H(2)-dependent quinone reductase family.

640132:SROT RS13300
gene id: 640132:SROT_RS13300
uniprot id: D6ZCC2
names: Similarity
messages: Belongs to the cytochrome P450 family.

640132:SROT RS10485
gene id: 640132:SROT_RS10485
uniprot id: D6Z9C2
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

640132:SROT RS02190
gene id: 640132:SROT_RS02190
uniprot id: D6ZBU7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

640132:SROT RS07760
gene id: 640132:SROT_RS07760
uniprot id: D6Z7T1
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

640132:SROT RS10175
gene id: 640132:SROT_RS10175
uniprot id: D6Z964
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.
messages: Membrane

640132:SROT RS01860
gene id: 640132:SROT_RS01860
uniprot id: D6ZB98
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS09400
gene id: 640132:SROT_RS09400
uniprot id: D6Z8Q9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

640132:SROT RS12420
gene id: 640132:SROT_RS12420
uniprot id: D6ZBH1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20 family.
messages: Binds 2 Zn(2+) ions per subunit.

640132:SROT RS12835
gene id: 640132:SROT_RS12835
uniprot id: D6ZC34
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

640132:SROT RS09385
gene id: 640132:SROT_RS09385
uniprot id: D6Z8Q7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

640132:SROT RS02020
gene id: 640132:SROT_RS02020
uniprot id: D6ZBR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

640132:SROT RS09680
gene id: 640132:SROT_RS09680
uniprot id: D6Z8W5
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.

640132:SROT RS15055
gene id: 640132:SROT_RS15055
uniprot id: D6ZEF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

640132:SROT RS14295
gene id: 640132:SROT_RS14295
uniprot id: D6ZDM4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane
messages: Membrane

640132:SROT RS03560
gene id: 640132:SROT_RS03560
uniprot id: D6ZDC2
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

640132:SROT RS11355
gene id: 640132:SROT_RS11355
uniprot id: D6ZA49
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

640132:SROT RS01270
gene id: 640132:SROT_RS01270
uniprot id: D6ZAJ5
names: Cofactor
names: Similarity
messages: Belongs to the fatty acid desaturase type 2 family.
messages: Binds 2 iron ions per subunit.

640132:SROT RS00825
gene id: 640132:SROT_RS00825
uniprot id: D6ZAA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

640132:SROT RS10475
gene id: 640132:SROT_RS10475
uniprot id: D6Z9C0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

640132:SROT RS13725
gene id: 640132:SROT_RS13725
uniprot id: D6ZCY5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

640132:SROT RS11145
gene id: 640132:SROT_RS11145
uniprot id: D6ZA07
names: Similarity
messages: Belongs to the barstar family.

640132:SROT RS12970
gene id: 640132:SROT_RS12970
uniprot id: D6ZC59
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS05330
gene id: 640132:SROT_RS05330
uniprot id: D6ZF12
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS09415
gene id: 640132:SROT_RS09415
uniprot id: D6Z8R2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.
messages: Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS17135
gene id: 640132:SROT_RS17135
uniprot id: D6Z9V7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

640132:SROT RS06290
gene id: 640132:SROT_RS06290
uniprot id: D6ZFK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

640132:SROT RS06710
gene id: 640132:SROT_RS06710
uniprot id: D6Z776
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS00280
gene id: 640132:SROT_RS00280
uniprot id: D6Z9M0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

640132:SROT RS01530
gene id: 640132:SROT_RS01530
uniprot id: D6ZB30
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

640132:SROT RS02820
gene id: 640132:SROT_RS02820
uniprot id: D6ZCJ9
names: Similarity
messages: Belongs to the Nudix hydrolase family.

640132:SROT RS13720
gene id: 640132:SROT_RS13720
uniprot id: D6ZCY4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Acyl carrier protein involved in meromycolate extension.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

640132:SROT RS03945
gene id: 640132:SROT_RS03945
uniprot id: D6ZDJ5
names: Similarity
messages: Belongs to the CdaR family.

640132:SROT RS07775
gene id: 640132:SROT_RS07775
uniprot id: D6Z7T4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

640132:SROT RS07060
gene id: 640132:SROT_RS07060
uniprot id: D6Z7E4
names: Similarity
messages: Belongs to the asparaginase 1 family.

640132:SROT RS02655
gene id: 640132:SROT_RS02655
uniprot id: D6ZCG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Cytoplasm

640132:SROT RS08760
gene id: 640132:SROT_RS08760
uniprot id: D6Z8D3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

640132:SROT RS12935
gene id: 640132:SROT_RS12935
uniprot id: D6ZC52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

640132:SROT RS09890
gene id: 640132:SROT_RS09890
uniprot id: D6Z906
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

640132:SROT RS08285
gene id: 640132:SROT_RS08285
uniprot id: D6Z836
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

640132:SROT RS14610
gene id: 640132:SROT_RS14610
uniprot id: D6ZDT5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20 family.
messages: Binds 2 Zn(2+) ions per subunit.

640132:SROT RS08090
gene id: 640132:SROT_RS08090
uniprot id: D6Z7Z7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

640132:SROT RS06770
gene id: 640132:SROT_RS06770
uniprot id: D6Z787
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS11070
gene id: 640132:SROT_RS11070
uniprot id: D6Z9Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpqB lipoprotein family.
messages: Cell membrane

640132:SROT RS15695
gene id: 640132:SROT_RS15695
uniprot id: D6Z9C9
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

640132:SROT RS14910
gene id: 640132:SROT_RS14910
uniprot id: D6ZEC5
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

640132:SROT RS04770
gene id: 640132:SROT_RS04770
uniprot id: D6ZEP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

640132:SROT RS03720
gene id: 640132:SROT_RS03720
uniprot id: D6ZDF1
names: Similarity
messages: Belongs to the CFA/CMAS family.

640132:SROT RS06285
gene id: 640132:SROT_RS06285
uniprot id: D6ZFK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

640132:SROT RS01240
gene id: 640132:SROT_RS01240
uniprot id: D6ZAI9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS09365
gene id: 640132:SROT_RS09365
uniprot id: D6Z8Q3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

640132:SROT RS09125
gene id: 640132:SROT_RS09125
uniprot id: D6Z8K2
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

640132:SROT RS14525
gene id: 640132:SROT_RS14525
uniprot id: D6ZDS2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

640132:SROT RS15495
gene id: 640132:SROT_RS15495
uniprot id: D6ZDB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

640132:SROT RS12150
gene id: 640132:SROT_RS12150
uniprot id: D6ZBC1
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS09985
gene id: 640132:SROT_RS09985
uniprot id: D6Z925
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

640132:SROT RS05120
gene id: 640132:SROT_RS05120
uniprot id: D6ZEW7
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS08220
gene id: 640132:SROT_RS08220
uniprot id: D6Z823
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

640132:SROT RS14430
gene id: 640132:SROT_RS14430
uniprot id: D6ZDQ1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

640132:SROT RS05730
gene id: 640132:SROT_RS05730
uniprot id: D6ZF90
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS11645
gene id: 640132:SROT_RS11645
uniprot id: D6ZAP2
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

640132:SROT RS06485
gene id: 640132:SROT_RS06485
uniprot id: D6ZFP3
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

640132:SROT RS08500
gene id: 640132:SROT_RS08500
uniprot id: D6Z879
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

640132:SROT RS14890
gene id: 640132:SROT_RS14890
uniprot id: D6ZEC1
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS02290
gene id: 640132:SROT_RS02290
uniprot id: D6ZBW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

640132:SROT RS08950
gene id: 640132:SROT_RS08950
uniprot id: D6Z8H1
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

640132:SROT RS07945
gene id: 640132:SROT_RS07945
uniprot id: D6Z7W8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.
messages: Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
messages: Cytoplasm
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS02805
gene id: 640132:SROT_RS02805
uniprot id: D6ZCJ6
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS07930
gene id: 640132:SROT_RS07930
uniprot id: D6Z7W5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

640132:SROT RS09370
gene id: 640132:SROT_RS09370
uniprot id: D6Z8Q4
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

640132:SROT RS01915
gene id: 640132:SROT_RS01915
uniprot id: D6ZBA8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

640132:SROT RS03185
gene id: 640132:SROT_RS03185
uniprot id: D6ZCS2
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

640132:SROT RS13980
gene id: 640132:SROT_RS13980
uniprot id: D6ZD35
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS14625
gene id: 640132:SROT_RS14625
uniprot id: D6ZDT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

640132:SROT RS04205
gene id: 640132:SROT_RS04205
uniprot id: D6ZE32
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MshB deacetylase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.

640132:SROT RS05010
gene id: 640132:SROT_RS05010
uniprot id: D6ZEU5
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.

640132:SROT RS15385
gene id: 640132:SROT_RS15385
uniprot id: D6ZEM3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

640132:SROT RS04225
gene id: 640132:SROT_RS04225
uniprot id: D6ZE36
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

640132:SROT RS10095
gene id: 640132:SROT_RS10095
uniprot id: D6Z948
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

640132:SROT RS05405
gene id: 640132:SROT_RS05405
uniprot id: D6ZF27
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

640132:SROT RS09225
gene id: 640132:SROT_RS09225
uniprot id: D6Z8M3
names: Function
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

640132:SROT RS12715
gene id: 640132:SROT_RS12715
uniprot id: D6ZBM7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

640132:SROT RS04220
gene id: 640132:SROT_RS04220
uniprot id: D6ZE35
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

640132:SROT RS02605
gene id: 640132:SROT_RS02605
uniprot id: D6ZC24
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DyP-type peroxidase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.
messages: Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact.

640132:SROT RS06490
gene id: 640132:SROT_RS06490
uniprot id: D6ZFP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

640132:SROT RS08055
gene id: 640132:SROT_RS08055
uniprot id: D6Z7Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

640132:SROT RS10960
gene id: 640132:SROT_RS10960
uniprot id: D6Z9X0
names: Similarity
messages: Belongs to the peptidase S11 family.

640132:SROT RS08115
gene id: 640132:SROT_RS08115
uniprot id: D6Z801
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

640132:SROT RS10395
gene id: 640132:SROT_RS10395
uniprot id: D6Z9A5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell inner membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

640132:SROT RS14945
gene id: 640132:SROT_RS14945
uniprot id: D6ZED2
names: Similarity
messages: Belongs to the AccD/PCCB family.

640132:SROT RS08705
gene id: 640132:SROT_RS08705
uniprot id: D6Z8C2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

640132:SROT RS03385
gene id: 640132:SROT_RS03385
uniprot id: D6ZD90
names: Similarity
messages: Belongs to the HIBADH-related family.

640132:SROT RS11345
gene id: 640132:SROT_RS11345
uniprot id: D6ZA47
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

640132:SROT RS09625
gene id: 640132:SROT_RS09625
uniprot id: D6Z8V4
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Could possibly oxidize fatty acids using specific components.

640132:SROT RS08465
gene id: 640132:SROT_RS08465
uniprot id: D6Z872
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS12830
gene id: 640132:SROT_RS12830
uniprot id: D6ZC33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

640132:SROT RS02335
gene id: 640132:SROT_RS02335
uniprot id: D6ZBX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 2 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

640132:SROT RS13970
gene id: 640132:SROT_RS13970
uniprot id: D6ZD33
names: Similarity
messages: Belongs to the MmpS family.

640132:SROT RS08945
gene id: 640132:SROT_RS08945
uniprot id: D6Z8H0
names: Similarity
messages: Belongs to the mycobacterial A85 antigen family.

640132:SROT RS15350
gene id: 640132:SROT_RS15350
uniprot id: D6ZEL6
names: Similarity
messages: Belongs to the ParB family.

640132:SROT RS08600
gene id: 640132:SROT_RS08600
uniprot id: D6Z8A0
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS01830
gene id: 640132:SROT_RS01830
uniprot id: D6ZB92
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS10315
gene id: 640132:SROT_RS10315
uniprot id: D6Z990
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

640132:SROT RS09435
gene id: 640132:SROT_RS09435
uniprot id: D6Z8R6
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

640132:SROT RS09845
gene id: 640132:SROT_RS09845
uniprot id: D6Z8Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A probable RNA-binding protein.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm

640132:SROT RS12925
gene id: 640132:SROT_RS12925
uniprot id: D6ZC50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

640132:SROT RS05665
gene id: 640132:SROT_RS05665
uniprot id: D6ZF78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

640132:SROT RS02555
gene id: 640132:SROT_RS02555
uniprot id: D6ZC14
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

640132:SROT RS02060
gene id: 640132:SROT_RS02060
uniprot id: D6ZBR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

640132:SROT RS02645
gene id: 640132:SROT_RS02645
uniprot id: D6ZCG7
names: Similarity
messages: Belongs to the thioesterase PaaI family.

640132:SROT RS10000
gene id: 640132:SROT_RS10000
uniprot id: D6Z928
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS02110
gene id: 640132:SROT_RS02110
uniprot id: D6ZBT0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

640132:SROT RS14535
gene id: 640132:SROT_RS14535
uniprot id: D6ZDS4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

640132:SROT RS13285
gene id: 640132:SROT_RS13285
uniprot id: D6ZCB9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

640132:SROT RS01220
gene id: 640132:SROT_RS01220
uniprot id: D6ZAI4
names: Similarity
messages: Belongs to the SAICAR synthetase family.

640132:SROT RS10435
gene id: 640132:SROT_RS10435
uniprot id: D6Z9B2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

640132:SROT RS01800
gene id: 640132:SROT_RS01800
uniprot id: D6ZB85
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

640132:SROT RS10100
gene id: 640132:SROT_RS10100
uniprot id: D6Z949
names: Similarity
messages: Belongs to the peptidase S11 family.

640132:SROT RS01275
gene id: 640132:SROT_RS01275
uniprot id: D6ZAX9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.
messages: Decarboxylates branched-chain and aromatic alpha-keto acids to aldehydes.

640132:SROT RS06130
gene id: 640132:SROT_RS06130
uniprot id: D6ZFH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 32 family.
messages: Cytoplasm
messages: Enables the bacterium to metabolize sucrose as a sole carbon source.

640132:SROT RS12385
gene id: 640132:SROT_RS12385
uniprot id: D6ZBG4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

640132:SROT RS03775
gene id: 640132:SROT_RS03775
uniprot id: D6ZDG2
names: Similarity
messages: Belongs to the WXG100 family.

640132:SROT RS11500
gene id: 640132:SROT_RS11500
uniprot id: D6ZAL2
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

640132:SROT RS00600
gene id: 640132:SROT_RS00600
uniprot id: D6ZA64
names: Similarity
messages: Belongs to the PhoU family.

640132:SROT RS13355
gene id: 640132:SROT_RS13355
uniprot id: D6ZCD3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine.

640132:SROT RS11605
gene id: 640132:SROT_RS11605
uniprot id: D6ZAN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

640132:SROT RS08605
gene id: 640132:SROT_RS08605
uniprot id: D6Z8A1
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS03495
gene id: 640132:SROT_RS03495
uniprot id: D6ZDB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

640132:SROT RS14350
gene id: 640132:SROT_RS14350
uniprot id: D6ZDN5
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS12090
gene id: 640132:SROT_RS12090
uniprot id: D6ZAX5
names: Subcellular Location Annotation
messages: Cytoplasm

640132:SROT RS10790
gene id: 640132:SROT_RS10790
uniprot id: D6Z9T6
names: Similarity
messages: Belongs to the cytochrome b560 family.

640132:SROT RS14225
gene id: 640132:SROT_RS14225
uniprot id: D6ZDK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Membrane

640132:SROT RS04865
gene id: 640132:SROT_RS04865
uniprot id: D6ZER6
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

640132:SROT RS14215
gene id: 640132:SROT_RS14215
uniprot id: D6ZDK7
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS15475
gene id: 640132:SROT_RS15475
uniprot id: D6ZCH8
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS04215
gene id: 640132:SROT_RS04215
uniprot id: D6ZE34
names: Function
names: Similarity
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: In the C-terminal section; belongs to the radical SAM superfamily. CofH family.
messages: In the N-terminal section; belongs to the radical SAM superfamily. CofG family.

640132:SROT RS10355
gene id: 640132:SROT_RS10355
uniprot id: D6Z997
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

640132:SROT RS06095
gene id: 640132:SROT_RS06095
uniprot id: D6ZFG5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

640132:SROT RS11610
gene id: 640132:SROT_RS11610
uniprot id: D6ZAN5
names: Similarity
messages: Belongs to the peptidase M24B family.

640132:SROT RS09380
gene id: 640132:SROT_RS09380
uniprot id: D6Z8Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

640132:SROT RS14900
gene id: 640132:SROT_RS14900
uniprot id: D6ZEC3
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

640132:SROT RS13330
gene id: 640132:SROT_RS13330
uniprot id: D6ZCC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

640132:SROT RS09675
gene id: 640132:SROT_RS09675
uniprot id: D6Z8W4
names: Similarity
messages: Belongs to the 2-oxoadipate dioxygenase/decarboxylase family.

640132:SROT RS08070
gene id: 640132:SROT_RS08070
uniprot id: D6Z7Z3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS09440
gene id: 640132:SROT_RS09440
uniprot id: D6Z8R7
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

640132:SROT RS15670
gene id: 640132:SROT_RS15670
uniprot id: D6Z8E5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell inner membrane
messages: Membrane

640132:SROT RS08440
gene id: 640132:SROT_RS08440
uniprot id: D6Z867
names: Similarity
messages: Belongs to the DEAD box helicase family.

640132:SROT RS04280
gene id: 640132:SROT_RS04280
uniprot id: D6ZE47
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell inner membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

640132:SROT RS02150
gene id: 640132:SROT_RS02150
uniprot id: D6ZBT8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

640132:SROT RS03130
gene id: 640132:SROT_RS03130
uniprot id: D6ZCR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 1 family.
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

640132:SROT RS11480
gene id: 640132:SROT_RS11480
uniprot id: D6ZAK8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS09950
gene id: 640132:SROT_RS09950
uniprot id: D6Z918
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

640132:SROT RS09895
gene id: 640132:SROT_RS09895
uniprot id: D6Z907
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

640132:SROT RS07030
gene id: 640132:SROT_RS07030
uniprot id: D6Z7D8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

640132:SROT RS09580
gene id: 640132:SROT_RS09580
uniprot id: D6Z8U5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ChdC family. Type 2 subfamily.
messages: Fe-coproporphyrin III acts as both substrate and redox cofactor.
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway. The reaction occurs in a stepwise manner with a three-propionate intermediate.

640132:SROT RS07200
gene id: 640132:SROT_RS07200
uniprot id: D6Z7H1
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

640132:SROT RS07875
gene id: 640132:SROT_RS07875
uniprot id: D6Z7V4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS08890
gene id: 640132:SROT_RS08890
uniprot id: D6Z8F9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

640132:SROT RS08405
gene id: 640132:SROT_RS08405
uniprot id: D6Z860
names: Cofactor
names: Domain
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family. Carboxylic acid reductase subfamily.
messages: Binds 1 phosphopantetheine covalently.
messages: Catalyzes the ATP- and NADPH-dependent reduction of carboxylic acids to the corresponding aldehydes.
messages: The N-terminal domain likely catalyzes substrate activation by formation of an initial acyl-AMP intermediate, the central region contains the phosphopantetheine attachment site, and the C-terminal domain catalyzes the reduction by NADPH of the intermediate thioester formed from the attack of the phosphopantetheine thiol at the carbonyl carbon of acyl-AMP.

640132:SROT RS09000
gene id: 640132:SROT_RS09000
uniprot id: D6Z8I1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

640132:SROT RS02945
gene id: 640132:SROT_RS02945
uniprot id: D6ZCM3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

640132:SROT RS14750
gene id: 640132:SROT_RS14750
uniprot id: D6ZDW2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

640132:SROT RS02800
gene id: 640132:SROT_RS02800
uniprot id: D6ZCJ5
names: Similarity
messages: Belongs to the FGGY kinase family.

640132:SROT RS13205
gene id: 640132:SROT_RS13205
uniprot id: D6ZCA3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

640132:SROT RS06185
gene id: 640132:SROT_RS06185
uniprot id: D6ZFI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

640132:SROT RS11830
gene id: 640132:SROT_RS11830
uniprot id: D6ZAS6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mg(2+). Can also accept Mn(2+).

640132:SROT RS04360
gene id: 640132:SROT_RS04360
uniprot id: D6ZE61
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

640132:SROT RS14100
gene id: 640132:SROT_RS14100
uniprot id: D6ZD57
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

640132:SROT RS06205
gene id: 640132:SROT_RS06205
uniprot id: D6ZFI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

640132:SROT RS02965
gene id: 640132:SROT_RS02965
uniprot id: D6ZCM7
names: Function
names: Similarity
messages: Belongs to the UPF0677 family.
messages: Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.

640132:SROT RS02925
gene id: 640132:SROT_RS02925
uniprot id: D6ZCL9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

640132:SROT RS12905
gene id: 640132:SROT_RS12905
uniprot id: D6ZC46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsQ/DivIB family. FtsQ subfamily.
messages: Cell inner membrane
messages: Essential cell division protein.

640132:SROT RS12845
gene id: 640132:SROT_RS12845
uniprot id: D6ZC36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

640132:SROT RS01005
gene id: 640132:SROT_RS01005
uniprot id: D6ZAE1
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

640132:SROT RS00555
gene id: 640132:SROT_RS00555
uniprot id: D6Z9S2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

640132:SROT RS07265
gene id: 640132:SROT_RS07265
uniprot id: D6Z7I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

640132:SROT RS00725
gene id: 640132:SROT_RS00725
uniprot id: D6ZA85
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

640132:SROT RS09215
gene id: 640132:SROT_RS09215
uniprot id: D6Z8M1
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

640132:SROT RS10480
gene id: 640132:SROT_RS10480
uniprot id: D6Z9C1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

640132:SROT RS12360
gene id: 640132:SROT_RS12360
uniprot id: D6ZBF9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

640132:SROT RS03975
gene id: 640132:SROT_RS03975
uniprot id: D6ZDK0
names: Similarity
messages: Belongs to the WXG100 family.

640132:SROT RS11565
gene id: 640132:SROT_RS11565
uniprot id: D6ZAM6
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

640132:SROT RS01850
gene id: 640132:SROT_RS01850
uniprot id: D6ZB96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

640132:SROT RS04700
gene id: 640132:SROT_RS04700
uniprot id: D6ZEN3
names: Similarity
messages: Belongs to the PspA/IM30 family.

640132:SROT RS05695
gene id: 640132:SROT_RS05695
uniprot id: D6ZF84
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

640132:SROT RS03190
gene id: 640132:SROT_RS03190
uniprot id: D6ZCS3
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS01815
gene id: 640132:SROT_RS01815
uniprot id: D6ZB89
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

640132:SROT RS01015
gene id: 640132:SROT_RS01015
uniprot id: D6ZAE3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

640132:SROT RS02025
gene id: 640132:SROT_RS02025
uniprot id: D6ZBR1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

640132:SROT RS04230
gene id: 640132:SROT_RS04230
uniprot id: D6ZE37
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

640132:SROT RS10700
gene id: 640132:SROT_RS10700
uniprot id: D6Z9G0
names: Similarity
messages: Belongs to the AAA ATPase family.

640132:SROT RS08805
gene id: 640132:SROT_RS08805
uniprot id: D6Z8E2
names: Similarity
messages: Belongs to the peptidase S9C family.

640132:SROT RS14460
gene id: 640132:SROT_RS14460
uniprot id: D6ZDQ8
names: Similarity
messages: Belongs to the citrate synthase family.

640132:SROT RS10415
gene id: 640132:SROT_RS10415
uniprot id: D6Z9A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

640132:SROT RS02015
gene id: 640132:SROT_RS02015
uniprot id: D6ZBQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

640132:SROT RS00040
gene id: 640132:SROT_RS00040
uniprot id: D6Z9H2
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

640132:SROT RS13475
gene id: 640132:SROT_RS13475
uniprot id: D6ZCF7
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS08885
gene id: 640132:SROT_RS08885
uniprot id: D6Z8F8
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two nickel ions.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

640132:SROT RS08080
gene id: 640132:SROT_RS08080
uniprot id: D6Z7Z5
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS08700
gene id: 640132:SROT_RS08700
uniprot id: D6Z8C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

640132:SROT RS09695
gene id: 640132:SROT_RS09695
uniprot id: D6Z8W8
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

640132:SROT RS02625
gene id: 640132:SROT_RS02625
uniprot id: D6ZCG3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

640132:SROT RS07575
gene id: 640132:SROT_RS07575
uniprot id: D6Z7P6
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS01650
gene id: 640132:SROT_RS01650
uniprot id: D6ZB54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrgA family.
messages: Cell membrane
messages: Involved in cell division.

640132:SROT RS08895
gene id: 640132:SROT_RS08895
uniprot id: D6Z8G0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

640132:SROT RS01620
gene id: 640132:SROT_RS01620
uniprot id: D6ZB49
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS06300
gene id: 640132:SROT_RS06300
uniprot id: D6ZFK6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

640132:SROT RS08710
gene id: 640132:SROT_RS08710
uniprot id: D6Z8C3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

640132:SROT RS12070
gene id: 640132:SROT_RS12070
uniprot id: D6ZAX1
names: Similarity
messages: Belongs to the AccD/PCCB family.

640132:SROT RS01440
gene id: 640132:SROT_RS01440
uniprot id: D6ZB11
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

640132:SROT RS15200
gene id: 640132:SROT_RS15200
uniprot id: D6ZEI3
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

640132:SROT RS04180
gene id: 640132:SROT_RS04180
uniprot id: D6ZE27
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

640132:SROT RS01955
gene id: 640132:SROT_RS01955
uniprot id: D6ZBP8
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS02395
gene id: 640132:SROT_RS02395
uniprot id: D6ZBY8
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS09355
gene id: 640132:SROT_RS09355
uniprot id: D6Z8Q0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

640132:SROT RS13260
gene id: 640132:SROT_RS13260
uniprot id: D6ZCB4
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

640132:SROT RS04715
gene id: 640132:SROT_RS04715
uniprot id: D6ZEN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

640132:SROT RS14755
gene id: 640132:SROT_RS14755
uniprot id: D6ZDW3
names: Similarity
messages: Belongs to the IMPDH/GMPR family.

640132:SROT RS14980
gene id: 640132:SROT_RS14980
uniprot id: D6ZED9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

640132:SROT RS09515
gene id: 640132:SROT_RS09515
uniprot id: D6Z8T2
names: Subcellular Location Annotation
messages: cell wall

640132:SROT RS11060
gene id: 640132:SROT_RS11060
uniprot id: D6Z9Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

640132:SROT RS06895
gene id: 640132:SROT_RS06895
uniprot id: D6Z7B1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

640132:SROT RS09495
gene id: 640132:SROT_RS09495
uniprot id: D6Z8S8
names: Similarity
messages: Belongs to the LacAB/RpiB family.

640132:SROT RS07580
gene id: 640132:SROT_RS07580
uniprot id: D6Z7P7
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

640132:SROT RS07800
gene id: 640132:SROT_RS07800
uniprot id: D6Z7T8
names: Similarity
messages: Belongs to the UPF0434 family.

640132:SROT RS12595
gene id: 640132:SROT_RS12595
uniprot id: D6ZBK3
names: Similarity
messages: Belongs to the pirin family.

640132:SROT RS02745
gene id: 640132:SROT_RS02745
uniprot id: D6ZCI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

640132:SROT RS00585
gene id: 640132:SROT_RS00585
uniprot id: D6Z9S6
names: Cofactor
names: Similarity
messages: Belongs to the fatty acid desaturase type 2 family.
messages: Binds 2 iron ions per subunit.

640132:SROT RS13860
gene id: 640132:SROT_RS13860
uniprot id: D6ZD11
names: Similarity
messages: Belongs to the AccD/PCCB family.

640132:SROT RS01760
gene id: 640132:SROT_RS01760
uniprot id: D6ZB77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily.
messages: Periplasm

640132:SROT RS08870
gene id: 640132:SROT_RS08870
uniprot id: D6Z8F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

640132:SROT RS09850
gene id: 640132:SROT_RS09850
uniprot id: D6Z8Z8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

640132:SROT RS10775
gene id: 640132:SROT_RS10775
uniprot id: D6Z9T3
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

640132:SROT RS14520
gene id: 640132:SROT_RS14520
uniprot id: D6ZDS0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

640132:SROT RS01090
gene id: 640132:SROT_RS01090
uniprot id: D6ZAF8
names: Similarity
messages: Belongs to the DEAD box helicase family.

640132:SROT RS07690
gene id: 640132:SROT_RS07690
uniprot id: D6Z7R9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

640132:SROT RS00795
gene id: 640132:SROT_RS00795
uniprot id: D6ZA99
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

640132:SROT RS07845
gene id: 640132:SROT_RS07845
uniprot id: D6Z7U7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS12430
gene id: 640132:SROT_RS12430
uniprot id: D6ZBH3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

640132:SROT RS06860
gene id: 640132:SROT_RS06860
uniprot id: D6Z7A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Cell membrane
messages: Membrane

640132:SROT RS03885
gene id: 640132:SROT_RS03885
uniprot id: D6ZDI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. AlkB subfamily.
messages: Cell inner membrane
messages: Membrane

640132:SROT RS03205
gene id: 640132:SROT_RS03205
uniprot id: D6ZCS6
names: Similarity
messages: Belongs to the adenylyl cyclase class-3 family.

640132:SROT RS03525
gene id: 640132:SROT_RS03525
uniprot id: D6ZDB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

640132:SROT RS11510
gene id: 640132:SROT_RS11510
uniprot id: D6ZAL4
names: Subcellular Location Annotation
messages: Cytoplasm

640132:SROT RS12370
gene id: 640132:SROT_RS12370
uniprot id: D6ZBG1
names: Similarity
messages: Belongs to the GcvT family.

640132:SROT RS15035
gene id: 640132:SROT_RS15035
uniprot id: D6ZEF2
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase class-III family.

640132:SROT RS08310
gene id: 640132:SROT_RS08310
uniprot id: D6Z841
names: Similarity
messages: Belongs to the cytochrome P450 family.

640132:SROT RS09510
gene id: 640132:SROT_RS09510
uniprot id: D6Z8T1
names: Similarity
messages: Belongs to the peptidase M1 family.

640132:SROT RS04425
gene id: 640132:SROT_RS04425
uniprot id: D6ZE74
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

640132:SROT RS00110
gene id: 640132:SROT_RS00110
uniprot id: D6Z9I6
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS10885
gene id: 640132:SROT_RS10885
uniprot id: D6Z9V5
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

640132:SROT RS09145
gene id: 640132:SROT_RS09145
uniprot id: D6Z8K6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.
messages: Homodimer.
messages: Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.

640132:SROT RS05620
gene id: 640132:SROT_RS05620
uniprot id: D6ZF69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

640132:SROT RS07785
gene id: 640132:SROT_RS07785
uniprot id: D6Z7T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

640132:SROT RS05065
gene id: 640132:SROT_RS05065
uniprot id: D6ZEV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

640132:SROT RS04930
gene id: 640132:SROT_RS04930
uniprot id: D6ZES9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

640132:SROT RS06295
gene id: 640132:SROT_RS06295
uniprot id: D6ZFK5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

640132:SROT RS01425
gene id: 640132:SROT_RS01425
uniprot id: D6ZB08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

640132:SROT RS07820
gene id: 640132:SROT_RS07820
uniprot id: D6Z7U2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

640132:SROT RS02010
gene id: 640132:SROT_RS02010
uniprot id: D6ZBQ8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

640132:SROT RS12050
gene id: 640132:SROT_RS12050
uniprot id: D6ZAW7
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS02400
gene id: 640132:SROT_RS02400
uniprot id: D6ZBY9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

640132:SROT RS13130
gene id: 640132:SROT_RS13130
uniprot id: D6ZC90
names: Similarity
messages: Belongs to the catalase family.

640132:SROT RS10930
gene id: 640132:SROT_RS10930
uniprot id: D6Z9W4
names: Similarity
messages: Belongs to the class-A beta-lactamase family.

640132:SROT RS15010
gene id: 640132:SROT_RS15010
uniprot id: D6ZEE7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

640132:SROT RS07665
gene id: 640132:SROT_RS07665
uniprot id: D6Z7R4
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

640132:SROT RS14950
gene id: 640132:SROT_RS14950
uniprot id: D6ZED3
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

640132:SROT RS06910
gene id: 640132:SROT_RS06910
uniprot id: D6Z7B4
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

640132:SROT RS00995
gene id: 640132:SROT_RS00995
uniprot id: D6ZAD9
names: Similarity
messages: Belongs to the glutathione peroxidase family.

640132:SROT RS09210
gene id: 640132:SROT_RS09210
uniprot id: D6Z8M0
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for chromosome condensation and partitioning.

640132:SROT RS09165
gene id: 640132:SROT_RS09165
uniprot id: D6Z8L0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

640132:SROT RS11325
gene id: 640132:SROT_RS11325
uniprot id: D6ZA43
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

640132:SROT RS06705
gene id: 640132:SROT_RS06705
uniprot id: D6Z775
names: Similarity
messages: Belongs to the ABC transporter superfamily.

640132:SROT RS00595
gene id: 640132:SROT_RS00595
uniprot id: D6ZA63
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

640132:SROT RS11395
gene id: 640132:SROT_RS11395
uniprot id: D6ZA57
names: Similarity
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Homohexamer. Assembles into a hexameric ring structure.

640132:SROT RS03790
gene id: 640132:SROT_RS03790
uniprot id: D6ZDG5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

640132:SROT RS11385
gene id: 640132:SROT_RS11385
uniprot id: D6ZA55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

640132:SROT RS05125
gene id: 640132:SROT_RS05125
uniprot id: D6ZEW8
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS00590
gene id: 640132:SROT_RS00590
uniprot id: D6ZA62
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

640132:SROT RS15180
gene id: 640132:SROT_RS15180
uniprot id: D6ZEH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

640132:SROT RS07320
gene id: 640132:SROT_RS07320
uniprot id: D6Z7J6
names: Subcellular Location Annotation
messages: Membrane

640132:SROT RS00775
gene id: 640132:SROT_RS00775
uniprot id: D6ZA95
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

640132:SROT RS09455
gene id: 640132:SROT_RS09455
uniprot id: D6Z8S0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

640132:SROT RS00070
gene id: 640132:SROT_RS00070
uniprot id: D6Z9H8
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

640132:SROT RS13830
gene id: 640132:SROT_RS13830
uniprot id: D6ZD06
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

640132:SROT RS05320
gene id: 640132:SROT_RS05320
uniprot id: D6ZF10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

640132:SROT RS03505
gene id: 640132:SROT_RS03505
uniprot id: D6ZDB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

640132:SROT RS12475
gene id: 640132:SROT_RS12475
uniprot id: D6ZBH9
names: Similarity
messages: Belongs to the WXG100 family.

640132:SROT RS12225
gene id: 640132:SROT_RS12225
uniprot id: D6ZBD7
names: Similarity
messages: Belongs to the acyltransferase PapA5 family.

640132:SROT RS08085
gene id: 640132:SROT_RS08085
uniprot id: D6Z7Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

640132:SROT RS02600
gene id: 640132:SROT_RS02600
uniprot id: D6ZC23
names: Similarity
messages: Belongs to the EfeM/EfeO family.

640132:SROT RS09915
gene id: 640132:SROT_RS09915
uniprot id: D6Z911
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

640132:SROT RS11845
gene id: 640132:SROT_RS11845
uniprot id: D6ZAS9
names: Similarity
messages: Belongs to the XFP family.

640132:SROT RS05740
gene id: 640132:SROT_RS05740
uniprot id: D6ZF92
names: Similarity
messages: Belongs to the universal stress protein A family.

640132:SROT RS09115
gene id: 640132:SROT_RS09115
uniprot id: D6Z8K0
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

640132:SROT RS07525
gene id: 640132:SROT_RS07525
uniprot id: D6Z7N6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

640132:SROT RS13415
gene id: 640132:SROT_RS13415
uniprot id: D6ZCE5
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 FMN per subunit.

640132:SROT RS14515
gene id: 640132:SROT_RS14515
uniprot id: D6ZDR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.